[Hub]/) : Traits : Pulse rate : ← →

chr7:99,060,603-101,185,166

Best TWAS P=1.21e-28 · Best GWAS P=8.19e-26 conditioned to 0.125

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	GTEx	Heart Atrial Appendage	GIGYF1	0.12	0.07	lasso	8	0.05	2.8e-03	10.427	11.1	1.2e-28	0.88	0.02	0.86	TRUE
44	GTEx	Ovary	GIGYF1	0.23	0.15	lasso	5	0.14	2.9e-04	10.068	11.0	4.6e-28	0.80	0.02	0.90	FALSE
71	YFS	Blood	TRIP6	0.08	0.10	lasso	6	0.11	6.7e-35	10.427	-10.7	1.2e-26	-0.94	0.01	0.99	FALSE
40	GTEx	Nerve Tibial	ACHE	0.28	0.23	lasso	7	0.22	6.1e-16	10.427	10.6	3.8e-26	0.98	0.01	0.99	FALSE
12	GTEx	Artery Tibial	ACHE	0.10	0.09	lasso	5	0.08	9.2e-07	10.505	10.5	8.2e-26	1.00	0.01	0.99	FALSE
29	GTEx	Heart Atrial Appendage	ACHE	0.19	0.19	lasso	2	0.18	2.6e-08	10.427	10.5	1.3e-25	0.97	0.01	0.99	FALSE
51	GTEx	Skin Sun Exposed Lower leg	ACHE	0.07	0.10	lasso	1	0.09	3.5e-08	10.427	10.4	1.9e-25	0.98	0.01	0.99	FALSE
41	GTEx	Nerve Tibial	SRRT	0.13	0.12	lasso	4	0.11	3.7e-08	10.311	10.4	2.3e-25	0.98	0.01	0.99	FALSE
30	GTEx	Heart Atrial Appendage	SRRT	0.14	0.01	enet	10	0.02	4.5e-02	10.427	10.3	5.3e-25	0.93	0.01	0.89	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	ACHE	0.04	0.04	lasso	2	0.03	3.0e-04	10.311	10.3	5.5e-25	0.98	0.01	0.98	FALSE
8	GTEx	Artery Aorta	ACHE	0.35	0.31	enet	35	0.32	1.9e-18	10.422	10.2	2.5e-24	0.91	0.01	0.99	FALSE
37	GTEx	Muscle Skeletal	GIGYF1	0.10	0.03	enet	14	0.06	6.8e-07	7.944	10.0	1.7e-23	0.56	0.60	0.38	FALSE
79	The Cancer Genome Atlas	Glioblastoma Multiforme	EPHB4	0.16	0.11	enet	7	0.07	3.8e-03	10.505	-9.9	2.8e-23	-0.97	0.00	0.91	FALSE
3	GTEx	Adipose Subcutaneous	GIGYF1	0.14	0.10	enet	22	0.14	1.9e-11	8.002	9.9	3.5e-23	0.50	1.00	0.00	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	GIGYF1	0.11	0.00	lasso	5	0.00	2.2e-01	8.331	9.8	1.2e-22	0.67	0.04	0.61	FALSE
76	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UFSP1	0.09	0.03	blup	53	0.05	1.2e-03	6.379	-9.4	4.2e-21	-0.80	0.02	0.58	FALSE
24	GTEx	Esophagus Mucosa	ACHE	0.08	0.03	lasso	9	0.03	2.2e-03	6.188	9.4	7.0e-21	0.75	0.03	0.92	FALSE
20	GTEx	Cells Transformed fibroblasts	GIGYF1	0.21	0.16	lasso	9	0.19	6.2e-14	8.002	9.2	2.6e-20	0.49	1.00	0.00	FALSE
46	GTEx	Prostate	GIGYF1	0.51	0.06	lasso	10	0.05	2.0e-02	7.745	9.2	4.5e-20	0.54	0.05	0.35	FALSE
10	GTEx	Artery Aorta	GIGYF1	0.14	0.11	enet	9	0.11	1.1e-06	8.002	9.0	2.4e-19	0.48	0.53	0.33	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	GIGYF1	0.04	0.03	blup	29	0.03	1.7e-04	8.089	8.9	4.8e-19	0.43	0.00	0.95	FALSE
89	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EPHB4	0.20	0.07	blup	50	0.10	6.9e-05	7.553	-8.9	5.4e-19	-0.80	0.02	0.74	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	GIGYF1	0.03	0.02	blup	30	0.02	4.7e-03	7.745	8.9	5.6e-19	0.42	0.01	0.79	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	GIGYF1	0.29	0.09	lasso	3	0.12	5.6e-05	8.089	8.8	2.1e-18	0.45	0.66	0.07	FALSE
35	GTEx	Lung	GIGYF1	0.25	0.13	lasso	7	0.14	4.0e-11	7.993	8.7	2.3e-18	0.45	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	GIGYF1	0.04	0.03	blup	30	0.03	8.4e-04	7.745	8.7	3.3e-18	0.41	0.01	0.81	FALSE
64	GTEx	Whole Blood	GIGYF1	0.04	0.02	lasso	5	0.01	5.5e-02	7.944	8.7	4.0e-18	0.46	0.10	0.41	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	TRIP6	0.11	0.02	lasso	6	0.01	1.3e-01	-5.772	8.6	8.8e-18	0.54	0.08	0.29	FALSE
60	GTEx	Thyroid	GIGYF1	0.33	0.24	lasso	7	0.24	1.5e-18	7.993	8.6	9.2e-18	0.47	1.00	0.00	FALSE
25	GTEx	Esophagus Mucosa	GIGYF1	0.10	0.01	enet	15	0.07	1.0e-05	8.002	8.6	9.8e-18	0.46	0.33	0.43	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	SLC12A9	0.07	0.05	lasso	4	0.07	7.6e-10	-5.932	8.6	1.0e-17	0.65	0.88	0.12	FALSE
15	GTEx	Brain Cerebellar Hemisphere	SLC12A9	0.17	0.07	lasso	5	0.00	4.5e-01	-5.878	8.6	1.2e-17	0.60	0.04	0.63	FALSE
19	GTEx	Breast Mammary Tissue	GIGYF1	0.23	0.07	enet	14	0.09	2.4e-05	7.993	8.5	2.1e-17	0.42	0.26	0.13	FALSE
18	GTEx	Brain Putamen basal ganglia	GIGYF1	0.31	-0.01	lasso	5	-0.01	5.1e-01	7.983	8.4	3.5e-17	0.40	0.07	0.09	FALSE
14	GTEx	Artery Tibial	GIGYF1	0.13	0.04	enet	23	0.05	1.5e-04	7.983	8.4	3.8e-17	0.53	0.38	0.05	FALSE
52	GTEx	Skin Sun Exposed Lower leg	GIGYF1	0.11	0.07	enet	12	0.09	1.4e-07	7.983	8.4	3.8e-17	0.42	0.97	0.00	FALSE
59	GTEx	Thyroid	ACHE	0.19	0.10	enet	33	0.14	1.5e-10	10.505	8.4	4.3e-17	0.78	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	GIGYF1	0.12	0.07	lasso	3	0.04	5.0e-03	7.993	8.3	7.6e-17	0.43	0.08	0.35	FALSE
33	GTEx	Heart Left Ventricle	GIGYF1	0.09	0.02	lasso	4	0.02	2.0e-02	8.089	8.3	8.6e-17	0.43	0.12	0.16	FALSE
43	GTEx	Nerve Tibial	GIGYF1	0.17	0.14	enet	7	0.14	2.3e-10	7.944	8.2	3.0e-16	0.43	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GNB2	0.03	0.01	blup	31	0.02	1.3e-03	7.983	-8.1	4.2e-16	-0.43	0.01	0.69	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACHE	0.03	0.01	blup	56	0.01	1.8e-03	9.974	8.1	5.4e-16	0.83	0.01	0.72	FALSE
9	GTEx	Artery Aorta	SRRT	0.11	0.09	enet	20	0.09	1.4e-05	10.505	8.0	8.8e-16	0.78	0.00	0.99	FALSE
6	GTEx	Adrenal Gland	GIGYF1	0.23	0.14	lasso	1	0.07	1.2e-03	8.002	8.0	1.2e-15	0.42	0.15	0.24	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	GIGYF1	0.05	0.06	lasso	3	0.06	4.7e-07	7.944	7.9	2.0e-15	0.42	0.01	0.99	FALSE
66	METSIM	Adipose	GIGYF1	0.15	0.08	blup	297	0.13	3.9e-19	6.764	7.8	9.0e-15	0.34	1.00	0.00	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	SRRT	0.05	0.02	bslmm	331	0.02	1.1e-03	10.505	7.7	2.0e-14	0.83	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GIGYF1	0.08	0.01	blup	295	0.06	9.2e-08	7.944	7.6	2.5e-14	0.46	0.43	0.18	FALSE
57	GTEx	Testis	GIGYF1	0.23	0.05	enet	17	0.17	7.4e-08	7.983	7.6	2.6e-14	0.38	0.88	0.01	FALSE
53	GTEx	Skin Sun Exposed Lower leg	UFSP1	0.06	0.01	lasso	4	0.02	3.5e-03	-4.891	-7.6	3.6e-14	-0.36	0.28	0.06	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	EPHB4	0.05	0.04	lasso	1	0.02	2.8e-03	7.553	-7.5	4.3e-14	-0.65	0.14	0.08	FALSE
27	GTEx	Esophagus Muscularis	GIGYF1	0.22	0.12	enet	13	0.15	3.3e-09	8.002	7.5	5.3e-14	0.35	0.99	0.00	FALSE
17	GTEx	Brain Putamen basal ganglia	STAG3	0.36	0.03	lasso	12	0.09	3.1e-03	7.944	7.5	5.8e-14	0.33	0.02	0.85	FALSE
21	GTEx	Colon Transverse	GIGYF1	0.20	0.05	enet	19	0.09	4.9e-05	7.993	7.5	6.9e-14	0.37	0.54	0.02	FALSE
67	NTR	Blood	UFSP1	0.01	0.00	blup	344	0.00	6.5e-02	-5.932	-7.5	7.8e-14	-0.42	0.29	0.05	FALSE
45	GTEx	Pituitary	GIGYF1	0.24	0.01	lasso	7	0.03	5.7e-02	6.749	7.4	1.2e-13	0.43	0.10	0.05	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	GIGYF1	0.10	0.02	bslmm	279	0.07	4.6e-09	-5.668	7.4	1.2e-13	0.51	0.96	0.04	FALSE
39	GTEx	Nerve Tibial	TRIP6	0.10	0.08	enet	23	0.11	3.9e-08	-5.932	7.3	2.0e-13	0.58	0.77	0.18	FALSE
72	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIP6	0.12	0.03	enet	16	0.08	3.9e-07	-2.214	-7.3	2.9e-13	-0.71	0.06	0.92	FALSE
91	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EPHB4	0.30	0.20	lasso	5	0.18	8.1e-07	7.553	7.3	3.8e-13	0.66	0.12	0.81	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	EPO	0.03	0.00	blup	33	0.00	1.4e-01	7.944	-7.2	6.4e-13	-0.39	0.01	0.54	FALSE
54	GTEx	Spleen	GIGYF1	0.22	0.00	enet	19	0.10	1.3e-03	8.089	7.1	1.0e-12	0.27	0.13	0.05	FALSE
36	GTEx	Muscle Skeletal	TRIP6	0.08	0.07	lasso	4	0.07	5.3e-07	7.224	7.1	1.2e-12	0.54	0.43	0.54	FALSE
56	GTEx	Stomach	GIGYF1	0.24	0.03	lasso	5	0.07	4.7e-04	7.745	7.1	1.2e-12	0.32	0.24	0.33	FALSE
7	GTEx	Artery Aorta	TRIP6	0.10	0.05	enet	15	0.04	3.3e-03	-5.769	7.1	1.3e-12	0.56	0.25	0.54	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	TFR2	0.02	0.01	blup	33	0.02	2.6e-04	-4.223	7.0	2.8e-12	0.29	0.16	0.33	FALSE
55	GTEx	Stomach	TFR2	0.10	0.03	lasso	6	0.07	4.1e-04	6.712	-6.8	7.2e-12	-0.30	0.13	0.07	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	EPO	0.07	0.02	blup	33	0.04	1.5e-08	-4.104	6.8	9.0e-12	0.33	0.20	0.69	FALSE
28	GTEx	Heart Atrial Appendage	TRIP6	0.34	0.05	lasso	7	0.08	2.3e-04	-5.932	6.8	1.4e-11	0.57	0.11	0.62	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	TFR2	0.11	0.06	lasso	6	0.04	2.2e-03	6.742	6.7	1.6e-11	0.39	0.16	0.06	FALSE
88	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UFSP1	0.10	0.06	enet	7	0.04	9.9e-03	6.128	-6.5	6.8e-11	-0.40	0.03	0.08	FALSE
58	GTEx	Testis	PPP1R35	0.15	0.01	lasso	7	0.00	2.1e-01	-4.646	6.5	8.1e-11	0.21	0.11	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRIP6	0.05	0.01	blup	350	0.01	1.9e-02	-1.008	6.4	1.2e-10	0.49	0.09	0.47	FALSE
61	GTEx	Thyroid	UFSP1	0.06	0.04	lasso	8	0.03	4.3e-03	6.188	-6.4	2.1e-10	-0.49	0.51	0.04	FALSE
26	GTEx	Esophagus Mucosa	UFSP1	0.13	0.10	lasso	5	0.09	7.3e-07	-5.822	-6.3	2.5e-10	-0.40	0.96	0.01	FALSE
42	GTEx	Nerve Tibial	SLC12A9	0.23	0.12	enet	8	0.12	5.4e-09	-5.932	6.3	3.1e-10	0.44	1.00	0.00	FALSE
32	GTEx	Heart Atrial Appendage	UFSP1	0.11	0.06	lasso	5	0.03	2.0e-02	-5.189	-6.2	7.9e-10	-0.35	0.23	0.05	FALSE
22	GTEx	Colon Transverse	UFSP1	0.12	0.08	enet	10	0.04	5.1e-03	-5.750	-6.1	1.3e-09	-0.47	0.53	0.05	FALSE
38	GTEx	Muscle Skeletal	UFSP1	0.08	0.04	lasso	5	0.02	8.6e-03	-5.822	-6.1	1.3e-09	-0.45	0.85	0.02	FALSE
65	GTEx	Whole Blood	UFSP1	0.06	0.05	enet	4	0.05	1.9e-05	-5.848	-6.0	1.6e-09	-0.44	0.92	0.02	FALSE
34	GTEx	Lung	TRIP6	0.06	0.04	enet	12	0.04	6.9e-04	-5.822	5.9	2.8e-09	0.42	0.76	0.04	FALSE
13	GTEx	Artery Tibial	SRRT	0.14	0.02	enet	12	0.02	8.8e-03	-2.114	5.8	7.2e-09	0.64	0.05	0.80	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	UFSP1	0.03	0.05	blup	53	0.03	8.7e-03	-5.769	-5.7	1.3e-08	-0.42	0.07	0.07	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	GPC2	0.15	0.11	enet	17	0.11	9.1e-07	3.890	-5.6	2.1e-08	-0.17	0.97	0.01	FALSE
11	GTEx	Artery Coronary	MEPCE	0.15	0.02	lasso	12	0.05	8.5e-03	0.044	5.6	2.5e-08	0.27	0.08	0.07	FALSE
62	GTEx	Vagina	RP11-758P17.3	0.44	-0.01	enet	37	0.04	4.7e-02	3.761	-5.6	2.5e-08	-0.40	0.03	0.15	FALSE
4	GTEx	Adipose Subcutaneous	UFSP1	0.07	0.02	enet	13	0.01	4.6e-02	6.128	-5.5	3.9e-08	-0.34	0.58	0.02	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	STAG3	0.25	0.28	lasso	7	0.28	3.8e-08	3.802	5.5	3.9e-08	0.25	0.52	0.35	FALSE
85	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TFR2	0.08	0.03	blup	34	0.06	1.3e-03	2.467	5.4	6.0e-08	0.33	0.01	0.28	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	GAL3ST4	0.20	0.03	enet	26	0.09	1.6e-05	6.717	-5.4	6.4e-08	-0.32	0.31	0.33	FALSE
63	GTEx	Whole Blood	ACHE	0.08	0.00	enet	11	0.02	9.2e-03	5.881	5.2	1.5e-07	0.42	0.08	0.38	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AGFG2	0.04	0.00	blup	28	0.02	1.5e-03	-2.525	-5.2	1.8e-07	-0.20	0.00	0.05	FALSE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZAN	0.08	0.12	lasso	4	0.10	1.4e-11	-5.155	-5.1	2.7e-07	-0.28	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POP7	0.03	0.00	enet	12	0.02	2.3e-03	-3.840	-5.1	2.9e-07	-0.28	0.01	0.45	FALSE