Best TWAS P=4.9e-15 · Best GWAS P=1.44e-13 conditioned to 0.458
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EXD1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 8.1e-06 | 7.3 | -7.0 | 1.9e-12 | -0.94 | 0.02 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NDUFAF1 | 0.14 | 0.16 | bslmm | 304 | 0.19 | 6.6e-23 | 5.2 | -5.2 | 2.5e-07 | -0.48 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | OIP5-AS1 | 0.23 | 0.16 | lasso | 10 | 0.11 | 2.8e-06 | 4.1 | 5.5 | 4.9e-08 | 0.64 | 0.94 | 0.06 | FALSE |
| 4 | GTEx | Artery Aorta | OIP5-AS1 | 0.16 | 0.21 | enet | 26 | 0.23 | 5.2e-13 | 5.0 | 5.9 | 4.2e-09 | 0.74 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cortex | GCHFR | 0.25 | 0.04 | enet | 15 | 0.05 | 1.4e-02 | 6.6 | -6.5 | 6.2e-11 | -0.77 | 0.04 | 0.70 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | OIP5-AS1 | 0.20 | 0.24 | lasso | 7 | 0.22 | 1.8e-11 | 5.0 | 5.4 | 7.0e-08 | 0.69 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | OIP5-AS1 | 0.28 | 0.31 | lasso | 3 | 0.29 | 3.0e-09 | 5.0 | 5.5 | 3.8e-08 | 0.72 | 0.77 | 0.22 | FALSE |
| 8 | GTEx | Colon Sigmoid | NDUFAF1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 5.2e-03 | 6.3 | -7.2 | 6.9e-13 | -0.70 | 0.14 | 0.65 | FALSE |
| 9 | GTEx | Esophagus Mucosa | NDUFAF1 | 0.25 | 0.18 | enet | 26 | 0.24 | 4.3e-16 | 6.3 | -6.3 | 2.8e-10 | -0.60 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Esophagus Mucosa | CHP1 | 0.19 | 0.10 | lasso | 7 | 0.09 | 1.4e-06 | 6.1 | -6.6 | 3.8e-11 | -0.94 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Lung | OIP5-AS1 | 0.09 | 0.08 | enet | 14 | 0.12 | 2.8e-09 | 7.4 | 6.8 | 7.6e-12 | 0.88 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Nerve Tibial | NUSAP1 | 0.15 | 0.09 | enet | 10 | 0.15 | 9.8e-11 | 3.6 | 5.6 | 2.2e-08 | 0.80 | 0.40 | 0.60 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | NDUFAF1 | 0.16 | 0.06 | lasso | 3 | 0.07 | 1.7e-04 | 6.3 | -6.2 | 7.1e-10 | -0.50 | 0.09 | 0.12 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | CHP1 | 0.06 | 0.04 | enet | 9 | 0.04 | 3.1e-04 | 7.4 | -7.8 | 4.9e-15 | -0.90 | 0.02 | 0.97 | TRUE |
| 15 | GTEx | Thyroid | PLA2G4B | 0.14 | 0.09 | enet | 11 | 0.08 | 1.6e-06 | 3.9 | 5.3 | 1.3e-07 | 0.05 | 0.98 | 0.01 | FALSE |
| 16 | GTEx | Thyroid | OIP5-AS1 | 0.20 | 0.19 | lasso | 8 | 0.20 | 4.1e-15 | 5.0 | 5.5 | 3.2e-08 | 0.70 | 1.00 | 0.00 | FALSE |
| 17 | NTR | Blood | INO80 | 0.02 | 0.02 | enet | 8 | 0.03 | 2.8e-09 | 6.8 | -6.6 | 3.5e-11 | -0.84 | 0.18 | 0.82 | FALSE |
| 18 | YFS | Blood | MGA | 0.01 | 0.00 | blup | 454 | 0.00 | 7.1e-02 | 6.3 | 7.1 | 9.7e-13 | 0.69 | 0.02 | 0.81 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHP | 0.01 | 0.01 | blup | 54 | 0.01 | 1.4e-02 | 7.3 | -6.8 | 7.8e-12 | -0.92 | 0.01 | 0.90 | FALSE |
| 20 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RPAP1 | 0.04 | 0.00 | blup | 56 | 0.03 | 1.4e-02 | 6.3 | -5.7 | 1.4e-08 | -0.36 | 0.01 | 0.80 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INO80 | 0.03 | 0.02 | blup | 38 | 0.03 | 1.1e-02 | 3.2 | 5.7 | 1.3e-08 | 0.72 | 0.03 | 0.34 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | INO80 | 0.07 | 0.04 | blup | 40 | 0.06 | 1.2e-03 | 4.2 | 6.1 | 1.3e-09 | 0.80 | 0.03 | 0.69 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | INO80 | 0.03 | 0.02 | blup | 39 | 0.03 | 1.0e-03 | 3.3 | 6.2 | 4.8e-10 | 0.78 | 0.05 | 0.87 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | RTF1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.0e-03 | -5.1 | -5.3 | 9.8e-08 | -0.73 | 0.10 | 0.29 | FALSE |