Hub : Genes

NDUFAF7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.406 0.1030 3.9e-04 0.049 NA 0.053 NA 0.118 1.4e-02 NA 1.1e-02 NA 2.4e-04
2 GTEx Testis 0.447 0.0650 1.9e-13 0.404 NA 0.461 NA 0.463 3.1e-19 NA 1.2e-22 NA 8.9e-23
3 ROSMAP Brain Pre-frontal Cortex 0.128 0.0343 5.9e-07 0.071 0.075 0.097 0.09 0.078 1.7e-09 6.3e-10 1.7e-12 1.1e-11 2.9e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.1 3.3 4.8 -2.2 1.9 -1.3
Bipolar Disorder or Schizophrenia 4.3 10.5 17.1 -4.1 3.6 -1.3
Depressed Affect (Nagel 2018) 0.3 0.6 1.7 -0.1 -0.3 -1.3
Depression (Nagel 2018) 0.7 1.0 2.1 0.3 -0.8 -1.5
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.0 0.0 -0.2 -1.4
Neuroticism (Nagel 2018) 0.5 1.1 2.0 1.4 -1.1 0.4
Schizophrenia (2018) 3.5 7.3 12.7 -3.6 3.0 -0.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.5 -0.2 0.0
Worry (Nagel 2018) 0.2 0.5 1.2 1.1 -0.0 0.5
Alzheimer’s Disease (in mother) 1.6 1.8 5.0 0.6 -2.2 0.5
Alzheimer’s Disease (in father) 0.8 0.9 1.5 0.2 -1.2 -1.1
Alzheimer’s Disease (including proxy) 2.1 3.0 6.4 -0.0 -2.5 -1.6
Crohns Disease (2017) 0.3 0.7 1.3 -0.5 1.1 0.7
Irritable Bowel Disease (IBD) 2.2 5.2 8.5 -2.6 2.9 -0.7
Ulcerative Colitis (UC) 4.0 7.6 12.0 -3.1 3.5 -0.9
Major Depression (MDD) 1.3 1.6 3.9 0.1 0.9 2.0
Reaction Time 0.4 0.7 1.0 -0.5 1.0 -0.9
Verbal and Numeric Reasoning (VNR) 0.9 2.1 2.6 1.4 -1.6 -1.3
Breast Cancer 0.3 0.7 1.1 1.0 0.1 1.1
Ovarian Cancer 2.3 3.0 5.1 1.9 -2.3 0.6
Prostate Cancer 0.7 0.9 1.4 1.2 -0.8 -0.8
Age at First Birth 0.8 1.1 2.9 -0.7 1.7 -0.1
Bipolar Disorder (2011) 3.1 3.0 6.2 -2.5 1.6 -0.3
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 0.2 -0.6 -1.3
Coronary Artery Disease (CAD) 0.4 0.5 1.1 -1.1 0.4 -0.6
Crohns Disease (2012) 0.3 0.5 0.6 0.6 0.7 0.7
Mean Putamen Volume 0.6 0.7 1.9 0.2 -0.1 -1.4
Fasting Glucose 2.8 3.3 8.7 0.7 -0.8 3.0
HbA1C 0.3 0.4 0.7 0.5 -0.3 -0.9
HDL Cholesterol 0.9 1.5 3.9 -0.5 2.0 0.6
LDL Cholesterol 0.2 0.4 0.9 -0.1 -0.3 -1.0
Lupus 0.2 0.3 0.6 0.8 -0.0 -0.5
Neuroticism (2016) 1.3 1.9 4.2 2.0 -1.1 0.4
Primary Biliary Cirrhosis 0.4 0.6 1.4 1.2 0.3 0.5
Rheumatoid Arthritis 0.9 1.3 1.8 1.1 -1.4 0.9
Schizophrenia (2014) 4.2 9.3 15.8 -4.0 3.5 -0.3
Triglycerides 0.1 0.2 0.6 -0.1 -0.8 -0.2
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.6 -0.2 -0.3 -1.9
Ulcerative Colitis 5.3 7.7 12.0 -3.5 3.1 -1.1
Blood Eosinophil Count 0.5 3.7 8.4 -0.7 1.5 2.9
Blood Platelet Count 0.3 3.2 6.1 -1.9 2.5 -0.3
Blood Red Count 0.6 5.9 11.6 -3.4 2.0 -1.5
Blood White Count 1.1 7.9 13.2 -3.6 2.8 -1.7
Heel T-Score 1.5 11.8 14.8 -3.2 3.9 -3.3
BMI 0.3 1.9 4.5 -0.2 -1.1 -2.1
Height 0.7 13.7 36.8 -0.9 1.9 6.1
Waist Hip Ratio (WHR) 0.6 2.9 4.2 -2.0 0.8 -2.0
Systolic Blood Pressure 1.8 9.0 21.6 1.0 2.1 4.7
Smoking Status 0.5 1.3 2.7 -0.9 -0.5 -1.7
Allergy or Eczema 0.2 0.7 1.7 1.3 -0.5 0.3
Cardiovascular Disease 1.2 4.0 10.4 0.7 1.1 3.2
Hypothyroidism (self reported) 0.3 0.6 1.4 -0.7 0.1 -1.2
Respiratory disease 0.0 0.1 0.2 0.4 0.0 0.4
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 0.1 -0.1 -0.8
Lung FEV1/FVC ratio 0.8 4.0 5.5 1.3 -2.4 -2.2
Lung FVC 0.2 1.2 2.5 -1.6 0.6 -0.8
Neuroticism 0.7 1.7 3.0 1.7 -1.1 0.9
Chronotype (morning person) 0.7 1.7 2.1 1.1 -1.4 1.4
Hair Pigment 0.2 4.3 8.1 2.8 -1.7 1.4
Tanning 0.2 2.9 6.2 -1.3 2.5 -0.7
Hand grip strength (left) 0.3 0.7 1.3 -1.1 -0.4 0.9
Number of treatments/medications taken 0.1 0.2 0.6 -0.0 0.8 -0.1
Average weekly spirits intake 1.9 2.3 5.9 -2.4 0.6 -0.8
Sensitivity / hurt feelings 0.5 0.8 1.0 1.0 -0.8 0.9
Frequency of depressed mood in last 2 weeks 1.2 1.6 2.4 0.8 -1.4 -1.5
Hearing difficulty/problems: Yes 2.2 3.4 6.7 1.7 -2.6 0.7
Relative age of first facial hair 0.1 0.2 0.6 -0.2 0.7 0.3
Other serious medical condition/disability diagnosed by doctor 2.6 3.4 5.2 -2.3 2.0 -1.0
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.2 -0.6 0.0 -1.5
Ever had hysterectomy (womb removed) 0.6 0.7 1.6 0.1 -1.3 0.6
Systolic blood pressure, automated reading 1.9 5.4 11.2 2.2 0.1 3.3
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 4.4 0.8 -2.1 -0.4
Angina 0.4 0.5 0.6 0.8 0.6 0.8
Medication for hormone replacement therapy 4.5 5.0 7.5 -2.4 2.7 -1.2
Vitamin and mineral supplements 0.1 0.2 0.4 -0.3 -0.6 0.3
Supplements: Zinc 0.8 0.9 1.6 1.0 1.3 -0.1
Medication: Co-codamol 0.2 0.2 0.5 0.4 -0.1 0.7
Medication: Metformin 0.1 0.1 0.3 0.5 -0.3 0.1
Diabetes (father) 0.8 1.0 1.7 1.0 -1.3 -0.4
Diabetes (mother) 0.5 0.6 1.6 1.3 -0.1 0.5
Severe depression (siblings) 2.0 2.2 5.5 0.1 1.1 -2.3
Pack years adult smoking proportion 0.5 0.8 1.4 -1.0 1.2 -0.4
Impedance of leg (right) 1.0 4.9 7.7 -2.2 2.8 1.4
Leg fat-free mass (left) 0.1 0.4 1.1 0.3 -1.1 0.1
Trunk fat percentage 0.0 0.1 0.2 -0.4 0.3 0.2
Hand grip strength (right) 0.6 1.5 2.1 -0.9 -1.3 1.4
Townsend deprivation index at recruitment 0.3 0.5 1.2 1.1 -0.5 -0.0
Current tobacco smoking 0.4 0.7 1.3 0.2 -0.9 -1.2
Average weekly fortified wine intake 1.0 1.2 2.4 0.6 -0.9 1.6
Maternal smoking around birth 0.2 0.3 0.7 0.8 -0.3 -0.5
Fed-up feelings 1.0 1.9 4.0 -2.0 0.4 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 4.1 1.1 -2.0 -1.7
Relative age voice broke 0.3 0.4 1.1 0.3 1.1 -0.2
Taking other prescription medications 0.2 0.3 1.0 0.0 0.2 -1.0
Age when periods started (menarche) 0.0 0.1 0.3 0.2 0.5 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.4 -0.6 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 -0.7 0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -1.0 0.5 -0.1
Qualifications: CSEs or equivalent 1.0 1.3 1.9 -0.8 1.4 -1.2
Serious illness, injury or assault to yourself 1.6 2.0 4.2 -2.1 0.7 -1.1
High blood pressure 3.0 8.3 18.3 0.5 2.5 4.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.6 1.3 -0.2 -0.8
Multivitamins +/- minerals 0.6 0.8 1.5 0.9 -0.3 -1.2
Stomach or abdominal pain in last month 0.8 1.0 1.6 1.2 -1.3 -0.2
Supplements: Glucosamine 0.3 0.4 0.5 -0.2 -0.7 -0.7
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.0 0.6 0.2
Medication: Atenolol 2.1 2.7 7.8 -0.2 2.8 0.4
Medication: Levothyroxine sodium 0.6 1.0 2.7 -1.6 -0.2 -0.5
Sitting height 0.2 1.5 4.2 0.2 -0.6 2.0
Chronic bronchitis/emphysema (father) 1.8 2.1 2.8 1.7 -1.0 1.5
High blood pressure (mother) 0.8 1.1 1.6 0.0 1.3 1.3
Body mass index (BMI) 0.6 2.7 5.6 0.5 -1.6 -2.4
Impedance of leg (left) 1.2 5.6 7.8 -2.3 2.8 1.9
Leg predicted mass (left) 0.1 0.4 1.1 0.4 -1.0 0.1
Trunk fat mass 0.0 0.0 0.1 -0.3 -0.1 -0.0
Waist circumference 0.5 2.0 5.3 0.1 -0.9 -2.3
Number of incorrect matches in round 1.3 2.2 5.2 -1.2 2.3 0.4
Past tobacco smoking 1.6 2.9 3.3 1.8 -1.7 1.6
Alcohol usually taken with meals 0.3 0.5 0.6 0.8 -0.5 0.7
Nervous feelings 1.5 2.8 6.6 2.6 -1.3 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 2.8 1.7 -1.5 0.0
Hearing difficulty/problems with background noise 3.0 4.9 7.2 2.7 -2.7 0.5
Hair/balding pattern: Pattern 2 0.6 0.7 2.0 0.2 0.3 -1.4
Had menopause 0.1 0.1 0.2 0.4 -0.5 -0.2
Had other major operations 0.4 0.5 0.6 -0.7 0.8 -0.5
Forced vital capacity (FVC) 0.1 0.3 0.8 -0.9 0.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.3 -0.8 1.0 -1.1
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 3.0 0.2 -0.8 1.7
Qualifications: None of the above 0.5 1.0 1.8 -1.4 0.8 -0.8
Financial difficulties in last 2 years 0.8 1.1 2.9 0.3 -0.7 -1.7
Mouth/teeth dental problems 1.3 2.0 4.5 -2.1 1.3 0.2
Heart attack 1.5 1.9 4.3 0.7 2.1 1.0
Allergy 0.2 0.4 1.1 -1.1 0.0 -0.2
Pain all over the body in last month 0.5 0.5 1.1 -0.6 1.1 0.2
Diabetes (self-reported) 0.2 0.2 0.7 0.1 -0.1 -0.8
Hayfever/allergic rhinitis (self-reported) 3.3 4.4 8.8 3.0 -1.6 1.3
Medication: Ramipril 0.1 0.1 0.4 0.0 0.7 -0.0
Medication: Simvastatin 0.1 0.1 0.2 -0.4 -0.3 -0.2
Fluid intelligence score 0.3 0.6 1.3 0.1 -1.1 -0.8
Illnesses of siblings 0.2 0.3 0.8 -0.9 0.1 0.1
Neuroticism score 0.7 1.5 2.3 1.5 -1.0 1.1
Weight 0.1 0.5 1.5 0.3 -1.2 -0.3
Impedance of arm (right) 1.3 6.0 14.4 -0.3 1.9 3.8
Arm fat percentage (right) 0.2 0.8 1.3 0.6 -1.2 -0.9
Trunk fat-free mass 0.1 0.8 2.1 0.5 -1.4 0.1
Hip circumference 0.2 0.7 1.2 0.8 -1.1 -0.6
Time employed in main current job 0.4 0.5 1.3 -0.1 1.1 0.1
Alcohol intake versus 10 years previously 0.4 0.6 1.0 -1.0 0.8 0.2
Father’s age at death 1.1 1.4 2.1 0.8 -1.4 1.3
Worrier / anxious feelings 0.0 0.1 0.1 0.4 -0.3 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.0 -0.0 -1.4 -0.3
Falls in the last year 1.3 1.8 2.8 1.7 -1.1 1.1
Hair/balding pattern: Pattern 3 0.5 0.8 1.6 0.8 -1.2 0.4
Number of live births 1.8 2.6 5.6 2.4 -0.2 1.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.4 -0.6 -0.7 -0.5
Pulse rate 0.1 0.2 0.3 -0.3 0.3 -0.5
Happiness 0.2 0.3 0.5 0.3 0.4 -0.7
Noisy workplace 0.3 0.4 0.9 1.0 -0.6 0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.4 0.6 0.7 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.3 0.0 -0.7 1.1
Mouth/teeth dental problems: Dentures 1.5 2.5 6.1 2.5 -1.0 0.6
Asthma 0.4 0.7 1.1 1.1 -0.5 0.9
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.6 3.1 1.8 -1.7 -1.4
Medication: Cholesterol lowering 2.3 3.5 5.3 -2.3 2.0 -1.1
Depression (self-reported) 0.5 0.6 0.7 0.8 -0.8 -0.8
Medication: Lansoprazole 1.4 1.6 3.1 -1.3 0.4 -1.8
Prospective memory result 4.6 5.7 11.4 -2.2 3.4 -0.9
Lung cancer (father) 1.2 1.4 1.8 1.0 -1.2 -1.4
Illnesses of mother 2.0 2.5 3.6 1.6 -1.9 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.5 0.2 -0.3 -0.7
Pulse wave Arterial Stiffness index 0.4 0.4 0.8 0.4 -0.5 0.9
Impedance of arm (left) 1.5 6.8 16.7 0.1 1.9 4.1
Arm fat mass (right) 0.3 1.0 1.8 0.3 -1.4 -1.1
Trunk predicted mass 0.1 0.8 2.1 0.5 -1.5 -0.0
Standing height 0.6 6.1 17.6 -0.5 0.6 4.2
Length of working week for main job 3.7 4.1 8.7 -3.0 0.8 -1.7
Exposure to tobacco smoke at home 0.8 0.9 0.9 -0.9 0.9 1.0
Breastfed as a baby 0.4 0.5 1.1 -0.6 0.2 1.1
Tense / ‘highly strung’ 0.2 0.3 0.6 0.8 0.5 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.9 -0.1 -0.9 -2.0
Hair/balding pattern: Pattern 4 0.5 1.2 1.6 1.2 -1.3 0.7
Birth weight of first child 0.6 1.0 3.0 -1.7 0.1 0.1
Peak expiratory flow (PEF) 0.1 0.2 0.3 0.5 -0.3 -0.4
Pulse wave reflection index 1.7 2.1 3.8 0.4 -1.5 1.9
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.7 0.8 0.1 0.5
Loud music exposure frequency 1.1 1.2 2.1 -0.3 1.1 -1.5
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.7 0.7 0.2 0.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.1 0.6 -1.5 -1.2
Blood clot in the leg (DVT) 0.3 0.4 1.2 -0.3 -1.1 0.2
Medication: Paracetamol 0.8 1.3 3.7 -0.3 -0.3 -1.9
Headache pain in last month 0.1 0.2 0.3 0.5 0.6 -0.2
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 8.0 1.5 -2.8 0.0
Glaucoma (self-reported) 0.5 0.5 1.0 1.0 -0.8 -0.1
Gout (self-reported) 0.3 0.4 0.7 -0.8 0.6 -0.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.4 -1.6 -0.2 -1.0
Medication: Amlodipine 0.7 0.9 2.4 -0.0 1.5 0.7
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.1 1.1 -0.7 0.8
Birth weight 2.1 4.6 5.4 2.3 -2.0 2.1
Chronic bronchitis/emphysema (mother) 0.5 0.5 0.9 -0.9 0.8 -0.3
High blood pressure (siblings) 0.7 1.0 1.6 1.3 -1.0 0.7
Forced vital capacity (FVC), Best measure 0.0 0.1 0.3 -0.3 0.5 -0.2
Body fat percentage 0.0 0.1 0.1 -0.3 -0.1 -0.4
Leg fat percentage (right) 0.4 1.4 3.4 -0.9 -0.4 -1.8
Arm fat-free mass (right) 0.1 0.4 0.6 -0.3 -0.8 -0.8
Exposure to tobacco smoke outside home 1.0 1.4 2.1 0.0 1.5 -1.4
Comparative body size at age 10 1.1 3.0 4.2 -2.0 1.0 -2.0
Number of full brothers 0.6 0.8 1.7 0.4 1.3 -0.7
Worry too long after embarrassment 1.7 2.9 5.4 1.8 -2.3 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.9 4.0 -1.2 0.1 -2.0
Wheeze or whistling in the chest in last year 0.3 0.6 0.9 -0.7 0.7 -0.9
Number of children fathered 0.8 0.9 1.4 0.6 -1.2 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.0 -0.5 -0.4 1.0
Age at first live birth 0.8 1.4 2.6 0.1 1.2 1.6
Pulse wave peak to peak time 0.2 0.3 0.5 -0.3 0.4 -0.7
Health satisfaction 0.6 0.8 1.5 0.9 1.2 0.4
Shortness of breath walking on level ground 1.8 2.1 5.6 -0.9 2.4 -0.3
Qualifications: College or University degree 0.1 0.3 0.9 -0.4 0.2 0.9
Eye problems/disorders: None of the above 2.7 3.1 5.9 -2.4 1.9 0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 0.5 -0.4 0.7
Emphysema/chronic bronchitis 0.6 0.6 1.5 -0.3 1.2 -0.5
Medication for pain relief, constipation, heartburn 0.8 1.4 4.1 0.1 -0.4 2.0
Neck or shoulder pain in last month 1.4 1.9 4.7 2.2 -0.4 0.9
Medication: Blood pressure 1.5 2.7 6.5 -1.2 2.6 0.3
Angina (self-reported) 0.3 0.4 0.7 0.8 0.4 0.5
Migraine (self-reported) 0.2 0.3 0.8 0.3 0.9 -0.0
Medication: Ibuprofen 2.4 2.9 3.4 1.5 -1.7 -1.8
Medication: Allopurinol 1.2 1.6 2.1 -1.4 1.4 -0.7
Medication: Omeprazole 1.0 1.2 1.3 1.1 -1.1 -1.1
Medication: Seretide 50 evohaler 1.0 1.2 2.7 -1.6 0.6 -0.7
Mean time to correctly identify matches 0.1 0.2 0.4 0.6 0.3 0.2
Heart disease (mother) 1.4 1.7 3.6 -0.9 1.9 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.0 -0.6 0.8 1.4
Whole body fat mass 0.0 0.2 0.2 -0.4 -0.3 -0.5
Leg fat mass (right) 0.2 0.9 2.0 -0.7 -0.5 -1.4
Arm predicted mass (right) 0.1 0.4 0.8 -0.1 -0.9 -0.6
Pulse rate, automated reading 0.1 0.4 0.7 0.1 -0.8 -0.7
Alcohol intake frequency. 0.2 0.4 0.9 -1.0 0.5 0.1
Comparative height size at age 10 0.6 3.3 5.3 -2.3 0.2 2.1
Number of full sisters 0.5 0.6 1.6 0.1 -1.3 -0.2
Suffer from ‘nerves’ 0.1 0.2 0.4 0.4 -0.1 -0.7
Overall health rating 0.6 1.4 2.9 -0.6 0.9 -1.7
Chest pain or discomfort 1.1 1.5 2.3 -1.5 0.3 -1.5
Had major operations 0.1 0.1 0.1 0.3 -0.2 0.2
Age at last live birth 0.8 1.2 2.3 0.1 1.1 1.5
Family relationship satisfaction 1.7 2.2 4.3 -2.1 1.2 -0.8
Leg pain on walking 1.0 1.3 3.9 -0.0 2.0 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.4 0.8 -1.5 -0.6
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.2 -1.8 0.1 0.6
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.9 0.7 0.0 1.4
Medication: Aspirin 0.1 0.1 0.2 0.2 0.4 -0.4
Supplements: Vitamin C 0.3 0.3 1.0 0.0 1.0 -0.0
Knee pain experienced in last month 0.3 0.5 0.8 0.8 -0.9 0.0
Hypertension (Self-reported) 3.1 8.7 19.0 0.6 2.6 4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.1 3.6 7.0 1.7 -2.6 0.9
Illnesses of father: Heart disease 4.4 6.1 6.9 -2.2 2.6 -2.6
Illnesses of siblings: Diabetes 0.3 0.3 0.7 0.8 -0.4 -0.5
Smoking status: Previous 1.4 2.1 2.7 -1.6 1.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.7 -1.6 1.1 -0.6
Whole body fat-free mass 0.1 0.6 1.7 0.4 -1.3 -0.1
Leg fat-free mass (right) 0.1 0.7 1.7 0.5 -1.3 0.2
Arm fat percentage (left) 0.2 0.6 0.8 0.6 -0.9 -0.9
Average weekly red wine intake 1.6 2.4 3.2 1.2 -1.6 1.8
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.4 0.1 0.5 -1.6
Mood swings 0.2 0.3 0.5 0.3 -0.7 0.5
Loneliness, isolation 0.2 0.2 0.6 0.4 0.0 0.8
Long-standing illness, disability or infirmity 0.5 0.7 1.8 -1.3 0.6 -0.1
Ever had bowel cancer screening 1.6 1.9 2.2 1.5 -1.5 1.1
Diabetes diagnosed by doctor 0.1 0.2 0.5 0.3 -0.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 0.6 0.8 0.1
Friendships satisfaction 0.2 0.3 0.5 -0.5 0.7 0.3
Qualifications: nursing, teaching 0.8 1.3 2.1 -1.3 1.4 0.3
Commuting to job workplace: Walk 1.7 1.8 3.4 1.8 -0.1 1.4
Eye problems/disorders: Cataract 0.7 0.8 2.3 1.5 -0.0 0.4
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.0 1.0 -1.1 1.4
Medication for cholesterol 2.4 3.7 6.4 1.9 -2.5 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.4 -0.4 0.6 0.6
Back pain experienced in last month 0.4 0.5 0.7 -0.5 0.8 -0.8
Mineral and other dietary supplements 0.8 1.1 1.8 -1.4 1.1 -0.5
Breast cancer (self-reported) 2.0 2.4 3.9 -2.0 1.8 -0.3
Asthma (self-reported) 0.2 0.5 1.0 0.7 -0.2 1.0
Osteoporosis (self-reported) 0.9 1.1 1.5 1.2 -0.7 -1.1
Osteoarthritis (self-reported) 4.4 5.7 8.5 2.9 -2.9 0.5
Medication: Aspirin 0.1 0.1 0.2 -0.0 0.5 -0.0
Medication: Gliclazide 0.4 0.5 0.8 -0.6 -0.9 -0.4
Illnesses of father: None of the above (group 1) 1.1 1.3 1.8 1.4 -1.3 -0.7
Smoking status: Current 0.3 0.5 1.0 -0.0 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.6 1.0 -1.3 -0.2
Whole body water mass 0.1 0.7 1.8 0.4 -1.3 -0.1
Leg predicted mass (right) 0.1 0.5 1.4 0.4 -1.2 0.2
Arm fat mass (left) 0.3 1.1 1.9 0.3 -1.1 -1.4
Number of self-reported non-cancer illnesses 0.4 0.8 1.4 1.2 -0.4 0.9
Average weekly champagne plus white wine intake 0.7 0.9 2.7 -0.4 -0.1 1.6
Miserableness 1.3 2.2 3.6 1.2 -1.9 -1.3
Guilty feelings 0.1 0.1 0.1 -0.2 -0.4 -0.4
Wears glasses or contact lenses 0.3 0.4 0.7 0.1 -0.8 0.7
Ever taken oral contraceptive pill 0.6 0.7 1.1 -0.8 -1.0 -0.7
Hearing aid user 1.9 2.2 5.0 1.2 -2.2 0.4
Mother’s age at death 0.9 1.1 2.8 0.7 0.1 1.7
Financial situation satisfaction 0.3 0.4 0.5 -0.7 0.5 -0.6
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.3 1.4 -0.2 1.5
Commuting to job workplace: Public transport 0.7 0.8 2.1 -0.3 1.5 -0.5
Eye problems/disorders: Glaucoma 1.1 1.3 2.7 1.6 -1.1 0.2
Medication: Blood pressure 2.3 4.3 7.7 -0.3 2.3 2.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.3 -1.1 0.1 -0.0
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.0 1.4 -0.7 0.7
High cholesterol (Self-reported) 0.2 0.4 1.1 0.1 -0.5 1.1
Medication: Bendroflumethiazide 1.1 1.7 2.6 -0.8 1.6 1.4
Medication: Paracetamol 0.7 1.2 3.3 0.2 -0.3 -1.8
Medication: Lisinopril 1.4 1.8 2.9 -1.5 1.7 0.6
Medication: Atorvastatin 0.8 1.0 2.9 0.0 0.2 1.7
Illnesses of father: High blood pressure 2.6 3.2 5.6 -1.5 2.4 1.3
Alcohol drinker status: Never 0.3 0.3 0.8 -0.4 0.9 0.2
Ever smoked 1.1 1.9 2.7 -1.6 0.9 -1.5
Basal metabolic rate 0.1 0.6 1.7 0.3 -1.3 -0.1
Leg fat percentage (left) 0.4 1.3 3.0 -0.9 -0.3 -1.7
Arm fat-free mass (left) 0.2 0.9 2.0 -0.2 -1.4 -0.8
Number of operations (self-reported) 0.8 1.2 1.8 1.1 -1.4 0.8
Average weekly beer plus cider intake 0.5 0.7 1.5 1.2 -0.5 -0.7
Irritability 1.8 3.1 4.4 2.1 -1.1 1.9
Risk taking 2.4 3.5 4.2 -1.8 2.0 -1.8
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.4 0.3 -1.6 -0.0
Fractured/broken bones in last 5 years 0.8 1.0 1.6 1.1 -0.5 1.3
Age started oral contraceptive pill 2.3 2.9 7.0 1.2 -0.5 2.6
Diastolic blood pressure, automated reading 1.6 4.9 11.0 1.9 -0.3 3.3
Ever depressed for a whole week 0.1 0.1 0.1 0.2 0.2 0.4
Unable to work because of sickness or disability 0.8 1.1 1.6 -1.1 0.6 -1.3
Commuting to job workplace: Cycle 0.8 1.0 1.8 0.8 -1.3 0.8
Myopia 0.2 0.2 0.4 -0.4 0.6 0.4
Vascular/heart problems diagnosed by doctor 2.4 6.6 13.9 -0.8 -2.3 -3.7
Cholesterol lowering medication 0.3 0.4 0.9 -0.2 -0.9 0.5
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.0 0.4 -0.5 -1.4
Pain experienced in last month 0.4 0.7 1.5 -1.2 0.6 -0.6
Supplements: Calcium 0.3 0.3 0.5 0.4 -0.6 -0.7
Basal cell carcinoma (self-reported) 0.7 0.8 1.3 -0.3 -1.1 -1.0
Heart attack/myocardial infarction (self-reported) 1.6 2.0 4.2 0.6 2.0 1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 -0.6 -0.7 0.1
Heart disease (siblings) 0.4 0.5 1.1 0.5 1.0 -0.5
Alcohol drinker status: Previous 0.3 0.4 0.6 0.6 -0.7 -0.5
Pack years of smoking 0.8 1.2 2.1 -1.2 1.4 -0.0
Impedance of whole body 1.2 6.2 10.2 -1.3 2.6 3.2
Leg fat mass (left) 0.3 1.0 2.3 -0.8 -0.4 -1.5
Arm predicted mass (left) 0.1 0.8 1.3 -0.2 -1.2 -0.9