TWAS hub - RNASEH2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.207	0.078	0.0065	-0.008	NA	-0.004	NA	-0.008	8.4e-01	NA	4.7e-01	NA	8.5e-01
2	GTEx	Testis	0.153	0.064	0.0033	0.164	NA	0.130	NA	0.138	9.9e-08	NA	2.2e-06	NA	1.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Age at first live birth	5.3	9.4	9.9	-3.1	3.0
Pain experienced in last month	5.0	8.3	15.9	-4.0	0.9
Hearing difficulty/problems: Yes	3.9	5.9	11.3	3.4	-0.8
Had major operations	3.7	4.3	8.5	0.3	2.9
Qualifications: nursing, teaching	3.5	5.5	11.0	-3.3	-0.1
Noisy workplace	3.4	4.2	7.2	1.1	-2.7
Hearing difficulty/problems with background noise	3.2	5.1	10.0	3.2	-0.5
Lung cancer (father)	3.0	3.6	6.7	2.6	0.6
Osteoporosis (self-reported)	3.0	3.7	4.8	1.7	2.2
Ulcerative Colitis	2.9	4.2	7.0	2.6	-1.2
Stomach or abdominal pain in last month	2.6	3.2	6.1	2.5	0.5
Loneliness, isolation	2.6	3.6	4.9	1.5	2.2
Had other major operations	2.5	3.0	4.0	2.0	-1.4
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	5.8	0.7	-2.4
Age at last live birth	2.5	3.6	5.0	-1.5	2.2
Breast cancer (self-reported)	2.5	2.9	4.6	1.1	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	9.1	3.0	-1.4
Medication: Metformin	2.3	3.2	5.3	-2.3	1.0
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	4.9	-0.3	-2.2
Health satisfaction	2.2	2.8	3.2	1.6	-1.8
Ever taken oral contraceptive pill	2.2	2.5	3.9	1.0	-2.0
Alcohol drinker status: Never	2.2	2.6	3.2	1.4	-1.8
Townsend deprivation index at recruitment	2.1	3.0	5.3	2.3	0.8
Qualifications: None of the above	2.1	4.5	8.9	3.0	0.0
Heel T-Score	2.0	15.8	16.8	4.1	-3.9
Number of incorrect matches in round	2.0	3.3	3.9	-2.0	-1.6
Falls in the last year	2.0	2.7	3.4	1.9	1.4
Breastfed as a baby	2.0	2.5	2.8	1.7	1.5
Peak expiratory flow (PEF)	2.0	4.7	6.9	2.6	-1.6
Blood Platelet Count	1.9	22.5	30.6	-5.5	3.8
High blood pressure (mother)	1.9	2.6	5.0	0.6	-2.2
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.8	1.9	-0.7
Illnesses of father: None of the above (group 1)	1.9	2.3	3.7	-1.9	1.0
Guilty feelings	1.9	2.8	5.5	2.3	0.3
Alzheimer’s Disease (in mother)	1.8	2.1	3.0	-1.1	1.7
Neck or shoulder pain in last month	1.8	2.5	4.1	2.0	-0.9
Knee pain experienced in last month	1.8	2.8	5.6	2.4	0.1
Financial situation satisfaction	1.8	2.3	2.4	1.4	-1.6
Chest pain or discomfort	1.7	2.4	3.2	1.8	-1.3
Medication: Aspirin	1.7	2.2	2.6	-1.4	1.6
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.1	2.0	-0.2
Irritability	1.7	2.9	5.6	0.4	2.4
Alzheimer’s Disease (in father)	1.6	1.8	2.6	1.6	-1.0
Medication: Ibuprofen	1.6	1.9	2.3	1.5	1.2
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.6	-1.9	-0.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	2.6	1.1	-1.6
Average weekly fortified wine intake	1.5	1.8	3.6	-1.9	0.1
Chronic bronchitis/emphysema (father)	1.5	1.8	2.1	1.2	-1.4
Financial difficulties in last 2 years	1.5	2.0	2.1	1.4	-1.4
Eye problems/disorders: None of the above	1.5	1.7	3.3	-1.8	0.4
Hearing aid user	1.5	1.6	3.2	-0.3	-1.8
Verbal and Numeric Reasoning (VNR)	1.4	3.4	5.1	-2.3	1.3
LDL Cholesterol	1.4	2.2	4.1	2.0	0.5
Sensitivity / hurt feelings	1.4	2.4	2.8	1.7	-1.4
Taking other prescription medications	1.4	2.2	3.6	-1.9	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.3	6.4	2.5	-0.4
Qualifications: A levels/AS levels or equivalent	1.4	3.2	5.3	-2.3	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	2.1	1.1	-1.4
Average weekly champagne plus white wine intake	1.4	1.9	3.6	-0.4	1.9
Medication: Lisinopril	1.4	1.8	3.6	0.2	-1.9
Intelligence (Savage-Jansen 2018)	1.3	3.9	5.7	-2.4	1.5
Age when periods started (menarche)	1.3	3.2	4.8	-1.3	2.2
Multivitamins +/- minerals	1.3	1.6	1.8	1.2	1.4
Medication: Ramipril	1.3	1.6	2.8	-0.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	4.4	2.1	0.0
Crohns Disease (2012)	1.2	2.0	3.2	0.9	-1.8
Primary Biliary Cirrhosis	1.2	1.7	2.9	-0.6	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.8	1.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.8	1.7	0.6
Ever depressed for a whole week	1.2	1.5	2.9	-0.4	-1.7
Age at First Birth	1.1	1.6	2.2	-1.0	-1.5
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.1	1.8	0.3
Medication: Atenolol	1.1	1.3	2.6	-0.2	1.6
Alcohol usually taken with meals	1.1	1.8	1.8	-1.3	1.3
Fluid intelligence score	1.1	2.2	4.2	-2.0	-0.5
Medication: Aspirin	1.1	1.5	1.5	-1.2	1.2
Supplements: Vitamin C	1.1	1.4	2.2	0.7	1.5
Back pain experienced in last month	1.1	1.5	1.9	1.1	-1.4
Miserableness	1.1	1.9	3.6	0.4	1.9
Breast Cancer	1.0	2.5	4.9	-2.2	0.4
HbA1C	1.0	1.1	2.0	0.4	-1.4
Number of treatments/medications taken	1.0	1.8	2.1	-1.2	1.4
Ever had hysterectomy (womb removed)	1.0	1.2	2.2	-0.5	1.5
Medication: Co-codamol	1.0	1.2	1.5	-1.2	0.9
Hip circumference	1.0	4.1	4.7	-1.9	2.2
Father’s age at death	1.0	1.3	2.2	-0.6	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.2	1.5	0.3
Standing height	1.0	10.0	15.3	-3.9	2.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.4	1.4	1.2	1.1
Pulse wave peak to peak time	1.0	1.1	2.1	-1.5	-0.3
Emphysema/chronic bronchitis	1.0	1.1	2.2	0.2	1.5
Heart disease (mother)	1.0	1.2	2.1	1.4	-0.6
Diabetes (father)	0.9	1.1	1.9	1.4	-0.6
Sitting height	0.9	6.7	10.2	-3.2	1.8
Diabetes (self-reported)	0.9	1.4	2.6	-1.6	0.4
Pulse wave reflection index	0.9	1.1	1.2	1.1	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	1.5	-0.3
Headache pain in last month	0.9	1.6	2.6	1.6	-0.7
Glaucoma (self-reported)	0.9	1.1	1.4	-0.9	1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.1	-0.9	-1.1
Asthma (self-reported)	0.9	1.8	3.3	-1.8	-0.6
Number of operations (self-reported)	0.9	1.3	1.5	1.2	1.1
Allergy or Eczema	0.8	2.2	4.3	-2.1	0.2
Average weekly spirits intake	0.8	0.9	1.4	0.7	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.3	-1.1	-1.0
Trunk fat-free mass	0.8	4.9	6.2	-1.9	2.5
Asthma	0.8	1.5	3.0	-1.7	-0.3
Medication: Lansoprazole	0.8	0.9	1.0	-1.0	-0.9
Trunk predicted mass	0.8	4.7	6.3	-1.8	2.5
Length of working week for main job	0.8	0.8	1.5	1.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.7	-1.6	-0.1
Worry too long after embarrassment	0.8	1.3	2.6	1.6	-0.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	0.5	-1.3
Ever had bowel cancer screening	0.8	0.9	1.8	0.1	1.3
Medication: Bendroflumethiazide	0.8	1.2	1.5	-1.2	1.0
Average weekly beer plus cider intake	0.8	1.2	2.3	1.5	0.1
Major Depression (MDD)	0.7	0.9	1.6	-0.4	-1.3
BMI	0.7	3.9	4.7	-1.8	2.2
Systolic Blood Pressure	0.7	3.5	6.6	-2.6	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.4	-1.6	0.4
Hand grip strength (left)	0.7	1.8	3.4	0.3	-1.9
Supplements: Zinc	0.7	0.7	1.4	1.2	0.2
Relative age voice broke	0.7	1.1	2.2	-1.5	-0.1
Impedance of leg (left)	0.7	3.2	3.8	-1.6	-1.9
Hair/balding pattern: Pattern 3	0.7	1.0	1.3	1.1	-0.9
Exposure to tobacco smoke outside home	0.7	1.0	1.9	-1.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	1.3	-1.2	-0.8
Number of full sisters	0.7	0.9	1.2	0.7	1.1
Diabetes diagnosed by doctor	0.7	1.1	2.1	-1.4	-0.4
Whole body water mass	0.7	3.8	6.1	-1.3	2.5
Ever smoked	0.7	1.3	1.3	-1.1	1.2
Depressed Affect (Nagel 2018)	0.6	1.4	1.8	1.0	1.3
Fasting Glucose	0.6	0.7	0.8	-0.8	0.9
Triglycerides	0.6	1.0	1.2	1.1	-1.0
Diabetes (mother)	0.6	0.7	1.1	-1.0	-0.6
Severe depression (siblings)	0.6	0.7	1.2	1.1	0.4
Impedance of leg (right)	0.6	3.0	3.8	-2.0	-1.4
Leg fat-free mass (left)	0.6	3.0	5.6	-0.6	2.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	-0.0	1.1
Past tobacco smoking	0.6	1.1	1.3	0.9	-1.1
Pain all over the body in last month	0.6	0.7	1.3	1.1	-0.3
Neuroticism score	0.6	1.2	2.3	1.5	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.9	0.3	1.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.0	1.0	0.6
Hair/balding pattern: Pattern 4	0.6	1.6	2.7	-0.7	1.6
Arm fat-free mass (right)	0.6	2.9	3.8	-1.4	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-0.4	1.1
Alcohol intake frequency.	0.6	1.3	2.4	1.6	-0.5
Leg pain on walking	0.6	0.8	1.4	1.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	0.9	-1.0	0.7
Hypertension (Self-reported)	0.6	1.6	3.1	-1.8	-0.4
Whole body fat-free mass	0.6	3.5	5.6	-1.2	2.4
Osteoarthritis (self-reported)	0.6	0.7	1.5	1.2	-0.0
Wears glasses or contact lenses	0.6	0.7	1.3	0.4	1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	-1.1	-0.5
Basal metabolic rate	0.6	3.4	5.3	-1.3	2.3
Diastolic blood pressure, automated reading	0.6	1.8	2.4	-1.0	-1.6
Commuting to job workplace: Cycle	0.6	0.8	0.8	-0.9	0.9
Supplements: Calcium	0.6	0.7	0.9	-0.7	1.0
Neuroticism (Nagel 2018)	0.5	1.1	1.7	1.3	0.7
Reaction Time	0.5	0.9	1.7	1.3	0.3
Height	0.5	9.7	17.1	-4.1	1.6
Waist Hip Ratio (WHR)	0.5	2.1	4.1	0.4	-2.0
Lung FEV1/FVC ratio	0.5	2.4	3.4	1.2	-1.8
Lung FVC	0.5	2.7	2.9	1.7	-1.6
Systolic blood pressure, automated reading	0.5	1.3	2.6	-1.6	-0.2
Angina	0.5	0.6	1.1	0.3	1.1
Serious illness, injury or assault to yourself	0.5	0.6	0.8	0.9	0.6
High blood pressure	0.5	1.3	2.6	-1.6	-0.2
Leg predicted mass (left)	0.5	2.8	5.3	-0.6	2.3
Trunk fat mass	0.5	2.1	2.3	-1.4	1.5
Mouth/teeth dental problems	0.5	0.7	1.0	-1.0	-0.7
Weight	0.5	2.4	3.1	-1.3	1.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.5	0.8	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	-0.0	-1.3
Comparative body size at age 10	0.5	1.4	1.8	-1.3	1.0
Number of children fathered	0.5	0.5	1.1	1.0	-0.1
Qualifications: College or University degree	0.5	1.6	3.0	-1.7	0.3
Arm predicted mass (right)	0.5	2.4	3.6	-1.1	1.9
Family relationship satisfaction	0.5	0.6	1.2	0.3	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.2	1.1	-0.4
Leg fat-free mass (right)	0.5	2.4	4.8	-0.3	2.2
Arm predicted mass (left)	0.5	2.4	2.9	-1.4	1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	-1.0	0.3
Irritable Bowel Disease (IBD)	0.4	1.0	1.7	1.3	-0.6
Ulcerative Colitis (UC)	0.4	0.7	1.2	1.1	-0.5
Prostate Cancer	0.4	0.5	0.9	0.4	-0.9
Mean Putamen Volume	0.4	0.5	0.8	0.3	-0.9
Lupus	0.4	0.7	0.9	-0.9	0.7
Rheumatoid Arthritis	0.4	0.6	0.8	-0.6	-0.9
Blood Eosinophil Count	0.4	3.5	6.6	-2.6	0.6
Hypothyroidism (self reported)	0.4	0.8	1.2	1.1	0.7
Neuroticism	0.4	1.0	1.1	1.1	0.9
Chronotype (morning person)	0.4	1.0	1.0	-1.0	1.0
Relative age of first facial hair	0.4	0.8	1.3	-1.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.8	-0.9	0.4
Loud music exposure frequency	0.4	0.5	0.9	0.9	0.3
Gout (self-reported)	0.4	0.6	0.7	0.8	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	-0.5	-0.8
Angina (self-reported)	0.4	0.5	1.0	0.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	1.0	0.2
Suffer from ‘nerves’	0.4	0.6	0.8	0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	-1.2	0.6
Leg predicted mass (right)	0.4	2.3	4.6	-0.3	2.1
Mother’s age at death	0.4	0.5	1.0	1.0	-0.1
Commuting to job workplace: Public transport	0.4	0.5	0.5	-0.7	0.7
Arm fat-free mass (left)	0.4	2.1	2.8	-1.2	1.7
Age started oral contraceptive pill	0.4	0.5	0.9	-1.0	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.4	1.6	-0.0
Alcohol drinker status: Previous	0.4	0.5	1.0	-0.0	1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	0.3	-1.2
Depression (Nagel 2018)	0.3	0.4	0.5	0.7	0.6
Schizophrenia (2018)	0.3	0.6	1.1	-0.1	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.1	0.9
Blood Red Count	0.3	2.8	3.8	1.3	-2.0
Cardiovascular Disease	0.3	1.1	1.9	-1.4	0.4
Trunk fat percentage	0.3	1.1	1.1	-1.0	1.0
Hand grip strength (right)	0.3	0.8	1.2	0.6	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-1.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.4	-0.7
Waist circumference	0.3	1.1	1.7	-0.6	1.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.7	-0.6
Forced vital capacity (FVC)	0.3	1.0	2.1	0.0	-1.4
Medication: Simvastatin	0.3	0.4	0.8	0.9	-0.2
Pulse rate	0.3	0.5	1.1	0.2	-1.0
Medication: Amlodipine	0.3	0.4	0.5	-0.6	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.9	-0.3
Birth weight	0.3	0.6	1.0	-0.4	-1.0
Number of full brothers	0.3	0.4	0.7	0.9	0.2
Shortness of breath walking on level ground	0.3	0.3	0.5	0.5	0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	-0.9	0.5
Migraine (self-reported)	0.3	0.4	0.5	0.7	0.5
Whole body fat mass	0.3	1.3	1.3	-1.2	1.1
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.8	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.5	0.3	-0.7
Mineral and other dietary supplements	0.3	0.4	0.6	0.5	0.8
Medication: Gliclazide	0.3	0.3	0.5	0.4	-0.7
Medication: Atorvastatin	0.3	0.4	0.4	0.7	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.8	-0.3
Unable to work because of sickness or disability	0.3	0.4	0.8	0.9	0.3
Myopia	0.3	0.5	1.0	-1.0	0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	0.0	-0.8
Bipolar Disorder (2018)	0.2	0.3	0.4	0.6	-0.6
Crohns Disease (2017)	0.2	0.4	0.4	0.7	-0.5
Ovarian Cancer	0.2	0.2	0.3	0.6	0.3
HDL Cholesterol	0.2	0.3	0.6	-0.8	0.1
Neuroticism (2016)	0.2	0.3	0.7	0.1	0.8
Schizophrenia (2014)	0.2	0.5	0.9	-0.3	-0.9
Blood White Count	0.2	1.5	3.0	0.2	1.7
Smoking Status	0.2	0.5	1.0	-0.3	1.0
Respiratory disease	0.2	0.4	0.6	-0.8	-0.3
Hair Pigment	0.2	5.0	8.0	2.8	-1.4
Vitamin and mineral supplements	0.2	0.3	0.5	-0.2	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.2	-0.8
Nervous feelings	0.2	0.4	0.6	-0.3	-0.8
Heart attack	0.2	0.3	0.5	0.1	-0.7
Allergy	0.2	0.5	1.0	1.0	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.4	0.5	0.6
Number of live births	0.2	0.3	0.3	-0.6	0.5
Happiness	0.2	0.2	0.4	-0.1	-0.6
Prospective memory result	0.2	0.2	0.4	0.3	-0.6
Illnesses of mother	0.2	0.3	0.5	0.0	0.7
Arm fat mass (right)	0.2	0.7	1.2	-0.5	1.1
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.6	0.4
Body fat percentage	0.2	0.6	0.8	-0.9	0.7
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.4	0.6
Mean time to correctly identify matches	0.2	0.4	0.6	0.4	0.8
Comparative height size at age 10	0.2	1.1	1.5	-1.2	0.9
Overall health rating	0.2	0.4	0.9	-0.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.0	-0.7
Smoking status: Previous	0.2	0.4	0.4	-0.6	0.6
Mood swings	0.2	0.4	0.5	0.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.5	0.7	-0.2
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.7	-0.3
Smoking status: Current	0.2	0.2	0.3	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	-0.2	-1.0
Arm fat mass (left)	0.2	0.8	1.4	-0.4	1.2
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.2	0.7
Medication: Blood pressure	0.2	0.4	0.8	-0.3	0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	0.7	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.2	0.7
Impedance of whole body	0.2	1.1	1.5	-1.2	-0.9
Worry (Nagel 2018)	0.1	0.3	0.5	0.2	-0.7
Tanning	0.1	0.8	1.6	0.1	-1.2
Pack years adult smoking proportion	0.1	0.1	0.1	0.2	-0.3
Current tobacco smoking	0.1	0.2	0.3	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.3	0.4
Supplements: Glucosamine	0.1	0.1	0.2	-0.4	0.3
Body mass index (BMI)	0.1	0.3	0.6	0.3	0.8
Had menopause	0.1	0.1	0.2	-0.3	0.4
Illnesses of siblings	0.1	0.2	0.2	0.5	-0.3
Impedance of arm (right)	0.1	0.3	0.5	-0.7	0.3
Arm fat percentage (right)	0.1	0.4	0.7	-0.3	0.9
Time employed in main current job	0.1	0.1	0.1	-0.3	-0.2
Medication: Cholesterol lowering	0.1	0.2	0.2	0.5	0.3
Depression (self-reported)	0.1	0.1	0.3	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.2	0.5	-0.5
Impedance of arm (left)	0.1	0.3	0.5	-0.7	0.2
Tense / ‘highly strung’	0.1	0.2	0.3	-0.6	-0.2
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	0.4	0.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.2	-0.4	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.3	-0.4
Medication: Blood pressure	0.1	0.1	0.3	-0.1	-0.5
Medication: Allopurinol	0.1	0.2	0.2	0.4	-0.4
Medication: Omeprazole	0.1	0.2	0.2	0.4	0.4
Leg fat mass (right)	0.1	0.5	0.6	-0.7	0.7
Pulse rate, automated reading	0.1	0.4	0.5	-0.6	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.2	0.3	0.4
Arm fat percentage (left)	0.1	0.5	1.0	0.0	1.0
Friendships satisfaction	0.1	0.1	0.1	-0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.1	-0.5
Medication for cholesterol	0.1	0.1	0.2	0.3	-0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.1	0.4
High cholesterol (Self-reported)	0.1	0.2	0.4	0.6	0.1
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.1	0.1	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.4	0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.6	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.1	0.6
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.5
Leg fat mass (left)	0.1	0.4	0.4	-0.6	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.3	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Medication for hormone replacement therapy	0.0	0.0	0.0	0.0	0.2
Maternal smoking around birth	0.0	0.0	0.0	-0.1	0.2
Fed-up feelings	0.0	0.0	0.0	0.2	-0.0
Qualifications: CSEs or equivalent	0.0	0.1	0.1	-0.2	-0.3
Worrier / anxious feelings	0.0	0.1	0.1	0.0	-0.3
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	-0.1
Birth weight of first child	0.0	0.0	0.0	0.0	0.2
High blood pressure (siblings)	0.0	0.0	0.0	-0.2	-0.1
Leg fat percentage (right)	0.0	0.1	0.2	-0.4	0.1
Average weekly red wine intake	0.0	0.0	0.0	-0.2	0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.0	0.1	0.2
Leg fat percentage (left)	0.0	0.0	0.1	-0.2	-0.2
Risk taking	0.0	0.0	0.1	-0.3	-0.0
Cholesterol lowering medication	0.0	0.0	0.1	-0.2	0.0
Pack years of smoking	0.0	0.1	0.1	0.2	-0.3

Hub : Genes

RNASEH2A

Models

Trait associations