TWAS hub - FBXO24

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0781	0.0378	4.5e-03	0.011	NA	-0.003	NA	0.002	4.8e-02	NA	6.3e-01	NA	2.2e-01
2	GTEx	Nerve Tibial	0.1194	0.0557	1.6e-03	0.086	NA	0.055	NA	0.067	1.1e-06	NA	8.7e-05	NA	1.7e-05
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1980	0.0670	3.1e-04	0.043	NA	0.048	NA	0.054	2.2e-03	NA	1.2e-03	NA	6.5e-04
4	TCGA	Lung Adenocarcinoma	0.0281	0.0167	7.7e-03	0.021	0.020	0.011	NA	0.010	1.4e-03	1.9e-03	1.5e-02	NA	2.0e-02
5	TCGA	Prostate Adenocarcinoma	0.1073	0.0397	2.2e-08	0.096	0.093	0.083	NA	0.092	3.1e-10	5.6e-10	4.7e-09	NA	7.6e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Red Count	56.4	544.5	1204.1	-34.7	-24.6	-22.1	19.9	5.4
Blood Platelet Count	7.5	86.8	176.9	13.3	11.2	9.5	-6.3	1.3
Blood clot in the leg (DVT)	7.1	9.1	16.2	4.0	3.5	3.9	0.7	1.0
Deep venous thrombosis (DVT) (self-reported)	6.8	8.8	15.0	3.9	3.5	3.9	0.9	1.0
Supplements: Fish oil (including cod liver oil)	5.5	7.1	12.4	3.5	2.7	2.1	-2.7	-2.2
Cholesterol lowering medication	4.7	6.9	13.1	-1.7	-1.7	-3.6	-2.4	-3.2
Pulse rate	4.6	7.7	20.7	-4.0	-1.0	-4.5	-0.2	1.0
Pulse wave peak to peak time	4.5	5.3	10.6	3.2	3.0	2.5	-0.4	0.4
Diastolic blood pressure, automated reading	4.5	13.8	27.3	-5.2	-3.9	-5.1	-0.1	-0.8
Medication: Ramipril	4.2	5.4	10.6	2.3	3.3	2.9	1.3	1.0
Chronic bronchitis/emphysema (mother)	4.2	4.9	9.0	-2.9	-2.5	-3.0	-0.6	-0.7
Pulse wave Arterial Stiffness index	4.1	4.8	9.7	-3.1	-3.0	-2.4	0.3	-0.3
Schizophrenia (2014)	3.9	8.6	18.9	-3.6	-2.3	-4.3	-1.3	-2.1
Hypothyroidism (self reported)	3.9	8.9	17.1	3.9	1.8	4.1	2.0	2.3
Pulse rate, automated reading	3.9	12.7	40.2	-4.8	-0.1	-6.3	-0.5	0.6
Mineral and other dietary supplements	3.9	5.2	7.0	-2.6	-2.0	-1.5	2.5	2.6
Hypothyroidism/myxoedema (self-reported)	3.5	6.9	13.3	3.5	1.9	3.6	1.6	1.5
Age at First Birth	3.3	4.8	13.1	2.9	1.3	1.0	-3.6	0.0
Rheumatoid Arthritis	3.3	4.5	8.5	2.9	2.6	2.5	0.5	1.1
Medication: Levothyroxine sodium	3.2	5.5	13.2	3.6	2.1	3.0	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	10.5	3.0	2.6	3.2	0.2	2.7
Diabetes diagnosed by doctor	3.2	5.3	8.3	2.4	1.7	2.9	1.8	2.6
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	6.6	-2.6	-2.2	-2.1	-0.1	-1.6
High cholesterol (Self-reported)	3.1	5.6	10.4	-2.0	-2.0	-3.2	-2.2	-2.1
Medication: Metformin	3.0	4.2	7.1	2.6	2.0	2.7	0.7	1.7
Father’s age at death	3.0	4.1	12.5	-0.2	-0.8	-1.0	-2.5	-3.5
Bipolar Disorder or Schizophrenia	2.8	6.9	14.8	-2.9	-1.8	-3.9	-1.6	-2.5
Supplements: Glucosamine	2.8	3.6	6.0	2.5	1.9	1.9	-1.5	-1.6
Schizophrenia (2018)	2.7	5.7	12.0	-2.6	-1.4	-3.5	-1.3	-2.5
Fasting Glucose	2.7	3.3	5.8	2.0	1.9	2.4	1.7	0.0
Respiratory disease	2.7	6.0	8.9	1.7	2.6	2.7	3.0	2.1
Number of incorrect matches in round	2.6	4.4	8.6	-2.1	-2.3	-2.9	-1.1	-1.5
Wheeze or whistling in the chest in last year	2.6	4.7	12.3	-1.5	-0.2	-0.2	3.5	2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	5.2	2.3	2.0	2.2	-0.9	-0.7
Guilty feelings	2.4	3.7	6.0	-2.5	-2.3	-2.2	1.1	1.1
Crohns Disease (2012)	2.3	3.7	7.0	-2.6	-1.4	-1.9	2.1	1.3
Severe depression (siblings)	2.3	2.6	4.2	-2.1	-2.0	-2.1	0.3	-0.4
Diabetes (self-reported)	2.3	3.6	6.2	1.8	1.1	2.3	1.5	2.5
Medication: Seretide 50 evohaler	2.1	2.5	6.4	0.1	1.0	0.9	2.0	2.5
Leg pain on walking	2.1	2.6	4.0	1.7	1.9	2.0	1.6	-0.1
Qualifications: nursing, teaching	2.1	3.2	5.7	1.2	1.3	2.0	2.4	1.8
Type 2 Diabetes (T2D) (2018)	2.0	3.7	6.5	1.3	0.7	2.1	2.6	2.3
Vitamin and mineral supplements	2.0	2.7	5.3	-1.7	-2.3	-2.1	-0.6	-0.7
Diabetes (father)	2.0	2.5	3.3	1.6	1.6	1.8	1.5	1.5
Wears glasses or contact lenses	2.0	2.4	4.5	-1.4	-1.9	-2.1	-0.1	-1.3
Reaction Time	1.9	3.6	6.1	-2.1	-1.2	-2.4	2.5	0.7
Townsend deprivation index at recruitment	1.9	2.7	5.6	-2.4	-1.9	-1.9	0.5	0.5
Eye problems/disorders: Glaucoma	1.9	2.3	4.0	-2.0	-1.8	-1.9	0.4	0.6
Multivitamins +/- minerals	1.8	2.3	4.3	1.8	2.1	2.0	-0.1	0.3
Chronic bronchitis/emphysema (father)	1.8	2.1	5.4	-0.9	-0.1	-0.5	2.3	2.0
Had menopause	1.8	2.2	6.3	0.4	0.2	-1.0	-1.8	-2.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	3.8	1.4	1.9	1.6	1.9	1.5
Glaucoma (self-reported)	1.8	2.1	4.3	-2.1	-1.7	-1.9	0.3	0.3
Mean time to correctly identify matches	1.8	3.5	8.4	-2.0	-1.5	-2.9	1.7	-0.1
Medication for cholesterol	1.8	2.7	4.8	0.9	1.1	2.2	1.7	1.9
Asthma	1.7	3.4	8.0	0.4	1.1	1.6	2.8	2.3
Illnesses of father: None of the above (group 1)	1.7	2.1	4.4	1.2	2.1	1.3	-1.4	-0.9
Risk taking	1.7	2.5	9.4	-0.7	0.3	0.2	3.1	1.6
Lung FEV1/FVC ratio	1.6	8.1	22.6	1.1	0.0	-1.0	-4.8	-4.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.8	-1.1	-0.5	-0.5	2.4	2.2
Heart attack	1.6	2.1	4.5	0.7	0.6	1.6	1.6	2.1
Lung cancer (father)	1.6	1.9	5.7	0.9	1.0	-0.2	-2.4	-1.4
Osteoarthritis (self-reported)	1.6	2.0	3.8	1.9	1.9	1.5	-0.6	-0.5
Medication: Lisinopril	1.6	2.1	5.6	-1.6	-2.4	-1.4	0.5	-0.1
Illnesses of father: High blood pressure	1.6	2.0	3.2	-0.8	-1.6	-1.8	-1.3	-1.3
Relative age voice broke	1.5	2.3	5.3	-0.7	-1.6	-2.3	-1.2	-1.4
High blood pressure (mother)	1.5	2.1	3.1	1.2	1.6	1.6	1.0	1.8
Breastfed as a baby	1.5	1.9	4.0	-1.1	-1.7	-1.0	-0.9	-2.0
Medication: Amlodipine	1.5	2.1	3.9	-1.2	-1.4	-2.0	-1.3	-1.2
High blood pressure (siblings)	1.5	2.2	4.8	1.1	-0.4	-0.8	-2.0	-2.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.1	1.8	1.4	1.4	-1.1	-1.0
Happiness	1.4	1.7	2.5	-1.3	-1.3	-1.6	-0.9	-1.4
Medication: Gliclazide	1.4	1.6	2.3	1.4	1.4	1.5	0.8	1.0
Prostate Cancer	1.3	1.8	5.9	-0.5	-0.3	0.1	1.7	2.4
Nervous feelings	1.3	2.5	8.8	-0.2	-0.2	0.7	1.8	3.0
Pulse wave reflection index	1.3	1.6	4.5	-1.3	-2.1	-1.0	1.0	-0.2
Headache pain in last month	1.3	2.3	3.2	1.7	1.8	1.8	1.0	1.1
Chest pain or discomfort	1.3	1.8	2.7	-1.5	-1.0	-0.8	1.6	1.6
Mood swings	1.3	2.3	4.7	1.5	1.3	1.5	0.7	2.2
Medication: Atorvastatin	1.3	1.6	4.6	-0.3	0.2	-1.0	-2.1	-1.6
Age started oral contraceptive pill	1.3	1.6	3.0	-0.4	-1.2	-1.4	-1.1	-1.7
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	1.0	1.0	1.9	1.2	0.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.5	-0.6	-0.5	-0.5	1.8	2.1
Supplements: Vitamin C	1.2	1.4	2.8	1.2	1.7	1.5	0.8	0.4
Asthma (self-reported)	1.2	2.4	5.1	0.3	1.1	1.3	2.3	2.0
Hearing aid user	1.2	1.4	3.8	0.2	0.8	-0.7	-1.4	-1.9
Alzheimer’s Disease (including proxy)	1.1	1.6	3.1	1.7	1.1	1.8	0.7	-0.5
Breast Cancer	1.1	2.7	5.6	-1.9	-2.4	-1.5	1.4	-0.0
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.2	1.3	1.5	1.5	0.0	0.0
Ulcerative Colitis	1.1	1.6	4.2	-0.8	-0.6	-2.1	-1.3	-1.0
Illnesses of siblings	1.1	1.5	3.1	0.0	1.0	1.5	1.0	1.7
Tense / ‘highly strung’	1.1	1.8	3.3	-1.5	-1.0	-0.9	1.3	1.8
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.9	0.6	0.5	1.4	1.4	1.7
Bipolar Disorder (2018)	1.0	1.6	3.2	-1.3	-1.0	-1.8	-1.1	-0.9
Depression (Nagel 2018)	1.0	1.5	3.3	-1.4	-1.2	-1.8	0.5	0.4
Blood White Count	1.0	7.5	12.2	-3.2	-1.3	-1.9	3.5	3.0
Worrier / anxious feelings	1.0	1.8	4.1	-1.6	-1.6	-2.0	-0.0	-0.2
Loud music exposure frequency	1.0	1.1	2.6	-0.4	-0.2	0.4	1.6	1.6
Shortness of breath walking on level ground	1.0	1.2	2.4	1.0	1.5	1.0	0.7	0.9
Age at last live birth	1.0	1.5	4.0	0.6	0.6	-0.0	-1.6	-2.0
Family relationship satisfaction	1.0	1.2	1.9	-1.4	-1.2	-1.2	0.8	0.7
Mother’s age at death	1.0	1.3	3.4	1.0	1.0	1.9	0.6	0.7
Schizophrenia vs Biploar Disorder	0.9	1.2	4.4	-2.1	-0.8	-1.0	0.0	0.0
Neuroticism (2016)	0.9	1.3	2.4	-1.0	-1.6	-1.6	-0.2	0.7
Triglycerides	0.9	1.5	3.7	-1.9	-1.3	-1.4	0.0	0.0
Maternal smoking around birth	0.9	1.3	2.9	-1.1	-1.4	-0.8	0.2	1.7
Qualifications: CSEs or equivalent	0.9	1.2	2.2	0.7	1.1	0.8	1.1	1.5
Medication: Atenolol	0.9	1.2	4.4	0.5	-0.4	-0.2	-2.1	-1.0
Falls in the last year	0.9	1.2	4.1	1.2	2.0	0.8	-0.1	0.0
Noisy workplace	0.9	1.1	3.1	-0.6	-0.7	-0.9	-1.0	-1.8
Leg fat percentage (right)	0.9	3.3	6.8	-2.2	-0.8	-2.6	-0.3	-2.0
Eye problems/disorders: None of the above	0.9	1.1	1.9	0.5	1.1	1.2	1.4	0.9
Knee pain experienced in last month	0.9	1.4	2.9	1.3	1.1	1.7	0.3	1.2
Smoking status: Previous	0.9	1.4	2.7	1.6	0.6	1.4	-1.2	-0.8
Average weekly red wine intake	0.9	1.3	2.4	-0.0	-1.1	-1.1	-1.5	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.9	-1.7	-1.6	-1.3	0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.7	1.6	2.2	1.3	-0.8	-0.5
Financial situation satisfaction	0.9	1.1	2.7	0.6	0.3	-0.3	-1.6	-1.6
Medication: Blood pressure	0.9	1.6	3.1	-1.0	-1.1	-1.6	-0.5	-1.8
Alcohol drinker status: Never	0.9	1.0	3.6	0.6	0.1	0.4	-1.0	-1.9
Primary Biliary Cirrhosis	0.8	1.1	2.0	1.1	0.7	1.4	0.8	1.2
Cardiovascular Disease	0.8	2.5	5.2	-2.3	-2.0	-1.8	0.4	0.2
Hearing difficulty/problems: Yes	0.8	1.2	2.8	1.7	1.2	1.1	-0.4	0.3
Allergy	0.8	1.9	3.1	-1.2	-1.5	-1.8	-1.6	0.2
Time employed in main current job	0.8	0.9	1.9	-1.2	-0.7	-1.4	0.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.6	1.8	1.7	2.1	0.2	1.5
Worry too long after embarrassment	0.8	1.4	2.7	-1.5	-1.3	-1.7	-0.3	-0.4
Age at first live birth	0.8	1.4	3.0	1.1	0.0	0.6	-1.5	-1.7
Medication: Omeprazole	0.8	1.0	2.4	-0.0	-0.3	0.8	1.3	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	1.4	1.1	0.8	-0.5	-0.9
Ever had bowel cancer screening	0.8	1.0	2.8	0.9	1.1	0.1	0.2	-1.7
Average weekly beer plus cider intake	0.8	1.2	2.9	-1.0	-0.5	0.1	1.3	1.7
Crohns Disease (2017)	0.7	1.5	2.6	-1.6	0.3	-1.2	1.4	1.3
Hand grip strength (right)	0.7	1.8	2.9	-1.7	-0.9	-1.0	1.2	1.6
Forced vital capacity (FVC)	0.7	2.6	4.4	1.1	1.7	1.8	1.2	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.8	-1.1	-1.1	-0.8	1.6	1.7
Pain all over the body in last month	0.7	0.7	1.5	0.3	1.2	0.5	0.4	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	1.3	1.1	1.4	0.3	1.0
Number of full sisters	0.7	0.8	2.0	0.0	-0.2	0.6	1.3	1.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	0.7	1.3	0.6	0.8	1.0
Commuting to job workplace: Walk	0.7	0.8	1.3	0.8	0.9	1.0	0.5	1.1
Breast cancer (self-reported)	0.7	0.9	2.1	0.9	1.4	0.7	-0.3	-0.8
Leg fat percentage (left)	0.7	2.4	4.9	-1.7	-0.2	-2.2	-0.4	-2.0
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-0.7	-0.9	-0.7	-1.1	-1.1
Heart disease (siblings)	0.7	0.8	1.7	-1.1	-1.3	-1.0	0.4	0.3
Ulcerative Colitis (UC)	0.6	1.1	2.8	0.9	1.7	-0.3	-1.1	-0.6
Lupus	0.6	0.9	1.3	0.5	1.1	0.8	0.9	1.1
Blood Eosinophil Count	0.6	4.6	10.9	-3.3	-1.4	-3.2	0.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.8	1.7	0.7	0.2	-0.4	-0.2
Impedance of leg (right)	0.6	2.8	4.8	-2.1	-2.1	-2.2	0.4	0.0
Fed-up feelings	0.6	1.1	2.5	0.5	1.3	0.3	0.9	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.2	-0.7	-0.4	-1.1	0.9	1.1
Age when periods started (menarche)	0.6	1.3	3.6	1.3	0.8	0.3	-1.9	-0.9
Alcohol usually taken with meals	0.6	0.9	1.7	-0.1	0.3	1.2	1.3	1.1
Medication: Simvastatin	0.6	0.9	1.8	0.0	-0.8	-1.3	-1.0	-1.1
Fluid intelligence score	0.6	1.2	2.2	-0.5	-0.6	-1.3	-1.2	-1.5
Hair/balding pattern: Pattern 3	0.6	0.9	2.9	1.1	0.6	1.7	-0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.1	1.5	0.7	1.8	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.0	4.2	1.2	1.2	1.6	0.8	2.1
Comparative height size at age 10	0.6	3.1	6.8	2.0	1.9	2.6	-0.2	1.1
Illnesses of father: Heart disease	0.6	0.9	2.2	-1.1	-1.5	-1.0	0.2	-0.0
Friendships satisfaction	0.6	0.7	2.1	-0.6	-0.2	-1.1	-0.0	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	0.3	0.0	1.1	1.1	1.1
Worry (Nagel 2018)	0.5	1.0	1.5	-1.1	-1.2	-1.0	0.4	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.2	0.0	-0.8	-1.0	-0.7	-1.1
Systolic blood pressure, automated reading	0.5	1.3	3.1	1.8	0.3	1.1	-1.4	-0.5
Current tobacco smoking	0.5	0.8	1.9	-1.2	-0.6	-1.4	0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.2	0.6	0.1	-0.2	-1.1	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	2.1	-0.5	0.3	-0.5	1.5	0.7
Had other major operations	0.5	0.7	2.3	0.6	0.1	0.7	-1.5	-0.5
Alcohol intake versus 10 years previously	0.5	0.7	1.8	1.4	0.9	0.8	-0.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	0.6	0.2	1.1	1.2	0.5
Prospective memory result	0.5	0.6	1.6	0.2	1.1	-0.2	0.1	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.8	1.5	1.0	1.7	-0.2	1.2
Hair/balding pattern: Pattern 4	0.5	1.1	1.9	-1.4	-1.0	-1.2	0.5	-0.9
Medication: Ibuprofen	0.5	0.5	1.8	0.2	0.2	0.9	1.3	0.3
Heart disease (mother)	0.5	0.6	1.6	0.1	-0.2	0.4	1.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	0.5	0.9	0.7	0.0	1.1
Hypertension (Self-reported)	0.5	1.4	2.6	-1.6	-1.5	-1.3	0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	-0.3	0.4	-0.8	-1.3	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	1.0	0.6	0.9	-0.6	-0.5
Number of operations (self-reported)	0.5	0.8	1.4	-0.7	-1.2	-1.1	-0.8	-0.2
Irritability	0.5	0.8	3.0	-0.3	0.1	-0.0	1.0	1.7
Commuting to job workplace: Cycle	0.5	0.6	1.6	1.3	0.6	0.7	0.5	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.6	1.5	1.6	1.3	0.1	-0.6
Supplements: Calcium	0.5	0.6	0.7	0.7	0.7	0.7	0.7	0.8
Alzheimer’s Disease (in father)	0.4	0.5	0.9	1.0	0.4	1.0	0.5	-0.3
Mean Putamen Volume	0.4	0.5	1.2	-1.1	-0.9	-0.2	0.5	0.2
Neuroticism	0.4	1.1	1.5	-1.0	-1.0	-1.1	0.6	1.2
Hair Pigment	0.4	10.4	26.1	5.1	1.9	4.7	0.2	0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.4	1.2	0.8	0.3	0.0	-0.2
Medication: Co-codamol	0.4	0.5	1.3	-0.4	-0.2	-0.6	-0.8	-1.1
Pack years adult smoking proportion	0.4	0.6	1.0	-0.8	-0.6	-0.4	1.0	1.0
Taking other prescription medications	0.4	0.7	2.2	0.6	0.5	0.7	1.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.7	-0.5	-0.5	-0.2	1.6	1.2
High blood pressure	0.4	1.2	2.4	-1.5	-1.6	-1.2	-0.1	0.3
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.3	-0.6	1.0	0.8	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	-0.6	-0.8	-0.6	-0.2	1.2
Neuroticism score	0.4	0.9	3.4	-0.2	-0.1	-0.2	1.0	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.6	-0.2	-0.6	0.1	-0.4	-1.3
Medication: Lansoprazole	0.4	0.4	0.8	-0.4	0.2	-0.9	-0.6	-0.8
Peak expiratory flow (PEF)	0.4	0.9	1.7	1.3	0.7	1.3	-0.7	-0.3
Birth weight	0.4	0.8	1.5	-0.7	-0.9	-1.2	-1.2	0.1
Neck or shoulder pain in last month	0.4	0.6	1.0	1.0	1.0	0.4	-0.4	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	2.0	0.2	0.4	-0.0	1.4	0.6
Leg fat-free mass (right)	0.4	2.2	4.9	1.2	1.8	2.2	0.6	1.1
Loneliness, isolation	0.4	0.5	1.3	-0.5	-0.7	-1.1	0.6	-0.1
Eye problems/disorders: Cataract	0.4	0.5	1.4	-0.7	-0.5	-0.3	0.4	1.2
Smoking status: Current	0.4	0.7	1.6	-1.1	-0.5	-1.3	0.7	-0.2
Leg predicted mass (right)	0.4	2.2	4.9	1.2	1.8	2.2	0.7	1.1
Miserableness	0.4	0.8	2.5	-0.1	-0.1	-0.3	1.1	1.6
Ever taken oral contraceptive pill	0.4	0.4	0.7	0.8	0.4	0.8	0.7	0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.8	0.3	-0.1	-0.3	-1.3	-0.8
Ever smoked	0.4	0.8	2.0	1.4	0.6	1.3	-0.1	0.1
Alcohol drinker status: Previous	0.4	0.4	1.6	0.5	0.0	-0.5	-1.3	-0.3
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	0.7	0.7	0.3	0.6	1.2
Neuroticism (Nagel 2018)	0.3	0.7	1.2	-0.7	-0.9	-0.9	0.2	1.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.6	-0.6	1.1	-1.3	-0.1	0.1
Heel T-Score	0.3	2.4	4.2	-1.4	-1.9	-1.2	2.1	-0.7
Waist Hip Ratio (WHR)	0.3	1.4	3.1	1.1	-0.2	1.8	0.7	1.4
Systolic Blood Pressure	0.3	1.6	3.2	1.6	-0.3	1.8	-0.6	1.4
Smoking Status	0.3	0.7	1.6	-0.6	-0.5	-1.3	-0.5	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.8	0.3	0.3	-0.6	-0.3
Supplements: Zinc	0.3	0.3	0.6	-0.8	-0.6	-0.2	0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-0.3	-0.3	-0.4	-0.4	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.9	-0.5	-0.1	-0.4	0.0	-1.7
Sitting height	0.3	2.4	6.6	1.8	1.4	2.6	-0.1	0.3
Impedance of leg (left)	0.3	1.5	3.7	-1.5	-1.3	-1.9	-0.1	-0.2
Medication: Cholesterol lowering	0.3	0.4	1.8	0.2	-0.3	-0.5	-1.4	0.2
Impedance of arm (left)	0.3	1.2	2.9	-0.9	-1.1	0.2	1.7	1.1
Exposure to tobacco smoke at home	0.3	0.4	0.7	0.6	0.6	0.9	-0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.3	-0.5	-0.5	0.6	1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	0.4	-0.0	-0.6	-0.8	-0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	1.1	0.4	0.5	-0.3	-0.4
Comparative body size at age 10	0.3	0.8	1.3	0.1	-0.4	-1.1	-1.1	-1.1
Emphysema/chronic bronchitis	0.3	0.4	0.9	0.9	0.4	0.8	-0.1	-0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	-0.7	-0.3	-1.3	-0.7	-0.2
Medication: Blood pressure	0.3	0.4	1.7	-0.4	-0.4	0.3	0.1	1.3
Medication: Allopurinol	0.3	0.4	0.8	0.0	-0.3	-0.4	-0.9	-0.9
Suffer from ‘nerves’	0.3	0.5	1.1	-0.7	-0.1	-0.7	0.4	1.1
Overall health rating	0.3	0.6	1.5	0.6	0.5	-0.2	1.0	1.2
Osteoporosis (self-reported)	0.3	0.3	0.8	-0.3	-0.5	-0.9	-0.3	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	-0.3	-0.4	-0.8	0.2	-0.9
Fractured/broken bones in last 5 years	0.3	0.3	0.8	0.5	0.6	-0.0	-0.4	-0.9
Myopia	0.3	0.4	0.8	0.5	0.8	0.6	0.2	0.9
Pain experienced in last month	0.3	0.6	1.2	-1.0	-1.1	-0.6	0.5	-0.1
Impedance of whole body	0.3	1.3	2.3	-1.5	-1.5	-1.1	0.8	0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.8	-0.4	-0.8	0.0	0.0
HbA1C	0.2	0.2	0.4	-0.6	-0.2	-0.5	-0.1	-0.5
HDL Cholesterol	0.2	0.4	1.0	-0.9	-0.3	-1.0	0.0	0.0
BMI	0.2	1.2	3.7	-1.9	-0.2	-1.1	0.8	-0.7
Height	0.2	3.1	7.9	1.9	0.9	2.8	-0.8	1.7
Allergy or Eczema	0.2	0.4	2.1	-0.0	0.3	0.1	0.1	-1.5
Tanning	0.2	1.8	3.8	0.6	1.4	2.0	1.0	1.4
Relative age of first facial hair	0.2	0.4	0.9	0.3	-0.8	-0.6	-1.0	0.0
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.3	-0.6	-0.5	-0.5	0.3
Leg fat-free mass (left)	0.2	1.3	2.9	0.5	1.2	1.7	0.9	1.1
Trunk fat percentage	0.2	0.7	2.2	-0.8	0.5	-0.7	-0.1	-1.5
Leg predicted mass (left)	0.2	1.3	2.9	0.5	1.2	1.7	0.9	1.0
Waist circumference	0.2	0.6	1.3	0.8	1.1	1.0	0.0	-0.6
Past tobacco smoking	0.2	0.4	1.1	-1.0	-0.3	-0.9	0.5	0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.2	0.3	0.6	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.1	-0.6	-0.7	-0.6	-0.0
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.6	-0.4	-0.0	0.8	0.6
Impedance of arm (right)	0.2	1.1	2.0	-0.9	-1.2	0.2	1.4	1.2
Trunk fat-free mass	0.2	1.3	2.5	1.2	1.4	1.6	-0.0	0.8
Number of live births	0.2	0.2	0.5	0.4	0.7	0.0	-0.1	-0.7
Depression (self-reported)	0.2	0.3	0.5	-0.5	-0.6	-0.7	0.1	0.5
Trunk predicted mass	0.2	1.3	2.5	1.2	1.4	1.6	-0.1	0.7
Standing height	0.2	2.1	5.0	1.1	0.8	2.2	0.6	1.7
Length of working week for main job	0.2	0.2	0.3	0.6	0.5	0.2	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.4	-0.5	0.6	0.4	0.7
Medication: Paracetamol	0.2	0.3	0.7	-0.4	0.3	0.4	0.9	0.4
Gout (self-reported)	0.2	0.3	0.9	-0.3	-0.2	-0.4	-0.4	-0.9
Body fat percentage	0.2	0.9	2.3	-1.1	0.4	-1.0	-0.0	-1.5
Number of full brothers	0.2	0.3	0.6	0.8	0.3	0.7	0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.1	-0.4	-0.5	-0.1	1.0
Health satisfaction	0.2	0.2	0.5	0.0	-0.7	-0.6	-0.1	-0.4
Angina (self-reported)	0.2	0.2	0.5	0.4	0.2	0.7	-0.4	0.6
Migraine (self-reported)	0.2	0.2	1.1	-0.0	0.2	-0.1	-0.2	-1.1
Leg fat mass (right)	0.2	0.7	1.2	-1.1	0.3	-1.1	-0.0	-1.0
Alcohol intake frequency.	0.2	0.4	0.8	0.8	0.9	0.3	-0.8	0.2
Had major operations	0.2	0.2	0.5	-0.3	0.2	-0.3	0.7	0.6
Medication: Aspirin	0.2	0.2	0.7	0.8	-0.2	0.6	-0.2	0.0
Whole body fat-free mass	0.2	1.4	2.8	1.0	1.4	1.7	0.3	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.3	0.4	0.4	-0.4	-0.7
Whole body water mass	0.2	1.4	2.8	1.0	1.5	1.7	0.3	0.9
Commuting to job workplace: Public transport	0.2	0.3	1.0	0.1	0.1	0.1	-0.5	-1.0
Medication: Paracetamol	0.2	0.4	1.0	-0.7	0.3	0.3	1.0	0.5
Basal metabolic rate	0.2	1.1	2.2	0.8	1.5	1.5	0.3	0.7
Ever depressed for a whole week	0.2	0.3	0.3	0.6	0.3	0.6	-0.6	0.5
Unable to work because of sickness or disability	0.2	0.2	0.6	0.2	0.7	0.1	0.3	0.8
Pack years of smoking	0.2	0.4	1.0	-0.3	-0.2	-0.0	0.8	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.5	-0.4	0.9	0.4	-0.6
Major Depression (MDD)	0.1	0.2	0.6	-0.2	-0.0	-0.8	-0.5	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.4	-0.0	-0.3	0.3	-0.1	-0.6
Ovarian Cancer	0.1	0.2	0.5	0.2	-0.5	-0.0	-0.7	-0.4
Lung FVC	0.1	0.5	1.1	0.2	1.0	0.0	0.4	1.1
Chronotype (morning person)	0.1	0.3	0.9	-0.3	-0.7	-0.4	0.1	0.9
Hand grip strength (left)	0.1	0.3	0.8	-0.7	-0.3	-0.3	0.2	0.9
Number of treatments/medications taken	0.1	0.2	0.2	0.3	0.4	0.4	0.5	0.3
Average weekly spirits intake	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.5	-0.1
Sensitivity / hurt feelings	0.1	0.2	1.0	0.1	-1.0	-0.2	-0.4	0.3
Angina	0.1	0.2	0.4	0.2	0.1	0.5	-0.3	0.7
Diabetes (mother)	0.1	0.1	0.2	0.5	0.1	0.2	-0.3	-0.5
Average weekly fortified wine intake	0.1	0.1	0.4	-0.1	-0.3	0.6	0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.2	-0.4	0.0	-0.4	-0.2
Body mass index (BMI)	0.1	0.4	1.1	-0.4	0.7	-0.5	0.1	-1.0
Trunk fat mass	0.1	0.3	0.7	-0.4	0.8	-0.1	0.1	-0.8
Qualifications: None of the above	0.1	0.3	0.6	0.3	0.8	-0.1	-0.6	0.4
Mouth/teeth dental problems	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.4	-0.6
Weight	0.1	0.4	1.2	0.1	1.1	0.6	0.3	-0.2
Arm fat percentage (right)	0.1	0.3	0.9	-0.3	0.9	0.1	0.5	-0.6
Hip circumference	0.1	0.4	1.1	0.1	1.0	0.6	0.6	-0.5
Illnesses of mother	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.2	-0.3
Arm fat mass (right)	0.1	0.3	0.8	-0.2	0.9	0.1	-0.0	-0.7
Birth weight of first child	0.1	0.2	0.8	0.2	-0.2	-0.5	-0.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.3	-0.0	-0.3	0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.1	0.0	-0.0	0.3	0.6
Arm fat-free mass (right)	0.1	0.4	1.2	0.5	1.1	0.6	-0.4	-0.1
Number of children fathered	0.1	0.2	0.4	0.5	0.3	0.7	-0.1	-0.0
Qualifications: College or University degree	0.1	0.3	0.7	0.4	-0.2	0.7	0.0	-0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.2	0.4	-0.2	0.4	-0.6
Whole body fat mass	0.1	0.4	0.6	-0.8	0.6	-0.5	0.2	-0.8
Arm predicted mass (right)	0.1	0.4	1.4	0.4	1.2	0.7	-0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.3	0.5	-0.0	0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	-0.5	-0.1	-0.3	-0.2	-0.6
Arm fat percentage (left)	0.1	0.3	0.7	-0.4	0.9	-0.0	0.5	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.6	-0.2	0.0	0.7	-0.1
Back pain experienced in last month	0.1	0.2	0.6	0.0	0.1	-0.5	-0.4	-0.8
Medication: Aspirin	0.1	0.1	0.4	0.3	-0.6	-0.0	-0.3	0.0
Arm fat mass (left)	0.1	0.3	0.9	-0.2	1.0	0.0	0.2	-0.7
Number of self-reported non-cancer illnesses	0.1	0.3	1.0	1.0	0.2	0.3	0.3	0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.0	-0.3	0.7	-0.1	-0.4
Arm fat-free mass (left)	0.1	0.4	1.3	0.5	1.1	0.6	-0.4	-0.1
Leg fat mass (left)	0.1	0.5	1.0	-0.7	0.6	-0.8	-0.0	-1.0
Arm predicted mass (left)	0.1	0.3	1.1	0.3	1.0	0.5	-0.4	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.2	-0.4	0.5	-0.0	0.0	0.0
Exposure to tobacco smoke outside home	0.0	0.0	0.1	0.0	0.2	0.0	-0.3	-0.0
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.3	-0.3

Hub : Genes

FBXO24

Models

Trait associations