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chr19:9,498,315-12,692,001

Best TWAS P=8.32e-36 · Best GWAS P=1.96e-30 conditioned to 0.094

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
43	The Cancer Genome Atlas	Rectum Adenocarcinoma	MRPL4	0.24	0.14	blup	40	0.10	2.5e-03	-10.45	-12.5	8.3e-36	-0.34	0.02	0.07	TRUE
28	YFS	Blood	CDKN2D	0.16	0.08	lasso	10	0.11	3.5e-35	6.82	-9.3	1.3e-20	0.00	1.00	0.00	TRUE
44	The Cancer Genome Atlas	Thyroid Carcinoma	CDKN2D	0.07	0.01	enet	6	0.02	3.4e-03	-0.77	-7.6	3.4e-14	-0.04	0.01	0.03	TRUE
24	GTEx	Whole Blood	C19orf66	0.08	0.02	lasso	4	0.07	5.9e-07	3.76	6.8	9.7e-12	0.55	0.14	0.23	TRUE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF440	0.05	0.02	lasso	2	0.02	1.3e-05	-6.80	-6.8	1.1e-11	-0.04	0.01	0.99	TRUE
26	ROSMAP	Brain Pre-frontal Cortex	SLC44A2	0.08	0.00	blup	365	0.01	1.4e-02	3.08	6.6	4.1e-11	0.25	0.07	0.09	TRUE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ICAM5	0.03	0.02	blup	48	0.02	4.5e-03	-10.54	-10.5	6.0e-26	-0.28	0.01	0.92	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	KRI1	0.32	0.15	enet	7	0.19	4.8e-08	6.95	-8.8	1.8e-18	0.00	0.60	0.03	FALSE
20	GTEx	Muscle Skeletal	KRI1	0.14	0.07	lasso	4	0.11	5.1e-11	6.99	-7.3	3.1e-13	0.02	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	KRI1	0.18	0.16	enet	8	0.15	1.9e-11	6.99	-7.2	7.7e-13	0.03	1.00	0.00	FALSE
22	GTEx	Skin Sun Exposed Lower leg	KRI1	0.23	0.05	lasso	8	0.16	3.5e-13	6.08	-7.0	1.8e-12	-0.09	0.99	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KRI1	0.30	0.39	lasso	3	0.38	1.7e-49	6.95	-7.0	3.3e-12	0.05	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	KRI1	0.12	0.16	lasso	5	0.16	1.4e-17	6.96	-6.7	1.6e-11	0.05	1.00	0.00	FALSE
8	GTEx	Brain Frontal Cortex BA9	ICAM3	0.40	0.13	lasso	8	0.22	1.3e-06	-4.70	6.7	1.8e-11	0.06	0.21	0.06	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	KRI1	0.05	0.04	blup	51	0.03	7.3e-05	-5.24	-6.7	1.9e-11	-0.01	0.25	0.62	FALSE
21	GTEx	Prostate	ZNF491	0.22	0.16	lasso	5	0.07	7.0e-03	-6.82	6.7	2.0e-11	0.04	0.01	0.86	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF441	0.02	0.02	blup	38	0.02	7.1e-04	-6.67	-6.7	2.4e-11	-0.05	0.01	0.91	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	KRI1	0.23	0.29	lasso	4	0.31	1.6e-30	6.96	-6.7	2.8e-11	0.04	1.00	0.00	FALSE
10	GTEx	Brain Hypothalamus	KRI1	0.29	0.17	lasso	3	0.20	1.5e-05	6.95	-6.6	3.3e-11	0.05	0.21	0.05	FALSE
4	GTEx	Adipose Visceral Omentum	S1PR2	0.23	0.01	lasso	5	0.01	1.1e-01	9.64	-6.6	4.3e-11	-0.59	0.02	0.66	FALSE
5	GTEx	Artery Aorta	KRI1	0.26	0.19	lasso	6	0.17	8.6e-10	6.99	-6.4	1.8e-10	0.06	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	KRI1	0.20	0.16	lasso	4	0.16	7.2e-10	6.99	-6.3	2.6e-10	0.05	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	KRI1	0.15	0.05	blup	51	0.06	1.2e-03	4.01	-6.3	3.0e-10	-0.01	0.07	0.07	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	S1PR5	0.06	0.02	blup	41	0.03	8.3e-04	-0.91	-6.3	3.5e-10	-0.03	0.01	0.70	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	ZNF441	0.20	0.12	lasso	5	0.12	1.4e-04	-6.08	-6.3	3.7e-10	-0.06	0.02	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	S1PR2	0.07	0.02	bslmm	369	0.03	5.3e-05	11.19	-6.2	4.0e-10	-0.49	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	KRI1	0.03	0.02	blup	52	0.03	4.0e-06	6.95	-6.1	1.4e-09	0.05	0.99	0.00	FALSE
9	GTEx	Brain Frontal Cortex BA9	KRI1	0.47	0.17	lasso	7	0.19	7.6e-06	6.99	-6.0	2.6e-09	0.06	0.41	0.03	FALSE
17	GTEx	Esophagus Mucosa	ZNF439	0.09	0.02	lasso	5	0.01	6.3e-02	-6.26	6.0	2.7e-09	0.05	0.06	0.76	FALSE
6	GTEx	Artery Tibial	KRI1	0.30	0.21	lasso	3	0.23	1.3e-17	6.99	-5.8	7.5e-09	0.06	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	P2RY11	0.22	0.00	lasso	9	0.00	8.4e-01	3.64	5.8	8.6e-09	0.42	0.06	0.11	FALSE
3	GTEx	Adipose Visceral Omentum	CTD-2369P2.2	0.20	0.00	lasso	4	0.00	3.2e-01	6.38	-5.7	1.1e-08	-0.65	0.02	0.54	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	KRI1	0.44	0.36	lasso	5	0.43	4.0e-60	6.99	-5.7	1.2e-08	0.05	1.00	0.00	FALSE
15	GTEx	Colon Sigmoid	KRI1	0.37	0.20	lasso	13	0.19	3.7e-07	6.99	-5.7	1.3e-08	0.03	0.68	0.02	FALSE
29	YFS	Blood	TMED1	0.22	0.19	lasso	5	0.19	5.2e-61	5.83	-5.6	1.9e-08	-0.09	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	ZNF440	0.16	0.07	enet	11	0.14	2.4e-10	-5.00	5.5	2.8e-08	0.06	0.05	0.95	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KRI1	0.05	0.05	blup	51	0.06	2.0e-07	6.96	-5.5	3.2e-08	0.05	0.99	0.00	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SLC44A2	0.09	-0.01	blup	59	0.03	1.1e-02	-2.71	5.3	1.2e-07	0.16	0.01	0.59	FALSE
7	GTEx	Brain Cortex	ICAM3	0.36	0.26	lasso	6	0.34	3.7e-10	5.32	5.2	1.5e-07	0.04	0.81	0.01	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDKN2D	0.03	0.02	blup	48	0.01	2.1e-02	6.96	-5.2	1.7e-07	0.07	0.24	0.03	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KRI1	0.06	0.06	lasso	1	0.06	5.3e-07	-5.22	-5.2	1.8e-07	-0.01	0.42	0.53	FALSE
12	GTEx	Cells Transformed fibroblasts	MRPL4	0.11	0.01	lasso	5	0.01	1.2e-01	-3.55	5.2	2.1e-07	0.16	0.24	0.06	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	ZNF439	0.21	0.13	lasso	9	0.15	3.8e-19	-5.00	5.2	2.1e-07	0.10	1.00	0.00	FALSE
23	GTEx	Testis	PDE4A	0.20	0.02	enet	39	0.04	6.4e-03	6.04	5.2	2.3e-07	-0.13	0.05	0.09	FALSE
16	GTEx	Esophagus Mucosa	SMARCA4	0.18	0.03	enet	15	0.09	8.2e-07	4.30	-5.2	2.6e-07	-0.04	0.95	0.00	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	KRI1	0.12	0.14	blup	52	0.14	3.4e-14	6.96	-5.1	2.9e-07	0.03	1.00	0.00	FALSE