[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr12:109,973,273-113,517,494

Best TWAS P=7.04e-41 · Best GWAS P=1.75e-54 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
74	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	-8.66	13.4	7.0e-41	0.64	0.60	0.40	TRUE
90	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	-6.55	-9.3	1.0e-20	-0.60	0.01	0.75	TRUE
56	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	-6.33	9.2	2.6e-20	0.62	0.97	0.03	TRUE
65	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	-8.66	-8.8	2.1e-18	-0.54	0.30	0.52	TRUE
30	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	6.82	-7.4	1.3e-13	-0.34	0.03	0.23	TRUE
21	GTEx	Brain Cerebellar Hemisphere	ADAM1A	0.21	0.01	enet	29	0.03	6.8e-02	-5.27	6.4	1.5e-10	0.39	0.04	0.16	TRUE
50	GTEx	Pituitary	ADAM1A	0.18	0.22	enet	42	0.20	9.6e-06	-4.37	6.4	1.6e-10	0.35	0.81	0.03	TRUE
5	GTEx	Adipose Subcutaneous	PPTC7	0.09	0.00	enet	28	0.01	7.5e-02	-3.38	-5.5	3.1e-08	-0.05	0.07	0.04	TRUE
9	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	-2.71	-5.5	3.1e-08	-0.26	0.04	0.07	TRUE
71	NTR	Blood	GPN3	0.03	0.01	blup	236	0.02	2.7e-06	-4.32	5.4	8.0e-08	0.12	0.97	0.00	TRUE
20	GTEx	Brain Cerebellar Hemisphere	NAA25	0.11	0.02	enet	10	0.00	2.5e-01	-4.32	-5.3	1.0e-07	-0.33	0.14	0.06	TRUE
27	GTEx	Breast Mammary Tissue	VPS29	0.20	0.03	enet	33	0.08	5.2e-05	6.82	-5.3	1.1e-07	-0.25	0.05	0.74	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ATXN2	0.02	0.03	enet	8	0.02	4.8e-04	-8.62	11.0	3.2e-28	0.56	0.26	0.64	FALSE
17	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	11.19	10.6	3.5e-26	0.78	0.01	0.92	FALSE
66	GTEx	Thyroid	ALDH2	0.06	0.04	lasso	4	0.05	9.7e-05	-8.96	9.5	1.5e-21	0.47	0.88	0.07	FALSE
4	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	-6.38	9.4	7.9e-21	0.65	0.06	0.83	FALSE
7	GTEx	Adipose Subcutaneous	AC003029.1	0.08	0.07	enet	30	0.05	1.2e-04	-6.38	-8.3	1.3e-16	-0.47	1.00	0.00	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	MAPKAPK5-AS1	0.04	0.00	enet	30	0.00	7.0e-01	-6.39	-8.3	1.4e-16	-0.53	0.22	0.13	FALSE
36	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	-8.71	8.2	1.7e-16	0.41	0.06	0.06	FALSE
6	GTEx	Adipose Subcutaneous	MAPKAPK5-AS1	0.08	0.01	enet	26	0.03	2.1e-03	-8.60	-8.0	1.6e-15	-0.44	0.97	0.02	FALSE
13	GTEx	Artery Aorta	AC003029.1	0.07	0.01	lasso	7	0.01	5.4e-02	-8.96	-7.9	2.8e-15	-0.43	0.22	0.20	FALSE
51	GTEx	Pituitary	RP3-462E2.5	0.15	0.12	lasso	3	0.14	2.3e-04	-6.38	7.8	6.7e-15	0.43	0.23	0.05	FALSE
59	GTEx	Stomach	TMEM116	0.13	0.03	lasso	7	0.03	1.6e-02	-4.41	-7.8	8.5e-15	-0.46	0.07	0.15	FALSE
26	GTEx	Brain Putamen basal ganglia	ALDH2	0.12	0.00	lasso	14	0.02	1.3e-01	-9.24	7.7	1.1e-14	0.39	0.16	0.16	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ALDH2	0.05	0.11	blup	223	0.10	1.8e-12	-6.33	7.5	4.9e-14	0.42	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	FAM109A	0.26	0.06	lasso	4	0.07	9.5e-06	-9.24	7.2	4.5e-13	0.25	0.31	0.03	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	-7.13	-7.2	6.8e-13	-0.50	0.01	0.86	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	ALDH2	0.13	0.18	lasso	9	0.16	5.0e-09	-6.37	7.0	2.8e-12	0.40	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM116	0.03	0.03	blup	43	0.03	8.0e-05	-4.78	-7.0	3.2e-12	-0.43	0.52	0.21	FALSE
40	GTEx	Esophagus Mucosa	ALDH2	0.05	0.06	lasso	6	0.07	1.7e-05	-6.48	7.0	3.6e-12	0.43	0.93	0.04	FALSE
24	GTEx	Brain Frontal Cortex BA9	ALDH2	0.33	0.04	enet	24	0.09	2.0e-03	-9.10	6.9	3.9e-12	0.33	0.09	0.08	FALSE
16	GTEx	Artery Tibial	ALDH2	0.08	0.09	lasso	2	0.07	2.7e-06	-6.38	6.7	2.1e-11	0.41	0.94	0.02	FALSE
62	GTEx	Testis	BRAP	0.06	0.03	enet	13	0.01	8.7e-02	-6.48	-6.7	2.5e-11	-0.41	0.44	0.07	FALSE
41	GTEx	Esophagus Muscularis	HECTD4	0.06	0.03	lasso	4	0.02	1.8e-02	-6.48	6.7	2.8e-11	0.41	0.57	0.07	FALSE
44	GTEx	Lung	ALDH2	0.07	0.01	lasso	10	0.02	5.9e-03	-6.77	6.6	3.5e-11	0.39	0.38	0.03	FALSE
48	GTEx	Nerve Tibial	AC003029.1	0.04	0.00	lasso	23	0.00	4.2e-01	-4.45	-6.6	4.0e-11	-0.38	0.18	0.06	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf47	0.01	0.01	blup	31	0.01	7.3e-03	-6.38	-6.5	5.6e-11	-0.38	0.05	0.35	FALSE
11	GTEx	Adrenal Gland	AC003029.1	0.12	0.10	lasso	13	0.07	2.0e-03	-6.48	-6.5	6.6e-11	-0.39	0.79	0.04	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	-3.83	6.5	7.0e-11	0.44	0.01	0.91	FALSE
58	GTEx	Skin Sun Exposed Lower leg	AC003029.1	0.09	0.10	lasso	2	0.10	8.8e-09	-6.48	-6.5	7.1e-11	-0.39	1.00	0.00	FALSE
10	GTEx	Adrenal Gland	MAPKAPK5-AS1	0.10	0.08	lasso	12	0.03	3.0e-02	-6.48	-6.5	8.1e-11	-0.39	0.56	0.07	FALSE
25	GTEx	Brain Frontal Cortex BA9	TMEM116	0.10	0.09	lasso	7	0.18	1.9e-05	-6.77	-6.5	9.1e-11	-0.36	0.38	0.04	FALSE
68	GTEx	Thyroid	AC003029.1	0.04	0.05	lasso	3	0.04	8.3e-04	-6.37	-6.5	9.3e-11	-0.39	0.81	0.04	FALSE
57	GTEx	Skin Sun Exposed Lower leg	MAPKAPK5-AS1	0.09	0.10	lasso	4	0.10	1.1e-08	-6.38	-6.5	9.6e-11	-0.39	1.00	0.00	FALSE
42	GTEx	Esophagus Muscularis	MAPKAPK5-AS1	0.04	0.02	enet	7	0.02	2.7e-02	-6.47	-6.4	1.3e-10	-0.39	0.35	0.03	FALSE
45	GTEx	Nerve Tibial	ALDH2	0.05	0.04	lasso	3	0.05	2.4e-04	-6.48	6.4	1.3e-10	0.39	0.76	0.02	FALSE
86	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TMEM116	0.04	0.02	blup	43	0.02	3.5e-02	-4.46	-6.4	1.3e-10	-0.39	0.03	0.12	FALSE
63	GTEx	Testis	MAPKAPK5-AS1	0.07	0.04	lasso	1	0.03	1.3e-02	-6.39	-6.4	1.7e-10	-0.38	0.18	0.15	FALSE
67	GTEx	Thyroid	MAPKAPK5-AS1	0.04	0.04	lasso	2	0.03	1.5e-03	-6.37	-6.4	1.8e-10	-0.38	0.62	0.02	FALSE
28	GTEx	Breast Mammary Tissue	HECTD4	0.06	0.08	lasso	1	0.07	1.6e-04	-6.37	6.4	1.9e-10	0.38	0.31	0.20	FALSE
33	GTEx	Cells Transformed fibroblasts	AC003029.1	0.06	0.05	lasso	1	0.03	2.1e-03	-6.37	-6.4	1.9e-10	-0.38	0.66	0.02	FALSE
32	GTEx	Cells Transformed fibroblasts	MAPKAPK5-AS1	0.06	0.04	lasso	12	0.02	9.5e-03	-6.37	-6.4	2.1e-10	-0.38	0.53	0.03	FALSE
64	GTEx	Testis	AC003029.1	0.10	0.10	lasso	14	0.09	5.8e-05	-6.39	-6.4	2.1e-10	-0.38	0.63	0.13	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALDH2	0.03	0.03	lasso	1	0.03	3.1e-04	-6.33	6.3	2.5e-10	0.38	0.03	0.57	FALSE
22	GTEx	Brain Cerebellum	NAA25	0.12	-0.01	lasso	12	0.00	3.0e-01	-4.41	-6.3	2.8e-10	-0.34	0.12	0.07	FALSE
38	GTEx	Colon Transverse	AC003029.1	0.15	0.09	lasso	12	0.07	2.1e-04	-6.39	-6.3	3.0e-10	-0.39	0.81	0.02	FALSE
12	GTEx	Artery Aorta	ALDH2	0.05	0.04	enet	33	0.05	1.3e-03	-4.21	6.3	3.2e-10	0.38	0.60	0.08	FALSE
19	GTEx	Artery Tibial	AC003029.1	0.05	0.04	lasso	12	0.03	3.6e-03	-6.39	-6.3	3.5e-10	-0.38	0.58	0.04	FALSE
34	GTEx	Colon Sigmoid	MAPKAPK5-AS1	0.17	0.05	lasso	15	0.07	1.5e-03	-6.37	-6.3	3.6e-10	-0.37	0.51	0.06	FALSE
89	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALDH2	0.08	0.08	blup	32	0.09	2.3e-04	-6.37	6.3	3.9e-10	0.37	0.10	0.66	FALSE
37	GTEx	Colon Transverse	MAPKAPK5-AS1	0.16	0.09	lasso	13	0.06	7.1e-04	-6.37	-6.2	4.4e-10	-0.39	0.82	0.01	FALSE
61	GTEx	Testis	MAPKAPK5	0.23	0.12	lasso	5	0.15	3.1e-07	-4.21	6.2	5.0e-10	0.41	0.75	0.19	FALSE
14	GTEx	Artery Coronary	MAPKAPK5-AS1	0.16	0.10	lasso	13	0.06	5.7e-03	-6.37	-6.2	5.1e-10	-0.38	0.38	0.08	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALDH2	0.02	0.02	blup	31	0.01	1.2e-02	-6.59	6.2	6.6e-10	0.35	0.04	0.28	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	AC003029.1	0.06	0.03	lasso	3	0.04	1.9e-02	-5.76	-6.2	7.0e-10	-0.38	0.15	0.09	FALSE
79	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ALDH2	0.10	0.08	blup	30	0.09	4.5e-06	-6.26	6.2	7.4e-10	0.36	0.18	0.78	FALSE
8	GTEx	Adipose Visceral Omentum	RP3-462E2.5	0.15	0.07	enet	8	0.07	1.0e-04	-5.27	6.1	8.0e-10	0.28	0.61	0.13	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf47	0.07	0.04	lasso	2	0.03	1.0e-04	-6.17	-6.1	1.0e-09	-0.36	0.08	0.89	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf47	0.02	0.01	blup	31	0.02	1.7e-03	-6.37	-6.1	1.3e-09	-0.36	0.07	0.49	FALSE
70	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	-0.74	-6.0	1.6e-09	-0.43	0.99	0.00	FALSE
29	GTEx	Breast Mammary Tissue (Male)	RP3-462E2.3	0.12	0.03	lasso	7	0.04	4.0e-02	-4.04	-6.0	1.8e-09	-0.39	0.02	0.06	FALSE
31	GTEx	Cells Transformed fibroblasts	HECTD4	0.04	0.01	lasso	5	0.00	4.5e-01	-4.31	6.0	2.0e-09	0.35	0.22	0.04	FALSE
35	GTEx	Colon Sigmoid	AC003029.1	0.17	0.08	lasso	14	0.09	3.8e-04	-6.37	-6.0	2.2e-09	-0.35	0.60	0.06	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAPKAPK5	0.03	0.01	blup	42	0.01	2.5e-02	-4.21	5.9	2.8e-09	0.37	0.05	0.51	FALSE
23	GTEx	Brain Cerebellum	HECTD4	0.25	-0.01	enet	24	0.06	7.7e-03	-1.20	5.9	3.1e-09	0.42	0.06	0.70	FALSE
49	GTEx	Nerve Tibial	RP3-462E2.3	0.12	0.03	lasso	7	0.03	2.7e-03	-3.83	-5.9	3.1e-09	-0.32	0.93	0.00	FALSE
88	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM116	0.12	0.07	blup	43	0.10	7.6e-05	-4.46	-5.8	5.0e-09	-0.37	0.36	0.21	FALSE
46	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	-5.81	5.8	6.8e-09	0.41	0.23	0.43	FALSE
75	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	4.06	5.8	8.4e-09	0.55	0.08	0.87	FALSE
52	GTEx	Prostate	ADAM1A	0.30	0.11	lasso	16	0.12	5.4e-04	-4.77	5.7	1.4e-08	0.34	0.48	0.24	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NAA25	0.03	0.02	blup	213	0.03	1.1e-04	-4.46	-5.6	1.7e-08	-0.33	0.74	0.02	FALSE
15	GTEx	Artery Coronary	AC003029.1	0.14	0.12	enet	39	0.07	1.8e-03	-6.37	-5.6	1.9e-08	-0.34	0.61	0.05	FALSE
43	GTEx	Esophagus Muscularis	RP3-462E2.5	0.06	0.04	lasso	14	0.03	4.6e-03	-4.46	5.6	1.9e-08	0.32	0.75	0.02	FALSE
72	YFS	Blood	ACAD10	0.07	0.01	bslmm	241	0.02	4.3e-08	-5.81	-5.5	2.9e-08	-0.41	0.08	0.46	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	ALDH2	0.03	0.02	blup	31	0.02	6.4e-03	-6.62	5.5	3.7e-08	0.32	0.05	0.43	FALSE
80	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM116	0.04	0.04	enet	13	0.04	2.7e-03	-4.41	-5.5	4.1e-08	-0.31	0.05	0.12	FALSE
18	GTEx	Artery Tibial	MAPKAPK5-AS1	0.07	0.05	lasso	11	0.05	9.7e-05	-4.46	-5.5	4.8e-08	-0.33	0.76	0.02	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf47	0.04	0.03	blup	31	0.02	2.8e-03	-6.59	-5.4	7.1e-08	-0.30	0.06	0.55	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRPV4	0.05	0.03	enet	15	0.04	2.1e-05	1.80	5.4	7.8e-08	0.12	0.00	0.01	FALSE
73	YFS	Blood	ATXN2	0.05	0.02	blup	257	0.04	2.8e-12	-5.27	-5.4	8.4e-08	-0.28	1.00	0.00	FALSE
69	GTEx	Whole Blood	ADAM1A	0.08	0.02	lasso	10	0.01	2.7e-02	-4.46	5.2	1.8e-07	0.31	0.38	0.27	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP3-462E2.5	0.10	0.10	enet	17	0.11	1.2e-06	-4.46	5.2	2.5e-07	0.29	0.99	0.00	FALSE
91	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM116	0.17	0.06	blup	43	0.05	5.6e-03	-4.46	-5.1	2.7e-07	-0.34	0.09	0.20	FALSE
60	GTEx	Stomach	AC003029.1	0.10	0.03	enet	32	0.02	2.6e-02	-6.37	-5.1	2.9e-07	-0.34	0.47	0.06	FALSE