Hub : Genes

ZNF491

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Prostate	0.220	0.0830	5.4e-03	0.164	NA	-0.008	NA	0.072	6.6e-05	NA	5.5e-01	NA	7.0e-03
2	GTEx	Thyroid	0.150	0.0460	8.7e-05	0.059	NA	0.081	NA	0.086	2.5e-05	NA	8.2e-07	NA	4.3e-07
3	YFS	Blood	0.015	0.0087	3.2e-02	-0.001	0.004	-0.001	0.004	0.000	9.4e-01	0.01800	6.5e-01	0.02	4.8e-01
4	TCGA	Pancreatic Adenocarcinoma	0.497	0.1650	1.9e-04	0.003	0.079	0.097	NA	0.053	2.4e-01	0.00032	7.0e-05	NA	2.9e-03
5	TCGA	Thyroid Carcinoma	0.054	0.0290	5.4e-03	0.048	0.024	0.034	NA	0.038	1.8e-05	0.00190	3.0e-04	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	2.7	-1.6	-1.4	-0.1	1.2	-0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	-0.5	0.0	0.5	1.3	1.3
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	1.8	1.0	0.3	-1.2	0.2
Depression (Nagel 2018)	0.7	1.1	4.5	2.1	0.2	-0.4	-0.8	-0.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.8	0.6	-0.7	-1.3	-1.9	-1.3
Neuroticism (Nagel 2018)	0.4	1.0	3.4	1.8	0.6	0.5	-0.8	-0.3
Schizophrenia (2018)	0.8	1.7	5.2	0.8	1.2	0.8	0.7	2.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	1.3	0.9	0.3	-0.9	0.5
Worry (Nagel 2018)	0.2	0.5	1.2	1.0	0.6	1.1	-0.3	-0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.6	-0.7	0.2	-0.4	-0.8
Alzheimer’s Disease (in father)	4.4	4.8	10.6	3.3	2.5	0.1	-1.7	2.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	1.2	0.6	-0.0	-0.9	0.3
Crohns Disease (2017)	0.7	1.5	3.4	1.8	-0.2	-1.4	-1.4	-0.4
Irritable Bowel Disease (IBD)	1.3	3.1	6.7	1.6	-1.0	-2.6	-1.7	-1.5
Ulcerative Colitis (UC)	1.5	2.9	5.8	0.7	-1.6	-2.4	-1.3	-2.0
Major Depression (MDD)	0.5	0.6	1.5	1.2	0.6	-0.2	-0.8	0.5
Reaction Time	0.1	0.2	0.6	-0.8	-0.4	0.1	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.5	-0.7	-0.0	-0.2	-0.6
Breast Cancer	0.1	0.3	0.9	-0.4	-0.4	0.9	-0.5	-0.1
Ovarian Cancer	0.3	0.5	1.0	0.8	0.2	-1.0	0.2	0.8
Prostate Cancer	0.6	0.8	1.6	-1.2	-0.7	-0.6	-0.8	-1.0
Age at First Birth	0.3	0.4	1.4	0.6	-0.4	-1.2	-0.1	0.1
Bipolar Disorder (2011)	0.4	0.4	1.2	0.0	0.0	0.0	1.1	-0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.2	-0.7	-0.8	-0.5	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	0.5	0.7	0.7	-0.1	0.5	0.7
Crohns Disease (2012)	0.3	0.5	0.9	0.9	-0.2	-0.9	-0.9	-0.0
Mean Putamen Volume	0.1	0.1	0.2	-0.4	-0.3	0.0	0.0	-0.4
Fasting Glucose	0.5	0.6	1.4	0.4	-1.0	-0.5	0.6	-1.2
HbA1C	1.3	1.4	4.0	-1.1	0.9	0.5	1.0	2.0
HDL Cholesterol	0.2	0.4	1.4	0.1	0.2	0.2	1.2	0.6
LDL Cholesterol	2.9	4.6	10.4	-2.4	-0.8	2.5	3.2	-0.4
Lupus	0.4	0.6	1.4	0.3	-0.2	0.9	-1.2	-0.7
Neuroticism (2016)	0.5	0.7	1.8	0.6	-0.6	0.6	-1.4	-0.9
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.2	0.1	-0.5	-0.5	-0.4
Rheumatoid Arthritis	1.2	1.6	4.1	-0.3	-2.0	0.1	0.8	-1.8
Schizophrenia (2014)	0.5	1.2	3.5	0.6	1.0	0.9	0.5	1.9
Triglycerides	0.8	1.3	3.3	-1.3	-0.6	0.7	1.8	-0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.6	-0.9	-0.9	-1.3	-0.8	-0.7
Ulcerative Colitis	0.8	1.2	2.3	0.2	-1.0	-1.5	-1.0	-1.2
Blood Eosinophil Count	0.9	7.1	19.7	4.4	-0.6	-2.0	-3.2	-1.3
Blood Platelet Count	0.5	5.7	9.0	1.1	2.2	3.0	2.9	2.2
Blood Red Count	0.1	0.8	3.0	1.7	0.5	-0.4	-0.1	0.9
Blood White Count	2.0	15.0	44.9	6.7	2.5	-2.1	-3.9	2.1
Heel T-Score	0.1	0.5	1.3	-0.1	-0.8	0.8	1.1	-0.3
BMI	0.3	1.9	4.8	1.9	-0.5	-2.2	-0.7	-0.8
Height	0.3	6.5	20.9	-0.3	-0.3	-4.6	-3.0	-1.6
Waist Hip Ratio (WHR)	0.3	1.4	2.7	-1.3	0.7	1.6	1.3	0.5
Systolic Blood Pressure	0.4	2.0	6.5	1.9	-0.1	-0.0	-2.5	-0.2
Smoking Status	0.7	1.8	3.2	-1.4	-1.2	0.7	1.8	-1.3
Allergy or Eczema	1.4	3.8	10.1	-0.7	-2.9	-0.3	0.0	-3.2
Cardiovascular Disease	0.2	0.6	1.3	-0.9	0.3	1.2	0.4	0.9
Hypothyroidism (self reported)	0.5	1.1	2.5	-0.3	1.0	0.8	1.1	1.6
Respiratory disease	0.5	1.2	3.1	0.1	-1.1	-1.8	1.1	-0.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	7.3	-0.4	-1.3	-2.7	-0.1	-1.2
Lung FEV1/FVC ratio	0.7	3.4	9.5	3.1	2.1	-0.3	-0.3	1.6
Lung FVC	0.5	2.6	10.5	-1.4	-0.2	3.2	0.7	0.0
Neuroticism	0.3	0.8	1.5	1.1	-0.2	0.5	-1.2	-1.0
Chronotype (morning person)	0.2	0.4	1.1	-0.2	0.8	1.0	0.7	0.2
Hair Pigment	0.1	2.3	5.4	-0.8	1.4	1.2	2.3	1.3
Tanning	0.0	0.2	0.5	-0.7	-0.3	0.2	-0.3	-0.4
Hand grip strength (left)	0.6	1.7	3.2	-1.4	-1.8	-0.9	0.7	-1.4
Number of treatments/medications taken	0.5	0.9	3.5	1.9	0.9	0.1	-0.2	0.5
Average weekly spirits intake	0.6	0.8	1.7	-0.9	-1.1	-0.3	-0.1	-1.3
Sensitivity / hurt feelings	0.3	0.5	1.1	-1.1	-0.7	-0.1	0.6	-0.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.8	1.7	1.2	0.2	0.1	0.9
Hearing difficulty/problems: Yes	0.2	0.3	1.1	1.1	-0.4	-0.5	0.1	0.0
Relative age of first facial hair	0.4	0.9	2.8	-1.2	0.2	-0.5	-1.7	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.0	-0.9	-1.2	-0.1	0.7	-1.4
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.6	1.4	1.6	0.3	-0.3	1.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.7	-0.1	-0.7	0.1	-0.2
Systolic blood pressure, automated reading	1.3	3.9	10.7	2.2	-1.0	-0.7	-3.3	-1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.3	0.9	1.1	-0.6	0.7	1.0
Angina	1.5	2.0	4.3	-0.3	1.3	1.5	1.3	2.1
Medication for hormone replacement therapy	0.9	1.0	2.2	-0.1	0.6	0.8	1.3	1.5
Vitamin and mineral supplements	0.9	1.2	2.2	-1.5	-1.2	-0.2	0.4	-1.4
Supplements: Zinc	3.3	3.6	8.3	2.9	1.2	-2.0	-1.7	1.2
Medication: Co-codamol	0.9	1.1	2.9	-0.7	-1.7	0.3	-0.1	-1.4
Medication: Metformin	0.8	1.1	4.7	0.4	-0.5	-2.2	0.6	-0.2
Diabetes (father)	0.2	0.2	0.4	-0.6	-0.4	-0.4	-0.1	-0.6
Diabetes (mother)	0.7	0.9	3.1	1.8	0.1	-0.9	-0.4	0.5
Severe depression (siblings)	0.2	0.2	0.3	0.3	-0.5	-0.0	-0.6	-0.6
Pack years adult smoking proportion	0.7	1.1	2.3	1.5	1.2	0.1	-0.7	1.2
Impedance of leg (right)	0.1	0.4	1.0	-0.7	0.7	1.0	-0.1	0.3
Leg fat-free mass (left)	0.3	1.7	6.9	0.8	-0.6	-2.6	-0.4	-0.6
Trunk fat percentage	0.2	0.7	2.0	1.0	-0.0	-1.4	-0.5	-0.1
Hand grip strength (right)	0.4	1.2	3.0	-1.7	-1.3	-0.3	0.4	-0.9
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.3	0.2	-0.3	-0.1	-0.5
Current tobacco smoking	0.9	1.5	2.9	0.0	1.5	1.7	1.0	1.2
Average weekly fortified wine intake	1.0	1.2	2.9	1.0	1.7	-0.5	-0.9	1.0
Maternal smoking around birth	0.7	1.0	1.8	0.4	-0.6	-1.0	-1.2	-1.3
Fed-up feelings	0.3	0.5	2.1	0.4	0.2	1.4	-0.4	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	5.3	2.3	1.1	0.6	0.1	0.7
Relative age voice broke	1.5	2.3	5.6	-2.4	-1.5	0.2	-0.5	-1.8
Taking other prescription medications	0.2	0.4	0.9	0.0	-0.7	0.3	0.6	-0.9
Age when periods started (menarche)	0.4	0.9	2.6	1.3	0.2	-1.6	-0.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	0.7	0.7	-0.2	-0.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	4.8	1.7	2.2	-0.4	-0.1	2.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	3.3	0.5	-1.0	-1.8	-0.9	-1.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.1	0.1	0.3	0.5	0.1
Serious illness, injury or assault to yourself	0.4	0.5	2.0	-0.0	0.1	-1.4	-0.6	-0.2
High blood pressure	0.1	0.3	0.6	0.2	-0.8	-0.3	-0.4	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.9	0.1	-1.5	-0.2	0.1	-2.0
Multivitamins +/- minerals	0.7	0.8	2.7	1.6	0.8	-0.0	-0.7	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.2	0.4
Supplements: Glucosamine	0.7	0.9	1.8	1.0	1.3	0.7	-0.3	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.0	0.1	0.6	-0.4	-1.0	0.1
Medication: Atenolol	0.1	0.2	0.3	-0.4	-0.2	0.6	0.4	0.4
Medication: Levothyroxine sodium	0.5	0.9	2.8	-1.1	0.1	1.7	0.8	0.2
Sitting height	0.1	0.9	4.2	0.5	0.4	-2.1	0.0	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	0.5	0.4	-0.8	0.7	0.5
High blood pressure (mother)	0.3	0.4	0.9	0.4	1.0	-0.2	-0.9	0.5
Body mass index (BMI)	0.4	1.6	3.6	1.8	-0.7	-1.9	-0.8	-0.5
Impedance of leg (left)	0.1	0.7	1.7	-0.7	1.0	1.3	-0.1	0.5
Leg predicted mass (left)	0.3	1.7	6.9	0.8	-0.5	-2.6	-0.4	-0.5
Trunk fat mass	0.3	1.4	4.9	1.2	-0.3	-2.2	-0.7	-0.4
Waist circumference	0.7	2.4	5.8	1.5	-0.9	-2.4	-1.3	-1.1
Number of incorrect matches in round	0.4	0.7	1.6	0.2	-0.6	1.3	-0.8	-1.0
Past tobacco smoking	2.1	3.9	8.3	1.3	2.8	1.4	0.0	2.9
Alcohol usually taken with meals	1.0	1.7	5.4	0.6	1.0	-2.3	-0.0	1.3
Nervous feelings	0.9	1.6	3.8	2.0	0.6	0.4	-1.9	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	0.2	-0.6	1.1	0.4	-1.3
Hearing difficulty/problems with background noise	0.2	0.4	1.1	1.1	0.2	0.1	0.5	0.6
Hair/balding pattern: Pattern 2	2.0	2.5	3.9	-0.1	1.9	2.0	1.1	2.0
Had menopause	0.7	0.9	2.2	-1.2	-0.3	1.5	0.5	-0.7
Had other major operations	0.8	1.0	2.4	1.5	0.5	-1.6	-0.2	0.2
Forced vital capacity (FVC)	0.1	0.5	1.9	-1.4	-0.1	0.5	0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	6.8	2.0	2.6	0.2	-0.3	2.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	1.1	-0.8	-0.0	-0.1	-0.8
Qualifications: None of the above	0.3	0.6	1.6	0.2	1.3	0.4	0.0	1.1
Financial difficulties in last 2 years	0.2	0.3	0.5	0.7	0.7	0.4	-0.1	0.5
Mouth/teeth dental problems	0.3	0.5	0.9	-0.9	-0.9	0.1	-0.2	-0.9
Heart attack	0.9	1.1	2.6	1.6	1.1	-0.3	-0.4	1.2
Allergy	0.3	0.6	1.3	-0.7	0.5	1.1	-0.1	0.9
Pain all over the body in last month	0.4	0.4	1.4	0.8	0.2	-1.2	0.3	0.1
Diabetes (self-reported)	0.6	1.0	3.6	-0.1	-0.2	-1.9	1.1	0.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.9	0.8	-1.5	-0.6	0.1	-2.0
Medication: Ramipril	0.1	0.1	0.3	-0.1	-0.5	-0.0	0.3	-0.0
Medication: Simvastatin	1.0	1.5	2.8	0.9	-1.3	-1.7	-0.9	-1.2
Fluid intelligence score	0.3	0.6	1.4	-0.8	-0.8	0.0	-1.2	-0.6
Illnesses of siblings	1.2	1.6	3.1	1.3	1.7	-0.3	-1.7	0.7
Neuroticism score	0.3	0.7	1.1	1.0	0.8	1.0	-0.7	-0.2
Weight	0.5	2.7	9.5	1.4	-0.7	-3.1	-1.1	-0.7
Impedance of arm (right)	0.1	0.4	0.6	-0.8	0.6	0.6	-0.5	0.7
Arm fat percentage (right)	0.4	1.5	3.2	1.5	-0.6	-1.8	-1.1	-0.3
Trunk fat-free mass	0.4	2.3	8.5	0.8	-0.6	-2.9	-1.2	-0.8
Hip circumference	1.0	4.4	11.2	2.5	-0.1	-3.4	-2.1	-0.4
Time employed in main current job	1.2	1.4	4.1	-0.9	-1.2	-0.4	2.0	-0.6
Alcohol intake versus 10 years previously	0.9	1.3	2.1	1.4	1.4	0.2	1.0	1.2
Father’s age at death	0.2	0.3	0.7	-0.5	0.3	0.3	0.5	0.8
Worrier / anxious feelings	0.3	0.5	1.0	0.1	-0.2	0.8	1.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.0	-0.0	-1.1	0.6	-0.2	-1.4
Falls in the last year	0.6	0.8	2.3	-0.1	0.1	1.2	1.5	0.6
Hair/balding pattern: Pattern 3	0.9	1.3	4.3	1.4	-0.3	-2.1	0.1	-0.4
Number of live births	0.4	0.6	1.1	0.6	-0.4	-0.8	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	-0.3	0.4	0.3	0.8	0.8
Pulse rate	0.3	0.5	1.0	-0.6	-0.9	0.3	-0.1	-1.0
Happiness	1.0	1.2	2.8	0.5	-1.4	-0.9	-0.3	-1.7
Noisy workplace	0.4	0.5	1.6	0.3	0.2	-0.5	0.6	1.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.7	1.3	0.6	-0.2	-0.7	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	1.1	-0.2	-1.1	0.3	0.7
Mouth/teeth dental problems: Dentures	0.4	0.8	1.8	0.8	0.9	0.4	-1.3	0.5
Asthma	0.2	0.3	0.6	0.3	-0.8	-0.7	0.5	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.1	-0.4	0.4	0.7	-0.7
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.4	-0.1	-0.0	0.5	0.2
Depression (self-reported)	0.3	0.4	0.9	0.4	0.3	0.7	-1.0	-0.3
Medication: Lansoprazole	0.2	0.2	0.5	0.7	0.4	-0.3	-0.7	0.2
Prospective memory result	0.6	0.8	1.7	0.5	-0.5	-1.3	-1.3	-0.3
Lung cancer (father)	0.6	0.8	3.1	1.8	0.6	0.3	-0.4	-0.3
Illnesses of mother	0.8	1.0	3.2	-1.0	0.5	0.3	1.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.0	-0.9	-0.1	-0.0	1.4	0.5
Pulse wave Arterial Stiffness index	1.0	1.1	3.6	1.1	0.1	-1.9	-0.8	-0.2
Impedance of arm (left)	0.2	1.0	2.4	-1.6	0.6	1.2	0.4	0.7
Arm fat mass (right)	0.4	1.5	4.4	1.4	-0.5	-2.1	-0.9	-0.3
Trunk predicted mass	0.4	2.3	8.4	0.8	-0.6	-2.9	-1.2	-0.9
Standing height	0.2	2.1	9.2	-0.5	0.2	-3.0	-0.9	-0.4
Length of working week for main job	2.0	2.2	6.8	2.6	1.6	-0.5	0.1	1.2
Exposure to tobacco smoke at home	0.1	0.2	0.4	-0.5	-0.3	-0.3	0.6	-0.2
Breastfed as a baby	1.8	2.2	3.8	1.9	1.5	-1.5	-1.2	1.3
Tense / ‘highly strung’	0.4	0.7	2.2	-0.1	-0.9	0.5	0.2	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.1	-0.5	-1.2	0.3	-0.8	-1.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	-0.2	-0.5	0.0	-0.8	-0.7
Birth weight of first child	0.1	0.2	0.5	-0.3	-0.5	0.3	-0.4	-0.7
Peak expiratory flow (PEF)	0.2	0.5	0.8	0.6	0.7	-0.9	0.7	0.5
Pulse wave reflection index	1.3	1.6	3.6	1.9	0.1	-1.9	-0.8	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.2	-0.1	-0.7	-0.7	-0.2
Loud music exposure frequency	0.5	0.6	1.6	-1.3	0.0	0.9	-0.3	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.5	-0.3	-1.6	0.4	0.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.5	0.0	-0.2	-0.3	-0.1
Blood clot in the leg (DVT)	1.3	1.6	3.6	1.3	0.9	-1.9	-1.3	0.3
Medication: Paracetamol	0.4	0.6	2.2	-0.5	-0.1	1.5	0.6	0.3
Headache pain in last month	0.4	0.6	0.9	1.0	1.0	0.9	-0.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	0.7	1.1	0.6	0.0	0.7
Glaucoma (self-reported)	0.6	0.7	2.5	-0.5	-0.7	0.1	1.6	-0.5
Gout (self-reported)	0.3	0.4	1.5	0.0	0.3	-1.2	-0.7	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.0	0.4	1.1	0.5	0.4
Medication: Amlodipine	0.2	0.3	0.5	-0.5	0.1	0.0	0.7	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	-0.2	-0.3	0.7	1.2	-0.4
Birth weight	0.4	0.8	1.7	-0.4	-1.3	-1.0	0.1	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	0.6	0.7	0.3	0.9	0.8
High blood pressure (siblings)	0.6	0.9	2.8	-0.6	-1.7	-0.5	-0.0	-1.1
Forced vital capacity (FVC), Best measure	0.2	0.8	2.5	-1.6	-0.5	0.1	1.1	-0.0
Body fat percentage	0.3	1.2	2.8	1.4	-0.3	-1.7	-1.0	-0.4
Leg fat percentage (right)	0.6	2.2	4.6	1.5	-0.9	-2.1	-1.5	-1.1
Arm fat-free mass (right)	0.2	1.1	4.2	1.0	-0.2	-2.0	-0.2	-0.6
Exposure to tobacco smoke outside home	3.4	4.6	11.4	-1.2	-3.4	-0.8	-1.3	-2.8
Comparative body size at age 10	0.7	1.8	4.3	-2.1	-0.4	1.2	1.8	0.1
Number of full brothers	0.5	0.6	2.1	-0.1	0.4	-0.6	0.7	1.4
Worry too long after embarrassment	0.4	0.8	2.3	0.8	0.9	1.5	0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.9	1.2	-0.2	-0.7	-1.7	-1.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.7	-0.0	0.3	0.6	-0.3
Number of children fathered	1.3	1.4	3.1	0.7	1.7	0.3	0.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.2	0.2	-1.5	0.0	-1.3	-1.4
Age at first live birth	0.3	0.5	1.4	-0.2	-0.5	-1.2	0.8	0.3
Pulse wave peak to peak time	0.7	0.9	2.7	-1.1	-0.2	1.6	0.6	0.0
Health satisfaction	1.1	1.4	6.1	-0.2	-0.8	0.3	2.5	-0.4
Shortness of breath walking on level ground	0.4	0.4	1.4	0.3	-0.6	-1.2	0.2	-0.6
Qualifications: College or University degree	0.4	1.4	6.0	0.1	-0.6	-2.4	-0.6	-0.4
Eye problems/disorders: None of the above	1.1	1.3	2.5	-1.6	0.0	1.0	1.5	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.2	1.0	-1.1	-0.6	-0.5	-0.9
Emphysema/chronic bronchitis	0.5	0.6	1.4	0.5	0.3	-1.0	1.2	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.6	-0.1	-0.4	-0.2	0.1
Neck or shoulder pain in last month	0.1	0.2	0.4	0.0	-0.6	0.1	0.6	-0.4
Medication: Blood pressure	0.1	0.2	0.6	-0.2	-0.8	-0.1	0.4	-0.4
Angina (self-reported)	1.5	2.0	4.2	-0.2	1.4	1.5	1.2	2.0
Migraine (self-reported)	0.2	0.2	0.4	-0.6	0.2	-0.6	0.4	-0.0
Medication: Ibuprofen	0.6	0.7	1.6	0.6	0.6	1.0	1.2	0.3
Medication: Allopurinol	0.1	0.2	0.7	-0.1	0.4	-0.8	-0.3	-0.1
Medication: Omeprazole	0.1	0.1	0.2	0.2	0.3	-0.1	0.3	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.1	-0.2	-0.4	0.1	-0.4
Mean time to correctly identify matches	0.2	0.4	1.0	-0.4	-0.8	0.1	-0.6	-1.0
Heart disease (mother)	0.3	0.3	0.9	-0.0	-0.7	-0.3	-0.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	0.2	0.3	1.0	0.4	-0.2
Whole body fat mass	0.4	1.6	5.0	1.2	-0.5	-2.2	-0.9	-0.6
Leg fat mass (right)	0.7	2.6	7.2	1.5	-1.0	-2.7	-1.3	-1.0
Arm predicted mass (right)	0.3	1.3	4.9	0.8	-0.5	-2.2	-0.4	-0.8
Pulse rate, automated reading	0.7	2.2	3.3	1.5	-1.1	-1.1	-1.8	-1.7
Alcohol intake frequency.	0.3	0.7	1.3	1.1	1.0	0.1	0.3	1.1
Comparative height size at age 10	0.3	1.5	3.2	1.3	1.3	-1.8	-0.6	0.9
Number of full sisters	0.3	0.4	0.7	0.5	-0.2	0.9	-0.6	-0.8
Suffer from ‘nerves’	1.0	1.6	7.4	-0.7	0.4	2.7	-0.1	-0.4
Overall health rating	1.0	2.2	4.3	0.4	1.2	2.1	1.8	1.3
Chest pain or discomfort	0.2	0.3	0.6	0.4	0.8	0.7	0.1	0.7
Had major operations	0.3	0.3	0.8	-0.2	-0.9	0.2	0.5	-0.7
Age at last live birth	0.7	1.0	4.8	0.4	-0.3	-2.2	-0.3	0.0
Family relationship satisfaction	1.0	1.2	2.1	0.7	-0.9	-0.7	-1.4	-1.4
Leg pain on walking	1.3	1.6	2.6	1.6	1.6	-0.5	0.9	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	4.2	-0.3	1.7	1.6	1.2	2.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	1.0	-0.1	-0.6	-0.5	0.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.3	-1.5	0.1	1.8	1.2	0.1
Medication: Aspirin	0.3	0.4	1.5	-0.2	-0.0	0.3	1.2	0.6
Supplements: Vitamin C	0.1	0.1	0.5	-0.7	-0.3	0.2	-0.0	0.2
Knee pain experienced in last month	1.5	2.3	6.0	2.4	1.3	-1.6	-0.2	1.1
Hypertension (Self-reported)	0.0	0.1	0.3	0.2	-0.5	-0.0	-0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.5	0.2	0.2	0.4	0.5
Illnesses of father: Heart disease	0.7	1.0	1.4	0.6	1.1	0.9	-1.1	1.2
Illnesses of siblings: Diabetes	0.5	0.6	1.5	0.5	-1.2	-1.0	-0.3	-0.6
Smoking status: Previous	2.9	4.3	9.2	-1.2	-2.8	-1.5	-0.5	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	0.1	0.9	0.2	1.5	1.2
Whole body fat-free mass	0.4	2.1	8.0	1.0	-0.5	-2.8	-0.9	-0.8
Leg fat-free mass (right)	0.3	1.4	5.9	0.8	-0.2	-2.4	-0.5	-0.3
Arm fat percentage (left)	0.2	1.0	2.4	1.3	-0.5	-1.5	-0.7	-0.2
Average weekly red wine intake	0.3	0.5	1.5	0.1	-0.1	-0.9	-1.2	0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.8	1.1	0.6	-1.4	-1.3	0.6
Mood swings	0.4	0.7	1.3	0.9	1.1	1.0	0.4	0.6
Loneliness, isolation	0.4	0.6	2.2	0.8	0.2	1.5	-0.1	-0.4
Long-standing illness, disability or infirmity	0.7	1.0	4.3	2.1	0.8	-0.0	-0.2	0.3
Ever had bowel cancer screening	0.2	0.2	0.5	0.7	0.4	0.0	-0.2	-0.4
Diabetes diagnosed by doctor	0.7	1.2	5.3	0.5	0.0	-2.3	0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	0.2	-0.1	-0.9	0.2	0.4
Friendships satisfaction	2.3	2.9	6.4	0.4	-2.5	-0.9	-1.3	-2.3
Qualifications: nursing, teaching	1.4	2.2	4.8	-0.4	-1.7	-0.8	-1.6	-2.2
Commuting to job workplace: Walk	0.3	0.4	0.9	-0.1	0.9	0.5	-0.7	0.5
Eye problems/disorders: Cataract	1.4	1.6	4.3	1.3	0.1	-1.1	-2.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	0.3	-0.7	-0.8	1.1	-0.8
Medication for cholesterol	0.1	0.2	0.8	-0.0	-0.2	0.4	0.2	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	1.9	3.8	1.6	1.3	-0.8	-2.0	1.0
Back pain experienced in last month	0.8	1.2	3.0	-0.1	-1.7	-0.3	-0.1	-1.6
Mineral and other dietary supplements	0.3	0.4	1.7	0.1	-0.1	-0.1	1.3	0.3
Breast cancer (self-reported)	0.4	0.5	1.1	1.1	0.7	-0.1	-0.4	0.8
Asthma (self-reported)	0.3	0.6	1.6	0.4	-0.9	-1.3	0.4	-0.6
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.2	-0.7	0.5	-0.9	-0.5
Osteoarthritis (self-reported)	0.9	1.2	2.9	1.3	-0.4	-1.7	-0.6	-0.9
Medication: Aspirin	0.5	0.6	1.7	-0.4	0.2	0.8	1.3	0.8
Medication: Gliclazide	1.3	1.5	3.4	1.8	-0.6	-1.7	0.3	-1.0
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	-1.2	-1.2	-0.3	1.2	-0.7
Smoking status: Current	1.4	2.3	4.1	-0.4	1.3	2.0	1.9	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	-0.2	-0.2	0.7	0.1	0.1
Whole body water mass	0.3	1.9	7.3	0.8	-0.5	-2.7	-0.8	-0.7
Leg predicted mass (right)	0.3	1.4	5.9	0.7	-0.3	-2.4	-0.5	-0.3
Arm fat mass (left)	0.3	1.4	4.3	1.3	-0.5	-2.1	-0.6	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.5	0.2	0.0	0.5	-0.5
Average weekly champagne plus white wine intake	0.6	0.8	2.1	-1.4	-1.1	-0.7	0.4	-0.1
Miserableness	0.3	0.5	1.2	0.7	0.8	1.1	-0.5	0.3
Guilty feelings	0.2	0.3	1.2	-0.1	-0.2	0.5	-0.2	-1.1
Wears glasses or contact lenses	0.8	0.9	2.5	0.2	-0.7	-0.7	-0.9	-1.6
Ever taken oral contraceptive pill	0.7	0.7	1.7	0.6	0.8	-1.0	-0.3	1.3
Hearing aid user	1.6	1.8	4.1	1.4	2.0	0.4	-0.6	1.5
Mother’s age at death	0.3	0.4	1.1	-0.6	-0.4	-0.5	-1.1	-0.4
Financial situation satisfaction	0.5	0.6	1.2	-0.5	-1.0	-0.3	0.6	-1.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	-0.2	-0.9	-0.3	-0.5	-0.1
Commuting to job workplace: Public transport	0.7	0.9	1.9	-1.0	-0.7	0.5	1.4	-0.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.2	-0.4	-0.7	0.4	-0.3
Medication: Blood pressure	0.1	0.3	0.6	0.1	0.4	-0.7	-0.7	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	0.9	0.9	0.3	0.9	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.8	-0.1	-0.0	-1.2	-0.7
High cholesterol (Self-reported)	0.3	0.5	0.9	-0.9	-0.9	0.7	0.7	-0.2
Medication: Bendroflumethiazide	0.4	0.5	1.4	-1.2	-0.5	-0.0	0.8	-0.5
Medication: Paracetamol	0.7	1.1	2.6	0.3	0.9	1.6	1.0	1.1
Medication: Lisinopril	0.7	0.9	1.5	1.2	1.2	-0.4	-0.7	1.0
Medication: Atorvastatin	1.6	1.9	4.5	-0.5	1.5	0.6	1.5	2.1
Illnesses of father: High blood pressure	1.4	1.8	4.1	0.7	2.0	1.6	-0.5	1.2
Alcohol drinker status: Never	0.6	0.7	1.1	1.1	0.5	-0.9	-1.0	0.4
Ever smoked	1.3	2.3	4.8	-1.0	-2.1	-1.2	-0.1	-2.2
Basal metabolic rate	0.4	2.2	8.5	1.0	-0.6	-2.9	-0.8	-0.7
Leg fat percentage (left)	0.5	2.0	3.6	1.7	-0.6	-1.9	-1.6	-0.8
Arm fat-free mass (left)	0.4	1.9	6.7	1.3	-0.5	-2.6	-0.8	-0.7
Number of operations (self-reported)	0.8	1.1	3.7	1.9	0.9	-0.9	-0.5	0.4
Average weekly beer plus cider intake	0.9	1.3	4.5	-1.2	0.2	-0.1	2.1	0.6
Irritability	0.6	1.1	2.4	1.5	1.1	0.3	-1.2	0.4
Risk taking	0.5	0.7	1.4	1.2	0.9	0.1	-0.4	1.0
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.3	-0.1	-1.7	-1.7	-1.2	-2.1
Fractured/broken bones in last 5 years	0.8	1.0	3.3	0.9	0.0	-1.0	-1.8	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	0.1	0.3	0.5	-0.2	-0.0
Diastolic blood pressure, automated reading	1.8	5.5	10.9	1.3	-2.6	-1.0	-2.7	-3.3
Ever depressed for a whole week	1.7	2.1	5.5	-1.4	-2.4	0.3	0.2	-1.6
Unable to work because of sickness or disability	1.1	1.5	2.9	-0.5	1.1	1.7	1.0	1.5
Commuting to job workplace: Cycle	1.2	1.5	3.0	-1.7	-1.5	0.3	0.9	-1.1
Myopia	0.8	1.2	3.2	0.2	-1.5	0.3	-0.6	-1.8
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.6	0.3	0.0	0.6	0.2
Cholesterol lowering medication	0.1	0.1	0.3	0.5	0.1	0.3	0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.1	0.0	-0.6	0.0	-0.2
Pain experienced in last month	0.3	0.6	1.9	-1.4	-0.5	0.5	-0.6	-0.3
Supplements: Calcium	0.4	0.4	1.0	0.8	0.3	0.4	-1.0	0.0
Basal cell carcinoma (self-reported)	1.4	1.6	3.6	1.3	1.9	0.4	-1.0	1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.5	1.6	1.2	-0.2	-0.2	1.3
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.5	1.5	1.1	-2.1	-1.4	0.6
Heart disease (siblings)	1.9	2.3	5.3	-2.3	-1.2	0.9	1.9	-0.7
Alcohol drinker status: Previous	0.7	0.8	2.2	-1.5	-0.2	1.3	0.1	0.1
Pack years of smoking	0.7	1.0	2.3	1.5	1.1	0.0	-0.4	1.2
Impedance of whole body	0.2	1.0	1.5	-1.1	1.2	1.2	0.0	0.9
Leg fat mass (left)	0.5	2.1	5.8	1.5	-0.6	-2.4	-1.3	-0.7
Arm predicted mass (left)	0.3	1.6	5.7	1.2	-0.3	-2.4	-0.8	-0.5