Hub : Genes

TGFA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1070 0.0270 5.5e-08 0.102 0.083 0.116 0.096 0.115 2.4e-12 2.4e-10 5.5e-14 1.1e-11 8.3e-14
2 GTEx Nerve Tibial 0.0941 0.0404 6.9e-03 0.053 NA 0.016 NA 0.025 1.2e-04 NA 2.6e-02 NA 6.2e-03
3 GTEx Testis 0.6210 0.0550 0.0e+00 0.621 NA 0.640 NA 0.639 1.7e-34 NA 3.2e-36 NA 4.2e-36
4 ROSMAP Brain Pre-frontal Cortex 0.0919 0.0355 2.4e-05 0.031 0.036 0.038 0.039 0.031 7.1e-05 1.8e-05 9.4e-06 7.4e-06 6.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 1.0 1.6 1.0 1.3 -0.1 1.1
Bipolar Disorder or Schizophrenia 0.4 1.0 2.2 0.6 1.5 -0.3 1.1
Depressed Affect (Nagel 2018) 0.9 1.9 2.4 -1.6 -1.5 1.5 -0.8
Depression (Nagel 2018) 0.3 0.4 1.5 -0.1 0.1 0.4 1.2
Intelligence (Savage-Jansen 2018) 0.4 1.1 3.3 -0.0 0.1 -1.8 1.1
Neuroticism (Nagel 2018) 0.1 0.3 0.9 0.6 -1.0 0.0 0.1
Schizophrenia (2018) 0.1 0.3 0.8 -0.0 0.9 -0.3 0.6
Schizophrenia vs Biploar Disorder 1.4 1.8 5.6 0.9 2.4 -1.0 0.1
Worry (Nagel 2018) 0.4 0.8 2.0 1.4 0.2 -0.9 0.7
Alzheimer’s Disease (in mother) 1.8 2.1 3.6 1.6 1.9 -1.2 0.8
Alzheimer’s Disease (in father) 0.2 0.2 0.9 -0.0 -0.2 0.3 -0.9
Alzheimer’s Disease (including proxy) 0.7 1.0 2.3 0.9 1.5 -0.9 -0.4
Crohns Disease (2017) 0.2 0.3 0.9 0.9 0.2 0.3 0.6
Irritable Bowel Disease (IBD) 0.5 1.2 2.4 1.4 0.5 -0.2 1.6
Ulcerative Colitis (UC) 0.5 0.9 2.6 0.8 0.6 -0.1 1.6
Major Depression (MDD) 1.8 2.2 3.7 -1.5 -1.9 1.7 -0.2
Reaction Time 0.8 1.6 4.6 -1.0 -0.6 0.6 -2.2
Verbal and Numeric Reasoning (VNR) 0.7 1.6 4.4 0.3 0.6 -2.1 1.3
Breast Cancer 3.4 8.2 17.1 1.4 3.5 -1.2 4.1
Ovarian Cancer 0.2 0.2 0.6 -0.3 0.5 -0.8 0.1
Prostate Cancer 2.8 3.9 5.7 -2.2 -2.4 1.4 -1.7
Age at First Birth 2.7 4.0 10.1 -3.2 -0.9 2.2 0.2
Bipolar Disorder (2011) 2.3 2.2 4.5 1.1 1.7 -0.7 2.1
Body Mass Index (BMI) (2010) 0.6 0.9 1.8 -1.2 -0.4 1.3 -0.2
Coronary Artery Disease (CAD) 0.4 0.5 1.6 -0.5 -0.2 0.5 -1.3
Crohns Disease (2012) 1.0 1.6 4.2 0.8 1.0 -0.7 2.1
Mean Putamen Volume 1.4 1.6 2.3 -1.4 -1.5 1.3 -0.7
Fasting Glucose 0.3 0.4 0.6 0.4 0.5 -0.7 -0.8
HbA1C 0.5 0.6 1.6 1.3 -0.2 -0.7 -0.4
HDL Cholesterol 0.3 0.5 0.7 -0.8 0.5 0.5 0.8
LDL Cholesterol 1.3 2.1 3.2 1.2 1.7 -0.9 1.8
Lupus 0.1 0.1 0.2 0.5 0.3 0.4 0.0
Neuroticism (2016) 1.6 2.3 4.6 1.5 0.7 -1.4 2.2
Primary Biliary Cirrhosis 0.4 0.6 1.8 1.3 0.0 -0.2 -0.7
Rheumatoid Arthritis 1.0 1.4 3.3 -0.3 0.5 1.8 1.3
Schizophrenia (2014) 1.1 2.4 5.6 1.0 2.4 -1.3 1.3
Triglycerides 0.1 0.2 0.8 0.1 -0.4 -0.1 -0.9
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 -0.4 0.6 0.6 0.0
Ulcerative Colitis 0.4 0.6 2.2 0.5 -0.2 -0.1 1.5
Blood Eosinophil Count 0.1 1.1 2.5 0.6 1.0 -1.6 0.9
Blood Platelet Count 1.2 14.0 34.0 -2.5 -3.9 -0.8 -5.8
Blood Red Count 0.4 3.5 10.1 1.1 0.0 -1.7 -3.2
Blood White Count 0.3 2.0 3.5 -1.9 -1.8 0.4 1.1
Heel T-Score 1.1 8.6 16.4 -4.0 -0.6 3.0 -2.9
BMI 1.1 6.6 11.6 -3.4 -2.2 2.9 -1.1
Height 0.0 0.8 1.4 1.1 -0.2 -1.2 0.7
Waist Hip Ratio (WHR) 0.2 0.9 3.1 1.8 0.5 -0.3 -0.1
Systolic Blood Pressure 0.1 0.5 0.9 0.9 0.5 -0.6 -0.6
Smoking Status 0.1 0.2 0.3 -0.3 0.5 -0.2 0.6
Allergy or Eczema 2.2 5.7 7.5 2.3 2.7 -2.7 1.6
Cardiovascular Disease 0.2 0.5 0.7 -0.5 -0.6 0.8 -0.9
Hypothyroidism (self reported) 0.2 0.5 0.7 -0.8 -0.8 0.7 -0.3
Respiratory disease 1.0 2.3 4.4 1.8 -0.2 -2.1 1.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.1 -1.0 0.0 1.4 -0.6
Lung FEV1/FVC ratio 1.1 5.5 7.8 -1.4 -2.7 2.8 -2.3
Lung FVC 0.1 0.6 2.0 -0.6 0.2 -1.4 -0.2
Neuroticism 0.1 0.3 0.7 -0.1 -0.8 0.4 -0.5
Chronotype (morning person) 0.4 0.9 1.8 1.1 1.4 -0.5 0.5
Hair Pigment 0.2 4.4 9.6 1.2 1.6 2.0 3.1
Tanning 0.0 0.1 0.1 0.2 0.1 0.4 -0.4
Hand grip strength (left) 19.1 50.2 66.1 7.8 6.2 -5.9 8.1
Number of treatments/medications taken 1.2 2.1 2.8 -1.7 -1.6 1.0 -1.3
Average weekly spirits intake 0.2 0.2 0.5 0.6 0.0 0.7 -0.3
Sensitivity / hurt feelings 1.1 1.9 4.8 1.3 -0.1 -1.2 2.2
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.1 -0.3 -0.0 0.1 -0.2
Hearing difficulty/problems: Yes 1.0 1.6 3.3 -0.5 -1.5 0.8 -1.8
Relative age of first facial hair 0.8 1.7 2.7 -1.2 -1.5 0.7 -1.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.5 -0.7 -0.2 0.3 0.6
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.4 -1.0 -0.7 1.2 -0.4
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.2 -0.2 0.5 -0.4
Systolic blood pressure, automated reading 0.0 0.1 0.1 0.3 0.3 -0.2 -0.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 0.0 -0.3 -0.6 0.6
Angina 4.8 6.2 8.7 -2.7 -3.0 1.1 -2.8
Medication for hormone replacement therapy 1.0 1.1 3.2 1.8 0.6 -0.8 0.4
Vitamin and mineral supplements 0.7 1.0 2.4 -1.2 -0.2 1.6 -0.4
Supplements: Zinc 0.3 0.3 0.4 0.6 0.6 -0.7 -0.3
Medication: Co-codamol 3.2 3.7 6.9 -1.9 -1.5 1.4 -2.6
Medication: Metformin 0.7 1.0 2.1 -0.7 -1.5 1.2 -0.1
Diabetes (father) 2.0 2.5 7.6 2.8 0.2 -1.5 0.2
Diabetes (mother) 0.5 0.6 2.1 0.3 0.6 0.3 1.4
Severe depression (siblings) 0.2 0.2 0.7 0.3 -0.2 0.8 0.3
Pack years adult smoking proportion 0.3 0.5 1.0 -0.5 -0.7 0.3 -1.0
Impedance of leg (right) 0.7 3.4 6.2 2.5 1.6 -1.9 1.1
Leg fat-free mass (left) 0.2 1.1 2.8 -1.7 -0.6 0.9 0.4
Trunk fat percentage 1.0 3.9 6.0 -2.2 -2.1 2.4 -0.6
Hand grip strength (right) 19.9 54.2 71.4 8.4 6.5 -6.2 8.1
Townsend deprivation index at recruitment 1.8 2.5 3.4 -1.8 -1.3 1.3 -1.8
Current tobacco smoking 0.6 0.9 2.4 -1.0 -0.6 1.6 -0.1
Average weekly fortified wine intake 0.3 0.3 0.4 0.6 -0.5 -0.6 -0.5
Maternal smoking around birth 0.4 0.6 1.1 -0.5 -1.1 0.7 -0.8
Fed-up feelings 1.5 2.7 4.9 -2.2 -1.4 1.9 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.6 0.4 -0.5 -0.8 0.7
Relative age voice broke 0.7 1.1 1.7 -1.3 -1.3 0.8 -0.6
Taking other prescription medications 0.4 0.7 0.9 -0.8 -0.9 0.6 -0.9
Age when periods started (menarche) 0.4 1.0 1.7 -0.8 -0.3 1.2 -1.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 0.2 -0.7 0.4 0.1
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.2 10.0 -3.2 -0.4 2.6 -2.0
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.4 0.0 0.6 0.3 -0.3
Qualifications: CSEs or equivalent 0.2 0.3 0.7 0.4 -0.8 -0.5 0.2
Serious illness, injury or assault to yourself 0.3 0.4 0.8 -0.9 0.5 0.3 -0.6
High blood pressure 0.1 0.2 0.4 -0.1 -0.3 0.6 -0.6
Hayfever, allergic rhinitis or eczema 1.7 3.6 5.5 1.6 2.3 -2.1 1.3
Multivitamins +/- minerals 1.7 2.2 4.4 2.1 0.7 -1.9 0.1
Stomach or abdominal pain in last month 0.7 0.8 1.8 -0.2 -1.1 0.5 -1.3
Supplements: Glucosamine 2.7 3.5 7.8 -2.8 -0.5 2.1 -1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.5 0.6 0.2 0.7 0.5
Medication: Atenolol 0.5 0.6 1.8 -1.4 -0.6 0.3 0.4
Medication: Levothyroxine sodium 0.2 0.4 0.8 -0.9 -0.1 0.5 0.6
Sitting height 0.1 0.6 2.1 -1.4 -0.1 -0.4 0.1
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.1 0.3 -0.1 -0.3
High blood pressure (mother) 1.8 2.6 4.5 -2.0 -0.6 1.3 -2.1
Body mass index (BMI) 1.3 5.4 9.5 -3.1 -1.8 2.8 -1.2
Impedance of leg (left) 0.7 3.4 6.5 2.5 1.6 -1.8 1.1
Leg predicted mass (left) 0.2 1.1 2.9 -1.7 -0.6 1.0 0.4
Trunk fat mass 0.7 3.0 4.7 -2.2 -1.6 2.1 -0.1
Waist circumference 0.8 2.9 4.5 -2.0 -1.6 2.1 -0.6
Number of incorrect matches in round 0.6 1.1 2.4 1.5 0.2 -1.1 -0.8
Past tobacco smoking 0.0 0.0 0.1 0.1 -0.3 -0.2 0.1
Alcohol usually taken with meals 0.4 0.7 1.3 0.6 0.8 -1.1 0.6
Nervous feelings 0.0 0.1 0.1 0.2 0.3 -0.4 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.8 -1.1 -1.4 -0.1 -1.2
Hearing difficulty/problems with background noise 1.4 2.3 3.0 -1.6 -1.6 0.9 -1.7
Hair/balding pattern: Pattern 2 1.0 1.2 3.1 0.5 0.6 -1.8 1.0
Had menopause 1.4 1.7 3.8 -0.7 -1.6 2.0 -0.1
Had other major operations 2.7 3.3 4.5 -1.2 -1.9 1.9 -2.1
Forced vital capacity (FVC) 1.0 3.9 7.2 1.0 1.9 -2.7 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 5.4 -2.3 0.1 1.9 -2.0
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.6 0.7 0.7 -1.2 1.2
Qualifications: None of the above 0.5 1.1 4.2 -0.1 -0.4 2.0 0.0
Financial difficulties in last 2 years 0.2 0.3 0.6 -0.3 0.8 0.7 0.1
Mouth/teeth dental problems 1.1 1.6 3.0 0.5 1.7 -0.8 1.6
Heart attack 1.1 1.4 2.5 -1.0 -1.6 0.6 -1.2
Allergy 1.7 3.8 6.8 -2.3 -1.6 2.6 -0.8
Pain all over the body in last month 1.4 1.5 2.7 0.8 1.6 -1.2 1.0
Diabetes (self-reported) 0.4 0.6 1.8 -0.7 0.0 1.3 0.2
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 3.3 1.6 1.5 0.2 1.8
Medication: Ramipril 2.4 3.0 4.9 -1.5 -2.1 0.7 -2.2
Medication: Simvastatin 0.4 0.6 1.4 -0.4 -1.2 0.7 -0.5
Fluid intelligence score 0.3 0.7 1.8 0.1 -0.1 -1.4 0.9
Illnesses of siblings 0.3 0.5 0.8 0.3 0.5 -0.9 0.9
Neuroticism score 0.1 0.2 0.4 0.7 -0.3 -0.4 -0.3
Weight 0.5 2.4 5.7 -2.4 -1.1 1.7 -0.0
Impedance of arm (right) 0.2 1.2 2.7 1.6 0.1 -1.2 0.7
Arm fat percentage (right) 1.0 3.9 6.5 -2.5 -1.9 2.3 -0.7
Trunk fat-free mass 0.1 0.8 1.7 -0.6 1.1 -0.4 1.3
Hip circumference 0.9 4.0 8.1 -2.8 -1.7 2.1 -0.8
Time employed in main current job 0.2 0.2 0.5 -0.5 0.2 -0.0 0.7
Alcohol intake versus 10 years previously 0.2 0.2 0.5 0.5 0.7 0.0 0.4
Father’s age at death 1.1 1.5 3.1 -1.5 -0.7 1.8 -0.6
Worrier / anxious feelings 0.9 1.7 3.8 2.0 0.6 -1.5 0.6
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 3.9 -2.0 -1.0 0.7 -1.6
Falls in the last year 0.5 0.6 1.4 -1.2 -0.7 0.7 -0.2
Hair/balding pattern: Pattern 3 0.3 0.5 0.9 0.9 0.6 -0.8 0.0
Number of live births 0.4 0.6 1.5 -0.8 -0.2 1.2 0.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 4.9 0.9 1.3 -2.2 1.4
Pulse rate 0.3 0.4 1.2 -0.0 -0.8 -1.1 -0.1
Happiness 1.3 1.5 2.5 0.6 1.5 -1.6 0.9
Noisy workplace 0.3 0.3 0.8 -0.4 -0.9 -0.2 -0.6
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.2 0.1 0.9 -1.1 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.4 -0.1 -0.6 -1.5 0.1
Mouth/teeth dental problems: Dentures 0.3 0.6 2.0 0.5 -1.4 0.2 -0.2
Asthma 1.9 3.7 5.7 2.4 1.5 -2.1 1.5
Medication: Ibuprofen (e.g. Nurofen) 4.3 5.5 8.7 -3.0 -2.1 1.9 -2.3
Medication: Cholesterol lowering 0.3 0.4 0.7 -0.9 -0.6 0.5 0.5
Depression (self-reported) 0.5 0.6 1.2 -0.0 -1.1 0.7 -0.8
Medication: Lansoprazole 1.4 1.6 2.3 -1.5 -1.2 1.3 -1.0
Prospective memory result 0.2 0.2 0.3 0.5 -0.5 0.3 -0.5
Lung cancer (father) 0.6 0.7 1.9 -0.1 -1.4 -0.3 -1.0
Illnesses of mother 2.6 3.3 5.0 1.7 0.9 -2.0 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 5.6 1.0 1.1 -2.4 1.1
Pulse wave Arterial Stiffness index 3.0 3.5 5.4 -2.2 -1.5 2.3 -1.2
Impedance of arm (left) 0.1 0.6 1.3 1.1 -0.4 -0.9 0.4
Arm fat mass (right) 0.7 2.8 5.5 -2.4 -1.3 2.0 -0.3
Trunk predicted mass 0.1 0.8 1.6 -0.6 1.1 -0.4 1.3
Standing height 0.3 2.8 6.0 0.9 1.3 -1.6 2.4
Length of working week for main job 0.3 0.4 1.1 0.3 0.6 -0.2 1.0
Exposure to tobacco smoke at home 5.1 5.7 8.3 -2.0 -2.6 1.9 -2.9
Breastfed as a baby 0.7 0.8 1.0 0.9 -0.8 -1.0 1.0
Tense / ‘highly strung’ 0.5 0.9 2.0 0.2 -1.2 -0.1 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.3 -0.1 -0.1 0.3
Hair/balding pattern: Pattern 4 0.3 0.8 2.1 0.6 -0.7 1.5 0.6
Birth weight of first child 0.5 1.0 1.4 1.1 1.2 0.2 1.1
Peak expiratory flow (PEF) 0.1 0.1 0.3 -0.4 -0.2 0.5 -0.1
Pulse wave reflection index 0.7 0.9 2.3 -1.0 0.5 1.5 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.6 1.6 0.6 -0.4 0.0
Loud music exposure frequency 8.8 9.7 15.1 3.1 3.9 -3.0 2.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.8 -0.0 0.5 -1.4 -0.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.9 -0.1 -0.7 0.3 -1.4
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.2 -0.7 0.2 -0.9
Medication: Paracetamol 3.4 5.6 7.9 -2.8 -2.1 2.2 -2.2
Headache pain in last month 0.1 0.2 0.6 0.1 -0.8 0.1 -0.5
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.5 1.6 0.4 -1.5 -0.5
Glaucoma (self-reported) 2.0 2.4 4.7 -1.5 -0.9 2.2 -1.3
Gout (self-reported) 1.0 1.3 2.9 0.7 0.9 -1.7 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 -0.4 -0.1 0.6 0.3
Medication: Amlodipine 0.2 0.3 0.6 -0.6 -0.8 0.1 -0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.6 0.2 -1.0 -0.2
Birth weight 1.1 2.3 5.4 1.0 0.8 -2.3 1.5
Chronic bronchitis/emphysema (mother) 1.2 1.4 1.5 -1.2 -1.2 1.2 -1.1
High blood pressure (siblings) 0.1 0.2 0.5 0.5 0.1 0.1 -0.7
Forced vital capacity (FVC), Best measure 1.4 5.2 10.8 1.5 2.0 -3.3 2.0
Body fat percentage 0.8 3.3 5.0 -2.1 -1.8 2.2 -0.5
Leg fat percentage (right) 0.5 1.8 3.3 -1.7 -0.9 1.8 -0.2
Arm fat-free mass (right) 0.1 0.6 1.8 -1.3 0.1 0.6 0.5
Exposure to tobacco smoke outside home 0.2 0.3 1.0 -0.3 -0.1 1.0 -0.4
Comparative body size at age 10 1.3 3.6 6.4 1.8 1.8 -1.2 2.5
Number of full brothers 0.5 0.6 1.2 1.1 0.9 -0.4 0.4
Worry too long after embarrassment 0.5 0.8 1.7 1.3 -0.5 -0.9 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.5 0.6 -1.2 0.5 -0.1
Wheeze or whistling in the chest in last year 0.9 1.7 3.5 1.2 1.2 -1.9 -0.4
Number of children fathered 0.2 0.3 0.4 0.5 0.7 0.5 0.3
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.0 9.3 1.6 0.2 -3.0 0.5
Age at first live birth 0.8 1.4 3.4 0.6 1.2 -0.8 1.9
Pulse wave peak to peak time 3.8 4.5 7.3 2.4 1.6 -2.7 1.5
Health satisfaction 0.4 0.5 1.4 -0.8 -1.2 -0.1 -0.2
Shortness of breath walking on level ground 0.1 0.1 0.5 0.1 -0.7 0.1 -0.0
Qualifications: College or University degree 0.3 0.8 2.4 -0.2 1.6 -0.3 0.9
Eye problems/disorders: None of the above 0.0 0.0 0.1 0.3 -0.0 0.3 -0.0
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.0 0.5 0.7 -0.7 1.0
Emphysema/chronic bronchitis 0.2 0.2 0.7 -0.4 -0.8 -0.1 0.3
Medication for pain relief, constipation, heartburn 6.2 10.7 12.5 3.5 3.1 -2.9 3.5
Neck or shoulder pain in last month 0.9 1.3 3.5 0.2 -0.8 1.0 -1.9
Medication: Blood pressure 0.3 0.6 1.1 -1.1 0.1 0.9 0.6
Angina (self-reported) 4.6 6.0 8.3 -2.8 -2.9 1.2 -2.5
Migraine (self-reported) 0.1 0.1 0.2 0.4 -0.4 0.2 0.3
Medication: Ibuprofen 3.8 4.5 9.7 -3.1 -1.6 2.0 -1.4
Medication: Allopurinol 2.1 2.8 6.7 1.1 1.3 -2.6 1.2
Medication: Omeprazole 2.1 2.5 3.7 -1.9 -0.6 1.9 -1.6
Medication: Seretide 50 evohaler 0.4 0.4 0.6 0.4 0.8 -0.8 0.7
Mean time to correctly identify matches 1.5 2.9 7.7 -1.0 -1.3 1.2 -2.8
Heart disease (mother) 2.3 2.9 6.4 -1.2 -1.5 1.2 -2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 4.1 -0.4 -1.5 -0.1 -2.0
Whole body fat mass 0.8 3.4 5.8 -2.4 -1.6 2.3 -0.2
Leg fat mass (right) 0.7 2.8 5.2 -2.3 -1.2 2.1 -0.3
Arm predicted mass (right) 0.1 0.5 1.3 -1.2 0.2 0.4 0.6
Pulse rate, automated reading 0.1 0.4 0.7 -0.2 -0.9 0.7 0.5
Alcohol intake frequency. 0.1 0.1 0.2 -0.3 -0.1 0.4 0.4
Comparative height size at age 10 0.4 2.2 3.3 1.5 1.2 -1.8 1.3
Number of full sisters 1.5 1.8 3.6 1.9 0.7 -0.8 1.6
Suffer from ‘nerves’ 0.1 0.2 0.5 0.1 -0.7 -0.4 -0.3
Overall health rating 3.0 6.5 7.8 -2.8 -2.4 2.5 -2.5
Chest pain or discomfort 0.3 0.4 1.1 -0.1 -0.5 -1.0 -0.5
Had major operations 0.7 0.9 1.2 -1.1 0.4 1.1 1.0
Age at last live birth 1.6 2.4 4.0 0.9 1.8 -1.2 2.0
Family relationship satisfaction 1.1 1.3 3.0 1.1 0.8 -1.7 0.4
Leg pain on walking 2.0 2.5 4.1 -1.3 -2.0 0.5 -1.9
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.5 -0.9 -1.2 -0.1 -2.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.8 0.5 0.9 -0.4 0.0
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.6 -1.0 -1.3 1.2 0.2
Medication: Aspirin 0.9 1.2 3.0 -0.6 -1.2 0.3 -1.7
Supplements: Vitamin C 0.6 0.7 1.4 0.6 0.8 -1.2 0.8
Knee pain experienced in last month 3.5 5.4 8.7 -2.9 -1.6 1.5 -2.8
Hypertension (Self-reported) 0.1 0.2 0.4 -0.1 -0.3 0.6 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.3 -1.1 -1.1 0.7 -0.9
Illnesses of father: Heart disease 0.5 0.7 1.9 -0.8 0.3 0.4 -1.4
Illnesses of siblings: Diabetes 0.1 0.2 0.6 0.0 0.3 0.8 -0.1
Smoking status: Previous 0.9 1.4 2.0 1.2 1.0 -1.4 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.2 -0.6 0.8 -0.4 1.1
Whole body fat-free mass 0.1 0.6 1.3 -1.1 0.3 0.3 0.9
Leg fat-free mass (right) 0.2 1.2 3.2 -1.8 -0.7 1.0 0.3
Arm fat percentage (left) 1.1 4.4 7.3 -2.7 -2.0 2.4 -0.8
Average weekly red wine intake 0.1 0.2 0.2 -0.5 0.5 0.2 0.4
Handedness (chirality/laterality): Left-handed 1.4 1.6 3.3 1.8 1.1 -1.3 0.6
Mood swings 0.1 0.2 0.3 0.4 -0.5 -0.4 -0.5
Loneliness, isolation 0.9 1.3 2.0 -1.2 -1.4 1.0 -0.9
Long-standing illness, disability or infirmity 3.4 5.1 6.7 -2.6 -2.4 1.5 -2.5
Ever had bowel cancer screening 0.9 1.0 2.1 -1.0 -0.9 1.4 -0.5
Diabetes diagnosed by doctor 0.3 0.6 1.6 -0.8 0.0 1.3 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 0.8 -0.4 0.3 -0.0
Friendships satisfaction 0.2 0.3 0.9 0.4 1.0 -0.4 -0.1
Qualifications: nursing, teaching 0.5 0.8 3.2 0.2 0.1 -1.8 -0.2
Commuting to job workplace: Walk 0.6 0.6 1.1 0.6 0.5 -0.8 1.1
Eye problems/disorders: Cataract 0.2 0.2 0.4 0.4 0.6 0.3 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.0 -0.7 -0.7 0.4 -1.7
Medication for cholesterol 0.5 0.7 1.2 -1.0 1.1 0.4 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.7 -0.4 0.1 0.8
Back pain experienced in last month 0.7 1.1 3.5 -0.4 -0.5 0.7 -1.9
Mineral and other dietary supplements 0.3 0.4 1.2 0.5 -0.4 -1.1 -0.2
Breast cancer (self-reported) 0.3 0.3 0.7 0.4 -0.8 -0.2 -0.6
Asthma (self-reported) 1.6 3.2 4.8 2.2 1.2 -1.9 1.7
Osteoporosis (self-reported) 0.2 0.3 1.0 0.5 0.1 -0.1 1.0
Osteoarthritis (self-reported) 12.4 16.1 32.7 -5.7 -2.6 3.3 -3.7
Medication: Aspirin 0.5 0.6 1.9 -0.1 -0.8 0.2 -1.4
Medication: Gliclazide 1.2 1.4 3.5 -0.9 -1.1 1.9 -0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 1.0 -0.3 -0.4 1.0 0.4
Smoking status: Current 1.1 1.7 4.2 -1.3 -0.8 2.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.5 -0.0 0.2 -0.7 0.1
Whole body water mass 0.1 0.6 1.4 -1.2 0.3 0.3 0.8
Leg predicted mass (right) 0.2 1.1 2.9 -1.7 -0.6 1.0 0.4
Arm fat mass (left) 0.7 3.1 6.1 -2.5 -1.5 2.0 -0.4
Number of self-reported non-cancer illnesses 4.2 7.3 9.9 -2.1 -3.0 3.1 -2.4
Average weekly champagne plus white wine intake 0.3 0.4 0.9 0.3 -0.6 -1.0 0.2
Miserableness 0.5 0.9 1.6 -1.3 -0.6 0.7 -1.0
Guilty feelings 0.4 0.5 1.4 1.2 0.1 -0.9 0.0
Wears glasses or contact lenses 1.0 1.1 2.3 -0.6 -1.5 0.3 -1.3
Ever taken oral contraceptive pill 3.1 3.4 6.8 0.9 2.3 -1.0 2.6
Hearing aid user 0.9 1.0 3.2 0.8 -1.8 -0.3 -0.2
Mother’s age at death 0.2 0.2 0.4 -0.5 0.6 0.2 -0.5
Financial situation satisfaction 1.2 1.5 3.1 1.1 1.1 -1.8 0.4
Tinnitus: Yes, now most or all of the time 4.4 5.2 9.2 -1.0 -2.7 1.7 -3.0
Commuting to job workplace: Public transport 0.3 0.3 0.6 -0.8 -0.3 -0.4 0.7
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 -0.3 -0.1 0.7 -0.4
Medication: Blood pressure 0.9 1.7 3.8 -0.0 -2.0 0.0 -1.8
Pain type(s) experienced in last month: Hip pain 1.9 2.5 4.4 -2.1 -0.1 1.4 -1.8
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.8 -0.7 -0.2 1.7 -0.6
High cholesterol (Self-reported) 1.6 2.8 4.9 -1.1 -2.2 1.8 -1.3
Medication: Bendroflumethiazide 0.3 0.5 0.9 0.9 -0.4 -0.4 0.8
Medication: Paracetamol 1.9 3.0 7.5 -2.7 -0.7 1.7 -1.0
Medication: Lisinopril 0.6 0.8 2.0 -1.4 -1.0 0.6 -0.0
Medication: Atorvastatin 0.4 0.4 1.2 -1.1 0.2 0.7 0.3
Illnesses of father: High blood pressure 0.4 0.5 0.9 -0.9 -0.8 0.0 -0.7
Alcohol drinker status: Never 0.6 0.7 1.5 -0.7 -1.2 0.3 -1.0
Ever smoked 0.1 0.1 0.3 -0.2 -0.3 0.5 -0.2
Basal metabolic rate 0.1 0.8 2.3 -1.5 0.0 0.6 0.7
Leg fat percentage (left) 0.4 1.6 3.2 -1.5 -0.9 1.8 -0.2
Arm fat-free mass (left) 0.1 0.7 1.7 -1.3 0.1 0.7 0.7
Number of operations (self-reported) 1.9 2.8 3.2 -1.6 -1.6 1.6 -1.8
Average weekly beer plus cider intake 0.8 1.2 3.7 0.8 0.2 -0.5 1.9
Irritability 0.2 0.3 0.6 0.8 0.4 -0.6 0.1
Risk taking 0.1 0.1 0.3 0.2 0.3 0.5 -0.2
Ever had prostate specific antigen (PSA) test 0.5 0.6 0.7 -0.8 -0.5 0.8 -0.8
Fractured/broken bones in last 5 years 0.2 0.3 0.5 0.7 0.4 -0.2 0.7
Age started oral contraceptive pill 0.2 0.2 0.3 -0.6 -0.3 0.3 -0.6
Diastolic blood pressure, automated reading 0.3 0.9 1.3 1.1 0.9 -0.9 0.8
Ever depressed for a whole week 0.0 0.0 0.1 -0.0 -0.3 -0.0 0.2
Unable to work because of sickness or disability 3.7 4.8 7.3 -1.7 -2.7 1.3 -2.7
Commuting to job workplace: Cycle 0.2 0.2 0.4 -0.0 -0.6 -0.4 0.6
Myopia 0.4 0.6 1.5 0.0 -0.9 1.2 -0.2
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.7 0.5 0.8 -0.7 0.9
Cholesterol lowering medication 0.3 0.4 0.8 -0.5 -0.9 0.4 -0.7
Medication: Omeprazole (e.g. Zanprol) 2.1 2.6 4.3 -2.1 -1.0 1.5 -1.6
Pain experienced in last month 0.4 0.7 1.4 0.7 0.0 -1.0 1.2
Supplements: Calcium 0.2 0.2 0.7 0.1 0.3 0.4 0.9
Basal cell carcinoma (self-reported) 2.6 3.1 6.2 2.2 1.1 -2.5 0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.3 -0.9 -1.5 0.5 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 -0.2 -0.5 0.2 -0.8
Heart disease (siblings) 0.4 0.5 1.2 0.5 0.4 -0.7 -1.1
Alcohol drinker status: Previous 0.2 0.2 0.3 -0.5 0.5 0.3 0.6
Pack years of smoking 0.5 0.7 1.4 -0.5 -0.9 0.6 -1.2
Impedance of whole body 0.3 1.4 3.3 1.8 0.2 -1.4 0.6
Leg fat mass (left) 0.7 2.7 4.8 -2.2 -1.2 2.1 -0.3
Arm predicted mass (left) 0.1 0.6 1.8 -1.4 0.1 0.6 0.5