TWAS hub - ACP5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0750	0.0320	8.4e-03	0.036	NA	0.013	NA	0.032	1.0e-03	NA	3.5e-02	NA	1.9e-03
2	GTEx	Esophagus Muscularis	0.1230	0.0440	1.2e-03	0.002	NA	0.022	NA	-0.001	2.4e-01	NA	1.6e-02	NA	3.6e-01
3	GTEx	Nerve Tibial	0.4162	0.1071	1.2e-03	0.044	NA	0.095	NA	0.034	4.4e-04	NA	3.0e-07	NA	1.8e-03
4	GTEx	Skin Sun Exposed Lower leg	0.1330	0.0410	3.4e-04	0.053	NA	0.081	NA	0.061	3.2e-05	NA	3.1e-07	NA	9.0e-06
5	GTEx	Testis	0.3250	0.0660	5.1e-07	0.182	NA	0.226	NA	0.206	1.7e-08	NA	2.3e-10	NA	1.6e-09
6	GTEx	Whole Blood	0.1530	0.0580	1.3e-03	0.024	NA	0.033	NA	0.038	2.6e-03	NA	5.0e-04	NA	1.9e-04
7	ROSMAP	Brain Pre-frontal Cortex	0.0469	0.0222	1.5e-02	0.044	0.02	0.007	0.023	0.026	2.2e-06	1.0e-03	3.6e-02	5.0e-04	2.3e-04
8	YFS	Blood	0.5488	0.0323	0.0e+00	0.333	0.47	0.514	0.509	0.509	2.8e-113	2.8e-176	9.6e-200	1.8e-197	1.9e-197

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8
Wears glasses or contact lenses	3.3	3.8	5.9	2.4	2.4	1.3	2.1	2.2	1.9	2.0
Falls in the last year	3.2	4.3	9.5	-1.5	-1.8	-1.3	-2.3	-3.1	-2.7	-2.3
Medication: Co-codamol	2.4	2.8	5.9	1.9	2.0	2.1	2.4	1.1	1.3	1.4
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	6.6	-2.0	-1.5	-2.6	-2.3	-0.3	-1.0	-1.5
Commuting to job workplace: Public transport	2.1	2.5	6.4	2.5	0.7	2.2	2.2	0.8	0.7	1.5
Severe depression (siblings)	2.0	2.2	10.1	0.1	-0.8	0.1	-1.4	-3.2	-1.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.7	9.4	-3.1	-2.6	-2.9	-2.2	-1.9	-2.1	-0.9
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	8.8	1.7	1.9	-0.0	2.6	1.7	3.0	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	8.0	-1.2	-1.3	-2.8	-1.6	0.6	0.5	2.0
Schizophrenia (2018)	1.8	3.7	8.0	-2.3	-1.2	-2.8	-2.3	-1.4	-2.0	-1.6
Father’s age at death	1.8	2.4	4.2	1.5	1.4	1.4	1.4	2.1	1.7	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	4.0	-2.0	-0.7	-1.9	-1.6	-1.8	-0.9	-1.3
Peak expiratory flow (PEF)	1.8	4.2	7.4	2.7	0.8	1.4	2.7	1.9	2.7	2.4
Medication: Omeprazole	1.8	2.2	7.2	-2.0	-1.6	-2.7	-1.7	0.1	-0.7	0.1
Number of full sisters	1.8	2.2	4.8	-1.2	-2.2	-1.0	-1.4	-1.7	-1.5	-1.9
Hand grip strength (left)	1.7	4.5	13.2	1.2	1.5	-0.1	2.2	2.6	2.7	3.6
Medication: Simvastatin	1.7	2.5	6.9	0.3	0.5	0.7	1.7	2.6	1.9	2.4
Eye problems/disorders: None of the above	1.7	1.9	6.2	-2.5	-0.8	-1.1	-2.1	-0.9	-1.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	6.4	-1.1	0.9	-1.9	-0.7	0.9	1.0	2.5
Alcohol drinker status: Never	1.7	2.0	5.7	-1.8	0.3	-1.7	-2.4	-0.8	-1.0	-1.7
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	6.4	2.5	1.1	1.4	1.9	1.0	1.2	0.9
Overall health rating	1.6	3.4	7.2	-2.7	-1.6	-2.5	-2.1	-1.4	-1.9	-0.9
Schizophrenia (2014)	1.5	3.3	7.8	-2.7	-1.2	-2.8	-2.4	-1.1	-1.5	-0.6
Medication: Cholesterol lowering	1.5	2.3	6.7	0.8	0.2	0.4	1.7	2.6	2.2	1.8
Birth weight	1.5	3.3	6.8	1.9	2.3	1.7	2.6	1.7	1.5	1.6
Age at last live birth	1.5	2.1	5.1	1.9	1.3	1.7	2.2	0.8	0.7	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	4.2	0.5	1.3	-0.3	1.8	1.5	2.0	1.4
Medication: Levothyroxine sodium	1.4	2.4	5.4	1.7	1.6	0.2	2.3	1.1	2.2	1.3
Leg pain on walking	1.4	1.8	3.7	1.5	1.3	0.8	1.9	1.2	1.6	1.4
Blood Platelet Count	1.3	15.1	29.2	-5.4	-3.7	-4.0	-4.9	-3.6	-4.0	-3.0
Hypothyroidism (self reported)	1.3	3.0	7.0	0.9	1.9	-0.9	1.9	1.9	2.6	2.1
Number of full brothers	1.3	1.7	4.8	-2.2	-0.6	-1.9	-2.1	-0.1	0.2	0.3
Number of children fathered	1.3	1.5	6.0	0.3	1.3	-0.8	0.6	1.2	1.4	2.5
Supplements: Vitamin C	1.3	1.5	3.2	1.5	1.2	1.8	1.1	1.5	1.3	0.2
Hand grip strength (right)	1.2	3.4	8.4	2.1	1.3	0.7	1.9	2.0	2.1	2.9
Fed-up feelings	1.2	2.2	4.4	-1.7	-1.2	-2.1	-1.4	-1.7	-1.9	0.6
Chronic bronchitis/emphysema (father)	1.2	1.4	4.4	0.1	1.6	-0.7	0.5	1.2	1.3	2.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.9	-1.5	-1.3	-1.1	-1.1	-2.2	-1.8	-1.2
Osteoporosis (self-reported)	1.2	1.5	4.6	-0.8	-0.5	0.9	-0.8	-1.2	-2.2	-1.9
Irritability	1.2	2.0	5.4	1.7	0.2	-0.7	1.7	1.4	1.4	2.3
Ever had prostate specific antigen (PSA) test	1.2	1.4	6.2	0.6	2.5	1.5	0.7	0.4	1.2	0.2
Alzheimer’s Disease (in father)	1.1	1.2	2.7	-0.9	-1.6	-1.5	-0.8	-0.4	-0.8	-1.6
Pack years adult smoking proportion	1.1	1.7	3.8	-0.9	-1.3	-0.9	-1.2	-2.0	-1.8	-1.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	3.3	-1.0	0.7	-0.6	-0.2	1.6	1.2	1.8
Impedance of arm (right)	1.1	5.2	17.9	-2.3	-0.5	0.6	-2.4	-2.1	-2.7	-4.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.1	-1.3	-1.0	-0.7	-1.3	-1.4	-1.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.2	1.3	0.7	0.7	1.4	1.5	1.4	1.3
Commuting to job workplace: Walk	1.1	1.2	2.6	0.3	-1.4	0.5	-1.1	-1.4	-1.6	-1.4
Myopia	1.1	1.6	5.5	-0.6	-0.2	0.2	-0.8	-1.5	-1.9	-2.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	4.8	-1.3	-1.4	-2.2	-1.4	0.4	-0.5	-0.1
Pack years of smoking	1.1	1.7	4.2	-0.8	-1.2	-0.7	-1.1	-2.0	-1.8	-1.4
Bipolar Disorder or Schizophrenia	1.0	2.5	5.0	-2.2	-0.3	-2.1	-2.2	-1.1	-1.8	-1.3
Smoking Status	1.0	2.5	6.7	0.6	0.9	-0.4	1.5	2.6	2.1	2.2
Medication for hormone replacement therapy	1.0	1.1	2.1	-1.3	-0.8	-1.4	-0.9	-1.1	-1.4	-0.6
Supplements: Zinc	1.0	1.1	3.0	0.9	-0.7	0.7	1.0	1.7	1.4	0.9
Impedance of arm (left)	1.0	4.6	17.3	-1.9	-0.3	0.8	-2.3	-2.0	-2.5	-4.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.9	-0.9	-0.3	0.5	-0.8	-1.3	-1.8	-2.0
Emphysema/chronic bronchitis	1.0	1.2	4.0	-0.4	0.5	-2.0	0.1	0.8	1.0	1.8
Had major operations	1.0	1.2	3.0	0.1	0.8	0.9	1.7	1.7	1.1	0.8
Cholesterol lowering medication	1.0	1.5	4.2	-2.1	-1.7	-1.1	-1.6	-0.2	-1.0	-0.5
Intelligence (Savage-Jansen 2018)	0.9	2.6	6.4	1.8	1.3	1.3	2.5	1.9	2.0	0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	2.8	-0.9	-1.7	-1.6	-1.5	0.0	-0.6	-0.8
Prostate Cancer	0.9	1.3	3.7	1.5	1.2	1.9	1.3	-0.8	-0.0	-0.3
Alcohol intake versus 10 years previously	0.9	1.4	4.0	-1.3	-1.9	-2.0	-0.8	-0.4	-0.1	0.9
Lung cancer (father)	0.9	1.1	3.0	-0.5	-1.4	0.1	-0.8	-1.7	-0.9	-1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	-1.5	-1.0	-1.4	-1.6	0.2	-0.2	1.1
Illnesses of siblings: Diabetes	0.9	1.1	1.9	1.4	1.2	1.4	1.0	0.8	0.5	1.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	5.7	0.3	0.3	-0.2	0.0	1.3	1.0	2.4
Miserableness	0.9	1.5	3.5	-1.4	-0.7	-1.2	-1.5	-1.9	-1.4	-0.2
Tinnitus: Yes, now most or all of the time	0.9	1.0	5.1	0.7	-0.5	2.3	1.3	-0.2	-0.7	-0.6
Alzheimer’s Disease (in mother)	0.8	0.9	2.6	-1.5	-0.4	-0.8	-1.6	0.0	-0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.8	-2.1	-1.3	-2.2	-1.2	-0.7	-0.9	0.3
Medication: Atenolol	0.8	1.0	2.3	1.2	1.4	1.5	1.3	-0.1	-0.1	0.5
Had menopause	0.8	1.0	3.3	-1.2	-0.0	0.1	-0.6	-1.4	-0.8	-1.8
Medication: Paracetamol	0.8	1.4	3.4	-1.4	-0.1	-0.5	-1.3	-1.8	-1.7	-1.0
Medication for cholesterol	0.8	1.2	2.2	1.5	1.2	1.2	1.5	0.8	1.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.4	-0.7	-1.4	-1.5	-1.5	-0.2	-0.4	0.6
Average weekly champagne plus white wine intake	0.8	1.1	3.3	-0.0	1.6	1.8	0.9	-0.3	-0.7	-1.3
Ever taken oral contraceptive pill	0.8	0.9	2.1	-0.4	-1.2	0.2	-0.5	-1.3	-1.2	-1.4
Medication: Blood pressure	0.8	1.5	3.6	-1.7	-1.5	-1.3	-1.9	-0.4	-1.0	0.4
Medication: Paracetamol	0.8	1.2	2.1	-1.2	-0.8	-0.8	-1.4	-1.4	-1.4	-0.9
Diastolic blood pressure, automated reading	0.8	2.6	7.5	-0.8	-1.1	0.0	-2.5	-2.0	-2.7	-1.0
Alcohol drinker status: Previous	0.8	0.9	2.0	0.9	1.2	1.2	1.4	1.0	0.2	0.4
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	-1.4	-0.9	-1.1	-1.7	0.2	-0.8	-0.8
Cardiovascular Disease	0.7	2.2	6.3	-1.8	-1.8	-1.1	-2.5	-0.8	-1.8	0.0
Respiratory disease	0.7	1.5	2.8	1.1	1.7	0.9	1.6	0.9	1.5	1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.3	1.8	1.3	1.7	0.7	1.1	0.9	0.8
Current tobacco smoking	0.7	1.1	2.8	0.4	0.1	-1.1	0.9	1.7	1.4	1.4
Stomach or abdominal pain in last month	0.7	0.9	2.2	-1.5	-0.4	-0.9	-0.8	-1.1	-1.1	-0.9
Heart attack	0.7	0.9	2.7	-0.7	-1.6	-1.2	-0.7	-1.2	-0.9	-0.6
Illnesses of siblings	0.7	1.0	2.6	-0.7	-1.6	-1.5	-0.9	-0.4	-0.8	-1.1
Time employed in main current job	0.7	0.8	2.1	-0.4	1.5	-0.9	0.1	0.9	1.2	1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.5	1.7	1.1	1.7	1.9	1.0	1.2	0.5
Mouth/teeth dental problems: Dentures	0.7	1.1	2.1	1.3	0.4	0.4	1.3	1.4	1.1	1.5
Breastfed as a baby	0.7	0.9	2.9	-0.5	-1.4	-1.0	-1.7	-0.4	-1.0	-0.3
Headache pain in last month	0.7	1.2	3.1	-0.3	-1.0	-1.8	-1.3	-1.4	-1.2	-0.3
Medication: Amlodipine	0.7	1.0	2.5	-1.5	-0.2	-0.9	-1.6	-0.7	-1.0	-0.7
Suffer from ‘nerves’	0.7	1.1	4.8	-0.4	-2.2	-0.8	-1.2	-0.5	-1.3	-0.1
Chest pain or discomfort	0.7	1.0	3.3	-0.5	-0.7	-1.5	-0.1	1.3	0.3	1.8
Smoking status: Current	0.7	1.1	2.5	0.1	-0.4	-1.6	0.8	1.6	1.2	1.4
Guilty feelings	0.7	1.0	3.5	1.8	-0.3	1.9	-0.2	-0.7	-1.0	0.2
Medication: Atorvastatin	0.7	0.9	2.7	-0.7	-1.6	-1.0	-1.5	0.0	-0.4	-0.5
Number of operations (self-reported)	0.7	1.0	2.2	0.5	0.1	-0.0	1.3	1.5	1.3	1.4
Risk taking	0.7	1.0	3.4	0.4	0.9	-0.5	0.9	1.8	1.4	0.9
Relative age of first facial hair	0.6	1.3	5.1	1.4	0.7	2.3	1.4	0.5	0.7	0.2
Medication: Metformin	0.6	0.9	1.6	1.0	1.2	1.3	1.0	1.2	0.9	0.5
Diabetes (mother)	0.6	0.7	1.3	-1.0	-1.0	-1.1	-0.8	-0.8	-0.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.3	-1.0	-0.4	-1.0	-1.1	-1.1	-1.1	-0.9
Taking other prescription medications	0.6	0.9	2.3	1.1	1.1	1.3	1.5	0.6	0.1	-0.3
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	0.9	-1.2	-0.4	0.9	0.4	1.1	1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	-0.2	-0.8	-0.8	-1.2	-0.7	-0.6	-1.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.7	0.6	1.6	0.7	0.5	0.8	1.2	0.1
Happiness	0.6	0.7	2.0	-0.3	-0.0	-0.3	-1.3	-1.3	-1.4	-0.3
Qualifications: College or University degree	0.6	1.9	6.6	1.5	1.0	2.6	2.0	0.3	0.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.8	-1.7	0.2	-1.7	-0.1	0.2	0.3	-0.1
Diabetes diagnosed by doctor	0.6	1.0	3.1	1.6	1.1	1.7	0.8	0.6	0.2	0.4
Qualifications: nursing, teaching	0.6	0.9	3.2	1.2	1.1	1.8	0.8	0.5	0.4	0.0
Number of self-reported non-cancer illnesses	0.6	1.1	2.6	1.2	1.3	-0.1	0.6	1.3	0.9	1.6
Eye problems/disorders: Glaucoma	0.6	0.7	2.7	1.6	0.1	0.4	1.2	0.4	0.9	0.9
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.7	-1.5	0.3	-1.6	-0.3	-0.5	-0.5	-0.5
Illnesses of father: High blood pressure	0.6	0.7	3.0	1.7	-0.3	-0.3	0.2	1.2	0.8	0.7
Impedance of whole body	0.6	3.2	13.4	-1.6	-0.7	0.8	-1.8	-1.2	-1.9	-3.7
Depressed Affect (Nagel 2018)	0.5	1.1	2.9	-0.7	-0.6	-0.7	-1.3	-1.7	-1.7	-0.4
Fasting Glucose	0.5	0.5	1.7	-0.8	-0.4	-0.8	-1.3	-0.8	-0.6	-0.5
Heel T-Score	0.5	4.2	16.2	-4.0	-1.4	-3.1	-0.9	-1.7	-1.5	0.1
Systolic Blood Pressure	0.5	2.5	9.1	-0.6	-2.2	-0.5	-3.0	-1.0	-1.8	1.0
Lung FEV1/FVC ratio	0.5	2.7	6.7	-1.1	-2.6	-1.0	-2.0	-1.9	-1.9	-1.3
Chronotype (morning person)	0.5	1.0	2.7	0.3	0.7	-0.5	0.3	1.6	1.6	1.5
Supplements: Glucosamine	0.5	0.6	2.4	0.5	0.5	1.1	1.5	0.5	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	0.8	-0.3	0.6	-0.7	-1.2	-1.3	-0.5
Sitting height	0.5	3.9	8.3	2.9	0.7	1.2	2.5	2.6	2.1	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.4	-0.5	-1.3	-1.5	-0.6	0.5	-0.1	0.9
Blood clot in the leg (DVT)	0.5	0.7	2.2	1.5	0.3	0.8	0.1	0.9	0.9	0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-0.9	0.8	0.1	-1.1	-0.8	-1.2	-0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	0.6	1.2	1.3	0.6	0.6	0.1	0.7
Illnesses of father: Heart disease	0.5	0.7	2.6	0.3	-0.0	-1.1	0.5	0.7	1.1	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.8	-1.6	-0.4	-1.7	-1.1	-0.7	-0.8	-0.3
Loneliness, isolation	0.5	0.7	2.8	-0.1	-0.7	0.3	-0.9	-1.2	-1.7	-0.3
Osteoarthritis (self-reported)	0.5	0.6	1.7	1.3	1.1	0.7	0.8	0.6	0.7	0.2
High cholesterol (Self-reported)	0.5	0.8	2.1	-1.5	-0.8	-0.8	-1.1	0.9	0.4	1.0
Commuting to job workplace: Cycle	0.5	0.6	1.9	0.8	1.4	1.0	0.7	-0.4	0.2	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	2.6	1.1	-1.6	0.7	0.0	0.4	-0.2	-0.4
Irritable Bowel Disease (IBD)	0.4	0.9	2.4	1.5	0.5	-0.0	1.1	1.3	1.0	0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.2	0.5	0.9	1.4	1.8	0.4	1.0	-0.5
Coronary Artery Disease (CAD)	0.4	0.5	2.2	-0.3	-0.7	-0.8	-1.5	0.0	-0.4	-0.7
Mean Putamen Volume	0.4	0.5	1.5	0.7	1.1	1.2	0.6	-0.4	0.4	0.5
Neuroticism (2016)	0.4	0.6	3.0	-0.2	-0.4	0.6	0.4	-0.6	-0.8	1.7
Rheumatoid Arthritis	0.4	0.6	2.0	0.4	1.1	-0.6	1.4	0.3	0.9	0.6
Waist Hip Ratio (WHR)	0.4	1.9	4.1	-2.0	-0.7	-1.9	-1.4	-1.6	-1.4	-0.6
Allergy or Eczema	0.4	1.1	3.2	0.7	1.8	1.3	1.0	0.6	1.1	0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-0.1	-0.8	-0.9	-0.7	-0.8	-1.0	-0.5
Age when periods started (menarche)	0.4	1.0	3.0	1.0	0.6	0.7	0.5	1.7	1.1	1.3
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-1.2	-0.5	-0.8	-0.6	-1.2	-1.1	-0.4
Diabetes (self-reported)	0.4	0.7	1.8	1.4	1.1	1.3	0.1	0.6	0.3	0.4
Medication: Ramipril	0.4	0.5	1.2	-1.1	0.3	-0.8	-0.1	1.0	0.3	1.1
Fluid intelligence score	0.4	0.9	3.3	0.6	0.6	1.6	1.8	0.2	0.5	-0.3
Trunk fat-free mass	0.4	2.4	7.4	2.1	0.9	-0.3	1.2	1.5	1.7	2.7
Trunk predicted mass	0.4	2.5	7.6	2.1	0.9	-0.2	1.3	1.5	1.8	2.8
Length of working week for main job	0.4	0.4	1.2	0.0	1.1	-0.9	0.1	0.1	0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.5	0.5	1.6	1.0	1.0	0.5	0.4	0.1
Gout (self-reported)	0.4	0.6	3.9	0.8	0.3	2.0	-0.0	0.3	-0.2	-0.2
Mean time to correctly identify matches	0.4	0.7	2.6	1.0	1.6	1.2	0.6	0.4	0.5	-0.3
Smoking status: Previous	0.4	0.6	2.9	-0.0	1.7	0.8	-0.2	0.4	0.6	0.8
Ever had bowel cancer screening	0.4	0.4	1.9	0.2	0.7	0.9	1.4	0.4	0.3	0.0
Friendships satisfaction	0.4	0.5	1.4	0.6	0.7	0.9	0.7	-0.7	-0.5	-1.2
Eye problems/disorders: Cataract	0.4	0.5	2.6	1.6	-0.0	0.2	0.5	0.3	0.3	0.8
Back pain experienced in last month	0.4	0.5	1.3	0.4	0.1	1.2	1.1	1.1	0.1	-0.2
Medication: Gliclazide	0.4	0.4	2.0	1.4	0.2	0.9	0.5	0.5	-0.1	0.2
Mother’s age at death	0.4	0.5	1.5	0.6	1.2	0.8	0.9	0.4	0.3	-0.1
Financial situation satisfaction	0.4	0.5	1.6	1.2	0.5	1.3	0.6	0.5	0.0	0.1
Medication: Lisinopril	0.4	0.5	1.7	0.9	-0.2	0.8	-0.7	0.7	-0.0	1.3
Arm fat-free mass (left)	0.4	2.0	7.2	1.6	0.7	-0.3	1.0	1.3	1.6	2.7
Ever depressed for a whole week	0.4	0.5	2.0	-0.0	-0.2	0.5	-0.7	-0.4	-1.0	-1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.9	-0.5	-1.4	-0.8	-0.5	-0.8	-0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	1.1	0.0	0.4	-0.0	0.9	0.9	0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.9	0.2	-0.9	-0.3	-1.1	-1.2	-1.4	-0.5
Worry (Nagel 2018)	0.3	0.7	2.2	-0.5	-0.9	-1.0	-1.5	-0.7	-0.9	-0.5
Ulcerative Colitis (UC)	0.3	0.5	1.6	1.1	0.1	-0.1	0.3	0.9	0.6	1.3
Crohns Disease (2012)	0.3	0.4	1.3	0.5	0.1	1.1	-0.4	0.0	-0.6	-1.1
HDL Cholesterol	0.3	0.5	1.3	-1.0	0.8	-0.8	-0.4	0.0	-0.7	-1.1
Triglycerides	0.3	0.4	1.2	0.7	0.6	0.5	0.3	0.0	1.1	1.1
Ulcerative Colitis	0.3	0.5	1.4	1.2	0.8	0.8	0.8	0.4	0.4	0.3
Lung FVC	0.3	1.5	3.4	-0.7	-1.8	-0.5	-0.3	-1.4	-1.7	-1.8
Number of treatments/medications taken	0.3	0.5	1.4	-0.4	-1.2	-1.0	-0.7	0.3	-0.7	-0.2
Average weekly spirits intake	0.3	0.4	1.5	0.1	-0.4	-0.7	-0.7	-0.2	-0.7	1.2
Hearing difficulty/problems: Yes	0.3	0.4	2.1	0.7	0.5	0.4	1.4	-0.3	0.0	0.6
Vitamin and mineral supplements	0.3	0.4	0.9	-0.9	0.6	-0.7	-0.8	-0.8	-0.7	0.0
Townsend deprivation index at recruitment	0.3	0.4	1.4	0.6	-1.2	-0.8	-0.6	0.7	-0.1	0.2
Average weekly fortified wine intake	0.3	0.3	1.3	1.2	-0.1	-0.2	-0.1	-0.1	0.0	1.0
Qualifications: CSEs or equivalent	0.3	0.3	1.0	0.7	0.3	0.9	0.0	-0.6	-1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.8	0.6	1.2	0.6	0.6	0.9	1.4	0.6
Past tobacco smoking	0.3	0.5	1.8	0.2	-1.3	-0.4	0.4	-0.8	-0.5	-0.9
Had other major operations	0.3	0.4	0.8	0.9	-0.8	0.5	0.1	0.7	0.4	0.8
Financial difficulties in last 2 years	0.3	0.4	2.0	-0.1	-0.3	-0.2	-0.8	-0.3	-0.7	1.4
Mouth/teeth dental problems	0.3	0.5	1.7	-0.7	-0.9	-1.3	-0.8	-0.4	-0.1	0.0
Arm fat percentage (right)	0.3	1.0	2.0	-1.4	0.4	-0.8	-1.4	-1.3	-1.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.9	-0.6	-0.2	-0.9	-0.6	-1.4	-1.0	-0.4
Number of live births	0.3	0.4	1.5	-0.8	-0.3	-0.7	-0.4	1.2	0.4	0.6
Asthma	0.3	0.6	2.0	0.6	1.1	1.1	1.4	0.2	0.3	0.3
Medication: Lansoprazole	0.3	0.4	0.9	0.8	0.1	0.5	0.8	0.5	0.9	0.3
Loud music exposure frequency	0.3	0.4	1.4	0.6	-0.7	0.4	-1.2	-0.2	-0.4	0.3
Arm fat-free mass (right)	0.3	1.8	6.6	1.3	0.3	-1.1	0.7	1.4	1.6	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	0.7	0.3	-0.2	-0.5	0.8	0.4	1.0
Wheeze or whistling in the chest in last year	0.3	0.6	2.9	-0.8	-0.8	-1.7	-0.1	-0.4	-0.4	-0.1
Age at first live birth	0.3	0.5	1.6	0.5	0.7	0.7	1.3	-0.4	-0.5	-0.5
Health satisfaction	0.3	0.4	1.7	-0.3	0.3	-0.7	-0.1	0.7	0.5	1.3
Shortness of breath walking on level ground	0.3	0.4	1.3	-0.1	0.2	-0.2	0.1	1.1	0.8	1.2
Migraine (self-reported)	0.3	0.4	1.4	0.0	-1.2	-0.6	-1.2	-0.4	-0.2	-0.2
Heart disease (mother)	0.3	0.3	0.8	0.6	0.2	0.5	0.8	0.5	0.9	-0.5
Arm predicted mass (right)	0.3	1.7	6.1	1.6	0.5	-0.6	0.9	1.1	1.5	2.5
Pulse rate, automated reading	0.3	0.8	2.1	0.0	-0.6	-0.3	-1.1	-1.5	-1.2	-1.2
Alcohol intake frequency.	0.3	0.7	3.6	-0.7	-0.5	-1.9	-1.2	-0.4	-0.3	0.0
Whole body fat-free mass	0.3	1.5	5.9	1.5	0.8	-0.6	0.7	1.0	1.3	2.4
Arm fat percentage (left)	0.3	1.3	2.7	-1.6	0.4	-1.1	-1.6	-1.4	-1.1	-0.8
Average weekly red wine intake	0.3	0.4	2.2	0.3	1.5	0.7	0.7	0.3	0.3	-0.0
Mood swings	0.3	0.6	3.4	0.2	0.1	-1.1	0.0	-0.2	-0.4	1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.5	-0.3	0.9	-0.1	-0.8	-1.2	-0.4	-0.5
Mineral and other dietary supplements	0.3	0.5	1.4	-1.2	0.1	-0.6	-0.9	-0.7	-0.7	0.1
Breast cancer (self-reported)	0.3	0.4	1.3	0.1	-0.3	-1.0	0.4	0.4	1.1	0.4
Asthma (self-reported)	0.3	0.6	1.9	0.6	1.0	1.1	1.4	0.3	0.5	0.4
Whole body water mass	0.3	1.5	5.7	1.5	0.9	-0.6	0.7	1.0	1.3	2.4
Ever smoked	0.3	0.5	2.4	-0.4	1.5	0.1	-0.3	0.8	0.5	0.8
Fractured/broken bones in last 5 years	0.3	0.4	1.1	1.0	-0.7	1.0	-0.2	0.3	-0.5	0.2
Arm predicted mass (left)	0.3	1.7	6.7	1.4	0.6	-0.7	0.9	1.1	1.5	2.6
Bipolar Disorder (2018)	0.2	0.3	1.5	-0.7	1.2	0.1	-0.3	0.0	-0.4	-0.1
Depression (Nagel 2018)	0.2	0.4	1.2	-0.3	0.0	-0.6	-0.6	-1.1	-0.8	-0.4
Crohns Disease (2017)	0.2	0.3	1.3	0.8	0.3	0.2	1.2	0.4	0.5	-0.3
Breast Cancer	0.2	0.4	1.7	1.0	-0.2	0.6	1.3	0.3	0.7	0.1
Ovarian Cancer	0.2	0.3	1.0	-0.6	0.3	-0.7	-0.1	1.0	0.6	0.4
Age at First Birth	0.2	0.3	1.9	0.2	0.0	0.4	0.3	0.0	0.7	1.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.4	0.8	0.4	-0.9	0.0	-0.4	-0.7
LDL Cholesterol	0.2	0.4	1.2	-1.1	0.6	1.0	-0.8	0.0	0.0	0.2
Lupus	0.2	0.2	0.7	0.8	-0.3	0.4	0.1	-0.6	-0.8	0.2
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.7	0.3	-0.3	0.2	0.8	0.9	0.8
Blood Red Count	0.2	1.5	5.0	2.2	0.1	1.3	2.1	0.5	0.5	-0.6
Blood White Count	0.2	1.4	8.5	0.8	-2.9	-0.8	1.1	0.1	-0.2	0.3
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.9	0.6	0.4	-0.5	-0.4	-0.4	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.5	-0.4	-0.8	-0.5	-0.5	-0.6	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	-0.7	0.5	-0.1	-0.9	0.1	-0.0	-0.5
Systolic blood pressure, automated reading	0.2	0.7	3.0	0.6	-1.7	0.7	-0.5	-0.1	-0.6	1.0
Angina	0.2	0.3	0.8	-0.9	-0.7	-0.5	-0.0	0.3	-0.3	-0.7
Diabetes (father)	0.2	0.3	1.5	0.6	0.3	-0.2	0.1	0.2	0.3	1.2
Impedance of leg (right)	0.2	0.9	4.4	-0.8	-0.6	0.6	-0.8	-0.4	-0.9	-2.1
Trunk fat percentage	0.2	0.9	2.0	-1.3	-0.0	-0.5	-1.4	-1.0	-1.0	-0.9
Maternal smoking around birth	0.2	0.3	0.7	-0.6	-0.8	-0.8	-0.5	-0.3	-0.6	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.6	0.8	-0.0	0.3	-0.8	-0.3	-0.4	-0.8
High blood pressure (mother)	0.2	0.3	0.7	0.1	0.5	-0.7	-0.9	0.2	0.5	0.7
Impedance of leg (left)	0.2	1.1	4.7	-1.2	-0.7	0.4	-1.0	0.0	-0.9	-2.2
Waist circumference	0.2	0.6	1.6	-0.6	-0.2	-0.9	-1.3	-1.1	-0.9	0.1
Alcohol usually taken with meals	0.2	0.4	1.3	-0.5	1.1	1.0	0.0	0.6	0.4	0.2
Nervous feelings	0.2	0.4	1.2	-0.2	-0.9	-0.5	-1.1	-0.1	-0.6	-0.5
Allergy	0.2	0.4	1.0	-0.1	-0.9	-0.3	-0.4	-0.8	-1.0	-0.7
Neuroticism score	0.2	0.4	0.9	-0.1	-0.0	-0.7	-0.8	-0.7	-0.7	0.9
Worrier / anxious feelings	0.2	0.3	1.7	0.4	0.5	-0.2	0.0	0.5	0.6	1.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.2	-0.5	0.9	0.1	0.3	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	0.5	1.0	0.3	-0.3	0.3	0.0	1.0
Depression (self-reported)	0.2	0.2	0.7	0.4	-0.0	-0.0	0.8	-0.3	-0.3	0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	-0.0	0.3	-0.9	-0.4	0.5	0.3	0.8
Standing height	0.2	1.6	4.9	2.2	1.2	1.4	0.9	1.4	1.3	0.7
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.3	-0.8	-0.0	0.1	0.7	0.1	-0.1
Hair/balding pattern: Pattern 4	0.2	0.4	1.8	-0.7	-1.4	-0.8	-0.2	-0.4	-0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.0	-0.9	0.7	-1.0	-0.1	-0.3	-0.0	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.8	-0.3	0.1	0.3	0.4	0.6	0.6
High blood pressure (siblings)	0.2	0.3	0.7	-0.5	0.9	0.6	-0.8	-0.2	-0.2	0.4
Comparative body size at age 10	0.2	0.7	1.9	-1.4	0.9	-0.9	-0.3	-1.0	-0.8	0.5
Pulse wave peak to peak time	0.2	0.2	0.9	0.3	-0.2	1.0	0.5	-0.3	-0.1	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.9	0.1	0.7	0.5	0.5	-0.3	-0.8	-1.0
Medication: Blood pressure	0.2	0.3	1.0	1.0	0.8	0.6	-0.1	0.5	-0.1	0.3
Angina (self-reported)	0.2	0.3	0.8	-0.9	-0.6	-0.7	0.1	0.4	0.0	-0.4
Medication: Ibuprofen	0.2	0.2	0.5	0.6	-0.2	-0.3	-0.7	-0.0	-0.4	0.6
Medication: Allopurinol	0.2	0.3	1.2	0.8	0.1	1.1	0.1	0.3	-0.2	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.6	-0.2	-0.8	-0.5	0.1	-0.4	0.3
Knee pain experienced in last month	0.2	0.3	1.2	0.1	-1.1	-0.5	0.3	-0.7	-0.5	-0.3
Hypertension (Self-reported)	0.2	0.7	1.5	-1.1	-0.3	-1.2	-1.2	0.0	-0.8	0.7
Long-standing illness, disability or infirmity	0.2	0.3	1.5	1.2	-0.7	0.1	0.1	-0.4	-0.5	-0.0
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.6	0.4	0.8	0.1	-0.7	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	0.5	-0.8	0.7	1.2	-0.1	-0.2	-0.5
Hearing aid user	0.2	0.2	1.0	0.2	-1.0	-0.5	-0.4	0.2	-0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.2	1.1	0.1	-0.2	0.5	0.5	0.8	-0.2
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.4	0.6	0.7	0.0	0.6	0.4	0.9
Basal metabolic rate	0.2	1.1	4.4	1.2	0.8	-0.6	0.4	0.7	1.0	2.1
Age started oral contraceptive pill	0.2	0.2	0.7	-0.3	-0.8	-0.1	0.5	-0.2	-0.5	-0.7
Unable to work because of sickness or disability	0.2	0.3	1.4	0.1	-0.6	-0.3	-0.4	-1.2	-0.6	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.0	0.8	0.6	0.9	0.6	-0.6	0.2	-1.4
Supplements: Calcium	0.2	0.3	1.1	-0.3	-0.6	0.3	-0.6	0.2	-0.2	-1.1
Heart disease (siblings)	0.2	0.2	0.8	-0.3	0.9	0.4	0.2	0.3	0.6	0.1
Major Depression (MDD)	0.1	0.1	0.6	-0.1	-0.4	0.0	-0.3	0.0	-0.8	0.2
Reaction Time	0.1	0.2	0.9	-0.0	0.5	-0.1	-0.9	-0.3	-0.3	-0.5
HbA1C	0.1	0.1	0.6	0.8	0.3	0.2	0.0	-0.4	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.6	-0.0	-0.2	-0.1	0.0	-0.4	-0.3
Blood Eosinophil Count	0.1	0.6	2.2	-0.7	-0.8	-1.5	-0.7	0.5	0.6	0.6
Neuroticism	0.1	0.3	0.8	0.9	0.8	0.7	0.1	0.1	0.0	0.8
Leg fat-free mass (left)	0.1	0.6	2.9	0.7	0.8	-0.9	-0.2	0.1	0.5	1.7
Relative age voice broke	0.1	0.2	0.6	-0.0	0.7	0.6	0.8	-0.3	0.4	-0.1
High blood pressure	0.1	0.4	0.9	-0.8	-0.1	-0.7	-0.9	0.5	-0.4	1.0
Multivitamins +/- minerals	0.1	0.1	0.3	0.3	-0.2	-0.2	0.1	0.5	0.5	0.2
Body mass index (BMI)	0.1	0.3	1.3	-0.3	0.1	-1.1	-0.5	-0.3	0.0	1.1
Leg predicted mass (left)	0.1	0.6	2.9	0.7	0.7	-0.9	-0.2	0.0	0.4	1.7
Trunk fat mass	0.1	0.3	0.9	-0.6	0.3	-0.5	-0.9	-0.5	-0.5	-0.2
Number of incorrect matches in round	0.1	0.2	1.0	0.2	-0.2	-1.0	-0.5	-0.5	0.1	0.1
Pain all over the body in last month	0.1	0.1	0.4	0.1	-0.3	-0.6	-0.2	-0.3	0.5	0.6
Weight	0.1	0.3	1.2	0.7	0.5	-0.3	-0.1	0.1	0.3	1.1
Pulse rate	0.1	0.2	0.5	-0.7	-0.5	-0.0	-0.6	-0.4	-0.6	0.4
Noisy workplace	0.1	0.2	0.4	0.3	0.4	0.6	-0.1	0.5	0.4	0.4
Prospective memory result	0.1	0.2	0.9	0.9	0.3	0.3	-0.3	0.4	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.4	-0.5	0.6	-0.1	-0.7	-0.7	-1.0
Arm fat mass (right)	0.1	0.5	1.2	-0.8	0.4	-0.8	-1.1	-1.0	-0.6	0.1
Tense / ‘highly strung’	0.1	0.1	0.3	-0.3	0.2	-0.5	0.0	0.4	0.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.6	0.4	0.1	-0.1	-0.8	-0.1	-0.5	0.0
Birth weight of first child	0.1	0.1	0.5	-0.3	0.4	-0.0	0.7	0.3	-0.0	-0.2
Pulse wave reflection index	0.1	0.2	0.5	-0.2	0.7	-0.2	-0.5	0.7	0.0	-0.2
Glaucoma (self-reported)	0.1	0.1	0.5	-0.3	0.2	-0.7	0.2	-0.3	0.1	0.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.7	0.7	-0.2	0.6	0.2	-0.2	-0.4	-0.8
Body fat percentage	0.1	0.5	1.3	-1.1	0.3	-0.7	-1.1	-0.7	-0.6	-0.3
Worry too long after embarrassment	0.1	0.2	1.1	-0.1	-1.0	0.4	-0.1	-0.5	-0.6	-0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	-0.3	-0.4	0.0	-0.7	-0.3	-0.3	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.1	0.2	0.3	0.6	-0.1	0.6	-0.1
Whole body fat mass	0.1	0.4	1.0	-0.6	0.5	-0.7	-1.0	-0.7	-0.4	0.2
Leg fat mass (right)	0.1	0.4	1.7	0.1	0.7	-0.7	-0.2	0.2	0.4	1.3
Family relationship satisfaction	0.1	0.1	0.4	0.1	-0.3	-0.1	-0.0	-0.6	-0.5	-0.1
Medication: Aspirin	0.1	0.1	0.5	0.2	0.2	0.5	0.4	0.7	-0.0	0.2
Leg fat-free mass (right)	0.1	0.6	2.9	0.5	0.7	-1.0	-0.2	0.2	0.5	1.7
Medication: Aspirin	0.1	0.1	0.3	0.2	-0.2	-0.0	0.3	0.6	0.0	0.5
Leg predicted mass (right)	0.1	0.6	2.7	0.4	0.6	-1.1	-0.3	0.1	0.4	1.7
Arm fat mass (left)	0.1	0.6	1.5	-0.7	0.3	-0.8	-1.2	-1.1	-0.7	0.0
Leg fat percentage (left)	0.1	0.3	0.8	-0.5	0.5	-0.7	-0.4	0.4	0.3	0.9
Average weekly beer plus cider intake	0.1	0.2	0.8	-0.1	0.2	0.1	-0.7	0.0	0.1	0.9
Pain experienced in last month	0.1	0.2	0.9	0.4	0.2	0.9	0.3	0.4	0.1	-0.1
Leg fat mass (left)	0.1	0.4	1.3	-0.2	0.6	-0.9	-0.5	0.3	0.3	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.2	0.4	0.6	0.3	-0.4	-0.6	-0.1	0.5	0.6
Height	0.0	0.4	2.1	1.4	-0.4	0.6	-0.6	0.4	0.5	-0.2
Hair Pigment	0.0	0.3	0.7	-0.8	-0.0	-0.1	0.5	0.8	0.3	0.6
Tanning	0.0	0.3	0.7	-0.1	-0.8	-0.5	-0.4	-0.7	-0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.2	-0.4	-0.1	-0.3	-0.1	-0.2	-0.1	0.1
Forced vital capacity (FVC)	0.0	0.1	0.3	0.5	-0.4	0.3	0.4	0.6	0.2	0.1
Qualifications: None of the above	0.0	0.1	0.4	-0.3	0.2	-0.6	0.2	-0.2	0.4	0.3
Hip circumference	0.0	0.2	1.0	0.4	-0.1	-0.2	-0.5	0.1	0.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.5	0.7	-0.3	0.3	0.5	0.3	0.3	0.2
Illnesses of mother	0.0	0.0	0.1	-0.1	0.2	-0.3	0.1	-0.2	-0.1	-0.0
Leg fat percentage (right)	0.0	0.2	0.7	-0.2	0.5	-0.5	-0.2	0.2	0.2	0.9
Comparative height size at age 10	0.0	0.2	0.5	0.7	-0.5	0.1	-0.6	-0.3	-0.6	-0.6

Hub : Genes

ACP5

Models

Trait associations