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chr2:66,927,859-71,471,456

Best TWAS P=1.58e-46 · Best GWAS P=3.87e-47 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ARHGAP25	0.27	0.27	bslmm	586	0.33	5.5e-41	7.8	-8.8	1.9e-18	0.03	0.00	1.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ASPRV1	0.05	0.03	bslmm	344	0.03	1.0e-04	1.8	-8.2	3.0e-16	0.39	0.74	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ETAA1	0.15	0.13	enet	34	0.16	6.2e-19	4.3	5.1	2.9e-07	0.01	0.22	0.73	TRUE
4	CommonMind	Brain Pre-frontal Cortex	GMCL1	0.06	0.09	lasso	2	0.09	1.5e-10	-8.5	8.5	1.4e-17	-0.46	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	SNRNP27	0.04	0.03	lasso	3	0.03	2.1e-04	-8.6	5.2	1.8e-07	-0.23	0.85	0.00	FALSE
6	GTEx	Adipose Subcutaneous	GMCL1	0.03	0.04	enet	5	0.02	1.0e-02	-9.2	-9.7	3.2e-22	0.52	0.49	0.18	TRUE
7	GTEx	Adipose Subcutaneous	GFPT1	0.07	0.04	enet	11	0.01	6.9e-02	-4.1	5.8	8.5e-09	-0.32	0.62	0.05	FALSE
8	GTEx	Adipose Visceral Omentum	GMCL1	0.07	0.04	lasso	4	0.01	7.4e-02	-7.2	-8.7	4.2e-18	0.43	0.17	0.13	FALSE
9	GTEx	Adrenal Gland	SNRNP27	0.13	0.04	lasso	5	0.11	1.3e-04	-13.2	10.3	1.1e-24	-0.65	0.06	0.57	TRUE
10	GTEx	Artery Aorta	PCYOX1	0.12	0.04	lasso	3	0.02	1.6e-02	-7.0	-7.0	1.9e-12	0.34	0.35	0.04	FALSE
11	GTEx	Artery Aorta	GFPT1	0.24	0.10	lasso	8	0.19	1.0e-10	-3.1	5.9	4.6e-09	-0.31	1.00	0.00	FALSE
12	GTEx	Artery Tibial	FAM136A	0.11	0.02	enet	13	0.05	8.2e-05	1.8	6.0	2.6e-09	-0.28	0.52	0.18	TRUE
13	GTEx	Artery Tibial	PCYOX1	0.22	0.18	lasso	4	0.17	1.3e-13	-6.9	-6.9	5.5e-12	0.34	1.00	0.00	FALSE
14	GTEx	Brain Cerebellum	GMCL1	0.13	0.11	lasso	3	0.10	5.1e-04	-8.6	8.3	9.8e-17	-0.43	0.12	0.40	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	FAM136A	0.31	0.12	lasso	7	0.16	5.6e-06	4.7	6.7	2.4e-11	-0.13	0.74	0.08	TRUE
16	GTEx	Colon Sigmoid	PCYOX1	0.19	0.00	enet	27	0.00	3.0e-01	2.4	-5.2	2.2e-07	0.29	0.09	0.05	FALSE
17	GTEx	Colon Transverse	PCYOX1	0.13	0.01	lasso	3	0.00	2.7e-01	-4.8	-6.1	8.2e-10	0.36	0.22	0.04	TRUE
18	GTEx	Colon Transverse	GFPT1	0.20	0.23	lasso	4	0.22	4.9e-11	-3.0	5.8	5.2e-09	-0.30	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	PCYOX1	0.18	0.16	enet	14	0.15	1.9e-09	-7.0	-7.9	2.1e-15	0.41	1.00	0.00	FALSE
20	GTEx	Esophagus Muscularis	AC022201.5	0.14	0.04	enet	22	0.06	8.7e-05	3.1	5.3	1.1e-07	-0.23	0.81	0.01	FALSE
21	GTEx	Lung	FAM136A	0.10	0.00	lasso	3	0.00	4.3e-01	-6.8	7.2	5.2e-13	-0.39	0.06	0.09	FALSE
22	GTEx	Lung	AAK1	0.05	0.00	lasso	5	0.01	2.7e-02	-4.0	-5.9	3.8e-09	0.28	0.14	0.14	FALSE
23	GTEx	Lung	ANXA4	0.22	0.03	enet	16	0.05	1.6e-04	-6.4	5.8	5.6e-09	-0.24	0.90	0.00	FALSE
24	GTEx	Muscle Skeletal	GMCL1	0.13	0.07	lasso	6	0.11	4.5e-11	-8.6	13.2	9.4e-40	-0.80	0.04	0.96	FALSE
25	GTEx	Pancreas	AC022201.5	0.14	-0.01	lasso	8	-0.01	6.7e-01	-7.0	7.0	2.8e-12	-0.31	0.07	0.09	FALSE
26	GTEx	Pancreas	ASPRV1	0.21	0.02	enet	17	0.04	5.8e-03	2.3	-6.2	5.7e-10	0.19	0.07	0.13	TRUE
27	GTEx	Skin Not Sun Exposed Suprapubic	PCYOX1	0.14	0.03	lasso	6	0.02	2.2e-02	-5.5	-6.0	1.7e-09	0.32	0.14	0.19	FALSE
28	GTEx	Skin Sun Exposed Lower leg	FAM136A	0.11	0.05	enet	42	0.06	5.1e-06	-6.8	5.4	8.4e-08	-0.28	0.78	0.02	TRUE
29	GTEx	Small Intestine Terminal Ileum	GFPT1	0.24	0.01	enet	19	0.03	8.5e-02	-2.9	6.4	1.6e-10	-0.30	0.07	0.15	TRUE
30	GTEx	Thyroid	SNRNP27	0.12	0.05	enet	11	0.06	1.6e-05	2.7	5.5	3.4e-08	-0.39	0.70	0.14	FALSE
31	METSIM	Adipose	GFPT1	0.07	0.06	blup	460	0.08	1.0e-11	-3.1	6.7	1.9e-11	-0.36	1.00	0.00	FALSE
32	NTR	Blood	GMCL1	0.06	0.05	lasso	7	0.05	4.4e-15	-13.9	-14.3	1.6e-46	0.86	0.05	0.95	TRUE
33	ROSMAP	Brain Pre-frontal Cortex	FAM136A	0.09	0.08	lasso	3	0.06	9.9e-09	-6.1	5.6	1.7e-08	-0.34	1.00	0.00	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	GMCL1	0.16	0.17	lasso	9	0.18	1.5e-22	-8.6	11.3	2.0e-29	-0.62	1.00	0.00	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	ARHGAP25	0.33	0.19	bslmm	573	0.24	5.2e-30	7.8	-7.3	2.9e-13	0.02	0.00	1.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	TGFA	0.09	0.03	bslmm	191	0.04	7.4e-06	-2.2	-5.8	5.5e-09	0.29	0.86	0.05	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	GFPT1	0.09	0.01	bslmm	439	0.02	3.2e-04	2.9	5.5	4.3e-08	-0.28	0.31	0.05	FALSE
38	YFS	Blood	PCYOX1	0.02	0.01	blup	461	0.01	1.1e-05	-8.3	9.1	7.6e-20	-0.39	0.45	0.41	FALSE
39	YFS	Blood	SNRNP27	0.05	0.05	bslmm	332	0.05	9.5e-17	-14.0	13.5	2.8e-41	-0.82	0.04	0.96	TRUE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	ANXA4	0.01	0.01	blup	58	0.01	2.3e-03	6.2	10.4	2.6e-25	-0.58	0.06	0.33	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	ASPRV1	0.01	0.01	blup	58	0.01	1.1e-03	2.3	-6.3	2.8e-10	0.29	0.06	0.11	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNRNP27	0.02	0.00	enet	5	0.01	2.5e-03	2.7	9.9	3.0e-23	-0.68	0.01	0.40	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GMCL1	0.03	0.03	blup	46	0.02	5.7e-03	-8.6	-6.5	5.8e-11	0.32	0.27	0.04	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANXA4	0.10	0.10	lasso	5	0.12	1.8e-13	-6.5	8.1	8.3e-16	-0.43	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM136A	0.04	0.03	blup	42	0.04	6.0e-05	-6.9	6.4	1.6e-10	-0.33	0.01	0.98	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNRNP27	0.09	0.02	blup	31	0.05	4.4e-06	2.0	9.2	3.3e-20	-0.65	0.50	0.48	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM136A	0.07	0.03	lasso	3	0.04	1.6e-03	-7.0	6.1	9.7e-10	-0.29	0.01	0.87	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf42	0.04	0.01	blup	46	0.02	1.1e-03	-8.2	5.3	1.3e-07	-0.29	0.01	0.80	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	FAM136A	0.04	0.03	blup	42	0.03	1.2e-04	-4.8	5.6	2.1e-08	-0.29	0.02	0.97	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	SNRNP27	0.06	0.06	enet	3	0.04	9.5e-06	2.8	7.1	1.5e-12	-0.52	0.80	0.13	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNRNP27	0.05	0.01	enet	3	0.03	1.7e-04	-14.4	12.3	6.1e-35	-0.88	0.00	0.98	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNRNP27	0.09	0.01	blup	31	0.03	5.1e-04	2.7	11.4	5.7e-30	-0.76	0.01	0.58	FALSE
53	The Cancer Genome Atlas	Soft Tissue Sarcoma	C2orf42	0.12	0.03	enet	17	0.05	1.0e-03	-4.9	5.9	4.0e-09	-0.23	0.04	0.12	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	FAM136A	0.04	0.04	lasso	4	0.04	8.5e-04	-6.9	6.5	6.0e-11	-0.33	0.01	0.90	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	FAM136A	0.05	0.04	lasso	3	0.04	4.5e-05	-5.0	6.0	1.7e-09	-0.30	0.02	0.98	FALSE