TWAS hub - PIGO

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.0980	0.0570	8.3e-03	0.065	NA	0.040	NA	0.030	2.7e-04	NA	3.6e-03	NA	1.1e-02
2	GTEx	Artery Aorta	0.1350	0.0510	3.9e-04	0.112	NA	0.066	NA	0.099	9.8e-07	NA	1.7e-04	NA	4.1e-06
3	GTEx	Artery Tibial	0.0547	0.0249	4.5e-03	-0.003	NA	-0.003	NA	-0.003	8.0e-01	NA	8.7e-01	NA	8.6e-01
4	GTEx	Brain Cerebellum	0.1450	0.0630	5.9e-03	0.024	NA	0.045	NA	0.046	6.7e-02	NA	1.9e-02	NA	1.7e-02
5	GTEx	Brain Hypothalamus	0.1710	0.0810	8.8e-03	0.020	NA	-0.013	NA	-0.008	1.1e-01	NA	9.6e-01	NA	5.4e-01
6	GTEx	Cells Transformed fibroblasts	0.0390	0.0200	7.9e-03	0.040	NA	0.033	NA	0.031	5.6e-04	NA	1.5e-03	NA	2.2e-03
7	GTEx	Lung	0.0580	0.0303	9.9e-03	-0.001	NA	-0.004	NA	-0.002	3.9e-01	NA	9.9e-01	NA	5.4e-01
8	GTEx	Nerve Tibial	0.0855	0.0407	1.5e-03	0.010	NA	-0.003	NA	0.002	6.2e-02	NA	7.1e-01	NA	2.1e-01
9	GTEx	Skin Sun Exposed Lower leg	0.1280	0.0520	1.7e-04	-0.003	NA	0.034	NA	0.005	6.9e-01	NA	7.7e-04	NA	1.2e-01
10	GTEx	Testis	0.2550	0.0670	1.8e-08	0.296	NA	0.261	NA	-0.003	1.3e-13	NA	6.0e-12	NA	4.9e-01
11	TCGA	Bladder Urothelial Carcinoma	0.0470	0.0270	6.9e-03	0.033	0.021	0.024	NA	0.035	8.6e-04	6.4e-03	4.0e-03	NA	6.1e-04
12	TCGA	Breast Invasive Carcinoma	0.0185	0.0122	5.0e-03	0.001	0.007	0.005	NA	0.000	2.3e-01	1.0e-02	3.0e-02	NA	3.9e-01
13	TCGA	Cervical Squamous Cell Carcinoma	0.1150	0.0670	3.1e-03	0.023	0.054	0.033	NA	0.027	2.5e-02	1.2e-03	9.3e-03	NA	1.7e-02
14	TCGA	Colon Adenocarcinoma	0.0890	0.0510	9.8e-04	0.027	0.051	0.046	NA	0.035	1.0e-02	6.5e-04	1.2e-03	NA	4.3e-03
15	TCGA	Kidney Renal Clear Cell Carcinoma	0.0221	0.0126	2.8e-03	0.003	0.016	0.003	NA	0.003	1.4e-01	5.5e-03	1.4e-01	NA	1.3e-01
16	TCGA	Brain Lower Grade Glioma	0.1041	0.0397	4.4e-08	0.074	0.069	0.067	NA	0.065	8.2e-09	2.6e-08	4.5e-08	NA	6.5e-08
17	TCGA	Prostate Adenocarcinoma	0.0588	0.0281	6.4e-05	0.035	0.039	0.045	NA	0.015	1.2e-04	5.6e-05	1.5e-05	NA	9.4e-03
18	TCGA	Testicular Germ Cell Tumors	0.2100	0.0800	1.1e-04	0.072	0.117	0.110	NA	0.106	1.6e-03	6.4e-05	1.1e-04	NA	1.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Time employed in main current job	7.0	8.1	14.4	-3.4	-2.4	-3.1	-1.7	-2.0	-3.3	-3.3	-3.3	-0.7	-2.8	-3.3	-2.7	-2.2	-2.4	-3.0	-3.2	-3.8	-2.9
Qualifications: NVQ or HND or HNC or equivalent	6.8	8.2	18.6	4.3	0.4	2.5	2.7	3.0	2.8	2.1	3.5	2.9	3.4	3.6	2.6	1.8	2.0	0.7	3.3	3.7	3.2
Verbal and Numeric Reasoning (VNR)	5.9	14.1	29.6	-5.4	-2.0	-3.4	-2.8	-2.5	-4.5	-3.5	-3.9	-3.6	-4.4	-4.7	-4.0	-2.7	-3.3	-1.8	-4.7	-4.5	-3.6
Schizophrenia (2018)	5.1	10.5	17.9	4.1	3.3	3.0	4.1	3.0	4.2	3.5	3.5	1.4	3.7	0.0	4.0	2.6	3.4	3.3	2.7	3.5	2.2
Multivitamins +/- minerals	4.3	5.5	8.7	2.9	1.4	2.2	0.9	2.5	2.6	2.8	2.4	2.1	2.6	2.8	2.2	2.2	2.6	1.5	2.3	2.8	2.4
Neck or shoulder pain in last month	4.3	6.1	10.9	2.1	2.7	2.4	2.2	2.1	3.0	2.8	2.8	2.2	1.7	2.7	3.1	1.5	2.4	3.0	1.8	3.3	1.4
Ever used hormone-replacement therapy (HRT)	3.5	4.5	10.1	1.7	2.0	2.4	3.2	2.8	2.8	2.4	1.5	1.3	2.3	1.8	2.2	2.3	2.5	1.4	1.7	1.1	1.5
Alcohol intake versus 10 years previously	3.5	5.2	10.9	-2.6	-1.3	-2.9	-2.3	-3.3	-2.7	-1.8	-2.3	-2.1	-2.8	-2.7	-2.0	-1.8	-2.2	-1.5	-2.1	-1.8	-1.7
Intelligence (Savage-Jansen 2018)	3.4	10.5	21.7	-4.7	-1.8	-2.7	-1.7	-1.0	-4.1	-3.2	-3.6	-1.5	-3.8	-4.5	-3.4	-2.3	-3.1	-2.0	-4.4	-4.2	-2.9
Blood Platelet Count	3.3	38.8	69.9	6.4	8.0	5.5	4.0	4.2	7.8	8.4	6.4	3.7	5.7	6.7	8.0	5.6	7.4	7.8	4.0	5.5	3.1
Chest pain or discomfort	3.3	4.8	9.4	1.6	2.7	2.6	3.0	2.0	3.0	2.2	2.3	2.1	1.1	2.0	2.6	1.1	1.9	3.1	1.0	2.1	0.4
HbA1C	3.2	3.5	9.4	-2.0	-1.4	-2.2	-3.1	-1.9	-2.6	-2.0	-1.8	-1.6	-1.9	0.0	-2.2	-1.2	-2.2	-1.8	-1.4	-1.9	-0.6
Falls in the last year	3.2	4.4	8.5	2.5	1.4	2.4	1.5	2.1	2.8	2.1	1.3	1.9	2.2	2.9	2.3	1.8	2.7	1.6	2.0	1.6	1.4
Hearing aid user	3.1	3.5	7.6	1.4	2.8	1.7	1.1	1.3	2.4	2.6	1.8	1.9	1.4	1.9	2.4	1.5	2.2	2.6	0.9	1.5	0.4
Blood Eosinophil Count	2.9	22.4	36.0	-5.6	-3.2	-5.4	-4.5	-6.0	-5.4	-4.9	-4.8	-3.9	-5.5	-5.8	-4.5	-3.3	-4.7	-4.1	-4.1	-5.0	-3.3
Chronotype (morning person)	2.9	6.7	14.1	3.0	2.2	3.0	2.4	2.0	3.5	3.8	2.6	1.3	2.5	3.1	3.1	1.4	2.7	2.4	2.2	2.7	0.9
Chronic bronchitis/emphysema (father)	2.9	3.4	10.3	-2.0	-1.6	-1.7	-0.0	-0.5	-1.8	-1.8	-1.8	0.1	-1.8	-1.5	-0.6	-3.2	-2.2	-1.6	-2.3	-1.8	-3.2
Frequency of depressed mood in last 2 weeks	2.8	3.9	7.1	2.2	2.2	2.1	0.6	2.5	1.7	2.1	2.7	1.7	1.7	1.4	2.1	2.2	2.2	2.1	1.2	2.1	1.7
Number of full sisters	2.8	3.4	6.0	2.0	2.4	1.2	0.3	0.6	2.4	2.5	2.4	0.9	1.8	1.8	2.4	1.9	2.3	2.0	1.6	1.7	1.1
Number of live births	2.7	3.8	8.7	1.3	2.9	1.7	1.6	1.2	2.9	2.9	1.4	1.8	1.4	1.8	2.6	1.8	2.4	2.5	1.3	0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	6.4	2.3	1.3	1.9	0.2	1.3	1.7	1.9	1.9	0.7	2.3	2.0	1.4	1.8	1.4	1.2	2.5	2.1	2.3
Illnesses of siblings: Diabetes	2.7	3.3	8.5	-1.9	-2.3	-1.9	0.1	-1.7	-0.9	-2.4	-1.5	-1.1	-1.7	-1.5	-1.8	-2.9	-2.8	-2.3	-0.6	-1.0	-1.7
Birth weight	2.6	5.7	11.3	-2.5	-3.0	-1.7	-0.7	-0.4	-2.6	-3.0	-2.9	-0.9	-2.3	-2.2	-2.2	-3.4	-2.7	-2.7	-2.4	-2.2	-2.9
Fluid intelligence score	2.5	5.1	10.8	-3.3	-0.3	-2.8	-2.5	-2.3	-2.5	-1.5	-2.0	-3.1	-2.7	-2.6	-1.6	-0.8	-1.1	-0.4	-2.9	-2.7	-2.0
Age at last live birth	2.5	3.7	10.2	-1.6	-2.1	-1.2	-0.2	-0.7	-1.6	-2.7	-2.2	0.2	-2.5	-1.4	-1.7	-3.2	-2.5	-1.0	-2.5	-1.3	-2.4
Pain experienced in last month	2.5	4.1	9.1	-1.7	-2.9	-1.1	-0.9	-0.6	-2.4	-3.0	-2.1	-1.2	-1.4	-1.8	-2.7	-2.3	-2.5	-2.4	-1.5	-2.1	-1.7
Alcohol drinker status: Never	2.4	2.9	7.8	1.7	1.4	0.9	-1.6	-0.9	1.1	1.9	1.9	-0.1	0.9	1.8	0.8	2.2	1.7	2.3	1.8	2.4	2.8
Illnesses of father: Heart disease	2.3	3.2	9.0	0.6	2.9	1.7	1.4	1.2	2.0	2.2	1.6	-0.5	1.2	0.8	1.1	3.0	2.2	2.7	1.0	1.0	1.8
Qualifications: nursing, teaching	2.3	3.6	6.9	-1.9	-1.9	-2.5	-0.0	-2.2	-1.4	-2.4	-1.9	-2.6	-2.2	-1.1	-1.4	-2.6	-2.2	-1.4	-1.7	-1.1	-1.9
Alcohol usually taken with meals	2.2	3.6	10.7	1.5	1.5	0.8	0.9	0.8	2.0	1.6	2.3	0.1	2.5	2.2	1.9	2.0	1.8	0.8	3.3	2.5	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.5	-1.7	-1.4	-1.2	-0.6	-1.9	-1.6	-1.4	-1.9	-1.8	-1.9	-1.8	-2.0	-1.2	-1.6	-1.4	-1.5	-2.1	-1.2
Medication: Atorvastatin	2.1	2.6	5.7	1.9	1.6	1.1	1.7	-0.4	2.4	2.0	1.7	-0.2	1.6	2.1	1.6	1.4	1.4	1.6	1.8	1.8	1.3
Illnesses of father: High blood pressure	2.1	2.6	8.1	2.2	-0.3	0.8	1.6	0.8	1.7	0.8	1.1	1.6	2.0	2.9	1.5	0.6	1.5	0.3	2.4	2.2	1.5
Schizophrenia (2014)	2.0	4.3	8.2	2.7	2.4	1.8	2.6	1.8	2.9	2.2	2.1	-0.0	2.2	0.0	2.8	1.6	2.3	2.3	1.5	2.1	1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.5	2.0	0.1	1.3	0.8	1.9	1.2	0.6	1.9	1.6	2.0	1.5	0.8	1.3	0.7	-0.1	2.1	1.6	2.1
Risk taking	2.0	2.9	5.1	1.9	1.9	1.4	0.9	1.2	2.1	1.9	2.2	1.0	1.4	1.7	2.1	1.5	1.5	1.7	2.0	2.1	1.5
Age at First Birth	1.9	2.8	6.0	-1.3	-1.5	-0.2	-1.6	-1.5	-1.8	-1.6	-2.1	-2.2	-2.2	-1.5	-2.4	-1.6	-1.8	-0.5	-1.6	-1.9	-1.3
Depression (self-reported)	1.9	2.2	5.8	1.3	2.4	1.3	-1.0	-0.2	1.3	2.1	1.7	0.4	0.7	1.0	1.2	2.3	1.9	2.4	0.8	1.2	1.6
Schizophrenia vs Biploar Disorder	1.8	2.3	4.1	1.9	1.8	1.3	1.2	0.9	1.8	2.0	1.7	0.9	1.6	0.0	1.9	1.6	2.0	1.8	0.7	1.8	0.9
Lupus	1.8	2.7	4.2	1.4	1.4	1.8	1.9	1.6	1.9	1.2	2.0	2.0	1.9	0.0	1.4	2.0	1.7	1.4	1.6	1.4	1.9
Blood White Count	1.8	13.1	22.7	4.2	4.3	3.2	0.2	0.6	4.0	4.7	4.0	1.5	3.1	4.4	4.0	3.7	3.9	4.8	3.3	4.1	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.9	1.3	2.0	1.9	0.6	0.7	1.5	1.7	2.4	1.7	1.4	1.0	1.2	2.2	1.2	1.6	2.2	1.7	2.3
Alzheimer’s Disease (in father)	1.7	1.8	3.3	-1.5	-0.6	-1.0	0.1	-1.5	-0.9	-0.8	-1.7	-1.7	-1.4	-1.4	-1.3	-1.7	-1.5	-0.9	-1.2	-1.8	-1.8
Diabetes (father)	1.7	2.1	6.4	-1.0	-2.5	-0.6	-0.2	-0.2	-0.8	-1.9	-2.1	0.8	-1.6	-0.5	-1.5	-2.5	-1.6	-1.5	-1.1	-1.1	-1.6
Headache pain in last month	1.7	2.9	6.6	1.6	1.4	0.9	1.7	1.0	1.6	1.8	2.4	2.6	1.5	1.7	1.9	1.4	1.1	1.1	1.9	2.2	1.9
Age at first live birth	1.7	2.9	9.0	-1.2	-1.9	-1.6	-0.1	0.1	-1.5	-2.0	-2.0	0.6	-2.1	-0.9	-0.9	-3.0	-1.7	-0.8	-2.7	-1.1	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	1.9	5.0	1.3	0.8	1.6	1.3	2.2	1.4	1.8	1.3	1.8	1.8	1.1	0.8	1.3	1.1	0.4	1.7	1.2	1.3
Worry too long after embarrassment	1.6	2.6	7.4	-1.9	-0.1	-0.6	-2.7	-0.8	-2.4	-0.9	-1.4	-2.1	-2.2	-2.4	-1.4	-0.7	-1.1	0.2	-2.3	-1.3	-1.0
Wheeze or whistling in the chest in last year	1.6	2.8	6.0	-1.7	-2.4	-1.6	-1.0	-0.8	-1.9	-2.5	-1.5	0.3	-2.1	-1.8	-1.8	-1.9	-2.0	-2.0	-1.3	-0.6	-0.8
Number of children fathered	1.6	1.8	4.7	1.1	0.4	1.8	1.0	1.9	1.7	0.9	1.0	2.2	1.9	1.7	0.6	0.9	0.9	0.6	1.9	0.8	1.3
Bipolar Disorder or Schizophrenia	1.4	3.5	9.0	2.5	1.8	1.5	3.0	1.4	2.6	1.7	1.7	-0.1	2.0	2.4	2.4	1.1	1.7	1.9	1.2	1.6	0.6
Blood Red Count	1.4	13.7	20.5	4.0	3.9	3.0	2.7	2.9	4.5	4.1	4.5	1.8	3.7	4.1	4.4	3.2	4.1	3.9	3.1	4.4	2.7
Shortness of breath walking on level ground	1.4	1.7	5.3	0.6	1.5	2.0	-0.5	2.0	0.5	1.4	0.8	2.3	0.7	0.3	0.6	1.9	1.8	1.9	-0.3	0.0	0.5
Commuting to job workplace: Walk	1.4	1.5	7.5	-0.8	2.7	-0.2	-1.0	0.4	0.2	1.5	0.2	-1.2	-0.2	-0.7	1.2	2.0	1.7	1.8	-1.0	-0.7	-0.3
Respiratory disease	1.3	2.9	6.5	-1.4	-2.1	-2.5	-1.2	-1.3	-1.4	-2.0	-1.9	0.6	-1.8	-0.9	-0.1	-2.5	-1.1	-2.1	-1.7	-0.7	-2.2
Angina	1.3	1.7	4.1	1.4	1.3	1.6	1.2	-0.0	1.7	1.4	1.3	0.4	1.2	1.5	0.7	1.2	1.2	2.0	1.0	1.4	1.1
Number of incorrect matches in round	1.3	2.2	7.2	0.9	2.6	1.5	1.5	0.8	1.9	1.9	1.0	0.6	0.6	1.3	2.0	0.9	1.8	2.7	0.3	0.9	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.6	1.0	2.1	1.4	1.4	1.1	1.7	1.4	2.4	2.3	0.6	1.0	2.1	0.5	1.1	1.9	0.7	1.4	-0.1
Medication: Blood pressure	1.3	2.5	5.6	0.8	2.4	1.7	1.3	1.3	2.1	2.0	1.5	1.5	1.6	1.4	2.0	1.4	1.9	1.8	1.3	1.2	0.5
High cholesterol (Self-reported)	1.3	2.2	5.8	2.3	0.3	1.0	1.7	1.1	1.9	1.7	1.7	0.8	2.3	1.7	1.4	0.7	0.8	-0.2	2.4	1.5	1.0
Cholesterol lowering medication	1.3	1.9	5.0	1.5	1.7	-0.4	1.2	-0.5	2.0	1.9	1.3	-1.5	1.5	1.6	2.2	0.5	1.1	0.6	1.7	1.0	-0.1
Bipolar Disorder (2018)	1.2	1.8	3.5	-1.0	-1.2	-1.4	-0.2	-1.5	-1.1	-1.6	-1.6	-1.9	-1.3	0.0	-1.1	-1.6	-1.4	-1.1	-1.4	-1.7	-1.7
HDL Cholesterol	1.2	2.1	6.5	1.2	0.8	2.1	0.0	1.7	0.6	0.9	1.8	1.6	1.9	0.0	-0.0	1.9	0.8	0.9	2.0	1.5	2.6
Impedance of leg (right)	1.2	5.6	11.6	-2.5	-2.0	-2.1	-0.5	-1.5	-2.3	-1.9	-3.4	-1.8	-2.5	-2.7	-2.2	-2.4	-2.4	-2.4	-2.5	-3.3	-2.7
Average weekly fortified wine intake	1.2	1.4	3.8	-1.6	-1.5	-0.6	-0.2	-0.5	-1.7	-1.3	-1.2	-0.6	-0.9	-1.5	-2.0	-0.4	-1.5	-1.6	-0.3	-1.1	0.4
Impedance of leg (left)	1.2	5.9	11.9	-2.3	-2.3	-2.2	-0.5	-1.6	-2.4	-2.0	-3.4	-1.7	-2.5	-2.6	-2.2	-2.8	-2.6	-2.7	-2.4	-3.2	-2.8
Hearing difficulty/problems with background noise	1.2	1.9	3.3	1.0	0.7	1.3	1.8	1.8	1.8	0.8	1.5	1.8	1.1	1.7	1.4	0.7	1.0	1.2	1.4	1.6	1.1
Illnesses of siblings	1.2	1.7	6.2	1.4	1.1	1.6	-0.1	1.8	0.3	1.4	1.3	1.0	1.5	0.7	0.4	2.5	1.5	1.0	0.9	0.3	2.1
Forced vital capacity (FVC), Best measure	1.2	4.4	11.3	-1.5	-3.1	-1.6	-0.3	-0.6	-2.4	-3.0	-2.3	-0.1	-1.9	-1.4	-2.1	-3.4	-2.7	-2.4	-1.6	-1.5	-2.3
Age started oral contraceptive pill	1.2	1.5	3.2	-1.5	-0.2	-1.7	-1.5	-1.5	-1.2	-0.9	-1.3	-0.9	-1.4	-1.2	-0.6	-0.8	-0.5	-0.7	-1.1	-1.7	-1.8
Reaction Time	1.1	2.1	4.2	1.4	2.0	1.3	0.7	0.5	1.8	1.9	1.6	0.5	1.5	1.5	1.3	1.8	1.6	1.9	1.3	0.8	1.1
Sensitivity / hurt feelings	1.1	1.8	8.7	0.5	3.0	1.0	-0.2	0.8	1.2	2.1	1.5	-0.7	0.7	0.3	2.1	1.4	1.5	2.0	0.2	0.6	-0.1
Forced vital capacity (FVC)	1.1	4.1	11.3	-1.1	-3.3	-1.3	0.8	-0.2	-2.2	-3.0	-2.1	-0.6	-1.5	-1.2	-2.0	-3.4	-2.8	-2.7	-1.4	-1.1	-1.9
Exposure to tobacco smoke at home	1.1	1.2	2.8	-1.0	-0.6	-0.6	0.3	-0.2	-0.9	-1.1	-1.3	-0.7	-1.4	-1.6	-1.1	-1.0	-1.2	-0.8	-1.6	-1.7	-1.4
Peak expiratory flow (PEF)	1.1	2.5	6.1	-1.1	-2.5	-1.8	-0.4	-1.7	-1.5	-2.1	-1.4	-2.2	-1.0	-1.0	-1.9	-1.6	-1.9	-2.3	-0.1	-0.5	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.9	0.9	2.2	0.5	-0.1	-0.6	1.3	1.6	2.0	-1.1	0.7	0.6	1.4	0.9	0.9	1.6	1.2	1.3	0.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.8	1.1	-0.2	-0.4	1.0	0.0	0.7	0.2	1.2	0.8	1.7	0.6	0.4	1.3	0.3	-1.3	2.4	1.0	2.2
Neuroticism	1.0	2.5	8.5	0.9	2.9	1.7	-0.5	1.2	1.3	2.2	2.1	0.2	0.9	0.5	2.0	1.9	1.8	2.4	0.6	1.1	0.8
Ever had hysterectomy (womb removed)	1.0	1.2	5.4	0.3	2.3	0.4	0.2	-0.4	1.2	1.9	0.6	-0.3	0.1	0.2	1.3	1.7	1.2	1.5	0.5	0.1	0.7
Relative age voice broke	1.0	1.5	4.7	-1.8	-0.4	-1.6	-2.2	-1.5	-1.5	-1.1	-1.2	-0.6	-1.6	-1.3	-1.3	-0.1	-0.4	-0.3	-1.1	-1.2	-0.3
Serious illness, injury or assault to yourself	1.0	1.3	3.6	0.7	1.2	0.7	1.9	1.3	1.4	1.0	1.3	0.5	1.1	0.9	1.8	0.8	1.1	0.5	1.1	1.1	0.4
Financial difficulties in last 2 years	1.0	1.3	6.5	1.4	-0.5	0.2	1.0	0.6	0.6	0.3	1.8	0.3	1.1	1.1	0.9	0.1	0.0	-0.4	1.8	2.5	1.5
Prospective memory result	1.0	1.3	2.7	1.6	1.0	1.0	0.8	1.2	1.5	1.6	1.1	1.1	1.2	1.1	1.6	0.4	1.1	0.6	0.8	1.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	9.1	-1.0	-3.0	-1.8	0.1	-1.0	-1.8	-2.7	-1.8	-1.1	-1.4	-0.9	-1.7	-3.0	-2.4	-2.6	-0.8	-0.8	-1.6
Tense / ‘highly strung’	1.0	1.6	6.0	0.8	2.4	1.1	0.9	1.4	1.7	1.6	1.5	0.9	1.2	0.8	1.9	0.7	1.0	1.5	0.7	0.6	-0.4
Medication: Amlodipine	1.0	1.4	4.4	0.8	1.2	1.5	0.1	1.3	0.6	1.1	0.8	1.3	1.4	0.9	0.5	2.1	1.3	0.9	1.2	0.4	1.8
Overall health rating	1.0	2.1	9.3	1.5	1.2	1.4	0.5	1.6	1.2	1.3	1.3	3.1	0.8	1.2	1.7	1.5	1.9	1.4	0.7	1.3	1.1
Hypertension (Self-reported)	1.0	2.6	5.2	1.9	0.8	2.2	1.3	1.1	1.6	1.1	1.5	2.2	2.2	2.3	1.2	1.0	1.1	0.9	2.2	1.7	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	7.4	0.1	-2.7	0.5	0.6	1.4	-1.1	-2.1	-0.5	2.4	-0.7	-0.5	-1.4	-2.3	-2.0	-1.9	-0.3	0.3	-0.3
Mood swings	1.0	1.8	5.8	1.2	0.7	1.8	-0.2	1.6	0.7	0.6	2.3	2.4	1.1	1.1	1.0	0.6	0.5	1.1	1.3	1.9	1.3
Back pain experienced in last month	1.0	1.4	3.7	0.9	1.8	0.5	0.9	0.1	1.5	1.9	1.2	-0.2	0.8	0.9	1.5	1.5	1.4	1.0	1.4	0.9	1.1
Asthma (self-reported)	1.0	2.0	4.2	-2.0	-1.0	-2.0	-1.1	-1.5	-1.2	-1.7	-1.4	-0.4	-1.9	-1.3	-0.5	-1.6	-1.1	-1.0	-1.6	-0.8	-1.6
Wears glasses or contact lenses	1.0	1.1	5.0	0.0	2.2	0.8	0.3	0.4	1.1	1.8	0.2	0.4	1.1	0.6	1.5	1.2	1.6	1.3	0.3	-0.5	-0.4
Mother’s age at death	1.0	1.2	4.5	0.5	1.7	1.7	-0.6	0.7	0.9	1.5	0.8	-0.0	0.6	0.5	0.4	1.6	1.1	2.1	0.5	0.7	1.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.0	0.4	2.0	0.6	0.9	0.7	1.2	1.7	0.9	-1.8	0.9	0.7	1.0	1.6	1.2	1.5	0.6	0.5	0.7
Medication: Lisinopril	1.0	1.3	3.7	0.9	1.1	1.9	0.7	0.6	1.3	1.1	1.1	1.0	1.1	1.3	0.4	1.2	0.9	1.4	1.4	0.9	1.4
Coronary Artery Disease (CAD)	0.9	1.1	3.8	0.8	1.2	-0.9	1.2	0.2	1.4	1.3	1.4	0.2	1.4	0.0	2.0	0.3	0.9	0.6	1.0	1.3	-0.1
Hearing difficulty/problems: Yes	0.9	1.3	8.2	0.1	1.0	1.1	1.0	1.3	1.4	0.6	0.7	2.9	0.6	1.0	1.1	0.8	1.1	1.0	0.9	1.0	0.7
Relative age of first facial hair	0.9	1.9	5.0	-1.2	-1.3	-1.3	-2.2	-2.0	-1.8	-1.3	-1.7	-1.3	-1.6	-1.2	-1.7	-0.2	-0.8	-1.1	-0.8	-1.5	0.1
Asthma	0.9	1.8	3.6	-1.9	-0.9	-1.9	-1.2	-1.4	-1.2	-1.6	-1.4	-0.5	-1.8	-1.2	-0.5	-1.5	-1.1	-0.9	-1.5	-0.8	-1.5
Medication: Lansoprazole	0.9	1.1	4.2	0.8	0.6	1.7	-0.5	0.6	0.7	0.7	0.8	0.5	1.1	0.7	-0.2	1.8	0.9	0.5	1.4	0.6	2.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	7.6	0.9	0.4	1.1	2.8	2.7	1.4	0.8	1.1	2.0	1.2	0.3	1.5	0.8	1.0	-0.3	0.7	1.2	0.8
Angina (self-reported)	0.9	1.2	3.7	1.4	1.1	1.4	1.0	-0.4	1.6	1.3	1.0	0.2	0.9	1.4	0.5	0.8	0.9	1.9	0.8	1.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.4	-0.9	-0.7	0.8	-0.1	0.1	-0.5	-0.9	-2.0	0.0	-0.9	-0.6	-1.3	-0.9	-0.7	0.1	-1.5	-2.1	-1.6
Knee pain experienced in last month	0.9	1.4	5.6	-0.9	0.1	-1.0	-1.7	-1.4	-0.8	-0.6	-1.1	-0.1	-2.1	-1.3	0.1	-1.0	-0.0	0.3	-2.4	-1.0	-1.9
Waist Hip Ratio (WHR)	0.8	3.5	14.8	-0.6	-3.8	-2.1	-0.0	-0.3	-2.0	-2.9	-1.3	1.0	-0.5	-0.7	-1.6	-2.6	-2.6	-3.5	-0.0	0.3	-0.1
Allergy or Eczema	0.8	2.0	6.5	-1.0	-2.5	-2.0	-0.5	-1.3	-1.1	-1.8	-1.9	-0.0	-0.6	-0.6	-1.0	-1.9	-1.1	-2.5	-0.7	-0.4	-1.1
Lung FEV1/FVC ratio	0.8	4.3	8.7	1.9	2.5	2.4	1.0	0.7	3.0	2.6	1.9	0.5	1.5	2.1	1.8	2.4	2.4	2.8	2.0	1.9	2.0
Diabetes (mother)	0.8	1.1	3.5	1.1	0.1	0.2	0.3	1.4	1.0	0.2	1.2	1.7	1.0	1.1	1.6	0.5	1.1	0.0	0.7	1.9	0.9
Maternal smoking around birth	0.8	1.2	2.9	1.1	1.3	1.1	-0.2	1.0	1.0	1.5	1.5	0.6	0.8	1.3	1.7	0.2	1.1	1.5	0.6	1.3	-0.4
High blood pressure	0.8	2.2	4.7	1.6	1.0	2.2	1.1	0.9	1.5	1.1	1.2	2.0	2.1	2.0	1.1	1.1	1.1	0.9	2.0	1.4	1.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.7	-0.7	-1.7	-0.1	-0.4	0.2	-1.2	-1.5	-1.3	0.5	-1.1	-0.7	-1.3	-1.0	-0.9	-0.8	-1.0	-0.7	-0.5
Pain all over the body in last month	0.8	0.9	2.3	-1.3	-0.4	-0.7	-0.5	0.2	-0.7	-0.6	-1.3	0.1	-1.0	-1.1	-0.8	-1.1	-0.6	-0.8	-1.0	-1.5	-1.5
Standing height	0.8	7.8	16.2	-2.9	-3.5	-1.8	0.5	-0.5	-3.0	-4.0	-2.7	-0.5	-2.8	-3.0	-3.1	-3.8	-4.0	-3.5	-2.2	-2.1	-2.4
Loud music exposure frequency	0.8	0.9	3.8	-0.6	-1.5	0.1	-1.1	-0.2	-1.2	-1.4	-1.0	-0.4	-0.6	-0.7	-1.9	-0.9	-1.2	-0.8	-0.3	-0.7	-0.1
Medication: Ibuprofen	0.8	0.9	7.3	-0.4	0.0	0.0	-2.7	-0.2	-1.1	-0.2	-1.1	1.0	-1.4	-0.2	-0.4	0.0	0.6	0.9	-1.2	-0.5	-0.4
Had major operations	0.8	0.9	2.1	-0.9	-0.9	-1.4	-0.5	-1.4	-1.0	-1.1	-1.3	-0.2	-1.4	-0.8	-0.4	-0.7	-0.4	-1.0	-0.7	-0.7	-0.9
Medication for cholesterol	0.8	1.2	2.7	-0.8	-1.0	-0.6	-1.1	-0.9	-1.6	-1.3	-1.4	-0.3	-1.4	-1.4	-1.5	-0.5	-0.9	-0.6	-1.5	-1.2	-0.5
Miserableness	0.8	1.4	5.7	0.6	1.3	1.5	0.7	2.4	0.7	1.3	1.3	2.0	1.1	0.2	1.5	1.0	1.2	0.8	0.2	0.8	0.4
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.8	-1.6	-1.0	-1.9	-1.0	-0.9	-1.5	-1.2	-1.3	-2.0	-2.1	-2.1	-1.3	-1.0	-1.1	-0.9	-2.2	-1.5	-1.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.7	1.0	0.6	0.9	0.9	0.6	1.4	0.7	0.6	0.9	0.9	1.6	1.3	0.4	1.4	1.2	0.6	1.4	0.3
Heart disease (siblings)	0.8	0.9	4.6	-0.7	0.5	-1.5	-0.9	-1.7	-0.3	0.1	-0.5	-2.1	-1.1	-0.8	0.2	-0.6	0.1	0.2	-0.7	-0.4	-1.4
Depression (Nagel 2018)	0.7	1.1	5.0	0.9	0.8	1.3	1.5	2.2	1.0	0.8	1.4	1.0	1.0	0.0	1.1	0.1	0.3	0.4	0.5	1.2	0.2
Bipolar Disorder (2011)	0.7	0.6	4.8	0.6	-0.5	-0.2	2.2	0.2	0.5	-0.2	0.2	-1.8	0.5	0.0	0.7	-0.9	-0.3	-0.6	0.5	0.5	-0.4
Primary Biliary Cirrhosis	0.7	1.0	4.7	-0.3	0.5	-2.0	-2.2	-1.9	-0.5	0.5	-0.0	-1.2	-0.7	0.0	1.1	-0.5	0.3	-0.2	-0.4	-0.2	-1.3
Cardiovascular Disease	0.7	2.3	4.2	2.0	1.1	1.0	0.7	0.3	1.5	1.6	2.0	1.9	2.0	2.0	1.7	0.8	1.2	1.0	2.1	2.0	1.0
Hypothyroidism (self reported)	0.7	1.7	8.5	0.8	0.3	1.1	2.2	2.9	1.1	0.7	1.1	2.1	1.3	0.3	1.3	0.7	0.7	-0.4	0.9	1.3	1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.3	5.2	-0.9	-1.2	-1.6	0.3	-0.7	-0.7	-0.8	-0.7	0.7	-1.4	-0.7	0.1	-2.3	-1.1	-0.9	-1.4	-0.1	-2.1
Average weekly spirits intake	0.7	0.8	3.9	-0.2	-1.6	-0.5	0.7	-0.5	-0.0	-1.3	-0.7	-0.9	-0.7	0.4	-0.1	-2.0	-0.9	-0.7	-0.8	0.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.8	-1.4	-0.6	-0.8	-0.6	-0.4	-1.3	-1.3	-1.0	0.2	-1.2	-1.1	-0.7	-0.3	-0.5	-0.6	-0.9	-0.7	-0.3
Qualifications: CSEs or equivalent	0.7	0.9	3.0	1.0	-0.2	1.1	1.7	1.7	0.5	0.2	1.6	1.4	0.2	0.5	0.3	-0.1	-0.3	0.4	0.4	1.6	0.9
Medication: Levothyroxine sodium	0.7	1.2	4.1	1.2	0.1	1.8	1.9	2.0	1.1	0.6	0.9	1.1	0.8	0.6	0.6	0.5	0.5	0.4	0.4	1.3	1.1
Sitting height	0.7	4.9	9.6	-2.1	-2.7	-1.0	1.3	0.2	-2.3	-3.1	-2.1	0.2	-2.1	-2.3	-2.4	-3.0	-3.1	-2.8	-2.0	-2.1	-2.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.2	-1.4	-1.1	-1.3	-0.2	-0.9	-1.2	-1.2	-1.8	-1.8	-1.2	-0.9	-1.4	-1.2	-1.3	-0.7	-1.2	-1.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	4.0	-1.2	-0.5	-2.0	-1.2	-0.9	-1.0	-0.6	-0.6	-0.6	-1.0	-0.9	-0.3	-0.6	-0.4	-0.8	-0.7	-0.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	6.3	-0.3	-0.2	-0.1	-2.5	-0.2	-1.0	-0.2	-1.3	1.0	-1.4	-0.1	-0.4	0.1	0.8	0.9	-1.4	-0.8	-0.5
Length of working week for main job	0.7	0.8	2.3	0.9	0.2	0.9	0.8	1.5	0.9	0.3	1.0	1.0	1.1	0.9	1.2	0.5	1.0	0.2	0.4	1.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.4	-1.0	-0.9	-1.9	0.9	-0.9	-0.7	-0.9	-1.1	-2.1	-0.4	-0.5	-1.1	-0.7	-1.2	-1.2	-0.2	-0.8	-0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.5	-1.1	-0.8	-1.0	-0.8	-1.2	-0.9	-1.1	-1.0	-0.9	-1.1	-1.1	-0.7	-0.8	-0.9	-0.9	-0.7	-0.9	-0.6
Mean time to correctly identify matches	0.7	1.3	3.3	0.9	1.8	1.1	0.1	0.3	1.3	1.7	1.0	0.4	1.1	1.1	1.0	1.6	1.6	1.7	0.8	0.3	0.6
Financial situation satisfaction	0.7	0.9	2.8	-0.8	-1.5	-1.2	-0.5	-0.5	-1.3	-1.7	-0.6	-0.2	-0.4	-0.8	-0.9	-0.7	-1.1	-1.6	-0.1	-0.8	-0.1
Commuting to job workplace: Cycle	0.7	0.9	2.4	1.2	-0.4	1.3	0.3	1.5	0.6	0.6	0.8	1.5	1.2	0.9	0.3	-0.0	0.1	-0.5	1.3	1.0	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.8	0.4	0.8	0.5	-1.4	0.3	0.1	0.4	1.0	1.5	0.8	0.5	0.2	1.7	0.9	0.5	1.5	0.3	1.5
Impedance of whole body	0.7	3.7	6.9	-2.0	-1.5	-1.4	-0.7	-1.6	-2.1	-1.4	-2.6	-1.9	-2.2	-2.6	-2.2	-1.4	-2.0	-1.8	-2.1	-2.6	-1.5
Depressed Affect (Nagel 2018)	0.6	1.4	4.2	0.5	1.2	1.6	-0.7	2.1	0.3	0.7	1.8	1.9	0.8	0.0	1.2	1.0	1.0	1.2	0.2	1.3	0.9
Crohns Disease (2017)	0.6	1.3	3.5	1.5	0.6	0.5	1.2	-0.5	1.5	1.4	1.4	0.8	1.0	1.6	1.2	-0.4	0.1	0.5	1.9	1.8	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.2	0.5	0.8	-0.4	1.5	0.5	1.3	1.0	0.3	0.1	0.8	0.0	1.4	-0.4	0.6	-0.2	0.8	-0.4	-1.2
Vitamin and mineral supplements	0.6	0.8	2.6	-1.6	0.0	-0.9	0.3	-0.9	-0.7	-0.9	-0.6	-0.7	-0.8	-1.4	-0.6	-0.6	-1.1	-0.6	-0.5	-1.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.7	0.6	0.0	1.1	1.1	1.9	0.7	0.2	1.1	1.7	0.6	0.6	0.6	-0.8	-0.2	0.2	0.3	0.9	-0.4
Mouth/teeth dental problems	0.6	0.9	2.4	-1.0	-0.4	-1.1	-1.6	-1.0	-1.5	-0.8	-0.6	-1.1	-1.0	-1.2	-0.9	-0.1	-0.6	-0.5	-1.2	-0.8	-0.3
Heart attack	0.6	0.7	2.2	0.3	0.8	0.4	-1.4	0.3	0.1	0.4	0.9	1.4	0.7	0.4	0.3	1.5	0.9	0.5	1.3	0.2	1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	2.6	-0.5	0.4	-1.5	-1.5	-1.6	-0.6	0.3	-0.7	-1.2	-0.6	-0.4	-0.1	-0.2	0.4	0.1	-1.3	-0.9	-1.5
Breastfed as a baby	0.6	0.8	3.8	-1.9	0.6	-0.7	-0.2	0.3	-0.6	-0.5	-0.7	-1.0	-1.0	-1.4	-0.4	0.1	-0.2	0.2	-1.4	-1.2	-0.9
Hair/balding pattern: Pattern 4	0.6	1.5	4.9	1.5	0.5	0.7	-0.4	1.0	0.4	1.1	1.3	2.2	1.4	1.1	0.7	1.7	1.3	0.7	1.0	1.2	1.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.9	0.2	-0.8	-1.3	-0.3	-1.0	-0.2	-0.6	-0.8	-1.1	-1.3	-0.3	0.2	0.1	0.0	-1.5	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.4	0.5	0.2	1.0	0.8	1.5	0.9	0.4	0.3	1.6	0.6	1.0	0.7	-0.5	0.5	0.8	0.1	1.0	-0.5
Emphysema/chronic bronchitis	0.6	0.7	2.2	-0.5	-1.5	-0.7	-1.3	-0.4	-0.9	-1.4	-1.0	0.9	-0.7	-0.2	-0.7	-0.5	-0.2	-1.0	-0.5	-0.5	-0.2
Mineral and other dietary supplements	0.6	0.8	3.4	0.2	-1.8	-0.1	-0.6	-0.5	-0.8	-1.4	-0.2	1.5	-0.0	-0.3	-0.8	-0.9	-0.9	-1.6	0.4	0.1	0.2
Osteoarthritis (self-reported)	0.6	0.8	3.1	-0.0	1.7	1.0	-0.0	0.4	0.7	1.4	0.1	0.6	-0.3	-0.3	0.4	1.4	1.1	1.8	-0.7	-0.2	0.3
Medication: Gliclazide	0.6	0.7	2.4	0.6	-0.3	0.7	1.2	0.8	0.6	0.3	1.3	1.1	1.0	0.5	-0.1	-0.2	-0.6	-0.6	1.5	1.0	0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	3.4	-0.6	-0.9	-1.3	-1.9	-0.7	-1.1	-1.0	0.0	0.2	-0.4	-1.1	-0.4	-0.3	-0.8	-1.4	-0.2	-0.0	0.2
Smoking status: Current	0.6	0.9	3.9	-0.3	-0.9	1.4	-0.6	0.9	-1.2	-1.1	-1.0	0.2	-0.3	-0.9	-2.0	0.6	-0.7	-0.3	-0.2	-0.9	1.2
Average weekly champagne plus white wine intake	0.6	0.9	3.6	-0.3	1.1	1.2	-0.7	0.8	0.1	0.5	0.5	1.7	0.4	0.1	-0.0	1.9	1.2	1.1	0.5	-0.1	1.3
Fractured/broken bones in last 5 years	0.6	0.7	2.6	0.6	-0.9	1.6	0.2	1.6	-0.0	-0.4	0.7	0.8	0.7	0.1	-0.8	0.0	-0.8	-0.7	0.9	0.9	1.3
Alcohol drinker status: Previous	0.6	0.7	1.9	-0.6	-0.9	0.0	-1.4	-1.0	-1.3	-1.0	-0.6	-0.5	-0.8	-0.7	-1.3	0.1	-0.8	-0.5	0.1	-0.1	1.0
Neuroticism (Nagel 2018)	0.5	1.1	4.5	0.0	2.1	1.2	-1.0	1.4	0.2	0.9	1.5	0.9	0.4	-0.3	1.1	1.1	0.8	1.5	-0.3	0.7	0.4
Worry (Nagel 2018)	0.5	1.0	6.9	-0.2	2.6	0.3	-0.2	-0.1	0.6	1.3	1.2	-0.9	0.1	0.0	1.3	1.0	0.8	2.0	-0.3	0.3	-0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.6	-0.5	-0.3	0.1	-0.9	-0.6	-0.2	-0.5	-1.4	-0.6	-1.2	-0.2	-0.6	-0.9	-0.2	0.4	-1.6	-1.3	-1.5
Major Depression (MDD)	0.5	0.6	3.6	0.9	0.2	1.9	0.8	0.6	1.1	0.9	0.5	0.9	0.6	0.0	0.1	0.1	-0.1	0.6	0.9	0.4	0.5
Height	0.5	10.6	22.5	-3.6	-3.6	-1.2	0.3	-0.6	-3.9	-4.6	-3.3	-1.0	-3.1	-3.8	-4.4	-3.9	-4.7	-3.1	-3.2	-2.9	-2.5
Smoking Status	0.5	1.2	6.9	0.7	0.2	2.6	-0.9	1.8	-0.5	0.1	-0.2	0.5	0.4	-0.1	-1.4	1.6	0.2	1.0	0.1	-0.5	1.7
Medication for hormone replacement therapy	0.5	0.6	1.4	-0.7	-1.0	0.3	0.1	1.0	-1.0	-0.9	-0.5	-0.5	0.0	-0.9	-1.2	0.2	-0.8	-1.2	-0.2	-0.8	0.7
Hand grip strength (right)	0.5	1.5	4.2	-0.5	-2.0	-1.5	-1.4	-0.6	-1.4	-1.8	-1.4	0.3	-1.0	-0.5	-1.1	-1.7	-1.0	-1.4	-0.9	-0.6	-1.1
Current tobacco smoking	0.5	0.9	3.4	-0.0	-1.0	1.5	-0.9	1.0	-1.1	-1.1	-0.7	0.6	-0.1	-0.7	-1.9	0.7	-0.7	-0.3	0.0	-0.4	1.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.9	-0.7	-1.6	-2.0	-0.1	-0.9	-0.6	-1.2	-1.0	-0.7	-0.4	-0.3	-0.3	-1.6	-0.5	-1.9	-0.5	0.0	-1.3
Stomach or abdominal pain in last month	0.5	0.7	4.2	0.5	-0.2	0.2	2.0	-0.2	0.7	-0.1	0.9	0.9	0.1	0.6	0.5	-0.7	-0.7	-0.1	1.1	1.6	0.6
Medication: Atenolol	0.5	0.6	2.7	-0.2	0.6	1.6	-0.0	0.6	0.2	0.3	0.2	0.2	0.6	0.4	-0.7	1.4	0.4	0.9	1.0	0.0	1.5
Medication: Ramipril	0.5	0.6	5.1	0.8	-0.1	-0.0	-0.3	0.3	0.1	0.4	0.9	2.3	0.9	0.5	0.3	0.3	0.2	-0.5	1.3	0.8	0.6
Father’s age at death	0.5	0.7	2.1	-0.8	-1.0	-1.0	-1.1	-1.1	-0.7	-0.7	-1.4	-0.7	-1.1	-0.5	-1.0	-0.3	-0.4	-0.4	-0.9	-0.8	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	1.1	-1.3	0.4	1.2	0.3	0.4	-0.4	0.5	0.6	1.3	1.1	-0.1	-0.5	-0.2	-0.9	1.2	1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.6	-0.4	-2.4	-1.0	1.1	-0.4	-1.0	-1.9	-1.0	-1.3	-0.7	-0.4	-1.2	-2.2	-1.9	-2.0	-0.1	0.0	-0.5
Impedance of arm (left)	0.5	2.5	5.3	-1.8	-0.9	-1.0	-0.7	-1.6	-1.8	-1.0	-2.1	-1.8	-2.1	-2.3	-1.9	-0.7	-1.4	-1.0	-2.0	-2.2	-0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	6.8	-0.7	0.3	-1.3	0.2	-0.3	-0.6	0.1	-0.5	-2.6	-0.7	-1.4	-0.0	-0.2	-0.6	-0.3	-1.5	-1.0	-0.8
Gout (self-reported)	0.5	0.6	1.6	0.5	1.2	0.8	-0.5	-0.4	0.9	1.1	0.6	-0.5	0.3	0.6	0.6	1.3	0.9	1.1	0.6	0.4	0.9
Pulse wave peak to peak time	0.5	0.6	2.5	-0.9	0.2	-1.1	-1.6	-1.5	-0.5	-0.4	0.3	0.2	-1.0	-1.2	-0.4	-0.3	-0.7	-0.2	-0.4	-0.6	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	3.0	-0.8	-1.7	0.5	1.1	1.5	-0.6	-1.7	-0.5	-0.2	0.1	-0.4	-1.2	-0.6	-0.9	-1.2	-0.3	-0.5	0.4
Medication: Omeprazole	0.5	0.6	1.5	-1.1	-0.1	-0.5	-0.2	-0.9	-0.6	-0.6	-0.8	-0.2	-1.2	-1.2	-0.8	-0.4	-0.7	-0.2	-1.0	-0.9	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	3.2	-0.0	-1.0	0.1	-1.8	-1.0	-0.5	-0.2	-0.9	-0.6	-0.1	-0.1	-1.5	0.5	-0.4	-0.6	0.7	-0.6	0.9
Suffer from ‘nerves’	0.5	0.9	4.4	-0.7	2.1	-0.5	-0.9	-1.3	0.1	0.7	0.5	-1.2	-0.9	-0.8	0.6	0.8	0.3	1.5	-0.8	-0.2	-0.1
Supplements: Vitamin C	0.5	0.6	1.4	0.0	-1.1	-0.1	-1.1	-0.1	-1.0	-0.9	-1.1	0.2	-0.2	-0.0	-1.2	-0.8	-1.0	-0.7	-0.6	-1.0	-0.4
Average weekly red wine intake	0.5	0.7	4.3	-0.7	0.1	0.5	0.7	2.1	-0.5	-0.4	-0.7	-0.7	0.3	-0.9	-0.3	-0.3	-0.1	-0.3	-1.3	-1.3	-1.3
Ever taken oral contraceptive pill	0.5	0.5	2.6	-0.3	-0.2	1.3	-1.2	1.6	-0.4	-0.1	-0.5	1.5	0.0	-0.1	-0.3	0.4	0.6	0.5	-0.5	-0.4	-0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	3.5	-0.4	-0.3	-0.6	-0.2	-1.4	-0.5	-0.4	-1.1	-1.9	-0.6	-0.3	-0.8	-0.5	-0.6	-0.3	-0.2	-1.0	-0.4
Body Mass Index (BMI) (2010)	0.4	0.6	2.1	-0.3	-1.0	-1.5	-0.7	-1.0	-0.1	-0.6	-0.4	0.6	-0.8	-0.0	0.4	-1.3	-0.5	-1.2	0.1	0.6	-0.5
Crohns Disease (2012)	0.4	0.7	4.5	-0.2	-0.3	-0.8	-0.3	-2.1	-0.3	-0.5	0.1	-1.8	-0.9	0.0	-0.5	-1.0	-1.1	-0.3	0.2	0.4	-0.2
Neuroticism (2016)	0.4	0.6	3.1	-0.6	1.3	0.5	-1.8	0.8	-0.4	0.6	1.3	-0.0	0.1	0.0	0.4	0.7	-0.1	0.6	0.5	0.6	0.6
Rheumatoid Arthritis	0.4	0.5	3.2	-0.5	0.6	-1.0	-1.8	-1.5	-0.1	-0.1	-0.1	-0.6	-1.0	0.0	0.1	0.3	0.5	0.8	-0.4	0.1	-0.2
Ulcerative Colitis	0.4	0.5	6.0	-0.6	0.0	-0.6	0.3	-0.9	-0.5	-0.4	-0.1	-2.5	-0.6	0.0	-0.2	-0.3	-0.7	-0.3	-0.3	-0.2	-0.2
Systolic Blood Pressure	0.4	2.0	11.0	1.5	-1.1	1.4	3.3	2.3	0.6	-0.8	0.6	1.9	1.9	1.4	0.4	-1.0	-0.7	-1.1	1.2	0.5	0.1
Medication: Metformin	0.4	0.6	1.7	-0.5	-1.3	0.2	0.1	0.1	-0.5	-1.0	-0.1	1.1	-1.0	-0.6	-0.9	-1.3	-1.2	-0.7	-0.5	-0.2	-0.6
Severe depression (siblings)	0.4	0.4	1.9	0.2	-0.5	0.4	0.6	1.4	0.2	-0.3	0.7	0.5	0.3	0.6	0.6	-1.2	-0.4	-0.2	0.5	0.7	-0.7
Supplements: Glucosamine	0.4	0.6	1.5	-0.9	0.8	-1.0	-0.6	-0.2	-0.2	0.6	-0.9	-0.7	-0.7	-0.4	0.4	0.4	0.9	0.7	-1.2	-1.0	-0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.0	1.1	-0.4	-0.1	-0.7	0.7	1.0	0.0	0.2	-0.5	0.2	1.2	-0.2	0.7	1.2	-0.5	0.6	-0.8
Waist circumference	0.4	1.4	2.8	-1.1	-1.5	-1.7	-0.8	-1.5	-1.1	-1.5	-1.3	0.1	-1.6	-0.9	-0.8	-1.5	-1.1	-1.2	-0.8	-0.2	-0.9
Hair/balding pattern: Pattern 2	0.4	0.5	2.5	-0.7	0.5	-1.0	0.2	-0.9	-0.0	-0.3	-0.8	-1.6	-0.9	-0.7	0.2	0.0	-0.0	-0.1	-0.8	-0.6	-0.5
Qualifications: None of the above	0.4	0.8	6.6	-0.7	-0.0	0.1	-2.6	-1.1	-1.0	-0.4	-0.7	0.6	-0.9	-0.9	-0.5	-0.3	-0.3	-0.3	-0.3	-0.8	-0.7
Allergy	0.4	1.0	3.9	0.8	1.8	1.6	0.5	0.6	0.7	1.6	0.9	0.2	0.4	0.4	0.4	1.4	0.6	2.0	0.1	-0.3	0.7
Medication: Simvastatin	0.4	0.6	2.8	-0.6	-1.1	-1.0	-0.0	-0.3	-0.3	-1.0	-0.2	0.5	-0.5	-0.3	-0.1	-1.7	-1.0	-1.2	0.2	0.1	-1.1
Impedance of arm (right)	0.4	1.8	3.8	-1.6	-0.7	-0.8	-0.4	-1.4	-1.5	-0.8	-1.7	-1.5	-1.8	-2.0	-1.6	-0.8	-1.4	-0.8	-1.6	-1.7	-0.8
Happiness	0.4	0.4	1.3	0.8	-0.1	-0.3	1.1	0.5	0.6	-0.0	1.1	0.0	0.8	1.0	1.0	0.2	0.9	0.2	0.3	0.8	0.1
Illnesses of mother	0.4	0.5	2.4	-0.7	0.5	0.3	0.1	-0.2	-1.0	0.0	-0.3	-0.4	-0.3	-1.3	-1.0	0.8	-0.4	0.1	-0.5	-1.6	0.0
Pulse wave Arterial Stiffness index	0.4	0.5	2.5	0.8	-0.6	0.8	1.6	1.2	0.2	-0.0	-0.6	-0.5	0.8	1.0	0.2	-0.2	0.3	-0.3	0.2	0.3	0.1
Medication: Paracetamol	0.4	0.7	3.8	0.0	0.3	-1.6	-0.5	-1.9	-0.0	0.4	-0.4	-0.9	-0.9	-0.2	0.7	-0.9	-0.1	-0.2	-0.3	-0.1	-1.4
Glaucoma (self-reported)	0.4	0.4	1.6	-0.3	0.7	0.9	0.7	0.5	0.3	0.4	0.2	-0.8	0.4	-0.3	-0.7	1.3	0.0	0.4	0.5	-0.3	1.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.5	-0.1	-0.1	-1.9	-0.3	-1.3	0.7	-0.0	0.4	-0.4	0.3	0.1	0.5	-0.4	-0.1	-1.0	1.2	0.6	-0.1
Eye problems/disorders: None of the above	0.4	0.4	2.0	1.0	-1.3	-0.5	0.2	0.4	0.2	0.0	0.0	0.2	0.9	0.6	-0.3	0.0	-0.2	-1.4	0.9	-0.2	0.6
Medication: Blood pressure	0.4	0.7	6.2	0.4	-0.1	1.3	-0.0	0.3	0.2	-0.3	0.3	2.5	0.5	0.8	-0.6	0.6	0.2	0.3	1.4	0.3	1.1
Migraine (self-reported)	0.4	0.5	1.6	-0.5	-0.7	-0.7	0.9	-0.5	-0.6	-1.0	-0.3	0.1	-0.3	-0.5	-0.8	-1.0	-1.3	-1.2	0.2	-0.7	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	2.0	-0.3	-0.4	1.3	-0.1	1.4	-0.6	-0.7	-0.5	0.6	-0.3	-0.3	-1.2	-0.1	-0.4	0.6	-1.1	-0.4	-0.2
Heart disease (mother)	0.4	0.5	2.0	0.3	0.7	-0.1	-0.0	-1.4	0.4	0.7	-0.5	-1.4	-0.4	0.4	0.4	-0.0	0.6	0.9	-0.7	-0.3	-0.7
Leg pain on walking	0.4	0.5	1.2	1.0	0.0	1.0	-0.3	0.3	0.4	0.7	0.4	1.0	0.3	1.0	0.7	0.5	1.1	0.6	0.3	1.0	0.5
Loneliness, isolation	0.4	0.5	1.6	-0.2	0.9	0.8	-1.3	1.2	-0.0	0.3	0.8	0.9	0.0	-0.1	0.1	0.8	0.7	1.1	-0.3	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	0.5	0.2	0.6	1.4	0.6	1.2	-0.0	0.8	0.7	0.5	1.0	0.8	-0.5	-0.2	0.1	1.2	0.9	0.3
Breast cancer (self-reported)	0.4	0.5	1.8	-0.6	1.3	-0.6	0.2	-1.0	0.2	0.5	0.2	-1.3	-0.8	-0.9	0.2	-0.1	-0.3	0.6	-0.7	-0.6	-0.9
Guilty feelings	0.4	0.5	2.4	0.5	0.4	1.1	-1.1	1.6	-0.1	0.7	1.0	0.1	0.6	-0.0	0.0	0.7	0.5	0.4	0.7	0.8	0.6
Medication: Bendroflumethiazide	0.4	0.7	1.6	-1.1	-0.0	0.8	0.8	0.6	-0.3	-0.3	-1.1	1.2	-0.7	-0.6	-1.0	-0.7	-0.7	0.2	-0.8	-1.3	-1.0
Ever smoked	0.4	0.8	4.0	0.5	-0.2	2.0	-0.2	1.9	-0.1	0.1	-0.4	-1.0	1.0	0.6	-0.8	1.1	0.6	0.3	0.4	-0.4	1.0
Average weekly beer plus cider intake	0.4	0.5	1.7	1.3	0.2	1.1	0.6	0.9	0.7	0.6	0.5	1.1	1.1	1.0	0.3	0.3	0.3	0.3	0.6	0.2	0.2
Myopia	0.4	0.6	3.1	0.5	-0.7	-0.1	0.7	-0.3	-0.0	-0.3	0.7	-1.8	0.8	0.5	-0.3	-0.1	-0.9	-0.9	1.4	0.7	1.1
Supplements: Calcium	0.4	0.5	2.1	0.1	0.7	1.4	1.1	1.0	0.8	0.5	0.2	-0.4	0.1	0.3	0.0	0.5	0.2	1.4	-0.1	0.4	0.6
Alzheimer’s Disease (in mother)	0.3	0.3	2.0	0.0	-0.4	0.3	-0.8	0.2	0.0	-0.3	-0.8	0.2	-0.5	0.1	-0.2	-0.4	0.2	0.5	-1.4	-0.7	-0.9
Irritable Bowel Disease (IBD)	0.3	0.7	2.3	1.0	-0.0	0.4	1.5	-0.3	0.9	0.5	1.1	0.1	0.6	1.3	0.7	-0.7	-0.4	0.1	1.3	1.5	0.3
Breast Cancer	0.3	0.8	2.4	0.8	-0.5	0.9	-1.5	0.1	0.3	0.0	0.3	1.4	0.2	1.4	0.2	0.2	0.6	0.5	1.3	1.5	1.2
Ovarian Cancer	0.3	0.4	1.7	0.2	-0.6	0.5	-0.2	1.3	-0.1	-0.2	0.1	1.3	0.4	0.6	-0.2	0.6	0.4	0.1	0.3	0.6	1.2
Mean Putamen Volume	0.3	0.3	1.3	-0.0	-0.5	-0.0	1.1	0.2	-0.2	-0.3	-0.7	-0.9	-0.0	0.0	-0.2	-0.9	-0.8	-0.8	0.2	-0.6	-0.7
LDL Cholesterol	0.3	0.5	2.5	0.6	0.7	0.6	1.6	0.0	1.3	1.4	0.1	-0.4	0.0	0.0	0.8	-0.3	-0.0	0.7	0.3	0.3	-0.6
Number of treatments/medications taken	0.3	0.5	1.1	0.4	1.1	0.9	-0.1	0.2	0.8	0.8	0.3	1.0	0.4	0.7	0.8	0.8	0.8	0.9	0.9	0.5	0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	-0.1	0.7	0.4	1.1	1.3	0.7	0.2	0.0	1.0	-0.0	-0.1	0.7	0.4	0.6	0.4	-0.3	-0.1	-0.3
Systolic blood pressure, automated reading	0.3	0.9	4.1	1.0	-0.2	0.7	2.0	1.1	0.9	0.0	0.5	1.0	1.5	1.0	0.8	-0.6	-0.2	-0.7	1.2	0.5	-0.1
Supplements: Zinc	0.3	0.3	1.1	0.4	0.3	-0.3	0.6	0.6	0.6	0.8	0.5	-1.1	0.9	0.3	0.3	0.3	0.1	-0.1	0.8	0.6	0.5
Medication: Co-codamol	0.3	0.3	2.4	-0.8	0.1	-0.1	-1.1	-0.2	-0.3	-0.5	-0.0	1.6	-0.5	-0.6	0.3	-0.1	0.2	0.1	-0.6	0.2	-0.3
Taking other prescription medications	0.3	0.4	1.6	0.2	0.8	1.3	0.8	0.5	1.0	0.4	0.6	0.5	0.4	0.2	0.3	0.7	0.1	0.6	0.9	0.3	0.8
High blood pressure (mother)	0.3	0.5	2.0	0.3	-1.3	-0.2	0.1	0.6	-0.2	-0.9	-0.4	1.1	-0.0	0.5	-0.1	-1.4	-0.7	-1.0	0.0	0.4	-0.4
Nervous feelings	0.3	0.6	2.4	-0.1	1.6	-0.2	-0.5	0.1	-0.1	0.9	1.0	-1.0	0.3	-0.1	1.2	1.2	0.8	1.0	-0.1	0.6	0.8
Had menopause	0.3	0.4	1.7	-0.3	0.5	0.5	1.3	0.3	0.9	0.4	-0.9	-0.3	0.3	0.4	0.1	0.8	0.7	0.3	0.0	-0.8	0.1
Had other major operations	0.3	0.3	1.2	0.1	1.0	0.4	0.4	-1.1	0.6	0.7	-0.2	-1.1	-0.4	-0.1	0.0	0.5	0.1	0.9	-0.0	-0.3	-0.1
Diabetes (self-reported)	0.3	0.5	2.1	-0.3	-1.4	-0.7	0.7	-0.3	-0.2	-0.7	-0.2	0.2	-0.4	-0.1	-0.5	-1.4	-1.0	-1.0	-0.1	0.2	-0.6
Neuroticism score	0.3	0.6	3.3	-0.5	1.8	0.1	-1.5	0.1	-0.3	0.8	1.1	-0.3	-0.4	-0.9	0.8	0.5	0.3	1.2	-0.5	0.2	-0.3
Pulse rate	0.3	0.6	3.9	-0.4	0.5	0.1	-2.0	-0.5	-1.0	-0.1	-0.5	-0.9	-0.7	-0.3	-0.3	0.1	0.1	1.2	-1.1	-0.4	-0.5
Medication: Cholesterol lowering	0.3	0.5	3.1	0.3	-0.5	0.4	0.6	0.3	0.7	-0.3	0.6	1.8	0.4	0.9	0.3	-0.6	0.1	0.0	1.0	1.1	-0.0
Trunk predicted mass	0.3	1.5	5.2	-0.9	-2.0	-0.8	0.3	0.1	-1.1	-2.3	-0.6	0.3	-0.8	-0.8	-1.3	-1.9	-1.9	-1.9	-0.2	-0.1	-0.7
Birth weight of first child	0.3	0.5	1.3	0.1	-1.2	-0.0	1.0	0.2	-0.6	-0.6	-0.6	0.0	-0.5	-0.3	-0.4	-1.1	-0.9	-0.8	-1.0	-0.2	-0.8
Pulse wave reflection index	0.3	0.4	2.0	-0.2	-1.2	-0.7	1.1	0.1	-0.2	-0.7	-0.8	-0.9	0.2	-0.2	-0.4	-0.3	-0.3	-1.4	-0.0	-0.2	0.1
Leg fat percentage (right)	0.3	1.0	3.0	-1.0	-0.6	-1.5	-1.0	-1.7	-0.6	-0.4	-1.6	-0.5	-1.5	-0.9	-0.3	-0.7	-0.2	-0.7	-0.9	-0.8	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	2.0	-0.5	-0.1	-0.9	-1.4	-1.0	-0.5	-0.2	-0.6	-1.0	-1.1	-0.2	0.1	-0.2	0.4	0.1	-0.1	0.3	-0.2
Health satisfaction	0.3	0.4	1.7	0.0	0.6	-0.4	-0.5	-0.5	0.1	0.3	0.7	1.3	-0.2	0.1	0.4	1.2	1.3	0.7	0.1	0.3	0.5
Comparative height size at age 10	0.3	1.8	6.0	-0.9	-2.4	-0.7	0.9	-0.3	-0.9	-2.3	-1.0	0.1	-0.9	-0.7	-1.3	-2.0	-2.0	-2.2	0.1	-0.3	-0.4
Ever had bowel cancer screening	0.3	0.4	1.0	-0.1	-0.4	-0.9	0.8	-1.0	0.9	-0.2	0.1	0.9	-0.2	0.6	1.0	-0.8	0.1	-0.4	0.5	0.6	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	-0.2	-0.7	0.3	0.2	0.4	-0.6	-0.9	-0.3	0.7	-0.7	-0.5	-1.1	-0.6	-0.9	-0.2	-0.7	-0.9	-0.4
Commuting to job workplace: Public transport	0.3	0.3	1.7	-0.4	-0.4	-0.8	-0.6	-0.5	-0.2	-0.5	-0.7	-1.3	-0.5	-0.1	0.0	-0.0	0.2	-0.3	-0.8	-0.5	-0.3
Medication: Paracetamol	0.3	0.5	3.3	-0.1	0.1	-1.3	-1.2	-1.8	-0.3	0.0	-0.5	-0.3	-0.8	-0.2	0.2	-0.6	-0.2	-0.3	0.0	-0.3	-0.7
Leg fat percentage (left)	0.3	1.0	3.2	-1.0	-0.6	-1.5	-1.0	-1.8	-0.6	-0.3	-1.6	-0.4	-1.4	-0.8	-0.2	-0.8	-0.2	-0.7	-0.9	-0.7	-1.1
Prostate Cancer	0.2	0.2	1.0	0.1	-0.0	0.8	0.1	-0.8	-0.0	-0.2	-0.6	-0.6	-0.4	-0.2	-1.0	-0.1	-0.6	0.1	-0.4	-0.5	-0.0
Fasting Glucose	0.2	0.2	0.7	-0.2	0.8	-0.2	-0.2	0.0	0.2	0.7	0.4	-0.8	0.3	-0.3	-0.1	0.4	-0.4	-0.6	0.5	-0.0	0.8
Pack years adult smoking proportion	0.2	0.3	2.4	0.3	-0.1	1.5	-0.1	1.0	-0.2	-0.2	0.1	1.6	0.0	0.2	-0.2	0.1	-0.0	0.4	-0.2	-0.1	0.2
Trunk fat percentage	0.2	0.7	3.8	-0.9	-0.2	-0.9	-1.3	-1.9	-0.5	-0.2	-0.9	-0.8	-1.5	-1.0	-0.3	-0.2	-0.2	-0.1	-0.7	-0.1	-0.2
Fed-up feelings	0.2	0.4	1.7	-0.5	0.5	-0.1	-1.3	0.2	-1.0	-0.3	0.5	0.3	-0.7	-0.8	-0.1	-0.0	-0.3	0.6	-1.0	0.2	-0.2
Age when periods started (menarche)	0.2	0.6	1.9	-1.4	1.3	-0.4	-0.7	0.4	-0.3	0.1	0.1	-0.3	-0.8	-1.3	0.5	0.2	0.2	0.7	-1.2	-0.5	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.8	0.0	0.6	0.0	0.0	-0.0	0.3	0.8	-0.9	0.3	-0.2	0.1	0.5	0.2	0.8	0.5	-0.5	-0.9	-0.7
Trunk fat mass	0.2	1.0	3.2	-1.1	-0.8	-1.1	-1.2	-1.8	-0.9	-0.9	-1.0	-0.4	-1.7	-1.1	-0.7	-0.8	-0.8	-0.6	-0.8	-0.1	-0.4
Past tobacco smoking	0.2	0.5	1.7	0.1	0.5	-1.3	0.3	-1.0	0.5	0.4	0.9	1.1	-0.1	0.2	1.2	-0.3	0.2	0.1	0.2	0.9	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.2	0.7	0.1	0.4	0.3	0.6	0.2	1.0	-0.3	0.2	0.4	0.8	0.0	0.4	0.6	0.5	1.1	0.1
Trunk fat-free mass	0.2	1.4	4.9	-0.9	-1.9	-0.7	0.3	0.2	-1.1	-2.2	-0.5	0.4	-0.6	-0.7	-1.2	-1.8	-1.8	-1.9	-0.1	-0.1	-0.7
Hip circumference	0.2	0.8	2.5	-1.2	-0.2	-0.8	-1.0	-1.3	-0.7	-0.8	-1.0	-0.8	-1.6	-0.9	-0.7	-0.4	-0.3	0.2	-1.1	-0.4	-0.7
Worrier / anxious feelings	0.2	0.4	1.8	-0.1	1.3	0.1	0.1	-0.1	0.1	0.6	1.0	-1.2	-0.0	-0.1	1.0	-0.3	-0.2	1.0	-0.1	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.4	1.9	0.5	0.1	0.8	0.5	1.0	0.8	0.3	0.5	1.4	0.4	0.6	0.3	0.5	0.5	0.4	0.6	0.3	0.7
High blood pressure (siblings)	0.2	0.4	1.1	0.2	0.2	-0.5	-0.0	-0.9	0.8	0.1	0.3	0.6	0.2	1.0	1.0	-0.9	-0.1	0.4	0.4	1.0	-0.4
Body fat percentage	0.2	0.9	4.0	-1.0	-0.4	-1.1	-1.2	-2.0	-0.6	-0.4	-1.2	-0.6	-1.7	-0.9	-0.3	-0.4	-0.2	-0.2	-0.9	-0.3	-0.6
Medication: Allopurinol	0.2	0.3	0.9	-0.3	0.5	0.2	-0.9	-0.7	0.1	0.2	-0.2	-0.9	-0.1	0.0	-0.5	1.0	0.2	0.5	0.1	-0.4	0.7
Whole body fat mass	0.2	0.8	2.7	-0.9	-0.7	-1.1	-1.0	-1.6	-0.7	-0.9	-1.0	-0.4	-1.6	-0.9	-0.5	-0.8	-0.6	-0.5	-0.8	-0.1	-0.6
Leg fat mass (right)	0.2	0.7	1.7	-0.8	-0.9	-1.2	-0.7	-1.2	-0.7	-0.9	-1.0	0.1	-1.3	-0.7	-0.4	-0.8	-0.4	-0.7	-0.7	-0.1	-0.7
Alcohol intake frequency.	0.2	0.6	1.8	-0.4	-0.7	-0.9	-0.7	-1.3	-1.1	-0.6	-0.3	-0.8	-0.9	-0.8	-1.0	-0.1	-0.8	-0.9	0.3	-0.1	0.5
Family relationship satisfaction	0.2	0.3	1.1	-0.6	-0.2	-0.3	-0.5	-0.3	-0.5	-0.5	-0.5	-0.3	-0.7	-0.7	-0.2	-0.0	0.0	-0.2	-0.7	-1.1	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	0.1	-1.0	-0.2	0.5	-0.3	0.3	-0.6	0.2	0.5	0.2	0.2	-0.4	-0.8	-0.6	-0.7	0.6	0.5	0.0
Long-standing illness, disability or infirmity	0.2	0.3	1.2	-1.0	1.1	0.1	0.3	0.6	-0.1	0.2	0.1	-0.1	-0.6	-0.9	0.3	0.4	0.0	0.6	-0.4	-0.4	-0.4
Diabetes diagnosed by doctor	0.2	0.3	1.5	0.0	-0.9	-0.2	1.2	0.2	-0.1	-0.3	0.3	0.7	0.1	-0.0	-0.2	-1.1	-1.0	-0.7	0.1	0.5	-0.3
Friendships satisfaction	0.2	0.3	1.2	-0.4	-0.1	-0.9	-0.3	-0.4	-0.2	-0.6	0.0	-1.0	-0.3	0.2	0.4	-1.0	-0.2	-0.1	-0.3	-0.2	-1.1
Eye problems/disorders: Cataract	0.2	0.3	0.8	-0.8	-0.2	-0.0	-0.8	-0.4	-0.8	-0.7	-0.1	-0.0	-0.6	-0.9	-0.3	-0.2	-0.2	-0.3	-0.6	0.3	-0.1
Osteoporosis (self-reported)	0.2	0.2	1.2	0.3	-0.0	0.9	-0.1	1.1	0.1	0.3	0.5	0.6	0.1	0.1	0.2	0.1	0.1	0.3	0.5	0.9	0.6
Medication: Aspirin	0.2	0.3	1.0	-0.0	0.7	-0.8	-0.1	-1.0	0.4	0.5	0.9	0.5	0.2	0.4	0.7	0.1	0.1	0.3	0.6	0.6	-0.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.7	0.5	0.9	0.5	0.6	0.0	-0.3	-0.1	-0.3	-0.0	-0.3	-0.7	0.7	-0.2	0.5	0.0	-0.2	0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.6	-0.6	0.2	-0.1	-0.5	0.2	-0.4	0.0	-0.1	1.3	-0.4	-0.4	0.6	0.3	0.6	0.2	-0.6	-0.1	-0.3
Irritability	0.2	0.3	1.6	-0.2	0.6	1.3	-0.2	0.5	0.0	-0.0	0.9	0.7	-0.4	-0.5	-0.1	-0.5	-0.8	0.8	-0.3	0.3	-0.2
Diastolic blood pressure, automated reading	0.2	0.7	2.5	1.6	0.2	0.2	0.8	0.5	1.0	0.4	0.5	0.9	0.9	1.4	1.4	-0.5	0.7	-0.0	0.7	0.8	-0.5
Pack years of smoking	0.2	0.3	1.9	-0.3	0.1	1.2	-0.3	0.7	-0.5	-0.3	-0.4	1.4	-0.3	-0.2	-0.4	0.1	-0.1	0.3	-0.7	-0.8	-0.2
Ulcerative Colitis (UC)	0.1	0.2	1.4	0.2	-0.1	0.3	1.2	0.3	0.1	-0.1	0.6	0.1	0.2	0.3	0.1	-0.3	-0.4	-0.2	0.4	0.5	0.2
Triglycerides	0.1	0.2	1.0	0.0	-0.1	-0.6	0.2	-0.7	0.3	0.1	-0.4	0.6	-0.4	0.0	0.6	-0.7	0.0	-0.2	-0.4	-0.0	-1.0
Heel T-Score	0.1	0.4	2.2	0.8	-0.2	-0.7	-0.1	-0.1	-0.1	0.9	-0.7	-1.5	0.0	-0.2	-0.1	-0.5	0.1	-0.8	0.0	-0.6	-1.2
BMI	0.1	0.8	3.2	0.7	0.5	0.3	0.7	0.2	1.1	0.5	1.3	1.2	0.5	0.9	1.0	0.3	0.6	0.7	1.2	1.8	0.8
Lung FVC	0.1	0.5	2.5	0.8	-0.8	1.2	1.3	1.6	-0.1	-0.5	-0.2	0.5	0.8	0.7	-0.5	-0.5	-0.4	-0.4	0.5	-0.1	-0.0
Hair Pigment	0.1	3.2	7.5	1.6	2.2	1.8	0.3	1.1	2.3	2.7	2.0	0.4	1.9	1.6	2.0	1.9	2.2	2.1	1.3	1.6	1.2
Hand grip strength (left)	0.1	0.3	1.5	0.2	-0.8	-0.5	-1.2	0.0	-0.5	-0.7	-0.4	1.0	-0.0	0.3	-0.3	-0.1	0.2	-0.4	0.1	0.2	0.1
Leg fat-free mass (left)	0.1	0.4	1.8	0.1	-0.9	-0.1	0.3	0.3	-0.2	-1.1	0.7	0.8	-0.1	-0.0	-0.3	-0.5	-0.7	-0.6	0.5	1.3	0.7
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.5	-0.1	0.2	-0.3	-0.2	0.0	0.2	-0.2	0.4	0.3	0.4	0.3	0.3	0.4	-0.3	0.4	-0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.7	0.4	-0.1	-0.5	0.3	-0.4	0.1	0.0	0.4	-0.3	0.0	0.0	0.5	0.2	-0.2	-0.4	0.5	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.6	-0.6	-0.3	0.8	-0.0	-0.1	0.3	-0.1	-0.4	-0.1	-0.3	-0.6	-0.1	-0.3	-0.7	-0.3	-0.3	-0.1
Body mass index (BMI)	0.1	0.3	1.3	0.5	0.3	-0.3	-0.5	-0.9	0.5	0.3	0.5	0.1	0.0	0.6	0.6	0.5	0.7	0.5	0.5	1.1	0.5
Leg predicted mass (left)	0.1	0.4	2.0	0.2	-0.8	-0.0	0.4	0.3	-0.0	-1.0	0.9	0.7	0.0	0.1	-0.2	-0.4	-0.6	-0.5	0.6	1.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.2	0.3	-0.2	-0.6	0.4	-0.6	-0.2	0.4	-0.4	-1.1	-0.4	-0.6	-0.6	-0.2	-0.1	-0.2	-1.0	-0.8	-0.8
Weight	0.1	0.7	2.0	-0.8	-1.2	-1.0	-0.3	-1.0	-0.8	-1.4	-0.6	0.0	-1.1	-0.7	-0.7	-1.1	-1.0	-1.0	-0.4	0.2	-0.5
Arm fat percentage (right)	0.1	0.4	3.3	-0.4	0.1	-0.9	-1.1	-1.8	-0.1	0.0	-0.3	-0.3	-1.0	-0.2	0.1	0.1	0.3	0.3	-0.3	0.4	0.0
Noisy workplace	0.1	0.1	0.3	0.2	-0.3	-0.4	-0.5	-0.0	-0.4	-0.2	0.3	-0.4	0.1	0.2	0.0	-0.4	-0.3	0.1	0.0	0.5	-0.2
Lung cancer (father)	0.1	0.1	0.5	0.2	0.5	-0.1	-0.1	0.0	-0.1	0.5	0.6	0.6	0.4	-0.1	0.7	0.4	0.3	-0.1	0.2	0.3	0.1
Arm fat mass (right)	0.1	0.3	2.0	-0.4	-0.5	-0.8	-0.5	-1.4	-0.3	-0.6	-0.3	-0.4	-0.9	-0.3	-0.3	-0.4	-0.3	-0.3	-0.1	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	-0.1	0.7	-0.6	0.2	-0.7	0.3	0.7	0.1	0.2	0.1	0.0	0.6	0.2	0.5	0.3	-0.0	-0.2	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.6	-0.5	-0.1	0.0	-0.5	-0.2	-0.5	-0.6	-0.1	0.3	-0.7	-0.7	-0.5	-0.1	-0.4	-0.2	-0.1	0.1	0.4
Arm fat-free mass (right)	0.1	0.7	3.0	-0.5	-1.6	-0.5	0.1	0.2	-0.8	-1.7	-0.2	0.3	-0.5	-0.5	-0.9	-1.2	-1.3	-1.5	0.2	0.3	-0.1
Comparative body size at age 10	0.1	0.4	1.3	1.2	-1.1	0.7	-0.5	0.5	0.0	-0.3	0.1	0.7	0.7	0.6	-0.5	0.3	0.4	-0.1	0.4	0.6	1.0
Number of full brothers	0.1	0.2	0.9	0.2	0.0	-0.4	-0.0	0.3	0.3	0.3	0.2	1.0	0.3	0.0	0.9	-0.1	0.2	-0.6	0.2	0.0	-0.2
Qualifications: College or University degree	0.1	0.2	1.1	-0.2	-0.7	-1.1	-0.2	-0.2	-0.3	-0.4	-0.3	-0.1	0.3	0.1	-0.1	-0.1	-0.3	-0.9	0.2	0.0	0.4
Arm predicted mass (right)	0.1	0.6	2.5	-0.4	-1.4	-0.3	0.2	0.3	-0.5	-1.6	-0.2	0.5	-0.4	-0.3	-0.7	-1.2	-1.0	-1.3	0.2	0.3	-0.2
Pulse rate, automated reading	0.1	0.2	1.5	0.1	0.7	0.3	-0.5	-0.1	-0.4	0.0	0.2	-1.2	-0.4	-0.3	0.2	-0.2	-0.2	0.8	-0.4	0.2	-0.3
Medication: Aspirin	0.1	0.2	1.0	-0.1	0.7	-0.8	-0.1	-1.0	0.3	0.5	0.5	0.2	0.1	0.1	0.4	0.0	0.0	0.2	0.4	0.2	-0.4
Smoking status: Previous	0.1	0.2	1.2	0.5	0.4	1.1	-0.3	0.6	0.5	0.6	-0.1	-0.4	0.3	0.5	0.1	0.4	0.5	0.8	0.0	-0.1	-0.0
Whole body fat-free mass	0.1	0.7	3.0	-0.5	-1.4	-0.4	0.3	0.3	-0.7	-1.7	0.0	0.6	-0.4	-0.5	-0.8	-1.2	-1.4	-1.3	0.2	0.5	-0.1
Leg fat-free mass (right)	0.1	0.5	2.5	0.4	-0.9	0.1	0.3	0.4	-0.0	-1.0	1.0	0.8	0.2	0.2	-0.1	-0.4	-0.6	-0.6	0.7	1.6	0.9
Arm fat percentage (left)	0.1	0.5	3.6	-0.6	-0.1	-1.1	-1.2	-1.9	-0.3	-0.2	-0.5	-0.6	-1.2	-0.5	-0.1	0.1	0.1	0.1	-0.5	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	0.3	-0.5	-0.5	0.1	-0.2	0.2	-0.2	0.3	0.9	0.1	0.9	0.6	-0.4	0.2	-0.1	0.6	0.9	0.3
Whole body water mass	0.1	0.7	2.9	-0.5	-1.4	-0.4	0.2	0.1	-0.6	-1.7	0.1	0.5	-0.5	-0.5	-0.8	-1.2	-1.3	-1.3	0.2	0.5	-0.0
Leg predicted mass (right)	0.1	0.5	2.6	0.5	-0.8	0.2	0.4	0.6	0.0	-0.9	1.1	0.9	0.3	0.3	-0.1	-0.3	-0.5	-0.5	0.8	1.6	0.9
Arm fat mass (left)	0.1	0.3	2.1	-0.4	-0.5	-0.9	-0.7	-1.5	-0.3	-0.6	-0.3	-0.5	-0.9	-0.3	-0.3	-0.3	-0.2	-0.3	-0.1	0.5	0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	0.3	0.3	0.8	0.4	-0.2	0.6	0.5	0.0	0.7	0.4	0.5	0.0	0.7	0.2	0.1	0.8	-0.1	0.8
Basal metabolic rate	0.1	0.8	3.1	-0.5	-1.5	-0.6	0.1	-0.1	-0.7	-1.8	-0.1	0.3	-0.6	-0.5	-0.9	-1.3	-1.3	-1.4	0.1	0.5	-0.2
Arm fat-free mass (left)	0.1	0.5	2.0	-0.4	-1.2	-0.6	0.2	-0.0	-0.5	-1.4	-0.1	0.3	-0.3	-0.3	-0.5	-1.1	-1.0	-1.3	0.3	0.4	-0.2
Number of operations (self-reported)	0.1	0.1	0.3	0.4	-0.3	0.6	0.5	-0.3	0.1	0.1	-0.5	0.4	-0.2	0.3	-0.1	0.3	0.2	-0.0	0.5	0.2	0.6
Ever depressed for a whole week	0.1	0.1	0.6	-0.2	-0.4	0.4	-0.2	-0.1	-0.2	-0.6	-0.3	0.6	-0.3	-0.1	-0.6	0.3	-0.1	0.1	0.3	-0.0	0.8
Unable to work because of sickness or disability	0.1	0.2	0.9	-0.4	0.6	0.2	0.6	0.1	0.3	-0.0	0.4	0.7	-0.2	0.0	0.1	0.5	0.2	1.0	-0.1	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.3	-0.3	-0.2	0.2	-0.6	-0.0	-0.3	-0.4	-0.2	-0.2	-0.4	-0.6	0.2	-0.3	-0.5	0.2	-0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.5	-0.5	0.1	0.0	-0.4	-0.3	-0.3	-0.4	-0.0	0.2	-0.6	-0.7	-0.4	0.2	-0.1	-0.0	-0.0	0.2	0.5
Leg fat mass (left)	0.1	0.5	1.3	-0.6	-0.8	-1.1	-0.7	-1.1	-0.5	-0.6	-0.8	0.1	-1.1	-0.5	-0.2	-0.8	-0.3	-0.6	-0.6	0.0	-0.7
Arm predicted mass (left)	0.1	0.5	2.2	-0.6	-1.1	-0.5	0.0	-0.1	-0.5	-1.5	-0.2	0.6	-0.4	-0.3	-0.7	-1.1	-1.0	-1.1	0.2	0.2	-0.3
Tanning	0.0	0.2	3.0	-0.1	0.1	0.5	-1.7	-0.1	-0.1	-0.2	-0.3	-0.1	-0.2	-0.2	-0.5	0.1	0.1	0.8	-0.1	-0.2	0.2

Hub : Genes

PIGO

Models

Trait associations