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chr15:40,360,741-42,820,589

Best TWAS P=4.9e-15 · Best GWAS P=1.44e-13 conditioned to 0.458

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	7.4	-7.8	4.9e-15	-0.90	0.02	0.97	TRUE
8	GTEx	Colon Sigmoid	NDUFAF1	0.15	0.06	lasso	4	0.06	5.2e-03	6.3	-7.2	6.9e-13	-0.70	0.14	0.65	FALSE
18	YFS	Blood	MGA	0.01	0.00	blup	454	0.00	7.1e-02	6.3	7.1	9.7e-13	0.69	0.02	0.81	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXD1	0.04	0.04	lasso	3	0.04	8.1e-06	7.3	-7.0	1.9e-12	-0.94	0.02	0.98	FALSE
11	GTEx	Lung	OIP5-AS1	0.09	0.08	enet	14	0.12	2.8e-09	7.4	6.8	7.6e-12	0.88	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHP	0.01	0.01	blup	54	0.01	1.4e-02	7.3	-6.8	7.8e-12	-0.92	0.01	0.90	FALSE
17	NTR	Blood	INO80	0.02	0.02	enet	8	0.03	2.8e-09	6.8	-6.6	3.5e-11	-0.84	0.18	0.82	FALSE
10	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	6.1	-6.6	3.8e-11	-0.94	0.02	0.98	FALSE
5	GTEx	Brain Cortex	GCHFR	0.25	0.04	enet	15	0.05	1.4e-02	6.6	-6.5	6.2e-11	-0.77	0.04	0.70	FALSE
9	GTEx	Esophagus Mucosa	NDUFAF1	0.25	0.18	enet	26	0.24	4.3e-16	6.3	-6.3	2.8e-10	-0.60	0.97	0.03	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	INO80	0.03	0.02	blup	39	0.03	1.0e-03	3.3	6.2	4.8e-10	0.78	0.05	0.87	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	NDUFAF1	0.16	0.06	lasso	3	0.07	1.7e-04	6.3	-6.2	7.1e-10	-0.50	0.09	0.12	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INO80	0.07	0.04	blup	40	0.06	1.2e-03	4.2	6.1	1.3e-09	0.80	0.03	0.69	FALSE
4	GTEx	Artery Aorta	OIP5-AS1	0.16	0.21	enet	26	0.23	5.2e-13	5.0	5.9	4.2e-09	0.74	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INO80	0.03	0.02	blup	38	0.03	1.1e-02	3.2	5.7	1.3e-08	0.72	0.03	0.34	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPAP1	0.04	0.00	blup	56	0.03	1.4e-02	6.3	-5.7	1.4e-08	-0.36	0.01	0.80	FALSE
12	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	3.6	5.6	2.2e-08	0.80	0.40	0.60	FALSE
16	GTEx	Thyroid	OIP5-AS1	0.20	0.19	lasso	8	0.20	4.1e-15	5.0	5.5	3.2e-08	0.70	1.00	0.00	FALSE
7	GTEx	Breast Mammary Tissue (Female)	OIP5-AS1	0.28	0.31	lasso	3	0.29	3.0e-09	5.0	5.5	3.8e-08	0.72	0.77	0.22	FALSE
3	GTEx	Adipose Visceral Omentum	OIP5-AS1	0.23	0.16	lasso	10	0.11	2.8e-06	4.1	5.5	4.9e-08	0.64	0.94	0.06	FALSE
6	GTEx	Breast Mammary Tissue	OIP5-AS1	0.20	0.24	lasso	7	0.22	1.8e-11	5.0	5.4	7.0e-08	0.69	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	RTF1	0.04	0.02	lasso	3	0.02	4.0e-03	-5.1	-5.3	9.8e-08	-0.73	0.10	0.29	FALSE
15	GTEx	Thyroid	PLA2G4B	0.14	0.09	enet	11	0.08	1.6e-06	3.9	5.3	1.3e-07	0.05	0.98	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NDUFAF1	0.14	0.16	bslmm	304	0.19	6.6e-23	5.2	-5.2	2.5e-07	-0.48	1.00	0.00	FALSE