Hub : Genes

TGFA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0270	5.5e-08	0.102	0.083	0.116	0.096	0.115	2.4e-12	2.4e-10	5.5e-14	1.1e-11	8.3e-14
2	GTEx	Nerve Tibial	0.0941	0.0404	6.9e-03	0.053	NA	0.016	NA	0.025	1.2e-04	NA	2.6e-02	NA	6.2e-03
3	GTEx	Testis	0.6210	0.0550	0.0e+00	0.621	NA	0.640	NA	0.639	1.7e-34	NA	3.2e-36	NA	4.2e-36
4	ROSMAP	Brain Pre-frontal Cortex	0.0919	0.0355	2.4e-05	0.031	0.036	0.038	0.039	0.031	7.1e-05	1.8e-05	9.4e-06	7.4e-06	6.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	1.6	1.0	1.3	-0.1	1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	0.6	1.5	-0.3	1.1
Depressed Affect (Nagel 2018)	0.9	1.9	2.4	-1.6	-1.5	1.5	-0.8
Depression (Nagel 2018)	0.3	0.4	1.5	-0.1	0.1	0.4	1.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.3	-0.0	0.1	-1.8	1.1
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.6	-1.0	0.0	0.1
Schizophrenia (2018)	0.1	0.3	0.8	-0.0	0.9	-0.3	0.6
Schizophrenia vs Biploar Disorder	1.4	1.8	5.6	0.9	2.4	-1.0	0.1
Worry (Nagel 2018)	0.4	0.8	2.0	1.4	0.2	-0.9	0.7
Alzheimer’s Disease (in mother)	1.8	2.1	3.6	1.6	1.9	-1.2	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.9	-0.0	-0.2	0.3	-0.9
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	0.9	1.5	-0.9	-0.4
Crohns Disease (2017)	0.2	0.3	0.9	0.9	0.2	0.3	0.6
Irritable Bowel Disease (IBD)	0.5	1.2	2.4	1.4	0.5	-0.2	1.6
Ulcerative Colitis (UC)	0.5	0.9	2.6	0.8	0.6	-0.1	1.6
Major Depression (MDD)	1.8	2.2	3.7	-1.5	-1.9	1.7	-0.2
Reaction Time	0.8	1.6	4.6	-1.0	-0.6	0.6	-2.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.4	0.3	0.6	-2.1	1.3
Breast Cancer	3.4	8.2	17.1	1.4	3.5	-1.2	4.1
Ovarian Cancer	0.2	0.2	0.6	-0.3	0.5	-0.8	0.1
Prostate Cancer	2.8	3.9	5.7	-2.2	-2.4	1.4	-1.7
Age at First Birth	2.7	4.0	10.1	-3.2	-0.9	2.2	0.2
Bipolar Disorder (2011)	2.3	2.2	4.5	1.1	1.7	-0.7	2.1
Body Mass Index (BMI) (2010)	0.6	0.9	1.8	-1.2	-0.4	1.3	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.6	-0.5	-0.2	0.5	-1.3
Crohns Disease (2012)	1.0	1.6	4.2	0.8	1.0	-0.7	2.1
Mean Putamen Volume	1.4	1.6	2.3	-1.4	-1.5	1.3	-0.7
Fasting Glucose	0.3	0.4	0.6	0.4	0.5	-0.7	-0.8
HbA1C	0.5	0.6	1.6	1.3	-0.2	-0.7	-0.4
HDL Cholesterol	0.3	0.5	0.7	-0.8	0.5	0.5	0.8
LDL Cholesterol	1.3	2.1	3.2	1.2	1.7	-0.9	1.8
Lupus	0.1	0.1	0.2	0.5	0.3	0.4	0.0
Neuroticism (2016)	1.6	2.3	4.6	1.5	0.7	-1.4	2.2
Primary Biliary Cirrhosis	0.4	0.6	1.8	1.3	0.0	-0.2	-0.7
Rheumatoid Arthritis	1.0	1.4	3.3	-0.3	0.5	1.8	1.3
Schizophrenia (2014)	1.1	2.4	5.6	1.0	2.4	-1.3	1.3
Triglycerides	0.1	0.2	0.8	0.1	-0.4	-0.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.4	0.6	0.6	0.0
Ulcerative Colitis	0.4	0.6	2.2	0.5	-0.2	-0.1	1.5
Blood Eosinophil Count	0.1	1.1	2.5	0.6	1.0	-1.6	0.9
Blood Platelet Count	1.2	14.0	34.0	-2.5	-3.9	-0.8	-5.8
Blood Red Count	0.4	3.5	10.1	1.1	0.0	-1.7	-3.2
Blood White Count	0.3	2.0	3.5	-1.9	-1.8	0.4	1.1
Heel T-Score	1.1	8.6	16.4	-4.0	-0.6	3.0	-2.9
BMI	1.1	6.6	11.6	-3.4	-2.2	2.9	-1.1
Height	0.0	0.8	1.4	1.1	-0.2	-1.2	0.7
Waist Hip Ratio (WHR)	0.2	0.9	3.1	1.8	0.5	-0.3	-0.1
Systolic Blood Pressure	0.1	0.5	0.9	0.9	0.5	-0.6	-0.6
Smoking Status	0.1	0.2	0.3	-0.3	0.5	-0.2	0.6
Allergy or Eczema	2.2	5.7	7.5	2.3	2.7	-2.7	1.6
Cardiovascular Disease	0.2	0.5	0.7	-0.5	-0.6	0.8	-0.9
Hypothyroidism (self reported)	0.2	0.5	0.7	-0.8	-0.8	0.7	-0.3
Respiratory disease	1.0	2.3	4.4	1.8	-0.2	-2.1	1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	-1.0	0.0	1.4	-0.6
Lung FEV1/FVC ratio	1.1	5.5	7.8	-1.4	-2.7	2.8	-2.3
Lung FVC	0.1	0.6	2.0	-0.6	0.2	-1.4	-0.2
Neuroticism	0.1	0.3	0.7	-0.1	-0.8	0.4	-0.5
Chronotype (morning person)	0.4	0.9	1.8	1.1	1.4	-0.5	0.5
Hair Pigment	0.2	4.4	9.6	1.2	1.6	2.0	3.1
Tanning	0.0	0.1	0.1	0.2	0.1	0.4	-0.4
Hand grip strength (left)	19.1	50.2	66.1	7.8	6.2	-5.9	8.1
Number of treatments/medications taken	1.2	2.1	2.8	-1.7	-1.6	1.0	-1.3
Average weekly spirits intake	0.2	0.2	0.5	0.6	0.0	0.7	-0.3
Sensitivity / hurt feelings	1.1	1.9	4.8	1.3	-0.1	-1.2	2.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.2
Hearing difficulty/problems: Yes	1.0	1.6	3.3	-0.5	-1.5	0.8	-1.8
Relative age of first facial hair	0.8	1.7	2.7	-1.2	-1.5	0.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.7	-0.2	0.3	0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	-1.0	-0.7	1.2	-0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.2	-0.2	0.5	-0.4
Systolic blood pressure, automated reading	0.0	0.1	0.1	0.3	0.3	-0.2	-0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.0	-0.3	-0.6	0.6
Angina	4.8	6.2	8.7	-2.7	-3.0	1.1	-2.8
Medication for hormone replacement therapy	1.0	1.1	3.2	1.8	0.6	-0.8	0.4
Vitamin and mineral supplements	0.7	1.0	2.4	-1.2	-0.2	1.6	-0.4
Supplements: Zinc	0.3	0.3	0.4	0.6	0.6	-0.7	-0.3
Medication: Co-codamol	3.2	3.7	6.9	-1.9	-1.5	1.4	-2.6
Medication: Metformin	0.7	1.0	2.1	-0.7	-1.5	1.2	-0.1
Diabetes (father)	2.0	2.5	7.6	2.8	0.2	-1.5	0.2
Diabetes (mother)	0.5	0.6	2.1	0.3	0.6	0.3	1.4
Severe depression (siblings)	0.2	0.2	0.7	0.3	-0.2	0.8	0.3
Pack years adult smoking proportion	0.3	0.5	1.0	-0.5	-0.7	0.3	-1.0
Impedance of leg (right)	0.7	3.4	6.2	2.5	1.6	-1.9	1.1
Leg fat-free mass (left)	0.2	1.1	2.8	-1.7	-0.6	0.9	0.4
Trunk fat percentage	1.0	3.9	6.0	-2.2	-2.1	2.4	-0.6
Hand grip strength (right)	19.9	54.2	71.4	8.4	6.5	-6.2	8.1
Townsend deprivation index at recruitment	1.8	2.5	3.4	-1.8	-1.3	1.3	-1.8
Current tobacco smoking	0.6	0.9	2.4	-1.0	-0.6	1.6	-0.1
Average weekly fortified wine intake	0.3	0.3	0.4	0.6	-0.5	-0.6	-0.5
Maternal smoking around birth	0.4	0.6	1.1	-0.5	-1.1	0.7	-0.8
Fed-up feelings	1.5	2.7	4.9	-2.2	-1.4	1.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.4	-0.5	-0.8	0.7
Relative age voice broke	0.7	1.1	1.7	-1.3	-1.3	0.8	-0.6
Taking other prescription medications	0.4	0.7	0.9	-0.8	-0.9	0.6	-0.9
Age when periods started (menarche)	0.4	1.0	1.7	-0.8	-0.3	1.2	-1.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.2	-0.7	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	10.0	-3.2	-0.4	2.6	-2.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.0	0.6	0.3	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.4	-0.8	-0.5	0.2
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.9	0.5	0.3	-0.6
High blood pressure	0.1	0.2	0.4	-0.1	-0.3	0.6	-0.6
Hayfever, allergic rhinitis or eczema	1.7	3.6	5.5	1.6	2.3	-2.1	1.3
Multivitamins +/- minerals	1.7	2.2	4.4	2.1	0.7	-1.9	0.1
Stomach or abdominal pain in last month	0.7	0.8	1.8	-0.2	-1.1	0.5	-1.3
Supplements: Glucosamine	2.7	3.5	7.8	-2.8	-0.5	2.1	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.6	0.2	0.7	0.5
Medication: Atenolol	0.5	0.6	1.8	-1.4	-0.6	0.3	0.4
Medication: Levothyroxine sodium	0.2	0.4	0.8	-0.9	-0.1	0.5	0.6
Sitting height	0.1	0.6	2.1	-1.4	-0.1	-0.4	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.3
High blood pressure (mother)	1.8	2.6	4.5	-2.0	-0.6	1.3	-2.1
Body mass index (BMI)	1.3	5.4	9.5	-3.1	-1.8	2.8	-1.2
Impedance of leg (left)	0.7	3.4	6.5	2.5	1.6	-1.8	1.1
Leg predicted mass (left)	0.2	1.1	2.9	-1.7	-0.6	1.0	0.4
Trunk fat mass	0.7	3.0	4.7	-2.2	-1.6	2.1	-0.1
Waist circumference	0.8	2.9	4.5	-2.0	-1.6	2.1	-0.6
Number of incorrect matches in round	0.6	1.1	2.4	1.5	0.2	-1.1	-0.8
Past tobacco smoking	0.0	0.0	0.1	0.1	-0.3	-0.2	0.1
Alcohol usually taken with meals	0.4	0.7	1.3	0.6	0.8	-1.1	0.6
Nervous feelings	0.0	0.1	0.1	0.2	0.3	-0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	-1.1	-1.4	-0.1	-1.2
Hearing difficulty/problems with background noise	1.4	2.3	3.0	-1.6	-1.6	0.9	-1.7
Hair/balding pattern: Pattern 2	1.0	1.2	3.1	0.5	0.6	-1.8	1.0
Had menopause	1.4	1.7	3.8	-0.7	-1.6	2.0	-0.1
Had other major operations	2.7	3.3	4.5	-1.2	-1.9	1.9	-2.1
Forced vital capacity (FVC)	1.0	3.9	7.2	1.0	1.9	-2.7	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	5.4	-2.3	0.1	1.9	-2.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.6	0.7	0.7	-1.2	1.2
Qualifications: None of the above	0.5	1.1	4.2	-0.1	-0.4	2.0	0.0
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.3	0.8	0.7	0.1
Mouth/teeth dental problems	1.1	1.6	3.0	0.5	1.7	-0.8	1.6
Heart attack	1.1	1.4	2.5	-1.0	-1.6	0.6	-1.2
Allergy	1.7	3.8	6.8	-2.3	-1.6	2.6	-0.8
Pain all over the body in last month	1.4	1.5	2.7	0.8	1.6	-1.2	1.0
Diabetes (self-reported)	0.4	0.6	1.8	-0.7	0.0	1.3	0.2
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.3	1.6	1.5	0.2	1.8
Medication: Ramipril	2.4	3.0	4.9	-1.5	-2.1	0.7	-2.2
Medication: Simvastatin	0.4	0.6	1.4	-0.4	-1.2	0.7	-0.5
Fluid intelligence score	0.3	0.7	1.8	0.1	-0.1	-1.4	0.9
Illnesses of siblings	0.3	0.5	0.8	0.3	0.5	-0.9	0.9
Neuroticism score	0.1	0.2	0.4	0.7	-0.3	-0.4	-0.3
Weight	0.5	2.4	5.7	-2.4	-1.1	1.7	-0.0
Impedance of arm (right)	0.2	1.2	2.7	1.6	0.1	-1.2	0.7
Arm fat percentage (right)	1.0	3.9	6.5	-2.5	-1.9	2.3	-0.7
Trunk fat-free mass	0.1	0.8	1.7	-0.6	1.1	-0.4	1.3
Hip circumference	0.9	4.0	8.1	-2.8	-1.7	2.1	-0.8
Time employed in main current job	0.2	0.2	0.5	-0.5	0.2	-0.0	0.7
Alcohol intake versus 10 years previously	0.2	0.2	0.5	0.5	0.7	0.0	0.4
Father’s age at death	1.1	1.5	3.1	-1.5	-0.7	1.8	-0.6
Worrier / anxious feelings	0.9	1.7	3.8	2.0	0.6	-1.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.9	-2.0	-1.0	0.7	-1.6
Falls in the last year	0.5	0.6	1.4	-1.2	-0.7	0.7	-0.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	0.9	0.6	-0.8	0.0
Number of live births	0.4	0.6	1.5	-0.8	-0.2	1.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.9	0.9	1.3	-2.2	1.4
Pulse rate	0.3	0.4	1.2	-0.0	-0.8	-1.1	-0.1
Happiness	1.3	1.5	2.5	0.6	1.5	-1.6	0.9
Noisy workplace	0.3	0.3	0.8	-0.4	-0.9	-0.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.2	0.1	0.9	-1.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.1	-0.6	-1.5	0.1
Mouth/teeth dental problems: Dentures	0.3	0.6	2.0	0.5	-1.4	0.2	-0.2
Asthma	1.9	3.7	5.7	2.4	1.5	-2.1	1.5
Medication: Ibuprofen (e.g. Nurofen)	4.3	5.5	8.7	-3.0	-2.1	1.9	-2.3
Medication: Cholesterol lowering	0.3	0.4	0.7	-0.9	-0.6	0.5	0.5
Depression (self-reported)	0.5	0.6	1.2	-0.0	-1.1	0.7	-0.8
Medication: Lansoprazole	1.4	1.6	2.3	-1.5	-1.2	1.3	-1.0
Prospective memory result	0.2	0.2	0.3	0.5	-0.5	0.3	-0.5
Lung cancer (father)	0.6	0.7	1.9	-0.1	-1.4	-0.3	-1.0
Illnesses of mother	2.6	3.3	5.0	1.7	0.9	-2.0	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.6	1.0	1.1	-2.4	1.1
Pulse wave Arterial Stiffness index	3.0	3.5	5.4	-2.2	-1.5	2.3	-1.2
Impedance of arm (left)	0.1	0.6	1.3	1.1	-0.4	-0.9	0.4
Arm fat mass (right)	0.7	2.8	5.5	-2.4	-1.3	2.0	-0.3
Trunk predicted mass	0.1	0.8	1.6	-0.6	1.1	-0.4	1.3
Standing height	0.3	2.8	6.0	0.9	1.3	-1.6	2.4
Length of working week for main job	0.3	0.4	1.1	0.3	0.6	-0.2	1.0
Exposure to tobacco smoke at home	5.1	5.7	8.3	-2.0	-2.6	1.9	-2.9
Breastfed as a baby	0.7	0.8	1.0	0.9	-0.8	-1.0	1.0
Tense / ‘highly strung’	0.5	0.9	2.0	0.2	-1.2	-0.1	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.3	-0.1	-0.1	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	0.6	-0.7	1.5	0.6
Birth weight of first child	0.5	1.0	1.4	1.1	1.2	0.2	1.1
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.4	-0.2	0.5	-0.1
Pulse wave reflection index	0.7	0.9	2.3	-1.0	0.5	1.5	-0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.6	1.6	0.6	-0.4	0.0
Loud music exposure frequency	8.8	9.7	15.1	3.1	3.9	-3.0	2.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	-0.0	0.5	-1.4	-0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.9	-0.1	-0.7	0.3	-1.4
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.2	-0.7	0.2	-0.9
Medication: Paracetamol	3.4	5.6	7.9	-2.8	-2.1	2.2	-2.2
Headache pain in last month	0.1	0.2	0.6	0.1	-0.8	0.1	-0.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.5	1.6	0.4	-1.5	-0.5
Glaucoma (self-reported)	2.0	2.4	4.7	-1.5	-0.9	2.2	-1.3
Gout (self-reported)	1.0	1.3	2.9	0.7	0.9	-1.7	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.4	-0.1	0.6	0.3
Medication: Amlodipine	0.2	0.3	0.6	-0.6	-0.8	0.1	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.6	0.2	-1.0	-0.2
Birth weight	1.1	2.3	5.4	1.0	0.8	-2.3	1.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.5	-1.2	-1.2	1.2	-1.1
High blood pressure (siblings)	0.1	0.2	0.5	0.5	0.1	0.1	-0.7
Forced vital capacity (FVC), Best measure	1.4	5.2	10.8	1.5	2.0	-3.3	2.0
Body fat percentage	0.8	3.3	5.0	-2.1	-1.8	2.2	-0.5
Leg fat percentage (right)	0.5	1.8	3.3	-1.7	-0.9	1.8	-0.2
Arm fat-free mass (right)	0.1	0.6	1.8	-1.3	0.1	0.6	0.5
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-0.3	-0.1	1.0	-0.4
Comparative body size at age 10	1.3	3.6	6.4	1.8	1.8	-1.2	2.5
Number of full brothers	0.5	0.6	1.2	1.1	0.9	-0.4	0.4
Worry too long after embarrassment	0.5	0.8	1.7	1.3	-0.5	-0.9	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	0.6	-1.2	0.5	-0.1
Wheeze or whistling in the chest in last year	0.9	1.7	3.5	1.2	1.2	-1.9	-0.4
Number of children fathered	0.2	0.3	0.4	0.5	0.7	0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	9.3	1.6	0.2	-3.0	0.5
Age at first live birth	0.8	1.4	3.4	0.6	1.2	-0.8	1.9
Pulse wave peak to peak time	3.8	4.5	7.3	2.4	1.6	-2.7	1.5
Health satisfaction	0.4	0.5	1.4	-0.8	-1.2	-0.1	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.5	0.1	-0.7	0.1	-0.0
Qualifications: College or University degree	0.3	0.8	2.4	-0.2	1.6	-0.3	0.9
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.3	-0.0	0.3	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.0	0.5	0.7	-0.7	1.0
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.4	-0.8	-0.1	0.3
Medication for pain relief, constipation, heartburn	6.2	10.7	12.5	3.5	3.1	-2.9	3.5
Neck or shoulder pain in last month	0.9	1.3	3.5	0.2	-0.8	1.0	-1.9
Medication: Blood pressure	0.3	0.6	1.1	-1.1	0.1	0.9	0.6
Angina (self-reported)	4.6	6.0	8.3	-2.8	-2.9	1.2	-2.5
Migraine (self-reported)	0.1	0.1	0.2	0.4	-0.4	0.2	0.3
Medication: Ibuprofen	3.8	4.5	9.7	-3.1	-1.6	2.0	-1.4
Medication: Allopurinol	2.1	2.8	6.7	1.1	1.3	-2.6	1.2
Medication: Omeprazole	2.1	2.5	3.7	-1.9	-0.6	1.9	-1.6
Medication: Seretide 50 evohaler	0.4	0.4	0.6	0.4	0.8	-0.8	0.7
Mean time to correctly identify matches	1.5	2.9	7.7	-1.0	-1.3	1.2	-2.8
Heart disease (mother)	2.3	2.9	6.4	-1.2	-1.5	1.2	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.1	-0.4	-1.5	-0.1	-2.0
Whole body fat mass	0.8	3.4	5.8	-2.4	-1.6	2.3	-0.2
Leg fat mass (right)	0.7	2.8	5.2	-2.3	-1.2	2.1	-0.3
Arm predicted mass (right)	0.1	0.5	1.3	-1.2	0.2	0.4	0.6
Pulse rate, automated reading	0.1	0.4	0.7	-0.2	-0.9	0.7	0.5
Alcohol intake frequency.	0.1	0.1	0.2	-0.3	-0.1	0.4	0.4
Comparative height size at age 10	0.4	2.2	3.3	1.5	1.2	-1.8	1.3
Number of full sisters	1.5	1.8	3.6	1.9	0.7	-0.8	1.6
Suffer from ‘nerves’	0.1	0.2	0.5	0.1	-0.7	-0.4	-0.3
Overall health rating	3.0	6.5	7.8	-2.8	-2.4	2.5	-2.5
Chest pain or discomfort	0.3	0.4	1.1	-0.1	-0.5	-1.0	-0.5
Had major operations	0.7	0.9	1.2	-1.1	0.4	1.1	1.0
Age at last live birth	1.6	2.4	4.0	0.9	1.8	-1.2	2.0
Family relationship satisfaction	1.1	1.3	3.0	1.1	0.8	-1.7	0.4
Leg pain on walking	2.0	2.5	4.1	-1.3	-2.0	0.5	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.5	-0.9	-1.2	-0.1	-2.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	0.5	0.9	-0.4	0.0
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.6	-1.0	-1.3	1.2	0.2
Medication: Aspirin	0.9	1.2	3.0	-0.6	-1.2	0.3	-1.7
Supplements: Vitamin C	0.6	0.7	1.4	0.6	0.8	-1.2	0.8
Knee pain experienced in last month	3.5	5.4	8.7	-2.9	-1.6	1.5	-2.8
Hypertension (Self-reported)	0.1	0.2	0.4	-0.1	-0.3	0.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.3	-1.1	-1.1	0.7	-0.9
Illnesses of father: Heart disease	0.5	0.7	1.9	-0.8	0.3	0.4	-1.4
Illnesses of siblings: Diabetes	0.1	0.2	0.6	0.0	0.3	0.8	-0.1
Smoking status: Previous	0.9	1.4	2.0	1.2	1.0	-1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-0.6	0.8	-0.4	1.1
Whole body fat-free mass	0.1	0.6	1.3	-1.1	0.3	0.3	0.9
Leg fat-free mass (right)	0.2	1.2	3.2	-1.8	-0.7	1.0	0.3
Arm fat percentage (left)	1.1	4.4	7.3	-2.7	-2.0	2.4	-0.8
Average weekly red wine intake	0.1	0.2	0.2	-0.5	0.5	0.2	0.4
Handedness (chirality/laterality): Left-handed	1.4	1.6	3.3	1.8	1.1	-1.3	0.6
Mood swings	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5
Loneliness, isolation	0.9	1.3	2.0	-1.2	-1.4	1.0	-0.9
Long-standing illness, disability or infirmity	3.4	5.1	6.7	-2.6	-2.4	1.5	-2.5
Ever had bowel cancer screening	0.9	1.0	2.1	-1.0	-0.9	1.4	-0.5
Diabetes diagnosed by doctor	0.3	0.6	1.6	-0.8	0.0	1.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	-0.4	0.3	-0.0
Friendships satisfaction	0.2	0.3	0.9	0.4	1.0	-0.4	-0.1
Qualifications: nursing, teaching	0.5	0.8	3.2	0.2	0.1	-1.8	-0.2
Commuting to job workplace: Walk	0.6	0.6	1.1	0.6	0.5	-0.8	1.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.4	0.6	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.0	-0.7	-0.7	0.4	-1.7
Medication for cholesterol	0.5	0.7	1.2	-1.0	1.1	0.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.7	-0.4	0.1	0.8
Back pain experienced in last month	0.7	1.1	3.5	-0.4	-0.5	0.7	-1.9
Mineral and other dietary supplements	0.3	0.4	1.2	0.5	-0.4	-1.1	-0.2
Breast cancer (self-reported)	0.3	0.3	0.7	0.4	-0.8	-0.2	-0.6
Asthma (self-reported)	1.6	3.2	4.8	2.2	1.2	-1.9	1.7
Osteoporosis (self-reported)	0.2	0.3	1.0	0.5	0.1	-0.1	1.0
Osteoarthritis (self-reported)	12.4	16.1	32.7	-5.7	-2.6	3.3	-3.7
Medication: Aspirin	0.5	0.6	1.9	-0.1	-0.8	0.2	-1.4
Medication: Gliclazide	1.2	1.4	3.5	-0.9	-1.1	1.9	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	-0.3	-0.4	1.0	0.4
Smoking status: Current	1.1	1.7	4.2	-1.3	-0.8	2.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.0	0.2	-0.7	0.1
Whole body water mass	0.1	0.6	1.4	-1.2	0.3	0.3	0.8
Leg predicted mass (right)	0.2	1.1	2.9	-1.7	-0.6	1.0	0.4
Arm fat mass (left)	0.7	3.1	6.1	-2.5	-1.5	2.0	-0.4
Number of self-reported non-cancer illnesses	4.2	7.3	9.9	-2.1	-3.0	3.1	-2.4
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.3	-0.6	-1.0	0.2
Miserableness	0.5	0.9	1.6	-1.3	-0.6	0.7	-1.0
Guilty feelings	0.4	0.5	1.4	1.2	0.1	-0.9	0.0
Wears glasses or contact lenses	1.0	1.1	2.3	-0.6	-1.5	0.3	-1.3
Ever taken oral contraceptive pill	3.1	3.4	6.8	0.9	2.3	-1.0	2.6
Hearing aid user	0.9	1.0	3.2	0.8	-1.8	-0.3	-0.2
Mother’s age at death	0.2	0.2	0.4	-0.5	0.6	0.2	-0.5
Financial situation satisfaction	1.2	1.5	3.1	1.1	1.1	-1.8	0.4
Tinnitus: Yes, now most or all of the time	4.4	5.2	9.2	-1.0	-2.7	1.7	-3.0
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.8	-0.3	-0.4	0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.3	-0.1	0.7	-0.4
Medication: Blood pressure	0.9	1.7	3.8	-0.0	-2.0	0.0	-1.8
Pain type(s) experienced in last month: Hip pain	1.9	2.5	4.4	-2.1	-0.1	1.4	-1.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	-0.7	-0.2	1.7	-0.6
High cholesterol (Self-reported)	1.6	2.8	4.9	-1.1	-2.2	1.8	-1.3
Medication: Bendroflumethiazide	0.3	0.5	0.9	0.9	-0.4	-0.4	0.8
Medication: Paracetamol	1.9	3.0	7.5	-2.7	-0.7	1.7	-1.0
Medication: Lisinopril	0.6	0.8	2.0	-1.4	-1.0	0.6	-0.0
Medication: Atorvastatin	0.4	0.4	1.2	-1.1	0.2	0.7	0.3
Illnesses of father: High blood pressure	0.4	0.5	0.9	-0.9	-0.8	0.0	-0.7
Alcohol drinker status: Never	0.6	0.7	1.5	-0.7	-1.2	0.3	-1.0
Ever smoked	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.2
Basal metabolic rate	0.1	0.8	2.3	-1.5	0.0	0.6	0.7
Leg fat percentage (left)	0.4	1.6	3.2	-1.5	-0.9	1.8	-0.2
Arm fat-free mass (left)	0.1	0.7	1.7	-1.3	0.1	0.7	0.7
Number of operations (self-reported)	1.9	2.8	3.2	-1.6	-1.6	1.6	-1.8
Average weekly beer plus cider intake	0.8	1.2	3.7	0.8	0.2	-0.5	1.9
Irritability	0.2	0.3	0.6	0.8	0.4	-0.6	0.1
Risk taking	0.1	0.1	0.3	0.2	0.3	0.5	-0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.7	-0.8	-0.5	0.8	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.7	0.4	-0.2	0.7
Age started oral contraceptive pill	0.2	0.2	0.3	-0.6	-0.3	0.3	-0.6
Diastolic blood pressure, automated reading	0.3	0.9	1.3	1.1	0.9	-0.9	0.8
Ever depressed for a whole week	0.0	0.0	0.1	-0.0	-0.3	-0.0	0.2
Unable to work because of sickness or disability	3.7	4.8	7.3	-1.7	-2.7	1.3	-2.7
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.0	-0.6	-0.4	0.6
Myopia	0.4	0.6	1.5	0.0	-0.9	1.2	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.7	0.5	0.8	-0.7	0.9
Cholesterol lowering medication	0.3	0.4	0.8	-0.5	-0.9	0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	4.3	-2.1	-1.0	1.5	-1.6
Pain experienced in last month	0.4	0.7	1.4	0.7	0.0	-1.0	1.2
Supplements: Calcium	0.2	0.2	0.7	0.1	0.3	0.4	0.9
Basal cell carcinoma (self-reported)	2.6	3.1	6.2	2.2	1.1	-2.5	0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.3	-0.9	-1.5	0.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.2	-0.5	0.2	-0.8
Heart disease (siblings)	0.4	0.5	1.2	0.5	0.4	-0.7	-1.1
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.5	0.5	0.3	0.6
Pack years of smoking	0.5	0.7	1.4	-0.5	-0.9	0.6	-1.2
Impedance of whole body	0.3	1.4	3.3	1.8	0.2	-1.4	0.6
Leg fat mass (left)	0.7	2.7	4.8	-2.2	-1.2	2.1	-0.3
Arm predicted mass (left)	0.1	0.6	1.8	-1.4	0.1	0.6	0.5