Hub : Genes

MCM7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0340	1.5e-06	0.074	0.040	0.051	0.057	0.066	2.6e-09	1.1e-05	8.1e-07	1.8e-07	1.8e-08
2	GTEx	Nerve Tibial	0.0866	0.0374	3.4e-03	0.007	NA	0.016	NA	0.014	9.5e-02	NA	2.4e-02	NA	3.4e-02
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1170	0.0520	5.3e-03	0.052	NA	0.002	NA	0.049	8.3e-04	NA	2.3e-01	NA	1.1e-03
4	GTEx	Skin Sun Exposed Lower leg	0.1450	0.0440	4.0e-05	0.089	NA	0.062	NA	0.045	7.7e-08	NA	7.1e-06	NA	1.1e-04
5	GTEx	Thyroid	0.2170	0.0530	2.5e-07	0.169	NA	0.145	NA	0.150	5.8e-13	NA	3.4e-11	NA	1.3e-11
6	METSIM	Adipose	0.0914	0.0356	4.6e-05	0.007	0.006	0.028	0.020	0.026	2.6e-02	3.8e-02	4.0e-05	4.6e-04	6.7e-05
7	NTR	Blood	0.0293	0.0123	1.5e-03	0.007	0.008	0.004	0.009	0.010	2.1e-03	1.3e-03	1.2e-02	6.1e-04	2.5e-04
8	ROSMAP	Brain Pre-frontal Cortex	0.0448	0.0212	4.0e-03	0.037	0.013	0.011	0.018	0.026	1.4e-05	6.5e-03	1.3e-02	2.0e-03	2.2e-04
9	TCGA	Breast Invasive Carcinoma	0.0231	0.0145	4.7e-03	0.008	0.012	0.008	NA	0.008	7.8e-03	1.4e-03	6.0e-03	NA	7.8e-03
10	TCGA	Lung Adenocarcinoma	0.0590	0.0338	4.0e-03	0.021	0.007	0.010	NA	0.009	1.4e-03	4.3e-02	2.2e-02	NA	2.8e-02
11	TCGA	Prostate Adenocarcinoma	0.0433	0.0301	8.9e-03	0.005	0.023	0.026	NA	0.014	7.9e-02	1.5e-03	8.9e-04	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	1.8	1.2	-0.5	0.5	-0.9	-1.3	0.1	-0.9	1.2	-0.9	-1.3	0.1
Bipolar Disorder or Schizophrenia	0.5	1.3	3.4	1.4	-0.9	-0.1	-0.8	-1.6	0.6	-1.3	0.9	-1.4	-1.9	0.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.6	0.3	-0.1	-0.2	0.2	-0.4	0.4	0.0	0.2	0.5	0.7	-0.2
Depression (Nagel 2018)	0.6	0.8	4.5	-0.2	0.1	0.8	1.1	0.0	0.9	0.2	1.3	-0.6	-0.4	2.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.3	-0.1	0.7	1.4	0.2	0.1	0.0	0.1	2.1	1.0	0.3	1.4
Neuroticism (Nagel 2018)	0.5	1.1	2.4	-0.6	1.0	1.1	1.3	0.3	0.2	1.1	1.6	1.1	1.5	0.8
Schizophrenia (2018)	0.3	0.7	1.7	0.8	-0.8	-0.5	-0.4	-1.0	1.0	-0.9	0.2	-1.0	-1.3	-0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	-0.5	0.6	-0.7	0.2	0.5	-0.2	0.3	-1.0	1.0	1.2	-0.6
Worry (Nagel 2018)	0.5	1.2	2.9	-1.3	0.9	1.0	1.4	1.0	0.4	1.4	0.0	0.9	1.7	0.5
Alzheimer’s Disease (in mother)	1.2	1.4	7.1	0.1	-0.7	-1.6	-0.7	0.2	-0.4	-0.6	-2.7	-0.4	-0.5	-1.8
Alzheimer’s Disease (in father)	0.9	1.0	2.9	-1.6	0.9	0.9	1.1	1.7	0.0	1.2	-0.8	-0.5	-0.1	0.1
Alzheimer’s Disease (including proxy)	1.4	2.0	12.9	-0.9	0.1	-1.6	-0.1	1.3	-0.2	0.0	-3.6	-0.5	-0.2	-2.0
Crohns Disease (2017)	0.4	0.9	2.5	-0.8	0.6	1.4	0.7	0.7	1.5	0.7	1.6	0.7	0.2	0.8
Irritable Bowel Disease (IBD)	0.3	0.6	1.4	-0.0	-1.2	0.5	0.3	-0.2	0.8	-0.0	0.8	-1.1	-1.2	1.1
Ulcerative Colitis (UC)	0.4	0.8	3.0	0.1	-1.4	-0.1	0.0	-0.4	0.4	-0.2	-0.0	-1.7	-1.6	0.8
Major Depression (MDD)	0.6	0.8	2.2	1.0	-1.5	-0.1	-0.3	-0.9	-0.9	-0.3	0.2	-1.4	-1.1	0.4
Reaction Time	0.2	0.4	1.1	0.7	-0.6	-0.2	0.1	-0.8	-1.1	-0.4	0.4	0.6	1.0	0.7
Verbal and Numeric Reasoning (VNR)	1.4	3.2	7.2	-1.5	2.4	1.8	1.2	1.5	1.5	1.5	2.7	2.4	1.5	1.3
Breast Cancer	2.1	5.0	9.4	-1.8	2.5	2.7	2.4	1.7	1.8	1.8	3.1	2.0	1.7	2.6
Ovarian Cancer	0.7	0.9	1.8	-0.7	0.9	1.0	0.9	0.7	-0.4	1.1	1.0	1.3	1.3	-0.1
Prostate Cancer	1.1	1.5	2.8	-1.4	0.9	0.5	0.6	1.2	1.2	1.6	-0.9	1.3	1.7	-1.6
Age at First Birth	0.5	0.7	3.6	-0.8	-0.3	0.5	0.7	0.8	1.9	0.5	-0.1	-1.0	-0.6	0.1
Bipolar Disorder (2011)	0.8	0.7	2.5	-0.5	0.2	1.3	0.7	0.5	1.0	0.9	1.6	-0.7	-0.8	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	0.2	-1.1	-0.1	0.5	-0.2	-1.0	0.0	0.6	-0.5	-0.1	1.2
Coronary Artery Disease (CAD)	0.9	1.1	3.7	-0.4	0.6	1.4	1.4	0.3	-0.3	0.7	1.9	0.0	0.2	1.9
Crohns Disease (2012)	2.3	3.7	5.6	-2.3	2.2	1.7	1.8	2.4	1.8	2.2	1.0	2.2	2.0	0.9
Mean Putamen Volume	0.6	0.7	2.7	0.8	-0.9	0.2	0.1	-1.0	0.3	-0.2	1.6	0.8	1.0	0.5
Fasting Glucose	0.6	0.7	1.3	1.0	-0.6	-0.8	-0.9	-0.7	-0.9	-1.1	-0.3	-0.7	-0.7	0.8
HbA1C	2.2	2.5	5.1	1.7	-1.3	-2.1	-2.1	-1.6	-1.4	-1.8	-2.3	-0.5	-0.1	-1.1
HDL Cholesterol	1.3	2.1	4.5	1.3	-1.8	-2.1	-1.4	-1.3	-1.8	-1.3	-1.6	-1.3	-0.9	-0.5
LDL Cholesterol	0.3	0.4	1.8	0.1	0.3	0.6	0.5	-0.2	0.7	-0.3	1.1	-0.4	-0.3	1.3
Lupus	1.3	2.0	5.1	-1.8	1.2	1.5	1.8	1.8	1.3	2.3	1.2	0.2	0.5	0.6
Neuroticism (2016)	0.5	0.8	2.1	-0.3	0.2	1.1	0.9	0.8	0.3	1.2	1.4	-0.6	-0.4	1.1
Primary Biliary Cirrhosis	0.9	1.3	3.0	-0.7	1.3	0.4	0.5	0.7	1.7	0.3	0.6	1.5	1.5	1.7
Rheumatoid Arthritis	0.6	0.8	3.6	-0.5	0.0	-0.9	0.2	0.6	0.8	0.0	-1.9	-1.5	-1.1	-0.1
Schizophrenia (2014)	0.2	0.5	1.2	0.8	-0.5	-0.4	-0.4	-1.0	0.7	-0.7	0.4	-0.8	-1.1	-0.3
Triglycerides	0.5	0.8	2.5	-0.3	0.8	1.2	0.5	0.2	0.8	0.6	1.6	1.4	1.0	0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.6	-0.8	0.3	-0.3	1.1	0.7	0.1	0.5	-1.5	0.8	1.6	-0.1
Ulcerative Colitis	0.7	1.0	3.3	0.5	-1.8	-0.6	-0.3	-0.8	-0.5	-0.4	-0.9	-1.7	-1.2	-0.2
Blood Eosinophil Count	0.2	1.8	5.2	1.9	-1.5	-0.7	-2.3	-2.0	-0.6	-1.4	-0.4	-0.1	-0.2	-1.6
Blood Platelet Count	2.4	28.3	118.8	0.7	-6.2	-0.7	-2.7	-0.9	-2.0	-0.0	-3.0	-10.4	-10.9	-4.8
Blood Red Count	7.4	71.1	349.7	-3.4	7.7	2.6	4.1	2.8	-1.2	5.8	4.0	16.6	18.7	-2.2
Blood White Count	0.1	0.6	2.4	0.5	-1.0	-0.2	-0.9	-0.7	-1.6	0.1	0.2	-0.0	-0.0	-1.1
Heel T-Score	1.9	14.9	24.1	-3.6	4.6	3.6	4.2	3.9	4.6	3.5	1.7	4.2	4.9	2.6
BMI	0.7	4.1	9.8	1.8	-2.8	-2.0	-1.1	-1.8	-3.1	-0.8	-0.7	-2.5	-2.2	-1.9
Height	0.2	4.2	19.7	0.2	0.4	1.5	0.7	-0.3	2.4	-1.1	3.5	-0.9	-1.8	4.4
Waist Hip Ratio (WHR)	0.9	4.1	13.5	-1.7	1.8	2.1	1.4	1.8	1.5	1.9	3.7	2.4	1.6	1.4
Systolic Blood Pressure	0.8	4.1	10.3	-1.9	2.1	3.2	1.2	1.8	1.3	2.5	2.9	2.0	1.4	-0.6
Smoking Status	0.4	1.1	2.5	-1.0	0.5	0.8	1.4	1.0	0.8	1.3	1.4	-0.4	-0.0	1.6
Allergy or Eczema	2.1	5.5	17.7	1.7	-1.3	-2.8	-2.7	-1.7	-1.6	-1.3	-3.4	1.5	1.5	-4.2
Cardiovascular Disease	0.9	2.9	18.9	-0.2	0.8	2.3	1.1	0.3	-0.2	1.2	4.3	1.4	0.8	1.1
Hypothyroidism (self reported)	0.4	0.8	2.5	-0.4	0.9	-0.1	-0.1	0.5	-1.1	0.4	-0.8	1.6	1.5	-1.2
Respiratory disease	1.8	4.1	10.5	1.9	-0.0	-1.6	-3.1	-1.8	-1.6	-1.7	-1.1	2.5	1.5	-3.2
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.3	-0.6	0.9	1.1	-0.1	0.7	-1.6	0.8	1.3	1.8	1.3	-0.6
Lung FEV1/FVC ratio	2.1	10.6	51.1	-1.5	-2.7	-0.9	2.5	1.6	0.9	1.1	-3.7	-7.2	-5.5	0.8
Lung FVC	0.6	2.9	12.3	-0.5	0.9	2.1	0.3	0.4	1.6	0.2	3.5	-0.9	-1.9	2.5
Neuroticism	0.1	0.3	1.5	-0.1	0.1	0.4	0.4	-0.1	-0.0	0.6	0.1	0.9	1.2	-0.5
Chronotype (morning person)	0.2	0.4	1.2	0.1	-0.5	-0.4	0.5	-0.1	-1.1	-0.1	-1.0	-0.2	0.8	0.8
Hair Pigment	0.1	4.0	14.3	0.8	-1.6	-1.5	-1.8	-0.7	-3.8	-1.2	-2.2	-2.0	-2.6	-1.7
Tanning	0.2	3.0	10.2	1.1	-1.8	-0.9	-1.0	-1.1	-2.2	-1.3	-0.2	-2.9	-3.2	0.2
Hand grip strength (left)	1.2	3.3	16.7	-0.2	0.2	1.4	1.3	0.2	2.2	-0.5	2.3	-1.3	-1.9	4.1
Number of treatments/medications taken	0.5	1.0	4.5	0.2	0.6	0.3	-0.7	-0.2	-0.0	0.3	0.1	1.7	1.5	-2.1
Average weekly spirits intake	0.7	0.9	2.1	-1.0	1.4	1.4	0.8	0.8	1.2	1.1	0.4	0.5	0.5	-0.4
Sensitivity / hurt feelings	0.5	0.9	1.7	1.2	-0.6	-0.8	-0.9	-1.3	-0.6	-1.1	-0.5	-0.7	-0.9	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.4	-0.0	0.1	0.1	0.8	-0.0	1.0	-0.1	-0.0	-0.5	-0.3	1.2
Hearing difficulty/problems: Yes	0.2	0.2	0.6	0.5	0.2	-0.3	0.3	-0.5	0.1	-0.3	0.7	-0.6	-0.6	0.8
Relative age of first facial hair	0.8	1.7	5.8	0.4	-1.0	1.1	0.7	-0.5	0.1	-0.3	1.2	-2.3	-2.4	1.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	8.0	-1.8	2.2	0.8	1.6	1.7	1.0	1.8	-0.3	2.1	2.8	0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.4	-0.0	-0.9	0.2	-0.1	0.0	-1.0	-0.0	-0.7	-2.1	-1.9	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	1.1	-0.1	0.0	-0.6	-0.2	0.1	0.1	-0.1	-1.0	-0.4	-0.4	-0.8
Systolic blood pressure, automated reading	0.7	2.0	5.0	-1.5	1.6	2.2	0.9	1.5	0.8	1.8	1.7	1.0	0.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.1	-0.8	1.0	0.7	0.6	0.8	0.1	0.9	0.3	-0.0	0.0	0.1
Angina	0.4	0.5	2.2	0.3	0.2	-0.2	-0.4	-0.5	-1.1	0.1	-0.2	0.9	0.9	-1.5
Medication for hormone replacement therapy	1.1	1.3	3.2	-1.4	1.0	1.8	1.5	1.2	0.5	1.5	0.9	-0.2	-0.1	0.8
Vitamin and mineral supplements	0.6	0.8	3.7	-0.1	0.4	0.6	1.1	0.2	0.2	0.3	1.6	0.5	0.5	1.9
Supplements: Zinc	1.4	1.5	3.2	1.7	-1.8	-1.4	-1.3	-1.7	-1.0	-1.5	-0.3	-0.1	-0.2	-0.4
Medication: Co-codamol	0.4	0.4	1.3	0.7	-0.5	-1.1	-0.7	-0.8	-1.1	-0.5	-0.4	-0.3	-0.1	-0.3
Medication: Metformin	0.6	0.8	2.4	0.9	-0.5	-0.5	-1.5	-0.8	-0.7	-0.7	0.1	-0.4	-1.1	-1.5
Diabetes (father)	1.1	1.3	2.0	-1.3	1.3	0.8	1.0	1.3	1.4	1.3	0.6	1.4	1.3	-0.2
Diabetes (mother)	0.5	0.6	2.7	-0.4	1.0	0.4	0.0	0.5	-0.1	0.8	0.1	1.1	0.7	-1.6
Severe depression (siblings)	0.2	0.2	0.7	-0.3	0.3	0.3	0.4	0.2	0.0	0.3	0.4	0.5	0.6	0.9
Pack years adult smoking proportion	0.4	0.7	1.7	1.0	-0.6	0.3	-0.1	-1.1	-0.9	-0.6	1.3	-0.6	-0.6	0.9
Impedance of leg (right)	1.5	7.4	19.3	-1.1	3.4	2.7	1.6	1.0	2.2	1.3	3.5	4.4	4.0	1.9
Leg fat-free mass (left)	1.0	5.2	14.5	1.6	-2.9	-1.9	-1.4	-1.6	-2.0	-1.8	-1.1	-3.8	-3.8	0.1
Trunk fat percentage	0.9	3.7	8.2	2.9	-2.4	-1.8	-1.8	-2.8	-1.9	-2.3	0.5	-1.2	-1.3	-0.5
Hand grip strength (right)	1.3	3.4	17.5	-0.5	0.6	1.5	1.6	0.5	2.5	-0.2	2.5	-0.6	-1.2	4.2
Townsend deprivation index at recruitment	1.1	1.6	6.0	-0.9	0.3	1.1	1.6	0.9	1.0	1.0	1.7	-0.8	-0.6	2.4
Current tobacco smoking	0.7	1.1	2.6	-1.5	1.6	0.5	0.9	1.5	0.4	1.4	-0.0	0.8	0.8	0.5
Average weekly fortified wine intake	0.6	0.7	2.4	-0.7	1.1	0.4	1.0	0.8	0.5	0.6	-0.3	0.9	1.5	0.9
Maternal smoking around birth	0.2	0.3	1.0	-0.2	0.0	0.0	0.8	0.2	-0.2	0.5	1.0	-0.7	-0.5	0.9
Fed-up feelings	0.9	1.7	4.5	0.9	-1.5	-1.6	-0.5	-1.0	-0.6	-0.6	-2.1	-1.9	-1.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.9	0.0	-0.2	0.3	0.5	-0.0	0.5	0.1	0.0	-0.9	-0.7	0.7
Relative age voice broke	2.6	3.9	7.9	2.3	-2.7	-0.9	-1.2	-2.4	-1.7	-2.0	0.3	-2.8	-2.8	0.3
Taking other prescription medications	0.5	0.7	2.8	-0.2	1.5	-0.3	0.1	0.3	-0.4	0.3	-0.2	1.5	1.7	-0.2
Age when periods started (menarche)	2.2	5.3	15.1	2.1	-2.7	0.1	-0.7	-2.1	0.1	-1.6	2.8	-3.6	-3.9	1.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.6	-0.2	-0.6	-0.3	-0.0	0.0	-1.3	0.1	-0.5	-1.6	-1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	4.7	-1.4	2.1	1.3	1.8	1.5	2.2	1.4	1.0	1.4	1.5	0.9
Tinnitus: Yes, but not now, but have in the past	3.2	3.5	8.4	1.7	-1.4	-2.3	-2.1	-1.8	-2.0	-1.3	-2.5	0.1	0.4	-2.9
Qualifications: CSEs or equivalent	0.6	0.8	3.4	0.2	-0.5	-0.6	-0.8	-0.2	-0.1	-0.4	-1.8	-0.3	-0.7	-1.9
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.0	-0.8	0.5	0.0	-0.2	-0.3	0.2	-0.4	-0.7	-0.4	-0.7
High blood pressure	0.9	2.5	18.8	0.0	0.7	2.3	0.6	-0.0	-0.3	0.8	4.3	1.1	0.3	1.0
Hayfever, allergic rhinitis or eczema	2.2	4.7	14.2	1.7	-1.7	-2.7	-2.3	-1.7	-1.7	-1.3	-3.2	0.9	1.0	-3.8
Multivitamins +/- minerals	0.9	1.2	3.2	0.6	-1.0	-1.0	-1.2	-0.8	-0.9	-0.6	-1.5	-1.1	-0.9	-1.8
Stomach or abdominal pain in last month	0.9	1.2	3.7	-0.4	1.3	-0.6	-0.3	0.4	-0.4	0.2	-1.9	1.4	1.9	-1.1
Supplements: Glucosamine	4.5	5.8	9.7	2.6	-2.5	-2.5	-3.1	-2.7	-1.5	-2.7	-2.7	-1.3	-1.4	-2.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-0.9	1.2	0.6	1.1	1.0	-0.5	0.7	-0.4	-0.9	-0.5	0.8
Medication: Atenolol	0.7	0.9	2.1	0.9	-1.0	0.6	-0.6	-0.9	0.6	-0.8	1.4	-1.3	-1.4	0.4
Medication: Levothyroxine sodium	0.5	0.9	1.9	-0.8	1.1	0.1	0.2	0.9	-0.0	1.0	-1.1	1.1	1.2	-1.4
Sitting height	0.1	0.4	1.6	-0.7	0.5	-0.2	0.1	0.7	0.6	-0.3	-1.0	-0.5	-0.6	1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	-0.7	0.9	1.1	0.8	0.8	0.4	0.8	1.3	0.0	-0.2	1.0
High blood pressure (mother)	2.0	2.8	5.1	2.3	-1.6	-1.4	-2.3	-2.2	-0.9	-2.1	-0.8	-0.9	-1.3	-1.5
Body mass index (BMI)	0.9	4.0	9.9	1.6	-2.6	-1.8	-1.1	-1.5	-2.2	-1.1	-0.7	-3.1	-3.1	-1.5
Impedance of leg (left)	1.5	7.3	19.7	-1.2	3.3	2.6	1.5	1.1	2.7	1.4	3.4	4.4	3.9	1.5
Leg predicted mass (left)	1.0	5.3	14.9	1.7	-3.0	-1.9	-1.4	-1.7	-2.0	-1.9	-1.1	-3.8	-3.9	0.1
Trunk fat mass	0.8	3.4	6.0	2.4	-2.3	-1.6	-1.6	-2.4	-1.6	-2.0	0.5	-2.0	-2.2	-0.2
Waist circumference	0.4	1.3	3.7	1.1	-1.5	-1.1	-0.8	-0.9	-1.0	-0.9	0.4	-1.6	-1.9	-0.4
Number of incorrect matches in round	0.3	0.5	1.9	-0.2	0.3	0.3	0.9	0.1	1.3	0.1	0.8	-0.4	0.1	1.4
Past tobacco smoking	1.3	2.3	6.3	1.2	-0.6	-1.8	-1.9	-1.1	-0.8	-1.5	-2.5	0.7	0.3	-2.4
Alcohol usually taken with meals	0.4	0.6	2.2	0.3	-0.0	-0.3	-0.5	-0.3	-0.0	-0.1	-0.3	1.5	1.3	-1.4
Nervous feelings	0.3	0.5	2.3	-0.3	0.4	0.4	0.3	0.1	0.2	0.5	0.4	1.4	1.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	3.1	0.3	-0.4	0.1	0.5	-0.2	0.1	-0.5	-0.3	-0.7	-0.2	1.8
Hearing difficulty/problems with background noise	0.3	0.4	1.3	0.7	0.5	-0.2	-0.4	-0.8	0.3	-0.5	0.7	1.2	1.0	0.2
Hair/balding pattern: Pattern 2	1.0	1.3	3.0	-1.0	1.0	1.7	1.1	0.8	1.2	1.3	1.7	0.4	0.3	0.8
Had menopause	0.6	0.8	4.3	0.1	-0.7	-0.0	-0.0	-0.1	0.4	-0.4	-0.2	-1.8	-2.1	0.0
Had other major operations	1.7	2.1	6.4	0.5	-1.9	-1.3	-1.1	-0.7	-1.3	-0.3	-2.5	-1.3	-0.7	-2.5
Forced vital capacity (FVC)	0.3	1.2	4.9	0.3	-0.0	0.7	-0.5	-0.3	0.5	-0.8	1.4	-1.3	-2.2	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	4.4	-1.2	2.1	1.6	1.6	1.3	2.1	1.3	1.5	1.4	1.3	1.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.7	-1.6	0.4	0.7	1.5	1.6	1.1	1.3	0.4	-1.1	-0.8	1.6
Qualifications: None of the above	0.5	1.0	3.3	0.7	-1.4	-0.5	-0.5	-0.7	-0.7	-0.5	-0.3	-1.8	-1.7	-0.4
Financial difficulties in last 2 years	0.1	0.2	0.5	0.2	0.4	-0.2	-0.4	-0.2	-0.7	-0.2	-0.6	0.4	0.3	-0.4
Mouth/teeth dental problems	3.5	5.3	8.9	2.9	-2.5	-1.4	-2.7	-2.9	-3.0	-2.6	0.1	-1.8	-2.5	-0.9
Heart attack	0.2	0.2	0.7	0.6	-0.3	-0.5	-0.5	-0.6	-0.1	-0.8	-0.4	0.3	0.4	0.5
Allergy	3.3	7.5	18.1	-2.4	1.9	3.4	3.3	2.3	2.4	2.3	3.7	-1.1	-1.0	4.2
Pain all over the body in last month	1.4	1.5	4.0	1.3	-2.0	-0.6	-0.2	-1.3	-0.1	-1.2	-0.1	-2.0	-1.5	1.0
Diabetes (self-reported)	0.7	1.1	2.1	-1.2	1.2	1.4	0.2	1.3	0.4	1.4	1.0	1.1	0.6	-1.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	8.7	0.3	-0.7	-1.9	-1.0	-0.4	-0.2	-0.7	-3.0	-1.0	-0.7	-1.6
Medication: Ramipril	2.6	3.3	6.1	2.2	-2.1	-1.2	-2.5	-2.2	-2.2	-2.1	-0.6	-1.0	-1.4	-1.4
Medication: Simvastatin	1.6	2.3	8.9	-0.9	1.9	2.2	0.7	0.9	0.6	1.4	3.0	1.6	0.9	0.4
Fluid intelligence score	2.4	5.0	7.3	-1.9	2.5	2.3	1.9	1.9	2.5	2.0	2.7	2.7	2.2	1.8
Illnesses of siblings	0.5	0.7	4.3	-0.4	-0.3	-0.9	-0.0	0.3	0.4	0.4	-2.1	-0.4	0.4	-1.1
Neuroticism score	0.1	0.2	0.6	0.5	-0.0	-0.1	0.0	-0.6	0.3	-0.1	-0.1	0.6	0.8	-0.6
Weight	0.7	3.6	10.8	1.7	-2.3	-1.4	-1.1	-1.6	-1.7	-1.6	0.0	-3.0	-3.3	0.1
Impedance of arm (right)	0.8	3.7	16.0	0.8	1.3	0.6	0.1	-0.9	0.1	-0.6	1.9	3.7	4.0	1.9
Arm fat percentage (right)	1.2	4.7	7.6	2.7	-2.8	-2.4	-2.0	-2.6	-2.2	-2.2	-0.6	-2.1	-2.1	-1.2
Trunk fat-free mass	0.4	2.5	13.0	0.4	-1.3	-0.8	-0.6	-0.4	-0.5	-1.0	-0.6	-3.1	-3.6	0.4
Hip circumference	1.1	4.7	8.7	2.3	-2.5	-2.0	-1.7	-2.2	-2.2	-2.3	-1.1	-2.8	-3.0	-0.9
Time employed in main current job	0.2	0.2	0.8	-0.3	0.4	0.7	0.3	0.2	-0.1	0.4	0.4	0.8	0.9	-0.2
Alcohol intake versus 10 years previously	0.1	0.1	0.4	0.2	-0.4	-0.5	-0.1	-0.2	0.5	0.1	0.2	-0.3	-0.1	-0.7
Father’s age at death	3.6	4.8	10.2	1.7	-2.8	-2.7	-1.6	-1.9	-2.1	-1.8	-3.2	-2.2	-1.5	-1.7
Worrier / anxious feelings	0.2	0.4	1.9	0.0	0.4	0.1	0.7	-0.2	0.1	0.2	0.5	0.9	1.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.3	0.2	-0.3	-0.7	-0.3	-0.1	-0.7	-0.3	-1.5	-0.1	0.2	-0.5
Falls in the last year	1.2	1.6	3.2	-1.6	0.4	1.2	1.4	1.7	0.8	1.3	-0.5	-1.8	-1.4	0.9
Hair/balding pattern: Pattern 3	0.8	1.2	3.8	0.8	-0.4	-1.9	-1.0	-0.7	-0.9	-1.2	-1.7	0.2	0.2	-1.5
Number of live births	0.4	0.5	2.6	0.1	0.8	0.3	-0.3	0.0	0.1	-0.1	1.0	1.6	1.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	12.2	-0.4	-0.9	0.4	0.3	0.4	0.6	-0.2	0.0	-3.2	-3.5	1.3
Pulse rate	2.1	3.6	11.0	-0.5	0.2	2.0	2.1	0.3	2.9	1.0	3.3	-1.0	-0.9	3.0
Happiness	0.3	0.4	2.1	0.3	0.2	-0.6	-0.2	-0.4	-0.4	-0.6	-1.4	0.6	1.0	-0.1
Noisy workplace	1.1	1.4	3.9	0.5	-1.2	-1.0	-0.8	-0.6	-1.7	-0.5	-0.9	-1.9	-2.0	-0.9
Qualifications: A levels/AS levels or equivalent	1.4	3.2	4.9	-2.0	2.2	2.0	1.8	2.0	1.5	1.6	1.3	1.7	1.6	1.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.5	-0.2	1.4	-0.9	-0.7	0.3	-0.1	0.1	-1.2	2.9	2.9	-1.9
Mouth/teeth dental problems: Dentures	1.2	2.1	4.8	-2.0	1.2	0.5	1.9	2.2	1.5	2.1	-0.2	0.3	1.2	0.6
Asthma	1.3	2.5	6.5	1.8	-0.3	-0.9	-2.5	-1.6	-1.9	-1.6	-0.8	1.6	0.7	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.5	0.9	-0.2	-1.2	-1.0	-0.8	-1.6	-1.2	-1.0	0.1	-0.2	0.1
Medication: Cholesterol lowering	0.8	1.2	9.3	0.5	-0.3	1.7	0.0	-0.6	-0.0	0.3	3.1	-0.0	-0.4	0.8
Depression (self-reported)	0.5	0.6	2.1	-0.7	-0.0	0.6	1.4	0.7	-0.0	0.9	0.4	-0.9	-0.2	1.4
Medication: Lansoprazole	1.0	1.1	2.4	-1.5	1.5	0.9	0.8	1.5	1.1	1.4	0.2	0.5	0.2	-0.3
Prospective memory result	0.1	0.1	0.5	-0.2	-0.1	0.1	0.3	0.2	-0.7	0.2	-0.1	-0.1	0.0	-0.5
Lung cancer (father)	1.4	1.6	6.7	0.5	-1.6	-0.8	-0.9	-0.5	-0.1	-0.5	-1.2	-2.6	-2.2	-0.7
Illnesses of mother	1.4	1.7	3.4	-1.9	1.5	-0.1	1.3	1.8	0.7	1.4	-0.6	1.3	1.8	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	8.8	-1.3	0.1	1.4	0.9	1.3	1.1	0.7	0.5	-2.6	-3.0	1.7
Pulse wave Arterial Stiffness index	1.8	2.1	3.6	-1.4	1.6	1.8	1.9	1.4	0.2	1.9	1.4	1.2	1.4	0.5
Impedance of arm (left)	0.8	3.9	15.5	1.1	1.3	0.5	-0.3	-1.2	0.1	-1.0	1.8	3.8	3.9	2.0
Arm fat mass (right)	1.0	4.2	8.9	2.1	-2.7	-1.9	-1.6	-2.0	-1.8	-1.8	-0.4	-2.8	-3.0	-1.0
Trunk predicted mass	0.4	2.4	12.4	0.3	-1.3	-0.8	-0.7	-0.3	-0.5	-0.9	-0.7	-3.0	-3.5	0.4
Standing height	0.1	1.4	9.1	0.4	0.4	0.6	-0.2	-0.5	0.8	-1.3	1.6	0.1	-0.5	3.0
Length of working week for main job	1.5	1.6	4.0	-1.4	1.3	1.2	1.2	1.3	2.0	1.2	1.0	0.0	0.1	1.6
Exposure to tobacco smoke at home	0.4	0.4	0.9	-0.8	0.6	0.7	0.3	0.7	0.2	0.6	0.1	-0.9	-1.0	0.3
Breastfed as a baby	0.8	1.0	3.0	0.8	-0.2	-0.7	-1.1	-0.8	-1.7	-0.7	-0.9	0.9	0.8	-1.7
Tense / ‘highly strung’	0.2	0.3	1.9	-0.1	-0.2	0.1	1.0	0.0	0.4	0.1	0.3	-0.7	-0.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	5.4	-1.9	1.5	1.6	2.3	1.9	1.8	1.9	0.8	0.5	0.8	1.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.9	0.3	-0.5	-0.9	-0.0	-0.2	-0.5	-0.1	-1.4	0.1	0.5	-0.8
Birth weight of first child	1.3	2.4	6.1	-1.1	-0.1	1.7	1.9	1.0	1.1	0.7	0.8	-2.3	-2.1	2.5
Peak expiratory flow (PEF)	1.1	2.6	11.7	0.1	-1.6	-0.4	-0.1	0.0	-0.1	-0.5	-1.7	-3.4	-3.2	0.4
Pulse wave reflection index	0.6	0.8	1.5	-0.8	1.0	0.7	0.8	0.9	-0.3	1.0	0.8	1.2	1.2	0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.3	-0.9	0.1	0.1	-0.4	-0.2	-0.1	0.9	-0.6	-0.7	0.8
Loud music exposure frequency	0.2	0.2	0.6	0.2	0.4	0.8	-0.1	-0.3	-0.8	-0.1	0.7	0.4	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	5.5	-1.6	1.6	2.1	1.9	1.6	1.5	1.7	2.4	1.5	1.6	2.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	-0.4	0.7	-0.0	1.0	0.4	1.4	0.2	-0.8	0.4	0.9	0.8
Blood clot in the leg (DVT)	0.8	1.0	2.2	0.5	-1.0	-1.5	-1.2	-0.3	-0.1	-0.9	-1.2	-1.3	-1.3	-0.6
Medication: Paracetamol	0.1	0.2	0.7	-0.0	0.1	-0.5	0.1	0.1	-0.6	0.3	-0.5	0.6	0.8	-0.2
Headache pain in last month	0.3	0.4	1.0	-0.5	0.9	-0.6	0.1	0.5	-0.7	0.3	-0.7	1.0	1.0	-0.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	8.8	-1.6	1.2	-0.7	1.1	1.7	0.9	0.7	-3.0	0.1	0.7	0.3
Glaucoma (self-reported)	0.3	0.4	1.2	-0.5	-0.2	0.5	0.6	0.3	-1.1	0.6	0.4	0.9	0.7	-0.2
Gout (self-reported)	2.0	2.7	6.8	1.4	-2.1	-1.3	-1.3	-1.4	-2.2	-1.1	0.2	-2.1	-2.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.4	-0.4	1.0	0.0	-0.2	0.5	-0.5	0.3	-0.7	1.2	1.0	-0.8
Medication: Amlodipine	0.2	0.3	1.5	-0.3	0.2	1.2	0.4	0.2	-0.1	0.7	1.2	0.0	-0.1	0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.1	1.6	-0.2	-0.4	-1.8	-1.6	-0.7	-1.2	1.2	1.2	0.3	-1.1
Birth weight	1.9	4.0	7.4	2.5	-2.7	-1.2	-0.7	-2.6	-0.9	-2.3	0.7	-2.5	-2.2	2.1
Chronic bronchitis/emphysema (mother)	2.5	3.0	6.3	2.4	-2.3	-1.0	-2.0	-2.5	-2.0	-1.6	1.0	-1.1	-1.0	-0.4
High blood pressure (siblings)	0.7	1.0	5.3	-0.1	0.4	0.6	0.7	0.2	0.5	-0.2	1.8	-0.7	-1.1	2.3
Forced vital capacity (FVC), Best measure	0.4	1.6	3.8	-0.8	0.8	1.7	0.2	0.7	1.0	0.2	1.9	-1.0	-1.9	1.8
Body fat percentage	0.8	3.3	6.9	2.6	-2.3	-1.8	-1.6	-2.5	-1.8	-2.0	0.5	-1.4	-1.6	-0.6
Leg fat percentage (right)	0.3	0.9	1.7	1.3	-0.9	-0.5	-0.5	-1.2	-0.9	-0.6	1.3	-0.9	-1.3	-0.4
Arm fat-free mass (right)	0.5	2.8	14.8	0.3	-1.5	-0.7	-0.4	-0.3	0.1	-0.7	-0.4	-3.4	-3.9	0.4
Exposure to tobacco smoke outside home	0.7	0.9	3.6	0.3	-1.4	-0.3	0.1	-0.3	-0.3	-0.2	0.2	-1.9	-1.3	1.4
Comparative body size at age 10	0.7	2.0	7.8	-1.5	0.7	0.8	2.3	1.6	0.6	1.3	0.6	-0.1	0.7	2.8
Number of full brothers	0.7	0.8	2.4	1.1	-0.3	0.1	-1.5	-1.0	-0.8	-1.0	0.3	0.9	-0.0	-1.4
Worry too long after embarrassment	0.3	0.5	2.4	0.1	0.6	0.6	0.1	-0.3	0.2	0.1	1.6	1.3	0.7	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.5	-0.4	-0.2	1.1	1.0	0.3	0.0	0.7	1.2	-0.8	-0.7	1.2
Wheeze or whistling in the chest in last year	0.3	0.5	2.3	0.5	-0.3	-0.8	-0.4	-0.5	-0.7	-0.2	-1.0	-0.0	-0.1	-1.5
Number of children fathered	0.6	0.7	3.0	0.2	0.1	-0.8	-1.1	-0.2	-1.7	-0.1	-0.8	0.0	-0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	5.1	1.2	0.7	-0.2	-1.4	-1.2	-1.7	-0.9	1.4	2.3	1.5	-0.4
Age at first live birth	0.3	0.5	1.0	-0.8	0.5	0.3	0.4	0.8	0.2	0.7	-0.7	0.9	1.0	-0.8
Pulse wave peak to peak time	1.4	1.6	3.2	1.3	-1.3	-1.5	-1.7	-1.2	0.3	-1.8	-1.1	-1.1	-1.4	-0.2
Health satisfaction	0.2	0.3	1.3	0.2	0.7	0.4	-0.2	-0.3	-0.7	-0.0	-0.1	0.9	1.1	-0.4
Shortness of breath walking on level ground	0.3	0.4	1.4	0.7	-0.7	-0.2	-0.9	-0.8	-0.4	-0.4	-0.0	0.1	-0.2	-1.2
Qualifications: College or University degree	1.7	5.4	9.2	-1.7	3.0	2.7	1.8	1.7	2.2	1.6	2.2	3.0	3.0	2.0
Eye problems/disorders: None of the above	0.9	1.1	2.8	-1.5	1.1	0.8	1.4	1.7	0.9	1.3	-0.2	-0.1	0.0	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.2	-0.3	0.2	0.5	0.3	0.3	1.1	-0.0	0.4	0.1	-0.3	0.9
Emphysema/chronic bronchitis	2.7	3.0	5.9	2.0	-2.4	-0.9	-1.9	-2.1	-2.2	-1.7	0.2	-1.5	-2.0	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	2.3	-0.4	-0.2	1.5	1.0	0.3	1.1	0.3	1.0	-0.7	-0.5	1.5
Neck or shoulder pain in last month	2.3	3.3	10.5	1.9	-1.6	-2.7	-1.6	-1.7	-1.0	-1.9	-3.2	-0.3	0.6	-1.3
Medication: Blood pressure	0.8	1.3	7.1	1.1	-0.9	0.8	-1.0	-1.4	-1.2	-0.2	2.7	0.2	-0.2	-0.6
Angina (self-reported)	0.3	0.4	2.1	0.3	0.2	-0.1	-0.3	-0.4	-1.1	0.2	-0.1	0.7	0.7	-1.5
Migraine (self-reported)	0.4	0.5	2.2	0.1	-0.3	-1.0	-0.3	-0.0	-0.8	-0.3	-1.5	-0.5	-0.6	-1.2
Medication: Ibuprofen	1.6	1.9	3.9	1.5	-0.6	-1.9	-1.6	-1.3	-2.0	-1.8	-1.5	0.0	-0.2	-0.5
Medication: Allopurinol	1.7	2.3	6.5	1.3	-1.8	-1.0	-1.1	-1.3	-1.8	-0.9	0.6	-2.1	-2.5	-0.8
Medication: Omeprazole	0.4	0.5	2.1	-0.2	-0.5	-0.3	0.6	0.3	-1.3	0.7	-0.1	-1.5	-0.7	-0.1
Medication: Seretide 50 evohaler	1.0	1.2	3.8	1.4	-1.3	-0.2	-1.9	-1.6	-0.1	-1.1	-0.1	0.0	-0.6	-1.3
Mean time to correctly identify matches	0.3	0.6	1.7	0.9	-0.1	-0.2	-0.3	-0.9	-0.8	-0.8	0.5	1.2	1.3	0.4
Heart disease (mother)	0.5	0.6	1.2	1.1	0.4	0.5	-0.6	-1.1	-0.5	-1.0	0.7	1.0	0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	0.0	-1.0	-0.2	-0.3	0.0	-1.2	-0.1	-1.0	-1.1	-0.9	-0.7
Whole body fat mass	0.8	3.3	5.9	2.2	-2.3	-1.6	-1.4	-2.1	-1.6	-1.8	0.4	-2.2	-2.4	-0.5
Leg fat mass (right)	0.5	1.9	5.9	1.4	-1.6	-0.9	-0.8	-1.3	-1.2	-0.9	0.8	-2.1	-2.4	-0.5
Arm predicted mass (right)	0.5	2.5	12.7	0.4	-1.6	-0.9	-0.6	-0.4	-0.0	-0.8	-0.5	-3.1	-3.6	0.2
Pulse rate, automated reading	3.5	11.3	39.6	-1.2	0.0	3.7	3.6	1.1	3.8	1.9	6.3	-2.5	-2.7	4.8
Alcohol intake frequency.	0.5	1.3	4.0	-0.4	-1.2	-1.1	-0.1	0.4	0.3	0.7	-1.8	-2.0	-1.1	-1.5
Comparative height size at age 10	0.0	0.1	0.5	-0.4	0.4	-0.2	0.1	0.3	-0.6	-0.2	-0.2	0.1	0.0	0.7
Number of full sisters	0.4	0.5	2.9	0.1	0.0	0.1	0.5	-0.0	-0.3	-0.1	1.7	0.2	0.0	1.6
Suffer from ‘nerves’	0.1	0.2	0.9	-0.2	-0.6	-0.1	0.0	-0.0	0.4	0.1	-0.9	-0.6	-0.2	-0.2
Overall health rating	0.2	0.4	1.6	-0.6	0.9	-0.1	0.2	0.5	-0.4	0.8	-0.9	-0.0	0.3	-1.3
Chest pain or discomfort	0.7	1.0	3.3	0.6	0.1	-0.3	-0.4	-0.7	-0.7	0.1	-0.5	1.7	1.8	-1.8
Had major operations	0.4	0.4	1.2	0.1	0.5	0.1	-0.4	-0.2	-0.9	0.2	-0.8	0.7	1.1	-1.1
Age at last live birth	0.3	0.4	1.4	-0.1	0.2	0.4	-0.3	0.1	0.2	0.3	0.4	1.2	0.9	-1.1
Family relationship satisfaction	1.7	2.1	3.7	-1.6	1.6	1.9	1.6	1.5	1.8	1.4	0.5	0.4	0.7	1.9
Leg pain on walking	2.4	3.0	10.3	0.9	-0.5	-2.0	-2.0	-0.9	-1.6	-0.9	-2.5	1.4	1.1	-3.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.8	0.3	-0.8	-1.6	-0.7	-0.2	-0.9	-0.4	-1.7	-1.1	-1.1	-1.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.7	1.0	-0.1	0.5	0.8	-0.4	0.6	-0.5	0.2	0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.1	0.7	-0.5	0.2	0.1	-0.7	0.9	-0.7	1.5	-0.5	-0.5	1.8
Medication: Aspirin	0.2	0.2	1.4	-0.4	0.2	0.6	-0.1	0.3	0.3	0.6	0.3	0.2	-0.2	-1.2
Supplements: Vitamin C	1.9	2.3	9.6	0.7	-1.0	-1.5	-1.5	-0.7	-0.7	-0.8	-2.6	0.9	0.6	-3.1
Knee pain experienced in last month	1.0	1.5	4.4	0.4	-0.9	-1.5	-0.7	-0.4	-1.3	-0.3	-2.0	-1.3	-0.9	-2.1
Hypertension (Self-reported)	0.8	2.3	17.9	0.2	0.4	2.3	0.5	-0.1	-0.3	0.6	4.2	0.7	-0.1	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.2	-1.3	1.1	-0.4	0.5	1.4	1.1	0.9	-1.5	0.2	0.4	-0.7
Illnesses of father: Heart disease	1.3	1.7	5.1	-0.8	1.6	1.8	1.4	0.8	0.5	0.8	2.2	1.3	0.8	1.4
Illnesses of siblings: Diabetes	0.6	0.8	1.8	-0.5	1.2	0.2	-0.0	0.6	-0.7	0.4	-1.1	1.3	1.2	-1.1
Smoking status: Previous	0.9	1.3	5.3	-0.3	-0.3	1.3	1.4	0.2	0.4	0.8	2.3	-0.8	-0.3	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	5.2	-0.1	-0.1	0.0	-0.0	0.1	0.4	-0.3	0.1	-1.9	-2.3	1.1
Whole body fat-free mass	0.6	3.2	14.1	0.7	-1.9	-1.2	-0.8	-0.7	-0.8	-1.2	-0.7	-3.4	-3.8	0.4
Leg fat-free mass (right)	1.0	5.2	14.5	1.6	-3.0	-2.1	-1.5	-1.6	-1.8	-1.8	-1.4	-3.7	-3.8	-0.2
Arm fat percentage (left)	1.3	5.0	8.2	2.9	-2.8	-2.5	-2.1	-2.7	-2.2	-2.4	-0.6	-2.1	-2.1	-1.2
Average weekly red wine intake	4.1	6.0	10.3	-2.9	2.7	3.2	2.8	2.8	2.7	2.8	2.4	0.8	0.5	1.5
Handedness (chirality/laterality): Left-handed	4.2	5.1	9.1	-2.9	2.3	2.4	3.0	3.0	1.5	2.6	1.8	0.5	0.4	2.4
Mood swings	0.1	0.2	0.6	0.6	-0.8	-0.3	0.2	-0.6	-0.5	-0.2	0.0	-0.5	-0.2	0.0
Loneliness, isolation	0.4	0.5	1.0	-0.5	0.5	-0.3	0.5	0.5	0.9	0.7	-1.0	0.9	0.9	-0.9
Long-standing illness, disability or infirmity	1.4	2.1	7.2	-0.7	2.1	0.6	0.3	0.6	-0.5	0.9	-0.6	2.5	2.7	-1.8
Ever had bowel cancer screening	1.1	1.3	7.0	1.1	-0.8	-0.2	-0.6	-1.1	-2.6	-0.9	0.4	-1.3	-1.1	0.2
Diabetes diagnosed by doctor	1.1	1.7	3.5	-1.6	1.4	1.5	0.6	1.6	-0.1	1.9	1.3	1.4	0.9	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	5.4	2.3	-1.5	-1.4	-1.9	-2.3	-1.8	-2.2	-0.4	-0.8	-0.8	0.0
Friendships satisfaction	0.6	0.8	2.2	-0.4	1.1	0.3	-0.1	0.4	1.0	0.2	-1.1	1.4	1.5	-0.9
Qualifications: nursing, teaching	1.0	1.6	5.2	-1.0	0.9	1.7	1.4	1.0	1.0	0.7	1.5	0.5	0.7	2.3
Commuting to job workplace: Walk	0.7	0.7	1.3	1.1	-1.1	0.2	-0.6	-1.1	0.6	-0.8	1.0	-0.9	-0.8	0.7
Eye problems/disorders: Cataract	2.7	3.1	7.8	2.7	-1.9	-0.9	-2.1	-2.8	-2.1	-2.2	0.8	0.1	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	8.1	-1.5	1.9	1.1	1.6	1.5	1.6	1.5	0.2	2.4	2.8	0.1
Medication for cholesterol	1.7	2.5	7.2	1.3	-1.4	-2.3	-1.3	-1.4	-1.7	-1.7	-2.7	-1.0	-0.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	6.2	1.3	-1.9	-2.5	-1.5	-1.4	-0.5	-1.6	-1.9	-0.8	-0.9	-1.4
Back pain experienced in last month	0.7	1.1	4.3	-0.3	0.6	-1.5	-0.4	0.3	-0.3	0.3	-2.1	0.7	1.0	-1.8
Mineral and other dietary supplements	1.5	2.0	6.6	-0.9	0.8	0.8	2.0	1.1	0.9	1.2	2.3	0.6	0.6	2.6
Breast cancer (self-reported)	7.4	8.8	12.5	2.5	-3.3	-3.5	-3.4	-2.6	-2.9	-3.0	-3.0	-2.7	-3.1	-2.4
Asthma (self-reported)	1.2	2.5	6.6	1.9	-0.4	-1.0	-2.6	-1.7	-1.9	-1.6	-0.6	1.4	0.7	-2.0
Osteoporosis (self-reported)	0.4	0.5	3.9	0.7	-0.2	-0.3	-0.4	-0.8	-2.0	-0.4	0.0	0.3	0.4	-0.5
Osteoarthritis (self-reported)	0.7	0.9	5.0	0.6	-0.3	-1.4	-0.4	-0.6	0.2	-0.7	-2.2	-0.1	0.5	-1.0
Medication: Aspirin	0.2	0.3	1.5	-0.4	0.2	0.4	-0.1	0.3	0.5	0.7	0.1	0.3	0.1	-1.2
Medication: Gliclazide	0.2	0.2	0.9	-0.4	0.4	-0.1	-0.1	0.4	-0.0	0.4	-0.9	0.1	0.2	-1.0
Illnesses of father: None of the above (group 1)	2.9	3.5	8.8	1.2	-2.5	-2.5	-1.8	-1.2	-1.2	-0.9	-3.0	-1.8	-1.1	-2.2
Smoking status: Current	0.6	0.9	2.5	-1.4	1.6	0.2	0.8	1.4	0.4	1.1	-0.4	0.8	0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	6.6	0.9	-1.1	-0.5	-0.5	-0.8	-0.4	-1.3	-0.5	-2.1	-2.6	0.3
Whole body water mass	0.6	3.5	15.3	0.8	-2.0	-1.3	-0.9	-0.8	-0.9	-1.2	-0.8	-3.6	-3.9	0.4
Leg predicted mass (right)	1.0	5.5	14.7	1.7	-3.1	-2.2	-1.6	-1.7	-1.9	-1.9	-1.4	-3.7	-3.8	-0.3
Arm fat mass (left)	1.0	4.3	8.5	2.2	-2.7	-1.9	-1.7	-2.1	-1.8	-1.9	-0.4	-2.7	-2.9	-1.0
Number of self-reported non-cancer illnesses	1.0	1.8	2.4	-1.4	1.6	1.5	1.4	1.4	1.3	1.5	1.0	1.3	1.5	0.7
Average weekly champagne plus white wine intake	0.3	0.4	1.1	0.8	-1.1	-0.5	0.1	-0.8	-0.3	-0.7	0.3	0.1	0.5	1.0
Miserableness	1.2	2.0	3.5	-1.1	1.9	1.6	1.7	1.1	1.8	1.2	1.1	1.3	1.5	1.0
Guilty feelings	2.9	4.4	7.3	-2.1	2.7	1.9	2.6	2.0	2.0	2.2	1.6	1.7	2.1	2.0
Wears glasses or contact lenses	0.5	0.5	1.5	-0.0	1.0	0.9	0.7	0.1	-0.9	0.1	0.4	0.9	1.2	0.5
Ever taken oral contraceptive pill	0.5	0.6	2.0	-0.0	0.5	-0.9	-0.5	0.2	0.4	-0.2	-0.9	1.4	1.2	-0.8
Hearing aid user	0.6	0.7	2.5	-0.0	-0.6	-1.1	-0.3	-0.1	0.0	0.0	-1.5	-0.9	-0.4	-1.6
Mother’s age at death	1.1	1.4	5.1	1.2	-0.5	-1.0	-1.2	-1.2	0.6	-1.8	-2.3	0.2	0.4	-0.9
Financial situation satisfaction	0.5	0.7	1.8	0.4	0.1	-0.2	-1.3	-0.4	-0.6	-0.7	-0.6	-0.7	-1.3	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.0	-0.7	1.3	1.4	0.2	0.6	0.1	0.5	1.4	0.7	0.0	0.2
Commuting to job workplace: Public transport	0.4	0.5	1.9	0.1	-0.3	-0.3	-0.5	-0.2	-0.3	-0.1	-0.6	1.1	1.4	-1.0
Eye problems/disorders: Glaucoma	0.6	0.8	3.0	-0.3	0.1	0.7	0.1	0.1	-0.9	0.5	0.3	1.7	1.2	-1.4
Medication: Blood pressure	1.5	2.9	7.5	-1.1	1.8	2.1	1.0	1.2	1.7	1.3	2.7	2.1	1.6	1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.8	-0.4	0.6	-0.3	0.4	0.2	0.4	0.8	-0.8	1.4	2.0	-1.7
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.1	1.0	-1.1	-0.3	-2.0	-1.1	-0.6	-1.2	-1.7	-1.5	-1.6	-1.8
High cholesterol (Self-reported)	2.7	4.9	10.4	-1.8	2.5	3.0	2.0	1.8	1.8	2.4	3.2	2.0	1.8	0.9
Medication: Bendroflumethiazide	0.9	1.3	3.4	-1.0	1.2	1.8	0.7	0.9	1.1	1.3	1.8	1.1	0.7	-0.0
Medication: Paracetamol	0.3	0.4	1.3	0.3	-0.3	-1.1	-0.4	-0.3	-0.7	-0.1	-1.0	0.3	0.4	-1.1
Medication: Lisinopril	0.4	0.5	3.3	0.6	-0.2	0.9	0.1	-0.6	-1.0	-0.0	1.8	0.0	-0.3	0.1
Medication: Atorvastatin	0.4	0.5	2.4	0.4	0.4	0.7	-0.1	-0.4	0.8	-0.2	1.5	0.3	0.2	0.9
Illnesses of father: High blood pressure	1.4	1.7	4.5	-0.6	0.6	1.9	1.9	0.6	1.3	0.7	2.1	0.0	0.3	2.1
Alcohol drinker status: Never	0.8	0.9	2.9	0.3	0.1	-0.7	-0.9	-0.2	-0.7	-0.3	-1.4	1.1	1.3	-1.7
Ever smoked	1.4	2.5	4.5	-1.9	1.5	1.9	1.9	1.8	0.7	2.1	1.8	-0.1	0.0	1.6
Basal metabolic rate	0.7	3.8	14.9	1.1	-2.2	-1.4	-1.0	-1.1	-1.1	-1.5	-0.6	-3.5	-3.9	0.3
Leg fat percentage (left)	0.3	1.0	1.9	1.3	-1.1	-0.8	-0.7	-1.2	-0.8	-0.6	1.0	-1.0	-1.4	-0.9
Arm fat-free mass (left)	0.5	2.5	13.2	0.3	-1.6	-0.7	-0.3	-0.3	-0.2	-0.6	-0.3	-3.3	-3.6	0.2
Number of operations (self-reported)	0.2	0.3	1.5	-0.4	-0.3	-0.3	0.3	0.2	0.5	0.5	-1.2	-0.6	0.2	-0.6
Average weekly beer plus cider intake	1.6	2.4	5.3	-1.7	2.3	1.3	1.0	1.7	1.7	1.6	1.3	1.8	1.4	0.5
Irritability	0.3	0.5	2.9	0.6	0.0	0.3	0.2	-0.7	-1.0	-0.1	1.7	0.1	0.1	0.7
Risk taking	0.3	0.5	1.2	0.1	-0.3	-1.1	-0.3	-0.1	1.1	-0.7	-1.1	-0.5	-0.5	1.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	0.2	0.6	0.4	0.2	-0.3	0.0	-0.3	0.6	1.0	1.2	0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.3	-0.9	0.4	0.1	0.3	0.9	1.2	0.7	-0.4	-0.9	-0.9	0.0
Age started oral contraceptive pill	0.4	0.4	2.0	0.2	0.6	0.5	-0.1	-0.2	-0.2	-0.2	0.8	1.4	1.2	0.2
Diastolic blood pressure, automated reading	1.9	5.9	30.7	-1.3	1.3	3.3	2.4	1.2	0.9	2.0	5.5	0.6	0.2	2.7
Ever depressed for a whole week	0.2	0.2	2.0	-0.4	0.2	-0.0	0.4	0.3	0.3	0.2	0.0	-0.3	-0.0	1.4
Unable to work because of sickness or disability	0.8	1.1	5.2	0.5	-0.9	-0.8	-0.1	-0.6	-0.9	-0.3	-0.8	-2.3	-1.8	0.1
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.7	-0.3	-0.3	-0.3	-0.8	0.2	-0.7	-0.7	0.2	0.4	0.1
Myopia	1.3	1.9	5.4	-1.0	-0.0	2.0	1.6	0.9	0.1	1.1	1.8	-1.3	-1.0	2.3
Vascular/heart problems diagnosed by doctor	0.6	1.6	12.1	-0.5	-0.2	-1.5	0.0	0.6	0.3	-0.5	-3.5	-1.2	-0.6	0.1
Cholesterol lowering medication	2.9	4.3	8.2	-1.9	2.4	2.4	2.0	2.0	2.2	2.1	2.9	1.1	1.0	2.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-0.9	0.4	-0.0	1.0	1.0	-0.9	1.1	-0.1	-0.9	-0.2	0.1
Pain experienced in last month	0.7	1.1	5.3	-0.6	0.6	1.9	0.5	0.5	0.3	0.4	2.3	-0.1	-0.7	1.2
Supplements: Calcium	0.9	1.0	2.7	0.5	-1.4	-0.6	-0.5	-0.5	-0.9	-0.8	-1.5	-1.6	-1.3	-0.3
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	0.8	-0.4	-0.3	-0.7	-0.8	-1.5	-0.8	0.0	0.1	-0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	0.5	-0.3	-0.4	-0.4	-0.6	0.0	-0.8	-0.2	0.1	0.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.9	0.5	-1.0	-1.7	-1.3	-0.4	-0.1	-1.1	-1.6	-1.3	-1.2	-0.6
Heart disease (siblings)	1.1	1.4	5.8	1.5	-1.2	0.6	-0.5	-1.4	-0.0	-1.1	2.4	-0.3	-0.9	1.0
Alcohol drinker status: Previous	2.5	2.8	5.6	-2.3	1.1	1.3	2.0	2.2	2.3	2.4	1.0	-0.4	-0.1	1.4
Pack years of smoking	0.7	1.0	1.9	1.2	-0.8	0.2	-0.2	-1.3	-1.1	-0.8	1.4	-1.2	-1.2	0.9
Impedance of whole body	1.0	5.1	18.3	0.1	2.2	1.5	0.7	-0.2	1.2	0.1	2.6	4.3	4.2	1.9
Leg fat mass (left)	0.5	2.0	6.2	1.4	-1.8	-1.1	-0.9	-1.3	-1.2	-0.9	0.7	-2.1	-2.5	-0.8
Arm predicted mass (left)	0.5	2.7	13.5	0.4	-1.7	-0.8	-0.4	-0.4	-0.1	-0.7	-0.6	-3.3	-3.7	0.1