Hub : Genes

MAPKAPK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0850	0.0480	8.5e-04	0.000	NA	0.027	NA	0.005	3.2e-01	NA	6.1e-03	NA	1.4e-01
2	GTEx	Testis	0.2540	0.1080	4.4e-03	-0.002	NA	0.025	NA	0.012	4.3e-01	NA	2.8e-02	NA	9.4e-02
3	GTEx	Thyroid	0.4940	0.0830	4.0e-11	0.113	NA	0.188	NA	0.169	5.8e-09	NA	2.2e-14	NA	5.8e-13
4	GTEx	Whole Blood	0.0820	0.0630	1.0e-03	0.037	NA	0.000	NA	0.012	2.2e-04	NA	3.6e-01	NA	2.4e-02
5	NTR	Blood	0.0587	0.0186	3.2e-11	0.025	0.036	0.043	0.031	0.041	9.3e-09	8.2e-12	8.5e-14	3.1e-10	4.6e-13
6	YFS	Blood	0.3004	0.0665	0.0e+00	0.027	0.112	0.123	0.112	0.097	1.9e-09	9.9e-35	3.5e-38	1.6e-34	5.0e-30
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0311	0.0221	2.8e-03	0.023	0.018	0.019	NA	0.018	1.1e-03	3.2e-03	3.0e-03	NA	3.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.0	1.5	3.2	1.0	-1.5	-1.8	-1.0	1.1	-1.3	0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	2.7	0.7	-0.4	-1.6	-0.9	0.4	-1.5	1.2
Depressed Affect (Nagel 2018)	1.3	2.8	7.7	-0.3	0.0	2.7	-0.8	-1.6	-0.9	2.8
Depression (Nagel 2018)	1.6	2.4	7.1	-0.9	1.0	-0.1	-2.1	-1.7	-1.0	2.7
Intelligence (Savage-Jansen 2018)	1.6	4.8	17.9	0.8	1.2	-4.2	2.3	-1.3	0.5	-2.6
Neuroticism (Nagel 2018)	1.8	4.2	12.5	-1.1	2.1	2.0	-1.3	-2.3	-0.8	3.5
Schizophrenia (2018)	0.2	0.4	1.1	-0.0	0.4	-0.7	-0.3	-0.4	-0.7	1.1
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	-0.5	1.6	-0.9	1.5	-0.6	0.0	-1.4
Worry (Nagel 2018)	1.6	3.3	11.1	-0.3	3.3	1.1	-1.3	-0.6	-0.3	2.9
Alzheimer’s Disease (in mother)	0.7	0.8	2.3	1.1	-1.5	-0.9	-0.2	1.1	0.4	0.2
Alzheimer’s Disease (in father)	1.4	1.5	4.0	1.4	-1.0	-1.9	0.2	0.4	-0.2	-2.0
Alzheimer’s Disease (including proxy)	1.3	1.9	4.5	1.7	-2.1	-1.8	-0.5	1.3	0.2	-0.9
Crohns Disease (2017)	0.7	1.5	4.0	-0.8	0.9	-0.5	1.0	-1.8	-2.0	-0.8
Irritable Bowel Disease (IBD)	0.8	2.0	4.1	-0.2	2.0	-1.8	1.3	-1.6	-1.1	-1.2
Ulcerative Colitis (UC)	0.9	1.8	5.2	0.5	2.3	-2.0	1.3	-0.5	0.1	-1.0
Major Depression (MDD)	3.1	3.8	7.9	-2.1	1.6	1.8	-1.1	-2.8	-0.6	2.6
Reaction Time	1.2	2.4	6.8	1.2	0.2	-0.8	2.6	0.4	2.3	-1.5
Verbal and Numeric Reasoning (VNR)	1.5	3.5	7.1	2.0	0.8	-2.7	2.5	0.3	0.8	-2.4
Breast Cancer	1.3	3.1	9.2	0.6	0.0	-0.7	3.0	1.2	2.0	-2.5
Ovarian Cancer	0.4	0.6	1.7	-0.1	0.6	0.3	0.7	0.2	1.2	-1.3
Prostate Cancer	1.1	1.6	3.5	-0.1	-0.1	1.9	-1.8	-1.2	0.7	1.6
Age at First Birth	2.2	3.3	16.0	-1.1	1.1	-4.0	0.1	1.3	1.4	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.7	2.4	4.1	2.0	-1.7	0.8	2.0	1.1	1.4	-1.4
Coronary Artery Disease (CAD)	1.4	1.7	8.1	-0.8	0.2	2.8	0.2	-0.2	0.6	-1.7
Crohns Disease (2012)	0.4	0.6	2.2	0.9	0.9	-0.2	1.5	0.1	-0.3	-0.1
Mean Putamen Volume	0.6	0.7	2.0	-0.5	-0.0	-0.7	-1.4	1.0	-0.6	0.8
Fasting Glucose	0.8	1.0	2.2	-0.3	-0.7	0.5	1.5	-1.1	0.8	-1.4
HbA1C	2.1	2.3	5.5	1.2	-1.3	-2.0	0.6	1.8	-0.2	-2.4
HDL Cholesterol	0.4	0.7	1.7	-0.9	0.8	0.4	1.3	0.6	-0.7	-0.9
LDL Cholesterol	0.6	0.9	3.9	-0.5	-0.6	0.9	-0.5	-0.6	-2.0	0.6
Lupus	1.5	2.3	4.4	-1.5	-1.3	-0.6	-2.1	0.2	-2.0	1.7
Neuroticism (2016)	1.4	2.1	5.1	-2.3	1.0	0.6	-1.0	-2.1	0.0	1.6
Primary Biliary Cirrhosis	0.7	0.9	3.6	-0.0	-0.3	-1.9	0.1	0.2	0.2	-1.6
Rheumatoid Arthritis	0.7	1.0	2.5	1.2	-0.0	-0.9	1.6	0.8	0.1	-1.4
Schizophrenia (2014)	0.2	0.5	0.9	0.2	0.6	-0.8	-0.2	-0.8	-0.9	0.9
Triglycerides	1.6	2.6	5.4	-1.7	-1.2	-0.7	-2.3	-1.3	-1.8	1.6
Type 2 Diabetes (T2D) (2012)	1.4	1.7	5.9	-0.8	-2.4	-0.6	-0.5	0.9	-0.7	1.8
Ulcerative Colitis	1.3	1.9	5.1	1.0	2.1	-1.0	2.3	-0.2	0.6	-1.1
Blood Eosinophil Count	2.9	22.2	88.5	-0.7	-2.1	-2.6	-9.4	1.2	-5.1	5.2
Blood Platelet Count	0.2	2.7	6.6	1.4	-2.0	-0.4	2.6	-0.1	-1.0	-2.3
Blood Red Count	0.7	6.6	17.4	-1.9	1.6	1.1	-4.2	-1.4	-1.5	4.2
Blood White Count	0.9	6.8	18.1	-1.2	0.1	4.2	-2.8	-3.0	-1.3	3.1
Heel T-Score	0.7	5.3	13.9	-2.1	1.0	3.0	-2.5	-3.7	-0.6	1.5
BMI	3.2	18.3	35.0	5.9	-5.4	2.9	5.2	3.8	1.3	-3.4
Height	2.4	45.6	153.8	-4.5	3.3	-2.9	-12.4	-1.1	-7.5	8.3
Waist Hip Ratio (WHR)	1.8	8.0	20.4	-1.5	2.8	-1.8	-4.5	-2.2	-0.9	4.1
Systolic Blood Pressure	1.5	7.5	16.9	-1.7	0.8	1.3	-3.9	-0.0	-3.9	4.1
Smoking Status	1.1	2.7	17.3	0.6	-4.2	0.9	-0.0	0.2	-0.7	0.2
Allergy or Eczema	0.8	2.1	7.8	-0.5	1.8	-0.1	-2.8	1.3	-0.9	1.0
Cardiovascular Disease	0.4	1.4	3.6	-1.1	-0.1	1.9	-0.5	0.0	-1.2	1.8
Hypothyroidism (self reported)	0.7	1.6	5.5	-0.1	1.3	2.4	0.5	-0.4	0.8	1.7
Respiratory disease	1.4	3.0	6.7	1.6	-1.4	-0.3	-2.6	2.0	-0.6	2.3
Type 2 Diabetes (T2D) (2018)	0.7	1.2	4.5	-0.5	-2.1	0.1	-0.8	-1.4	-0.7	0.9
Lung FEV1/FVC ratio	0.5	2.6	7.7	0.1	-2.0	-2.8	-1.8	-1.5	-0.8	0.3
Lung FVC	2.2	11.2	25.6	3.5	-2.1	-1.7	5.1	3.3	3.2	-3.6
Neuroticism	1.3	3.2	11.9	-0.6	1.2	1.8	-0.7	-1.9	-0.9	3.5
Chronotype (morning person)	4.2	9.7	27.6	3.6	0.2	-0.9	4.4	2.5	0.7	-5.2
Hair Pigment	0.0	1.1	6.7	0.6	-0.7	-0.0	0.4	2.6	-0.1	-0.5
Tanning	0.1	1.6	6.0	-0.9	-0.8	2.4	-1.0	-0.9	-0.9	1.1
Hand grip strength (left)	0.4	1.0	3.4	-0.5	-1.8	0.4	-0.9	-0.4	-1.4	0.2
Number of treatments/medications taken	1.5	2.8	7.0	1.9	-0.3	2.2	-0.8	1.8	0.2	2.6
Average weekly spirits intake	0.6	0.7	1.3	0.2	0.9	0.8	-1.1	1.2	-0.3	0.9
Sensitivity / hurt feelings	1.0	1.8	4.2	-0.8	1.1	-0.4	-1.2	-2.0	-1.2	1.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.3	0.9	1.5	0.2	-1.4	-1.3	-0.1	1.8
Hearing difficulty/problems: Yes	0.3	0.4	2.0	1.4	0.3	-0.5	0.7	0.3	-0.2	0.2
Relative age of first facial hair	5.4	11.0	32.7	-2.6	-1.3	-0.3	-5.7	-1.7	-3.6	4.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.9	0.7	0.7	-0.5	1.0	0.8	0.6	0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.6	0.2	-1.9	0.4	-1.3	0.4	0.1	0.9
Ever had hysterectomy (womb removed)	1.3	1.5	4.2	-1.2	-2.1	1.6	-1.0	-1.0	0.4	0.4
Systolic blood pressure, automated reading	0.7	1.9	7.3	0.1	0.0	1.7	-1.0	0.3	-2.7	1.4
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.4	1.2	0.5	-1.6	0.9	-0.2	2.1	-1.1
Angina	0.5	0.7	2.3	0.2	0.3	1.0	1.5	-0.3	1.0	-0.5
Medication for hormone replacement therapy	1.5	1.7	4.6	-0.9	-0.5	1.0	-2.1	-0.6	-0.7	2.1
Vitamin and mineral supplements	0.8	1.1	3.1	-0.2	-0.6	1.0	1.8	-0.9	0.9	-1.3
Supplements: Zinc	0.7	0.7	2.3	1.2	0.4	0.1	0.8	1.5	0.5	0.6
Medication: Co-codamol	1.4	1.6	7.6	0.1	-1.3	2.8	0.7	-0.9	0.6	0.7
Medication: Metformin	0.3	0.4	2.2	0.2	-1.5	-0.5	-0.0	-0.2	-0.7	0.2
Diabetes (father)	1.1	1.4	2.9	-0.8	-1.7	-1.4	-0.9	-1.6	0.3	0.8
Diabetes (mother)	1.3	1.7	3.7	-1.2	1.1	0.4	-1.9	-1.2	-1.4	1.5
Severe depression (siblings)	1.3	1.4	5.4	0.4	1.3	-0.4	-0.7	1.3	-0.5	2.3
Pack years adult smoking proportion	1.2	1.9	4.7	1.7	-0.4	2.2	1.9	1.1	0.5	0.4
Impedance of leg (right)	8.3	40.1	83.2	-8.3	5.9	-0.8	-9.1	-6.3	-3.9	6.2
Leg fat-free mass (left)	1.2	6.2	12.6	3.6	-3.4	2.4	1.6	3.2	0.5	-0.6
Trunk fat percentage	0.5	2.2	13.1	0.2	-0.6	3.6	-1.1	-0.2	-0.4	0.6
Hand grip strength (right)	0.8	2.1	4.8	-1.0	-2.0	1.0	-1.7	-0.1	-2.2	0.9
Townsend deprivation index at recruitment	1.9	2.6	7.7	-0.9	-0.1	2.8	-0.6	-1.7	-1.6	2.0
Current tobacco smoking	0.2	0.4	0.9	0.7	-1.0	0.9	0.2	-0.2	-0.4	-0.2
Average weekly fortified wine intake	0.7	0.8	2.2	-0.0	1.5	1.3	-0.4	0.9	0.0	0.9
Maternal smoking around birth	1.7	2.4	9.9	2.1	-3.1	-0.8	1.2	0.6	-0.5	-0.1
Fed-up feelings	1.8	3.3	10.7	-0.4	-0.2	3.3	-0.7	-2.4	-0.9	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	6.4	-1.2	1.0	0.8	-2.2	-2.5	-1.2	2.5
Relative age voice broke	4.3	6.5	16.3	-2.4	-1.6	-1.3	-4.0	-1.7	-3.2	2.5
Taking other prescription medications	3.3	5.2	18.4	0.6	-0.2	2.2	-3.1	-0.1	-1.6	4.3
Age when periods started (menarche)	6.2	14.8	34.2	-3.5	-3.0	0.5	-5.8	-3.3	-4.1	4.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.3	-0.9	0.4	-0.5	0.0	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.6	0.3	1.9	1.6	-1.5	1.2	-0.7	1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.3	0.4	-0.4	0.1	-0.5	1.2	-0.4	-0.5
Qualifications: CSEs or equivalent	2.5	3.3	5.8	-2.2	-0.9	1.8	-2.4	-1.8	-1.6	1.6
Serious illness, injury or assault to yourself	0.8	0.9	2.1	1.2	0.3	0.8	0.9	1.5	1.1	0.1
High blood pressure	0.5	1.3	5.7	0.5	-0.5	1.0	-0.4	2.4	-0.2	1.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	7.6	-0.5	2.4	-0.2	-2.8	1.0	-0.2	0.8
Multivitamins +/- minerals	1.1	1.4	3.9	-0.1	0.1	-0.8	-2.0	1.1	-1.6	1.2
Stomach or abdominal pain in last month	4.0	4.9	10.4	-2.4	1.1	2.7	-1.5	-2.8	-0.1	3.2
Supplements: Glucosamine	0.3	0.4	1.3	-0.4	-0.2	0.3	-0.9	1.1	-0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.1	0.7	0.9	-0.2	-1.0	0.9	0.4
Medication: Atenolol	1.0	1.3	3.2	-0.5	-1.0	1.2	-0.8	1.4	0.5	1.8
Medication: Levothyroxine sodium	0.4	0.6	1.5	0.8	0.1	0.4	0.9	0.8	1.2	0.8
Sitting height	0.6	3.9	17.0	-0.9	-0.6	0.1	-4.1	0.3	-1.9	2.3
Chronic bronchitis/emphysema (father)	1.3	1.6	3.8	-0.2	-1.1	0.7	-1.1	-1.4	-1.9	1.6
High blood pressure (mother)	0.8	1.1	3.9	0.0	2.0	1.3	0.0	1.0	-0.5	1.0
Body mass index (BMI)	3.1	13.1	20.2	4.4	-4.5	4.1	4.5	3.0	1.5	-2.0
Impedance of leg (left)	7.5	36.7	72.6	-7.9	6.1	-1.0	-8.5	-5.9	-3.9	5.8
Leg predicted mass (left)	1.2	6.1	12.0	3.5	-3.5	2.3	1.5	3.2	0.5	-0.6
Trunk fat mass	0.6	2.6	12.8	1.0	-1.5	3.6	-0.9	0.7	-0.6	0.9
Waist circumference	0.5	1.9	4.5	1.8	-2.1	2.1	0.9	0.7	0.2	0.2
Number of incorrect matches in round	2.5	4.1	8.1	2.1	1.2	2.0	2.3	2.9	1.8	-1.5
Past tobacco smoking	2.1	3.8	18.2	0.1	4.3	0.5	1.2	0.0	1.9	-1.7
Alcohol usually taken with meals	0.5	0.8	2.8	-0.1	0.8	-1.4	-0.4	1.7	0.1	-0.5
Nervous feelings	0.9	1.7	4.9	0.2	2.2	-1.5	-1.4	0.8	-0.6	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	6.4	0.4	0.9	2.2	-1.4	-2.0	-0.0	2.5
Hearing difficulty/problems with background noise	0.7	1.1	2.6	-1.4	-0.8	-1.1	0.5	-1.6	-0.8	-0.7
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	0.7	0.4	0.5	-0.7	-0.2	1.0	1.3
Had menopause	2.8	3.4	7.3	2.7	-0.5	-1.0	2.5	1.9	1.8	-1.6
Had other major operations	0.4	0.5	1.7	0.0	-0.3	1.3	0.0	0.1	0.5	1.3
Forced vital capacity (FVC)	0.3	1.3	3.7	0.4	-0.3	-1.9	-0.3	1.9	0.7	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.6	-0.3	1.6	0.9	-1.2	1.0	0.1	0.4
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	8.2	-0.8	0.3	0.5	-1.8	-2.9	-1.3	2.4
Qualifications: None of the above	2.1	4.6	15.8	-0.8	-4.0	1.7	-1.5	-0.5	-2.5	2.0
Financial difficulties in last 2 years	1.8	2.4	7.2	-2.1	0.7	1.1	-1.6	-2.7	-0.5	0.8
Mouth/teeth dental problems	2.4	3.6	10.7	-0.2	1.1	-2.0	1.9	-0.4	2.4	-3.3
Heart attack	1.0	1.3	7.0	0.3	-0.2	2.7	1.1	-0.1	-0.4	0.4
Allergy	1.4	3.1	8.9	-1.1	-1.0	0.6	3.0	-2.9	0.5	-1.2
Pain all over the body in last month	0.9	0.9	4.2	0.4	-2.0	0.3	0.4	-1.1	0.7	0.6
Diabetes (self-reported)	0.2	0.3	0.9	0.6	-0.9	-0.3	0.2	-0.6	0.1	0.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	5.7	-0.9	0.5	-1.1	-2.4	0.6	-1.3	0.7
Medication: Ramipril	0.9	1.1	2.6	1.6	-1.1	0.6	1.1	1.5	0.2	0.6
Medication: Simvastatin	0.3	0.5	1.0	0.7	-0.9	0.9	1.0	0.2	0.2	-0.2
Fluid intelligence score	0.7	1.5	6.6	0.3	0.7	-2.6	0.8	0.1	-0.3	-1.6
Illnesses of siblings	1.6	2.3	7.9	-0.4	-1.5	-2.3	0.6	-0.1	0.4	-2.8
Neuroticism score	1.5	3.1	8.8	-0.0	1.9	1.7	-1.1	-2.0	-1.2	3.0
Weight	0.9	4.6	10.2	2.6	-3.2	3.0	0.4	2.3	-0.6	0.6
Impedance of arm (right)	4.6	21.5	42.2	-6.0	6.2	-2.6	-6.5	-4.7	-1.4	1.9
Arm fat percentage (right)	1.0	4.1	11.6	2.1	-1.8	3.4	2.1	1.1	1.4	-1.4
Trunk fat-free mass	0.7	4.2	9.4	2.4	-3.1	1.6	0.1	2.8	-1.2	1.6
Hip circumference	0.9	3.7	8.6	1.8	-2.9	2.7	1.9	1.4	0.4	-1.1
Time employed in main current job	4.1	4.8	14.1	2.1	0.6	-0.1	3.8	0.3	2.1	-3.2
Alcohol intake versus 10 years previously	1.2	1.9	6.2	-0.4	-0.8	1.2	-2.5	-1.1	-1.0	1.5
Father’s age at death	0.4	0.6	2.9	0.0	-0.5	-1.7	0.4	-0.8	-0.1	-0.3
Worrier / anxious feelings	1.5	2.9	14.3	0.7	3.8	2.1	0.2	-0.2	0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	10.2	-2.4	1.6	1.9	-1.7	-1.9	-1.2	3.2
Falls in the last year	0.8	1.1	2.0	1.0	-1.4	-0.5	1.4	1.1	1.2	-0.4
Hair/balding pattern: Pattern 3	0.7	1.0	4.1	-2.0	0.0	-0.9	-0.0	0.0	-0.8	-1.2
Number of live births	1.2	1.7	7.6	1.3	-2.8	0.9	-0.1	0.2	-1.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	5.2	0.1	-0.6	-2.3	-0.7	1.0	1.1	1.2
Pulse rate	0.7	1.2	3.7	-0.8	1.4	-0.1	-0.7	-1.9	1.1	0.2
Happiness	1.1	1.4	4.7	-0.2	2.2	0.8	-0.7	-1.0	-0.9	1.3
Noisy workplace	0.3	0.4	1.0	0.9	-0.4	0.5	0.1	-0.6	0.0	1.0
Qualifications: A levels/AS levels or equivalent	1.7	3.7	7.6	2.1	2.8	-2.2	1.7	0.8	1.8	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.6	-0.1	-0.0	1.3	0.9	0.5	-0.4	-0.4
Mouth/teeth dental problems: Dentures	1.6	2.7	5.7	2.4	-1.3	2.1	-0.3	2.0	-1.6	0.5
Asthma	1.5	2.9	6.7	1.9	-0.1	0.4	-2.3	2.6	-0.3	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.3	0.9	0.1	1.5	-0.2	1.3	0.2	1.3
Medication: Cholesterol lowering	0.4	0.6	2.0	0.3	-0.8	1.4	0.7	0.7	-0.3	-0.1
Depression (self-reported)	1.1	1.3	2.2	1.5	1.4	1.2	0.5	0.6	1.0	1.2
Medication: Lansoprazole	1.0	1.2	5.9	-0.0	0.3	2.4	0.3	-0.6	0.9	1.0
Prospective memory result	1.2	1.5	5.4	1.6	0.8	2.3	-0.1	0.8	0.9	0.6
Lung cancer (father)	1.0	1.2	5.2	0.1	-1.7	0.4	-0.2	-2.3	0.5	0.0
Illnesses of mother	1.8	2.2	7.1	0.3	-0.9	-1.4	1.4	0.0	1.9	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	6.3	0.6	-1.0	-2.5	-0.4	1.4	0.8	0.6
Pulse wave Arterial Stiffness index	0.9	1.0	3.7	-1.0	-0.5	0.5	-1.2	0.0	-0.6	1.9
Impedance of arm (left)	4.3	19.8	39.8	-6.0	5.4	-2.8	-6.3	-4.7	-1.5	1.4
Arm fat mass (right)	1.3	5.4	15.2	2.6	-2.7	3.9	1.9	1.9	0.8	-0.6
Trunk predicted mass	0.7	4.1	8.4	2.4	-2.9	1.7	0.1	2.8	-1.2	1.6
Standing height	2.0	19.4	69.1	-3.3	1.6	-2.2	-8.3	-0.8	-4.5	5.3
Length of working week for main job	2.1	2.4	7.8	0.2	0.3	2.7	2.8	0.5	0.9	-0.4
Exposure to tobacco smoke at home	0.4	0.5	1.8	0.9	-1.4	0.4	0.1	-0.2	-0.7	0.4
Breastfed as a baby	1.9	2.4	7.3	0.3	-2.7	-2.1	0.3	1.3	0.4	-1.7
Tense / ‘highly strung’	2.0	3.3	9.8	-0.9	2.0	2.2	-1.4	-1.3	-0.4	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	7.4	1.3	1.2	1.8	-1.0	-0.6	-0.4	2.7
Hair/balding pattern: Pattern 4	0.4	1.0	3.7	-0.3	-1.3	0.9	-0.6	0.7	-1.9	0.5
Birth weight of first child	3.4	6.2	13.2	3.6	-1.6	-2.6	2.4	2.3	0.7	-3.0
Peak expiratory flow (PEF)	0.4	1.0	3.4	0.2	-1.8	-1.4	-0.6	0.4	-0.4	0.7
Pulse wave reflection index	1.0	1.2	3.2	1.2	-1.8	0.0	1.0	1.6	-0.5	0.0
Ever highly irritable/argumentative for 2 days	4.6	5.5	10.4	-1.6	-0.3	2.2	-2.8	-2.1	-2.9	3.2
Loud music exposure frequency	0.3	0.3	1.0	-0.0	0.4	-0.6	0.1	-1.0	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.1	1.4	2.0	-0.9	0.3	-0.1	1.4	-0.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	4.5	-1.9	0.1	-1.0	-1.4	-1.9	-2.1	1.6
Blood clot in the leg (DVT)	0.6	0.8	2.3	0.8	-1.5	-1.1	0.6	-0.3	1.0	-0.4
Medication: Paracetamol	1.8	3.0	7.2	2.7	-1.5	-0.1	1.8	2.2	1.5	-0.9
Headache pain in last month	0.2	0.3	1.1	0.4	0.3	0.9	0.2	-0.1	-0.0	1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.9	-0.9	1.0	-2.2	-0.5	-0.7	0.1	-0.6
Glaucoma (self-reported)	1.4	1.6	6.0	-1.3	2.4	0.6	-0.3	-1.7	-0.6	0.5
Gout (self-reported)	0.7	1.0	2.1	0.0	0.8	1.4	-0.7	-1.2	-0.6	1.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.6	1.0	0.9	1.6	1.5	0.9	1.6	0.8
Medication: Amlodipine	0.3	0.5	0.9	0.7	-0.1	1.0	0.0	0.8	-0.8	0.8
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.6	0.9	-0.7	0.5	-2.4	0.8	-1.3	2.2
Birth weight	0.7	1.4	3.1	1.6	-1.8	-1.1	0.8	1.2	0.3	-1.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.3	0.4	-1.0	1.3	-0.8	0.4	-0.4	1.8
High blood pressure (siblings)	1.1	1.6	7.2	0.3	0.0	0.8	-1.2	0.8	-1.1	2.7
Forced vital capacity (FVC), Best measure	0.5	1.8	5.4	1.0	-0.5	-2.3	-0.3	2.3	0.3	0.6
Body fat percentage	0.6	2.5	15.4	0.4	-1.1	3.9	-0.5	-0.2	-0.2	0.5
Leg fat percentage (right)	0.9	3.3	18.4	0.2	-1.6	4.3	-0.2	-0.2	-0.4	1.2
Arm fat-free mass (right)	1.1	5.4	12.1	2.5	-3.5	2.9	0.4	2.8	-0.9	1.5
Exposure to tobacco smoke outside home	1.6	2.1	5.2	1.8	-1.9	2.3	1.3	0.7	-0.6	0.3
Comparative body size at age 10	4.1	11.4	20.6	4.1	-4.5	-2.0	3.9	3.1	0.6	-3.6
Number of full brothers	0.5	0.6	1.9	1.1	-1.4	0.2	0.9	0.4	0.3	-0.2
Worry too long after embarrassment	0.8	1.3	3.5	-0.4	1.1	-1.7	1.0	-1.9	-0.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.4	1.2	1.6	1.3	-0.1	-0.7	0.8	1.4
Wheeze or whistling in the chest in last year	2.2	3.8	8.5	0.7	0.6	2.9	-2.5	1.4	-1.1	2.9
Number of children fathered	0.6	0.6	1.2	-0.0	-0.9	1.1	-1.1	-0.5	-0.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.0	1.4	1.3	0.7	0.8	1.4	1.0	-0.3
Age at first live birth	5.5	9.7	32.1	1.3	0.0	-5.7	1.9	2.2	1.8	-4.8
Pulse wave peak to peak time	0.6	0.7	2.8	0.6	0.8	-0.4	0.7	-0.2	0.4	-1.7
Health satisfaction	2.5	3.3	11.4	-0.2	1.6	2.0	-2.0	0.0	-0.9	3.4
Shortness of breath walking on level ground	0.9	1.1	3.2	-0.1	0.3	1.8	-1.2	-0.3	0.6	1.5
Qualifications: College or University degree	3.3	10.3	26.1	2.2	5.1	-2.5	3.8	1.1	3.5	-2.6
Eye problems/disorders: None of the above	0.7	0.8	2.2	-0.9	-1.5	0.8	0.4	0.1	-0.9	-1.1
Mouth/teeth dental problems: Loose teeth	2.7	3.2	7.5	-1.1	-1.4	2.2	-1.3	-1.3	-1.8	2.7
Emphysema/chronic bronchitis	1.2	1.4	3.3	1.1	-1.5	-0.7	0.4	1.8	-0.9	1.1
Medication for pain relief, constipation, heartburn	2.0	3.4	9.5	-3.1	0.6	-1.3	-1.7	-2.8	-0.8	-0.9
Neck or shoulder pain in last month	2.4	3.4	7.2	-1.5	-2.2	-0.2	-1.7	-1.8	-2.7	1.7
Medication: Blood pressure	1.1	2.0	4.2	2.0	-0.7	2.1	0.5	1.8	0.3	1.3
Angina (self-reported)	0.9	1.2	3.8	0.1	0.6	1.6	2.0	-0.4	1.1	-0.6
Migraine (self-reported)	0.8	1.0	3.2	-0.4	-0.8	0.4	-0.6	-1.2	-0.9	1.8
Medication: Ibuprofen	0.8	0.9	2.8	0.3	0.4	1.7	-0.2	0.6	-0.6	1.6
Medication: Allopurinol	0.2	0.3	1.3	0.6	1.2	0.1	0.3	-0.0	0.2	0.3
Medication: Omeprazole	0.7	0.9	3.0	0.4	-0.9	1.1	-0.3	0.5	0.7	1.7
Medication: Seretide 50 evohaler	1.0	1.1	3.0	1.7	-0.9	0.3	-0.6	1.7	0.7	0.6
Mean time to correctly identify matches	1.4	2.7	7.6	1.2	-0.0	-0.6	2.8	1.1	2.3	-1.6
Heart disease (mother)	0.4	0.5	1.6	0.6	0.8	0.4	0.1	1.3	-0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.2	0.6	-0.5	-0.6	-0.6	-1.2	0.7
Whole body fat mass	0.8	3.4	15.4	1.4	-2.2	3.9	-0.1	1.0	-0.3	0.6
Leg fat mass (right)	1.1	4.1	17.8	1.5	-2.6	4.2	0.4	1.1	-0.2	0.8
Arm predicted mass (right)	1.0	5.3	11.6	2.7	-3.4	2.8	0.6	2.8	-0.8	1.3
Pulse rate, automated reading	1.1	3.5	8.0	-1.4	2.1	2.2	-1.9	-2.8	0.1	1.1
Alcohol intake frequency.	0.7	1.7	5.0	0.4	-1.1	1.4	-1.6	0.0	-0.9	2.2
Comparative height size at age 10	0.2	1.1	3.3	-0.3	1.1	-1.2	-1.8	1.1	-0.9	0.2
Number of full sisters	3.6	4.4	10.0	-1.7	-0.3	2.0	-1.1	-3.2	-1.7	3.0
Suffer from ‘nerves’	1.4	2.2	4.6	2.1	2.1	0.1	1.4	1.9	0.9	-0.0
Overall health rating	3.4	7.4	21.5	-0.5	0.1	4.1	-2.7	-1.6	-1.8	4.6
Chest pain or discomfort	1.0	1.4	4.1	-1.2	0.2	2.0	-1.3	0.5	-0.8	1.3
Had major operations	1.1	1.3	3.7	0.8	-1.6	-1.9	-0.3	1.0	-0.9	0.3
Age at last live birth	4.8	7.0	19.5	1.1	-0.3	-4.4	2.1	1.8	1.0	-4.4
Family relationship satisfaction	3.9	4.8	8.1	-2.4	1.7	2.2	-2.4	-2.3	-1.0	2.8
Leg pain on walking	4.3	5.3	14.0	-1.6	0.1	3.1	-2.8	-1.4	-1.3	3.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	-0.4	0.5	1.4	-0.7	-0.8	0.2	1.0
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.8	-0.8	-0.9	0.6	-1.2	-0.3	-2.4	1.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	0.4	-0.2	-0.0	0.0	-0.5	0.0	0.9
Medication: Aspirin	0.4	0.5	1.9	0.8	-0.2	0.8	0.6	1.4	-0.5	0.2
Supplements: Vitamin C	0.3	0.3	1.0	-0.8	-0.0	-0.1	-1.0	-0.7	-0.3	0.3
Knee pain experienced in last month	1.5	2.3	6.5	-0.4	-0.6	2.5	-1.3	0.2	-1.1	2.5
Hypertension (Self-reported)	0.6	1.7	8.3	1.1	-0.1	0.8	0.2	2.9	-0.1	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	4.1	-1.6	-1.1	1.3	-1.4	-0.3	-0.8	2.0
Illnesses of father: Heart disease	0.4	0.5	1.1	-0.4	0.7	0.8	0.0	0.6	-1.0	1.0
Illnesses of siblings: Diabetes	1.6	1.9	4.5	-0.8	-0.8	0.2	-2.1	-1.7	-0.7	2.0
Smoking status: Previous	3.0	4.5	20.8	-0.4	-4.6	-0.5	-1.3	0.8	-2.3	1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	12.9	-0.7	1.2	0.4	-3.6	0.6	-1.9	3.6
Whole body fat-free mass	0.9	5.2	10.2	3.1	-3.2	2.2	0.8	3.2	-0.6	0.9
Leg fat-free mass (right)	1.3	6.7	15.0	3.9	-3.2	2.0	2.0	3.5	0.7	-1.0
Arm fat percentage (left)	1.1	4.3	12.3	2.0	-2.1	3.5	2.0	1.0	1.3	-1.6
Average weekly red wine intake	1.4	2.0	5.0	2.2	0.3	-0.9	1.1	2.1	-0.1	-1.6
Handedness (chirality/laterality): Left-handed	1.8	2.1	5.3	0.7	-0.3	-2.3	1.9	0.8	0.4	-2.2
Mood swings	1.9	3.5	10.1	0.6	2.0	3.2	-0.6	-1.9	-0.3	2.5
Loneliness, isolation	1.2	1.7	5.0	-0.2	0.8	1.8	-1.2	0.3	-1.1	2.2
Long-standing illness, disability or infirmity	0.7	1.0	3.2	1.5	-0.7	0.9	0.3	0.5	0.2	1.8
Ever had bowel cancer screening	0.7	0.8	2.2	-1.2	1.5	0.1	-0.4	0.3	-1.0	1.0
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.6	-0.8	-0.2	0.1	-0.3	0.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	-0.0	-0.6	-0.2	0.3	-1.1	-0.5	-0.3
Friendships satisfaction	2.3	2.9	6.0	-2.1	2.3	0.2	-1.8	-2.4	-0.3	1.1
Qualifications: nursing, teaching	2.2	3.4	5.5	1.7	1.9	-1.2	2.2	0.9	2.4	-2.1
Commuting to job workplace: Walk	1.6	1.7	3.5	0.9	0.8	-0.2	1.8	1.0	1.9	-1.7
Eye problems/disorders: Cataract	0.9	1.1	4.0	1.0	-0.6	-2.0	0.7	0.4	1.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.3	-0.8	-0.3	0.3	-1.8	-0.6	-0.7	1.6
Medication for cholesterol	1.1	1.7	7.0	0.4	1.1	-0.8	1.5	-0.7	0.2	-2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.4	-0.3	1.8	1.9	-1.2	-0.1	-0.6	2.3
Back pain experienced in last month	3.7	5.3	10.7	-2.1	1.4	3.3	-2.0	-2.1	-1.2	3.2
Mineral and other dietary supplements	0.4	0.6	2.0	1.4	-0.0	-0.7	0.6	0.1	0.8	-0.8
Breast cancer (self-reported)	0.7	0.8	3.7	-0.7	-1.9	-0.4	-0.4	-1.0	-0.3	0.2
Asthma (self-reported)	1.5	3.0	7.1	2.0	-0.2	0.3	-2.3	2.7	-0.1	2.0
Osteoporosis (self-reported)	0.3	0.4	1.1	0.7	-0.3	0.6	0.6	0.1	1.1	0.0
Osteoarthritis (self-reported)	1.3	1.7	4.5	1.3	-0.4	2.0	0.5	2.1	0.9	0.5
Medication: Aspirin	0.5	0.7	2.4	0.8	-0.4	0.6	0.5	1.6	-0.8	0.6
Medication: Gliclazide	0.6	0.7	2.4	-1.3	0.1	0.5	-0.4	-1.6	-0.0	0.7
Illnesses of father: None of the above (group 1)	0.8	1.0	2.9	0.3	-0.6	0.7	1.3	-1.3	1.7	-0.0
Smoking status: Current	0.2	0.3	0.9	1.0	-0.6	0.7	0.3	-0.4	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	8.0	2.1	-0.7	-1.8	2.8	2.0	2.2	-2.0
Whole body water mass	0.9	5.4	10.7	3.2	-3.2	2.3	1.0	3.3	-0.4	0.8
Leg predicted mass (right)	1.3	6.9	15.3	3.9	-3.3	2.0	2.1	3.5	0.7	-1.0
Arm fat mass (left)	1.3	5.5	13.5	2.6	-3.0	3.7	1.9	2.0	0.8	-0.9
Number of self-reported non-cancer illnesses	1.1	1.9	8.1	0.5	-0.4	0.7	-1.5	1.5	-0.3	2.8
Average weekly champagne plus white wine intake	0.4	0.6	1.3	-1.0	1.1	-0.6	-0.3	-0.7	0.7	-0.4
Miserableness	1.5	2.6	7.4	0.3	-0.4	2.6	-0.3	-1.8	-0.0	2.7
Guilty feelings	0.6	0.8	2.2	0.3	-0.3	1.3	-0.2	0.2	-1.2	1.5
Wears glasses or contact lenses	0.5	0.6	1.2	-0.3	-1.1	-0.2	-1.0	-1.1	-0.8	0.4
Ever taken oral contraceptive pill	1.3	1.5	3.1	-1.8	0.1	1.4	-1.3	-1.4	-0.5	1.1
Hearing aid user	0.9	1.0	3.1	0.7	0.7	1.8	0.1	-1.1	-0.2	1.3
Mother’s age at death	1.3	1.7	4.8	1.2	0.6	-2.2	0.5	2.0	0.7	-0.3
Financial situation satisfaction	1.4	1.8	4.1	-1.2	0.0	0.8	-2.0	-1.2	-1.4	1.7
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.4	1.2	0.7	-0.1	0.2	0.6	1.2	0.3
Commuting to job workplace: Public transport	3.6	4.3	10.6	1.3	-0.2	-1.3	2.7	0.2	2.9	-3.2
Eye problems/disorders: Glaucoma	2.2	2.6	13.3	0.1	3.6	1.6	-0.1	-1.1	0.1	0.9
Medication: Blood pressure	0.9	1.7	5.6	0.3	0.3	0.8	-0.7	2.2	-0.5	2.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.4	-0.4	-0.1	2.2	-1.3	-0.1	-1.4	2.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.6	-0.8	0.7	1.3	-0.6	0.1	-0.6	0.9
High cholesterol (Self-reported)	0.6	1.1	3.5	0.0	-0.9	1.4	1.9	0.7	-0.2	-1.0
Medication: Bendroflumethiazide	0.6	1.0	3.2	-0.3	0.1	1.8	0.1	0.6	0.1	1.7
Medication: Paracetamol	1.1	1.8	5.5	2.3	-0.6	0.7	1.3	1.6	1.2	-0.1
Medication: Lisinopril	0.9	1.2	3.8	1.1	-0.2	0.7	-0.8	2.0	1.1	0.9
Medication: Atorvastatin	1.2	1.5	3.1	1.0	-1.8	-1.7	1.3	0.8	0.3	-0.9
Illnesses of father: High blood pressure	1.0	1.2	3.5	-0.3	0.7	-1.0	-1.9	0.6	-1.0	1.4
Alcohol drinker status: Never	0.5	0.6	2.4	1.6	-0.2	-0.1	0.7	0.9	0.6	0.4
Ever smoked	1.2	2.0	6.0	-0.3	-2.4	0.2	-1.3	-0.4	-1.3	2.2
Basal metabolic rate	0.9	5.1	9.9	2.9	-3.1	2.6	0.7	3.0	-0.4	0.9
Leg fat percentage (left)	0.8	2.9	16.7	0.8	-1.6	4.1	0.4	0.2	-0.3	0.6
Arm fat-free mass (left)	1.1	5.4	9.6	2.8	-3.1	3.0	0.6	2.8	-0.7	1.6
Number of operations (self-reported)	0.7	1.0	3.0	0.2	-1.6	1.2	-0.6	0.1	0.3	1.7
Average weekly beer plus cider intake	1.4	2.0	8.9	-0.4	-3.0	0.8	-0.8	-1.5	-0.8	0.9
Irritability	1.2	1.9	4.8	0.5	1.5	1.2	-0.1	-2.1	-0.6	2.2
Risk taking	2.2	3.2	5.3	-1.4	0.2	1.5	-2.1	-2.3	-1.8	2.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.7	0.9	0.5	-0.1	-0.6	1.6	-0.4	0.9
Fractured/broken bones in last 5 years	0.5	0.6	1.3	0.1	-0.0	-1.1	0.8	1.0	0.5	-1.1
Age started oral contraceptive pill	1.4	1.8	3.2	0.7	-0.5	-1.8	1.7	0.7	1.4	-1.8
Diastolic blood pressure, automated reading	1.2	3.7	10.8	0.1	0.3	3.3	-1.7	0.4	-1.2	3.2
Ever depressed for a whole week	3.0	3.6	8.2	-1.3	0.2	0.8	-2.5	-2.2	-1.9	2.9
Unable to work because of sickness or disability	0.9	1.2	3.3	1.1	-0.8	-0.4	1.5	-1.0	1.8	-0.2
Commuting to job workplace: Cycle	2.6	3.1	6.1	2.5	-0.7	-2.2	1.6	0.8	1.5	-2.3
Myopia	0.4	0.6	2.1	-0.5	-0.7	-0.5	0.1	0.2	0.8	-1.5
Vascular/heart problems diagnosed by doctor	0.5	1.2	4.7	-0.8	0.5	-1.2	-0.0	-2.2	0.3	-1.2
Cholesterol lowering medication	0.5	0.8	2.8	0.8	-1.7	0.5	1.3	-0.3	0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.9	0.7	-0.4	1.7	0.4	0.2	1.3	1.5
Pain experienced in last month	3.0	5.0	14.1	0.9	1.1	-2.9	1.8	1.4	2.2	-3.8
Supplements: Calcium	0.6	0.6	2.7	-1.6	0.7	0.7	-0.7	-0.0	0.3	0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	0.0	-0.4	-0.4	-0.2	0.6	-0.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	6.3	0.3	-0.2	2.5	1.1	-0.0	-0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.1	1.2	-1.4	-1.3	0.8	0.1	1.1	-0.7
Heart disease (siblings)	0.8	1.0	3.4	-0.3	1.3	1.8	0.3	-1.3	0.3	0.6
Alcohol drinker status: Previous	2.5	2.8	7.2	1.5	-1.7	0.3	2.7	0.2	1.8	-2.0
Pack years of smoking	1.4	2.0	4.4	2.1	-0.7	1.4	2.1	1.7	0.2	0.3
Impedance of whole body	6.5	32.9	70.2	-7.6	6.3	-2.2	-8.4	-5.8	-3.0	3.8
Leg fat mass (left)	1.1	4.4	16.7	2.0	-2.7	4.1	0.8	1.5	-0.2	0.5
Arm predicted mass (left)	1.1	5.4	10.0	3.0	-3.2	3.0	0.6	2.7	-0.7	1.4