Hub : Genes

RIPK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1230	0.0450	3.4e-03	0.076	NA	0.023	NA	0.048	8.6e-07	NA	4.9e-03	NA	7.9e-05
2	GTEx	Esophagus Mucosa	0.2780	0.0580	2.9e-06	0.132	NA	0.112	NA	0.112	4.2e-09	NA	6.8e-08	NA	6.4e-08
3	GTEx	Skin Sun Exposed Lower leg	0.1550	0.0400	8.2e-06	0.124	NA	0.106	NA	0.138	1.9e-10	NA	4.8e-09	NA	1.7e-11
4	GTEx	Thyroid	0.2990	0.0580	6.7e-08	0.094	NA	0.145	NA	0.107	1.1e-07	NA	3.4e-11	NA	1.4e-08
5	GTEx	Uterus	0.6160	0.1250	2.5e-03	0.134	NA	0.012	NA	0.201	1.2e-03	NA	1.8e-01	NA	6.6e-05
6	METSIM	Adipose	0.0375	0.0187	1.2e-02	0.012	0.005	0.008	0.011	0.009	4.8e-03	4.9e-02	1.7e-02	0.0083	1.6e-02
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.1049	0.0372	6.0e-08	0.038	0.058	0.077	NA	0.071	3.4e-05	4.1e-07	5.8e-09	NA	1.9e-08
8	TCGA	Brain Lower Grade Glioma	0.0572	0.0271	9.7e-04	0.003	0.012	0.013	NA	0.003	1.3e-01	1.5e-02	1.1e-02	NA	1.4e-01
9	TCGA	Prostate Adenocarcinoma	0.0482	0.0222	6.8e-04	0.011	0.030	0.030	NA	0.027	2.4e-02	3.9e-04	4.2e-04	NA	6.8e-04
10	TCGA	Testicular Germ Cell Tumors	0.2450	0.1040	2.1e-03	0.018	0.027	0.075	NA	0.012	7.6e-02	3.7e-02	1.2e-03	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.6	1.0	2.6	1.0	1.1	0.7	-1.3	0.5	-0.7	1.3	0.5	0.5	1.6
Bipolar Disorder or Schizophrenia	1.2	3.0	4.2	1.8	1.9	1.7	-2.0	1.4	0.6	2.0	1.4	1.8	2.0
Depressed Affect (Nagel 2018)	0.1	0.1	0.9	-0.0	0.0	-0.2	0.5	0.9	0.2	0.0	0.3	-0.1	-0.5
Depression (Nagel 2018)	0.2	0.4	2.4	-0.4	-0.6	-0.2	0.5	-0.2	-0.6	-0.0	-0.3	0.1	-1.5
Intelligence (Savage-Jansen 2018)	0.1	0.5	2.0	0.1	-0.4	0.3	-0.6	1.1	0.6	0.5	-0.3	-0.1	-1.4
Neuroticism (Nagel 2018)	0.1	0.2	1.1	0.1	0.1	0.1	0.6	1.0	-0.2	-0.2	0.5	-0.4	-0.0
Schizophrenia (2018)	1.1	2.3	3.9	1.5	1.6	1.6	-1.5	1.4	1.3	1.6	1.4	2.0	1.2
Schizophrenia vs Biploar Disorder	0.9	1.1	3.0	-1.3	-1.4	-1.1	1.5	0.7	-0.5	-1.7	-0.6	-0.7	0.1
Worry (Nagel 2018)	0.2	0.5	1.6	0.6	0.5	0.8	0.0	1.3	-0.4	0.4	0.7	0.1	1.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	0.2	0.2	0.3	-0.6	0.9	-0.1	0.1	0.1	-0.6	0.2
Alzheimer’s Disease (in father)	0.6	0.7	1.4	-1.0	-0.9	-0.8	1.1	-1.2	0.3	-1.0	-0.6	-0.3	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	1.4	-0.8	-0.8	-0.6	0.5	-0.5	-0.2	-0.8	-0.3	-1.2	-0.5
Crohns Disease (2017)	0.9	2.1	6.7	-1.5	-1.4	-1.0	2.0	-0.9	-0.3	-1.9	-0.6	-0.3	-2.6
Irritable Bowel Disease (IBD)	0.5	1.2	3.5	-1.1	-0.9	-0.8	1.7	0.0	0.6	-1.5	0.3	0.3	-1.9
Ulcerative Colitis (UC)	0.4	0.8	1.6	-0.9	-0.7	-0.9	1.3	1.1	1.0	-0.9	0.3	0.1	-1.0
Major Depression (MDD)	1.6	1.9	5.4	1.4	1.7	1.2	-1.5	2.0	0.2	2.3	0.4	0.5	0.6
Reaction Time	1.5	2.8	7.6	-2.1	-2.0	-1.2	2.8	-0.2	-1.1	-1.9	-0.8	-0.9	-2.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.5	0.8	0.4	0.7	-0.8	1.9	1.1	0.3	1.5	0.5	-0.7
Breast Cancer	0.6	1.5	2.9	1.2	1.3	1.6	-1.0	-0.3	1.5	1.2	0.8	1.7	0.7
Ovarian Cancer	1.9	2.5	6.5	1.1	1.3	1.6	-0.6	0.2	2.3	0.7	2.5	2.1	1.6
Prostate Cancer	0.9	1.3	4.4	-0.8	-0.6	-1.1	0.6	-0.8	-2.1	-1.1	-1.1	-1.7	-0.5
Age at First Birth	0.7	1.0	2.8	0.8	1.0	0.9	-1.5	1.7	0.5	1.0	0.8	0.8	0.6
Bipolar Disorder (2011)	1.7	1.6	2.7	1.4	1.3	1.3	-1.1	0.4	1.3	1.6	1.2	1.4	1.3
Body Mass Index (BMI) (2010)	0.9	1.3	3.1	-1.3	-1.0	-1.4	1.4	0.1	-1.0	-1.8	-0.9	-1.0	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.2	-0.3	-0.4	0.1	0.1	0.3	-0.6	-0.0	0.1	-0.3
Crohns Disease (2012)	0.5	0.7	2.6	-0.2	-0.3	0.4	0.5	-0.1	1.3	-0.5	1.0	1.6	-1.1
Mean Putamen Volume	2.1	2.4	4.5	1.7	1.6	1.4	-1.5	2.1	0.3	1.2	1.7	1.2	2.0
Fasting Glucose	1.9	2.2	4.2	-1.8	-2.0	-1.8	1.6	-0.0	-0.9	-1.7	-1.5	-1.4	-0.9
HbA1C	0.3	0.4	1.5	0.7	0.2	0.5	-0.0	-1.2	0.1	0.8	0.3	0.3	-0.6
HDL Cholesterol	0.3	0.4	2.0	-0.6	-0.5	-0.3	0.7	-1.4	-0.6	-0.4	-0.7	0.2	0.5
LDL Cholesterol	0.9	1.5	4.9	0.5	0.5	1.3	-0.8	0.2	1.9	0.5	2.2	1.7	-0.3
Lupus	2.1	3.2	6.6	2.4	2.4	1.7	-2.6	0.8	0.6	2.1	1.0	1.1	1.7
Neuroticism (2016)	0.2	0.3	0.8	-0.4	-0.3	-0.3	0.3	0.5	-0.5	-0.1	-0.9	-0.6	-0.8
Primary Biliary Cirrhosis	0.2	0.2	1.2	-0.1	-0.0	-0.3	0.2	0.2	-0.7	-0.4	-0.5	-0.4	1.1
Rheumatoid Arthritis	3.1	4.3	14.4	1.8	2.0	1.7	-1.7	3.8	1.7	2.2	0.9	1.0	2.4
Schizophrenia (2014)	0.9	2.0	3.2	1.4	1.5	1.6	-1.6	1.1	0.8	1.5	1.2	1.8	1.4
Triglycerides	1.0	1.6	3.5	-1.5	-1.1	-1.6	1.0	-0.1	-0.2	-1.9	-1.4	-0.4	-1.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	-0.3	-0.3	-0.2	-0.3	-1.4	-1.1	0.5	-1.2	-0.4	-0.8
Ulcerative Colitis	1.0	1.5	3.1	1.1	1.0	0.8	-0.8	1.5	1.7	0.8	1.8	1.5	0.7
Blood Eosinophil Count	0.1	0.8	6.6	-0.2	-0.2	-0.2	0.9	2.6	-0.0	-0.2	-0.3	0.6	-0.2
Blood Platelet Count	0.4	4.5	9.8	2.1	2.2	2.2	-1.9	3.1	1.7	2.3	2.5	1.8	0.1
Blood Red Count	1.2	12.0	20.2	-4.3	-4.5	-3.5	4.5	-0.6	-1.9	-3.6	-3.1	-2.8	-3.8
Blood White Count	0.3	2.0	18.1	-0.2	-0.2	-0.1	0.7	4.3	0.5	-0.3	0.5	-0.0	0.7
Heel T-Score	0.7	5.4	24.0	0.1	0.4	2.4	0.1	-0.9	4.0	1.0	1.8	4.9	-1.6
BMI	0.3	1.7	3.8	1.9	1.7	1.6	-1.3	0.7	0.8	1.6	1.0	0.8	0.8
Height	1.0	19.5	49.8	3.4	3.1	-0.6	-3.0	4.0	-7.1	2.4	-1.9	-6.8	6.5
Waist Hip Ratio (WHR)	0.1	0.4	1.0	0.7	0.4	0.4	-0.6	0.2	-1.0	1.0	0.2	-0.4	-0.5
Systolic Blood Pressure	2.7	13.6	21.2	4.6	4.6	4.0	-3.6	2.1	2.8	4.3	3.1	2.8	4.0
Smoking Status	1.9	4.5	10.9	2.0	2.0	2.1	-1.5	2.0	2.4	1.6	3.3	2.0	1.9
Allergy or Eczema	0.1	0.2	0.9	0.5	0.2	0.3	-0.7	0.1	0.3	0.4	-0.5	-0.1	-1.0
Cardiovascular Disease	2.1	7.0	14.4	3.1	3.2	3.2	-2.2	2.2	1.1	3.8	1.9	1.2	3.1
Hypothyroidism (self reported)	0.3	0.8	2.7	-0.5	-0.3	-0.6	0.6	1.6	-1.0	-0.5	-0.7	-1.2	1.0
Respiratory disease	0.6	1.3	3.6	-0.7	-1.0	-0.7	0.5	-1.9	-1.0	-0.0	-1.4	-0.9	-1.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.0	-0.1	-0.1	-0.1	1.0	0.0	-0.4	-0.3	0.6	-0.2	0.0
Lung FEV1/FVC ratio	0.4	2.1	7.5	-1.1	-1.4	-1.2	1.6	0.0	-2.7	-0.3	-1.0	-2.2	-0.5
Lung FVC	0.2	1.1	4.1	0.4	1.0	0.8	-1.0	1.0	1.2	1.0	0.4	0.8	2.0
Neuroticism	0.1	0.4	2.0	-0.0	-0.0	0.1	0.7	1.4	-0.6	-0.0	-0.0	-0.7	-0.4
Chronotype (morning person)	0.3	0.7	5.3	-0.1	-0.2	0.0	-0.0	-2.3	-0.7	0.6	-0.8	-0.3	-0.1
Hair Pigment	0.0	0.4	1.0	-0.1	-0.1	0.6	0.4	1.0	0.9	-0.2	1.0	0.3	0.6
Tanning	0.3	3.3	6.9	-2.1	-2.0	-2.1	2.6	-1.6	-1.4	-1.7	-1.9	-1.4	-0.4
Hand grip strength (left)	0.7	1.9	4.2	1.8	1.5	1.2	-2.0	0.0	-0.2	1.9	0.7	-0.2	2.1
Number of treatments/medications taken	1.5	2.6	7.3	2.0	2.1	1.8	-1.9	0.1	0.9	2.7	1.3	0.8	0.9
Average weekly spirits intake	0.3	0.3	0.5	0.4	0.7	0.6	-0.4	-0.6	0.7	0.7	0.1	0.3	-0.7
Sensitivity / hurt feelings	0.2	0.3	0.7	0.4	0.6	0.8	0.1	-0.2	-0.3	0.2	0.9	0.1	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.5	0.4	0.7	-0.1	0.1	0.1	0.9	0.6	0.6	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.5	0.4	0.2	-0.7	0.5	0.0	0.8	-0.4	0.0	-0.1
Relative age of first facial hair	1.3	2.6	7.9	0.9	1.2	1.6	-1.2	-0.2	2.8	0.3	2.1	2.7	0.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.1	-0.8	-0.9	-1.1	1.0	-1.4	-1.4	-0.5	-1.1	-1.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.9	0.1	0.5	-0.5	-0.2	0.5	0.0	-0.2	0.3	-0.9	-0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.9	-0.7	-0.7	-1.2	0.1	-0.0	-0.6	-0.2	-1.4	-1.2	0.2
Systolic blood pressure, automated reading	1.3	3.8	6.3	2.5	2.5	2.1	-1.9	0.5	1.6	2.4	1.7	1.8	1.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-0.6	-0.8	-0.5	0.5	-1.0	-0.2	-0.6	-0.7	-0.1	-0.8
Angina	0.1	0.1	0.5	0.2	0.1	0.1	0.1	-0.7	0.5	0.1	-0.3	-0.2	-0.6
Medication for hormone replacement therapy	0.7	0.8	3.1	-1.0	-0.6	-1.0	0.7	0.1	-0.3	-0.9	-0.9	-1.7	-0.2
Vitamin and mineral supplements	1.5	2.1	10.3	0.6	0.3	0.7	-0.5	3.2	1.5	0.1	1.4	2.2	-0.1
Supplements: Zinc	1.0	1.1	3.5	-0.7	-0.8	-0.8	0.1	-1.1	-1.8	-0.1	-1.2	-1.9	-0.4
Medication: Co-codamol	4.7	5.5	8.9	-2.5	-2.1	-2.5	2.2	-2.2	-3.0	-2.0	-2.5	-2.8	-1.2
Medication: Metformin	0.1	0.1	0.3	0.0	0.2	-0.1	0.3	-0.3	0.3	-0.5	-0.1	0.2	-0.3
Diabetes (father)	1.1	1.3	1.9	1.3	1.2	1.4	-0.7	1.3	1.2	1.4	1.0	1.1	0.5
Diabetes (mother)	0.5	0.6	3.2	-0.3	0.2	-0.1	-0.2	0.2	1.5	0.2	0.0	1.8	0.1
Severe depression (siblings)	1.0	1.1	3.7	-1.1	-1.0	-1.1	1.0	-1.0	-0.9	-1.9	0.2	-0.0	-0.9
Pack years adult smoking proportion	0.6	0.9	1.8	1.3	1.4	1.0	-1.0	-1.0	0.2	1.0	0.7	0.4	0.9
Impedance of leg (right)	0.1	0.7	1.9	-0.9	-1.1	-0.7	0.3	-0.4	0.6	-0.5	-1.3	0.1	-1.4
Leg fat-free mass (left)	1.1	5.7	18.4	3.0	3.0	1.5	-2.1	2.1	-1.5	1.8	1.3	-1.4	4.3
Trunk fat percentage	0.3	1.2	3.7	1.9	1.7	0.8	-1.2	0.7	0.5	1.3	-0.1	0.3	0.8
Hand grip strength (right)	0.9	2.5	9.7	2.0	1.8	1.4	-1.9	-0.2	-0.1	1.6	0.6	-0.0	3.1
Townsend deprivation index at recruitment	1.1	1.6	12.2	-0.7	-0.8	-0.7	0.8	3.5	-0.5	-0.6	0.2	-0.5	-0.6
Current tobacco smoking	1.6	2.6	5.2	1.8	1.8	1.8	-1.3	0.8	1.1	1.6	2.3	1.3	1.9
Average weekly fortified wine intake	0.5	0.6	2.3	-1.2	-0.9	-0.6	1.5	-0.3	-0.2	-1.0	0.1	0.2	0.1
Maternal smoking around birth	0.0	0.1	0.3	0.2	-0.0	0.1	0.2	0.5	0.2	0.4	0.1	-0.1	0.1
Fed-up feelings	0.1	0.2	0.5	0.3	0.1	-0.0	0.5	0.7	-0.4	-0.1	0.1	-0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-0.8	-0.7	-0.4	1.2	0.8	-0.5	-0.4	-0.7	-0.1	-0.8
Relative age voice broke	0.5	0.7	3.5	-0.0	0.4	0.5	-0.0	-0.4	1.9	-0.1	0.8	1.3	0.8
Taking other prescription medications	0.2	0.3	0.7	0.5	0.7	-0.0	-0.8	0.6	0.1	0.6	-0.5	-0.4	-0.4
Age when periods started (menarche)	0.1	0.2	0.8	-0.1	0.1	0.9	0.1	-0.3	0.2	0.5	-0.1	0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.8	-1.1	-1.0	-1.5	0.9	-0.4	-1.6	-1.3	-1.3	-1.9	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.1	0.2	0.2	1.3	-0.0	-0.3	1.6	0.3	0.8	2.0	-0.5
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	4.0	1.8	1.8	1.7	-2.0	1.5	1.3	1.9	1.6	0.6	0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.0	-0.0	-0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.4	0.6
Serious illness, injury or assault to yourself	0.6	0.7	1.6	-0.5	-0.5	-0.7	0.8	0.7	-1.2	-0.0	-1.1	-1.3	-0.6
High blood pressure	1.6	4.4	7.9	2.5	2.8	2.4	-1.8	1.9	0.7	2.8	1.5	0.8	2.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.3	0.1	-0.3	-0.3	-0.4	0.4	-0.1	-0.1	-1.1	-0.8	-1.1
Multivitamins +/- minerals	2.2	2.8	5.6	-1.7	-1.3	-1.5	1.5	-2.4	-1.4	-1.1	-2.1	-2.3	-0.5
Stomach or abdominal pain in last month	0.5	0.6	1.9	-0.4	-0.5	-0.7	1.0	1.4	-1.0	-0.2	-0.2	-0.6	0.5
Supplements: Glucosamine	2.5	3.3	6.9	2.4	2.6	2.1	-1.9	-0.0	0.2	2.1	2.0	1.3	1.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	-0.4	-0.4	-0.5	0.6	-0.1	-0.5	-0.6	0.2	-0.8	-0.8
Medication: Atenolol	1.5	1.9	4.5	1.5	1.6	1.6	-1.4	-0.3	1.0	2.1	1.0	1.3	1.0
Medication: Levothyroxine sodium	1.0	1.7	3.8	1.5	1.9	1.3	-1.3	0.9	0.2	1.3	1.0	0.5	2.0
Sitting height	0.5	3.7	12.8	2.2	1.9	0.3	-2.1	2.2	-1.4	0.5	0.6	-2.0	3.6
Chronic bronchitis/emphysema (father)	2.1	2.5	3.6	-1.9	-1.4	-1.9	1.7	-1.2	-1.5	-1.8	-1.5	-1.2	-1.6
High blood pressure (mother)	2.5	3.5	5.9	2.0	2.1	1.9	-1.8	2.4	1.7	1.8	1.9	1.3	1.6
Body mass index (BMI)	0.4	1.8	3.7	1.9	1.8	1.5	-1.1	1.0	0.9	1.2	1.3	1.2	0.9
Impedance of leg (left)	0.3	1.3	3.8	-1.1	-1.5	-1.0	0.6	-0.7	0.4	-0.6	-1.8	-0.1	-1.9
Leg predicted mass (left)	1.1	5.7	18.5	3.0	3.1	1.5	-2.1	2.2	-1.5	1.7	1.3	-1.4	4.3
Trunk fat mass	0.7	3.2	8.6	2.9	2.6	1.4	-2.1	1.3	0.2	1.9	0.5	0.1	2.1
Waist circumference	1.3	4.8	10.6	3.3	3.1	2.0	-2.3	2.3	0.3	2.4	1.6	0.8	2.1
Number of incorrect matches in round	0.6	0.9	6.7	-0.6	-0.7	-0.3	0.0	-2.6	0.1	-0.4	-0.3	-0.4	-1.2
Past tobacco smoking	1.8	3.3	8.4	-1.2	-1.3	-1.3	0.7	-2.8	-2.9	-0.6	-2.8	-1.8	-1.1
Alcohol usually taken with meals	0.1	0.2	0.6	-0.3	-0.6	-0.5	-0.0	-0.8	0.3	-0.5	0.4	-0.8	0.1
Nervous feelings	0.5	0.9	5.8	0.4	0.6	1.0	0.4	2.4	0.1	0.6	0.4	1.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	1.1	1.0	1.3	-0.2	-0.1	-0.1	0.7	1.1	0.5	0.9
Hearing difficulty/problems with background noise	0.3	0.5	1.7	0.6	0.4	0.3	-1.0	0.0	-0.2	1.3	-1.2	0.2	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.9	-0.1	0.0	-0.3	0.1	-1.0	0.3	0.2	-0.5	-0.1	-0.4
Had menopause	0.8	1.0	2.6	1.1	1.2	1.0	-1.2	0.2	0.6	1.4	0.5	1.6	0.1
Had other major operations	0.2	0.3	1.0	0.2	0.2	-0.3	-0.5	1.0	-0.1	-0.6	0.4	-0.7	0.8
Forced vital capacity (FVC)	0.6	2.4	12.2	1.1	1.4	0.5	-1.1	2.2	-0.4	0.8	0.2	-1.1	3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.3	-0.7	-0.7	0.2	0.8	-0.2	1.1	-0.7	-0.1	1.5	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	0.8	0.8	0.6	-0.6	1.1	-0.2	1.2	-0.0	0.2	0.3
Qualifications: None of the above	0.3	0.7	4.3	-0.4	-0.5	-0.3	0.3	0.7	-0.8	0.7	-0.6	0.0	-2.1
Financial difficulties in last 2 years	0.3	0.4	1.1	0.7	0.4	0.8	-0.7	0.5	1.0	0.9	-0.1	0.5	0.4
Mouth/teeth dental problems	0.5	0.7	4.3	0.1	-0.1	-0.4	-0.0	-0.7	-2.1	-0.1	-0.1	-1.4	-0.3
Heart attack	1.4	1.8	3.7	1.9	1.8	1.8	-1.5	-0.1	-0.2	1.9	1.1	0.8	0.4
Allergy	0.6	1.3	3.9	0.9	1.1	1.1	-0.6	0.4	0.6	0.7	2.0	1.1	1.7
Pain all over the body in last month	2.9	3.1	5.7	-2.4	-2.0	-2.1	2.4	-0.8	-1.8	-1.3	-2.0	-1.2	-0.7
Diabetes (self-reported)	0.5	0.7	2.3	-0.8	-0.6	-0.8	1.5	-0.4	-0.9	-0.9	-0.0	-1.1	-0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.5	0.0	0.1	-0.2	-0.6	-0.4	-0.4	0.2	-1.2	-0.3	-1.0
Medication: Ramipril	1.1	1.5	2.6	1.5	1.6	1.4	-1.0	0.8	-0.2	1.6	0.6	0.8	1.6
Medication: Simvastatin	3.0	4.5	8.8	2.2	2.4	2.5	-1.8	1.5	2.3	3.0	1.8	1.6	1.6
Fluid intelligence score	0.3	0.6	1.1	0.9	0.5	0.8	-1.0	0.7	0.4	1.0	0.5	0.3	-1.1
Illnesses of siblings	1.3	1.8	2.9	-1.5	-1.7	-1.5	0.8	-1.5	-0.4	-1.3	-1.5	-1.4	-1.3
Neuroticism score	0.2	0.4	1.3	0.6	0.7	0.8	0.4	1.2	0.1	0.3	0.6	0.3	0.4
Weight	1.1	5.5	12.0	3.5	3.2	1.8	-2.5	2.2	-0.6	2.1	1.4	-0.4	3.4
Impedance of arm (right)	0.3	1.3	5.1	-1.1	-1.3	-1.4	0.7	-0.8	-0.3	-0.5	-2.3	-0.8	-1.2
Arm fat percentage (right)	0.5	1.9	4.5	2.1	1.9	1.4	-1.4	0.9	1.0	1.7	0.8	1.3	0.6
Trunk fat-free mass	1.4	8.2	25.1	3.6	3.6	1.9	-2.8	2.5	-1.8	2.2	1.8	-1.4	5.0
Hip circumference	1.4	5.9	10.8	3.3	3.2	2.2	-2.6	2.7	1.0	2.2	1.9	1.2	2.9
Time employed in main current job	1.0	1.1	9.2	-0.6	-0.6	-0.6	0.0	-3.0	-0.6	0.2	-0.4	-0.2	-0.4
Alcohol intake versus 10 years previously	0.4	0.5	1.3	-0.2	-0.2	-0.5	0.9	-0.8	-1.0	-0.6	-0.3	-0.8	-1.2
Father’s age at death	0.3	0.4	2.8	-0.2	0.0	-0.3	-0.2	-1.7	0.5	-0.3	0.5	0.3	-0.1
Worrier / anxious feelings	0.1	0.2	0.7	0.6	0.3	0.3	-0.5	-0.1	-0.9	0.5	-0.1	-0.7	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.7	-0.1	-0.3	-0.5	0.3	0.7	-1.3	0.4	-0.8	-1.3	-0.2
Falls in the last year	0.5	0.7	2.9	-0.7	-0.8	-1.0	0.1	-0.7	-0.7	-0.2	-1.7	-0.5	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	2.2	-0.6	-0.6	-0.6	1.0	0.2	-1.5	-0.4	-0.8	-0.6	-0.1
Number of live births	0.3	0.4	1.8	-0.8	-0.6	-0.4	0.5	0.6	-0.4	0.1	-1.4	-0.3	-0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	11.2	0.8	0.9	0.2	-0.5	2.1	-0.9	0.7	-0.0	-1.5	3.3
Pulse rate	2.9	4.9	11.6	-3.0	-2.5	-2.2	3.4	-0.2	-0.7	-3.4	-1.2	-1.6	-0.9
Happiness	1.7	2.1	3.4	1.9	1.7	1.2	-1.8	1.6	0.8	1.2	1.7	1.1	1.1
Noisy workplace	0.1	0.1	0.6	0.3	0.2	-0.3	-0.6	-0.3	-0.1	-0.0	-0.3	-0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.0	-0.1	0.2	0.0	-0.3	-1.0	0.5	-0.1	0.2	0.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.8	1.2	0.9	0.8	-0.4	2.2	1.0	1.0	0.9	0.9	1.5
Mouth/teeth dental problems: Dentures	0.3	0.6	1.4	0.9	1.2	0.9	-1.1	0.3	0.5	1.1	0.2	0.2	-0.1
Asthma	0.5	1.0	4.9	-0.7	-0.9	-0.5	0.4	-1.1	-0.2	0.1	-1.5	-0.4	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.1	-0.4	-0.4	0.0	0.8	-0.4	-0.4	0.6	-0.7	0.1
Medication: Cholesterol lowering	0.8	1.2	3.4	1.3	1.7	1.4	-0.7	-0.1	0.4	1.8	1.0	0.6	0.8
Depression (self-reported)	0.2	0.3	1.4	-0.1	0.1	-0.2	0.3	-0.5	-0.8	0.3	-0.4	-0.4	1.2
Medication: Lansoprazole	0.3	0.4	1.1	-0.4	-0.2	-0.7	0.1	0.2	-0.9	-0.7	-1.0	-1.0	0.2
Prospective memory result	0.6	0.7	1.5	-0.8	-0.8	-0.9	1.1	1.1	-0.5	-1.2	-0.6	-0.4	0.3
Lung cancer (father)	0.2	0.2	0.5	0.4	0.1	0.4	-0.3	-0.6	-0.7	0.1	0.7	-0.7	0.1
Illnesses of mother	1.6	2.0	3.1	-1.4	-1.8	-1.5	1.4	-1.7	-1.1	-1.5	-1.5	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	11.6	0.6	0.5	0.1	-0.2	2.5	-0.7	0.3	0.3	-1.4	3.4
Pulse wave Arterial Stiffness index	1.1	1.3	3.9	-0.7	-0.9	-1.2	0.6	0.7	-2.0	-0.6	-1.2	-1.9	-0.1
Impedance of arm (left)	0.4	1.8	5.7	-1.4	-1.7	-1.6	0.8	-0.8	-0.0	-0.8	-2.4	-0.9	-1.3
Arm fat mass (right)	0.9	3.6	8.4	2.9	2.7	1.8	-2.0	1.7	0.5	2.0	1.3	0.8	2.0
Trunk predicted mass	1.4	8.0	25.1	3.5	3.6	1.9	-2.8	2.5	-1.8	2.1	1.8	-1.4	5.0
Standing height	1.1	10.9	34.7	3.9	3.5	1.1	-3.3	3.0	-3.0	2.3	0.5	-3.3	5.9
Length of working week for main job	1.6	1.8	4.7	-1.6	-1.8	-1.7	1.6	0.4	-0.3	-2.2	-0.2	-1.1	-0.6
Exposure to tobacco smoke at home	3.0	3.3	6.5	-2.0	-1.6	-2.3	1.8	1.1	-1.2	-2.2	-1.4	-1.5	-2.6
Breastfed as a baby	1.1	1.4	2.8	-1.6	-1.7	-1.3	1.2	-1.6	0.0	-1.3	-0.8	-0.2	-0.7
Tense / ‘highly strung’	0.3	0.5	2.2	-0.2	0.1	0.4	1.0	1.0	-0.0	-0.6	1.5	0.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.4	-0.3	-0.1	-0.2	0.6	1.2	-0.5	0.1	-0.6	-0.3	0.3
Hair/balding pattern: Pattern 4	0.6	1.5	3.4	-1.3	-1.4	-1.4	1.3	-0.5	-1.3	-1.8	-0.8	-1.3	-0.4
Birth weight of first child	4.0	7.2	10.0	3.1	3.2	3.1	-2.6	1.8	1.5	2.7	2.7	2.4	3.1
Peak expiratory flow (PEF)	0.5	1.2	7.0	0.9	1.1	0.7	-0.4	1.2	0.3	1.1	0.3	-0.4	2.6
Pulse wave reflection index	0.4	0.4	1.3	0.2	-0.4	-0.3	-0.9	0.1	-0.9	0.3	-0.5	-1.1	-0.9
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	1.0	0.8	0.9	-1.4	1.5	0.2	0.7	0.7	0.8	0.2
Loud music exposure frequency	0.6	0.6	1.5	-0.8	-0.5	-0.5	1.1	-0.9	-0.6	-0.7	-0.6	-0.7	-1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.6	0.2	0.6	0.2	-0.1	0.4	1.2	-0.5	1.1	0.5	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.8	-0.3	-0.5	-0.1	0.4	0.0	1.3	-0.7	0.2	1.1	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.7	0.0	0.0	-0.3	0.6	0.5	0.1	-0.8	0.1	0.1	-0.1
Medication: Paracetamol	0.1	0.2	1.0	0.1	-0.4	-0.3	-0.3	0.3	-0.3	-0.0	-0.8	-1.0	0.2
Headache pain in last month	0.3	0.5	1.9	0.5	0.1	-0.0	-0.6	0.0	-0.5	0.8	-0.1	-1.1	1.4
Medication for cholesterol, blood pressure or diabetes	2.5	4.2	10.2	-2.4	-2.8	-2.3	2.0	-0.7	-0.9	-3.2	-1.5	-1.0	-2.0
Glaucoma (self-reported)	1.7	1.9	7.1	1.6	1.4	1.1	-1.1	1.3	1.1	0.5	1.4	0.6	2.7
Gout (self-reported)	0.5	0.7	2.3	0.9	0.6	0.4	-1.3	0.2	-0.6	1.5	-0.7	-0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-0.6	-0.2	-0.7	0.7	1.3	-1.3	-0.8	-0.6	-1.2	1.0
Medication: Amlodipine	0.5	0.7	3.1	0.2	0.3	0.6	0.2	1.8	0.9	0.7	0.3	0.8	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.3	0.5	0.5	-0.7	1.2	0.4	0.9	-0.3	0.6	0.1
Birth weight	0.9	1.9	3.9	1.7	1.8	1.5	-1.5	0.7	0.6	1.6	1.0	0.5	2.0
Chronic bronchitis/emphysema (mother)	2.0	2.3	3.9	-1.4	-1.6	-1.2	1.5	-1.7	-1.8	0.0	-2.0	-1.1	-2.0
High blood pressure (siblings)	1.0	1.4	2.5	1.5	1.6	1.2	-1.1	1.5	-0.7	1.4	1.1	-0.1	1.2
Forced vital capacity (FVC), Best measure	0.7	2.4	13.0	0.9	0.9	0.4	-0.8	2.7	-0.1	0.5	0.6	-1.0	3.6
Body fat percentage	0.3	1.1	3.3	1.8	1.6	0.8	-1.1	0.6	0.7	1.2	0.2	0.7	0.4
Leg fat percentage (right)	0.5	1.9	3.7	1.9	1.8	1.4	-1.3	0.7	1.5	1.4	1.1	1.7	0.3
Arm fat-free mass (right)	1.2	6.4	19.2	3.2	3.2	1.7	-2.4	2.5	-1.3	1.8	1.6	-1.2	4.4
Exposure to tobacco smoke outside home	0.2	0.3	1.1	0.4	0.4	-0.1	-0.2	1.1	-0.6	-0.6	-0.4	-0.8	0.1
Comparative body size at age 10	0.9	2.5	3.4	1.9	1.6	1.6	-1.7	1.5	1.6	1.2	1.7	1.8	1.0
Number of full brothers	0.2	0.3	0.8	-0.5	-0.5	-0.5	0.2	0.4	-0.9	-0.1	-0.2	-0.8	-0.1
Worry too long after embarrassment	0.1	0.2	0.7	0.4	0.4	0.3	0.1	-0.0	0.2	-0.3	0.8	-0.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.1	4.9	-1.8	-1.4	-1.5	2.2	0.4	-1.7	-1.8	-0.9	-1.3	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	0.4	0.6	0.5	-0.6	1.1	-0.8	1.3	-0.9	-0.3	0.2
Number of children fathered	0.5	0.6	3.9	-0.2	-0.1	-0.5	0.3	-2.0	0.1	-1.1	0.1	0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.9	0.5	0.4	0.5	-0.4	-0.1	1.7	0.8	0.5	1.2	0.6
Age at first live birth	2.7	4.8	8.4	2.0	1.8	2.5	-2.9	1.4	2.5	2.5	1.7	2.4	1.7
Pulse wave peak to peak time	1.5	1.7	3.5	1.2	1.5	1.5	-1.1	-0.4	1.9	1.0	1.5	1.8	0.7
Health satisfaction	0.1	0.1	0.3	-0.0	-0.2	-0.5	0.1	0.2	-0.4	-0.4	0.1	-0.5	-0.2
Shortness of breath walking on level ground	1.1	1.3	2.8	1.7	1.5	1.0	-1.0	-1.4	-1.1	0.8	1.1	0.3	0.9
Qualifications: College or University degree	0.2	0.8	1.6	1.1	1.0	0.9	-1.3	-0.9	0.3	0.7	1.2	0.4	0.4
Eye problems/disorders: None of the above	1.6	1.8	2.8	-1.6	-1.4	-1.7	1.7	-0.6	-1.4	-1.3	-1.1	-1.3	-1.1
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.2	1.0	1.1	1.5	-0.9	1.5	1.8	1.2	1.3	1.8	0.1
Emphysema/chronic bronchitis	0.5	0.5	1.3	-0.7	-0.6	-0.6	0.6	-0.3	-1.1	-0.1	-1.1	-0.7	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.8	-0.4	-0.4	0.7	0.4	-0.4	-0.7	-0.7	0.3	-0.6
Neck or shoulder pain in last month	0.5	0.7	2.2	-0.7	-0.8	-1.1	0.8	0.5	-0.7	-0.6	-1.0	-1.5	-0.2
Medication: Blood pressure	1.9	3.4	9.4	2.5	2.4	2.2	-2.0	0.7	0.3	3.1	1.2	0.5	1.5
Angina (self-reported)	0.1	0.2	0.5	0.1	0.1	0.1	0.0	-0.7	0.4	0.2	-0.4	-0.3	-0.7
Migraine (self-reported)	0.5	0.6	2.1	-0.5	-0.6	-0.9	-0.2	0.0	-1.2	-0.2	-0.7	-1.4	-0.7
Medication: Ibuprofen	0.2	0.2	0.9	0.2	-0.1	-0.3	-0.2	1.0	0.2	-0.3	0.9	-0.3	-0.1
Medication: Allopurinol	0.4	0.5	1.3	0.9	0.7	0.3	-1.1	-0.3	-0.5	1.1	-0.5	-0.6	-0.3
Medication: Omeprazole	0.1	0.1	0.5	0.1	0.3	-0.3	0.1	0.5	0.2	0.3	0.1	-0.5	0.7
Medication: Seretide 50 evohaler	0.1	0.2	0.8	-0.1	-0.3	-0.4	0.3	-0.9	-0.5	-0.2	-0.4	-0.4	0.2
Mean time to correctly identify matches	2.2	4.2	9.1	-2.4	-2.2	-1.7	2.7	-0.9	-1.6	-2.2	-1.3	-1.3	-3.0
Heart disease (mother)	0.4	0.5	1.7	0.6	1.1	0.4	-0.6	1.3	0.5	0.7	0.1	0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	0.5	0.4	0.4	-0.5	-1.3	1.2	0.2	0.3	1.0	-0.9
Whole body fat mass	0.6	2.3	6.5	2.5	2.3	1.2	-1.7	1.2	0.1	1.7	0.6	0.1	1.6
Leg fat mass (right)	0.7	2.6	6.1	2.5	2.3	1.5	-1.7	1.3	0.5	1.6	1.1	0.7	1.6
Arm predicted mass (right)	1.3	6.5	20.0	3.3	3.3	1.9	-2.3	2.3	-1.2	1.8	1.8	-0.9	4.5
Pulse rate, automated reading	0.8	2.7	6.9	-2.4	-1.8	-1.6	2.6	0.9	0.8	-2.3	-0.9	-0.7	-0.6
Alcohol intake frequency.	1.9	4.3	6.4	-2.1	-1.9	-2.5	1.9	0.8	-2.1	-1.8	-2.5	-2.0	-2.5
Comparative height size at age 10	1.0	5.6	15.4	1.8	1.6	-0.5	-1.5	3.9	-2.9	1.0	-0.6	-3.4	3.3
Number of full sisters	0.1	0.2	1.0	0.1	0.1	0.1	0.1	-1.0	0.3	-0.0	-0.3	0.8	-0.2
Suffer from ‘nerves’	0.3	0.4	1.3	0.1	0.3	0.2	0.5	1.2	-0.0	-0.6	1.0	0.3	1.1
Overall health rating	0.3	0.6	1.1	1.0	0.9	0.9	-0.4	0.9	0.1	1.0	0.9	0.2	-0.5
Chest pain or discomfort	0.4	0.6	3.2	0.3	0.2	-0.4	0.3	0.0	-1.8	0.0	-0.4	-1.1	0.8
Had major operations	2.7	3.1	6.6	-1.3	-1.6	-1.5	0.9	-1.5	-2.0	-1.3	-2.6	-2.3	-1.9
Age at last live birth	1.8	2.6	4.8	1.3	1.2	1.7	-2.1	1.6	2.2	1.8	1.0	1.5	1.4
Family relationship satisfaction	0.1	0.1	0.5	-0.1	-0.0	-0.2	-0.1	0.7	0.3	-0.6	0.3	0.1	0.3
Leg pain on walking	0.4	0.5	4.1	0.3	-0.2	-0.0	-0.2	-2.0	-0.1	-0.1	-0.8	0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-1.0	-0.5	-1.1	0.9	-0.2	-0.7	-0.6	-1.4	-1.1	0.9
Commuting to job workplace: Car/motor vehicle	4.1	4.7	6.1	-2.4	-2.5	-2.4	2.4	-1.4	-1.4	-2.4	-2.3	-1.8	-2.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.2	-0.2	-0.2	-0.0	-0.4	-1.1	0.2	-0.5	0.2	-0.0	-0.8
Medication: Aspirin	4.6	6.0	8.9	2.7	2.7	3.0	-2.3	-1.5	1.7	2.9	2.7	2.6	2.0
Supplements: Vitamin C	0.7	0.9	3.9	0.8	0.5	0.6	-1.1	-2.0	-0.7	0.9	-0.5	-0.7	0.5
Knee pain experienced in last month	0.4	0.7	1.8	1.3	1.0	1.1	-0.8	0.2	-0.3	1.3	0.1	0.4	0.5
Hypertension (Self-reported)	1.3	3.7	7.9	2.2	2.6	2.3	-1.6	1.8	0.3	2.8	1.1	0.4	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	5.6	0.1	0.3	-0.6	-0.5	2.4	-0.4	-0.2	-0.4	-1.0	1.0
Illnesses of father: Heart disease	0.3	0.4	3.0	-0.3	-0.0	-0.1	0.4	-1.7	0.2	0.3	-0.7	0.2	0.3
Illnesses of siblings: Diabetes	0.2	0.2	0.8	0.5	0.4	0.1	-0.3	-0.9	-0.4	0.9	-0.2	0.2	-0.3
Smoking status: Previous	0.7	1.1	4.5	0.1	0.2	0.2	0.4	2.1	1.8	-0.4	1.2	1.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.8	1.0	1.0	0.2	-1.0	0.8	-0.5	-0.0	0.2	-1.1	2.2
Whole body fat-free mass	1.3	7.2	23.0	3.4	3.4	1.7	-2.5	2.3	-1.8	1.9	1.6	-1.5	4.8
Leg fat-free mass (right)	1.0	5.1	16.2	2.8	2.8	1.2	-2.0	1.9	-1.8	1.6	1.1	-1.7	4.0
Arm fat percentage (left)	0.5	1.9	4.4	2.1	1.8	1.3	-1.4	1.0	1.3	1.4	0.8	1.4	0.6
Average weekly red wine intake	1.1	1.6	4.1	0.9	0.7	1.2	-1.0	0.7	2.0	1.1	1.4	1.7	1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	-0.7	-0.8	-0.8	0.6	-1.1	-0.5	-0.4	-1.0	-0.7	-0.5
Mood swings	0.1	0.1	0.4	-0.0	0.1	-0.2	0.3	0.6	0.3	-0.3	-0.4	0.4	-0.4
Loneliness, isolation	0.3	0.5	1.2	0.1	0.3	0.7	0.8	1.1	0.1	0.6	1.0	0.7	0.5
Long-standing illness, disability or infirmity	0.8	1.2	3.1	-0.8	-0.5	-1.3	1.0	1.6	-0.8	-0.7	-1.3	-1.8	0.5
Ever had bowel cancer screening	0.0	0.1	0.3	-0.2	0.6	0.1	-0.1	-0.1	0.0	-0.2	0.2	0.2	0.1
Diabetes diagnosed by doctor	0.5	0.9	2.4	-0.8	-0.7	-0.8	1.5	-0.4	-1.2	-0.9	0.1	-1.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.5	-0.8	-0.7	-0.3	0.8	-0.3	0.4	-1.2	-0.3	0.2	-0.2
Friendships satisfaction	1.0	1.3	2.7	1.3	1.1	1.2	-1.2	1.6	0.7	1.1	1.1	1.1	0.5
Qualifications: nursing, teaching	0.5	0.8	3.8	0.2	0.5	-0.0	-0.3	0.9	1.5	-0.6	0.5	0.4	2.0
Commuting to job workplace: Walk	2.4	2.6	5.2	1.3	1.7	2.0	-1.4	0.1	1.2	1.5	2.2	2.3	1.4
Eye problems/disorders: Cataract	2.5	2.9	6.3	1.5	1.5	2.2	-1.8	0.8	2.3	1.2	1.8	2.5	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.6	-0.6	-0.6	-0.1	0.2	-1.3	1.1	-0.5	-0.3	0.5	-0.2
Medication for cholesterol	0.8	1.2	4.8	-0.8	-1.4	-1.0	0.4	-1.4	-0.0	-1.0	-0.5	0.4	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	5.3	-2.2	-2.3	-2.3	1.8	-2.1	-1.2	-2.2	-2.0	-1.9	-1.5
Back pain experienced in last month	0.8	1.1	2.7	-0.8	-1.4	-1.2	0.8	-0.0	-1.2	-0.7	-1.3	-1.6	0.3
Mineral and other dietary supplements	0.4	0.5	1.3	-0.0	-0.2	-0.1	0.3	1.2	1.1	-0.6	1.0	0.5	0.8
Breast cancer (self-reported)	0.1	0.1	0.4	0.3	0.1	0.3	-0.6	0.5	-0.1	0.4	-0.2	-0.3	0.1
Asthma (self-reported)	0.6	1.3	4.7	-0.8	-1.1	-0.8	0.5	-1.3	-0.7	-0.1	-1.7	-0.7	-2.2
Osteoporosis (self-reported)	0.6	0.7	1.4	-0.8	-0.9	-1.0	0.5	-1.0	-0.3	-0.7	-0.7	-0.9	-1.2
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.7	0.5	0.4	-0.7	-0.4	-0.8	0.6	-0.2	-0.5	-0.4
Medication: Aspirin	5.1	6.7	9.6	2.8	2.8	3.1	-2.4	-1.0	2.3	3.0	3.0	2.8	1.8
Medication: Gliclazide	0.5	0.6	1.5	0.1	0.1	0.7	0.4	1.1	0.7	0.3	1.0	1.2	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.6	-0.9	-0.5	0.5	1.2	-0.3	-1.2	0.3	-0.4	0.5
Smoking status: Current	1.8	2.9	6.9	1.8	1.8	1.9	-1.4	0.6	1.3	1.7	2.6	1.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.1	-1.0	-0.8	-0.6	0.9	0.8	-0.3	0.1	-1.4	-0.4	0.4
Whole body water mass	1.3	7.7	23.9	3.5	3.5	1.8	-2.6	2.4	-1.8	2.1	1.7	-1.4	4.9
Leg predicted mass (right)	0.9	4.9	15.7	2.8	2.7	1.2	-2.0	1.8	-1.8	1.6	1.1	-1.7	4.0
Arm fat mass (left)	0.6	2.5	5.9	2.4	2.3	1.4	-1.6	1.4	0.3	1.6	0.9	0.5	1.8
Number of self-reported non-cancer illnesses	0.4	0.7	2.5	1.0	1.0	0.5	-1.0	0.6	-0.5	1.6	0.1	-0.8	-0.3
Average weekly champagne plus white wine intake	0.4	0.5	1.9	0.2	0.6	0.4	0.1	-1.1	0.3	0.9	0.6	0.3	1.4
Miserableness	0.4	0.7	1.4	1.1	1.0	0.6	-0.5	1.2	0.7	0.8	0.9	0.5	0.7
Guilty feelings	0.2	0.3	1.4	0.4	0.4	0.5	0.3	1.2	-0.5	0.4	0.6	-0.4	0.3
Wears glasses or contact lenses	0.0	0.0	0.1	-0.1	0.3	0.1	0.2	-0.0	0.1	0.2	0.2	-0.1	-0.2
Ever taken oral contraceptive pill	0.7	0.7	2.9	0.4	0.7	1.0	-0.3	-1.7	0.3	0.5	0.9	1.1	0.6
Hearing aid user	1.4	1.6	3.3	1.7	1.6	1.6	-1.7	0.5	0.9	1.8	0.7	0.4	0.3
Mother’s age at death	1.1	1.4	3.2	1.2	1.3	1.1	-1.1	-0.1	1.3	1.0	1.4	1.8	0.8
Financial situation satisfaction	0.7	0.9	3.3	0.4	0.4	0.2	-1.4	1.8	1.2	1.0	-0.2	0.7	0.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.0	0.5	0.7	1.1	-0.8	-0.2	1.8	1.3	0.1	2.0	0.8
Commuting to job workplace: Public transport	1.6	1.9	3.7	1.1	1.2	1.3	-1.2	1.9	1.2	1.4	1.4	1.0	1.9
Eye problems/disorders: Glaucoma	0.1	0.1	0.8	0.3	0.1	0.1	0.3	-0.2	-0.3	-0.1	0.1	-0.5	0.9
Medication: Blood pressure	1.5	2.9	4.9	1.8	2.2	1.8	-1.4	1.6	0.5	1.9	1.7	1.1	2.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	1.0	0.7	1.0	-0.9	0.7	1.4	1.2	0.4	0.5	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.1	-0.3	-0.3	-0.2	0.3	-1.4	-1.0	0.5	-1.4	-0.3	-0.8
High cholesterol (Self-reported)	0.8	1.4	4.0	0.7	1.1	1.4	-0.8	0.3	1.2	2.0	0.8	1.2	1.4
Medication: Bendroflumethiazide	3.0	4.6	7.5	2.5	2.7	2.3	-2.1	0.9	1.5	2.2	2.2	1.7	2.6
Medication: Paracetamol	0.2	0.4	1.4	0.7	0.1	0.2	-0.9	1.2	-0.0	0.6	-0.2	-0.6	0.0
Medication: Lisinopril	1.6	2.0	3.9	1.9	2.0	1.6	-1.8	0.8	-0.3	2.0	1.2	-0.3	1.1
Medication: Atorvastatin	0.7	0.8	1.7	-1.1	-0.3	-1.0	1.0	-0.5	-1.2	-0.8	-1.3	-0.8	-0.3
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.8	1.1	0.8	-0.6	0.4	0.0	0.5	1.1	-0.1	0.5
Alcohol drinker status: Never	0.4	0.5	2.3	0.6	0.4	0.3	-1.2	1.5	0.4	0.7	-0.0	0.3	0.2
Ever smoked	2.4	4.3	10.9	1.4	1.5	1.6	-0.9	2.4	3.3	0.7	3.3	2.3	1.4
Basal metabolic rate	1.2	6.9	20.5	3.4	3.4	1.7	-2.5	2.3	-1.6	2.0	1.5	-1.3	4.5
Leg fat percentage (left)	0.5	1.7	3.7	1.9	1.7	1.3	-1.3	0.5	1.4	1.3	0.9	1.5	0.1
Arm fat-free mass (left)	1.2	6.2	16.3	3.3	3.3	1.7	-2.5	2.1	-1.5	2.0	1.6	-1.1	4.0
Number of operations (self-reported)	2.1	3.1	8.9	-1.4	-1.5	-1.9	1.1	-1.3	-1.7	-1.5	-2.3	-3.0	-1.0
Average weekly beer plus cider intake	1.0	1.4	3.5	1.2	1.4	0.8	-1.3	1.9	0.9	1.2	0.9	1.0	1.1
Irritability	0.1	0.1	0.4	-0.1	0.1	-0.0	0.6	0.6	0.4	-0.2	0.1	0.1	0.0
Risk taking	0.7	1.0	3.1	1.0	1.0	1.0	-0.5	-0.3	1.1	0.3	1.5	0.7	1.8
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.6	0.0	-0.2	0.2	-0.1	0.1	0.5	0.5	0.1	0.8	-0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.7	-0.1	-0.1	0.1	0.4	0.8	-0.2	-0.1	0.4	0.1	-0.2
Age started oral contraceptive pill	0.6	0.7	1.5	0.9	0.9	0.9	-1.2	-0.0	-0.1	1.2	0.4	1.2	-0.8
Diastolic blood pressure, automated reading	1.1	3.5	6.7	2.6	2.6	1.9	-1.8	0.4	0.6	1.8	2.1	0.4	2.6
Ever depressed for a whole week	2.5	3.1	4.4	2.0	2.1	1.5	-1.9	1.2	1.3	1.7	1.9	2.1	1.7
Unable to work because of sickness or disability	3.2	4.2	10.0	-2.0	-2.1	-2.2	2.2	-1.5	-3.2	-1.4	-1.7	-2.1	-1.4
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.7	0.6	1.0	-1.1	-0.9	-0.8	0.5	0.3	-0.2	-0.5
Myopia	0.5	0.7	1.9	0.8	0.7	0.7	-0.6	0.9	1.1	0.8	0.4	0.5	1.4
Vascular/heart problems diagnosed by doctor	1.6	4.3	8.2	-2.4	-2.7	-2.6	1.6	-1.6	-0.7	-2.9	-1.6	-0.8	-2.3
Cholesterol lowering medication	0.9	1.3	2.6	0.5	0.9	1.2	-0.5	1.6	1.5	1.1	0.9	1.2	1.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	2.1	0.2	0.3	-0.2	0.1	1.4	0.5	0.2	0.1	-0.2	0.4
Pain experienced in last month	0.9	1.5	4.3	0.9	1.1	1.3	-1.0	1.0	1.6	0.3	1.3	2.1	0.7
Supplements: Calcium	0.2	0.2	0.4	0.5	0.3	0.3	-0.5	0.3	-0.5	0.7	0.0	-0.3	0.4
Basal cell carcinoma (self-reported)	1.7	2.0	4.5	-1.0	-1.2	-1.3	1.4	-1.8	-2.1	-1.0	-1.4	-1.6	-0.9
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.2	1.8	1.6	1.8	-1.4	-0.2	-0.2	1.8	1.0	0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	0.2	0.1	-0.2	0.4	0.3	-0.1	-0.7	0.1	0.2	-0.1
Heart disease (siblings)	0.4	0.4	1.7	0.3	0.7	0.7	-0.1	0.7	0.4	0.5	0.5	1.3	0.6
Alcohol drinker status: Previous	1.0	1.2	2.5	-1.2	-1.0	-1.4	1.6	0.7	-1.3	-1.0	-1.0	-0.5	-0.6
Pack years of smoking	0.6	0.9	2.2	1.4	1.5	1.0	-1.0	-0.9	0.1	1.1	0.6	0.5	0.8
Impedance of whole body	0.3	1.5	5.0	-1.2	-1.5	-1.3	0.6	-1.0	0.4	-0.7	-2.2	-0.5	-1.6
Leg fat mass (left)	0.6	2.3	6.0	2.4	2.2	1.4	-1.7	1.2	0.4	1.6	1.0	0.5	1.5
Arm predicted mass (left)	1.4	7.1	20.7	3.5	3.5	1.9	-2.6	2.2	-1.3	2.2	1.8	-0.8	4.5