Hub : Genes

ZNF440

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1570 0.0520 4.1e-05 0.066 NA 0.136 NA 0.111 1.1e-05 NA 2.4e-10 NA 1.2e-08
2 TCGA Breast Invasive Carcinoma 0.0488 0.0333 1.9e-04 0.025 0.022 0.007 NA 0.023 6.1e-06 1.9e-05 9.7e-03 NA 1.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.2 1.8 2.8 -0.9 1.7
Bipolar Disorder or Schizophrenia 0.1 0.1 0.2 0.5 0.2
Depressed Affect (Nagel 2018) 1.0 2.2 3.2 1.1 -1.8
Depression (Nagel 2018) 3.3 5.0 5.2 2.3 -2.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.4 1.2 -0.4
Neuroticism (Nagel 2018) 0.8 1.9 3.2 0.7 -1.8
Schizophrenia (2018) 0.9 1.8 2.4 1.6 -1.1
Schizophrenia vs Biploar Disorder 1.3 1.8 2.1 1.2 -1.4
Worry (Nagel 2018) 0.2 0.5 0.9 -0.2 -0.9
Alzheimer’s Disease (in mother) 0.4 0.5 0.5 -0.7 0.6
Alzheimer’s Disease (in father) 7.1 7.7 11.0 2.1 -3.3
Alzheimer’s Disease (including proxy) 0.5 0.7 1.3 0.2 -1.1
Crohns Disease (2017) 1.0 2.2 4.0 0.6 -2.0
Irritable Bowel Disease (IBD) 1.2 2.8 3.1 1.6 -1.8
Ulcerative Colitis (UC) 0.9 1.6 2.7 1.6 -0.8
Major Depression (MDD) 1.3 1.5 1.5 1.2 -1.2
Reaction Time 0.3 0.5 0.5 -0.7 0.7
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.3 -0.1 0.5
Breast Cancer 0.1 0.1 0.2 -0.2 0.5
Ovarian Cancer 1.4 1.8 2.9 1.7 -0.8
Prostate Cancer 0.8 1.2 1.4 -1.0 1.2
Age at First Birth 0.5 0.8 1.2 1.1 -0.6
Bipolar Disorder (2011) 0.6 0.6 1.1 0.0 1.1
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 -0.1 -0.1
Coronary Artery Disease (CAD) 0.5 0.6 0.8 0.9 -0.7
Crohns Disease (2012) 0.3 0.5 1.0 -0.3 -1.0
Mean Putamen Volume 0.1 0.1 0.1 0.1 0.3
Fasting Glucose 0.2 0.3 0.3 0.5 -0.6
HbA1C 0.7 0.8 0.9 -0.8 1.0
HDL Cholesterol 0.0 0.1 0.1 0.4 -0.0
LDL Cholesterol 2.9 4.7 5.3 -2.0 2.3
Lupus 0.0 0.0 0.1 -0.2 -0.2
Neuroticism (2016) 0.2 0.2 0.5 0.1 -0.7
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.7 -0.2
Rheumatoid Arthritis 0.1 0.1 0.2 0.4 0.3
Schizophrenia (2014) 0.6 1.4 2.0 1.4 -0.9
Triglycerides 1.2 1.9 2.0 -1.4 1.4
Type 2 Diabetes (T2D) (2012) 0.7 0.9 1.2 -0.7 1.1
Ulcerative Colitis 0.3 0.5 0.9 0.9 -0.3
Blood Eosinophil Count 2.5 19.2 19.2 4.4 -4.4
Blood Platelet Count 0.1 0.6 1.2 0.1 -1.1
Blood Red Count 0.5 4.6 5.9 2.4 -1.8
Blood White Count 5.2 38.5 46.1 5.5 -6.8
Heel T-Score 0.0 0.1 0.2 -0.5 -0.1
BMI 1.4 7.9 11.4 3.4 -2.1
Height 0.0 0.4 0.5 -0.7 0.6
Waist Hip Ratio (WHR) 0.7 3.0 4.2 -2.1 1.3
Systolic Blood Pressure 0.5 2.6 3.3 1.4 -1.8
Smoking Status 0.7 1.6 1.9 -1.1 1.4
Allergy or Eczema 0.3 0.9 1.1 -1.0 0.8
Cardiovascular Disease 0.1 0.4 0.6 0.4 0.8
Hypothyroidism (self reported) 0.1 0.1 0.2 -0.2 0.4
Respiratory disease 0.0 0.0 0.1 0.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.8 0.9 0.4
Lung FEV1/FVC ratio 1.6 8.2 9.1 2.7 -3.0
Lung FVC 0.7 3.5 5.4 -2.3 1.3
Neuroticism 0.3 0.6 1.2 -0.0 -1.1
Chronotype (morning person) 0.1 0.2 0.2 -0.4 0.4
Hair Pigment 0.0 0.8 0.9 -0.9 0.9
Tanning 0.1 1.1 1.3 -1.1 0.9
Hand grip strength (left) 0.5 1.4 2.0 -0.9 1.4
Number of treatments/medications taken 2.3 4.1 4.8 2.2 -1.8
Average weekly spirits intake 0.9 1.1 1.3 -1.1 0.9
Sensitivity / hurt feelings 1.1 1.9 2.6 -1.6 1.1
Frequency of depressed mood in last 2 weeks 2.6 3.6 4.4 2.1 -1.7
Hearing difficulty/problems: Yes 0.8 1.2 1.5 0.9 -1.2
Relative age of first facial hair 1.7 3.5 5.3 -2.3 1.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.0 -0.5 1.0
Ever used hormone-replacement therapy (HRT) 1.2 1.5 1.9 1.1 -1.4
Ever had hysterectomy (womb removed) 0.4 0.4 0.7 -0.4 0.8
Systolic blood pressure, automated reading 1.2 3.6 4.7 1.6 -2.2
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.0 1.0 -0.9
Angina 0.1 0.1 0.1 0.3 0.2
Medication for hormone replacement therapy 0.0 0.0 0.0 -0.2 0.0
Vitamin and mineral supplements 0.7 1.0 1.9 -0.4 1.4
Supplements: Zinc 5.4 5.9 7.5 2.1 -2.7
Medication: Co-codamol 0.1 0.1 0.3 0.2 0.5
Medication: Metformin 0.9 1.3 2.4 1.6 -0.5
Diabetes (father) 0.2 0.2 0.5 -0.0 0.7
Diabetes (mother) 2.6 3.4 3.4 1.8 -1.8
Severe depression (siblings) 0.0 0.0 0.0 -0.2 -0.2
Pack years adult smoking proportion 1.1 1.7 2.6 0.8 -1.6
Impedance of leg (right) 0.7 3.5 6.5 -2.5 0.8
Leg fat-free mass (left) 0.4 2.3 4.1 2.0 -0.7
Trunk fat percentage 0.5 2.0 2.4 1.5 -1.2
Hand grip strength (right) 1.1 2.9 3.1 -1.7 1.8
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.5 -0.3
Current tobacco smoking 0.0 0.1 0.1 -0.3 -0.0
Average weekly fortified wine intake 0.4 0.5 0.9 0.3 -1.0
Maternal smoking around birth 0.3 0.4 0.6 0.8 -0.4
Fed-up feelings 0.1 0.1 0.2 0.1 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 3.3 4.4 5.3 1.9 -2.3
Relative age voice broke 5.0 7.7 9.6 -3.1 2.4
Taking other prescription medications 0.5 0.8 1.5 1.2 -0.2
Age when periods started (menarche) 0.4 0.9 1.4 0.7 -1.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.6 0.8 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 3.4 -0.1 -1.8
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.7 0.9 -0.6
Qualifications: CSEs or equivalent 0.2 0.3 0.5 -0.7 0.1
Serious illness, injury or assault to yourself 0.1 0.1 0.1 0.4 0.1
High blood pressure 0.3 1.0 1.8 1.3 -0.3
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 -0.2 0.1
Multivitamins +/- minerals 1.4 1.8 2.5 1.0 -1.6
Stomach or abdominal pain in last month 0.1 0.1 0.1 -0.4 0.2
Supplements: Glucosamine 0.3 0.4 0.9 0.1 -0.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 -0.3 -0.2
Medication: Atenolol 0.1 0.1 0.1 0.3 0.3
Medication: Levothyroxine sodium 0.6 1.0 1.5 -0.7 1.2
Sitting height 0.0 0.1 0.2 0.5 -0.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.2 -0.5
High blood pressure (mother) 0.5 0.7 1.1 1.1 -0.5
Body mass index (BMI) 1.6 7.0 9.7 3.1 -2.1
Impedance of leg (left) 0.6 2.9 5.2 -2.3 0.7
Leg predicted mass (left) 0.5 2.4 4.2 2.1 -0.8
Trunk fat mass 0.7 2.9 4.0 2.0 -1.4
Waist circumference 1.2 4.4 5.9 2.4 -1.7
Number of incorrect matches in round 0.0 0.1 0.1 0.2 -0.3
Past tobacco smoking 0.5 0.9 1.4 0.6 -1.2
Alcohol usually taken with meals 0.1 0.2 0.3 0.1 -0.5
Nervous feelings 1.1 2.1 3.8 0.7 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 -0.5 -0.2
Hearing difficulty/problems with background noise 0.6 0.9 1.4 0.6 -1.2
Hair/balding pattern: Pattern 2 0.3 0.3 0.7 -0.8 0.1
Had menopause 1.4 1.8 2.0 -1.4 1.3
Had other major operations 1.5 1.9 2.2 1.2 -1.5
Forced vital capacity (FVC) 0.7 2.7 2.8 -1.7 1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 4.3 0.4 -2.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 1.4 1.2 -1.2
Qualifications: None of the above 0.1 0.2 0.4 -0.7 -0.2
Financial difficulties in last 2 years 0.4 0.5 0.5 0.7 -0.7
Mouth/teeth dental problems 0.4 0.6 1.0 -0.5 1.0
Heart attack 4.1 5.2 7.6 2.8 -1.7
Allergy 0.1 0.3 0.3 -0.5 0.6
Pain all over the body in last month 0.7 0.8 1.2 1.1 -0.6
Diabetes (self-reported) 0.2 0.2 0.5 0.7 0.1
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.1 1.5 -0.6
Medication: Ramipril 0.4 0.6 1.1 1.1 -0.1
Medication: Simvastatin 2.8 4.1 7.2 2.7 -1.0
Fluid intelligence score 0.2 0.4 0.6 -0.4 0.8
Illnesses of siblings 0.7 1.0 1.4 0.8 -1.2
Neuroticism score 0.2 0.5 0.8 -0.4 -0.9
Weight 0.9 4.4 6.6 2.6 -1.5
Impedance of arm (right) 0.6 2.8 4.8 -2.2 0.9
Arm fat percentage (right) 1.2 4.7 6.0 2.5 -1.8
Trunk fat-free mass 0.3 1.5 2.5 1.6 -0.7
Hip circumference 2.0 8.7 10.5 3.2 -2.6
Time employed in main current job 0.4 0.4 0.8 -0.0 0.9
Alcohol intake versus 10 years previously 1.5 2.2 2.2 1.5 -1.5
Father’s age at death 0.1 0.2 0.2 -0.4 0.5
Worrier / anxious feelings 0.2 0.3 0.6 -0.8 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.5 0.0
Falls in the last year 0.1 0.1 0.2 0.4 0.1
Hair/balding pattern: Pattern 3 1.2 1.8 2.0 1.3 -1.4
Number of live births 0.7 1.0 1.7 1.3 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.4 -0.6 0.5
Pulse rate 0.5 0.8 1.4 -1.2 0.5
Happiness 0.2 0.3 0.3 0.6 -0.5
Noisy workplace 0.3 0.4 0.5 0.7 -0.5
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.4 0.5 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 1.3 0.8 -1.1
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 0.3 -0.8
Asthma 0.0 0.1 0.1 0.3 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 -0.0 -0.0
Medication: Cholesterol lowering 0.7 1.2 2.2 1.5 0.3
Depression (self-reported) 0.1 0.1 0.1 -0.2 -0.3
Medication: Lansoprazole 0.8 0.9 1.3 1.2 -0.7
Prospective memory result 0.8 1.0 1.6 1.3 -0.6
Lung cancer (father) 1.9 2.2 3.1 1.1 -1.8
Illnesses of mother 2.5 3.1 5.2 -2.3 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 2.6 -1.6 1.1
Pulse wave Arterial Stiffness index 1.1 1.3 1.4 1.2 -1.1
Impedance of arm (left) 0.9 4.1 5.5 -2.3 1.7
Arm fat mass (right) 1.1 4.7 6.7 2.6 -1.7
Trunk predicted mass 0.2 1.4 2.4 1.6 -0.7
Standing height 0.1 0.6 0.8 -0.7 0.9
Length of working week for main job 4.4 4.8 6.8 1.7 -2.6
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.1 0.4
Breastfed as a baby 2.9 3.6 4.0 1.8 -2.0
Tense / ‘highly strung’ 0.3 0.5 1.1 -1.0 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.2 0.5
Hair/balding pattern: Pattern 4 0.0 0.0 0.0 -0.1 0.2
Birth weight of first child 0.1 0.1 0.2 -0.1 0.4
Peak expiratory flow (PEF) 0.0 0.1 0.1 0.3 -0.3
Pulse wave reflection index 2.5 3.1 3.6 1.6 -1.9
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.2 -0.2
Loud music exposure frequency 1.6 1.7 1.7 -1.3 1.3
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.0 -0.1 0.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 0.2 -0.6
Blood clot in the leg (DVT) 1.3 1.7 1.8 1.3 -1.2
Medication: Paracetamol 0.3 0.5 0.8 -0.9 0.4
Headache pain in last month 0.3 0.5 0.8 0.5 -0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.1 -1.0 -0.6
Glaucoma (self-reported) 0.2 0.2 0.3 -0.5 0.4
Gout (self-reported) 0.0 0.0 0.0 -0.1 0.0
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 0.2 0.1
Medication: Amlodipine 0.1 0.1 0.2 0.2 0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.4 0.3
Birth weight 0.1 0.3 0.5 0.7 0.4
Chronic bronchitis/emphysema (mother) 1.2 1.3 2.3 1.5 -0.6
High blood pressure (siblings) 0.1 0.1 0.2 0.2 0.5
Forced vital capacity (FVC), Best measure 1.1 4.1 4.8 -2.2 1.8
Body fat percentage 1.0 3.9 4.8 2.2 -1.7
Leg fat percentage (right) 1.2 4.2 4.9 2.2 -1.9
Arm fat-free mass (right) 0.5 2.3 3.8 1.9 -0.9
Exposure to tobacco smoke outside home 0.5 0.7 1.3 -0.2 1.2
Comparative body size at age 10 1.4 3.9 4.5 -1.8 2.1
Number of full brothers 0.1 0.1 0.1 0.3 0.1
Worry too long after embarrassment 0.3 0.4 0.6 -0.5 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.8 4.2 2.0 -1.2
Wheeze or whistling in the chest in last year 0.4 0.8 1.0 1.0 -0.7
Number of children fathered 0.4 0.4 0.6 0.5 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.0 1.0 -0.2
Age at first live birth 0.1 0.1 0.2 -0.4 0.2
Pulse wave peak to peak time 1.0 1.2 1.2 -1.1 1.1
Health satisfaction 0.0 0.1 0.1 -0.3 0.2
Shortness of breath walking on level ground 0.1 0.1 0.1 0.4 -0.2
Qualifications: College or University degree 0.1 0.2 0.5 0.7 0.1
Eye problems/disorders: None of the above 2.0 2.4 2.5 -1.6 1.5
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.3 0.2 -1.2
Emphysema/chronic bronchitis 0.6 0.7 1.1 1.1 -0.5
Medication for pain relief, constipation, heartburn 0.2 0.3 0.4 -0.6 0.6
Neck or shoulder pain in last month 0.0 0.0 0.1 -0.2 -0.1
Medication: Blood pressure 0.4 0.6 1.3 1.1 0.2
Angina (self-reported) 0.0 0.0 0.0 0.2 0.2
Migraine (self-reported) 0.2 0.2 0.4 -0.2 0.7
Medication: Ibuprofen 0.1 0.2 0.3 0.1 -0.6
Medication: Allopurinol 0.0 0.0 0.0 -0.1 0.1
Medication: Omeprazole 0.2 0.2 0.3 0.6 -0.3
Medication: Seretide 50 evohaler 0.2 0.2 0.4 0.6 0.1
Mean time to correctly identify matches 0.0 0.0 0.1 -0.0 0.2
Heart disease (mother) 0.3 0.4 0.7 0.8 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 -1.1 -0.2
Whole body fat mass 0.9 3.9 5.6 2.4 -1.5
Leg fat mass (right) 1.3 4.9 6.7 2.6 -1.7
Arm predicted mass (right) 0.4 1.9 3.3 1.8 -0.8
Pulse rate, automated reading 0.6 1.9 2.6 1.1 -1.6
Alcohol intake frequency. 0.6 1.3 1.3 1.1 -1.1
Comparative height size at age 10 0.2 1.3 1.6 1.3 -1.0
Number of full sisters 0.1 0.2 0.2 -0.4 -0.4
Suffer from ‘nerves’ 1.6 2.5 4.5 -2.1 0.8
Overall health rating 0.1 0.2 0.3 -0.2 -0.6
Chest pain or discomfort 0.1 0.1 0.2 -0.0 -0.4
Had major operations 0.0 0.0 0.0 0.1 0.1
Age at last live birth 0.1 0.1 0.2 0.2 -0.4
Family relationship satisfaction 0.3 0.4 0.7 0.3 -0.8
Leg pain on walking 2.3 2.9 3.4 1.9 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.1 0.1 -0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 0.9 0.9 -1.0
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 2.1 -1.5 1.5
Medication: Aspirin 0.1 0.1 0.2 -0.4 0.2
Supplements: Vitamin C 0.8 0.9 1.1 -1.1 0.8
Knee pain experienced in last month 3.3 5.1 5.8 2.1 -2.4
Hypertension (Self-reported) 0.2 0.6 1.1 1.0 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 1.0 -0.4
Illnesses of father: Heart disease 0.5 0.6 1.0 1.0 -0.6
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.3 -0.6
Smoking status: Previous 0.5 0.7 1.3 -0.4 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 0.0 0.0
Whole body fat-free mass 0.4 2.2 3.7 1.9 -0.9
Leg fat-free mass (right) 0.5 2.5 4.4 2.1 -0.8
Arm fat percentage (left) 1.1 4.3 6.1 2.5 -1.6
Average weekly red wine intake 0.1 0.1 0.2 0.5 -0.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.2 1.0 -1.1
Mood swings 0.3 0.6 0.7 0.7 -0.8
Loneliness, isolation 0.2 0.3 0.6 0.2 -0.8
Long-standing illness, disability or infirmity 2.4 3.6 3.9 1.8 -2.0
Ever had bowel cancer screening 0.2 0.2 0.5 0.0 -0.7
Diabetes diagnosed by doctor 0.8 1.4 2.5 1.6 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 -0.1 -0.1
Friendships satisfaction 0.3 0.4 0.5 0.7 -0.6
Qualifications: nursing, teaching 0.1 0.1 0.1 0.4 0.4
Commuting to job workplace: Walk 0.3 0.3 0.6 -0.8 0.2
Eye problems/disorders: Cataract 0.9 1.0 1.2 0.9 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 -0.2 -0.2
Medication for cholesterol 0.1 0.2 0.3 -0.6 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 2.5 1.2 -1.6
Back pain experienced in last month 0.0 0.0 0.1 -0.3 0.0
Mineral and other dietary supplements 0.4 0.5 0.9 1.0 -0.3
Breast cancer (self-reported) 1.6 1.9 2.7 1.6 -1.1
Asthma (self-reported) 0.1 0.1 0.1 0.4 -0.3
Osteoporosis (self-reported) 0.0 0.0 0.1 -0.2 0.1
Osteoarthritis (self-reported) 2.1 2.7 3.6 1.9 -1.3
Medication: Aspirin 0.1 0.2 0.2 -0.4 0.4
Medication: Gliclazide 4.7 5.4 7.0 2.6 -1.9
Illnesses of father: None of the above (group 1) 1.2 1.4 1.5 -1.2 1.2
Smoking status: Current 0.2 0.3 0.5 -0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.0 -1.0 0.1
Whole body water mass 0.3 1.9 3.2 1.8 -0.7
Leg predicted mass (right) 0.4 2.3 4.2 2.0 -0.7
Arm fat mass (left) 1.1 4.4 6.4 2.5 -1.6
Number of self-reported non-cancer illnesses 0.2 0.4 0.6 0.8 -0.4
Average weekly champagne plus white wine intake 1.3 1.8 2.0 -1.3 1.4
Miserableness 0.2 0.3 0.4 0.4 -0.6
Guilty feelings 0.1 0.2 0.4 -0.6 0.1
Wears glasses or contact lenses 0.2 0.2 0.4 0.6 -0.1
Ever taken oral contraceptive pill 0.4 0.4 0.5 0.7 -0.5
Hearing aid user 1.7 1.9 2.0 1.3 -1.4
Mother’s age at death 0.2 0.3 0.3 0.4 0.6
Financial situation satisfaction 0.2 0.3 0.3 -0.5 0.6
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.0 -0.1 0.2
Commuting to job workplace: Public transport 0.9 1.1 1.3 -1.2 1.0
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 -0.7 0.2
Medication: Blood pressure 0.0 0.0 0.1 0.3 -0.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.8 0.5 -0.9
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.1 -1.1 0.9
High cholesterol (Self-reported) 0.3 0.6 0.7 0.7 0.8
Medication: Bendroflumethiazide 0.7 1.0 1.2 -0.9 1.1
Medication: Paracetamol 0.0 0.1 0.1 -0.2 -0.3
Medication: Lisinopril 0.6 0.8 1.2 0.6 -1.1
Medication: Atorvastatin 0.1 0.1 0.2 -0.2 0.5
Illnesses of father: High blood pressure 0.7 0.9 1.3 1.1 -0.7
Alcohol drinker status: Never 0.6 0.7 1.1 0.5 -1.1
Ever smoked 0.3 0.6 0.8 -0.6 0.9
Basal metabolic rate 0.5 2.7 4.4 2.1 -1.0
Leg fat percentage (left) 1.4 5.1 6.2 2.5 -2.0
Arm fat-free mass (left) 0.6 2.9 4.1 2.0 -1.3
Number of operations (self-reported) 2.1 3.1 4.0 1.5 -2.0
Average weekly beer plus cider intake 0.5 0.7 1.5 0.1 1.2
Irritability 1.0 1.7 2.3 1.0 -1.5
Risk taking 1.4 2.0 2.5 1.6 -1.3
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 0.6 0.1
Fractured/broken bones in last 5 years 0.5 0.6 0.8 0.6 -0.9
Age started oral contraceptive pill 0.0 0.1 0.1 -0.3 -0.2
Diastolic blood pressure, automated reading 0.4 1.3 1.7 0.9 -1.3
Ever depressed for a whole week 1.0 1.2 1.8 -0.8 1.4
Unable to work because of sickness or disability 0.2 0.2 0.3 -0.4 0.5
Commuting to job workplace: Cycle 2.3 2.8 2.9 -1.6 1.7
Myopia 0.1 0.2 0.3 0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.7 1.8 3.0 -1.7 0.7
Cholesterol lowering medication 0.6 0.9 1.4 1.2 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 0.1 -0.1
Pain experienced in last month 1.1 1.8 1.9 -1.3 1.4
Supplements: Calcium 0.3 0.4 0.6 0.4 -0.8
Basal cell carcinoma (self-reported) 0.9 1.0 1.6 0.7 -1.3
Heart attack/myocardial infarction (self-reported) 3.5 4.6 6.5 2.5 -1.6
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 2.6 1.6 -1.4
Heart disease (siblings) 3.0 3.7 5.5 -1.4 2.3
Alcohol drinker status: Previous 2.1 2.4 2.8 -1.7 1.4
Pack years of smoking 1.1 1.7 2.6 0.8 -1.6
Impedance of whole body 0.8 3.9 6.5 -2.5 1.2
Leg fat mass (left) 1.3 5.1 7.0 2.6 -1.8
Arm predicted mass (left) 0.5 2.6 3.9 2.0 -1.2