TWAS hub - PCK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1320	0.0350	9.3e-06	0.055	0.061	0.052	0.063	0.062	2.5e-07	5.9e-08	6.0e-07	3.9e-08	5.3e-08
2	GTEx	Nerve Tibial	0.2784	0.0931	2.1e-03	-0.001	NA	0.006	NA	0.010	3.6e-01	NA	1.1e-01	NA	6.3e-02
3	GTEx	Ovary	0.9200	0.0710	3.1e-03	-0.007	NA	0.005	NA	0.007	5.3e-01	NA	2.3e-01	NA	2.1e-01
4	METSIM	Adipose	0.0844	0.0277	6.8e-04	0.004	0.023	0.050	0.020	0.015	7.9e-02	1.9e-04	4.5e-08	4.7e-04	2.4e-03
5	YFS	Blood	0.2222	0.0326	0.0e+00	0.049	0.099	0.122	0.115	0.108	1.2e-15	1.1e-30	7.6e-38	1.1e-35	1.9e-33
6	TCGA	Lung Adenocarcinoma	0.0483	0.0211	1.7e-03	0.012	0.024	0.003	NA	0.011	1.4e-02	6.5e-04	1.2e-01	NA	1.7e-02
7	TCGA	Prostate Adenocarcinoma	0.0451	0.0269	8.9e-03	-0.001	0.003	0.007	NA	0.001	4.1e-01	1.4e-01	6.0e-02	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Tinnitus: Yes, but not now, but have in the past	3.9	4.2	8.6	2.9	-2.1	-0.0	-0.8	2.7	-0.1	2.9
Commuting to job workplace: Public transport	3.9	4.6	9.1	3.0	-3.0	0.3	-0.8	1.9	-1.1	2.9
Medication: Atenolol	3.3	4.1	10.9	-0.6	1.7	0.2	2.4	2.9	3.3	-0.4
Exposure to tobacco smoke at home	2.7	3.0	9.4	-2.3	3.1	-1.5	1.5	-0.0	-0.6	-1.2
Mouth/teeth dental problems: Dentures	2.6	4.4	16.2	-0.6	2.9	-0.4	1.6	1.3	4.0	-1.4
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	10.4	0.4	-2.1	0.0	-1.8	-3.0	-3.2	-0.0
Stomach or abdominal pain in last month	2.3	2.8	7.4	-2.0	1.0	0.9	1.5	-1.6	1.2	-2.7
Falls in the last year	2.3	3.2	7.8	-2.2	1.8	0.2	1.3	-2.8	0.1	-2.1
Back pain experienced in last month	2.3	3.3	8.2	-2.2	0.2	-1.3	2.9	-1.6	0.4	-2.4
Major Depression (MDD)	2.2	2.7	9.2	-2.3	1.8	1.0	0.5	-3.0	0.0	0.0
Severe depression (siblings)	2.1	2.3	8.5	1.1	-1.9	-1.1	-2.9	-0.1	-0.9	1.1
Fluid intelligence score	2.1	4.4	8.2	2.9	-1.7	1.8	-2.5	0.2	-2.1	2.3
Intelligence (Savage-Jansen 2018)	2.0	6.2	13.9	2.7	-2.9	1.1	-3.7	-0.0	-1.5	3.2
Illnesses of mother	2.0	2.5	7.6	0.0	-2.8	0.7	-2.0	-0.2	-2.3	0.2
Commuting to job workplace: Car/motor vehicle	2.0	2.3	5.0	-1.4	2.2	-1.0	0.8	0.5	2.1	-1.8
Taking other prescription medications	1.9	2.9	7.3	-2.3	0.8	-0.2	1.5	-0.4	2.7	-2.0
High blood pressure (mother)	1.9	2.7	7.8	-0.7	2.0	-0.2	2.8	0.6	2.4	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	7.7	1.0	-0.4	-0.9	-1.6	-2.3	-2.8	0.5
Medication: Omeprazole	1.9	2.3	5.4	1.6	-1.6	-1.7	-0.9	1.2	-0.4	2.3
Reaction Time	1.8	3.3	6.8	2.0	-1.1	2.6	-1.4	2.0	-0.9	2.2
Mean Putamen Volume	1.8	2.1	5.3	-2.3	0.7	0.7	1.2	-1.5	0.4	-2.1
Diabetes (father)	1.8	2.2	11.4	-0.4	-0.3	0.7	1.1	1.3	3.4	-0.5
Mouth/teeth dental problems	1.8	2.8	8.5	1.2	-1.7	-0.8	-1.8	-1.4	-2.9	1.0
Qualifications: College or University degree	1.8	5.7	14.9	2.8	-2.6	0.5	-1.7	1.6	-2.2	3.9
Smoking status: Current	1.8	2.8	11.4	-0.7	2.6	-0.0	0.8	-0.5	3.4	-0.7
Medication: Lisinopril	1.8	2.3	7.2	1.9	-0.6	-0.2	0.1	2.7	2.0	0.8
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.5	1.1	-2.3	-1.3	-0.8	0.9	-0.6	2.4
Supplements: Calcium	1.8	1.9	5.7	-1.5	2.4	0.9	0.4	-0.9	0.8	-1.8
Hair/balding pattern: Pattern 3	1.7	2.5	5.5	1.4	-1.9	-0.5	-1.1	1.8	1.4	2.4
Medication: Cholesterol lowering	1.7	2.6	9.2	0.5	2.0	0.4	1.9	3.0	0.5	0.9
Lung cancer (father)	1.7	2.0	6.7	0.0	1.7	2.6	1.2	1.0	0.3	-1.4
Medication: Paracetamol	1.7	2.9	5.9	-2.1	1.7	-0.5	2.4	-1.0	1.6	-1.7
Neck or shoulder pain in last month	1.7	2.4	6.1	-1.9	1.3	-0.5	2.5	-1.6	0.4	-1.5
Medication: Blood pressure	1.7	2.9	10.3	-0.2	1.5	-0.9	1.2	2.3	3.2	0.1
Eye problems/disorders: Cataract	1.7	2.0	8.2	-1.1	0.5	1.2	2.9	0.7	0.4	-1.5
High cholesterol (Self-reported)	1.7	3.1	7.6	0.8	2.3	1.9	0.8	2.8	0.5	1.9
Height	1.6	30.7	77.4	-5.9	5.0	-0.3	3.1	-8.8	-1.2	-8.2
Average weekly spirits intake	1.6	2.0	4.5	2.1	-2.1	-0.1	-1.6	1.3	0.6	0.8
Current tobacco smoking	1.6	2.7	11.2	-0.7	2.3	-0.4	0.7	-0.4	3.3	-0.9
Qualifications: CSEs or equivalent	1.6	2.1	5.4	-1.6	2.3	-0.0	-1.0	-1.8	0.2	-1.7
Heart disease (mother)	1.6	1.9	5.7	1.2	2.4	0.2	1.8	1.3	-0.1	1.0
LDL Cholesterol	1.5	2.4	4.4	1.3	-2.0	1.3	-0.8	2.0	0.8	2.1
Medication: Simvastatin	1.5	2.3	7.7	0.9	1.6	1.0	1.2	2.8	0.6	1.5
Mean time to correctly identify matches	1.5	2.9	8.6	1.8	-1.0	1.3	-0.4	2.9	0.7	2.3
Hearing aid user	1.5	1.7	5.4	-0.9	1.7	0.8	1.0	0.5	2.3	-1.1
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.5	-1.6	1.5	-1.5	1.9	-1.0	-0.0	-1.0
Serious illness, injury or assault to yourself	1.4	1.7	4.6	0.6	1.4	0.1	1.4	2.1	1.5	0.8
Noisy workplace	1.4	1.8	5.6	-0.3	2.4	1.5	1.1	1.3	-0.7	-1.1
Wheeze or whistling in the chest in last year	1.4	2.4	5.3	0.0	1.7	-0.4	2.0	1.8	2.3	-1.3
Had major operations	1.4	1.7	3.4	-1.0	1.8	-0.2	1.8	0.2	1.7	-1.0
Illnesses of father: None of the above (group 1)	1.4	1.7	3.6	-0.9	1.9	-1.6	0.5	-0.4	-1.6	-1.3
Medication: Paracetamol	1.4	2.1	4.3	-1.6	1.7	-0.2	1.7	-0.6	2.1	-1.1
Ever depressed for a whole week	1.4	1.7	7.0	-1.1	1.5	-0.3	-0.2	-2.7	-0.4	-0.9
Alzheimer’s Disease (including proxy)	1.3	1.8	4.9	1.2	-1.8	-0.1	-1.1	0.7	1.2	2.2
Crohns Disease (2017)	1.3	2.9	9.8	-2.0	3.1	0.2	1.2	0.1	0.5	-2.1
Age at First Birth	1.3	1.9	4.8	1.8	0.1	1.7	0.6	0.9	-2.2	0.9
Smoking Status	1.3	3.2	7.4	-2.0	2.6	0.2	-0.0	-1.0	2.7	-1.7
Supplements: Glucosamine	1.3	1.7	4.9	-0.8	1.2	-2.2	1.5	0.5	1.4	-0.7
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	8.6	1.4	0.2	0.9	0.0	2.9	0.2	0.6
Standing height	1.3	12.5	41.6	-4.0	1.9	0.3	2.2	-6.5	-0.2	-4.6
Overall health rating	1.3	2.9	5.4	-1.9	2.3	1.9	1.8	-0.6	-0.6	-1.8
Illnesses of siblings: Diabetes	1.3	1.7	8.4	-0.1	0.2	-1.7	2.9	0.5	0.2	-0.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	6.7	-1.2	0.3	-2.6	-0.7	-1.3	-0.3	-1.1
Illnesses of father: High blood pressure	1.3	1.6	3.4	1.1	-1.4	-0.4	-1.3	1.2	0.9	1.9
Fasting Glucose	1.2	1.5	3.3	0.6	-0.5	1.8	-1.5	-0.5	-1.0	1.7
Hearing difficulty/problems: Yes	1.2	1.8	5.3	-1.8	0.3	-0.0	2.3	-0.3	0.3	-1.9
Qualifications: None of the above	1.2	2.6	8.4	-1.2	1.9	-0.6	0.5	-0.1	2.9	-2.1
Pain all over the body in last month	1.2	1.2	3.8	-0.8	1.1	-1.4	-0.9	-2.0	0.5	-0.5
Illnesses of siblings	1.2	1.6	7.6	0.2	-1.8	0.5	-2.8	-0.7	0.0	0.2
Number of operations (self-reported)	1.2	1.8	3.9	-1.6	1.8	-0.1	1.4	-0.1	2.0	-0.8
HbA1C	1.1	1.2	4.3	0.3	0.5	-0.1	-2.1	-0.9	-1.5	0.9
Multivitamins +/- minerals	1.1	1.5	4.4	-0.5	2.1	-0.8	-1.0	0.0	2.0	-0.2
Past tobacco smoking	1.1	2.1	4.3	2.0	-1.8	0.6	-0.7	0.4	-2.1	1.4
Alcohol intake versus 10 years previously	1.1	1.7	3.1	-1.5	0.7	-1.7	1.7	-0.7	-0.7	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.5	-0.8	0.9	0.8	1.2	2.3	0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.6	-0.4	1.2	1.0	1.3	-0.1	0.4	-2.1
Number of self-reported non-cancer illnesses	1.1	1.8	4.9	1.4	0.3	2.2	-1.3	1.6	1.1	0.7
Mother’s age at death	1.1	1.4	4.3	1.5	-0.6	1.4	0.9	0.6	-0.1	2.1
Pack years of smoking	1.1	1.6	3.6	-0.1	1.9	-0.3	1.7	-1.0	1.5	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.4	5.2	1.5	-0.8	-0.4	-1.2	2.3	0.0	0.0
Irritable Bowel Disease (IBD)	1.0	2.5	12.8	-1.1	3.6	-0.0	1.3	0.0	0.6	-1.1
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.9	2.4	-1.3	1.6	-2.0	-0.2	-1.0	1.6
Number of treatments/medications taken	1.0	1.7	4.7	-1.4	1.9	0.1	0.7	0.7	2.2	-0.8
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.5	-1.0	0.0	-1.4	1.3	0.1	1.9	-0.6
Sitting height	1.0	7.4	20.6	-3.3	1.9	0.7	1.4	-4.5	-0.5	-3.8
Alcohol usually taken with meals	1.0	1.7	5.7	1.2	-2.4	0.4	-0.3	0.9	0.6	1.8
Pulse rate	1.0	1.7	3.6	1.9	-0.5	0.4	-1.8	-0.7	-1.7	1.1
Medication: Ventolin 100micrograms inhaler	1.0	1.2	5.5	-1.0	2.3	0.9	0.4	0.0	1.0	-0.7
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.7	1.1	-0.7	0.6	-1.5	0.5	-1.6	1.0
Pulse rate, automated reading	1.0	3.3	6.3	2.5	-1.5	1.8	-0.7	-0.9	-2.5	2.1
Smoking status: Previous	1.0	1.5	4.2	-2.1	0.5	-0.5	0.8	-0.3	1.4	-1.8
Ever had bowel cancer screening	1.0	1.2	3.3	0.5	-1.5	-1.8	-1.4	0.7	-0.2	0.5
Mineral and other dietary supplements	1.0	1.4	5.4	0.6	-0.7	2.3	0.4	-0.0	-1.2	1.3
Ever smoked	1.0	1.8	4.3	-1.9	2.1	-0.8	0.0	-0.7	1.5	-1.0
Alzheimer’s Disease (in father)	0.9	1.0	3.9	0.6	-2.0	-0.4	-1.1	-0.2	1.0	0.7
Crohns Disease (2012)	0.9	1.4	3.1	-1.7	1.8	1.0	0.2	-0.7	-0.4	-1.6
Waist Hip Ratio (WHR)	0.9	4.2	11.4	-3.4	1.4	0.5	2.6	-1.2	0.6	-2.7
Pack years adult smoking proportion	0.9	1.4	3.3	-0.2	1.8	-0.1	1.5	-1.3	0.9	-1.4
Townsend deprivation index at recruitment	0.9	1.2	4.1	-0.9	0.7	-0.2	0.5	-2.0	1.1	-1.2
Waist circumference	0.9	3.5	8.1	-1.6	2.9	0.4	2.3	-1.2	1.9	-1.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.0	-1.3	0.8	0.6	1.4	-1.2	-0.8	-1.1
Number of full brothers	0.9	1.2	2.9	-0.1	1.7	0.7	0.1	1.6	0.9	1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.2	0.8	0.1	1.8	-0.1	1.5	0.7	1.1
Emphysema/chronic bronchitis	0.9	1.0	2.4	-1.3	0.5	-0.7	0.6	-0.8	1.1	-1.6
Medication: Allopurinol	0.9	1.2	4.3	0.0	1.6	-0.3	0.8	0.8	2.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.8	-0.4	1.0	1.9	1.1	-1.6	0.2	-2.2
Long-standing illness, disability or infirmity	0.9	1.3	2.8	-1.7	1.6	0.3	0.2	-1.0	-0.6	-1.6
Breast cancer (self-reported)	0.9	1.1	4.3	-2.1	-0.2	-0.9	0.8	-0.9	0.6	-0.8
Average weekly beer plus cider intake	0.9	1.3	6.6	-0.1	2.6	0.9	0.9	0.7	0.7	-0.5
Pain experienced in last month	0.9	1.4	2.9	1.4	-0.2	0.1	-1.7	1.3	-1.3	1.3
Basal cell carcinoma (self-reported)	0.9	1.0	2.4	1.3	-0.0	-1.6	-1.3	0.1	-0.5	1.1
Bipolar Disorder (2018)	0.8	1.2	3.0	-0.6	1.7	1.6	0.2	-1.6	0.0	0.0
Alzheimer’s Disease (in mother)	0.8	0.9	3.8	0.9	-0.8	-0.2	-0.6	0.8	0.2	1.9
Lupus	0.8	1.2	7.3	-0.8	-0.4	-0.3	0.1	-0.1	2.7	-0.2
Relative age of first facial hair	0.8	1.7	4.0	-2.0	1.6	0.0	1.7	-0.6	0.2	-1.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.9	0.3	-1.1	-0.1	-1.4	-0.9	-1.4	0.8
Hearing difficulty/problems with background noise	0.8	1.2	4.2	-0.4	1.2	-0.6	2.0	1.4	0.3	-0.5
Allergy	0.8	1.8	4.6	0.6	-1.6	-1.2	-2.1	-1.1	-1.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	5.8	0.6	-1.5	0.6	0.3	0.4	-2.4	0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	6.0	2.0	-0.9	0.2	-0.7	0.4	-2.4	1.2
Pulse wave reflection index	0.8	1.0	2.9	-1.7	0.3	0.7	1.2	-0.9	0.0	-1.2
Forced vital capacity (FVC), Best measure	0.8	2.9	8.8	-0.3	-0.9	-0.6	1.4	-2.8	-3.0	-0.8
Eye problems/disorders: None of the above	0.8	0.9	3.0	0.8	-1.0	-0.7	-1.7	0.2	-0.6	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.1	-1.3	-0.0	1.6	-0.2	0.5	2.0	-0.7
Unable to work because of sickness or disability	0.8	1.1	2.2	-1.0	1.2	-0.8	0.3	-1.0	-1.1	-1.5
Depression (Nagel 2018)	0.7	1.1	4.5	0.3	-0.9	0.5	-0.5	0.5	-2.1	1.1
Respiratory disease	0.7	1.7	3.3	-0.5	1.0	1.6	0.9	1.2	1.8	-1.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.3	-0.9	1.8	1.1	0.6	-0.4	-0.2	-0.9
Medication for hormone replacement therapy	0.7	0.8	1.3	1.1	-1.1	-0.5	-0.3	0.7	1.1	1.0
Trunk fat mass	0.7	3.1	9.9	-1.0	3.1	0.4	1.3	-0.9	2.3	-1.6
Heart attack	0.7	0.9	3.1	-0.5	-0.6	-1.8	0.7	1.0	0.9	-0.1
Trunk fat-free mass	0.7	4.3	16.0	-2.1	1.9	0.8	0.7	-4.0	-0.2	-2.2
Prospective memory result	0.7	0.8	1.9	0.1	-0.9	-1.4	-1.2	-1.0	-0.5	0.6
Trunk predicted mass	0.7	4.2	15.7	-2.1	1.9	0.7	0.7	-4.0	-0.2	-2.2
Tense / ‘highly strung’	0.7	1.2	4.1	0.7	0.5	-1.6	-2.0	0.2	0.8	-0.0
Birth weight of first child	0.7	1.3	3.7	-1.9	-0.2	0.2	1.9	-0.9	0.8	-0.7
Blood clot in the leg (DVT)	0.7	0.9	4.0	-0.6	-0.2	-0.3	2.0	0.9	0.7	0.6
Arm predicted mass (right)	0.7	3.8	9.6	-1.9	2.7	1.2	0.8	-3.1	0.3	-1.9
Comparative height size at age 10	0.7	3.7	15.0	-1.5	0.8	1.1	0.6	-3.9	0.6	-2.4
Number of full sisters	0.7	0.8	2.0	-0.0	0.9	-1.4	-1.2	0.4	-1.1	-0.4
Knee pain experienced in last month	0.7	1.0	3.8	0.1	0.3	-0.3	1.4	1.2	1.9	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.5	0.9	-1.1	0.8	-1.2	0.5	-0.5	1.2
Asthma (self-reported)	0.7	1.4	5.9	-0.5	0.9	2.4	0.9	0.5	0.2	-1.3
Average weekly champagne plus white wine intake	0.7	1.0	3.9	0.4	-2.0	-1.4	-0.5	-0.2	0.1	0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.4	0.1	0.2	-0.6	1.1	1.8	1.0	0.0
Medication: Atorvastatin	0.7	0.8	1.8	-1.4	1.0	-0.6	-0.1	0.0	0.9	-1.3
Leg fat percentage (left)	0.7	2.4	7.1	-0.4	2.7	-0.7	1.0	0.7	2.6	-0.8
Fractured/broken bones in last 5 years	0.7	0.8	1.8	-0.4	1.3	1.0	0.8	-1.1	-1.0	0.1
Age started oral contraceptive pill	0.7	0.9	3.6	-0.4	-1.3	0.3	0.1	-0.6	-1.9	-0.3
Commuting to job workplace: Cycle	0.7	0.9	2.4	0.4	0.0	0.7	-0.8	-0.6	-1.6	1.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.2	-0.6	-0.1	-0.2	2.0	0.9	0.6	0.6
Heart disease (siblings)	0.7	0.8	1.9	-1.4	1.3	1.0	0.3	0.4	-0.9	-0.3
Arm predicted mass (left)	0.7	3.7	9.4	-2.0	2.5	0.8	0.8	-3.1	0.7	-2.0
Ulcerative Colitis (UC)	0.6	1.1	6.6	-0.3	2.6	-0.2	0.7	-0.3	0.5	-0.1
Primary Biliary Cirrhosis	0.6	0.9	4.2	0.5	-1.1	-2.1	-0.4	0.5	0.2	0.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	-0.8	1.2	-1.0	0.1	-1.1	0.5	-0.4
Vitamin and mineral supplements	0.6	0.8	4.2	-0.5	-0.6	0.3	0.4	-0.5	-2.0	-0.5
Supplements: Zinc	0.6	0.6	1.0	-0.9	0.7	-0.6	-0.8	-1.0	-0.4	-0.9
Diabetes (mother)	0.6	0.8	3.1	-0.3	1.8	-0.0	0.7	0.1	1.2	-0.7
Trunk fat percentage	0.6	2.4	7.8	-0.5	2.8	0.1	1.2	-0.1	2.5	-1.1
Average weekly fortified wine intake	0.6	0.6	1.9	0.9	0.2	-0.6	-1.4	0.1	-1.2	0.2
Maternal smoking around birth	0.6	0.8	1.9	-0.6	0.6	1.4	1.0	-0.2	1.2	-0.9
Forced vital capacity (FVC)	0.6	2.2	6.0	-0.2	-0.2	-0.8	1.4	-2.4	-2.5	-1.0
Weight	0.6	3.0	7.4	-1.3	2.7	0.5	1.2	-1.9	1.7	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	0.8	-0.3	-0.9	-0.7	0.6	-1.5	0.5
Asthma	0.6	1.2	5.4	-0.3	0.7	2.3	0.9	0.5	0.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.1	0.7	-0.3	0.3	-0.9	-1.2	-1.5	0.1
Depression (self-reported)	0.6	0.7	1.9	0.4	-0.7	0.8	-0.4	0.3	-1.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	6.5	0.0	-1.3	-0.9	1.3	-1.7	-2.6	-0.4
Pulse wave Arterial Stiffness index	0.6	0.7	2.2	-0.5	1.5	1.0	0.2	-0.8	-0.5	-0.5
Length of working week for main job	0.6	0.7	2.2	1.5	-0.7	1.0	-0.9	-0.2	0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.7	0.8	-0.8	-0.5	-0.5	0.3	-1.9	0.6
Loud music exposure frequency	0.6	0.6	1.4	0.6	1.1	-1.2	-1.1	0.3	-0.1	0.0
Headache pain in last month	0.6	1.0	3.9	-1.1	-0.4	0.5	1.0	-2.0	-0.3	-0.6
Gout (self-reported)	0.6	0.9	2.6	0.4	1.6	0.9	0.9	0.4	1.2	-0.3
High blood pressure (siblings)	0.6	0.9	4.4	0.4	1.2	0.2	2.1	0.3	0.3	0.2
Arm fat-free mass (right)	0.6	2.9	7.7	-1.7	2.1	1.2	0.7	-2.8	0.4	-1.7
Age at first live birth	0.6	1.0	3.2	0.3	-0.1	0.0	-0.1	0.9	-1.7	1.8
Shortness of breath walking on level ground	0.6	0.7	1.8	-0.5	0.9	-0.2	1.0	-0.8	-0.3	-1.3
Whole body fat mass	0.6	2.5	8.7	-0.6	3.0	0.3	1.1	-0.3	2.3	-1.2
Leg fat mass (right)	0.6	2.3	8.9	-0.5	3.0	0.2	0.8	0.3	2.3	-0.9
Suffer from ‘nerves’	0.6	1.0	2.5	0.6	-0.5	-0.2	-1.5	0.6	-1.6	1.0
Age at last live birth	0.6	0.8	2.1	0.0	-0.1	-0.9	-0.4	0.9	-1.4	1.3
Family relationship satisfaction	0.6	0.7	1.6	0.9	-0.2	1.1	-1.0	0.3	1.2	-0.7
Whole body fat-free mass	0.6	3.5	12.6	-1.8	1.9	0.9	0.4	-3.5	0.3	-1.9
Average weekly red wine intake	0.6	0.9	2.4	-0.9	-1.6	-0.2	0.3	-1.1	-1.1	0.7
Loneliness, isolation	0.6	0.9	4.5	-0.6	0.8	0.1	0.6	-0.3	-2.1	-0.6
Ever taken oral contraceptive pill	0.6	0.7	1.4	0.2	-0.8	-1.2	1.1	0.7	0.9	-0.2
Basal metabolic rate	0.6	3.2	9.8	-1.6	2.1	0.8	0.7	-3.1	0.7	-1.9
Arm fat-free mass (left)	0.6	3.2	9.3	-1.8	2.2	0.7	0.9	-3.1	0.6	-1.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-1.0	-0.2	-0.7	0.9	-1.2	-1.0	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.6	-0.6	-0.2	-1.6	0.6	0.8	1.1	-0.0
Leg fat mass (left)	0.6	2.3	9.2	-0.5	3.0	0.3	1.0	-0.0	2.2	-1.0
Schizophrenia (2018)	0.5	1.0	2.4	1.0	-1.2	-0.2	-1.6	1.4	0.6	0.0
Coronary Artery Disease (CAD)	0.5	0.5	2.5	0.2	1.1	-0.1	1.6	0.1	0.0	0.0
BMI	0.5	2.7	4.4	1.5	2.0	1.5	-0.4	1.9	2.1	1.3
Systolic Blood Pressure	0.5	2.4	4.6	-0.9	2.2	-0.9	1.5	-0.7	2.0	-2.0
Lung FEV1/FVC ratio	0.5	2.8	6.2	2.5	-1.9	-0.3	-0.0	2.0	-0.8	2.2
Chronotype (morning person)	0.5	1.1	3.0	-1.6	0.6	-0.3	0.0	-0.4	1.7	-1.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.5	-0.9	-0.5	0.4	0.3	-1.6	-0.0	-0.1
Had other major operations	0.5	0.6	2.4	-1.0	0.0	-0.9	-0.0	0.1	1.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.3	-0.2	1.1	-0.4	-0.3	-1.5	-0.9	0.1
Diabetes (self-reported)	0.5	0.8	1.4	-0.8	1.1	0.7	0.9	-0.0	1.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.4	0.2	-0.9	-0.8	1.5	-1.5	-2.3	-0.5
Medication: Lansoprazole	0.5	0.6	1.1	0.1	-1.0	-1.0	0.4	0.1	0.8	1.0
Breastfed as a baby	0.5	0.6	1.4	-0.8	1.2	-0.7	-0.1	-0.5	0.3	1.0
Hair/balding pattern: Pattern 4	0.5	1.1	2.4	-1.1	0.6	-1.0	-1.2	-1.6	0.1	-1.3
Peak expiratory flow (PEF)	0.5	1.2	4.5	0.8	-0.7	-1.3	0.3	0.4	-2.1	0.8
Body fat percentage	0.5	2.1	6.5	-0.1	2.5	-0.2	0.9	0.5	2.5	-0.7
Leg fat percentage (right)	0.5	1.9	5.7	-0.1	2.3	-0.8	0.6	1.0	2.4	-0.4
Health satisfaction	0.5	0.7	1.8	0.2	1.4	1.2	-0.5	1.0	-0.5	0.1
Leg pain on walking	0.5	0.6	2.0	0.4	-0.2	-0.1	0.4	1.2	-1.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.9	0.4	-0.9	-0.1	1.1	0.4	-2.2	0.5
Whole body water mass	0.5	3.1	11.5	-1.6	1.8	0.9	0.4	-3.4	0.2	-1.8
Financial situation satisfaction	0.5	0.6	1.8	-0.4	-0.0	0.7	0.8	1.4	0.6	-0.8
Alcohol drinker status: Never	0.5	0.5	2.3	0.1	0.3	1.5	-0.3	-0.3	0.8	-0.7
Breast Cancer	0.4	1.0	4.9	0.3	-1.0	-0.1	0.4	2.2	0.9	0.3
Prostate Cancer	0.4	0.6	2.8	-0.3	-0.4	0.1	0.6	-0.4	-1.7	0.5
HDL Cholesterol	0.4	0.6	1.8	-1.3	0.8	-0.6	0.6	-0.2	0.4	-0.9
Neuroticism (2016)	0.4	0.6	1.3	-0.1	-0.4	-1.0	-0.6	-1.1	0.8	0.7
Schizophrenia (2014)	0.4	0.9	3.6	1.1	-0.7	0.1	-1.9	1.0	0.0	0.0
Triglycerides	0.4	0.7	1.7	0.5	-0.5	-1.1	-0.7	1.0	0.2	1.3
Blood Eosinophil Count	0.4	3.0	9.0	-1.9	0.6	1.0	2.2	-1.3	0.5	-3.0
Allergy or Eczema	0.4	1.1	2.5	0.1	1.6	1.1	0.7	0.9	1.6	-0.1
Cardiovascular Disease	0.4	1.5	3.3	0.9	1.1	1.2	0.3	1.4	1.8	1.3
Neuroticism	0.4	0.9	3.2	0.8	-0.1	0.5	-1.2	0.7	-0.8	1.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.1	0.2	0.2	0.4	0.8	0.9	-1.4	0.5
Angina	0.4	0.5	1.3	-0.0	-0.4	-0.6	-0.2	0.8	1.1	1.1
Leg fat-free mass (left)	0.4	2.0	6.7	-1.2	1.6	0.7	0.2	-2.6	0.9	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	0.8	0.2	0.5	-1.4	-0.5	-1.1	1.2
High blood pressure	0.4	1.0	2.5	1.1	1.2	0.2	0.5	1.2	1.6	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.7	0.4	1.6	1.2	0.7	0.3	1.0	-0.2
Leg predicted mass (left)	0.4	2.1	6.7	-1.2	1.6	0.6	0.2	-2.6	0.9	-1.5
Number of incorrect matches in round	0.4	0.7	1.7	-0.5	0.8	0.9	1.3	-0.5	-0.3	-1.0
Hair/balding pattern: Pattern 2	0.4	0.6	1.6	0.6	-0.2	-0.9	-0.3	0.6	-1.2	0.8
Had menopause	0.4	0.5	1.8	-0.1	1.3	-0.6	-1.1	0.2	0.1	0.6
Hip circumference	0.4	1.6	4.0	-0.3	1.9	-0.3	0.8	-1.4	2.0	-1.0
Father’s age at death	0.4	0.6	1.2	0.2	-1.1	-0.1	-0.8	-0.9	-0.5	1.1
Happiness	0.4	0.5	2.1	0.4	-0.1	-0.9	-0.5	0.6	-1.5	0.2
Worry too long after embarrassment	0.4	0.7	1.9	1.1	0.3	0.6	-0.0	1.4	0.6	1.1
Pulse wave peak to peak time	0.4	0.5	1.8	0.3	-1.3	-1.0	-0.0	0.4	0.5	0.1
Angina (self-reported)	0.4	0.6	1.4	-0.1	-0.3	-0.8	0.1	0.9	1.2	1.0
Migraine (self-reported)	0.4	0.5	1.3	1.0	-0.0	0.9	-0.7	-1.1	0.2	0.1
Medication: Seretide 50 evohaler	0.4	0.5	1.1	1.1	-0.8	0.3	-0.5	0.1	-0.8	0.9
Chest pain or discomfort	0.4	0.6	1.7	0.3	-0.9	0.0	0.6	1.3	1.0	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.7	0.1	0.2	0.3	-1.6	-0.3	0.7	0.0
Hypertension (Self-reported)	0.4	1.0	2.5	0.8	1.3	0.3	0.6	1.1	1.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.7	0.8	1.3	0.2	0.5	0.5	-0.2	0.5
Illnesses of father: Heart disease	0.4	0.5	1.9	0.6	-0.1	-0.6	1.4	0.3	-0.5	0.7
Leg fat-free mass (right)	0.4	2.3	7.6	-1.4	1.7	0.7	0.2	-2.8	0.8	-1.6
Commuting to job workplace: Walk	0.4	0.5	1.9	-1.4	-0.7	-0.1	0.6	-0.5	-0.3	0.3
Medication: Gliclazide	0.4	0.5	1.1	0.2	-1.1	0.9	0.7	-0.1	0.6	-0.7
Leg predicted mass (right)	0.4	2.3	7.3	-1.4	1.7	0.7	0.2	-2.7	0.9	-1.6
Arm fat mass (left)	0.4	1.6	5.6	0.0	2.4	0.3	0.8	0.3	2.1	-0.6
Medication: Bendroflumethiazide	0.4	0.7	2.1	-0.7	1.4	-1.0	0.1	-0.6	0.5	-0.6
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.4	-1.1	-1.0	-0.1	-0.5	-1.2	-1.5	-0.7
Cholesterol lowering medication	0.4	0.6	1.3	0.6	-0.3	0.7	-1.1	1.2	0.3	0.7
Ovarian Cancer	0.3	0.4	1.5	-0.4	0.5	-0.9	1.2	-0.0	0.7	0.2
Rheumatoid Arthritis	0.3	0.5	2.2	1.5	0.0	0.3	0.9	0.4	0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	0.3	0.2	1.1	0.5	0.7	0.0	0.0
Ulcerative Colitis	0.3	0.4	1.4	0.5	0.9	-0.2	-0.6	-1.2	0.0	0.0
Tanning	0.3	3.3	6.5	-2.3	1.7	-2.5	0.3	-1.8	-0.8	-2.1
Hand grip strength (left)	0.3	0.7	1.9	-0.7	-0.8	0.5	-0.4	-1.1	-1.4	-0.6
Medication: Metformin	0.3	0.4	1.0	0.6	0.4	1.0	-0.4	0.8	-0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.5	-0.1	0.4	-1.0	1.0	-0.4	0.6
Relative age voice broke	0.3	0.5	1.4	-1.2	1.1	0.4	0.6	-0.0	0.3	-0.6
Age when periods started (menarche)	0.3	0.7	2.6	-0.6	-0.3	0.0	-1.6	0.1	-1.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.2	-0.3	0.3	-0.7	-0.6	1.0	0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	0.6	-0.4	1.0	-0.4	-0.0	0.5	-0.5
Body mass index (BMI)	0.3	1.3	3.8	0.5	1.9	0.3	0.2	1.0	2.0	0.2
Impedance of leg (left)	0.3	1.3	3.0	-1.4	0.9	-0.5	1.6	-0.9	-0.4	-1.7
Nervous feelings	0.3	0.5	1.2	0.0	-0.5	0.2	-0.9	1.1	-0.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.5	0.7	0.2	0.1	-1.3	0.2	-1.6	0.8
Arm fat percentage (right)	0.3	1.1	3.2	0.9	1.4	0.1	0.3	1.4	1.8	0.4
Time employed in main current job	0.3	0.4	0.7	0.5	0.8	0.6	0.2	-0.5	-0.8	0.8
Number of live births	0.3	0.4	1.2	-0.1	-0.1	-1.1	-0.2	1.0	0.2	0.6
Arm fat mass (right)	0.3	1.4	4.6	0.1	2.1	0.4	0.6	0.4	2.2	-0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	0.1	-0.4	0.6	0.7	0.7	-0.9	0.1
Medication: Amlodipine	0.3	0.4	0.9	0.1	1.0	0.7	-0.7	0.9	-0.3	0.6
Birth weight	0.3	0.7	2.8	-0.0	0.5	1.7	1.2	-0.6	-0.0	0.2
Supplements: Vitamin C	0.3	0.4	1.8	0.2	-1.4	-0.3	-0.0	-0.3	-0.3	0.5
Arm fat percentage (left)	0.3	1.2	3.3	0.8	1.5	0.0	0.3	1.4	1.8	0.3
Diabetes diagnosed by doctor	0.3	0.5	1.3	-0.1	0.6	0.8	0.7	0.3	1.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.4	0.3	0.1	-0.6	0.1	-0.3	1.2	-0.8
Osteoporosis (self-reported)	0.3	0.4	1.1	-0.3	0.6	-0.1	-0.7	-1.0	-0.8	-0.3
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.4	-0.7	-0.6	0.1	-0.9	0.2	-1.0
Medication: Aspirin	0.3	0.4	2.0	-0.2	0.3	0.2	0.2	0.5	1.4	0.2
Guilty feelings	0.3	0.5	2.0	0.0	0.7	-0.6	0.3	-0.7	-1.4	0.6
Wears glasses or contact lenses	0.3	0.4	1.8	0.6	-0.2	-0.6	0.0	0.1	-0.2	1.4
Risk taking	0.3	0.4	1.4	-0.2	1.2	0.2	0.1	-1.0	0.2	-0.4
Diastolic blood pressure, automated reading	0.3	0.8	2.0	-0.2	1.4	1.0	0.3	-0.7	1.1	-1.0
Depressed Affect (Nagel 2018)	0.2	0.3	0.9	0.3	0.4	0.7	-0.1	0.3	-0.9	0.9
Neuroticism (Nagel 2018)	0.2	0.6	1.9	0.6	-0.7	0.2	-0.5	0.3	-1.0	1.4
Worry (Nagel 2018)	0.2	0.5	2.0	0.8	-0.5	-0.0	-0.5	0.3	-0.1	1.4
Bipolar Disorder (2011)	0.2	0.2	1.2	-1.1	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.2	1.3	5.8	1.3	0.7	0.3	-0.4	0.9	2.4	-0.2
Heel T-Score	0.2	1.2	3.2	-0.6	-1.1	-1.1	-0.6	0.5	-1.8	1.4
Lung FVC	0.2	1.3	3.5	-0.4	0.0	-1.9	1.5	-0.7	-1.3	-0.8
Sensitivity / hurt feelings	0.2	0.3	1.3	0.2	-1.1	0.2	-0.2	0.8	0.0	0.7
Systolic blood pressure, automated reading	0.2	0.5	1.8	0.0	1.4	0.6	-0.2	-0.1	0.9	-0.5
Medication: Co-codamol	0.2	0.3	0.6	-0.2	0.7	-0.6	0.1	0.2	-0.6	0.7
Hand grip strength (right)	0.2	0.6	1.1	-0.9	0.2	1.0	0.3	-0.4	-1.1	-0.9
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.9	-0.0	0.8	0.2	-0.5	0.7	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.8	0.8	-0.9	0.5	-0.3	0.6	0.6	0.5
Neuroticism score	0.2	0.4	0.8	0.4	0.7	0.5	-0.2	0.2	-0.9	0.9
Impedance of arm (right)	0.2	0.8	1.7	-0.6	-0.9	-1.3	0.5	-0.5	-0.6	-1.3
Worrier / anxious feelings	0.2	0.4	1.5	0.4	0.7	0.4	0.4	0.5	-0.6	1.2
Exposure to tobacco smoke outside home	0.2	0.2	0.9	-0.6	0.0	-0.0	-0.1	-0.9	-0.5	-0.3
Number of children fathered	0.2	0.2	0.5	-0.7	0.4	-0.2	0.6	0.3	-0.7	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.8	0.1	-0.2	0.3	0.5	-0.5	-0.9	-0.0
Medication: Ibuprofen	0.2	0.2	0.5	0.7	-0.4	0.5	-0.7	-0.3	-0.1	0.3
Alcohol intake frequency.	0.2	0.6	1.6	-0.2	1.0	1.1	-0.1	-0.2	-0.3	-1.2
Medication: Aspirin	0.2	0.3	0.9	-0.4	0.4	-0.1	0.8	0.4	0.9	-0.2
Mood swings	0.2	0.3	1.8	-0.3	1.3	0.6	-0.4	0.0	-0.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.9	-0.0	-0.6	0.2	-0.3	-0.3	-0.4
Friendships satisfaction	0.2	0.2	0.6	-0.2	0.8	0.3	-0.5	0.4	0.0	-0.7
Qualifications: nursing, teaching	0.2	0.4	0.9	0.6	-0.2	-0.3	-1.0	0.4	0.6	0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	-0.2	-0.4	0.6	-0.9	-0.2	0.1	0.3
Medication: Blood pressure	0.2	0.4	0.9	-0.7	0.6	-0.3	0.2	-0.9	0.2	-0.9
Irritability	0.2	0.3	1.6	0.0	-0.2	-0.0	-1.2	-0.3	0.0	0.5
Myopia	0.2	0.3	1.7	0.5	-0.3	-1.3	0.3	-0.1	-0.1	0.1
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.0	-0.3	-0.0	-0.8	-0.1	-0.3	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.4	0.2	1.0	-0.9	-0.2	0.6	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.7	0.6	0.1	-0.4	0.1	0.2	0.6
Blood Platelet Count	0.1	0.7	1.2	0.0	1.0	1.0	0.8	-1.1	0.1	-0.9
Blood Red Count	0.1	1.0	3.3	0.4	1.8	1.2	-0.8	0.3	0.1	-1.0
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.6	0.3	0.6	0.7	-0.0	-0.0	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.0	-0.0	0.2	1.0	0.3	0.4	0.0	-0.2
Impedance of leg (right)	0.1	0.6	1.5	-0.8	0.2	-0.6	1.2	-0.5	-0.5	-1.2
Fed-up feelings	0.1	0.2	0.6	-0.7	0.6	0.2	0.0	-0.3	-0.6	-0.1
Financial difficulties in last 2 years	0.1	0.2	1.0	-1.0	0.2	-0.2	0.5	0.1	-0.1	-0.0
Medication: Ramipril	0.1	0.2	0.6	-0.2	0.4	-0.8	0.5	0.4	0.1	0.1
Impedance of arm (left)	0.1	0.6	1.7	-0.2	-1.1	-1.3	0.4	-0.3	-0.5	-1.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.9	-0.1	0.1	0.2	0.2	-0.2	-0.9	-0.1
Glaucoma (self-reported)	0.1	0.2	0.6	-0.1	-0.1	-0.3	-0.6	-0.4	0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	-0.9	0.5	0.6	0.3	-0.1	-0.0	0.3
Comparative body size at age 10	0.1	0.4	1.0	0.9	0.3	-0.3	0.5	0.7	-0.3	1.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.0	-0.1	0.7	-0.5	0.1	-0.2	-0.1
Medication for cholesterol	0.1	0.2	0.8	-0.4	-0.2	0.4	0.5	-0.2	-0.9	0.4
Miserableness	0.1	0.2	0.6	-0.2	0.6	0.5	0.8	-0.5	-0.1	0.1
Impedance of whole body	0.1	0.7	1.7	-0.9	-0.4	-0.9	1.0	-0.4	-0.4	-1.3
Hair Pigment	0.0	1.1	4.2	-1.5	0.4	0.6	0.5	0.2	2.1	-0.5

Hub : Genes

PCK2

Models

Trait associations