Hub : Genes

CLDN23

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1870	0.0600	1.4e-03	0.025	NA	0.026	NA	0.037	8.1e-03	NA	7.2e-03	NA	1.7e-03
2	GTEx	Lung	0.1796	0.0452	3.7e-08	0.167	NA	0.149	NA	0.161	9.1e-13	NA	1.8e-11	NA	2.5e-12
3	GTEx	Skin Not Sun Exposed Suprapubic	0.4160	0.0660	2.3e-10	0.305	NA	0.288	NA	0.299	3.4e-17	NA	3.7e-16	NA	7.6e-17
4	GTEx	Skin Sun Exposed Lower leg	0.4300	0.0510	0.0e+00	0.382	NA	0.389	NA	0.390	2.6e-33	NA	5.0e-34	NA	3.7e-34
5	GTEx	Testis	0.2040	0.0760	7.6e-03	0.006	NA	0.074	NA	0.031	1.7e-01	NA	3.5e-04	NA	1.6e-02
6	GTEx	Thyroid	0.1360	0.0480	1.1e-03	0.029	NA	0.015	NA	0.035	2.6e-03	NA	2.3e-02	NA	1.1e-03
7	METSIM	Adipose	0.0972	0.0350	7.5e-04	0.020	0.024	0.031	0.032	0.020	4.6e-04	1.3e-04	1.6e-05	1.1e-05	5.3e-04
8	YFS	Blood	0.4054	0.0345	0.0e+00	0.189	0.237	0.269	0.267	0.260	1.5e-59	2.6e-76	3.2e-88	2.2e-87	6.9e-85
9	TCGA	Brain Lower Grade Glioma	0.0626	0.0252	2.8e-05	0.025	0.024	0.021	NA	0.020	6.5e-04	8.0e-04	1.7e-03	NA	2.0e-03
10	TCGA	Lung Adenocarcinoma	0.0536	0.0258	4.2e-05	0.043	0.024	0.023	NA	0.021	7.3e-06	6.8e-04	9.0e-04	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.4	2.8	-0.0	-0.5	-0.2	-0.3	-0.4	-1.7	-0.7	0.8	-0.1	-0.0
Bipolar Disorder or Schizophrenia	0.8	1.9	4.7	-1.2	-1.7	-1.3	-1.3	-1.1	-2.2	-0.4	1.8	0.7	-0.9
Depressed Affect (Nagel 2018)	0.6	1.2	2.4	1.0	1.6	1.0	1.1	-0.1	1.5	1.0	-0.9	0.8	1.2
Depression (Nagel 2018)	0.5	0.8	2.1	0.3	1.0	0.9	0.9	-0.4	1.4	0.9	-1.3	0.1	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.1	0.5	0.6	0.3	0.3	-0.3	-0.4	0.8	1.1	-0.0	0.1
Neuroticism (Nagel 2018)	1.1	2.6	5.1	1.4	2.0	1.7	1.7	-0.6	2.3	1.5	-0.7	1.6	1.8
Schizophrenia (2018)	0.9	1.8	3.4	-1.5	-1.8	-1.5	-1.5	-1.1	-1.4	-0.0	1.7	1.0	-1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-0.3	-0.5	-0.3	-0.2	-0.9	0.4	-0.8	-0.3	1.0	-0.7
Worry (Nagel 2018)	1.0	2.1	4.8	1.4	1.5	1.4	1.4	-1.0	2.2	0.7	0.1	2.1	1.2
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	-1.0	-0.8	-0.9	-0.9	1.2	-0.5	1.5	0.8	-0.5	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.8	-0.1	-0.3	-0.3	-0.3	-0.1	-0.1	0.9	0.2	-0.2	-0.1
Alzheimer’s Disease (including proxy)	0.7	1.1	5.1	-0.9	-0.6	-1.0	-0.9	1.1	-0.1	2.3	0.7	-0.9	-0.3
Crohns Disease (2017)	0.3	0.6	4.3	0.3	0.1	0.3	0.3	-0.8	-0.1	-0.4	0.9	2.1	0.5
Irritable Bowel Disease (IBD)	0.4	1.0	5.6	-0.3	-0.2	-0.2	-0.3	0.3	0.2	1.6	2.4	1.0	0.3
Ulcerative Colitis (UC)	0.7	1.3	7.8	-0.3	-0.1	-0.2	-0.3	0.8	0.5	2.1	2.8	0.2	0.3
Major Depression (MDD)	0.2	0.2	0.6	-0.3	-0.3	-0.5	-0.5	0.7	-0.2	0.6	0.8	-0.0	0.0
Reaction Time	0.3	0.6	1.2	0.9	0.8	1.1	1.1	-0.4	0.8	0.3	-1.1	0.2	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.5	1.0	0.8	0.6	0.6	-0.2	0.0	0.8	2.1	0.2	0.6
Breast Cancer	0.5	1.3	3.2	-1.0	-1.5	-1.2	-1.2	0.0	-0.9	-0.1	-1.8	-1.1	-1.1
Ovarian Cancer	0.9	1.2	2.9	-1.2	-1.4	-1.2	-1.2	1.0	-0.6	0.0	-1.2	-0.1	-1.7
Prostate Cancer	1.4	1.9	4.1	-2.0	-1.9	-1.8	-1.8	0.8	-0.1	1.3	0.5	-0.3	-1.5
Age at First Birth	0.6	0.8	2.8	0.8	1.0	0.9	1.0	-0.6	0.2	-1.2	-1.7	-0.2	-0.0
Bipolar Disorder (2011)	0.4	0.4	1.4	-0.7	-0.5	-0.5	-0.5	0.4	-1.2	-0.6	0.4	-0.7	-0.4
Body Mass Index (BMI) (2010)	0.4	0.6	2.0	-0.6	-0.7	-0.5	-0.5	-0.6	-0.3	0.9	1.4	0.9	0.2
Coronary Artery Disease (CAD)	0.8	0.9	2.1	-0.6	-0.7	-1.1	-1.2	1.5	-0.9	0.6	0.0	-0.7	-1.3
Crohns Disease (2012)	0.4	0.6	3.0	-0.4	-0.4	-0.3	-0.3	0.6	-0.6	0.5	1.3	1.7	-0.0
Mean Putamen Volume	0.7	0.8	2.3	-1.5	-1.1	-0.9	-0.9	0.3	-0.4	1.2	0.8	0.1	-1.0
Fasting Glucose	0.3	0.3	1.4	-0.5	-0.6	-0.5	-0.5	0.0	-0.8	-0.5	1.2	-0.3	-0.0
HbA1C	4.7	5.3	10.5	-2.2	-2.9	-2.7	-2.7	1.4	-2.6	1.3	-0.9	-1.7	-3.2
HDL Cholesterol	0.3	0.5	1.0	0.4	0.2	0.3	0.3	1.0	0.8	0.9	0.9	0.7	1.0
LDL Cholesterol	1.5	2.3	5.2	-2.0	-1.6	-1.8	-1.9	1.1	-1.6	0.4	-0.1	-0.9	-2.3
Lupus	3.1	4.7	7.8	-2.3	-2.8	-2.6	-2.6	0.4	-2.3	1.6	2.8	0.5	-2.0
Neuroticism (2016)	4.5	6.5	17.5	2.0	3.9	3.2	3.2	0.5	4.2	0.2	-1.1	-0.4	2.7
Primary Biliary Cirrhosis	0.4	0.6	2.2	-0.2	-0.9	-0.7	-0.7	-1.2	-0.2	0.2	0.8	1.5	-0.5
Rheumatoid Arthritis	0.1	0.2	1.1	-0.5	-0.4	-0.2	-0.2	0.1	0.1	0.1	-1.0	-0.2	-0.3
Schizophrenia (2014)	0.6	1.3	2.4	-0.6	-1.2	-0.8	-0.8	-1.5	-1.3	-1.4	1.2	1.3	-0.6
Triglycerides	2.4	3.9	8.0	1.9	2.8	2.3	2.4	-1.6	2.4	-1.1	-0.2	1.1	2.2
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.7	-1.1	-1.5	-1.6	-1.6	1.1	-1.2	0.7	0.8	0.1	-1.0
Ulcerative Colitis	1.2	1.7	7.4	-0.9	0.1	-0.3	-0.3	2.1	0.7	2.7	1.6	-1.1	-0.0
Blood Eosinophil Count	0.0	0.2	0.4	0.5	0.4	-0.4	-0.3	0.1	-0.3	0.6	-0.3	-0.5	-0.4
Blood Platelet Count	0.2	2.6	6.2	-1.4	-1.3	-1.5	-1.5	1.5	-0.9	1.6	-1.9	-2.5	-1.7
Blood Red Count	0.1	1.0	3.4	1.1	0.4	1.0	1.0	-0.8	0.3	-0.1	1.1	1.9	1.2
Blood White Count	0.1	0.6	3.2	-0.6	-0.8	-0.6	-0.5	0.7	-0.7	1.8	0.0	-0.3	-0.2
Heel T-Score	0.4	3.3	6.2	-1.9	-2.3	-1.9	-1.9	2.2	-2.3	-0.8	-0.1	-0.8	-2.5
BMI	0.0	0.3	1.0	0.4	-0.1	0.3	0.2	0.6	0.0	0.8	-0.6	1.0	0.4
Height	0.7	14.1	19.8	4.0	3.7	4.2	4.2	-4.5	2.4	-4.4	-0.0	4.4	3.4
Waist Hip Ratio (WHR)	0.8	3.7	6.1	-2.5	-2.3	-2.4	-2.4	1.4	-2.3	0.9	0.3	-1.3	-2.1
Systolic Blood Pressure	0.2	1.1	2.6	-0.6	-1.2	-0.9	-1.0	1.1	-1.5	1.2	0.0	-0.7	-1.6
Smoking Status	0.7	1.6	9.4	1.2	0.5	0.8	0.8	-0.5	1.1	-0.1	1.2	3.1	1.0
Allergy or Eczema	1.2	3.2	5.9	2.0	1.8	2.2	2.1	-2.4	1.4	-1.2	-1.4	1.2	1.8
Cardiovascular Disease	0.1	0.4	1.6	0.5	0.7	0.6	0.6	0.3	-0.1	1.3	0.7	0.0	0.3
Hypothyroidism (self reported)	0.8	1.9	6.7	-1.0	-0.7	-1.2	-1.2	1.7	-1.3	2.6	-0.2	-1.3	-1.4
Respiratory disease	0.1	0.3	1.5	-0.0	-0.2	-0.3	-0.3	1.2	-0.7	-0.1	0.9	-0.2	0.3
Type 2 Diabetes (T2D) (2018)	1.5	2.8	5.8	1.6	1.9	1.4	1.4	-1.3	1.7	0.2	2.4	2.3	1.6
Lung FEV1/FVC ratio	0.5	2.7	8.7	1.7	1.4	1.5	1.4	-0.7	1.6	0.1	2.2	3.0	1.3
Lung FVC	0.2	1.1	3.7	0.7	0.8	0.9	0.8	-1.3	1.7	-0.1	-1.9	-0.0	0.0
Neuroticism	0.4	1.0	1.8	0.7	1.2	0.9	0.9	-0.8	1.3	1.0	-0.3	1.3	0.9
Chronotype (morning person)	0.2	0.4	3.1	0.1	-0.2	0.3	0.2	0.6	0.6	-1.8	-0.1	-0.2	-0.3
Hair Pigment	0.0	1.2	2.8	0.5	1.1	1.1	1.1	-1.7	1.4	-1.5	-0.3	1.0	0.3
Tanning	0.1	0.8	4.3	0.4	-0.2	0.1	0.1	0.2	-1.2	-2.1	-1.2	0.1	-0.2
Hand grip strength (left)	0.3	0.7	2.0	-1.0	-0.9	-0.8	-0.8	-0.4	-0.1	1.4	1.2	0.5	-0.3
Number of treatments/medications taken	0.7	1.2	5.4	0.9	0.4	0.4	0.4	-1.3	0.2	0.5	1.8	2.3	0.7
Average weekly spirits intake	0.2	0.2	0.8	0.2	0.6	0.6	0.5	0.9	0.5	0.3	0.4	0.3	0.3
Sensitivity / hurt feelings	5.6	9.7	20.1	2.8	4.5	3.9	3.9	-0.6	4.3	0.2	0.1	1.8	4.0
Frequency of depressed mood in last 2 weeks	2.1	3.0	6.1	0.9	2.5	1.8	1.9	-0.2	2.5	0.9	-2.5	-0.8	1.6
Hearing difficulty/problems: Yes	3.0	4.6	6.9	2.3	2.6	2.6	2.6	-2.0	2.6	-1.3	-1.4	0.9	2.2
Relative age of first facial hair	0.1	0.3	0.9	-0.1	-0.2	0.0	0.0	-0.0	0.9	0.3	-1.0	-0.4	-0.7
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.7	0.9	1.1	0.9	0.9	-0.7	0.8	0.6	0.9	1.6	1.1
Ever used hormone-replacement therapy (HRT)	6.9	8.7	15.4	-3.3	-3.9	-3.5	-3.5	2.6	-3.8	0.4	-0.4	-2.3	-3.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.3	-0.3	-1.5	-1.0	-1.0	-0.3	-1.5	-1.2	-0.2	-0.3	-0.9
Systolic blood pressure, automated reading	4.2	12.2	26.2	-3.3	-5.1	-4.4	-4.4	1.8	-4.8	2.1	1.6	-0.5	-3.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.1	-0.1	-0.3	-0.2	-0.2	1.0	-0.3	-0.1	0.2	0.6	-0.6
Angina	0.9	1.2	3.2	-1.0	-1.2	-1.0	-1.1	1.2	-1.8	1.1	-0.3	-0.3	-1.0
Medication for hormone replacement therapy	5.3	5.9	9.8	-2.8	-3.0	-2.8	-2.8	2.2	-3.1	0.8	-0.0	-1.9	-2.8
Vitamin and mineral supplements	0.9	1.2	2.6	1.1	1.3	0.8	0.9	-0.4	1.4	0.8	1.6	0.4	1.5
Supplements: Zinc	0.9	1.0	2.5	-0.6	-1.3	-1.2	-1.3	0.4	-1.6	-0.2	0.2	0.2	-1.5
Medication: Co-codamol	1.2	1.3	3.1	-1.0	-1.5	-1.8	-1.7	-0.5	-0.9	0.5	-0.4	-0.7	-1.4
Medication: Metformin	0.3	0.5	1.2	0.0	-0.8	-0.6	-0.6	-1.1	-0.7	-0.3	0.5	1.1	-0.4
Diabetes (father)	1.3	1.6	4.2	-0.8	-1.4	-1.5	-1.4	0.5	-1.4	1.3	2.0	0.7	-0.5
Diabetes (mother)	1.3	1.6	3.1	-1.4	-1.5	-1.5	-1.5	1.4	-1.5	0.8	0.2	-1.8	-0.6
Severe depression (siblings)	0.3	0.3	1.1	-0.7	-0.6	-0.1	-0.2	-0.5	-0.5	0.5	-1.1	-0.6	0.4
Pack years adult smoking proportion	0.9	1.4	4.8	-0.1	-1.1	-0.9	-0.8	-1.1	-1.2	-0.2	2.0	2.2	-0.4
Impedance of leg (right)	2.0	9.5	23.6	2.5	4.9	3.6	3.6	0.7	4.8	1.1	1.9	1.1	3.1
Leg fat-free mass (left)	0.5	2.5	7.5	-0.9	-2.4	-1.6	-1.6	-1.6	-2.7	-1.0	-0.2	1.1	-1.1
Trunk fat percentage	0.9	3.8	8.8	-1.7	-2.5	-2.3	-2.3	1.5	-3.0	1.6	1.3	0.4	-1.7
Hand grip strength (right)	0.1	0.3	1.5	0.2	-0.1	-0.0	-0.1	-0.6	0.6	0.5	0.7	1.2	0.3
Townsend deprivation index at recruitment	0.7	1.0	1.7	-0.8	-1.3	-1.2	-1.2	0.6	-1.2	0.2	-0.7	-0.5	-1.2
Current tobacco smoking	1.3	2.1	4.5	-0.7	-2.1	-1.7	-1.7	0.1	-1.8	0.1	1.2	1.9	-1.2
Average weekly fortified wine intake	0.3	0.3	1.5	0.2	0.4	0.4	0.4	0.2	-0.2	-0.1	1.1	1.2	0.0
Maternal smoking around birth	2.1	3.1	5.2	2.1	1.8	2.3	2.3	-1.2	2.0	-1.4	-1.4	0.8	1.6
Fed-up feelings	5.1	9.2	21.3	2.7	4.6	3.7	3.7	-0.8	4.6	0.2	-1.7	0.8	3.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.9	0.3	1.5	1.4	1.4	-0.6	2.2	0.7	-1.1	-0.1	1.3
Relative age voice broke	0.6	1.0	2.3	0.9	1.0	1.0	1.0	-0.7	1.5	-1.4	-0.0	0.5	0.9
Taking other prescription medications	0.3	0.4	2.0	1.0	0.3	0.5	0.5	-0.4	0.5	0.0	-0.5	1.4	0.1
Age when periods started (menarche)	1.7	4.1	5.9	2.0	2.4	2.4	2.4	-1.0	2.4	-2.3	-2.3	0.3	1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.0	-0.5	-0.7	-0.8	-0.8	0.2	-1.1	0.5	2.0	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	5.8	13.1	31.7	-3.5	-5.6	-4.5	-4.5	0.3	-4.9	0.2	2.2	0.7	-4.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.5	-1.6	-1.3	-1.4	-1.4	0.8	-0.5	1.1	-0.5	-1.1	-1.1
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.0	-0.1	-0.3	-0.2	-0.3	0.3	0.0	0.6	0.7	-0.3
Serious illness, injury or assault to yourself	2.2	2.6	4.7	1.6	2.1	2.1	2.1	-1.1	1.6	-0.6	0.2	1.4	2.2
High blood pressure	1.8	5.0	13.5	-1.5	-3.6	-2.7	-2.7	-0.6	-3.7	1.1	1.1	0.3	-2.1
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.2	1.2	1.4	1.6	1.6	-2.3	1.1	-1.2	-1.0	0.9	1.4
Multivitamins +/- minerals	0.8	1.0	5.7	-0.6	-0.5	-0.1	-0.2	1.0	-0.6	-0.8	-2.4	-0.7	-1.0
Stomach or abdominal pain in last month	5.3	6.6	11.6	2.4	3.3	3.1	3.1	-1.3	3.4	-0.7	0.9	2.7	2.8
Supplements: Glucosamine	0.8	1.1	3.1	1.4	1.0	1.1	1.0	-1.0	0.6	-0.2	0.4	1.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.9	0.6	0.6	0.7	-0.4	0.2	-0.3	-0.8	0.2	0.6
Medication: Atenolol	3.0	3.7	8.0	-1.9	-2.5	-2.3	-2.3	1.4	-2.8	0.6	0.1	-1.0	-2.4
Medication: Levothyroxine sodium	1.3	2.2	6.2	1.3	2.5	1.5	1.5	1.5	1.7	1.7	0.6	-0.1	1.1
Sitting height	0.6	4.2	13.6	2.0	0.8	1.4	1.4	-3.7	-0.5	-3.4	0.1	2.7	0.7
Chronic bronchitis/emphysema (father)	2.1	2.5	5.4	-1.6	-1.6	-1.6	-1.7	1.6	-1.5	1.2	-0.3	-2.3	-1.7
High blood pressure (mother)	1.5	2.1	6.9	-0.9	-1.4	-1.6	-1.6	0.4	-2.6	0.7	1.6	-1.3	-1.4
Body mass index (BMI)	2.8	12.1	28.1	-3.3	-5.3	-4.5	-4.5	0.9	-5.1	1.5	1.0	0.1	-3.3
Impedance of leg (left)	2.3	10.9	26.7	2.8	5.2	4.0	4.0	0.7	5.1	0.7	1.6	1.2	3.4
Leg predicted mass (left)	0.5	2.4	7.0	-0.7	-2.3	-1.5	-1.5	-1.7	-2.6	-1.1	-0.2	1.2	-1.0
Trunk fat mass	0.8	3.4	9.1	-1.5	-2.6	-2.2	-2.2	0.7	-3.0	1.0	1.3	1.0	-1.6
Waist circumference	0.6	2.0	5.5	-1.4	-2.0	-1.8	-1.7	0.5	-2.3	0.4	0.4	0.6	-1.3
Number of incorrect matches in round	0.6	1.1	2.3	1.1	0.9	1.1	1.1	-1.5	0.8	-0.7	0.6	0.9	1.1
Past tobacco smoking	0.5	0.9	2.4	0.4	1.6	0.9	0.9	-0.8	0.7	-0.5	-1.2	-1.5	0.2
Alcohol usually taken with meals	0.6	1.0	2.2	-0.5	-1.3	-0.9	-0.9	0.3	-1.5	-1.1	0.6	-0.3	-1.5
Nervous feelings	7.8	14.6	34.0	3.7	5.8	4.8	4.9	-0.8	5.5	-0.4	-0.8	2.1	4.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	6.3	0.6	2.5	1.7	1.8	0.1	2.5	0.9	-1.2	-0.9	1.7
Hearing difficulty/problems with background noise	0.9	1.4	2.5	1.2	1.5	1.5	1.6	-0.5	1.4	0.6	0.0	1.2	1.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	-0.4	-0.8	-0.7	-0.7	1.3	-0.4	-0.4	-1.0	-0.1	-0.9
Had menopause	3.5	4.4	8.1	-2.1	-2.7	-2.6	-2.5	1.9	-2.9	0.5	0.8	-1.4	-2.0
Had other major operations	1.1	1.4	4.1	0.7	0.7	1.2	1.2	-1.7	0.4	-2.0	-1.2	0.7	1.0
Forced vital capacity (FVC)	2.7	10.2	18.2	3.2	4.2	4.0	4.0	-2.6	4.3	-2.1	-1.9	1.4	2.9
Heel bone mineral density (BMD) T-score, automated (right)	5.0	11.4	27.2	-3.0	-5.2	-4.3	-4.3	-0.2	-4.7	0.5	2.2	1.3	-3.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.5	0.6	0.9	1.1	1.1	-0.6	0.7	-0.4	-1.6	-0.3	0.8
Qualifications: None of the above	0.3	0.6	1.2	-1.1	-0.7	-0.7	-0.7	0.9	-0.8	0.9	-0.4	-0.5	-0.7
Financial difficulties in last 2 years	0.6	0.7	1.5	0.1	0.4	0.7	0.7	-1.0	1.2	-1.1	0.3	1.2	1.0
Mouth/teeth dental problems	1.1	1.6	3.9	0.9	2.0	1.7	1.7	0.3	1.6	-0.4	-1.5	-0.6	0.9
Heart attack	0.6	0.7	2.8	-0.6	-0.2	-0.3	-0.3	1.5	-0.5	1.7	0.8	0.8	-0.3
Allergy	0.1	0.3	0.8	0.0	0.4	-0.0	-0.1	0.9	0.7	0.9	0.9	-0.3	-0.3
Pain all over the body in last month	0.9	0.9	2.7	-0.2	-1.1	-1.0	-1.0	-0.9	-0.9	0.5	1.6	1.2	-0.2
Diabetes (self-reported)	0.3	0.4	1.5	-0.3	-0.6	-0.7	-0.7	-0.2	-0.3	1.1	1.2	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.9	0.9	1.5	1.4	1.4	0.3	0.6	-0.6	-2.0	-0.8	0.8
Medication: Ramipril	0.5	0.7	2.3	0.3	-0.8	-0.3	-0.3	-1.2	-0.8	-0.3	1.2	1.5	0.1
Medication: Simvastatin	0.4	0.6	2.4	-0.5	-0.6	-0.8	-0.8	-0.1	-0.3	0.8	1.5	0.5	-0.8
Fluid intelligence score	0.7	1.6	9.9	0.9	0.8	0.5	0.5	-0.4	0.1	1.4	3.1	1.1	0.5
Illnesses of siblings	0.1	0.2	0.5	-0.2	0.6	0.2	0.2	0.5	0.3	0.0	-0.7	-0.5	-0.4
Neuroticism score	12.2	25.5	56.2	5.0	7.5	6.4	6.4	-2.0	7.0	-0.6	-1.1	2.5	5.6
Weight	0.5	2.6	7.5	-1.2	-2.4	-1.8	-1.8	-0.7	-2.7	0.0	0.8	1.4	-1.2
Impedance of arm (right)	1.8	8.5	23.0	2.9	4.8	3.8	3.8	0.3	3.8	-0.8	-0.4	0.4	2.8
Arm fat percentage (right)	1.9	7.5	16.0	-2.5	-3.9	-3.4	-3.4	1.3	-4.0	1.6	1.5	0.7	-2.6
Trunk fat-free mass	0.3	1.5	6.2	0.3	-0.6	0.0	0.1	-2.5	-0.6	-1.9	0.0	2.0	0.3
Hip circumference	0.5	2.1	6.4	-0.9	-2.0	-1.5	-1.4	-0.5	-2.5	-0.1	1.3	1.8	-0.8
Time employed in main current job	1.4	1.6	7.3	-1.5	-0.6	-0.9	-0.9	2.7	-0.3	1.4	0.8	-0.7	-1.3
Alcohol intake versus 10 years previously	2.0	3.0	5.1	1.9	1.7	1.8	1.8	-1.8	2.2	-0.2	0.1	2.3	2.0
Father’s age at death	3.3	4.4	9.9	2.2	3.1	2.9	2.9	-0.9	2.6	-0.7	-1.0	0.4	1.8
Worrier / anxious feelings	11.9	22.5	46.2	4.8	6.8	5.9	6.0	-1.3	6.3	-1.0	-0.2	2.3	6.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.5	-0.1	1.2	0.6	0.6	0.2	1.1	1.2	-0.1	-0.0	0.6
Falls in the last year	0.5	0.7	2.5	0.7	0.6	0.8	0.8	-1.6	0.6	-0.1	-0.6	1.0	0.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.7	0.0	-0.0	0.0	0.0	-0.8	0.3	0.1	0.6	0.2	0.3
Number of live births	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.2	-0.1	-0.3	0.1	0.0	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1)	4.1	13.9	28.7	3.6	5.1	4.7	4.7	-2.4	5.4	-1.4	-1.2	1.8	3.8
Pulse rate	0.2	0.3	0.6	0.6	0.7	0.7	0.8	0.1	0.0	-0.4	0.2	0.4	0.4
Happiness	0.3	0.4	1.7	0.4	-0.1	0.0	0.1	-1.1	0.3	-0.1	0.9	1.3	0.2
Noisy workplace	0.7	0.9	5.3	-0.4	0.1	0.1	0.0	0.7	1.1	0.7	-2.3	-1.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.9	0.8	1.3	1.0	1.0	-0.0	0.1	-2.0	-0.9	-1.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	6.1	0.6	0.7	0.7	0.7	0.8	0.5	-1.0	-2.5	-1.2	0.1
Mouth/teeth dental problems: Dentures	5.1	8.7	15.1	-2.8	-3.9	-3.7	-3.7	2.3	-3.9	1.9	2.0	-0.5	-2.8
Asthma	0.3	0.5	2.6	-0.1	-1.0	-0.7	-0.6	0.0	-1.6	-0.9	-0.0	-0.2	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.2	1.3	1.7	1.6	1.6	-1.2	1.3	-0.7	0.2	0.6	1.8
Medication: Cholesterol lowering	0.4	0.7	3.8	0.3	0.1	0.1	0.1	0.1	0.2	1.2	2.0	1.1	0.3
Depression (self-reported)	0.5	0.6	2.5	0.2	0.9	0.8	0.8	1.0	0.8	0.1	-1.6	-0.0	0.3
Medication: Lansoprazole	0.7	0.8	5.3	0.6	0.3	-0.1	-0.1	-0.1	-0.6	0.4	2.3	1.3	0.3
Prospective memory result	0.9	1.2	2.6	1.0	0.9	1.2	1.1	-0.8	1.0	-1.6	0.1	1.0	1.2
Lung cancer (father)	1.0	1.2	1.7	-1.2	-1.0	-1.3	-1.2	1.3	-1.3	0.9	0.8	-0.3	-1.2
Illnesses of mother	1.2	1.4	5.6	0.6	0.2	0.8	0.8	-1.2	0.4	-2.4	-1.8	1.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.0	25.7	3.4	4.6	4.3	4.2	-2.7	5.1	-1.0	-1.1	1.8	3.6
Pulse wave Arterial Stiffness index	2.0	2.4	3.7	-1.6	-1.9	-1.9	-1.9	0.8	-1.7	1.7	1.3	-0.0	-1.5
Impedance of arm (left)	1.7	7.9	21.2	3.0	4.6	3.7	3.7	0.2	3.5	-1.0	-0.2	0.4	2.7
Arm fat mass (right)	1.8	7.2	17.5	-2.4	-4.0	-3.4	-3.4	0.7	-4.2	0.9	1.1	0.6	-2.5
Trunk predicted mass	0.3	1.5	5.8	0.3	-0.7	-0.0	0.0	-2.4	-0.7	-1.8	0.2	2.1	0.2
Standing height	1.6	15.7	28.5	4.1	5.3	5.1	5.1	-3.3	4.3	-3.0	-0.4	2.7	3.9
Length of working week for main job	0.8	0.9	3.4	-0.7	-0.3	-0.5	-0.5	-0.8	-0.1	1.1	1.8	1.5	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.0	-0.3	-0.3	-0.3	-0.4	-0.3	-0.4	-0.1	-0.1	-0.4
Breastfed as a baby	0.3	0.3	0.7	0.3	0.6	0.6	0.6	-0.0	0.8	-0.6	0.3	-0.6	0.6
Tense / ‘highly strung’	2.9	4.7	13.1	1.2	3.2	2.5	2.4	0.5	3.6	2.6	-0.9	0.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	7.7	1.8	2.8	2.2	2.2	-0.9	2.6	0.2	0.4	1.5	2.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.4	-0.6	0.4	0.1	0.1	0.4	-0.4	0.3	1.2	-0.6	0.2
Birth weight of first child	0.1	0.2	0.5	-0.5	0.2	-0.3	-0.3	0.5	0.2	0.7	0.5	-0.5	-0.1
Peak expiratory flow (PEF)	7.1	16.4	33.5	3.9	5.5	5.2	5.2	-1.9	5.8	-1.1	-0.8	2.1	4.6
Pulse wave reflection index	1.6	2.0	3.1	-1.4	-1.7	-1.8	-1.7	0.2	-1.4	1.7	1.4	-0.3	-1.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.3	1.0	0.6	0.6	0.7	0.2	0.5	-0.7	-0.8	0.4
Loud music exposure frequency	0.9	1.0	3.5	-0.5	-0.8	-0.2	-0.2	0.5	-0.7	-1.2	-1.9	-1.8	-0.4
Qualifications: O levels/GCSEs or equivalent	2.7	4.4	8.3	2.5	2.9	2.8	2.8	-1.0	2.1	-1.8	-1.0	1.1	1.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	-0.8	-1.4	-1.1	-1.1	-0.7	-0.1	0.4	-0.7	-0.4	-0.8
Blood clot in the leg (DVT)	6.1	7.9	13.1	-3.1	-3.4	-3.5	-3.5	1.8	-3.6	1.4	0.6	-2.0	-3.2
Medication: Paracetamol	1.4	2.3	4.8	1.3	2.0	1.3	1.4	-1.3	2.2	1.0	0.4	1.2	2.0
Headache pain in last month	3.1	5.4	13.0	2.1	3.5	2.6	2.6	-1.2	3.6	0.2	0.0	0.3	3.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.6	-0.4	0.4	0.1	0.1	1.2	0.8	0.2	-1.3	-1.6	0.0
Glaucoma (self-reported)	1.4	1.7	6.7	1.4	0.9	0.9	1.0	-1.2	1.0	-0.4	1.4	2.6	1.1
Gout (self-reported)	0.4	0.6	2.3	-0.6	-0.3	-0.3	-0.4	0.1	0.0	1.5	1.5	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	8.8	1.6	3.0	1.9	1.9	1.4	1.9	1.1	-0.3	-0.6	1.1
Medication: Amlodipine	0.4	0.6	1.5	-0.4	-1.0	-0.6	-0.6	-0.8	-0.5	-0.6	-1.0	1.2	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.5	-0.1	0.3	0.3	-0.4	0.0	-0.5	-0.1	0.4	0.5
Birth weight	1.4	3.0	5.2	-2.3	-2.3	-2.1	-2.1	1.5	-1.7	0.8	1.1	-0.9	-1.6
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.0	-0.8	-0.4	-0.5	-0.5	0.8	0.5	1.0	-0.6	-0.9	-0.9
High blood pressure (siblings)	0.1	0.1	0.3	-0.1	-0.6	-0.4	-0.4	-0.2	0.1	0.2	0.4	0.4	0.4
Forced vital capacity (FVC), Best measure	1.9	7.1	14.5	2.5	3.3	3.2	3.1	-2.7	3.8	-1.0	-1.6	1.1	2.7
Body fat percentage	1.5	5.7	11.4	-2.1	-3.1	-2.9	-2.9	1.6	-3.4	2.0	1.9	0.6	-2.1
Leg fat percentage (right)	2.3	8.3	15.4	-2.7	-3.9	-3.6	-3.6	1.7	-3.5	2.7	2.4	0.7	-2.4
Arm fat-free mass (right)	0.3	1.3	3.1	-0.5	-1.7	-1.0	-1.0	-1.5	-1.8	-0.8	0.3	1.4	-0.4
Exposure to tobacco smoke outside home	0.3	0.4	1.0	1.0	0.7	0.7	0.7	-0.2	0.7	-0.6	-0.7	0.3	0.3
Comparative body size at age 10	6.2	17.1	30.9	-4.3	-5.6	-5.5	-5.5	1.9	-5.2	2.8	1.6	-1.8	-4.2
Number of full brothers	0.4	0.6	1.1	-0.4	-0.9	-0.5	-0.6	-1.0	-0.1	-0.9	-1.0	-0.8	-0.7
Worry too long after embarrassment	6.2	10.4	21.5	2.9	4.6	4.4	4.3	-0.9	4.5	0.3	-1.2	1.1	3.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	1.0	1.0	0.9	0.9	-1.1	0.9	-0.6	0.1	0.8	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	3.5	-0.4	-1.6	-1.1	-1.1	-0.8	-1.9	0.5	1.0	1.2	-0.3
Number of children fathered	1.7	1.9	6.5	1.3	0.4	1.0	1.0	-0.8	-0.4	-1.7	1.8	2.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.7	1.3	1.2	1.6	1.6	0.0	0.4	-1.4	0.4	0.9	1.2
Age at first live birth	1.4	2.4	4.6	1.0	2.1	1.9	1.9	-0.4	1.8	-1.4	-2.1	-0.8	1.0
Pulse wave peak to peak time	2.5	3.0	4.6	1.8	2.1	2.1	2.1	-0.8	1.9	-1.9	-1.5	-0.0	1.7
Health satisfaction	0.8	1.0	3.6	-0.7	-1.4	-1.1	-1.1	0.1	-1.9	-0.2	-0.7	-0.7	-0.8
Shortness of breath walking on level ground	2.1	2.5	4.1	-2.0	-1.9	-1.5	-1.5	1.5	-2.0	1.1	-1.2	-1.4	-1.5
Qualifications: College or University degree	0.2	0.5	1.8	0.1	0.1	0.0	0.0	-0.4	-0.5	-1.2	-1.2	-1.4	-0.2
Eye problems/disorders: None of the above	2.7	3.1	9.0	1.4	1.6	1.9	1.9	-0.6	1.8	-1.6	-3.0	-1.3	1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.6	-1.4	-1.6	-1.2	-1.2	-1.1	-0.5	0.9	1.0	0.9	-0.6
Emphysema/chronic bronchitis	3.2	3.6	7.3	-1.9	-2.7	-2.5	-2.5	0.1	-2.3	1.0	1.9	0.3	-1.8
Medication for pain relief, constipation, heartburn	1.2	2.0	3.9	-1.0	-1.5	-1.1	-1.1	1.3	-1.3	-1.5	-2.0	-1.6	-1.6
Neck or shoulder pain in last month	0.2	0.3	1.0	0.7	1.0	0.4	0.5	-0.0	0.6	0.8	-0.3	-0.4	0.3
Medication: Blood pressure	0.6	1.1	3.0	0.1	-1.2	-0.9	-0.8	-1.5	-1.7	-0.5	0.8	1.3	-0.7
Angina (self-reported)	0.9	1.2	3.1	-1.1	-1.3	-1.1	-1.1	1.2	-1.8	0.9	-0.1	-0.3	-1.0
Migraine (self-reported)	0.6	0.8	2.7	0.4	1.0	0.5	0.5	-0.3	1.2	0.7	1.6	0.4	1.0
Medication: Ibuprofen	0.7	0.9	2.0	0.7	1.3	1.2	1.1	-0.4	0.8	-0.0	0.8	0.5	1.4
Medication: Allopurinol	0.7	0.9	2.6	-1.1	-0.8	-0.8	-0.9	0.7	-0.6	1.5	1.6	0.3	-0.2
Medication: Omeprazole	0.9	1.0	3.5	0.8	0.8	0.9	0.9	-1.6	0.6	-0.3	0.1	1.9	1.0
Medication: Seretide 50 evohaler	0.3	0.4	1.8	0.3	0.0	0.1	0.1	-1.3	-0.4	-0.8	-0.9	-0.3	0.3
Mean time to correctly identify matches	0.2	0.5	0.7	0.7	0.4	0.8	0.8	-0.8	0.7	0.6	-0.9	0.1	0.5
Heart disease (mother)	0.1	0.1	0.4	0.0	0.5	0.1	0.1	0.3	0.3	0.4	0.2	-0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.6	0.0	1.0	0.7	0.7	1.6	0.6	0.1	-0.0	-0.9	1.0
Whole body fat mass	1.3	5.4	12.5	-2.1	-3.3	-2.9	-2.9	0.9	-3.5	1.1	1.3	0.6	-2.1
Leg fat mass (right)	2.2	8.5	17.5	-2.8	-4.2	-3.7	-3.7	1.2	-4.1	1.9	1.9	0.6	-2.6
Arm predicted mass (right)	0.3	1.4	3.0	-0.5	-1.7	-1.0	-1.0	-1.6	-1.6	-0.6	0.6	1.5	-0.4
Pulse rate, automated reading	0.2	0.8	3.9	0.5	0.2	0.1	0.1	0.3	0.0	0.1	2.0	1.8	0.5
Alcohol intake frequency.	0.7	1.6	3.2	1.5	1.6	1.3	1.4	-0.6	0.9	-0.6	-0.5	1.8	1.7
Comparative height size at age 10	0.4	2.0	5.7	1.2	1.1	1.2	1.2	-2.1	0.8	-0.7	1.4	2.4	1.1
Number of full sisters	2.0	2.5	4.9	-1.9	-2.1	-2.0	-2.0	1.3	-2.2	0.6	-0.1	0.1	-1.5
Suffer from ‘nerves’	6.3	9.9	21.3	3.1	4.4	4.0	3.9	-1.1	4.6	1.5	-0.2	2.2	3.1
Overall health rating	2.0	4.3	10.3	-2.2	-3.2	-2.6	-2.6	0.7	-3.0	1.0	0.7	0.6	-1.8
Chest pain or discomfort	0.1	0.1	1.0	0.1	-0.1	0.0	0.0	-0.3	-0.2	0.1	0.5	1.0	0.0
Had major operations	0.8	0.9	1.3	1.0	1.1	1.0	1.0	0.0	0.5	1.0	1.1	1.0	1.1
Age at last live birth	3.6	5.3	10.7	2.1	3.3	3.1	3.1	-1.0	2.9	-1.1	-1.1	0.8	2.4
Family relationship satisfaction	0.6	0.8	1.4	-0.8	-1.0	-0.8	-0.8	1.0	-0.7	0.6	-1.2	-1.0	-0.8
Leg pain on walking	0.1	0.2	0.4	0.2	0.0	0.5	0.5	-0.5	0.2	-0.4	-0.3	0.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.4	1.2	1.2	1.2	1.1	-1.1	1.1	-0.6	1.3	1.8	1.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	-0.5	-0.6	-0.7	-0.7	0.2	-0.2	1.1	-0.4	-0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.5	0.5	-0.2	-0.2	-0.2	-1.1	-0.1	1.2	2.1	1.0	-0.0
Medication: Aspirin	3.9	5.1	13.9	-1.7	-2.2	-2.5	-2.4	0.6	-2.4	3.1	3.7	0.0	-1.4
Supplements: Vitamin C	0.9	1.0	2.0	-0.6	-1.4	-1.1	-1.1	-1.0	-1.0	-0.5	0.4	1.1	-1.3
Knee pain experienced in last month	0.1	0.1	0.6	0.1	-0.2	-0.1	-0.1	-0.8	-0.2	0.1	0.1	0.2	-0.4
Hypertension (Self-reported)	1.9	5.4	14.4	-1.6	-3.6	-2.8	-2.8	-0.4	-3.8	1.2	1.4	0.3	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.5	1.1	1.0	1.5	1.5	-1.5	1.3	-1.9	-0.7	1.3	1.0
Illnesses of father: Heart disease	0.3	0.4	1.2	-0.3	0.2	0.4	0.4	0.9	-0.2	0.0	-1.1	-1.1	0.7
Illnesses of siblings: Diabetes	1.9	2.3	4.4	-1.6	-2.1	-1.9	-1.9	1.0	-1.9	0.6	-0.1	-1.5	-1.4
Smoking status: Previous	0.4	0.7	1.9	-0.5	-1.4	-0.9	-0.9	1.0	-0.9	0.3	0.6	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.1	11.7	2.8	3.4	3.1	3.1	-1.9	2.9	-1.3	1.1	2.8	3.1
Whole body fat-free mass	0.3	1.5	4.8	-0.1	-1.3	-0.6	-0.6	-2.2	-1.5	-1.5	-0.1	1.8	-0.2
Leg fat-free mass (right)	0.4	2.1	6.0	-0.6	-2.0	-1.2	-1.2	-1.8	-2.4	-1.4	-0.6	1.1	-0.9
Arm fat percentage (left)	2.0	8.0	18.0	-2.5	-4.0	-3.5	-3.5	1.3	-4.2	1.6	1.4	0.4	-2.7
Average weekly red wine intake	1.5	2.2	8.0	-1.3	-2.0	-1.5	-1.6	1.0	-2.8	0.0	0.9	-0.3	-1.1
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.2	-0.3	0.2	0.0	0.0	-0.5	-0.0	-0.1	0.3	-0.3	0.1
Mood swings	4.5	8.1	19.0	2.7	4.4	3.5	3.5	-1.1	3.7	-0.9	-1.1	1.5	3.2
Loneliness, isolation	0.2	0.3	1.3	-0.4	0.5	0.1	0.2	-0.0	0.7	0.7	-1.1	-0.9	0.0
Long-standing illness, disability or infirmity	0.6	0.9	2.8	1.1	0.9	1.1	1.1	-0.6	0.3	-0.2	-0.1	1.7	1.0
Ever had bowel cancer screening	3.6	4.2	6.6	2.2	2.4	2.5	2.5	-1.4	2.1	-0.9	0.4	2.4	2.6
Diabetes diagnosed by doctor	0.4	0.7	2.0	-0.6	-0.9	-0.9	-0.9	-0.2	-0.4	1.1	1.4	0.7	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	-0.2	-0.9	-0.6	-0.6	-0.6	-0.8	-0.1	1.0	0.9	-0.7
Friendships satisfaction	0.9	1.2	2.0	-1.3	-1.1	-1.0	-1.0	1.0	-0.0	1.2	-1.4	-1.2	-0.9
Qualifications: nursing, teaching	0.6	0.9	1.8	1.4	0.9	1.2	1.2	-0.2	0.7	-1.3	-0.0	1.0	1.0
Commuting to job workplace: Walk	0.4	0.5	1.8	0.1	0.3	0.0	0.1	0.7	-0.2	-1.0	-1.3	-1.1	-0.2
Eye problems/disorders: Cataract	1.5	1.7	4.0	-1.3	-1.0	-1.4	-1.4	1.0	-1.8	1.1	2.0	0.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	2.6	4.2	7.6	2.8	2.6	2.4	2.4	-1.8	2.2	-1.0	0.3	1.2	2.3
Medication for cholesterol	2.2	3.3	7.3	1.7	2.7	2.2	2.3	-0.4	2.3	-1.3	-1.3	-0.3	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.6	1.2	1.5	1.7	1.8	-1.4	1.9	-0.7	-1.2	1.2	1.4
Back pain experienced in last month	6.5	9.4	17.0	4.1	3.0	3.0	3.0	-2.9	3.1	-1.3	1.7	4.0	3.5
Mineral and other dietary supplements	1.1	1.5	3.7	1.2	1.9	1.4	1.5	-0.6	1.9	-0.1	-0.2	-0.1	1.3
Breast cancer (self-reported)	0.5	0.5	1.0	-1.0	-0.9	-0.9	-0.9	0.2	-0.9	-0.7	-0.2	-0.4	-0.8
Asthma (self-reported)	0.3	0.7	3.1	-0.4	-1.3	-0.9	-0.8	0.1	-1.8	-0.6	0.2	-0.1	-0.3
Osteoporosis (self-reported)	0.8	1.0	2.6	0.1	1.1	1.0	1.0	1.1	0.8	0.3	-1.3	-1.6	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.7	-0.3	-0.6	-0.2	-0.3	0.5	-0.1	-1.0	-1.3	0.4	-0.9
Medication: Aspirin	3.8	5.0	12.4	-1.8	-2.1	-2.4	-2.4	0.8	-2.1	3.5	3.3	-0.3	-1.6
Medication: Gliclazide	0.1	0.1	0.3	0.6	-0.2	-0.1	-0.1	-0.4	-0.4	-0.3	0.1	0.4	-0.4
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	0.8	1.0	1.0	0.9	-1.1	1.3	-1.1	0.2	1.4	0.7
Smoking status: Current	0.9	1.5	4.8	-0.4	-1.8	-1.3	-1.3	-0.3	-1.3	-0.2	0.8	2.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.3	1.0	1.4	1.2	1.2	0.5	1.8	0.2	-1.4	-0.7	0.3
Whole body water mass	0.3	1.5	4.6	-0.1	-1.4	-0.6	-0.6	-2.1	-1.6	-1.5	0.0	1.7	-0.3
Leg predicted mass (right)	0.4	2.1	6.3	-0.6	-2.1	-1.2	-1.2	-1.8	-2.5	-1.3	-0.4	1.1	-0.9
Arm fat mass (left)	1.6	6.6	16.3	-2.2	-3.8	-3.3	-3.2	0.6	-4.0	1.0	1.4	0.7	-2.4
Number of self-reported non-cancer illnesses	0.7	1.2	3.1	1.6	1.1	1.3	1.3	-0.7	0.7	-0.7	0.2	1.8	0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-0.7	-1.1	-0.9	-0.9	0.1	-0.7	-0.4	-0.6	-1.2	-1.3
Miserableness	8.0	13.9	29.2	3.1	5.4	4.7	4.7	-1.6	5.1	-1.3	-1.6	1.6	4.5
Guilty feelings	5.5	8.3	17.7	2.9	4.2	3.6	3.6	-1.8	3.9	-0.4	-0.2	1.4	3.2
Wears glasses or contact lenses	0.3	0.3	1.0	0.8	0.4	0.5	0.6	0.6	-0.5	0.2	0.0	-0.2	1.0
Ever taken oral contraceptive pill	1.4	1.6	3.5	0.8	1.4	1.3	1.3	-1.9	1.6	-0.7	1.2	0.6	1.3
Hearing aid user	1.0	1.1	2.5	1.0	1.0	1.1	1.1	-1.6	0.7	-1.3	-0.8	0.5	0.8
Mother’s age at death	1.6	1.9	3.5	1.1	1.9	1.8	1.8	-0.7	1.8	-0.8	-0.8	0.1	1.8
Financial situation satisfaction	0.2	0.3	0.9	0.4	-0.1	0.4	0.4	-0.4	0.3	-0.9	-0.9	0.2	0.0
Tinnitus: Yes, now most or all of the time	1.9	2.3	4.7	1.4	1.6	1.7	1.7	-1.4	1.9	-0.1	0.5	1.3	2.2
Commuting to job workplace: Public transport	0.7	0.8	2.7	0.2	1.0	0.9	0.9	0.6	0.8	-0.8	-1.6	-1.0	0.5
Eye problems/disorders: Glaucoma	0.7	0.8	4.7	0.6	-0.3	-0.2	-0.1	-0.7	0.0	0.1	1.5	2.2	0.1
Medication: Blood pressure	1.6	3.1	8.6	-0.7	-2.9	-1.9	-2.0	-1.0	-2.6	0.2	1.2	1.2	-1.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	2.3	0.1	-0.2	0.0	-0.0	0.1	-0.2	0.2	0.7	1.5	0.1
Supplements: Fish oil (including cod liver oil)	2.0	2.6	6.6	-1.9	-2.6	-1.9	-2.0	1.4	-1.8	0.5	-0.0	-0.0	-1.7
High cholesterol (Self-reported)	0.9	1.5	8.1	-0.5	-0.6	-0.9	-0.9	0.7	-0.1	1.8	2.8	0.9	-0.7
Medication: Bendroflumethiazide	1.5	2.3	7.7	-0.5	-1.6	-1.5	-1.4	-1.1	-1.8	1.0	2.8	1.4	-0.4
Medication: Paracetamol	0.7	1.1	3.5	0.5	1.2	0.5	0.5	-0.5	1.6	1.9	0.7	0.6	1.1
Medication: Lisinopril	0.5	0.6	1.5	-0.5	-1.2	-0.8	-0.8	-0.7	-0.6	0.6	0.4	0.6	-1.2
Medication: Atorvastatin	1.2	1.5	3.8	-1.2	-1.0	-1.1	-1.2	1.7	-1.1	1.9	0.9	-0.4	-1.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.4	-0.3	-0.5	-0.5	-0.1	-0.2	0.6	0.2	-0.2	-0.3
Alcohol drinker status: Never	0.6	0.7	1.5	1.0	1.2	1.1	1.2	0.2	0.6	-0.6	0.1	0.2	1.0
Ever smoked	0.6	1.0	4.7	0.6	-0.2	0.2	0.2	0.4	0.7	0.3	1.7	2.2	1.2
Basal metabolic rate	0.3	1.6	3.7	-0.5	-1.7	-1.0	-1.0	-1.8	-1.9	-1.0	0.3	1.7	-0.5
Leg fat percentage (left)	2.1	7.5	15.0	-2.6	-3.9	-3.4	-3.4	1.6	-3.3	2.3	2.3	0.8	-2.3
Arm fat-free mass (left)	0.3	1.4	4.6	-0.3	-1.3	-0.7	-0.7	-1.8	-1.4	-0.8	0.9	2.1	-0.1
Number of operations (self-reported)	0.6	0.9	2.6	0.8	0.1	0.6	0.6	-1.5	-0.3	-1.4	0.1	1.6	0.4
Average weekly beer plus cider intake	3.0	4.3	14.4	1.6	3.1	2.4	2.4	-0.6	3.8	0.8	-0.3	0.6	1.9
Irritability	12.7	21.6	47.2	4.4	6.9	5.8	5.8	-1.6	6.7	-0.7	-0.8	2.2	5.4
Risk taking	1.7	2.4	7.7	-1.6	-1.7	-1.8	-1.8	-0.1	-1.5	1.3	2.8	0.8	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.3	0.4	0.8	0.8	-0.3	0.9	-0.9	-1.0	0.7	0.4
Fractured/broken bones in last 5 years	0.7	0.9	3.2	-0.5	0.5	0.4	0.4	0.5	0.7	0.8	-1.8	-1.7	0.4
Age started oral contraceptive pill	0.5	0.6	1.5	1.0	1.0	0.8	0.9	-0.1	0.2	-1.2	0.4	0.1	1.1
Diastolic blood pressure, automated reading	4.1	12.8	28.3	-3.7	-5.3	-4.5	-4.6	1.8	-4.9	1.5	0.4	-0.9	-3.7
Ever depressed for a whole week	1.8	2.2	3.7	1.6	1.9	1.9	1.9	-0.5	1.5	-1.1	-1.8	-0.1	1.3
Unable to work because of sickness or disability	0.4	0.5	1.6	-0.2	-0.8	-0.6	-0.6	-0.5	-0.8	0.5	1.1	1.3	-0.3
Commuting to job workplace: Cycle	0.7	0.9	4.8	-0.2	0.2	0.0	0.0	0.1	-0.1	-1.2	-2.2	-1.2	-1.0
Myopia	2.3	3.4	6.3	1.7	2.3	2.3	2.3	-0.6	2.5	-1.3	-0.2	0.9	2.4
Vascular/heart problems diagnosed by doctor	1.8	4.8	13.6	1.4	3.4	2.6	2.6	-0.0	3.7	-1.3	-1.1	-0.3	2.4
Cholesterol lowering medication	0.8	1.1	1.7	-0.9	-1.1	-1.3	-1.3	1.1	-0.6	1.2	1.1	0.1	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.8	0.3	0.7	0.5	0.5	-0.7	0.3	0.5	-0.2	1.3	0.4
Pain experienced in last month	1.5	2.6	3.7	-1.9	-1.7	-1.5	-1.4	1.8	-1.7	-0.4	-1.5	-1.8	-1.7
Supplements: Calcium	0.3	0.4	1.1	-0.8	-0.3	-0.3	-0.4	0.8	-0.5	-0.6	-0.2	-1.1	-0.5
Basal cell carcinoma (self-reported)	1.0	1.1	3.9	0.9	0.5	1.2	1.2	-1.0	0.6	-1.2	-2.0	0.0	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	3.2	-0.4	-0.1	-0.2	-0.2	1.5	-0.3	1.8	0.9	0.9	-0.2
Deep venous thrombosis (DVT) (self-reported)	6.3	8.1	14.1	-3.0	-3.5	-3.6	-3.6	1.8	-3.8	1.2	0.8	-1.8	-3.2
Heart disease (siblings)	0.2	0.2	0.5	-0.5	-0.7	-0.4	-0.5	0.3	-0.5	0.3	0.2	-0.2	-0.7
Alcohol drinker status: Previous	1.8	2.0	4.5	1.3	1.3	1.5	1.5	-2.1	1.5	-0.8	-0.3	1.6	1.4
Pack years of smoking	0.8	1.2	3.6	-0.1	-1.1	-0.8	-0.8	-0.9	-1.2	-0.0	1.6	1.9	-0.5
Impedance of whole body	2.1	10.4	27.9	3.1	5.3	4.1	4.1	0.5	4.6	-0.0	0.6	0.7	3.2
Leg fat mass (left)	2.0	7.8	16.6	-2.7	-4.1	-3.5	-3.5	1.1	-3.9	1.7	1.9	0.7	-2.5
Arm predicted mass (left)	0.3	1.4	3.8	-0.4	-1.5	-0.8	-0.8	-1.8	-1.4	-1.0	0.5	1.9	-0.2