[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr7:98,915,958-101,185,166

Best TWAS P=1.68e-14 · Best GWAS P=1.31e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Heart Atrial Appendage	GIGYF1	0.12	0.07	lasso	8	0.05	2.8e-03	7.0	7.7	1.7e-14	0.85	0.02	0.85	TRUE
9	GTEx	Artery Tibial	ACHE	0.10	0.09	lasso	5	0.08	9.2e-07	7.0	7.0	2.2e-12	0.96	0.01	0.99	TRUE
43	GTEx	Whole Blood	GIGYF1	0.04	0.02	lasso	5	0.01	5.5e-02	6.2	6.4	1.3e-10	0.46	0.09	0.44	TRUE
47	YFS	Blood	TRIP6	0.08	0.10	lasso	6	0.11	6.7e-35	7.0	-6.2	4.5e-10	-0.90	0.01	0.99	TRUE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACHE	0.03	0.01	blup	56	0.01	1.8e-03	6.2	6.1	1.2e-09	0.82	0.01	0.72	TRUE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	GIGYF1	0.03	0.02	blup	30	0.02	4.7e-03	6.3	5.9	3.6e-09	0.42	0.00	0.86	TRUE
29	GTEx	Nerve Tibial	ZKSCAN1	0.10	0.04	lasso	6	0.04	5.5e-04	5.1	5.6	1.8e-08	0.11	0.01	0.99	TRUE
13	GTEx	Brain Nucleus accumbens basal ganglia	STAG3	0.25	0.28	lasso	7	0.28	3.8e-08	4.2	5.5	4.0e-08	0.25	0.34	0.58	TRUE
15	GTEx	Brain Putamen basal ganglia	STAG3	0.36	0.03	lasso	12	0.09	3.1e-03	6.2	7.6	2.9e-14	0.33	0.03	0.82	FALSE
31	GTEx	Ovary	GIGYF1	0.23	0.15	lasso	5	0.14	2.9e-04	6.1	7.4	1.3e-13	0.79	0.02	0.89	FALSE
6	GTEx	Artery Aorta	ACHE	0.35	0.31	enet	35	0.32	1.9e-18	7.1	7.3	3.6e-13	0.91	0.01	0.99	FALSE
27	GTEx	Nerve Tibial	ACHE	0.28	0.23	lasso	7	0.22	6.1e-16	7.0	7.2	7.0e-13	0.95	0.01	0.99	FALSE
18	GTEx	Esophagus Mucosa	ACHE	0.08	0.03	lasso	9	0.03	2.2e-03	5.2	7.0	1.9e-12	0.73	0.03	0.91	FALSE
28	GTEx	Nerve Tibial	SRRT	0.13	0.12	lasso	4	0.11	3.7e-08	7.0	7.0	2.0e-12	0.98	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	ACHE	0.04	0.04	lasso	2	0.03	3.0e-04	7.0	7.0	2.1e-12	0.98	0.01	0.98	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	GIGYF1	0.11	0.00	lasso	5	0.00	2.2e-01	5.3	7.0	2.5e-12	0.66	0.04	0.60	FALSE
36	GTEx	Skin Sun Exposed Lower leg	ACHE	0.07	0.10	lasso	1	0.09	3.5e-08	7.0	7.0	3.6e-12	0.94	0.01	0.99	FALSE
20	GTEx	Heart Atrial Appendage	ACHE	0.19	0.19	lasso	2	0.18	2.6e-08	7.0	6.9	4.2e-12	0.93	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UFSP1	0.09	0.03	blup	53	0.05	1.2e-03	4.4	-6.9	5.4e-12	-0.79	0.02	0.57	FALSE
40	GTEx	Thyroid	GIGYF1	0.33	0.24	lasso	7	0.24	1.5e-18	6.3	6.4	1.3e-10	0.47	0.64	0.36	FALSE
39	GTEx	Thyroid	ACHE	0.19	0.10	enet	33	0.14	1.5e-10	7.0	6.4	1.5e-10	0.76	0.01	0.99	FALSE
7	GTEx	Artery Aorta	SRRT	0.11	0.09	enet	20	0.09	1.4e-05	7.0	6.4	1.7e-10	0.74	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	GIGYF1	0.14	0.10	enet	22	0.14	1.9e-11	6.2	6.3	2.4e-10	0.49	0.73	0.27	FALSE
30	GTEx	Nerve Tibial	GIGYF1	0.17	0.14	enet	7	0.14	2.3e-10	6.2	6.3	3.4e-10	0.43	0.68	0.32	FALSE
25	GTEx	Muscle Skeletal	TRIP6	0.08	0.07	lasso	4	0.07	5.3e-07	6.3	6.2	4.2e-10	0.53	0.30	0.68	FALSE
21	GTEx	Heart Atrial Appendage	SRRT	0.14	0.01	enet	10	0.02	4.5e-02	7.0	6.2	5.5e-10	0.90	0.01	0.88	FALSE
3	GTEx	Adipose Visceral Omentum	GIGYF1	0.12	0.07	lasso	3	0.04	5.0e-03	6.3	6.2	6.5e-10	0.43	0.08	0.38	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	GIGYF1	0.05	0.06	lasso	3	0.06	4.7e-07	6.2	6.2	7.0e-10	0.42	0.00	0.99	FALSE
4	GTEx	Adrenal Gland	GIGYF1	0.23	0.14	lasso	1	0.07	1.2e-03	6.2	6.2	7.6e-10	0.42	0.13	0.32	FALSE
8	GTEx	Artery Aorta	GIGYF1	0.14	0.11	enet	9	0.11	1.1e-06	6.2	6.1	9.5e-10	0.47	0.43	0.46	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	EPHB4	0.16	0.11	enet	7	0.07	3.8e-03	7.0	-6.1	9.9e-10	-0.93	0.00	0.91	FALSE
16	GTEx	Cells Transformed fibroblasts	GIGYF1	0.21	0.16	lasso	9	0.19	6.2e-14	6.2	6.1	1.0e-09	0.49	0.69	0.31	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TRIP6	0.05	0.01	blup	350	0.01	1.9e-02	-1.9	6.0	1.6e-09	0.50	0.09	0.45	FALSE
24	GTEx	Lung	GIGYF1	0.25	0.13	lasso	7	0.14	4.0e-11	6.3	6.0	2.2e-09	0.45	0.64	0.36	FALSE
26	GTEx	Muscle Skeletal	GIGYF1	0.10	0.03	enet	14	0.06	6.8e-07	6.2	5.9	3.3e-09	0.55	0.51	0.47	FALSE
42	GTEx	Whole Blood	ACHE	0.08	0.00	enet	11	0.02	9.2e-03	5.1	5.9	3.9e-09	0.43	0.08	0.35	FALSE
32	GTEx	Pituitary	GIGYF1	0.24	0.01	lasso	7	0.03	5.7e-02	5.6	5.8	5.2e-09	0.44	0.10	0.06	FALSE
38	GTEx	Stomach	GIGYF1	0.24	0.03	lasso	5	0.07	4.7e-04	6.3	5.8	6.1e-09	0.33	0.22	0.40	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	SRRT	0.05	0.02	bslmm	331	0.02	1.1e-03	7.0	5.7	9.1e-09	0.81	0.01	0.98	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	TRIP6	0.11	0.02	lasso	6	0.01	1.3e-01	-4.6	5.7	9.9e-09	0.54	0.07	0.31	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	SLC12A9	0.07	0.05	lasso	4	0.07	7.6e-10	-4.0	5.6	1.7e-08	0.63	0.90	0.10	FALSE
10	GTEx	Artery Tibial	ZKSCAN1	0.07	0.03	lasso	6	0.00	1.2e-01	5.7	5.6	2.1e-08	0.10	0.01	0.96	FALSE
33	GTEx	Prostate	GIGYF1	0.51	0.06	lasso	10	0.05	2.0e-02	6.3	5.6	2.2e-08	0.53	0.04	0.44	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	MCM7	0.04	0.04	lasso	6	0.03	2.2e-04	5.7	5.5	3.0e-08	0.04	0.00	0.99	FALSE
5	GTEx	Artery Aorta	TRIP6	0.10	0.05	enet	15	0.04	3.3e-03	-4.7	5.5	4.0e-08	0.56	0.23	0.57	FALSE
37	GTEx	Skin Sun Exposed Lower leg	UFSP1	0.06	0.01	lasso	4	0.02	3.5e-03	-3.5	-5.5	4.1e-08	-0.36	0.28	0.06	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	GIGYF1	0.29	0.09	lasso	3	0.12	5.6e-05	4.5	5.4	5.3e-08	0.44	0.57	0.19	FALSE
19	GTEx	Esophagus Mucosa	GIGYF1	0.10	0.01	enet	15	0.07	1.0e-05	6.2	5.4	7.1e-08	0.45	0.33	0.44	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	ZSCAN21	0.02	0.02	blup	41	0.02	1.3e-03	5.1	-5.4	8.0e-08	-0.10	0.02	0.84	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	CNPY4	0.22	0.13	lasso	9	0.07	6.9e-03	5.1	5.4	8.3e-08	0.14	0.06	0.49	FALSE
41	GTEx	Thyroid	UFSP1	0.06	0.04	lasso	8	0.03	4.3e-03	5.2	-5.3	9.0e-08	-0.49	0.51	0.05	FALSE
11	GTEx	Brain Cerebellar Hemisphere	STAG3	0.21	0.11	lasso	6	0.12	5.7e-04	5.1	5.2	1.7e-07	0.12	0.16	0.44	FALSE
23	GTEx	Lung	FBXO24	0.08	0.01	lasso	4	0.00	2.2e-01	-3.8	-5.2	1.7e-07	-0.17	0.10	0.05	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EPHB4	0.20	0.07	blup	50	0.10	6.9e-05	3.8	-5.2	1.7e-07	-0.79	0.02	0.74	FALSE
12	GTEx	Brain Cerebellar Hemisphere	SLC12A9	0.17	0.07	lasso	5	0.00	4.5e-01	-3.8	5.2	1.8e-07	0.58	0.04	0.64	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	GIGYF1	0.04	0.03	blup	30	0.03	8.4e-04	6.3	5.2	2.2e-07	0.40	0.01	0.85	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GNB2	0.15	0.01	blup	32	0.01	1.0e-01	6.3	5.2	2.3e-07	0.23	0.00	0.47	FALSE