Hub : Genes

MAPKAPK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0850 0.0480 8.5e-04 0.000 NA 0.027 NA 0.005 3.2e-01 NA 6.1e-03 NA 1.4e-01
2 GTEx Testis 0.2540 0.1080 4.4e-03 -0.002 NA 0.025 NA 0.012 4.3e-01 NA 2.8e-02 NA 9.4e-02
3 GTEx Thyroid 0.4940 0.0830 4.0e-11 0.113 NA 0.188 NA 0.169 5.8e-09 NA 2.2e-14 NA 5.8e-13
4 GTEx Whole Blood 0.0820 0.0630 1.0e-03 0.037 NA 0.000 NA 0.012 2.2e-04 NA 3.6e-01 NA 2.4e-02
5 NTR Blood 0.0587 0.0186 3.2e-11 0.025 0.036 0.043 0.031 0.041 9.3e-09 8.2e-12 8.5e-14 3.1e-10 4.6e-13
6 YFS Blood 0.3004 0.0665 0.0e+00 0.027 0.112 0.123 0.112 0.097 1.9e-09 9.9e-35 3.5e-38 1.6e-34 5.0e-30
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0311 0.0221 2.8e-03 0.023 0.018 0.019 NA 0.018 1.1e-03 3.2e-03 3.0e-03 NA 3.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.0 1.5 3.2 1.0 -1.5 -1.8 -1.0 1.1 -1.3 0.7
Bipolar Disorder or Schizophrenia 0.5 1.1 2.7 0.7 -0.4 -1.6 -0.9 0.4 -1.5 1.2
Depressed Affect (Nagel 2018) 1.3 2.8 7.7 -0.3 0.0 2.7 -0.8 -1.6 -0.9 2.8
Depression (Nagel 2018) 1.6 2.4 7.1 -0.9 1.0 -0.1 -2.1 -1.7 -1.0 2.7
Intelligence (Savage-Jansen 2018) 1.6 4.8 17.9 0.8 1.2 -4.2 2.3 -1.3 0.5 -2.6
Neuroticism (Nagel 2018) 1.8 4.2 12.5 -1.1 2.1 2.0 -1.3 -2.3 -0.8 3.5
Schizophrenia (2018) 0.2 0.4 1.1 -0.0 0.4 -0.7 -0.3 -0.4 -0.7 1.1
Schizophrenia vs Biploar Disorder 0.9 1.2 2.5 -0.5 1.6 -0.9 1.5 -0.6 0.0 -1.4
Worry (Nagel 2018) 1.6 3.3 11.1 -0.3 3.3 1.1 -1.3 -0.6 -0.3 2.9
Alzheimer’s Disease (in mother) 0.7 0.8 2.3 1.1 -1.5 -0.9 -0.2 1.1 0.4 0.2
Alzheimer’s Disease (in father) 1.4 1.5 4.0 1.4 -1.0 -1.9 0.2 0.4 -0.2 -2.0
Alzheimer’s Disease (including proxy) 1.3 1.9 4.5 1.7 -2.1 -1.8 -0.5 1.3 0.2 -0.9
Crohns Disease (2017) 0.7 1.5 4.0 -0.8 0.9 -0.5 1.0 -1.8 -2.0 -0.8
Irritable Bowel Disease (IBD) 0.8 2.0 4.1 -0.2 2.0 -1.8 1.3 -1.6 -1.1 -1.2
Ulcerative Colitis (UC) 0.9 1.8 5.2 0.5 2.3 -2.0 1.3 -0.5 0.1 -1.0
Major Depression (MDD) 3.1 3.8 7.9 -2.1 1.6 1.8 -1.1 -2.8 -0.6 2.6
Reaction Time 1.2 2.4 6.8 1.2 0.2 -0.8 2.6 0.4 2.3 -1.5
Verbal and Numeric Reasoning (VNR) 1.5 3.5 7.1 2.0 0.8 -2.7 2.5 0.3 0.8 -2.4
Breast Cancer 1.3 3.1 9.2 0.6 0.0 -0.7 3.0 1.2 2.0 -2.5
Ovarian Cancer 0.4 0.6 1.7 -0.1 0.6 0.3 0.7 0.2 1.2 -1.3
Prostate Cancer 1.1 1.6 3.5 -0.1 -0.1 1.9 -1.8 -1.2 0.7 1.6
Age at First Birth 2.2 3.3 16.0 -1.1 1.1 -4.0 0.1 1.3 1.4 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.7 2.4 4.1 2.0 -1.7 0.8 2.0 1.1 1.4 -1.4
Coronary Artery Disease (CAD) 1.4 1.7 8.1 -0.8 0.2 2.8 0.2 -0.2 0.6 -1.7
Crohns Disease (2012) 0.4 0.6 2.2 0.9 0.9 -0.2 1.5 0.1 -0.3 -0.1
Mean Putamen Volume 0.6 0.7 2.0 -0.5 -0.0 -0.7 -1.4 1.0 -0.6 0.8
Fasting Glucose 0.8 1.0 2.2 -0.3 -0.7 0.5 1.5 -1.1 0.8 -1.4
HbA1C 2.1 2.3 5.5 1.2 -1.3 -2.0 0.6 1.8 -0.2 -2.4
HDL Cholesterol 0.4 0.7 1.7 -0.9 0.8 0.4 1.3 0.6 -0.7 -0.9
LDL Cholesterol 0.6 0.9 3.9 -0.5 -0.6 0.9 -0.5 -0.6 -2.0 0.6
Lupus 1.5 2.3 4.4 -1.5 -1.3 -0.6 -2.1 0.2 -2.0 1.7
Neuroticism (2016) 1.4 2.1 5.1 -2.3 1.0 0.6 -1.0 -2.1 0.0 1.6
Primary Biliary Cirrhosis 0.7 0.9 3.6 -0.0 -0.3 -1.9 0.1 0.2 0.2 -1.6
Rheumatoid Arthritis 0.7 1.0 2.5 1.2 -0.0 -0.9 1.6 0.8 0.1 -1.4
Schizophrenia (2014) 0.2 0.5 0.9 0.2 0.6 -0.8 -0.2 -0.8 -0.9 0.9
Triglycerides 1.6 2.6 5.4 -1.7 -1.2 -0.7 -2.3 -1.3 -1.8 1.6
Type 2 Diabetes (T2D) (2012) 1.4 1.7 5.9 -0.8 -2.4 -0.6 -0.5 0.9 -0.7 1.8
Ulcerative Colitis 1.3 1.9 5.1 1.0 2.1 -1.0 2.3 -0.2 0.6 -1.1
Blood Eosinophil Count 2.9 22.2 88.5 -0.7 -2.1 -2.6 -9.4 1.2 -5.1 5.2
Blood Platelet Count 0.2 2.7 6.6 1.4 -2.0 -0.4 2.6 -0.1 -1.0 -2.3
Blood Red Count 0.7 6.6 17.4 -1.9 1.6 1.1 -4.2 -1.4 -1.5 4.2
Blood White Count 0.9 6.8 18.1 -1.2 0.1 4.2 -2.8 -3.0 -1.3 3.1
Heel T-Score 0.7 5.3 13.9 -2.1 1.0 3.0 -2.5 -3.7 -0.6 1.5
BMI 3.2 18.3 35.0 5.9 -5.4 2.9 5.2 3.8 1.3 -3.4
Height 2.4 45.6 153.8 -4.5 3.3 -2.9 -12.4 -1.1 -7.5 8.3
Waist Hip Ratio (WHR) 1.8 8.0 20.4 -1.5 2.8 -1.8 -4.5 -2.2 -0.9 4.1
Systolic Blood Pressure 1.5 7.5 16.9 -1.7 0.8 1.3 -3.9 -0.0 -3.9 4.1
Smoking Status 1.1 2.7 17.3 0.6 -4.2 0.9 -0.0 0.2 -0.7 0.2
Allergy or Eczema 0.8 2.1 7.8 -0.5 1.8 -0.1 -2.8 1.3 -0.9 1.0
Cardiovascular Disease 0.4 1.4 3.6 -1.1 -0.1 1.9 -0.5 0.0 -1.2 1.8
Hypothyroidism (self reported) 0.7 1.6 5.5 -0.1 1.3 2.4 0.5 -0.4 0.8 1.7
Respiratory disease 1.4 3.0 6.7 1.6 -1.4 -0.3 -2.6 2.0 -0.6 2.3
Type 2 Diabetes (T2D) (2018) 0.7 1.2 4.5 -0.5 -2.1 0.1 -0.8 -1.4 -0.7 0.9
Lung FEV1/FVC ratio 0.5 2.6 7.7 0.1 -2.0 -2.8 -1.8 -1.5 -0.8 0.3
Lung FVC 2.2 11.2 25.6 3.5 -2.1 -1.7 5.1 3.3 3.2 -3.6
Neuroticism 1.3 3.2 11.9 -0.6 1.2 1.8 -0.7 -1.9 -0.9 3.5
Chronotype (morning person) 4.2 9.7 27.6 3.6 0.2 -0.9 4.4 2.5 0.7 -5.2
Hair Pigment 0.0 1.1 6.7 0.6 -0.7 -0.0 0.4 2.6 -0.1 -0.5
Tanning 0.1 1.6 6.0 -0.9 -0.8 2.4 -1.0 -0.9 -0.9 1.1
Hand grip strength (left) 0.4 1.0 3.4 -0.5 -1.8 0.4 -0.9 -0.4 -1.4 0.2
Number of treatments/medications taken 1.5 2.8 7.0 1.9 -0.3 2.2 -0.8 1.8 0.2 2.6
Average weekly spirits intake 0.6 0.7 1.3 0.2 0.9 0.8 -1.1 1.2 -0.3 0.9
Sensitivity / hurt feelings 1.0 1.8 4.2 -0.8 1.1 -0.4 -1.2 -2.0 -1.2 1.8
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.3 0.9 1.5 0.2 -1.4 -1.3 -0.1 1.8
Hearing difficulty/problems: Yes 0.3 0.4 2.0 1.4 0.3 -0.5 0.7 0.3 -0.2 0.2
Relative age of first facial hair 5.4 11.0 32.7 -2.6 -1.3 -0.3 -5.7 -1.7 -3.6 4.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 0.9 0.7 0.7 -0.5 1.0 0.8 0.6 0.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.6 0.2 -1.9 0.4 -1.3 0.4 0.1 0.9
Ever had hysterectomy (womb removed) 1.3 1.5 4.2 -1.2 -2.1 1.6 -1.0 -1.0 0.4 0.4
Systolic blood pressure, automated reading 0.7 1.9 7.3 0.1 0.0 1.7 -1.0 0.3 -2.7 1.4
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 4.4 1.2 0.5 -1.6 0.9 -0.2 2.1 -1.1
Angina 0.5 0.7 2.3 0.2 0.3 1.0 1.5 -0.3 1.0 -0.5
Medication for hormone replacement therapy 1.5 1.7 4.6 -0.9 -0.5 1.0 -2.1 -0.6 -0.7 2.1
Vitamin and mineral supplements 0.8 1.1 3.1 -0.2 -0.6 1.0 1.8 -0.9 0.9 -1.3
Supplements: Zinc 0.7 0.7 2.3 1.2 0.4 0.1 0.8 1.5 0.5 0.6
Medication: Co-codamol 1.4 1.6 7.6 0.1 -1.3 2.8 0.7 -0.9 0.6 0.7
Medication: Metformin 0.3 0.4 2.2 0.2 -1.5 -0.5 -0.0 -0.2 -0.7 0.2
Diabetes (father) 1.1 1.4 2.9 -0.8 -1.7 -1.4 -0.9 -1.6 0.3 0.8
Diabetes (mother) 1.3 1.7 3.7 -1.2 1.1 0.4 -1.9 -1.2 -1.4 1.5
Severe depression (siblings) 1.3 1.4 5.4 0.4 1.3 -0.4 -0.7 1.3 -0.5 2.3
Pack years adult smoking proportion 1.2 1.9 4.7 1.7 -0.4 2.2 1.9 1.1 0.5 0.4
Impedance of leg (right) 8.3 40.1 83.2 -8.3 5.9 -0.8 -9.1 -6.3 -3.9 6.2
Leg fat-free mass (left) 1.2 6.2 12.6 3.6 -3.4 2.4 1.6 3.2 0.5 -0.6
Trunk fat percentage 0.5 2.2 13.1 0.2 -0.6 3.6 -1.1 -0.2 -0.4 0.6
Hand grip strength (right) 0.8 2.1 4.8 -1.0 -2.0 1.0 -1.7 -0.1 -2.2 0.9
Townsend deprivation index at recruitment 1.9 2.6 7.7 -0.9 -0.1 2.8 -0.6 -1.7 -1.6 2.0
Current tobacco smoking 0.2 0.4 0.9 0.7 -1.0 0.9 0.2 -0.2 -0.4 -0.2
Average weekly fortified wine intake 0.7 0.8 2.2 -0.0 1.5 1.3 -0.4 0.9 0.0 0.9
Maternal smoking around birth 1.7 2.4 9.9 2.1 -3.1 -0.8 1.2 0.6 -0.5 -0.1
Fed-up feelings 1.8 3.3 10.7 -0.4 -0.2 3.3 -0.7 -2.4 -0.9 2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 6.4 -1.2 1.0 0.8 -2.2 -2.5 -1.2 2.5
Relative age voice broke 4.3 6.5 16.3 -2.4 -1.6 -1.3 -4.0 -1.7 -3.2 2.5
Taking other prescription medications 3.3 5.2 18.4 0.6 -0.2 2.2 -3.1 -0.1 -1.6 4.3
Age when periods started (menarche) 6.2 14.8 34.2 -3.5 -3.0 0.5 -5.8 -3.3 -4.1 4.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.9 0.3 -0.9 0.4 -0.5 0.0 -0.1 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.6 0.3 1.9 1.6 -1.5 1.2 -0.7 1.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.3 0.4 -0.4 0.1 -0.5 1.2 -0.4 -0.5
Qualifications: CSEs or equivalent 2.5 3.3 5.8 -2.2 -0.9 1.8 -2.4 -1.8 -1.6 1.6
Serious illness, injury or assault to yourself 0.8 0.9 2.1 1.2 0.3 0.8 0.9 1.5 1.1 0.1
High blood pressure 0.5 1.3 5.7 0.5 -0.5 1.0 -0.4 2.4 -0.2 1.4
Hayfever, allergic rhinitis or eczema 1.0 2.2 7.6 -0.5 2.4 -0.2 -2.8 1.0 -0.2 0.8
Multivitamins +/- minerals 1.1 1.4 3.9 -0.1 0.1 -0.8 -2.0 1.1 -1.6 1.2
Stomach or abdominal pain in last month 4.0 4.9 10.4 -2.4 1.1 2.7 -1.5 -2.8 -0.1 3.2
Supplements: Glucosamine 0.3 0.4 1.3 -0.4 -0.2 0.3 -0.9 1.1 -0.7 0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 0.1 0.7 0.9 -0.2 -1.0 0.9 0.4
Medication: Atenolol 1.0 1.3 3.2 -0.5 -1.0 1.2 -0.8 1.4 0.5 1.8
Medication: Levothyroxine sodium 0.4 0.6 1.5 0.8 0.1 0.4 0.9 0.8 1.2 0.8
Sitting height 0.6 3.9 17.0 -0.9 -0.6 0.1 -4.1 0.3 -1.9 2.3
Chronic bronchitis/emphysema (father) 1.3 1.6 3.8 -0.2 -1.1 0.7 -1.1 -1.4 -1.9 1.6
High blood pressure (mother) 0.8 1.1 3.9 0.0 2.0 1.3 0.0 1.0 -0.5 1.0
Body mass index (BMI) 3.1 13.1 20.2 4.4 -4.5 4.1 4.5 3.0 1.5 -2.0
Impedance of leg (left) 7.5 36.7 72.6 -7.9 6.1 -1.0 -8.5 -5.9 -3.9 5.8
Leg predicted mass (left) 1.2 6.1 12.0 3.5 -3.5 2.3 1.5 3.2 0.5 -0.6
Trunk fat mass 0.6 2.6 12.8 1.0 -1.5 3.6 -0.9 0.7 -0.6 0.9
Waist circumference 0.5 1.9 4.5 1.8 -2.1 2.1 0.9 0.7 0.2 0.2
Number of incorrect matches in round 2.5 4.1 8.1 2.1 1.2 2.0 2.3 2.9 1.8 -1.5
Past tobacco smoking 2.1 3.8 18.2 0.1 4.3 0.5 1.2 0.0 1.9 -1.7
Alcohol usually taken with meals 0.5 0.8 2.8 -0.1 0.8 -1.4 -0.4 1.7 0.1 -0.5
Nervous feelings 0.9 1.7 4.9 0.2 2.2 -1.5 -1.4 0.8 -0.6 1.3
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 6.4 0.4 0.9 2.2 -1.4 -2.0 -0.0 2.5
Hearing difficulty/problems with background noise 0.7 1.1 2.6 -1.4 -0.8 -1.1 0.5 -1.6 -0.8 -0.7
Hair/balding pattern: Pattern 2 0.5 0.6 1.6 0.7 0.4 0.5 -0.7 -0.2 1.0 1.3
Had menopause 2.8 3.4 7.3 2.7 -0.5 -1.0 2.5 1.9 1.8 -1.6
Had other major operations 0.4 0.5 1.7 0.0 -0.3 1.3 0.0 0.1 0.5 1.3
Forced vital capacity (FVC) 0.3 1.3 3.7 0.4 -0.3 -1.9 -0.3 1.9 0.7 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.6 -0.3 1.6 0.9 -1.2 1.0 0.1 0.4
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 8.2 -0.8 0.3 0.5 -1.8 -2.9 -1.3 2.4
Qualifications: None of the above 2.1 4.6 15.8 -0.8 -4.0 1.7 -1.5 -0.5 -2.5 2.0
Financial difficulties in last 2 years 1.8 2.4 7.2 -2.1 0.7 1.1 -1.6 -2.7 -0.5 0.8
Mouth/teeth dental problems 2.4 3.6 10.7 -0.2 1.1 -2.0 1.9 -0.4 2.4 -3.3
Heart attack 1.0 1.3 7.0 0.3 -0.2 2.7 1.1 -0.1 -0.4 0.4
Allergy 1.4 3.1 8.9 -1.1 -1.0 0.6 3.0 -2.9 0.5 -1.2
Pain all over the body in last month 0.9 0.9 4.2 0.4 -2.0 0.3 0.4 -1.1 0.7 0.6
Diabetes (self-reported) 0.2 0.3 0.9 0.6 -0.9 -0.3 0.2 -0.6 0.1 0.5
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 5.7 -0.9 0.5 -1.1 -2.4 0.6 -1.3 0.7
Medication: Ramipril 0.9 1.1 2.6 1.6 -1.1 0.6 1.1 1.5 0.2 0.6
Medication: Simvastatin 0.3 0.5 1.0 0.7 -0.9 0.9 1.0 0.2 0.2 -0.2
Fluid intelligence score 0.7 1.5 6.6 0.3 0.7 -2.6 0.8 0.1 -0.3 -1.6
Illnesses of siblings 1.6 2.3 7.9 -0.4 -1.5 -2.3 0.6 -0.1 0.4 -2.8
Neuroticism score 1.5 3.1 8.8 -0.0 1.9 1.7 -1.1 -2.0 -1.2 3.0
Weight 0.9 4.6 10.2 2.6 -3.2 3.0 0.4 2.3 -0.6 0.6
Impedance of arm (right) 4.6 21.5 42.2 -6.0 6.2 -2.6 -6.5 -4.7 -1.4 1.9
Arm fat percentage (right) 1.0 4.1 11.6 2.1 -1.8 3.4 2.1 1.1 1.4 -1.4
Trunk fat-free mass 0.7 4.2 9.4 2.4 -3.1 1.6 0.1 2.8 -1.2 1.6
Hip circumference 0.9 3.7 8.6 1.8 -2.9 2.7 1.9 1.4 0.4 -1.1
Time employed in main current job 4.1 4.8 14.1 2.1 0.6 -0.1 3.8 0.3 2.1 -3.2
Alcohol intake versus 10 years previously 1.2 1.9 6.2 -0.4 -0.8 1.2 -2.5 -1.1 -1.0 1.5
Father’s age at death 0.4 0.6 2.9 0.0 -0.5 -1.7 0.4 -0.8 -0.1 -0.3
Worrier / anxious feelings 1.5 2.9 14.3 0.7 3.8 2.1 0.2 -0.2 0.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 10.2 -2.4 1.6 1.9 -1.7 -1.9 -1.2 3.2
Falls in the last year 0.8 1.1 2.0 1.0 -1.4 -0.5 1.4 1.1 1.2 -0.4
Hair/balding pattern: Pattern 3 0.7 1.0 4.1 -2.0 0.0 -0.9 -0.0 0.0 -0.8 -1.2
Number of live births 1.2 1.7 7.6 1.3 -2.8 0.9 -0.1 0.2 -1.1 0.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 5.2 0.1 -0.6 -2.3 -0.7 1.0 1.1 1.2
Pulse rate 0.7 1.2 3.7 -0.8 1.4 -0.1 -0.7 -1.9 1.1 0.2
Happiness 1.1 1.4 4.7 -0.2 2.2 0.8 -0.7 -1.0 -0.9 1.3
Noisy workplace 0.3 0.4 1.0 0.9 -0.4 0.5 0.1 -0.6 0.0 1.0
Qualifications: A levels/AS levels or equivalent 1.7 3.7 7.6 2.1 2.8 -2.2 1.7 0.8 1.8 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.6 -0.1 -0.0 1.3 0.9 0.5 -0.4 -0.4
Mouth/teeth dental problems: Dentures 1.6 2.7 5.7 2.4 -1.3 2.1 -0.3 2.0 -1.6 0.5
Asthma 1.5 2.9 6.7 1.9 -0.1 0.4 -2.3 2.6 -0.3 2.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.3 0.9 0.1 1.5 -0.2 1.3 0.2 1.3
Medication: Cholesterol lowering 0.4 0.6 2.0 0.3 -0.8 1.4 0.7 0.7 -0.3 -0.1
Depression (self-reported) 1.1 1.3 2.2 1.5 1.4 1.2 0.5 0.6 1.0 1.2
Medication: Lansoprazole 1.0 1.2 5.9 -0.0 0.3 2.4 0.3 -0.6 0.9 1.0
Prospective memory result 1.2 1.5 5.4 1.6 0.8 2.3 -0.1 0.8 0.9 0.6
Lung cancer (father) 1.0 1.2 5.2 0.1 -1.7 0.4 -0.2 -2.3 0.5 0.0
Illnesses of mother 1.8 2.2 7.1 0.3 -0.9 -1.4 1.4 0.0 1.9 -2.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 6.3 0.6 -1.0 -2.5 -0.4 1.4 0.8 0.6
Pulse wave Arterial Stiffness index 0.9 1.0 3.7 -1.0 -0.5 0.5 -1.2 0.0 -0.6 1.9
Impedance of arm (left) 4.3 19.8 39.8 -6.0 5.4 -2.8 -6.3 -4.7 -1.5 1.4
Arm fat mass (right) 1.3 5.4 15.2 2.6 -2.7 3.9 1.9 1.9 0.8 -0.6
Trunk predicted mass 0.7 4.1 8.4 2.4 -2.9 1.7 0.1 2.8 -1.2 1.6
Standing height 2.0 19.4 69.1 -3.3 1.6 -2.2 -8.3 -0.8 -4.5 5.3
Length of working week for main job 2.1 2.4 7.8 0.2 0.3 2.7 2.8 0.5 0.9 -0.4
Exposure to tobacco smoke at home 0.4 0.5 1.8 0.9 -1.4 0.4 0.1 -0.2 -0.7 0.4
Breastfed as a baby 1.9 2.4 7.3 0.3 -2.7 -2.1 0.3 1.3 0.4 -1.7
Tense / ‘highly strung’ 2.0 3.3 9.8 -0.9 2.0 2.2 -1.4 -1.3 -0.4 3.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.2 7.4 1.3 1.2 1.8 -1.0 -0.6 -0.4 2.7
Hair/balding pattern: Pattern 4 0.4 1.0 3.7 -0.3 -1.3 0.9 -0.6 0.7 -1.9 0.5
Birth weight of first child 3.4 6.2 13.2 3.6 -1.6 -2.6 2.4 2.3 0.7 -3.0
Peak expiratory flow (PEF) 0.4 1.0 3.4 0.2 -1.8 -1.4 -0.6 0.4 -0.4 0.7
Pulse wave reflection index 1.0 1.2 3.2 1.2 -1.8 0.0 1.0 1.6 -0.5 0.0
Ever highly irritable/argumentative for 2 days 4.6 5.5 10.4 -1.6 -0.3 2.2 -2.8 -2.1 -2.9 3.2
Loud music exposure frequency 0.3 0.3 1.0 -0.0 0.4 -0.6 0.1 -1.0 -0.2 0.6
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 4.1 1.4 2.0 -0.9 0.3 -0.1 1.4 -0.3
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 4.5 -1.9 0.1 -1.0 -1.4 -1.9 -2.1 1.6
Blood clot in the leg (DVT) 0.6 0.8 2.3 0.8 -1.5 -1.1 0.6 -0.3 1.0 -0.4
Medication: Paracetamol 1.8 3.0 7.2 2.7 -1.5 -0.1 1.8 2.2 1.5 -0.9
Headache pain in last month 0.2 0.3 1.1 0.4 0.3 0.9 0.2 -0.1 -0.0 1.0
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 4.9 -0.9 1.0 -2.2 -0.5 -0.7 0.1 -0.6
Glaucoma (self-reported) 1.4 1.6 6.0 -1.3 2.4 0.6 -0.3 -1.7 -0.6 0.5
Gout (self-reported) 0.7 1.0 2.1 0.0 0.8 1.4 -0.7 -1.2 -0.6 1.5
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.6 1.0 0.9 1.6 1.5 0.9 1.6 0.8
Medication: Amlodipine 0.3 0.5 0.9 0.7 -0.1 1.0 0.0 0.8 -0.8 0.8
Medication: Ventolin 100micrograms inhaler 1.6 2.1 5.6 0.9 -0.7 0.5 -2.4 0.8 -1.3 2.2
Birth weight 0.7 1.4 3.1 1.6 -1.8 -1.1 0.8 1.2 0.3 -1.0
Chronic bronchitis/emphysema (mother) 0.9 1.0 3.3 0.4 -1.0 1.3 -0.8 0.4 -0.4 1.8
High blood pressure (siblings) 1.1 1.6 7.2 0.3 0.0 0.8 -1.2 0.8 -1.1 2.7
Forced vital capacity (FVC), Best measure 0.5 1.8 5.4 1.0 -0.5 -2.3 -0.3 2.3 0.3 0.6
Body fat percentage 0.6 2.5 15.4 0.4 -1.1 3.9 -0.5 -0.2 -0.2 0.5
Leg fat percentage (right) 0.9 3.3 18.4 0.2 -1.6 4.3 -0.2 -0.2 -0.4 1.2
Arm fat-free mass (right) 1.1 5.4 12.1 2.5 -3.5 2.9 0.4 2.8 -0.9 1.5
Exposure to tobacco smoke outside home 1.6 2.1 5.2 1.8 -1.9 2.3 1.3 0.7 -0.6 0.3
Comparative body size at age 10 4.1 11.4 20.6 4.1 -4.5 -2.0 3.9 3.1 0.6 -3.6
Number of full brothers 0.5 0.6 1.9 1.1 -1.4 0.2 0.9 0.4 0.3 -0.2
Worry too long after embarrassment 0.8 1.3 3.5 -0.4 1.1 -1.7 1.0 -1.9 -0.0 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.2 2.4 1.2 1.6 1.3 -0.1 -0.7 0.8 1.4
Wheeze or whistling in the chest in last year 2.2 3.8 8.5 0.7 0.6 2.9 -2.5 1.4 -1.1 2.9
Number of children fathered 0.6 0.6 1.2 -0.0 -0.9 1.1 -1.1 -0.5 -0.8 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 2.0 1.4 1.3 0.7 0.8 1.4 1.0 -0.3
Age at first live birth 5.5 9.7 32.1 1.3 0.0 -5.7 1.9 2.2 1.8 -4.8
Pulse wave peak to peak time 0.6 0.7 2.8 0.6 0.8 -0.4 0.7 -0.2 0.4 -1.7
Health satisfaction 2.5 3.3 11.4 -0.2 1.6 2.0 -2.0 0.0 -0.9 3.4
Shortness of breath walking on level ground 0.9 1.1 3.2 -0.1 0.3 1.8 -1.2 -0.3 0.6 1.5
Qualifications: College or University degree 3.3 10.3 26.1 2.2 5.1 -2.5 3.8 1.1 3.5 -2.6
Eye problems/disorders: None of the above 0.7 0.8 2.2 -0.9 -1.5 0.8 0.4 0.1 -0.9 -1.1
Mouth/teeth dental problems: Loose teeth 2.7 3.2 7.5 -1.1 -1.4 2.2 -1.3 -1.3 -1.8 2.7
Emphysema/chronic bronchitis 1.2 1.4 3.3 1.1 -1.5 -0.7 0.4 1.8 -0.9 1.1
Medication for pain relief, constipation, heartburn 2.0 3.4 9.5 -3.1 0.6 -1.3 -1.7 -2.8 -0.8 -0.9
Neck or shoulder pain in last month 2.4 3.4 7.2 -1.5 -2.2 -0.2 -1.7 -1.8 -2.7 1.7
Medication: Blood pressure 1.1 2.0 4.2 2.0 -0.7 2.1 0.5 1.8 0.3 1.3
Angina (self-reported) 0.9 1.2 3.8 0.1 0.6 1.6 2.0 -0.4 1.1 -0.6
Migraine (self-reported) 0.8 1.0 3.2 -0.4 -0.8 0.4 -0.6 -1.2 -0.9 1.8
Medication: Ibuprofen 0.8 0.9 2.8 0.3 0.4 1.7 -0.2 0.6 -0.6 1.6
Medication: Allopurinol 0.2 0.3 1.3 0.6 1.2 0.1 0.3 -0.0 0.2 0.3
Medication: Omeprazole 0.7 0.9 3.0 0.4 -0.9 1.1 -0.3 0.5 0.7 1.7
Medication: Seretide 50 evohaler 1.0 1.1 3.0 1.7 -0.9 0.3 -0.6 1.7 0.7 0.6
Mean time to correctly identify matches 1.4 2.7 7.6 1.2 -0.0 -0.6 2.8 1.1 2.3 -1.6
Heart disease (mother) 0.4 0.5 1.6 0.6 0.8 0.4 0.1 1.3 -0.8 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.5 -0.2 0.6 -0.5 -0.6 -0.6 -1.2 0.7
Whole body fat mass 0.8 3.4 15.4 1.4 -2.2 3.9 -0.1 1.0 -0.3 0.6
Leg fat mass (right) 1.1 4.1 17.8 1.5 -2.6 4.2 0.4 1.1 -0.2 0.8
Arm predicted mass (right) 1.0 5.3 11.6 2.7 -3.4 2.8 0.6 2.8 -0.8 1.3
Pulse rate, automated reading 1.1 3.5 8.0 -1.4 2.1 2.2 -1.9 -2.8 0.1 1.1
Alcohol intake frequency. 0.7 1.7 5.0 0.4 -1.1 1.4 -1.6 0.0 -0.9 2.2
Comparative height size at age 10 0.2 1.1 3.3 -0.3 1.1 -1.2 -1.8 1.1 -0.9 0.2
Number of full sisters 3.6 4.4 10.0 -1.7 -0.3 2.0 -1.1 -3.2 -1.7 3.0
Suffer from ‘nerves’ 1.4 2.2 4.6 2.1 2.1 0.1 1.4 1.9 0.9 -0.0
Overall health rating 3.4 7.4 21.5 -0.5 0.1 4.1 -2.7 -1.6 -1.8 4.6
Chest pain or discomfort 1.0 1.4 4.1 -1.2 0.2 2.0 -1.3 0.5 -0.8 1.3
Had major operations 1.1 1.3 3.7 0.8 -1.6 -1.9 -0.3 1.0 -0.9 0.3
Age at last live birth 4.8 7.0 19.5 1.1 -0.3 -4.4 2.1 1.8 1.0 -4.4
Family relationship satisfaction 3.9 4.8 8.1 -2.4 1.7 2.2 -2.4 -2.3 -1.0 2.8
Leg pain on walking 4.3 5.3 14.0 -1.6 0.1 3.1 -2.8 -1.4 -1.3 3.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.0 -0.4 0.5 1.4 -0.7 -0.8 0.2 1.0
Commuting to job workplace: Car/motor vehicle 1.4 1.6 5.8 -0.8 -0.9 0.6 -1.2 -0.3 -2.4 1.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.8 0.4 -0.2 -0.0 0.0 -0.5 0.0 0.9
Medication: Aspirin 0.4 0.5 1.9 0.8 -0.2 0.8 0.6 1.4 -0.5 0.2
Supplements: Vitamin C 0.3 0.3 1.0 -0.8 -0.0 -0.1 -1.0 -0.7 -0.3 0.3
Knee pain experienced in last month 1.5 2.3 6.5 -0.4 -0.6 2.5 -1.3 0.2 -1.1 2.5
Hypertension (Self-reported) 0.6 1.7 8.3 1.1 -0.1 0.8 0.2 2.9 -0.1 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 4.1 -1.6 -1.1 1.3 -1.4 -0.3 -0.8 2.0
Illnesses of father: Heart disease 0.4 0.5 1.1 -0.4 0.7 0.8 0.0 0.6 -1.0 1.0
Illnesses of siblings: Diabetes 1.6 1.9 4.5 -0.8 -0.8 0.2 -2.1 -1.7 -0.7 2.0
Smoking status: Previous 3.0 4.5 20.8 -0.4 -4.6 -0.5 -1.3 0.8 -2.3 1.5
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.5 12.9 -0.7 1.2 0.4 -3.6 0.6 -1.9 3.6
Whole body fat-free mass 0.9 5.2 10.2 3.1 -3.2 2.2 0.8 3.2 -0.6 0.9
Leg fat-free mass (right) 1.3 6.7 15.0 3.9 -3.2 2.0 2.0 3.5 0.7 -1.0
Arm fat percentage (left) 1.1 4.3 12.3 2.0 -2.1 3.5 2.0 1.0 1.3 -1.6
Average weekly red wine intake 1.4 2.0 5.0 2.2 0.3 -0.9 1.1 2.1 -0.1 -1.6
Handedness (chirality/laterality): Left-handed 1.8 2.1 5.3 0.7 -0.3 -2.3 1.9 0.8 0.4 -2.2
Mood swings 1.9 3.5 10.1 0.6 2.0 3.2 -0.6 -1.9 -0.3 2.5
Loneliness, isolation 1.2 1.7 5.0 -0.2 0.8 1.8 -1.2 0.3 -1.1 2.2
Long-standing illness, disability or infirmity 0.7 1.0 3.2 1.5 -0.7 0.9 0.3 0.5 0.2 1.8
Ever had bowel cancer screening 0.7 0.8 2.2 -1.2 1.5 0.1 -0.4 0.3 -1.0 1.0
Diabetes diagnosed by doctor 0.1 0.2 0.6 0.6 -0.8 -0.2 0.1 -0.3 0.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.2 -0.0 -0.6 -0.2 0.3 -1.1 -0.5 -0.3
Friendships satisfaction 2.3 2.9 6.0 -2.1 2.3 0.2 -1.8 -2.4 -0.3 1.1
Qualifications: nursing, teaching 2.2 3.4 5.5 1.7 1.9 -1.2 2.2 0.9 2.4 -2.1
Commuting to job workplace: Walk 1.6 1.7 3.5 0.9 0.8 -0.2 1.8 1.0 1.9 -1.7
Eye problems/disorders: Cataract 0.9 1.1 4.0 1.0 -0.6 -2.0 0.7 0.4 1.2 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.3 -0.8 -0.3 0.3 -1.8 -0.6 -0.7 1.6
Medication for cholesterol 1.1 1.7 7.0 0.4 1.1 -0.8 1.5 -0.7 0.2 -2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 5.4 -0.3 1.8 1.9 -1.2 -0.1 -0.6 2.3
Back pain experienced in last month 3.7 5.3 10.7 -2.1 1.4 3.3 -2.0 -2.1 -1.2 3.2
Mineral and other dietary supplements 0.4 0.6 2.0 1.4 -0.0 -0.7 0.6 0.1 0.8 -0.8
Breast cancer (self-reported) 0.7 0.8 3.7 -0.7 -1.9 -0.4 -0.4 -1.0 -0.3 0.2
Asthma (self-reported) 1.5 3.0 7.1 2.0 -0.2 0.3 -2.3 2.7 -0.1 2.0
Osteoporosis (self-reported) 0.3 0.4 1.1 0.7 -0.3 0.6 0.6 0.1 1.1 0.0
Osteoarthritis (self-reported) 1.3 1.7 4.5 1.3 -0.4 2.0 0.5 2.1 0.9 0.5
Medication: Aspirin 0.5 0.7 2.4 0.8 -0.4 0.6 0.5 1.6 -0.8 0.6
Medication: Gliclazide 0.6 0.7 2.4 -1.3 0.1 0.5 -0.4 -1.6 -0.0 0.7
Illnesses of father: None of the above (group 1) 0.8 1.0 2.9 0.3 -0.6 0.7 1.3 -1.3 1.7 -0.0
Smoking status: Current 0.2 0.3 0.9 1.0 -0.6 0.7 0.3 -0.4 0.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.2 8.0 2.1 -0.7 -1.8 2.8 2.0 2.2 -2.0
Whole body water mass 0.9 5.4 10.7 3.2 -3.2 2.3 1.0 3.3 -0.4 0.8
Leg predicted mass (right) 1.3 6.9 15.3 3.9 -3.3 2.0 2.1 3.5 0.7 -1.0
Arm fat mass (left) 1.3 5.5 13.5 2.6 -3.0 3.7 1.9 2.0 0.8 -0.9
Number of self-reported non-cancer illnesses 1.1 1.9 8.1 0.5 -0.4 0.7 -1.5 1.5 -0.3 2.8
Average weekly champagne plus white wine intake 0.4 0.6 1.3 -1.0 1.1 -0.6 -0.3 -0.7 0.7 -0.4
Miserableness 1.5 2.6 7.4 0.3 -0.4 2.6 -0.3 -1.8 -0.0 2.7
Guilty feelings 0.6 0.8 2.2 0.3 -0.3 1.3 -0.2 0.2 -1.2 1.5
Wears glasses or contact lenses 0.5 0.6 1.2 -0.3 -1.1 -0.2 -1.0 -1.1 -0.8 0.4
Ever taken oral contraceptive pill 1.3 1.5 3.1 -1.8 0.1 1.4 -1.3 -1.4 -0.5 1.1
Hearing aid user 0.9 1.0 3.1 0.7 0.7 1.8 0.1 -1.1 -0.2 1.3
Mother’s age at death 1.3 1.7 4.8 1.2 0.6 -2.2 0.5 2.0 0.7 -0.3
Financial situation satisfaction 1.4 1.8 4.1 -1.2 0.0 0.8 -2.0 -1.2 -1.4 1.7
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.4 1.2 0.7 -0.1 0.2 0.6 1.2 0.3
Commuting to job workplace: Public transport 3.6 4.3 10.6 1.3 -0.2 -1.3 2.7 0.2 2.9 -3.2
Eye problems/disorders: Glaucoma 2.2 2.6 13.3 0.1 3.6 1.6 -0.1 -1.1 0.1 0.9
Medication: Blood pressure 0.9 1.7 5.6 0.3 0.3 0.8 -0.7 2.2 -0.5 2.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 5.4 -0.4 -0.1 2.2 -1.3 -0.1 -1.4 2.3
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.6 -0.8 0.7 1.3 -0.6 0.1 -0.6 0.9
High cholesterol (Self-reported) 0.6 1.1 3.5 0.0 -0.9 1.4 1.9 0.7 -0.2 -1.0
Medication: Bendroflumethiazide 0.6 1.0 3.2 -0.3 0.1 1.8 0.1 0.6 0.1 1.7
Medication: Paracetamol 1.1 1.8 5.5 2.3 -0.6 0.7 1.3 1.6 1.2 -0.1
Medication: Lisinopril 0.9 1.2 3.8 1.1 -0.2 0.7 -0.8 2.0 1.1 0.9
Medication: Atorvastatin 1.2 1.5 3.1 1.0 -1.8 -1.7 1.3 0.8 0.3 -0.9
Illnesses of father: High blood pressure 1.0 1.2 3.5 -0.3 0.7 -1.0 -1.9 0.6 -1.0 1.4
Alcohol drinker status: Never 0.5 0.6 2.4 1.6 -0.2 -0.1 0.7 0.9 0.6 0.4
Ever smoked 1.2 2.0 6.0 -0.3 -2.4 0.2 -1.3 -0.4 -1.3 2.2
Basal metabolic rate 0.9 5.1 9.9 2.9 -3.1 2.6 0.7 3.0 -0.4 0.9
Leg fat percentage (left) 0.8 2.9 16.7 0.8 -1.6 4.1 0.4 0.2 -0.3 0.6
Arm fat-free mass (left) 1.1 5.4 9.6 2.8 -3.1 3.0 0.6 2.8 -0.7 1.6
Number of operations (self-reported) 0.7 1.0 3.0 0.2 -1.6 1.2 -0.6 0.1 0.3 1.7
Average weekly beer plus cider intake 1.4 2.0 8.9 -0.4 -3.0 0.8 -0.8 -1.5 -0.8 0.9
Irritability 1.2 1.9 4.8 0.5 1.5 1.2 -0.1 -2.1 -0.6 2.2
Risk taking 2.2 3.2 5.3 -1.4 0.2 1.5 -2.1 -2.3 -1.8 2.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.7 0.9 0.5 -0.1 -0.6 1.6 -0.4 0.9
Fractured/broken bones in last 5 years 0.5 0.6 1.3 0.1 -0.0 -1.1 0.8 1.0 0.5 -1.1
Age started oral contraceptive pill 1.4 1.8 3.2 0.7 -0.5 -1.8 1.7 0.7 1.4 -1.8
Diastolic blood pressure, automated reading 1.2 3.7 10.8 0.1 0.3 3.3 -1.7 0.4 -1.2 3.2
Ever depressed for a whole week 3.0 3.6 8.2 -1.3 0.2 0.8 -2.5 -2.2 -1.9 2.9
Unable to work because of sickness or disability 0.9 1.2 3.3 1.1 -0.8 -0.4 1.5 -1.0 1.8 -0.2
Commuting to job workplace: Cycle 2.6 3.1 6.1 2.5 -0.7 -2.2 1.6 0.8 1.5 -2.3
Myopia 0.4 0.6 2.1 -0.5 -0.7 -0.5 0.1 0.2 0.8 -1.5
Vascular/heart problems diagnosed by doctor 0.5 1.2 4.7 -0.8 0.5 -1.2 -0.0 -2.2 0.3 -1.2
Cholesterol lowering medication 0.5 0.8 2.8 0.8 -1.7 0.5 1.3 -0.3 0.3 0.1
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.9 0.7 -0.4 1.7 0.4 0.2 1.3 1.5
Pain experienced in last month 3.0 5.0 14.1 0.9 1.1 -2.9 1.8 1.4 2.2 -3.8
Supplements: Calcium 0.6 0.6 2.7 -1.6 0.7 0.7 -0.7 -0.0 0.3 0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 0.0 -0.4 -0.4 -0.2 0.6 -0.4 -0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.1 6.3 0.3 -0.2 2.5 1.1 -0.0 -0.5 0.4
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.1 1.2 -1.4 -1.3 0.8 0.1 1.1 -0.7
Heart disease (siblings) 0.8 1.0 3.4 -0.3 1.3 1.8 0.3 -1.3 0.3 0.6
Alcohol drinker status: Previous 2.5 2.8 7.2 1.5 -1.7 0.3 2.7 0.2 1.8 -2.0
Pack years of smoking 1.4 2.0 4.4 2.1 -0.7 1.4 2.1 1.7 0.2 0.3
Impedance of whole body 6.5 32.9 70.2 -7.6 6.3 -2.2 -8.4 -5.8 -3.0 3.8
Leg fat mass (left) 1.1 4.4 16.7 2.0 -2.7 4.1 0.8 1.5 -0.2 0.5
Arm predicted mass (left) 1.1 5.4 10.0 3.0 -3.2 3.0 0.6 2.7 -0.7 1.4