TWAS hub - S1PR5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0475	0.0144	3.2e-06	0.019	0.019	0.027	0.02	0.022	4.9e-07	3.9e-07	2.0e-09	2.9e-07	8.6e-08
2	TCGA	Bladder Urothelial Carcinoma	0.0500	0.0240	1.6e-03	0.039	0.028	0.035	NA	0.036	2.9e-04	1.9e-03	5.6e-04	NA	5.2e-04
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0721	0.0293	6.7e-06	0.069	0.052	0.052	NA	0.061	3.2e-08	1.5e-06	1.5e-06	NA	2.2e-07
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0427	0.0223	2.2e-03	0.044	0.027	0.030	NA	0.034	8.8e-06	4.7e-04	2.2e-04	NA	9.6e-05
5	TCGA	Pancreatic Adenocarcinoma	0.1470	0.0710	9.2e-03	-0.007	0.031	0.030	NA	-0.005	9.0e-01	1.8e-02	2.1e-02	NA	6.0e-01
6	TCGA	Prostate Adenocarcinoma	0.1304	0.0420	3.7e-10	0.117	0.118	0.112	NA	0.115	3.1e-12	2.4e-12	1.0e-11	NA	5.4e-12
7	TCGA	Thyroid Carcinoma	0.0630	0.0330	4.1e-03	0.016	0.028	0.025	NA	0.027	9.8e-03	8.3e-04	1.4e-03	NA	1.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ever taken oral contraceptive pill	5.2	5.7	12.4	-3.5	0.7	2.5	2.7	2.9	2.1	0.8
Crohns Disease (2012)	5.0	8.0	27.1	-1.3	-5.2	-2.5	-2.2	-0.8	-2.2	-3.2
Had other major operations	4.3	5.2	8.5	-1.3	2.8	2.1	2.2	2.9	2.1	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	4.2	13.3	21.6	-1.7	4.2	3.2	3.5	3.8	3.6	4.7
Peak expiratory flow (PEF)	4.2	9.7	13.6	-2.0	3.7	3.3	3.3	2.7	3.4	3.0
Medication for cholesterol, blood pressure or diabetes	4.2	6.9	12.0	-0.8	3.1	2.5	2.4	2.9	2.3	3.5
Medication: Gliclazide	4.2	4.8	7.4	-1.6	1.6	2.3	2.5	2.7	2.7	1.5
Cholesterol lowering medication	3.9	5.7	10.5	-3.0	3.2	2.6	2.7	1.6	2.1	0.4
Emphysema/chronic bronchitis	3.8	4.3	7.8	0.6	-1.3	-1.9	-2.1	-2.6	-2.8	-2.4
Medication: Blood pressure	3.8	6.7	12.3	1.0	-2.0	-2.6	-2.8	-3.0	-2.5	-3.5
Knee pain experienced in last month	3.8	5.9	13.2	-0.6	3.4	1.4	1.7	2.6	2.1	3.6
Medication: Omeprazole (e.g. Zanprol)	3.8	4.6	7.0	0.5	-1.9	-2.1	-2.3	-2.1	-2.7	-2.7
Forced expiratory volume in 1-second (FEV1)	3.4	11.4	18.8	-1.6	3.7	3.0	3.3	3.5	3.5	4.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.1	9.1	-3.0	2.2	2.9	2.9	2.8	2.7	2.1
Crohns Disease (2017)	3.2	7.0	30.7	-1.7	-5.5	-1.4	-1.2	0.0	-2.4	-2.5
Suffer from ‘nerves’	3.2	5.0	8.0	-0.4	2.0	2.2	2.3	2.6	2.5	2.8
Average weekly fortified wine intake	3.1	3.7	9.5	0.9	-1.4	-1.2	-1.6	-2.8	-1.2	-3.1
Forced vital capacity (FVC), Best measure	2.8	10.3	21.5	-1.3	3.4	2.8	3.1	3.2	3.0	4.6
Heart attack/myocardial infarction (self-reported)	2.8	3.6	5.7	1.4	-1.6	-2.4	-2.3	-1.7	-1.8	-1.8
Bipolar Disorder (2018)	2.7	4.2	8.1	1.6	-2.8	-1.6	-1.9	0.0	-2.9	-2.2
Mouth/teeth dental problems: Bleeding gums	2.6	3.4	6.6	-1.8	2.6	1.5	1.5	1.6	1.3	2.2
Primary Biliary Cirrhosis	2.4	3.5	9.2	-3.0	0.9	1.6	2.3	0.0	2.2	1.2
Taking other prescription medications	2.4	3.7	6.7	0.5	-2.1	-2.3	-2.1	-1.8	-1.3	-2.6
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	11.1	-1.9	-1.2	1.2	1.3	3.3	0.8	-0.1
Irritable Bowel Disease (IBD)	2.3	5.5	30.0	-1.1	-5.5	-0.8	-0.5	0.9	-1.2	-2.1
Supplements: Glucosamine	2.3	3.0	6.0	1.8	-0.3	-2.4	-2.3	-1.1	-2.3	-0.0
Forced vital capacity (FVC)	2.3	8.8	18.7	-1.0	3.0	2.7	3.0	2.9	2.9	4.3
Heart attack	2.3	2.9	4.7	1.2	-1.5	-2.2	-2.1	-1.5	-1.6	-1.7
Birth weight of first child	2.3	4.2	8.1	-1.4	0.6	2.1	2.2	2.8	1.9	2.5
Pain type(s) experienced in last month: Hip pain	2.3	2.8	4.5	-0.8	1.3	2.0	1.7	2.1	1.7	1.8
Lung FEV1/FVC ratio	2.2	11.2	18.1	-3.7	2.9	3.2	3.4	4.3	3.7	1.5
Had menopause	2.2	2.8	4.5	1.3	0.1	-1.9	-2.0	-2.1	-1.7	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	11.2	0.3	0.2	1.6	2.0	3.3	1.8	3.2
Medication: Co-codamol	2.0	2.3	4.8	-0.8	0.8	2.2	2.2	1.4	1.7	-0.6
Medication: Atenolol	2.0	2.5	6.6	1.1	-1.1	-1.4	-1.4	-2.1	-0.8	-2.6
Medication: Ibuprofen	2.0	2.4	3.8	-1.1	1.9	1.9	1.8	0.8	1.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	5.6	1.2	-0.8	-1.3	-1.5	-2.4	-1.7	-1.5
Pulse rate, automated reading	2.0	6.5	10.8	-3.3	1.2	2.5	2.8	3.2	2.9	0.5
Medication: Cholesterol lowering	1.9	3.0	9.9	-0.6	-1.9	-1.2	-1.0	-1.6	-1.4	-3.1
Leg pain on walking	1.9	2.4	8.5	-2.9	0.7	1.8	1.7	1.2	-0.1	-0.5
Miserableness	1.9	3.2	4.3	-1.7	1.1	1.9	2.0	2.1	1.8	1.8
Medication: Paracetamol	1.9	2.9	6.1	-2.5	1.0	2.1	1.9	1.8	0.6	1.1
LDL Cholesterol	1.8	2.8	6.1	-2.5	0.9	1.6	1.9	0.2	2.4	-0.9
Medication: Amlodipine	1.8	2.5	4.0	1.0	-0.1	-1.9	-1.8	-1.9	-2.0	-1.3
Breast cancer (self-reported)	1.8	2.2	5.8	-0.5	0.3	1.4	1.4	2.4	1.5	1.7
Mean Putamen Volume	1.7	1.9	3.2	-1.8	0.6	1.6	1.5	1.6	1.4	0.9
Ever used hormone-replacement therapy (HRT)	1.7	2.2	6.3	-1.7	0.3	-1.0	-0.6	-2.1	-0.5	-2.5
Chronic bronchitis/emphysema (father)	1.7	2.0	3.8	0.6	-0.9	-2.0	-1.9	-1.1	-1.8	-1.1
Friendships satisfaction	1.7	2.1	4.2	-0.1	1.6	1.2	1.0	2.1	1.1	2.0
Angina	1.6	2.1	4.5	0.8	-1.7	-1.0	-0.9	-1.7	-1.2	-2.1
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.6	2.1	0.9	-0.7	-0.8	-2.4	0.5	1.4
Medication for cholesterol	1.5	2.2	5.1	1.5	-2.2	-1.8	-1.6	-1.0	-1.0	-0.5
Mouth/teeth dental problems: Dentures	1.4	2.4	4.2	1.3	-1.0	-1.3	-1.4	-1.4	-2.0	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.6	0.0	-1.2	-1.5	-1.5	-0.6	-1.4	-1.9
Medication: Aspirin	1.4	1.9	5.3	0.4	-1.1	-1.2	-1.1	-1.5	-1.3	-2.3
Medication: Bendroflumethiazide	1.4	2.1	4.0	1.5	-0.6	-1.6	-1.7	-2.0	-1.1	-1.1
Blood White Count	1.3	9.6	39.3	-1.8	-4.1	1.1	-0.0	0.7	-2.4	-6.3
Allergy or Eczema	1.3	3.5	10.7	3.3	-0.7	-1.3	-1.6	-2.6	-0.9	1.2
Hypothyroidism (self reported)	1.3	3.1	7.8	-0.0	-1.9	-1.4	-1.4	-2.8	-1.6	-1.9
Supplements: Zinc	1.3	1.4	5.3	-2.3	-0.8	-0.7	-0.3	-0.6	0.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	2.5	-0.9	1.6	1.6	1.4	0.7	1.3	1.2
Prospective memory result	1.3	1.7	5.0	0.8	0.2	-1.3	-1.3	-2.2	-1.1	-1.1
Qualifications: College or University degree	1.3	4.2	8.7	0.8	-0.8	-2.4	-2.4	-2.9	-2.0	-2.0
Medication: Aspirin	1.3	1.7	4.6	0.4	-1.0	-1.1	-1.1	-1.4	-1.3	-2.1
Osteoarthritis (self-reported)	1.3	1.6	6.7	-0.9	2.6	0.7	0.9	0.3	1.5	0.5
Average weekly champagne plus white wine intake	1.3	1.8	6.7	-2.6	-0.8	-1.1	-0.6	0.3	-1.1	-1.5
Financial situation satisfaction	1.3	1.6	4.5	-0.5	0.5	2.1	1.8	1.3	1.0	0.4
Age started oral contraceptive pill	1.3	1.7	3.8	-1.4	1.9	0.9	1.2	0.2	1.4	1.3
Hayfever, allergic rhinitis or eczema	1.2	2.5	7.9	2.8	-0.1	-1.1	-1.2	-2.2	-0.2	1.5
Angina (self-reported)	1.2	1.5	4.0	0.6	-1.6	-0.7	-0.6	-1.4	-1.0	-2.0
Family relationship satisfaction	1.2	1.5	4.3	-0.2	1.1	0.9	0.9	1.6	0.9	2.1
Average weekly beer plus cider intake	1.2	1.8	3.9	2.0	-2.0	-0.6	-0.8	-1.0	-1.6	-0.7
Supplements: Calcium	1.2	1.3	3.4	-1.8	0.7	1.1	1.4	0.5	1.3	-0.1
Schizophrenia vs Biploar Disorder	1.1	1.5	4.0	-1.5	1.4	0.6	0.9	-0.9	2.0	0.5
Chronotype (morning person)	1.1	2.5	6.5	0.1	-2.5	-0.5	-0.8	-1.4	-1.7	-2.4
Financial difficulties in last 2 years	1.1	1.5	4.3	-1.2	0.6	1.3	1.4	2.1	0.8	0.2
Chronic bronchitis/emphysema (mother)	1.1	1.2	4.8	2.2	0.4	-0.6	-0.6	-1.0	-0.5	1.3
Medication: Omeprazole	1.1	1.3	2.8	-0.1	-1.0	-1.0	-1.1	-1.1	-1.3	-1.7
Heart disease (mother)	1.1	1.3	2.2	0.2	1.0	1.5	1.3	1.0	1.3	1.2
Medication: Atorvastatin	1.1	1.4	2.4	-0.9	1.5	1.4	1.6	0.9	1.1	-0.2
Ever depressed for a whole week	1.1	1.4	2.5	0.5	1.1	1.3	1.3	0.6	1.6	1.5
Ulcerative Colitis (UC)	1.0	1.9	10.0	0.4	-3.2	0.3	0.3	1.6	0.5	-0.6
Rheumatoid Arthritis	1.0	1.4	3.6	-0.3	1.9	-0.5	0.2	-1.2	1.4	1.5
Triglycerides	1.0	1.6	4.1	2.0	-1.2	-1.0	-1.0	-1.4	-0.9	-0.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.6	-1.6	-1.9	-0.2	0.2	0.6	0.8	-0.7
Hearing difficulty/problems with background noise	1.0	1.5	7.4	0.4	-2.7	-1.4	-0.9	0.4	-0.4	-0.3
Hip circumference	1.0	4.4	9.7	-0.9	1.9	1.4	1.7	3.1	2.3	2.6
Migraine (self-reported)	1.0	1.3	1.9	0.0	-1.4	-1.3	-1.3	-1.3	-0.7	-1.2
Illnesses of father: Heart disease	1.0	1.3	2.9	-1.7	0.2	1.6	1.5	-0.7	1.0	-0.5
Back pain experienced in last month	1.0	1.5	4.2	-0.1	1.2	1.2	1.1	2.0	0.9	1.1
Hearing aid user	1.0	1.1	3.7	-1.9	0.3	0.1	0.8	1.0	1.4	-0.6
High cholesterol (Self-reported)	1.0	1.8	4.3	-2.1	0.3	1.6	1.7	-0.3	1.2	-0.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.6	0.0	-1.6	-0.9	-1.0	-0.5	-1.3	-1.3
Schizophrenia (2018)	0.9	1.9	6.0	-2.5	1.6	1.2	1.2	0.7	0.8	0.7
Breast Cancer	0.9	2.2	7.1	1.7	-0.3	-1.2	-1.2	-2.7	-0.6	-1.4
Ulcerative Colitis	0.9	1.3	7.0	0.3	-2.6	-0.8	-0.5	0.7	-0.2	-0.9
Blood Platelet Count	0.9	11.0	17.3	-3.4	3.9	2.0	3.3	2.5	4.2	3.5
Type 2 Diabetes (T2D) (2018)	0.9	1.7	7.3	-1.1	-1.1	0.7	0.8	2.7	-0.0	-0.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.4	-0.6	0.2	1.3	1.6	0.4	1.8	0.2
Happiness	0.9	1.1	2.9	-0.4	0.1	0.7	0.8	1.7	0.8	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.1	0.4	0.2	0.8	1.1	1.1	0.9	1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	5.2	-2.3	0.4	0.4	0.7	1.3	0.2	-0.0
Birth weight	0.9	1.9	4.0	-0.6	1.0	1.7	1.5	1.5	0.7	2.0
Number of children fathered	0.9	1.1	3.2	1.5	-0.4	-0.4	-0.8	-1.8	-0.8	-0.5
Wears glasses or contact lenses	0.9	1.1	1.8	-1.0	-1.3	-1.2	-1.0	-0.3	-0.6	-1.3
Mother’s age at death	0.9	1.1	2.7	1.6	-0.5	-1.5	-1.4	-0.7	-0.1	0.8
Illnesses of father: High blood pressure	0.9	1.1	2.0	-0.7	0.3	1.1	1.3	0.3	1.4	1.4
Prostate Cancer	0.8	1.1	2.2	-0.4	1.5	0.9	1.1	0.8	1.0	1.1
Sensitivity / hurt feelings	0.8	1.4	4.4	0.7	1.4	0.9	0.8	0.4	1.1	2.1
Fed-up feelings	0.8	1.5	3.0	-0.8	1.7	0.9	0.9	1.2	1.0	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.0	-1.3	-0.4	0.7	0.8	1.4	1.3	0.7
Qualifications: CSEs or equivalent	0.8	1.0	3.5	-0.2	0.8	0.2	0.4	1.5	0.5	1.9
Multivitamins +/- minerals	0.8	1.1	2.6	0.1	-0.3	-1.6	-1.6	0.3	-1.5	0.0
Medication: Simvastatin	0.8	1.2	4.7	-1.1	-0.5	0.1	-0.2	-1.2	-0.9	-2.2
Father’s age at death	0.8	1.0	2.5	1.6	-0.6	-1.1	-1.1	-0.8	-1.0	0.5
Number of live births	0.8	1.1	4.6	-1.4	-0.5	0.7	0.6	-0.5	0.1	-2.2
Pulse rate	0.8	1.3	2.5	-1.6	1.4	1.2	1.2	0.9	0.9	0.2
Standing height	0.8	8.2	28.4	2.8	0.8	1.3	1.4	3.8	1.6	5.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	4.2	-0.4	-0.8	-1.3	-1.2	-2.0	-0.9	-1.2
Number of full sisters	0.8	1.0	2.2	-1.5	-0.6	-0.6	-0.5	-0.4	-1.5	-1.3
Loneliness, isolation	0.8	1.2	3.3	-1.2	0.9	0.4	0.4	1.8	0.6	1.4
Diabetes diagnosed by doctor	0.8	1.4	3.1	-0.6	-1.6	-0.5	-0.5	1.5	-0.8	-1.7
Eye problems/disorders: Glaucoma	0.8	0.9	3.1	-1.8	-1.2	-0.8	-0.4	0.2	-0.0	-1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.0	0.6	1.0	-1.7	-1.5	-0.8	-0.5	0.5
Alcohol drinker status: Never	0.8	0.9	5.4	0.5	-2.3	-0.5	-0.5	-0.1	-0.5	-0.1
Irritability	0.8	1.4	3.2	-1.8	0.7	1.2	1.3	1.3	1.0	-0.4
Depressed Affect (Nagel 2018)	0.7	1.4	2.2	-1.2	1.5	0.9	0.9	1.4	1.0	1.2
Number of treatments/medications taken	0.7	1.3	4.2	-0.2	-0.6	-0.9	-0.9	-1.6	-0.7	-2.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.1	-1.4	-1.2	0.6	0.7	0.8	0.5	-0.1
Diabetes (father)	0.7	0.8	4.2	2.0	-0.2	0.3	0.2	-0.0	-0.2	1.2
Serious illness, injury or assault to yourself	0.7	0.8	4.3	-2.1	0.5	-0.8	-0.5	-0.1	0.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	0.7	0.6	0.9	0.7	1.1	0.6	1.3
Medication: Levothyroxine sodium	0.7	1.2	2.6	-1.2	-1.6	-0.1	-0.2	-1.2	-0.7	-1.5
Allergy	0.7	1.6	4.5	-2.1	0.7	1.0	1.1	1.9	0.6	-0.3
Diabetes (self-reported)	0.7	1.1	3.8	-0.2	-1.2	-0.4	-0.4	1.1	-0.9	-1.9
Neuroticism score	0.7	1.5	3.9	0.4	0.9	1.2	1.2	1.3	1.1	2.0
Trunk fat-free mass	0.7	4.3	9.5	-0.0	1.9	1.2	1.5	3.1	2.0	3.0
Time employed in main current job	0.7	0.8	1.4	-0.8	1.2	0.9	1.0	0.1	1.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.1	-2.0	-0.2	0.7	0.6	1.6	-0.2	-0.1
Trunk predicted mass	0.7	3.9	9.5	-0.1	1.8	1.0	1.4	3.1	1.9	2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.0	0.8	1.0	0.9	0.8	0.6	1.2	1.7
Gout (self-reported)	0.7	1.0	2.0	-0.1	-0.6	-1.1	-1.1	-1.1	-1.0	-1.4
Comparative body size at age 10	0.7	1.9	6.7	0.7	1.7	0.9	0.9	0.7	1.1	2.6
Shortness of breath walking on level ground	0.7	0.8	4.2	-0.6	-0.3	-0.1	-0.2	0.4	-0.8	-2.0
Neck or shoulder pain in last month	0.7	1.0	2.1	-0.0	-0.7	-1.2	-1.5	-0.9	-1.2	-0.7
Overall health rating	0.7	1.4	2.2	-1.4	1.4	1.3	1.2	1.5	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	1.0	0.5	0.7	0.9	0.9	0.6	1.5
Neuroticism (Nagel 2018)	0.6	1.3	3.5	0.3	1.9	0.8	0.8	0.7	0.8	1.9
Worry (Nagel 2018)	0.6	1.2	2.8	1.5	1.7	0.3	0.2	-0.1	0.9	1.6
Lupus	0.6	1.0	3.2	-0.3	-0.1	-1.5	-1.0	-1.8	-0.3	-0.0
Schizophrenia (2014)	0.6	1.2	6.3	-2.5	0.7	0.8	0.9	0.3	0.4	-0.2
Systolic blood pressure, automated reading	0.6	1.8	3.8	-0.8	1.6	2.0	1.6	1.5	0.7	0.6
Current tobacco smoking	0.6	0.9	2.8	1.0	-1.7	-0.1	-0.3	-1.0	-1.2	0.1
Relative age voice broke	0.6	0.9	1.6	-0.0	1.1	1.2	1.1	0.3	1.3	0.8
Worrier / anxious feelings	0.6	1.2	4.9	2.2	1.1	0.2	0.0	-0.5	0.5	1.3
Length of working week for main job	0.6	0.6	1.2	-0.9	0.5	0.8	1.1	0.2	0.9	0.8
Hair/balding pattern: Pattern 4	0.6	1.3	2.7	-0.5	1.1	1.6	1.4	0.7	1.1	1.2
Blood clot in the leg (DVT)	0.6	0.8	2.9	-1.7	-0.7	0.6	0.7	0.5	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.0	1.3	-1.4	-0.3	-0.4	0.6	0.2	0.9
High blood pressure (siblings)	0.6	0.9	2.7	0.5	1.6	0.8	0.7	-0.0	0.9	1.3
Exposure to tobacco smoke outside home	0.6	0.8	1.9	-0.6	0.0	1.4	1.3	0.9	0.4	0.7
Worry too long after embarrassment	0.6	1.0	4.5	1.3	0.3	0.4	0.4	0.5	0.4	2.1
Age at first live birth	0.6	1.1	4.6	2.1	-0.9	-0.3	-0.8	-0.7	-0.9	0.5
Pulse wave peak to peak time	0.6	0.8	2.0	-0.4	0.4	0.5	0.8	0.7	1.4	1.2
Eye problems/disorders: None of the above	0.6	0.7	2.0	0.2	1.2	0.7	0.4	0.7	0.3	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.7	-1.4	1.6	0.4	0.0	0.6	-0.3	0.5
Whole body fat-free mass	0.6	3.4	8.1	0.1	1.4	1.0	1.3	2.9	1.7	2.8
Mineral and other dietary supplements	0.6	0.8	2.6	-0.2	-0.3	1.6	1.3	0.5	1.0	0.1
Whole body water mass	0.6	3.2	7.7	0.0	1.5	1.0	1.3	2.8	1.7	2.7
Number of self-reported non-cancer illnesses	0.6	1.1	2.9	-0.0	-0.7	-0.9	-0.8	-1.4	-0.8	-1.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-0.8	-0.7	-1.1	-0.9	-0.9	-1.0	-0.4
Ever smoked	0.6	1.1	2.2	0.8	-1.0	-1.1	-1.1	-0.7	-1.5	-0.8
Basal metabolic rate	0.6	3.3	8.2	0.1	1.3	1.1	1.3	2.9	1.7	2.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.4	-1.6	-0.6	0.9	0.9	0.6	-0.4	-0.6
Heart disease (siblings)	0.6	0.8	2.5	-1.6	-0.4	0.3	0.5	-0.2	-0.0	-1.5
HbA1C	0.5	0.5	3.1	-1.8	-0.4	0.4	0.4	0.1	0.1	-0.1
HDL Cholesterol	0.5	0.8	1.9	-0.4	0.8	1.0	0.7	1.4	0.3	1.1
Height	0.5	10.0	35.0	3.3	1.3	-0.4	0.5	3.8	2.8	5.9
Lung FVC	0.5	2.5	10.4	-1.1	3.2	0.1	0.6	0.5	1.0	2.0
Tanning	0.5	6.1	13.8	0.8	-2.0	-2.8	-3.0	-1.7	-3.7	-2.1
Relative age of first facial hair	0.5	1.1	2.3	0.8	-0.7	-1.1	-1.2	-1.5	-1.0	-0.8
Leg fat-free mass (left)	0.5	2.8	6.8	0.1	0.9	1.2	1.4	2.6	1.5	2.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.0	-1.4	0.7	-0.8	-0.5	0.6	-0.5	-0.5
Leg predicted mass (left)	0.5	2.8	6.6	0.1	0.9	1.2	1.4	2.6	1.6	2.5
Past tobacco smoking	0.5	0.9	2.4	0.1	0.7	0.8	1.0	0.4	1.6	1.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.4	0.8	-0.7	-1.2	-1.1	-0.5	-0.7	-0.6
Medication: Ramipril	0.5	0.6	1.3	0.4	0.7	1.1	1.0	0.2	1.1	0.5
Falls in the last year	0.5	0.7	1.6	0.6	1.3	0.9	0.8	0.4	0.4	1.1
Medication: Lansoprazole	0.5	0.5	2.0	-1.4	0.8	0.3	0.6	-0.0	0.5	-0.5
Illnesses of mother	0.5	0.6	1.6	-0.5	-0.6	1.2	1.3	0.6	0.5	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	0.7	-0.3	-0.5	-0.8	-0.4	-1.3	-0.9
Loud music exposure frequency	0.5	0.6	1.6	-0.8	-0.6	-1.3	-1.0	-0.4	-0.4	-0.4
Medication: Paracetamol	0.5	0.8	2.8	-1.7	-0.2	1.1	1.0	0.8	0.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-0.9	1.1	0.9	0.8	0.4	1.0	-0.0
Wheeze or whistling in the chest in last year	0.5	0.9	4.8	2.2	-0.4	0.2	-0.0	-0.1	0.1	1.2
Had major operations	0.5	0.5	1.8	-0.4	0.3	1.0	0.7	-0.3	0.3	1.3
Illnesses of siblings: Diabetes	0.5	0.6	1.4	1.2	-1.0	0.8	0.8	-0.1	0.9	0.1
Leg fat-free mass (right)	0.5	2.9	6.9	0.1	0.9	1.1	1.4	2.5	1.7	2.6
Mood swings	0.5	0.9	1.4	-1.2	1.0	1.0	1.0	1.1	0.7	0.5
Leg predicted mass (right)	0.5	2.9	6.9	0.1	1.0	1.1	1.4	2.5	1.7	2.6
Commuting to job workplace: Public transport	0.5	0.5	2.2	1.1	0.7	-0.1	-0.2	0.1	0.1	1.5
Alcohol drinker status: Previous	0.5	0.6	1.7	-1.2	-1.3	-0.1	0.1	-0.6	-0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.4	1.4	2.9	0.3	-1.2	-1.4	-1.7	-0.2	-1.7	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	1.7	0.6	-1.3	0.2	-0.0	-0.6	-0.1	-0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	-0.6	-1.4	-0.1	0.1	-0.4	0.0	-1.3
Neuroticism (2016)	0.4	0.6	2.2	0.1	1.5	0.0	0.3	0.2	0.6	1.2
Smoking Status	0.4	1.0	1.6	0.9	-1.3	-0.7	-0.8	-1.2	-1.3	-0.4
Average weekly spirits intake	0.4	0.5	2.0	-0.6	1.4	-0.2	-0.0	0.1	0.6	0.8
Severe depression (siblings)	0.4	0.5	1.7	0.4	-1.3	0.0	-0.3	0.0	-1.2	-0.4
Hand grip strength (right)	0.4	1.0	3.0	-0.5	0.7	0.7	0.8	1.7	0.8	1.2
Maternal smoking around birth	0.4	0.6	1.7	-0.0	-1.1	-0.5	-0.7	-0.0	-1.3	-0.9
Stomach or abdominal pain in last month	0.4	0.5	1.4	-0.6	0.8	-0.0	-0.1	1.2	0.1	0.8
Sitting height	0.4	3.2	11.5	0.2	0.4	0.0	0.4	3.1	0.9	3.4
Impedance of leg (left)	0.4	1.7	5.2	2.3	-1.2	-1.2	-1.4	-0.8	-1.2	0.0
Nervous feelings	0.4	0.7	2.6	-0.2	1.6	0.2	0.3	0.8	0.9	0.9
Qualifications: None of the above	0.4	0.8	1.7	-1.3	-0.6	1.0	1.1	-0.3	0.8	-0.5
Pain all over the body in last month	0.4	0.4	1.1	-0.4	0.8	0.2	0.3	-1.0	0.8	0.1
Illnesses of siblings	0.4	0.5	1.0	0.7	-0.7	-0.9	-1.0	-0.2	-0.7	-0.1
Weight	0.4	2.1	6.6	0.3	1.0	0.8	0.9	2.6	1.2	2.0
Impedance of arm (right)	0.4	1.7	6.8	2.6	-1.3	0.6	0.3	-0.1	-0.2	1.8
Depression (self-reported)	0.4	0.5	1.3	-0.4	0.2	1.1	1.0	0.5	0.5	0.7
Exposure to tobacco smoke at home	0.4	0.5	1.1	-1.1	-0.7	0.6	0.5	0.7	-0.4	-0.6
Breastfed as a baby	0.4	0.5	0.9	-0.8	0.8	0.9	0.9	-0.3	0.4	0.4
Tense / ‘highly strung’	0.4	0.6	3.3	0.7	0.7	0.3	0.2	0.5	0.0	1.8
Pulse wave reflection index	0.4	0.5	1.7	1.3	-0.1	-0.4	-0.5	-0.8	-1.0	0.2
Glaucoma (self-reported)	0.4	0.5	1.4	-1.1	-1.2	-0.4	-0.2	0.9	-0.1	0.1
Number of full brothers	0.4	0.4	2.6	-1.6	-0.3	0.2	0.2	0.3	-0.4	-0.3
Health satisfaction	0.4	0.6	2.0	-1.4	-0.9	0.0	0.1	0.4	-0.5	-0.8
Mean time to correctly identify matches	0.4	0.8	2.3	-0.6	-1.5	0.5	0.2	-0.2	-1.1	-1.1
Alcohol intake frequency.	0.4	0.8	2.5	-0.3	-1.6	-0.3	-0.2	-0.8	-0.1	-1.5
Comparative height size at age 10	0.4	2.3	8.3	1.2	0.6	-0.0	0.3	2.3	1.0	2.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.3	0.7	1.1	0.4	-0.0	-1.0	0.0	-0.2
Supplements: Vitamin C	0.4	0.5	1.2	-0.9	-0.6	-0.4	-0.3	-0.5	-0.8	-1.1
Long-standing illness, disability or infirmity	0.4	0.6	2.2	-0.7	-1.0	-0.4	-0.1	0.3	-0.2	-1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	0.0	0.6	-1.0	-0.8	1.3	0.1	0.3
Medication: Blood pressure	0.4	0.7	1.6	0.0	0.6	1.2	1.1	1.3	0.4	0.1
Medication: Lisinopril	0.4	0.5	1.9	0.0	-0.2	-1.4	-1.1	-0.4	-0.3	-0.4
Risk taking	0.4	0.5	1.1	0.6	-0.4	-1.1	-0.8	-0.9	-0.7	-0.3
Pain experienced in last month	0.4	0.7	2.7	0.2	-1.7	-0.2	0.0	-0.1	-0.2	-1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	0.4	-1.3	-0.3	-0.5	-0.1	-0.6	-1.0
Pack years of smoking	0.4	0.6	2.3	0.9	-1.0	-0.2	-0.4	-0.3	-1.5	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.3	-0.8	0.0	-0.2	-1.1	0.6	-0.7
Reaction Time	0.3	0.6	2.9	-0.4	-1.7	0.4	0.4	0.1	-1.0	-0.1
Ovarian Cancer	0.3	0.5	1.5	-0.4	-0.1	-1.2	-0.8	-0.4	-0.2	-0.9
Age at First Birth	0.3	0.4	1.1	1.1	0.7	-0.7	-0.6	-0.1	0.4	0.2
Fasting Glucose	0.3	0.4	2.1	0.4	1.4	-0.2	-0.4	-0.3	-0.4	0.3
Blood Red Count	0.3	2.5	7.5	-2.7	-1.2	0.5	1.0	1.9	0.6	-1.9
Respiratory disease	0.3	0.7	3.2	1.8	-0.7	0.4	0.3	-0.3	0.5	1.0
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	-0.3	-0.7	-0.9	-0.6	0.2	-0.6	-0.6
Medication for hormone replacement therapy	0.3	0.4	1.1	-0.9	-0.3	-0.1	-0.4	-0.3	-1.0	-0.6
Diabetes (mother)	0.3	0.3	1.0	-1.0	-0.0	0.5	0.5	0.1	0.9	-0.3
Age when periods started (menarche)	0.3	0.6	1.3	0.5	-0.8	-0.9	-0.9	0.2	-1.1	-0.8
High blood pressure (mother)	0.3	0.4	0.7	-0.7	-0.2	-0.5	-0.8	0.7	-0.8	-0.2
Waist circumference	0.3	1.1	4.3	-0.3	0.9	0.7	0.8	2.1	0.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	-1.0	0.2	0.3	0.3	1.0	0.8	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.1	0.4	0.9	0.7	0.4	0.3	1.0
Mouth/teeth dental problems	0.3	0.5	1.4	0.5	0.2	0.8	0.9	-0.4	1.2	0.0
Fluid intelligence score	0.3	0.7	2.0	0.0	-0.4	-0.9	-1.0	-0.8	-1.4	-0.4
Noisy workplace	0.3	0.4	1.8	0.1	-0.9	-0.1	-0.3	1.3	-0.4	0.2
Asthma	0.3	0.7	2.2	1.5	-0.8	-0.9	-0.8	-0.6	-0.0	0.1
Impedance of arm (left)	0.3	1.6	4.4	2.1	-0.8	1.0	0.8	0.3	0.3	2.1
Headache pain in last month	0.3	0.5	1.5	-0.3	-0.2	-1.2	-1.0	-0.9	-0.0	-0.6
Arm fat-free mass (right)	0.3	1.5	4.7	0.2	1.3	0.1	0.4	2.2	0.9	1.8
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.2	-0.9	-0.2	-0.2	0.8	-0.7	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.0	0.1	0.7	0.7	0.4	0.7	0.9
Smoking status: Previous	0.3	0.4	1.2	0.3	-0.3	-0.4	-0.7	-0.1	-1.1	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-0.8	-1.0	-0.1	-0.1	-0.5	-0.2	-0.7
Ever had bowel cancer screening	0.3	0.4	0.9	-0.5	0.6	-0.0	-0.3	-0.6	-0.9	-1.0
Commuting to job workplace: Walk	0.3	0.4	1.0	-0.9	0.6	0.4	0.4	-0.2	0.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	-0.5	-0.6	-0.6	-0.6	1.2	-0.1	0.7
Asthma (self-reported)	0.3	0.6	2.0	1.4	-0.7	-0.9	-0.8	-0.7	-0.0	0.3
Arm fat-free mass (left)	0.3	1.4	4.4	0.1	1.1	0.2	0.5	2.1	1.1	1.7
Fractured/broken bones in last 5 years	0.3	0.4	2.3	-0.5	1.5	-0.2	-0.3	0.1	-0.0	-0.3
Diastolic blood pressure, automated reading	0.3	1.1	1.8	-0.2	1.3	1.2	1.2	0.7	1.2	0.8
Commuting to job workplace: Cycle	0.3	0.4	1.3	1.2	-0.1	0.1	-0.0	-1.1	0.0	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.9	-0.7	0.2	0.5	0.7	0.8	0.8	2.0
Impedance of whole body	0.3	1.5	6.4	2.5	-1.3	-0.1	-0.4	-0.5	-0.8	1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-1.0	-0.5	-0.1	-0.2	0.5	-1.2	-0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.6	-0.6	0.2	0.2	-0.7	0.5	-0.2
Blood Eosinophil Count	0.2	1.9	4.2	2.1	-0.3	-1.5	-1.8	-0.5	-1.7	0.0
Heel T-Score	0.2	1.2	2.0	0.9	-1.1	-1.0	-1.1	-1.4	-1.4	-0.1
BMI	0.2	1.2	3.8	-1.9	0.4	0.7	0.6	1.8	0.5	-0.8
Waist Hip Ratio (WHR)	0.2	0.9	3.3	0.8	-0.8	-0.0	-0.3	-0.7	-1.0	-1.8
Neuroticism	0.2	0.4	1.5	0.6	0.9	-0.0	-0.0	-0.0	0.4	1.2
Hearing difficulty/problems: Yes	0.2	0.4	1.3	-0.0	-0.3	-0.2	0.1	1.2	0.6	0.8
Medication: Metformin	0.2	0.3	1.1	-0.2	0.3	-0.2	-0.2	0.9	-0.4	-1.1
Pack years adult smoking proportion	0.2	0.2	0.6	0.4	-0.4	0.6	0.4	0.4	-0.8	0.1
Impedance of leg (right)	0.2	1.0	3.3	1.8	-1.2	-0.7	-1.0	-0.2	-1.1	0.1
Townsend deprivation index at recruitment	0.2	0.2	0.9	0.6	-0.9	0.1	-0.0	-0.5	-0.4	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	0.5	-0.2	-0.0	-0.2	-1.2	-0.4	0.8
Number of incorrect matches in round	0.2	0.3	0.5	0.5	-0.3	-0.4	-0.7	-0.6	-0.7	-0.2
Alcohol usually taken with meals	0.2	0.4	1.1	-1.1	0.6	0.1	0.1	1.0	-0.2	0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.8	0.2	0.5	0.4	-0.4	0.6	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.9	-0.2	-0.4	-0.4	0.3	0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	-0.2	-0.2	0.3	0.4	-0.8	0.5	-0.3
Medication: Allopurinol	0.2	0.3	0.7	-0.5	-0.3	-0.1	-0.1	-0.9	-0.3	-0.8
Arm predicted mass (right)	0.2	1.2	4.5	-0.0	1.0	0.1	0.3	2.1	0.8	1.4
Age at last live birth	0.2	0.2	0.6	0.7	-0.6	0.8	0.4	-0.4	-0.1	-0.0
Hypertension (Self-reported)	0.2	0.5	1.9	0.3	0.8	-0.5	-0.6	-0.4	-0.6	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.7	-0.2	-0.0	-0.3	0.7	-0.6	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.7	0.4	0.7	0.6	-0.0	0.2	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.4	0.6	0.4	0.6	0.4	-0.3	0.4	0.3
Smoking status: Current	0.2	0.3	0.9	0.3	-1.0	0.3	0.2	-0.3	-0.6	0.6
Arm fat mass (left)	0.2	0.6	2.4	-0.0	0.4	0.6	0.6	1.6	0.7	0.9
Guilty feelings	0.2	0.4	0.9	0.7	0.8	0.3	0.1	-0.5	-0.2	0.9
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	0.3	0.6	0.6	-0.1	0.3	0.6
Myopia	0.2	0.3	0.7	-0.9	0.3	0.5	0.4	-0.8	-0.4	-0.3
Arm predicted mass (left)	0.2	1.2	4.1	0.2	1.0	-0.0	0.3	2.0	0.9	1.6
Depression (Nagel 2018)	0.1	0.2	0.6	-0.8	-0.6	-0.2	-0.2	-0.2	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.1	0.2	-0.2	-0.4	0.4	-0.5	0.7
Coronary Artery Disease (CAD)	0.1	0.2	1.1	-1.1	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.7	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.1	0.6	1.6	1.2	-0.3	0.9	0.5	-0.7	-0.9	-0.3
Cardiovascular Disease	0.1	0.2	0.6	-0.1	0.5	0.8	0.6	-0.2	0.1	-0.3
Hand grip strength (left)	0.1	0.2	0.6	0.5	0.1	0.2	0.3	0.8	0.4	0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.6	-0.5	0.1	0.0	0.3	0.3	0.1
Vitamin and mineral supplements	0.1	0.1	0.3	0.4	-0.1	0.3	0.3	-0.4	0.2	-0.6
Trunk fat percentage	0.1	0.3	0.9	0.9	-0.5	-0.0	-0.2	0.8	-0.4	0.1
High blood pressure	0.1	0.3	1.8	0.1	0.6	0.0	-0.2	0.1	-0.4	-1.3
Body mass index (BMI)	0.1	0.4	1.0	-1.0	0.6	0.3	0.3	0.9	0.5	-0.5
Trunk fat mass	0.1	0.5	2.3	0.9	-0.1	0.3	0.2	1.5	0.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	0.2	-0.0	0.3	0.0	-1.0	-0.5	0.8
Arm fat percentage (right)	0.1	0.2	1.1	0.1	-0.1	0.5	0.4	1.0	0.3	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	1.0	0.3	0.4	-0.2	-0.2	-1.0	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	0.9	-0.2	-0.1	-0.2	0.6	0.3	0.9
Lung cancer (father)	0.1	0.1	0.6	0.3	0.2	-0.1	-0.2	-0.8	0.0	-0.2
Arm fat mass (right)	0.1	0.4	2.1	0.0	0.2	0.4	0.4	1.4	0.6	0.6
Body fat percentage	0.1	0.3	0.6	0.7	-0.8	-0.3	-0.5	0.6	-0.6	-0.5
Leg fat percentage (right)	0.1	0.4	1.1	-0.1	-0.7	-0.2	-0.5	0.8	-0.5	-1.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.7	0.6	-0.1	-0.1	0.3	0.4	0.5
Whole body fat mass	0.1	0.4	1.8	0.7	-0.4	-0.1	-0.2	1.3	-0.1	0.3
Leg fat mass (right)	0.1	0.3	1.7	0.0	-0.2	0.1	-0.0	1.3	0.1	-0.0
Chest pain or discomfort	0.1	0.1	0.6	-0.8	0.0	-0.2	-0.1	0.5	-0.2	-0.1
Arm fat percentage (left)	0.1	0.3	1.4	-0.0	0.1	0.6	0.5	1.2	0.4	0.2
Average weekly red wine intake	0.1	0.1	0.3	0.5	0.3	-0.1	-0.4	-0.2	-0.4	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.9	-0.1	0.5	0.2	0.2	0.9	-0.0	0.6
Leg fat percentage (left)	0.1	0.4	1.1	0.3	-0.8	-0.5	-0.7	0.4	-0.6	-1.0
Number of operations (self-reported)	0.1	0.2	0.5	0.4	0.3	-0.0	-0.0	0.7	-0.0	0.7
Leg fat mass (left)	0.1	0.2	1.3	0.3	-0.2	0.0	-0.1	1.1	0.1	-0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	3.0	1.0	-0.3	-0.5	-0.9	-0.2	-1.7	-0.1

Hub : Genes

S1PR5

Models

Trait associations