Hub : Genes

NDUFAF7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.406	0.1030	3.9e-04	0.049	NA	0.053	NA	0.118	1.4e-02	NA	1.1e-02	NA	2.4e-04
2	GTEx	Testis	0.447	0.0650	1.9e-13	0.404	NA	0.461	NA	0.463	3.1e-19	NA	1.2e-22	NA	8.9e-23
3	ROSMAP	Brain Pre-frontal Cortex	0.128	0.0343	5.9e-07	0.071	0.075	0.097	0.09	0.078	1.7e-09	6.3e-10	1.7e-12	1.1e-11	2.9e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.1	3.3	4.8	-2.2	1.9	-1.3
Bipolar Disorder or Schizophrenia	4.3	10.5	17.1	-4.1	3.6	-1.3
Depressed Affect (Nagel 2018)	0.3	0.6	1.7	-0.1	-0.3	-1.3
Depression (Nagel 2018)	0.7	1.0	2.1	0.3	-0.8	-1.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.0	0.0	-0.2	-1.4
Neuroticism (Nagel 2018)	0.5	1.1	2.0	1.4	-1.1	0.4
Schizophrenia (2018)	3.5	7.3	12.7	-3.6	3.0	-0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.5	-0.2	0.0
Worry (Nagel 2018)	0.2	0.5	1.2	1.1	-0.0	0.5
Alzheimer’s Disease (in mother)	1.6	1.8	5.0	0.6	-2.2	0.5
Alzheimer’s Disease (in father)	0.8	0.9	1.5	0.2	-1.2	-1.1
Alzheimer’s Disease (including proxy)	2.1	3.0	6.4	-0.0	-2.5	-1.6
Crohns Disease (2017)	0.3	0.7	1.3	-0.5	1.1	0.7
Irritable Bowel Disease (IBD)	2.2	5.2	8.5	-2.6	2.9	-0.7
Ulcerative Colitis (UC)	4.0	7.6	12.0	-3.1	3.5	-0.9
Major Depression (MDD)	1.3	1.6	3.9	0.1	0.9	2.0
Reaction Time	0.4	0.7	1.0	-0.5	1.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.9	2.1	2.6	1.4	-1.6	-1.3
Breast Cancer	0.3	0.7	1.1	1.0	0.1	1.1
Ovarian Cancer	2.3	3.0	5.1	1.9	-2.3	0.6
Prostate Cancer	0.7	0.9	1.4	1.2	-0.8	-0.8
Age at First Birth	0.8	1.1	2.9	-0.7	1.7	-0.1
Bipolar Disorder (2011)	3.1	3.0	6.2	-2.5	1.6	-0.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	0.2	-0.6	-1.3
Coronary Artery Disease (CAD)	0.4	0.5	1.1	-1.1	0.4	-0.6
Crohns Disease (2012)	0.3	0.5	0.6	0.6	0.7	0.7
Mean Putamen Volume	0.6	0.7	1.9	0.2	-0.1	-1.4
Fasting Glucose	2.8	3.3	8.7	0.7	-0.8	3.0
HbA1C	0.3	0.4	0.7	0.5	-0.3	-0.9
HDL Cholesterol	0.9	1.5	3.9	-0.5	2.0	0.6
LDL Cholesterol	0.2	0.4	0.9	-0.1	-0.3	-1.0
Lupus	0.2	0.3	0.6	0.8	-0.0	-0.5
Neuroticism (2016)	1.3	1.9	4.2	2.0	-1.1	0.4
Primary Biliary Cirrhosis	0.4	0.6	1.4	1.2	0.3	0.5
Rheumatoid Arthritis	0.9	1.3	1.8	1.1	-1.4	0.9
Schizophrenia (2014)	4.2	9.3	15.8	-4.0	3.5	-0.3
Triglycerides	0.1	0.2	0.6	-0.1	-0.8	-0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.6	-0.2	-0.3	-1.9
Ulcerative Colitis	5.3	7.7	12.0	-3.5	3.1	-1.1
Blood Eosinophil Count	0.5	3.7	8.4	-0.7	1.5	2.9
Blood Platelet Count	0.3	3.2	6.1	-1.9	2.5	-0.3
Blood Red Count	0.6	5.9	11.6	-3.4	2.0	-1.5
Blood White Count	1.1	7.9	13.2	-3.6	2.8	-1.7
Heel T-Score	1.5	11.8	14.8	-3.2	3.9	-3.3
BMI	0.3	1.9	4.5	-0.2	-1.1	-2.1
Height	0.7	13.7	36.8	-0.9	1.9	6.1
Waist Hip Ratio (WHR)	0.6	2.9	4.2	-2.0	0.8	-2.0
Systolic Blood Pressure	1.8	9.0	21.6	1.0	2.1	4.7
Smoking Status	0.5	1.3	2.7	-0.9	-0.5	-1.7
Allergy or Eczema	0.2	0.7	1.7	1.3	-0.5	0.3
Cardiovascular Disease	1.2	4.0	10.4	0.7	1.1	3.2
Hypothyroidism (self reported)	0.3	0.6	1.4	-0.7	0.1	-1.2
Respiratory disease	0.0	0.1	0.2	0.4	0.0	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.1	-0.1	-0.8
Lung FEV1/FVC ratio	0.8	4.0	5.5	1.3	-2.4	-2.2
Lung FVC	0.2	1.2	2.5	-1.6	0.6	-0.8
Neuroticism	0.7	1.7	3.0	1.7	-1.1	0.9
Chronotype (morning person)	0.7	1.7	2.1	1.1	-1.4	1.4
Hair Pigment	0.2	4.3	8.1	2.8	-1.7	1.4
Tanning	0.2	2.9	6.2	-1.3	2.5	-0.7
Hand grip strength (left)	0.3	0.7	1.3	-1.1	-0.4	0.9
Number of treatments/medications taken	0.1	0.2	0.6	-0.0	0.8	-0.1
Average weekly spirits intake	1.9	2.3	5.9	-2.4	0.6	-0.8
Sensitivity / hurt feelings	0.5	0.8	1.0	1.0	-0.8	0.9
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.4	0.8	-1.4	-1.5
Hearing difficulty/problems: Yes	2.2	3.4	6.7	1.7	-2.6	0.7
Relative age of first facial hair	0.1	0.2	0.6	-0.2	0.7	0.3
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	5.2	-2.3	2.0	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.2	-0.6	0.0	-1.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	0.1	-1.3	0.6
Systolic blood pressure, automated reading	1.9	5.4	11.2	2.2	0.1	3.3
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.4	0.8	-2.1	-0.4
Angina	0.4	0.5	0.6	0.8	0.6	0.8
Medication for hormone replacement therapy	4.5	5.0	7.5	-2.4	2.7	-1.2
Vitamin and mineral supplements	0.1	0.2	0.4	-0.3	-0.6	0.3
Supplements: Zinc	0.8	0.9	1.6	1.0	1.3	-0.1
Medication: Co-codamol	0.2	0.2	0.5	0.4	-0.1	0.7
Medication: Metformin	0.1	0.1	0.3	0.5	-0.3	0.1
Diabetes (father)	0.8	1.0	1.7	1.0	-1.3	-0.4
Diabetes (mother)	0.5	0.6	1.6	1.3	-0.1	0.5
Severe depression (siblings)	2.0	2.2	5.5	0.1	1.1	-2.3
Pack years adult smoking proportion	0.5	0.8	1.4	-1.0	1.2	-0.4
Impedance of leg (right)	1.0	4.9	7.7	-2.2	2.8	1.4
Leg fat-free mass (left)	0.1	0.4	1.1	0.3	-1.1	0.1
Trunk fat percentage	0.0	0.1	0.2	-0.4	0.3	0.2
Hand grip strength (right)	0.6	1.5	2.1	-0.9	-1.3	1.4
Townsend deprivation index at recruitment	0.3	0.5	1.2	1.1	-0.5	-0.0
Current tobacco smoking	0.4	0.7	1.3	0.2	-0.9	-1.2
Average weekly fortified wine intake	1.0	1.2	2.4	0.6	-0.9	1.6
Maternal smoking around birth	0.2	0.3	0.7	0.8	-0.3	-0.5
Fed-up feelings	1.0	1.9	4.0	-2.0	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.1	1.1	-2.0	-1.7
Relative age voice broke	0.3	0.4	1.1	0.3	1.1	-0.2
Taking other prescription medications	0.2	0.3	1.0	0.0	0.2	-1.0
Age when periods started (menarche)	0.0	0.1	0.3	0.2	0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.4	-0.6	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.7	0.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-1.0	0.5	-0.1
Qualifications: CSEs or equivalent	1.0	1.3	1.9	-0.8	1.4	-1.2
Serious illness, injury or assault to yourself	1.6	2.0	4.2	-2.1	0.7	-1.1
High blood pressure	3.0	8.3	18.3	0.5	2.5	4.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	1.3	-0.2	-0.8
Multivitamins +/- minerals	0.6	0.8	1.5	0.9	-0.3	-1.2
Stomach or abdominal pain in last month	0.8	1.0	1.6	1.2	-1.3	-0.2
Supplements: Glucosamine	0.3	0.4	0.5	-0.2	-0.7	-0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.0	0.6	0.2
Medication: Atenolol	2.1	2.7	7.8	-0.2	2.8	0.4
Medication: Levothyroxine sodium	0.6	1.0	2.7	-1.6	-0.2	-0.5
Sitting height	0.2	1.5	4.2	0.2	-0.6	2.0
Chronic bronchitis/emphysema (father)	1.8	2.1	2.8	1.7	-1.0	1.5
High blood pressure (mother)	0.8	1.1	1.6	0.0	1.3	1.3
Body mass index (BMI)	0.6	2.7	5.6	0.5	-1.6	-2.4
Impedance of leg (left)	1.2	5.6	7.8	-2.3	2.8	1.9
Leg predicted mass (left)	0.1	0.4	1.1	0.4	-1.0	0.1
Trunk fat mass	0.0	0.0	0.1	-0.3	-0.1	-0.0
Waist circumference	0.5	2.0	5.3	0.1	-0.9	-2.3
Number of incorrect matches in round	1.3	2.2	5.2	-1.2	2.3	0.4
Past tobacco smoking	1.6	2.9	3.3	1.8	-1.7	1.6
Alcohol usually taken with meals	0.3	0.5	0.6	0.8	-0.5	0.7
Nervous feelings	1.5	2.8	6.6	2.6	-1.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	2.8	1.7	-1.5	0.0
Hearing difficulty/problems with background noise	3.0	4.9	7.2	2.7	-2.7	0.5
Hair/balding pattern: Pattern 2	0.6	0.7	2.0	0.2	0.3	-1.4
Had menopause	0.1	0.1	0.2	0.4	-0.5	-0.2
Had other major operations	0.4	0.5	0.6	-0.7	0.8	-0.5
Forced vital capacity (FVC)	0.1	0.3	0.8	-0.9	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.3	-0.8	1.0	-1.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.0	0.2	-0.8	1.7
Qualifications: None of the above	0.5	1.0	1.8	-1.4	0.8	-0.8
Financial difficulties in last 2 years	0.8	1.1	2.9	0.3	-0.7	-1.7
Mouth/teeth dental problems	1.3	2.0	4.5	-2.1	1.3	0.2
Heart attack	1.5	1.9	4.3	0.7	2.1	1.0
Allergy	0.2	0.4	1.1	-1.1	0.0	-0.2
Pain all over the body in last month	0.5	0.5	1.1	-0.6	1.1	0.2
Diabetes (self-reported)	0.2	0.2	0.7	0.1	-0.1	-0.8
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	8.8	3.0	-1.6	1.3
Medication: Ramipril	0.1	0.1	0.4	0.0	0.7	-0.0
Medication: Simvastatin	0.1	0.1	0.2	-0.4	-0.3	-0.2
Fluid intelligence score	0.3	0.6	1.3	0.1	-1.1	-0.8
Illnesses of siblings	0.2	0.3	0.8	-0.9	0.1	0.1
Neuroticism score	0.7	1.5	2.3	1.5	-1.0	1.1
Weight	0.1	0.5	1.5	0.3	-1.2	-0.3
Impedance of arm (right)	1.3	6.0	14.4	-0.3	1.9	3.8
Arm fat percentage (right)	0.2	0.8	1.3	0.6	-1.2	-0.9
Trunk fat-free mass	0.1	0.8	2.1	0.5	-1.4	0.1
Hip circumference	0.2	0.7	1.2	0.8	-1.1	-0.6
Time employed in main current job	0.4	0.5	1.3	-0.1	1.1	0.1
Alcohol intake versus 10 years previously	0.4	0.6	1.0	-1.0	0.8	0.2
Father’s age at death	1.1	1.4	2.1	0.8	-1.4	1.3
Worrier / anxious feelings	0.0	0.1	0.1	0.4	-0.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.0	-0.0	-1.4	-0.3
Falls in the last year	1.3	1.8	2.8	1.7	-1.1	1.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.8	-1.2	0.4
Number of live births	1.8	2.6	5.6	2.4	-0.2	1.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.4	-0.6	-0.7	-0.5
Pulse rate	0.1	0.2	0.3	-0.3	0.3	-0.5
Happiness	0.2	0.3	0.5	0.3	0.4	-0.7
Noisy workplace	0.3	0.4	0.9	1.0	-0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.4	0.6	0.7	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	0.0	-0.7	1.1
Mouth/teeth dental problems: Dentures	1.5	2.5	6.1	2.5	-1.0	0.6
Asthma	0.4	0.7	1.1	1.1	-0.5	0.9
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	3.1	1.8	-1.7	-1.4
Medication: Cholesterol lowering	2.3	3.5	5.3	-2.3	2.0	-1.1
Depression (self-reported)	0.5	0.6	0.7	0.8	-0.8	-0.8
Medication: Lansoprazole	1.4	1.6	3.1	-1.3	0.4	-1.8
Prospective memory result	4.6	5.7	11.4	-2.2	3.4	-0.9
Lung cancer (father)	1.2	1.4	1.8	1.0	-1.2	-1.4
Illnesses of mother	2.0	2.5	3.6	1.6	-1.9	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	0.2	-0.3	-0.7
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	0.4	-0.5	0.9
Impedance of arm (left)	1.5	6.8	16.7	0.1	1.9	4.1
Arm fat mass (right)	0.3	1.0	1.8	0.3	-1.4	-1.1
Trunk predicted mass	0.1	0.8	2.1	0.5	-1.5	-0.0
Standing height	0.6	6.1	17.6	-0.5	0.6	4.2
Length of working week for main job	3.7	4.1	8.7	-3.0	0.8	-1.7
Exposure to tobacco smoke at home	0.8	0.9	0.9	-0.9	0.9	1.0
Breastfed as a baby	0.4	0.5	1.1	-0.6	0.2	1.1
Tense / ‘highly strung’	0.2	0.3	0.6	0.8	0.5	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.9	-0.1	-0.9	-2.0
Hair/balding pattern: Pattern 4	0.5	1.2	1.6	1.2	-1.3	0.7
Birth weight of first child	0.6	1.0	3.0	-1.7	0.1	0.1
Peak expiratory flow (PEF)	0.1	0.2	0.3	0.5	-0.3	-0.4
Pulse wave reflection index	1.7	2.1	3.8	0.4	-1.5	1.9
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.8	0.1	0.5
Loud music exposure frequency	1.1	1.2	2.1	-0.3	1.1	-1.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.7	0.7	0.2	0.8
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	0.6	-1.5	-1.2
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.3	-1.1	0.2
Medication: Paracetamol	0.8	1.3	3.7	-0.3	-0.3	-1.9
Headache pain in last month	0.1	0.2	0.3	0.5	0.6	-0.2
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	8.0	1.5	-2.8	0.0
Glaucoma (self-reported)	0.5	0.5	1.0	1.0	-0.8	-0.1
Gout (self-reported)	0.3	0.4	0.7	-0.8	0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.4	-1.6	-0.2	-1.0
Medication: Amlodipine	0.7	0.9	2.4	-0.0	1.5	0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.1	1.1	-0.7	0.8
Birth weight	2.1	4.6	5.4	2.3	-2.0	2.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.9	-0.9	0.8	-0.3
High blood pressure (siblings)	0.7	1.0	1.6	1.3	-1.0	0.7
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	-0.3	0.5	-0.2
Body fat percentage	0.0	0.1	0.1	-0.3	-0.1	-0.4
Leg fat percentage (right)	0.4	1.4	3.4	-0.9	-0.4	-1.8
Arm fat-free mass (right)	0.1	0.4	0.6	-0.3	-0.8	-0.8
Exposure to tobacco smoke outside home	1.0	1.4	2.1	0.0	1.5	-1.4
Comparative body size at age 10	1.1	3.0	4.2	-2.0	1.0	-2.0
Number of full brothers	0.6	0.8	1.7	0.4	1.3	-0.7
Worry too long after embarrassment	1.7	2.9	5.4	1.8	-2.3	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	4.0	-1.2	0.1	-2.0
Wheeze or whistling in the chest in last year	0.3	0.6	0.9	-0.7	0.7	-0.9
Number of children fathered	0.8	0.9	1.4	0.6	-1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.5	-0.4	1.0
Age at first live birth	0.8	1.4	2.6	0.1	1.2	1.6
Pulse wave peak to peak time	0.2	0.3	0.5	-0.3	0.4	-0.7
Health satisfaction	0.6	0.8	1.5	0.9	1.2	0.4
Shortness of breath walking on level ground	1.8	2.1	5.6	-0.9	2.4	-0.3
Qualifications: College or University degree	0.1	0.3	0.9	-0.4	0.2	0.9
Eye problems/disorders: None of the above	2.7	3.1	5.9	-2.4	1.9	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.5	-0.4	0.7
Emphysema/chronic bronchitis	0.6	0.6	1.5	-0.3	1.2	-0.5
Medication for pain relief, constipation, heartburn	0.8	1.4	4.1	0.1	-0.4	2.0
Neck or shoulder pain in last month	1.4	1.9	4.7	2.2	-0.4	0.9
Medication: Blood pressure	1.5	2.7	6.5	-1.2	2.6	0.3
Angina (self-reported)	0.3	0.4	0.7	0.8	0.4	0.5
Migraine (self-reported)	0.2	0.3	0.8	0.3	0.9	-0.0
Medication: Ibuprofen	2.4	2.9	3.4	1.5	-1.7	-1.8
Medication: Allopurinol	1.2	1.6	2.1	-1.4	1.4	-0.7
Medication: Omeprazole	1.0	1.2	1.3	1.1	-1.1	-1.1
Medication: Seretide 50 evohaler	1.0	1.2	2.7	-1.6	0.6	-0.7
Mean time to correctly identify matches	0.1	0.2	0.4	0.6	0.3	0.2
Heart disease (mother)	1.4	1.7	3.6	-0.9	1.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	-0.6	0.8	1.4
Whole body fat mass	0.0	0.2	0.2	-0.4	-0.3	-0.5
Leg fat mass (right)	0.2	0.9	2.0	-0.7	-0.5	-1.4
Arm predicted mass (right)	0.1	0.4	0.8	-0.1	-0.9	-0.6
Pulse rate, automated reading	0.1	0.4	0.7	0.1	-0.8	-0.7
Alcohol intake frequency.	0.2	0.4	0.9	-1.0	0.5	0.1
Comparative height size at age 10	0.6	3.3	5.3	-2.3	0.2	2.1
Number of full sisters	0.5	0.6	1.6	0.1	-1.3	-0.2
Suffer from ‘nerves’	0.1	0.2	0.4	0.4	-0.1	-0.7
Overall health rating	0.6	1.4	2.9	-0.6	0.9	-1.7
Chest pain or discomfort	1.1	1.5	2.3	-1.5	0.3	-1.5
Had major operations	0.1	0.1	0.1	0.3	-0.2	0.2
Age at last live birth	0.8	1.2	2.3	0.1	1.1	1.5
Family relationship satisfaction	1.7	2.2	4.3	-2.1	1.2	-0.8
Leg pain on walking	1.0	1.3	3.9	-0.0	2.0	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.4	0.8	-1.5	-0.6
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.2	-1.8	0.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.9	0.7	0.0	1.4
Medication: Aspirin	0.1	0.1	0.2	0.2	0.4	-0.4
Supplements: Vitamin C	0.3	0.3	1.0	0.0	1.0	-0.0
Knee pain experienced in last month	0.3	0.5	0.8	0.8	-0.9	0.0
Hypertension (Self-reported)	3.1	8.7	19.0	0.6	2.6	4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	7.0	1.7	-2.6	0.9
Illnesses of father: Heart disease	4.4	6.1	6.9	-2.2	2.6	-2.6
Illnesses of siblings: Diabetes	0.3	0.3	0.7	0.8	-0.4	-0.5
Smoking status: Previous	1.4	2.1	2.7	-1.6	1.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.7	-1.6	1.1	-0.6
Whole body fat-free mass	0.1	0.6	1.7	0.4	-1.3	-0.1
Leg fat-free mass (right)	0.1	0.7	1.7	0.5	-1.3	0.2
Arm fat percentage (left)	0.2	0.6	0.8	0.6	-0.9	-0.9
Average weekly red wine intake	1.6	2.4	3.2	1.2	-1.6	1.8
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.4	0.1	0.5	-1.6
Mood swings	0.2	0.3	0.5	0.3	-0.7	0.5
Loneliness, isolation	0.2	0.2	0.6	0.4	0.0	0.8
Long-standing illness, disability or infirmity	0.5	0.7	1.8	-1.3	0.6	-0.1
Ever had bowel cancer screening	1.6	1.9	2.2	1.5	-1.5	1.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.3	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.6	0.8	0.1
Friendships satisfaction	0.2	0.3	0.5	-0.5	0.7	0.3
Qualifications: nursing, teaching	0.8	1.3	2.1	-1.3	1.4	0.3
Commuting to job workplace: Walk	1.7	1.8	3.4	1.8	-0.1	1.4
Eye problems/disorders: Cataract	0.7	0.8	2.3	1.5	-0.0	0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.0	1.0	-1.1	1.4
Medication for cholesterol	2.4	3.7	6.4	1.9	-2.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	-0.4	0.6	0.6
Back pain experienced in last month	0.4	0.5	0.7	-0.5	0.8	-0.8
Mineral and other dietary supplements	0.8	1.1	1.8	-1.4	1.1	-0.5
Breast cancer (self-reported)	2.0	2.4	3.9	-2.0	1.8	-0.3
Asthma (self-reported)	0.2	0.5	1.0	0.7	-0.2	1.0
Osteoporosis (self-reported)	0.9	1.1	1.5	1.2	-0.7	-1.1
Osteoarthritis (self-reported)	4.4	5.7	8.5	2.9	-2.9	0.5
Medication: Aspirin	0.1	0.1	0.2	-0.0	0.5	-0.0
Medication: Gliclazide	0.4	0.5	0.8	-0.6	-0.9	-0.4
Illnesses of father: None of the above (group 1)	1.1	1.3	1.8	1.4	-1.3	-0.7
Smoking status: Current	0.3	0.5	1.0	-0.0	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.6	1.0	-1.3	-0.2
Whole body water mass	0.1	0.7	1.8	0.4	-1.3	-0.1
Leg predicted mass (right)	0.1	0.5	1.4	0.4	-1.2	0.2
Arm fat mass (left)	0.3	1.1	1.9	0.3	-1.1	-1.4
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	1.2	-0.4	0.9
Average weekly champagne plus white wine intake	0.7	0.9	2.7	-0.4	-0.1	1.6
Miserableness	1.3	2.2	3.6	1.2	-1.9	-1.3
Guilty feelings	0.1	0.1	0.1	-0.2	-0.4	-0.4
Wears glasses or contact lenses	0.3	0.4	0.7	0.1	-0.8	0.7
Ever taken oral contraceptive pill	0.6	0.7	1.1	-0.8	-1.0	-0.7
Hearing aid user	1.9	2.2	5.0	1.2	-2.2	0.4
Mother’s age at death	0.9	1.1	2.8	0.7	0.1	1.7
Financial situation satisfaction	0.3	0.4	0.5	-0.7	0.5	-0.6
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.3	1.4	-0.2	1.5
Commuting to job workplace: Public transport	0.7	0.8	2.1	-0.3	1.5	-0.5
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	1.6	-1.1	0.2
Medication: Blood pressure	2.3	4.3	7.7	-0.3	2.3	2.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-1.1	0.1	-0.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.0	1.4	-0.7	0.7
High cholesterol (Self-reported)	0.2	0.4	1.1	0.1	-0.5	1.1
Medication: Bendroflumethiazide	1.1	1.7	2.6	-0.8	1.6	1.4
Medication: Paracetamol	0.7	1.2	3.3	0.2	-0.3	-1.8
Medication: Lisinopril	1.4	1.8	2.9	-1.5	1.7	0.6
Medication: Atorvastatin	0.8	1.0	2.9	0.0	0.2	1.7
Illnesses of father: High blood pressure	2.6	3.2	5.6	-1.5	2.4	1.3
Alcohol drinker status: Never	0.3	0.3	0.8	-0.4	0.9	0.2
Ever smoked	1.1	1.9	2.7	-1.6	0.9	-1.5
Basal metabolic rate	0.1	0.6	1.7	0.3	-1.3	-0.1
Leg fat percentage (left)	0.4	1.3	3.0	-0.9	-0.3	-1.7
Arm fat-free mass (left)	0.2	0.9	2.0	-0.2	-1.4	-0.8
Number of operations (self-reported)	0.8	1.2	1.8	1.1	-1.4	0.8
Average weekly beer plus cider intake	0.5	0.7	1.5	1.2	-0.5	-0.7
Irritability	1.8	3.1	4.4	2.1	-1.1	1.9
Risk taking	2.4	3.5	4.2	-1.8	2.0	-1.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.4	0.3	-1.6	-0.0
Fractured/broken bones in last 5 years	0.8	1.0	1.6	1.1	-0.5	1.3
Age started oral contraceptive pill	2.3	2.9	7.0	1.2	-0.5	2.6
Diastolic blood pressure, automated reading	1.6	4.9	11.0	1.9	-0.3	3.3
Ever depressed for a whole week	0.1	0.1	0.1	0.2	0.2	0.4
Unable to work because of sickness or disability	0.8	1.1	1.6	-1.1	0.6	-1.3
Commuting to job workplace: Cycle	0.8	1.0	1.8	0.8	-1.3	0.8
Myopia	0.2	0.2	0.4	-0.4	0.6	0.4
Vascular/heart problems diagnosed by doctor	2.4	6.6	13.9	-0.8	-2.3	-3.7
Cholesterol lowering medication	0.3	0.4	0.9	-0.2	-0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.0	0.4	-0.5	-1.4
Pain experienced in last month	0.4	0.7	1.5	-1.2	0.6	-0.6
Supplements: Calcium	0.3	0.3	0.5	0.4	-0.6	-0.7
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-0.3	-1.1	-1.0
Heart attack/myocardial infarction (self-reported)	1.6	2.0	4.2	0.6	2.0	1.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.6	-0.7	0.1
Heart disease (siblings)	0.4	0.5	1.1	0.5	1.0	-0.5
Alcohol drinker status: Previous	0.3	0.4	0.6	0.6	-0.7	-0.5
Pack years of smoking	0.8	1.2	2.1	-1.2	1.4	-0.0
Impedance of whole body	1.2	6.2	10.2	-1.3	2.6	3.2
Leg fat mass (left)	0.3	1.0	2.3	-0.8	-0.4	-1.5
Arm predicted mass (left)	0.1	0.8	1.3	-0.2	-1.2	-0.9