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chr3:48,012,797-51,320,800

Best TWAS P=1.11e-14 · Best GWAS P=9.21e-12 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HEMK1	0.04	0.05	lasso	3	0.05	2.6e-06	-5.0	5.1	2.7e-07	-0.23	0.98	0.01	FALSE
2	GTEx	Adipose Subcutaneous	HYAL1	0.09	0.06	lasso	1	0.05	4.3e-05	-5.3	-5.3	1.0e-07	0.15	0.60	0.06	TRUE
3	GTEx	Adipose Visceral Omentum	CYB561D2	0.20	0.08	lasso	8	0.11	4.0e-06	-5.4	6.2	7.4e-10	-0.37	0.17	0.72	TRUE
4	GTEx	Artery Tibial	HEMK1	0.03	0.03	enet	3	0.02	7.1e-03	-5.3	5.2	1.6e-07	-0.21	0.64	0.09	FALSE
5	GTEx	Brain Caudate basal ganglia	HEMK1	0.15	0.12	lasso	9	0.13	1.2e-04	-5.2	5.4	5.9e-08	-0.23	0.56	0.27	FALSE
6	GTEx	Brain Cortex	HEMK1	0.16	0.01	enet	19	0.03	6.1e-02	-5.4	5.4	6.7e-08	0.00	0.12	0.08	FALSE
7	GTEx	Brain Putamen basal ganglia	SEMA3B-AS1	0.18	0.05	lasso	7	0.03	6.0e-02	-5.2	-5.4	8.0e-08	0.27	0.10	0.23	FALSE
8	GTEx	Cells Transformed fibroblasts	HEMK1	0.07	0.06	lasso	6	0.09	5.5e-07	-5.0	7.1	1.4e-12	-0.28	0.78	0.21	FALSE
9	GTEx	Cells Transformed fibroblasts	TCTA	0.07	0.05	enet	14	0.07	9.4e-06	-3.6	5.8	6.5e-09	-0.63	0.07	0.82	TRUE
10	GTEx	Cells Transformed fibroblasts	SEMA3B-AS1	0.15	0.01	enet	3	0.00	3.9e-01	-5.6	-5.5	4.0e-08	0.18	0.31	0.10	TRUE
11	GTEx	Colon Transverse	C3orf18	0.04	0.01	lasso	4	0.00	1.8e-01	-4.9	-5.2	2.0e-07	0.23	0.29	0.10	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	HYAL1	0.30	0.13	lasso	9	0.10	2.1e-04	-5.3	-5.5	4.8e-08	0.16	0.39	0.06	FALSE
13	GTEx	Esophagus Mucosa	CYB561D2	0.07	0.02	lasso	4	0.02	3.1e-02	-5.1	5.6	2.7e-08	-0.23	0.22	0.29	FALSE
14	GTEx	Esophagus Muscularis	RASSF1	0.10	0.00	lasso	7	0.01	8.7e-02	-5.6	-6.8	8.1e-12	0.33	0.15	0.12	TRUE
15	GTEx	Esophagus Muscularis	HYAL1	0.11	0.08	lasso	5	0.05	3.3e-04	-5.3	-5.3	9.6e-08	0.16	0.92	0.03	FALSE
16	GTEx	Esophagus Muscularis	SEMA3B-AS1	0.47	0.00	lasso	7	0.00	5.9e-01	-4.6	-6.0	2.5e-09	0.28	0.19	0.12	FALSE
17	GTEx	Heart Atrial Appendage	HYAL1	0.23	0.10	enet	14	0.13	1.5e-06	-5.2	-6.7	1.8e-11	0.24	0.59	0.10	TRUE
18	GTEx	Heart Left Ventricle	C3orf18	0.06	0.05	lasso	4	0.04	2.6e-03	-5.0	-5.2	2.1e-07	0.21	0.70	0.07	FALSE
19	GTEx	Heart Left Ventricle	DAG1	0.06	0.02	enet	14	0.02	3.2e-02	-3.5	5.2	1.8e-07	-0.63	0.21	0.46	FALSE
20	GTEx	Lung	HEMK1	0.03	0.01	enet	17	0.00	3.0e-01	-4.6	6.7	2.3e-11	-0.22	0.20	0.12	FALSE
21	GTEx	Muscle Skeletal	SEMA3B-AS1	0.17	0.01	lasso	7	0.02	8.3e-03	-5.1	-5.6	1.8e-08	0.11	0.50	0.04	FALSE
22	GTEx	Nerve Tibial	RASSF1	0.05	0.03	enet	19	0.02	1.0e-02	-5.6	-6.5	5.8e-11	0.29	0.51	0.07	TRUE
23	GTEx	Nerve Tibial	HYAL1	0.08	0.06	enet	14	0.05	3.6e-04	-6.3	-6.5	7.8e-11	0.77	0.07	0.82	TRUE
24	GTEx	Nerve Tibial	U73166.2	0.07	0.03	lasso	3	0.03	2.8e-03	-5.3	5.5	3.4e-08	-0.15	0.47	0.09	TRUE
25	GTEx	Nerve Tibial	SEMA3B-AS1	0.25	0.04	lasso	5	0.03	3.3e-03	-5.2	-6.2	5.5e-10	0.26	0.86	0.07	FALSE
26	GTEx	Prostate	C3orf18	0.18	0.08	lasso	9	0.11	1.1e-03	-6.2	-5.9	4.7e-09	0.37	0.16	0.28	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	CYB561D2	0.08	0.01	enet	7	0.02	2.3e-02	-5.4	6.5	6.0e-11	-0.33	0.18	0.27	FALSE
28	GTEx	Skin Sun Exposed Lower leg	CYB561D2	0.13	0.02	lasso	3	0.05	5.7e-05	-4.6	6.3	3.6e-10	-0.32	0.70	0.11	FALSE
29	GTEx	Spleen	XXcos-LUCA11.4	0.10	0.08	lasso	5	0.02	9.0e-02	-5.0	-5.2	1.5e-07	0.21	0.19	0.05	FALSE
30	GTEx	Testis	CACNA2D2	0.08	0.06	lasso	6	0.05	4.1e-03	-5.3	6.3	2.6e-10	-0.23	0.56	0.12	FALSE
31	GTEx	Thyroid	CYB561D2	0.08	0.02	enet	9	0.03	2.3e-03	-5.4	5.9	3.4e-09	-0.40	0.20	0.62	FALSE
32	GTEx	Thyroid	U73166.2	0.05	0.02	enet	6	0.01	5.9e-02	-5.3	5.6	1.7e-08	-0.15	0.30	0.12	FALSE
33	GTEx	Uterus	NCKIPSD	0.13	0.10	lasso	4	0.22	2.6e-05	4.5	5.5	3.6e-08	-0.22	0.11	0.17	FALSE
34	METSIM	Adipose	CYB561D2	0.09	0.08	lasso	5	0.07	3.8e-10	-5.2	5.3	1.4e-07	-0.18	0.95	0.05	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	SEMA3F	0.07	0.11	bslmm	275	0.10	4.9e-13	-6.2	6.4	1.9e-10	-0.81	0.18	0.82	TRUE
36	ROSMAP	Brain Pre-frontal Cortex	CACNA2D2	0.05	0.02	lasso	3	0.02	3.6e-03	-5.1	5.2	2.1e-07	-0.17	0.42	0.06	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	SEMA3B	0.05	0.03	lasso	6	0.02	8.3e-04	-5.2	-5.1	2.9e-07	0.15	0.79	0.04	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	HEMK1	0.07	0.13	lasso	5	0.13	7.9e-16	-5.1	5.2	2.5e-07	-0.22	0.94	0.06	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	BSN	0.21	0.06	blup	337	0.13	1.4e-16	6.3	-7.7	1.1e-14	0.59	0.05	0.95	TRUE
40	ROSMAP	Brain Pre-frontal Cortex	SLC38A3	0.03	0.03	lasso	5	0.02	6.4e-04	-6.2	6.3	2.5e-10	-0.89	0.04	0.95	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CYB561D2	0.10	0.02	lasso	3	0.01	1.9e-02	-5.5	5.3	1.4e-07	-0.22	0.01	0.05	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	HEMK1	0.02	0.02	lasso	2	0.02	1.0e-04	-5.2	5.2	1.9e-07	-0.21	0.02	0.96	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM115	0.06	0.04	lasso	3	0.05	9.7e-04	-5.5	-6.2	7.0e-10	0.26	0.00	0.92	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf18	0.02	0.02	blup	28	0.02	8.1e-04	-5.0	-5.3	9.9e-08	0.21	0.02	0.90	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HEMK1	0.01	0.00	blup	29	0.01	1.6e-02	-5.2	5.4	6.7e-08	-0.21	0.01	0.81	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAPKAPK3	0.03	0.02	enet	32	0.02	3.0e-03	-4.6	-5.2	1.5e-07	0.21	0.02	0.77	FALSE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CYB561D2	0.16	0.07	enet	9	0.09	4.1e-05	-5.5	6.2	8.0e-10	-0.38	0.01	0.96	TRUE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYB561D2	0.08	0.07	lasso	2	0.09	1.7e-09	-5.5	5.7	1.5e-08	-0.21	0.37	0.63	FALSE
49	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CYB561D2	0.08	0.04	blup	17	0.08	9.3e-04	-5.2	5.5	3.0e-08	-0.17	0.01	0.69	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	HEMK1	0.06	0.08	lasso	2	0.07	1.3e-07	-5.1	5.1	3.1e-07	-0.20	0.02	0.98	FALSE