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chr10:103,550,604-105,910,221

Best TWAS P=9.88e-14 · Best GWAS P=2.92e-13 conditioned to 0.655

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-4.0	-5.7	1.2e-08	0.61	0.25	0.32	FALSE
2	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	5.4	6.7	2.0e-11	-0.76	0.06	0.82	FALSE
3	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	-5.8	6.3	3.0e-10	-0.78	0.08	0.79	FALSE
4	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	-5.8	-5.6	2.0e-08	0.73	0.64	0.26	FALSE
5	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	-5.4	-5.9	4.3e-09	0.58	0.08	0.81	FALSE
6	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	-5.4	-5.7	1.1e-08	0.70	0.07	0.78	FALSE
7	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	-5.4	-6.0	1.5e-09	0.77	0.05	0.67	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	-5.3	-5.4	8.1e-08	0.63	0.22	0.12	FALSE
9	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	-5.4	-5.8	5.9e-09	0.60	0.13	0.29	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-6.6	-7.1	1.4e-12	0.56	0.07	0.19	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	3.6	-5.2	2.1e-07	0.50	0.55	0.04	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	-5.5	-5.5	3.7e-08	0.50	0.20	0.19	FALSE
13	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	1.1	5.5	4.4e-08	-0.58	0.04	0.53	FALSE
14	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	-5.3	-5.5	3.2e-08	0.66	0.72	0.09	FALSE
15	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	-5.3	-5.4	6.8e-08	0.64	0.50	0.22	FALSE
16	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-6.6	6.6	3.1e-11	-0.37	0.26	0.64	FALSE
17	METSIM	Adipose	CALHM2	0.04	0.01	enet	27	0.03	4.8e-05	1.7	-5.9	4.0e-09	0.21	0.40	0.06	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-6.7	-6.7	2.2e-11	0.38	0.18	0.82	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	-5.4	-6.1	1.1e-09	0.64	1.00	0.00	FALSE
20	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-6.6	-5.8	7.0e-09	0.18	0.15	0.85	FALSE
21	YFS	Blood	PCGF6	0.02	0.01	blup	370	0.01	1.6e-04	3.5	-5.2	2.2e-07	0.44	0.90	0.01	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-6.6	7.4	9.9e-14	-0.78	0.21	0.78	TRUE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	-6.6	5.6	2.1e-08	-0.73	0.36	0.64	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	-6.6	6.6	3.9e-11	-0.83	0.10	0.88	FALSE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	-5.8	5.6	1.9e-08	-0.79	0.36	0.62	FALSE
26	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	-5.8	6.1	1.1e-09	-0.84	0.05	0.44	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	-6.6	6.2	6.2e-10	-0.83	0.31	0.69	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	-5.5	5.5	4.2e-08	-0.62	0.07	0.89	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	-5.8	5.8	6.3e-09	-0.77	0.06	0.34	FALSE