Hub : Genes

SNRNP27

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0390	0.0180	1.4e-03	0.026	0.016	0.018	0.014	0.028	3.3e-04	4.6e-03	2.5e-03	6.0e-03	2.1e-04
2	GTEx	Adrenal Gland	0.1281	0.0645	7.5e-03	0.035	NA	0.062	NA	0.106	2.0e-02	NA	3.0e-03	NA	1.3e-04
3	GTEx	Cells EBV-transformed lymphocytes	0.2410	0.1130	8.0e-03	0.024	NA	0.022	NA	0.011	5.5e-02	NA	6.2e-02	NA	1.4e-01
4	GTEx	Muscle Skeletal	0.1921	0.0462	1.7e-11	0.148	NA	0.168	NA	0.156	2.2e-14	NA	2.8e-16	NA	4.4e-15
5	GTEx	Thyroid	0.1180	0.0450	7.6e-04	0.051	NA	0.062	NA	0.053	9.2e-05	NA	1.6e-05	NA	6.7e-05
6	NTR	Blood	0.0693	0.0186	9.0e-15	0.065	0.046	0.055	0.060	0.063	5.4e-20	1.3e-14	3.2e-17	8.6e-19	1.8e-19
7	ROSMAP	Brain Pre-frontal Cortex	0.2386	0.0484	0.0e+00	0.245	0.249	0.272	0.265	0.274	3.8e-31	1.0e-31	5.4e-35	5.1e-34	2.6e-35
8	YFS	Blood	0.0452	0.0138	9.8e-14	0.051	0.051	0.050	0.053	0.051	2.5e-16	2.6e-16	4.6e-16	9.5e-17	3.7e-16
9	TCGA	Breast Invasive Carcinoma	0.0243	0.0173	7.1e-03	0.003	0.010	0.010	NA	0.008	7.5e-02	2.6e-03	2.5e-03	NA	6.3e-03
10	TCGA	Colon Adenocarcinoma	0.0850	0.0510	6.4e-04	0.080	0.058	0.049	NA	0.068	2.1e-05	2.9e-04	7.8e-04	NA	9.0e-05
11	TCGA	Glioblastoma Multiforme	0.1290	0.0900	9.9e-03	0.045	0.030	0.025	NA	0.042	1.6e-02	4.3e-02	6.0e-02	NA	2.0e-02
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.0399	0.0254	9.9e-04	0.024	0.022	0.009	NA	0.021	8.3e-04	1.6e-03	3.0e-02	NA	1.7e-03
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0900	0.0451	3.9e-07	0.021	0.047	0.047	NA	0.040	1.6e-03	4.4e-06	4.7e-06	NA	2.5e-05
14	TCGA	Brain Lower Grade Glioma	0.0486	0.0328	5.3e-05	0.013	0.023	0.020	NA	0.024	1.0e-02	1.1e-03	2.1e-03	NA	9.0e-04
15	TCGA	Lung Adenocarcinoma	0.0641	0.0324	8.2e-06	0.056	0.039	0.042	NA	0.041	3.8e-07	2.0e-05	9.5e-06	NA	1.3e-05
16	TCGA	Lung Squamous Cell Carcinoma	0.0460	0.0294	1.2e-03	0.013	0.028	0.031	NA	0.028	1.1e-02	3.2e-04	1.7e-04	NA	3.5e-04
17	TCGA	Prostate Adenocarcinoma	0.0896	0.0718	1.5e-03	0.015	0.029	0.013	NA	0.027	1.0e-02	5.1e-04	1.6e-02	NA	7.5e-04
18	TCGA	Testicular Germ Cell Tumors	0.1890	0.1190	2.1e-03	0.143	0.098	0.116	NA	0.139	9.9e-06	2.4e-04	6.8e-05	NA	1.3e-05
19	TCGA	Thyroid Carcinoma	0.0650	0.0420	3.7e-04	0.054	0.037	0.047	NA	0.052	5.1e-06	1.4e-04	2.3e-05	NA	8.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Bipolar Disorder (2018)	0.7	1.1	1.8	-1.1	-0.4	0.7	-1.1	1.0	-1.3	-1.2	0.0	0.9	1.2	-1.2	1.1	1.4	-1.2	1.2	1.0	1.0	1.2	1.2
Bipolar Disorder or Schizophrenia	0.9	2.1	3.9	-1.8	-1.0	0.3	-1.5	2.0	-1.8	-1.7	-0.2	1.3	1.7	-1.8	1.5	1.4	-1.5	1.4	0.6	1.2	1.8	1.7
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	-0.9	-1.5	-0.6	-1.2	1.5	-0.8	-1.0	-0.6	-0.2	0.7	-1.1	1.1	0.4	-1.1	0.5	-0.4	-0.2	0.8	0.6
Depression (Nagel 2018)	0.2	0.3	2.6	0.2	-1.2	-1.6	-0.0	0.4	0.4	0.3	-0.4	-0.3	-0.4	0.2	0.1	0.0	0.1	-0.0	-0.2	0.3	-0.4	-0.4
Intelligence (Savage-Jansen 2018)	3.9	12.1	19.1	3.8	-0.5	-2.9	4.3	-4.1	4.1	4.4	-0.3	-2.3	-4.1	4.1	-4.2	-3.2	4.2	-3.5	-1.9	-1.9	-3.9	-3.9
Neuroticism (Nagel 2018)	0.2	0.5	1.1	-0.8	-0.9	-0.6	-1.0	1.1	-0.5	-0.9	-0.6	-0.6	0.5	-0.7	0.7	0.3	-1.1	0.2	-0.6	-0.4	0.4	0.4
Schizophrenia (2018)	0.5	1.1	3.1	-1.4	-0.9	-0.2	-1.0	1.8	-1.3	-1.2	-0.2	0.9	1.2	-1.3	1.0	0.7	-1.0	0.9	-0.0	0.7	1.3	1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.1	-0.9	0.1	0.5	-0.4	0.7	0.3	-0.7	-0.8	-0.7	0.7	-0.6	-1.1	0.4	-1.0	-0.7	-0.7	-0.6	-0.7
Worry (Nagel 2018)	0.2	0.5	1.3	-1.0	-0.4	0.4	-1.0	1.2	-0.8	-0.9	-0.2	0.1	0.7	-0.8	0.8	0.6	-1.0	0.5	-0.1	0.4	0.7	0.6
Alzheimer’s Disease (in mother)	1.9	2.2	5.3	0.2	-2.3	-1.8	0.5	-1.6	1.1	0.6	-2.2	-1.5	-1.2	1.3	-1.4	-2.1	0.5	-1.6	-1.7	-2.0	-1.2	-1.3
Alzheimer’s Disease (in father)	0.2	0.3	0.6	0.1	-0.4	-0.1	-0.6	0.3	-0.7	-0.5	0.1	0.6	0.7	-0.5	0.3	0.5	-0.6	0.8	0.8	-0.1	0.6	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	2.6	0.4	-1.6	-0.7	-0.2	-0.8	0.2	0.1	-1.1	-0.4	-0.2	0.4	-0.4	-0.9	-0.1	-0.4	-0.5	-1.3	-0.3	-0.3
Crohns Disease (2017)	0.4	0.9	3.1	-1.4	-1.1	0.4	-0.3	-0.3	-0.5	-1.3	-1.6	-1.2	0.5	-0.5	0.1	-0.8	-1.2	-0.7	-1.8	-1.3	0.5	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	2.1	-1.4	-0.9	0.5	-0.2	-0.3	-0.8	-1.2	-1.4	-0.6	0.8	-0.7	0.4	-0.7	-1.0	-0.3	-1.2	-1.1	0.8	0.6
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.7	-0.8	0.2	-0.1	-0.2	-0.7	-0.7	-0.8	0.3	0.8	-0.5	0.4	-0.4	-0.5	0.2	-0.4	-0.6	0.7	0.7
Major Depression (MDD)	0.8	1.0	3.8	-0.3	-1.0	-0.3	0.0	-0.2	0.7	-0.0	-1.7	-1.9	-0.7	0.4	-0.5	-1.1	-0.0	-1.3	-1.9	-1.1	-0.7	-0.9
Reaction Time	0.9	1.6	3.7	-1.9	-0.1	0.8	-1.5	1.6	-1.6	-1.9	-0.6	0.9	1.5	-1.6	1.5	0.6	-1.4	0.9	0.0	0.6	1.7	1.4
Verbal and Numeric Reasoning (VNR)	4.9	11.7	22.8	4.1	0.9	-2.9	4.8	-4.0	3.9	4.5	0.4	-1.9	-3.8	4.1	-4.1	-2.9	4.6	-3.2	-1.2	-1.7	-3.9	-3.6
Breast Cancer	1.9	4.7	22.5	-1.6	-2.6	-0.7	0.9	-2.1	0.6	-0.7	-4.7	-2.1	-0.6	1.0	-1.3	-3.2	-1.0	-2.0	-3.6	-3.6	-0.4	-0.9
Ovarian Cancer	0.3	0.5	1.4	-1.0	-0.7	-0.1	-1.0	0.1	-0.3	-0.9	-0.8	-0.8	0.3	-0.5	0.7	-0.3	-1.2	-0.0	-1.1	-0.8	0.4	0.1
Prostate Cancer	0.8	1.2	4.9	-0.4	0.1	2.2	-0.7	0.9	-0.9	-0.6	1.6	1.2	0.9	-0.9	0.7	1.3	-0.4	1.0	1.3	1.3	0.9	1.0
Age at First Birth	0.2	0.2	1.6	0.4	1.2	-0.9	0.7	-0.6	0.4	0.5	0.3	0.4	-0.4	0.4	-0.2	-0.0	0.4	-0.1	-0.0	0.2	-0.2	-0.3
Bipolar Disorder (2011)	0.8	0.8	6.2	-0.1	-2.5	-1.2	0.5	-0.9	0.3	0.2	-1.7	-0.6	-0.4	0.3	-0.7	-0.6	0.0	-0.6	-0.8	-0.8	-0.3	-0.5
Body Mass Index (BMI) (2010)	1.1	1.5	3.2	1.3	-0.2	-1.3	1.7	-0.5	1.6	1.6	0.1	-1.2	-1.6	1.6	-1.3	-0.6	1.4	-1.1	0.1	-0.2	-1.8	-1.4
Coronary Artery Disease (CAD)	0.6	0.7	2.4	-1.6	-0.7	0.8	-1.1	0.9	-1.0	-1.4	-1.0	-0.7	1.2	-0.4	0.7	0.2	-1.0	0.2	0.2	-0.2	0.3	1.1
Crohns Disease (2012)	1.2	1.9	8.2	-1.4	-2.9	-0.0	-0.0	-0.7	0.1	-1.0	-2.6	-2.0	-0.1	0.1	-0.5	-1.5	-1.1	-1.3	-2.3	-1.9	-0.1	-0.3
Mean Putamen Volume	0.1	0.1	1.0	0.5	-0.3	1.0	-0.0	-0.1	0.4	0.4	-0.1	-0.2	-0.5	0.2	-0.2	-0.1	0.4	-0.3	-0.4	0.0	-0.3	-0.5
Fasting Glucose	0.5	0.6	2.8	-0.0	0.5	0.4	-0.3	1.2	-0.5	0.0	0.8	0.8	0.5	-0.4	0.8	0.8	0.3	0.8	1.3	1.7	0.3	0.6
HbA1C	2.3	2.6	4.3	-1.6	1.2	-0.1	-1.2	1.9	-1.9	-1.6	0.8	1.6	1.9	-2.0	1.6	1.7	-1.4	1.7	1.8	1.3	2.1	2.0
HDL Cholesterol	1.1	1.8	3.5	-0.7	0.0	0.5	-1.4	1.4	-1.5	-1.1	0.8	1.6	1.6	-1.4	1.7	1.4	-0.8	1.7	1.9	1.7	1.3	1.6
LDL Cholesterol	1.2	1.8	4.0	0.7	-2.0	-1.1	1.0	-1.0	1.1	0.8	-1.9	-1.7	-1.1	1.1	-1.2	-1.7	0.7	-1.5	-1.5	-1.9	-1.2	-1.2
Lupus	1.6	2.4	3.5	-1.7	-0.2	-0.2	-1.8	1.6	-1.9	-1.7	-0.4	1.5	1.8	-1.9	1.8	1.5	-1.5	1.6	1.4	1.3	1.9	1.8
Neuroticism (2016)	0.7	0.9	3.9	-1.6	-0.8	-0.6	-0.7	0.4	-0.9	-1.4	-2.0	-0.2	1.0	-1.0	0.7	-0.1	-1.4	0.2	-0.4	-0.8	1.0	0.8
Primary Biliary Cirrhosis	1.0	1.4	4.1	-1.5	-0.2	-0.2	-1.8	2.0	-1.2	-1.6	-0.4	0.1	1.2	-1.5	1.8	0.7	-1.7	0.8	0.4	0.2	1.2	1.1
Rheumatoid Arthritis	0.9	1.3	5.9	-0.0	-1.3	-2.4	0.6	-0.8	0.5	0.0	-2.1	-1.4	-0.6	0.4	-0.4	-1.2	-0.2	-1.0	-1.6	-1.6	-0.5	-0.7
Schizophrenia (2014)	1.3	2.9	5.9	-2.4	-1.6	0.5	-2.0	2.3	-2.0	-2.1	-0.5	1.3	2.0	-2.0	1.7	1.1	-1.9	1.4	0.4	1.3	2.0	1.9
Triglycerides	0.2	0.3	0.8	0.2	-0.4	-0.1	0.1	-0.2	0.7	0.4	-0.4	-0.9	-0.7	0.2	-0.5	-0.5	0.2	-0.8	-0.6	-0.6	-0.3	-0.7
Type 2 Diabetes (T2D) (2012)	2.4	2.7	5.6	-1.9	0.5	1.2	-2.4	2.0	-1.8	-2.1	-0.3	0.7	1.9	-1.9	2.0	1.3	-2.2	1.6	1.0	0.8	1.8	1.8
Ulcerative Colitis	0.1	0.1	0.3	-0.4	-0.5	0.6	-0.1	-0.1	-0.5	-0.2	-0.0	0.5	0.5	-0.3	0.3	-0.0	-0.2	0.3	0.2	0.0	0.4	0.5
Blood Eosinophil Count	0.1	0.7	3.3	1.1	0.8	0.0	1.8	-1.6	0.7	0.9	-0.3	-0.3	-0.6	0.8	-1.2	-0.4	0.8	-0.6	-0.1	-0.7	-0.6	-0.6
Blood Platelet Count	4.4	50.6	182.2	5.2	10.3	4.3	-0.8	5.5	-2.8	2.3	13.5	9.9	2.8	-2.9	3.3	9.2	4.2	7.1	12.3	11.4	2.7	4.0
Blood Red Count	0.3	2.4	15.6	1.0	0.9	0.0	-0.2	1.8	-0.7	0.2	4.0	1.9	0.8	-0.6	0.6	2.1	0.8	1.5	2.4	2.4	0.6	1.0
Blood White Count	0.2	1.7	7.1	1.1	1.3	-0.4	2.2	-2.7	1.2	1.2	-0.9	-0.5	-1.1	1.4	-1.4	-1.1	1.1	-0.9	-0.9	-1.1	-1.2	-1.1
Heel T-Score	0.2	1.2	5.4	-0.6	1.1	-0.9	-1.4	2.3	-0.9	-1.3	0.6	0.2	1.0	-1.4	1.4	1.3	-1.0	0.8	0.6	0.9	1.0	0.9
BMI	0.4	2.5	8.1	-2.7	2.9	0.7	-1.5	1.5	-1.4	-2.2	-1.4	-0.2	1.4	-1.8	1.9	0.3	-2.1	0.7	-0.0	0.1	1.5	1.3
Height	0.2	4.7	13.9	3.7	0.7	1.7	2.3	-1.1	1.2	3.1	3.5	2.1	-1.3	1.3	-0.8	1.6	3.2	0.6	3.1	3.0	-1.3	-0.8
Waist Hip Ratio (WHR)	0.2	0.8	4.6	1.1	1.9	-0.4	0.6	0.3	0.3	0.7	2.1	0.5	-0.2	0.2	-0.1	0.9	0.8	0.3	0.9	1.0	-0.3	-0.1
Systolic Blood Pressure	0.5	2.5	11.8	-0.7	3.4	0.0	-0.5	1.8	-1.6	-1.2	1.5	1.9	1.7	-1.3	1.3	1.6	-0.8	1.7	1.6	1.4	1.5	1.8
Smoking Status	0.1	0.3	1.4	0.5	-0.8	-1.2	0.5	-0.7	0.2	0.4	0.3	0.0	-0.2	0.4	-0.6	-0.4	0.4	-0.2	-0.3	-0.8	-0.2	-0.2
Allergy or Eczema	0.1	0.3	3.0	0.8	-1.0	1.7	-0.2	-0.3	0.1	0.5	0.3	0.5	-0.2	0.2	-0.3	0.3	0.5	0.1	0.6	0.4	-0.1	-0.1
Cardiovascular Disease	0.4	1.3	6.0	-1.6	0.0	-0.8	-0.6	0.5	-0.6	-1.6	-2.4	-1.2	0.7	-0.6	0.7	-1.0	-1.6	-0.4	-1.6	-1.7	0.5	0.4
Hypothyroidism (self reported)	1.3	3.1	11.8	0.9	-3.4	-1.3	1.1	-1.2	1.6	1.2	-1.8	-2.2	-1.7	1.5	-1.8	-1.9	0.9	-2.0	-1.8	-2.1	-1.6	-1.7
Respiratory disease	0.1	0.2	0.9	-0.0	-0.4	0.6	-0.9	0.7	-0.4	-0.3	-0.2	0.6	0.3	-0.2	0.3	0.4	-0.4	0.5	0.7	0.1	0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	-0.6	0.7	-0.8	-0.5	0.9	-0.9	-1.0	-0.4	0.1	0.9	-1.0	1.0	0.4	-0.6	0.5	0.1	0.1	0.9	0.9
Lung FEV1/FVC ratio	0.2	0.8	4.8	-0.8	-0.1	-2.2	0.1	-0.3	0.1	-0.5	-1.4	-1.0	-0.0	-0.0	0.0	-1.2	-0.4	-0.7	-1.7	-1.3	-0.0	-0.2
Lung FVC	0.9	4.6	23.9	1.5	-0.1	-0.2	-0.6	1.1	-1.1	0.7	4.9	3.2	1.0	-0.8	0.9	3.1	1.0	2.4	3.7	3.3	0.9	1.4
Neuroticism	0.9	2.1	4.3	-1.8	-1.0	0.3	-1.9	2.1	-1.7	-1.9	-0.3	0.6	1.6	-1.8	1.8	1.4	-1.9	1.2	0.6	0.6	1.6	1.5
Chronotype (morning person)	2.7	6.2	9.8	-2.2	2.1	1.6	-2.4	1.8	-3.0	-2.9	1.2	2.5	3.1	-3.0	2.9	2.5	-2.4	2.8	1.7	1.9	3.1	3.1
Hair Pigment	1.0	27.3	43.0	2.3	-4.9	-5.6	4.4	-6.3	5.0	3.6	-6.6	-5.8	-5.0	5.0	-5.2	-6.3	2.8	-5.9	-5.9	-6.2	-4.9	-5.3
Tanning	0.2	2.1	4.7	-0.1	1.4	2.0	-1.1	0.9	-1.3	-0.6	1.3	1.9	1.3	-1.3	1.5	1.8	-0.3	1.8	1.9	2.2	1.3	1.4
Hand grip strength (left)	0.3	0.8	4.8	-1.1	-1.7	0.8	0.3	-0.5	0.1	-0.6	-2.2	-0.6	-0.1	0.3	-0.2	-1.0	-0.8	-0.6	-1.0	-0.9	-0.1	-0.2
Number of treatments/medications taken	0.2	0.3	1.0	1.0	0.1	-0.4	0.8	-0.8	0.5	0.9	0.3	-0.2	-0.5	0.5	-0.5	-0.2	1.0	-0.3	-0.1	-0.2	-0.6	-0.5
Average weekly spirits intake	1.2	1.5	3.6	1.0	-0.4	-1.9	1.4	-1.3	1.3	1.3	-1.0	-1.2	-1.2	1.2	-1.2	-1.2	1.3	-1.4	-1.0	-1.1	-1.2	-1.3
Sensitivity / hurt feelings	0.5	0.9	4.8	-1.5	-0.1	-0.4	-0.4	-0.3	-0.1	-1.0	-2.2	-1.0	0.1	-0.2	-0.0	-0.7	-1.5	-0.5	-1.5	-1.4	0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.9	-0.1	-0.9	-1.4	0.1	0.3	0.5	0.2	-0.6	-0.6	-0.6	0.4	-0.2	-0.4	0.1	-0.5	-0.7	-0.2	-0.5	-0.6
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.0	-0.9	-0.6	-1.0	1.3	-1.1	-1.0	0.1	0.6	1.0	-1.1	1.0	0.6	-0.8	0.8	0.4	0.5	1.0	1.0
Relative age of first facial hair	1.3	2.6	4.5	-0.8	0.7	1.6	-1.5	1.9	-1.6	-1.4	1.8	1.8	1.7	-1.4	1.6	2.1	-1.2	2.0	1.6	2.1	1.4	1.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	3.0	-0.0	-1.0	-0.4	0.9	-1.7	1.0	0.6	-1.3	-1.3	-1.0	1.0	-0.9	-1.6	0.4	-1.3	-1.7	-1.4	-1.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	0.0	-0.7	-1.0	0.4	-1.0	0.6	0.5	-0.4	-0.8	-0.6	0.7	-0.7	-0.8	0.3	-0.7	-0.7	-0.7	-0.7	-0.6
Ever had hysterectomy (womb removed)	6.0	6.7	12.0	-1.2	1.9	2.1	-2.3	2.6	-2.6	-1.8	2.6	3.0	2.6	-2.8	2.7	3.2	-1.5	3.0	3.5	3.1	2.7	2.8
Systolic blood pressure, automated reading	0.4	1.1	3.9	-1.6	2.0	-0.1	-0.4	0.9	-1.2	-1.6	-0.4	0.7	1.3	-1.0	1.0	0.1	-1.4	0.7	-0.2	-0.1	1.3	1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	-0.2	-1.0	0.8	-0.1	0.1	-0.2	-0.5	-0.8	-0.5	0.2	-0.2	-0.1	-0.2	-0.4	-0.3	-0.4	-0.6	0.2	0.1
Angina	7.4	9.7	15.9	-2.5	2.2	4.0	-3.2	2.8	-3.6	-3.1	1.7	3.0	3.6	-3.4	3.4	3.1	-2.6	3.4	3.0	2.6	3.4	3.7
Medication for hormone replacement therapy	0.6	0.7	2.0	-1.3	-0.4	0.1	-1.4	0.9	-0.9	-1.0	0.1	0.6	0.8	-0.8	0.9	0.5	-1.0	0.8	0.5	0.5	0.8	0.8
Vitamin and mineral supplements	0.3	0.5	4.2	-0.2	2.1	0.6	-0.4	0.8	-0.2	-0.3	0.9	0.4	0.2	-0.3	0.5	0.5	-0.5	0.5	0.4	0.7	0.2	0.2
Supplements: Zinc	0.3	0.3	0.9	-0.9	0.5	0.9	-0.3	0.9	-0.4	-0.5	0.5	0.5	0.5	-0.4	0.5	0.5	-0.4	0.4	0.0	0.8	0.4	0.4
Medication: Co-codamol	3.2	3.7	5.6	-1.0	2.2	1.7	-1.7	1.9	-1.9	-1.4	1.9	2.2	1.9	-2.1	2.1	2.4	-1.2	2.2	2.0	2.3	1.9	1.9
Medication: Metformin	0.2	0.3	0.8	-0.8	-0.1	-0.1	-0.3	-0.3	-0.5	-0.9	-0.7	-0.3	0.5	-0.5	0.3	-0.3	-0.9	0.0	-0.7	-0.9	0.5	0.4
Diabetes (father)	0.7	0.9	1.5	-0.3	0.8	0.6	-0.9	1.0	-1.0	-0.7	0.9	1.1	1.0	-1.1	1.2	1.0	-0.4	1.0	1.0	1.2	1.1	1.0
Diabetes (mother)	1.0	1.3	4.4	-2.0	-1.4	0.7	-0.7	0.1	-0.2	-1.2	-2.1	-1.3	0.2	-0.1	0.0	-1.1	-1.5	-0.7	-1.9	-1.5	0.1	-0.1
Severe depression (siblings)	1.4	1.6	3.3	0.7	-1.4	-0.6	0.6	-1.6	1.1	0.8	-1.8	-1.7	-1.1	1.1	-1.3	-1.4	0.7	-1.5	-1.5	-1.5	-1.2	-1.2
Pack years adult smoking proportion	0.3	0.4	1.8	-1.4	0.6	-0.7	-0.8	0.5	-0.5	-0.9	-0.5	-0.1	0.5	-0.6	0.6	-0.1	-0.9	0.2	-0.5	-0.1	0.5	0.4
Impedance of leg (right)	0.4	1.7	5.2	2.3	-1.1	-1.6	1.4	-1.0	1.5	1.8	0.2	-0.4	-1.4	1.7	-1.6	-0.6	1.6	-0.9	-0.2	-0.2	-1.6	-1.4
Leg fat-free mass (left)	0.1	0.4	2.9	-0.6	1.7	1.1	-0.1	0.3	-0.1	-0.1	-0.0	0.3	0.1	-0.4	0.7	0.4	-0.1	0.2	0.6	0.8	0.2	0.2
Trunk fat percentage	0.3	1.3	5.4	-2.0	1.9	-1.5	-0.3	0.4	-0.5	-1.4	-2.3	-0.7	0.6	-0.8	1.0	-0.6	-1.6	-0.0	-1.0	-0.7	0.7	0.4
Hand grip strength (right)	0.7	1.8	7.6	-0.6	-1.4	-0.5	0.9	-1.1	0.9	0.1	-2.8	-1.6	-0.9	1.2	-0.9	-2.0	-0.2	-1.5	-1.8	-1.8	-1.0	-1.0
Townsend deprivation index at recruitment	0.1	0.1	1.0	0.4	1.0	0.0	-0.2	-0.2	0.1	0.2	0.2	-0.4	-0.1	-0.0	0.1	0.1	0.2	-0.1	0.1	0.0	-0.2	-0.1
Current tobacco smoking	0.4	0.6	3.4	-0.3	-1.0	-1.8	0.4	-0.6	0.6	0.2	-0.6	-0.7	-0.6	0.5	-0.6	-1.0	0.0	-0.9	-1.4	-1.0	-0.4	-0.7
Average weekly fortified wine intake	0.2	0.2	1.3	0.2	0.5	1.0	0.1	0.5	0.1	0.2	1.1	0.1	-0.1	0.1	0.1	0.4	0.4	0.1	0.5	0.8	-0.2	-0.0
Maternal smoking around birth	0.3	0.4	1.5	1.0	-0.2	-0.7	0.4	-0.1	0.3	0.9	1.0	0.9	-0.4	0.1	-0.1	0.3	1.2	0.1	0.9	0.8	-0.1	-0.2
Fed-up feelings	0.7	1.2	4.5	-1.4	-2.1	-0.1	-1.6	1.0	-0.6	-1.2	-1.5	-1.0	0.5	-1.0	1.0	-0.2	-1.5	-0.0	-1.3	-1.0	0.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.2	-0.4	0.4	-0.6	-1.0	1.4	-0.8	-0.6	0.8	1.1	0.7	-1.1	1.3	1.2	-0.5	1.1	1.0	1.5	1.0	0.8
Relative age voice broke	0.0	0.1	0.3	0.4	0.5	0.2	-0.1	0.1	0.1	-0.1	0.1	-0.4	-0.0	0.1	-0.1	0.4	-0.0	-0.1	-0.1	0.0	-0.2	-0.1
Taking other prescription medications	0.3	0.5	2.4	1.5	-0.1	0.2	0.9	-0.5	0.5	1.2	0.7	0.0	-0.6	0.7	-0.6	-0.0	1.4	-0.2	0.3	0.2	-0.8	-0.5
Age when periods started (menarche)	0.6	1.4	2.4	0.9	-0.2	-1.1	0.9	-0.9	1.5	1.2	0.0	-1.4	-1.5	1.3	-1.0	-1.2	1.0	-1.4	-1.2	-0.8	-1.5	-1.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	2.7	-1.2	-0.4	0.3	-1.6	1.5	-1.3	-1.1	0.5	1.1	1.2	-1.1	1.1	1.3	-1.3	1.2	1.2	1.1	1.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	6.0	-1.7	0.4	0.1	-1.7	2.4	-1.4	-1.7	-0.2	0.4	1.4	-1.6	1.7	1.1	-1.5	1.0	0.7	1.1	1.3	1.4
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	10.4	-3.2	-2.4	1.9	-2.0	0.3	-1.4	-2.7	-2.9	-0.8	1.4	-1.3	0.8	-0.7	-2.9	0.0	-2.0	-1.7	1.4	1.0
Qualifications: CSEs or equivalent	0.6	0.7	1.2	-0.7	-0.4	0.9	-1.1	1.0	-1.0	-0.8	0.0	0.9	0.9	-0.9	0.9	0.8	-0.8	0.9	1.0	0.8	1.0	1.0
Serious illness, injury or assault to yourself	0.4	0.5	1.5	-0.3	1.2	1.2	-0.9	0.9	-0.5	-0.7	0.3	0.2	0.5	-0.5	0.8	0.7	-0.9	0.6	0.5	0.2	0.4	0.5
High blood pressure	0.3	0.9	4.4	-1.5	0.4	-0.3	-0.2	-0.1	-0.6	-1.3	-2.1	-0.6	0.7	-0.6	0.5	-0.9	-1.2	-0.2	-1.6	-1.4	0.7	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	6.1	0.4	-1.1	2.5	-0.4	-0.3	0.1	0.3	0.1	0.3	-0.2	0.2	-0.2	0.2	0.1	0.0	0.3	0.1	-0.1	-0.1
Multivitamins +/- minerals	0.3	0.4	1.0	0.8	-1.0	-0.5	0.5	-0.7	0.7	0.8	0.0	-0.6	-0.7	0.7	-0.7	-0.4	0.8	-0.6	-0.5	-0.4	-0.7	-0.7
Stomach or abdominal pain in last month	2.8	3.4	4.7	-1.6	0.1	0.6	-2.0	2.1	-2.1	-1.9	1.5	2.1	2.1	-2.0	2.0	2.1	-1.7	2.2	1.6	2.0	2.0	2.1
Supplements: Glucosamine	0.5	0.6	1.4	-0.6	0.1	0.0	-0.6	0.3	-1.1	-1.0	0.2	0.6	1.2	-0.9	0.9	0.9	-1.0	1.1	0.4	0.1	0.9	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	-1.4	-0.9	0.1	-1.5	0.2	-0.8	-1.3	-0.8	-0.4	0.8	-0.7	0.6	0.1	-1.4	0.3	-0.1	-0.4	0.7	0.7
Medication: Atenolol	0.3	0.4	1.3	0.8	0.9	-0.8	1.1	-0.8	0.3	0.8	-0.3	0.0	-0.3	0.5	-0.5	-0.6	0.9	-0.3	-0.1	-0.4	-0.4	-0.3
Medication: Levothyroxine sodium	2.4	4.0	8.9	1.7	-3.0	-2.0	1.8	-1.7	2.0	1.9	-1.2	-1.9	-2.1	2.1	-2.2	-2.0	1.9	-2.2	-1.8	-1.9	-2.1	-2.1
Sitting height	0.5	3.3	8.6	2.9	2.5	0.8	2.0	-1.0	1.4	2.6	2.7	1.2	-1.4	1.4	-1.0	0.8	2.7	-0.0	2.1	1.9	-1.4	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	2.0	1.4	-0.7	-0.7	0.4	0.2	0.9	1.0	0.4	-0.6	-1.0	0.4	-0.6	0.1	1.0	-0.6	0.2	0.1	-0.8	-0.9
High blood pressure (mother)	2.2	3.1	6.3	-2.4	0.6	2.2	-2.1	1.6	-2.1	-2.5	-0.6	0.8	2.1	-2.0	1.7	1.2	-2.5	1.6	0.2	0.4	2.0	1.9
Body mass index (BMI)	0.8	3.5	11.4	-3.4	1.4	0.3	-2.2	2.0	-1.9	-2.8	-1.9	0.1	1.9	-2.2	2.3	0.4	-2.7	1.0	-0.4	0.1	2.1	1.7
Impedance of leg (left)	0.2	1.1	4.2	2.0	-0.8	-1.5	1.2	-0.7	1.1	1.4	0.1	-0.4	-1.1	1.2	-1.2	-0.4	1.4	-0.7	-0.0	-0.1	-1.2	-1.0
Leg predicted mass (left)	0.1	0.3	2.9	-0.6	1.7	1.1	-0.0	0.3	-0.1	-0.1	-0.0	0.3	0.1	-0.4	0.6	0.3	-0.0	0.2	0.6	0.8	0.2	0.1
Trunk fat mass	0.2	0.9	4.5	-1.6	2.1	-0.9	-0.1	0.3	-0.4	-1.0	-1.8	-0.4	0.5	-0.7	0.9	-0.4	-1.2	0.0	-0.6	-0.2	0.6	0.3
Waist circumference	0.1	0.3	2.7	-1.0	1.6	-0.2	-0.1	0.4	-0.2	-0.6	-0.7	-0.3	0.2	-0.5	0.6	-0.0	-0.6	-0.0	-0.3	0.2	0.3	0.2
Number of incorrect matches in round	0.7	1.2	4.2	0.3	1.1	0.6	-0.6	0.9	-0.7	-0.2	2.1	1.6	0.8	-0.7	0.7	1.6	0.1	1.3	1.8	1.8	0.6	0.9
Past tobacco smoking	0.2	0.4	3.2	0.7	1.8	-0.3	0.3	0.5	0.8	0.5	0.1	-0.6	-0.8	0.5	-0.2	-0.1	0.4	-0.5	-0.1	0.4	-0.7	-0.8
Alcohol usually taken with meals	1.4	2.3	5.6	1.3	-0.8	1.7	1.6	-2.4	1.5	1.1	-0.9	-1.8	-1.4	1.5	-1.7	-1.3	1.1	-1.6	-1.5	-1.8	-1.6	-1.5
Nervous feelings	0.0	0.1	0.4	-0.2	0.5	0.1	-0.1	0.5	0.1	-0.2	-0.2	-0.7	-0.1	0.2	-0.1	-0.2	-0.1	-0.4	-0.2	-0.3	-0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	3.2	-0.7	-0.0	-0.7	-0.8	1.8	-0.6	-0.4	0.7	0.8	0.5	-0.7	0.9	0.9	-0.2	0.8	1.2	1.4	0.6	0.6
Hearing difficulty/problems with background noise	2.1	3.3	5.6	-2.3	-0.6	-0.0	-2.3	2.4	-2.3	-2.4	0.2	1.3	2.2	-2.2	2.0	1.3	-2.0	1.6	0.7	1.1	2.2	2.1
Hair/balding pattern: Pattern 2	1.6	2.0	5.8	-1.7	1.2	2.4	-1.4	0.8	-1.6	-2.0	-0.2	0.7	1.7	-1.5	1.5	0.6	-1.9	1.2	0.7	0.1	1.6	1.6
Had menopause	0.8	1.0	3.8	0.4	-0.5	-2.0	0.8	-1.8	0.7	0.7	-1.1	-0.8	-0.7	0.9	-1.0	-1.1	0.5	-0.8	-1.0	-1.2	-0.8	-0.7
Had other major operations	1.1	1.3	2.8	0.0	-0.1	1.3	-1.3	1.0	-1.1	-0.7	1.5	1.1	1.1	-1.2	1.2	1.7	-0.8	1.4	1.4	1.0	1.0	1.1
Forced vital capacity (FVC)	0.6	2.5	11.6	1.9	0.1	0.7	0.7	0.3	0.3	1.8	3.4	2.1	-0.3	0.5	-0.3	1.7	2.0	1.0	2.8	2.7	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.6	-1.6	-0.5	-0.5	-0.7	1.3	-0.7	-1.2	-0.9	-0.3	0.8	-0.8	0.6	-0.1	-1.0	0.0	-0.3	-0.0	0.7	0.7
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	10.7	-2.8	-3.3	0.7	-1.4	-0.5	-1.1	-2.1	-3.2	-0.7	1.1	-0.8	0.6	-1.0	-2.2	-0.2	-1.6	-1.4	1.1	0.8
Qualifications: None of the above	1.3	2.8	6.0	-2.3	0.7	-1.5	-1.8	2.4	-1.9	-2.0	-0.5	0.8	1.9	-2.1	2.2	1.4	-1.8	1.4	0.7	1.2	1.9	1.8
Financial difficulties in last 2 years	0.9	1.2	3.1	-1.6	0.5	0.3	-1.8	1.2	-1.0	-1.6	-1.2	-0.3	1.0	-1.4	1.4	0.2	-1.7	0.4	-0.5	-0.3	1.2	0.9
Mouth/teeth dental problems	2.4	3.7	6.2	1.3	-2.1	-0.9	1.7	-1.8	2.2	1.9	-0.9	-1.8	-2.3	2.5	-2.4	-2.0	1.5	-2.2	-1.8	-1.8	-2.3	-2.3
Heart attack	1.8	2.2	4.0	-1.3	1.5	-0.3	-2.0	1.8	-1.6	-1.7	0.9	1.2	1.7	-1.8	1.7	1.6	-1.6	1.6	0.9	0.9	1.7	1.6
Allergy	0.7	1.6	7.2	-0.0	-0.0	-2.7	1.3	-0.9	1.1	0.6	-1.2	-1.5	-1.0	1.0	-1.0	-1.6	0.7	-1.5	-1.6	-1.2	-1.0	-1.1
Pain all over the body in last month	0.2	0.2	0.8	-0.4	-0.5	0.9	-0.2	0.6	-0.2	-0.0	0.1	0.6	0.1	-0.3	0.4	0.2	0.1	0.2	0.8	0.9	0.4	0.2
Diabetes (self-reported)	0.6	1.0	3.8	-1.0	-1.0	-1.5	-0.2	-0.2	-0.4	-1.1	-1.9	-1.1	0.4	-0.5	0.3	-1.0	-0.9	-0.5	-1.3	-1.6	0.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	-0.3	-0.8	-0.1	-0.1	-0.4	0.4	0.2	-1.1	-0.4	-0.4	0.6	-0.3	-0.8	-0.1	-0.5	-0.6	-0.2	-0.4	-0.5
Medication: Ramipril	0.2	0.3	1.8	0.2	1.3	-1.2	0.2	0.2	0.3	0.3	1.4	-0.2	-0.3	0.2	-0.1	0.3	0.2	0.1	-0.0	0.3	-0.4	-0.2
Medication: Simvastatin	0.3	0.5	3.7	0.4	0.5	-1.9	0.9	-0.5	0.3	0.2	-0.3	-0.6	-0.3	0.3	-0.3	-0.7	0.4	-0.5	-1.0	-0.9	-0.3	-0.4
Fluid intelligence score	2.0	4.1	9.1	2.3	1.4	-1.8	3.0	-2.3	2.2	2.6	0.1	-1.2	-2.1	2.3	-2.3	-1.8	2.8	-1.9	-0.6	-0.9	-2.3	-2.0
Illnesses of siblings	0.7	1.0	3.0	1.6	-0.8	-1.4	1.2	-0.7	0.9	1.5	0.6	-0.0	-0.9	1.0	-1.0	-0.2	1.7	-0.6	0.5	0.3	-1.0	-0.8
Neuroticism score	1.2	2.5	5.0	-2.2	-0.8	0.9	-2.2	2.1	-1.8	-2.1	-0.9	0.5	1.7	-1.9	1.8	1.1	-2.1	1.2	0.4	0.5	1.8	1.6
Weight	0.1	0.3	3.1	-0.8	1.8	0.3	0.0	0.5	-0.1	-0.3	-0.7	0.1	0.1	-0.4	0.7	0.0	-0.2	0.1	0.2	0.6	0.3	0.1
Impedance of arm (right)	0.8	3.7	9.5	2.1	0.3	-3.1	2.5	-2.1	2.1	2.0	-0.5	-1.4	-2.0	2.2	-2.2	-1.6	1.6	-1.7	-1.4	-1.3	-2.1	-2.0
Arm fat percentage (right)	0.7	2.7	10.2	-3.2	1.4	-1.4	-1.2	1.0	-1.3	-2.4	-2.8	-0.7	1.3	-1.5	1.5	-0.6	-2.6	0.3	-1.5	-0.9	1.4	1.0
Trunk fat-free mass	0.1	0.7	3.5	0.5	0.8	1.9	0.3	0.3	0.2	0.7	1.0	0.8	-0.2	0.0	0.2	0.8	0.9	0.3	1.3	1.5	-0.1	-0.1
Hip circumference	0.1	0.6	2.8	-1.7	0.5	0.3	-0.5	0.6	-0.5	-1.1	-1.5	-0.5	0.5	-0.8	0.9	-0.2	-1.1	-0.0	-0.5	0.1	0.6	0.3
Time employed in main current job	0.1	0.1	0.3	0.1	0.3	0.0	0.3	-0.5	-0.1	0.1	-0.4	0.5	0.1	0.0	-0.2	0.1	0.1	0.1	0.6	0.0	0.2	0.1
Alcohol intake versus 10 years previously	0.6	0.9	1.9	-1.0	-0.5	0.0	-1.4	1.4	-1.1	-1.1	-0.6	0.6	1.1	-1.1	1.1	0.7	-1.0	1.0	0.5	0.5	1.0	1.0
Father’s age at death	1.0	1.4	3.4	0.8	-0.5	-0.5	0.8	-1.5	1.3	0.8	-1.1	-1.7	-1.3	1.1	-1.2	-1.1	0.3	-1.2	-1.8	-1.4	-1.3	-1.4
Worrier / anxious feelings	1.2	2.3	4.2	-2.1	-0.6	1.1	-1.7	1.5	-1.9	-2.0	-0.2	0.9	1.9	-1.9	1.7	1.1	-1.9	1.3	0.3	0.5	1.9	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.5	-0.8	-0.9	0.7	-0.9	1.6	-0.8	-0.9	0.1	0.1	0.7	-1.0	0.9	0.7	-0.8	0.6	0.4	0.5	0.7	0.7
Falls in the last year	0.8	1.0	1.7	-1.2	1.2	0.3	-0.9	0.9	-1.1	-1.2	0.1	1.1	1.1	-1.1	1.3	0.8	-1.2	1.1	0.5	1.1	1.1	1.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.9	-0.6	-1.4	-1.1	-0.3	0.5	-0.3	-0.6	-1.0	-0.4	0.3	-0.2	0.1	-0.2	-0.7	-0.1	-1.0	-0.8	0.2	0.1
Number of live births	2.6	3.7	5.9	-1.1	0.9	0.3	-1.5	2.1	-2.2	-1.7	1.2	2.2	2.2	-2.4	2.4	2.3	-1.4	2.3	2.1	2.1	2.3	2.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	8.5	0.8	0.2	0.3	-0.2	1.1	-0.6	0.6	2.8	2.4	0.6	-0.5	0.7	2.0	1.0	1.5	2.8	2.9	0.5	0.9
Pulse rate	0.2	0.4	1.3	-0.3	-0.3	0.7	-0.1	0.9	-0.4	-0.1	0.6	1.1	0.3	-0.4	0.6	0.6	-0.1	0.7	0.8	1.2	0.5	0.4
Happiness	0.7	0.8	2.9	-1.5	-1.6	-1.7	-0.6	0.5	-0.7	-1.0	-1.5	-0.2	0.7	-0.5	0.4	-0.3	-1.1	0.1	-0.6	-0.6	0.6	0.6
Noisy workplace	0.4	0.5	1.8	-1.3	-0.2	0.1	-0.9	0.9	-0.8	-1.2	-0.3	-0.1	0.8	-0.9	0.6	0.3	-1.1	0.3	-0.4	-0.0	0.8	0.7
Qualifications: A levels/AS levels or equivalent	5.3	11.8	20.9	4.0	-0.2	-2.2	4.6	-4.3	3.8	3.8	-0.3	-3.0	-3.7	4.0	-4.0	-3.3	3.5	-3.5	-2.5	-3.3	-3.8	-3.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.4	0.9	-1.0	-0.7	1.1	-1.5	0.7	0.7	-0.4	-0.9	-0.7	0.7	-1.1	-0.8	0.8	-0.9	-0.6	-1.3	-0.7	-0.7
Mouth/teeth dental problems: Dentures	2.0	3.4	13.1	-0.6	3.6	0.2	-0.4	1.3	-1.8	-1.1	1.9	2.5	1.9	-1.8	2.0	2.0	-0.7	2.2	1.9	2.2	1.9	1.9
Asthma	0.1	0.2	1.0	-0.0	0.0	1.0	-0.8	0.4	-0.2	-0.3	-0.6	0.1	0.2	-0.1	0.2	0.2	-0.5	0.3	0.2	-0.2	0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.3	-1.0	-0.3	1.8	-1.7	0.7	-1.3	-0.9	0.6	1.5	1.2	-1.1	1.1	1.1	-0.7	1.2	1.2	1.4	1.2	1.3
Medication: Cholesterol lowering	0.8	1.3	3.5	0.8	0.9	-1.9	1.5	-0.9	1.0	0.9	-0.8	-1.3	-1.0	1.1	-1.1	-1.2	0.9	-1.2	-1.3	-1.3	-1.1	-1.1
Depression (self-reported)	0.1	0.2	0.5	-0.2	-0.7	-0.6	-0.5	0.5	-0.1	-0.4	-0.7	-0.3	0.0	-0.1	0.1	-0.3	-0.5	-0.1	-0.4	-0.5	0.1	-0.0
Medication: Lansoprazole	3.3	3.8	7.1	-2.2	-0.0	-0.0	-2.5	2.2	-2.4	-2.7	-0.1	1.5	2.4	-2.2	2.2	1.5	-2.5	2.0	1.0	0.8	2.3	2.3
Prospective memory result	0.8	1.0	2.1	-0.6	0.8	0.1	-0.6	1.3	-1.0	-0.8	1.1	1.1	1.0	-1.2	1.5	1.1	-0.8	1.2	0.6	1.3	1.1	1.0
Lung cancer (father)	1.0	1.1	4.5	1.7	0.0	-2.1	1.5	-0.6	0.8	1.6	1.2	-0.2	-0.9	0.7	-0.7	0.1	1.8	-0.4	0.5	0.4	-0.9	-0.7
Illnesses of mother	0.6	0.7	2.4	0.8	1.2	-1.0	0.7	0.2	0.1	0.7	1.4	1.0	-0.0	0.2	-0.1	0.7	0.8	0.5	1.6	1.3	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	5.8	1.0	0.1	0.7	0.2	0.5	0.1	1.1	2.4	1.6	-0.2	0.2	0.1	1.2	1.3	0.6	1.9	2.2	-0.2	0.1
Pulse wave Arterial Stiffness index	0.8	0.9	2.0	1.4	0.5	-0.7	1.4	-1.2	1.0	1.3	0.8	-0.1	-1.1	1.1	-1.0	-0.3	1.3	-0.6	-0.0	-0.1	-1.0	-1.0
Impedance of arm (left)	1.0	4.7	11.4	2.4	-0.1	-3.4	2.9	-2.5	2.4	2.4	-0.5	-1.5	-2.3	2.6	-2.5	-1.8	1.9	-1.9	-1.3	-1.5	-2.4	-2.2
Arm fat mass (right)	0.5	2.1	7.5	-2.7	1.6	-0.1	-1.3	1.3	-1.3	-2.0	-1.8	0.1	1.4	-1.6	1.7	0.1	-2.1	0.6	-0.4	0.1	1.5	1.2
Trunk predicted mass	0.1	0.7	3.5	0.5	0.7	1.9	0.2	0.4	0.1	0.7	1.1	0.9	-0.2	-0.0	0.2	0.8	0.9	0.4	1.3	1.6	-0.1	-0.0
Standing height	0.9	9.3	25.5	5.0	1.2	0.3	4.3	-2.8	3.4	4.8	2.4	0.1	-3.5	3.4	-2.9	-0.5	4.9	-1.7	1.4	1.3	-3.4	-3.0
Length of working week for main job	1.6	1.7	3.9	1.6	1.2	-1.8	1.4	-1.2	1.5	1.8	0.2	-0.4	-1.5	1.4	-1.1	-1.1	2.0	-1.1	-0.4	-0.3	-1.4	-1.4
Exposure to tobacco smoke at home	0.4	0.4	3.0	0.9	0.8	-0.4	0.2	-0.0	0.4	0.7	1.7	0.4	-0.4	0.2	-0.0	0.2	1.1	-0.0	0.6	0.9	-0.4	-0.3
Breastfed as a baby	1.5	1.8	3.9	2.0	1.6	-0.8	1.5	-1.2	1.7	1.9	1.0	-0.6	-1.6	1.5	-1.4	-0.4	1.7	-1.0	-0.1	-0.1	-1.6	-1.5
Tense / ‘highly strung’	2.0	3.3	5.7	-2.2	-0.4	-0.2	-2.2	2.4	-2.2	-2.3	-0.2	1.1	2.1	-2.3	2.1	1.7	-2.1	1.6	1.0	1.2	2.2	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.1	-1.9	-1.3	-0.4	-1.9	1.0	-1.4	-2.0	-1.3	-0.1	1.3	-1.4	1.1	0.5	-2.3	0.7	-0.5	-0.7	1.4	1.1
Hair/balding pattern: Pattern 4	1.9	4.5	9.0	1.5	-1.4	-3.0	1.9	-2.8	2.3	1.8	-2.0	-2.4	-2.3	2.0	-1.9	-2.1	1.2	-2.2	-2.3	-1.9	-2.2	-2.4
Birth weight of first child	1.0	1.8	3.7	-1.9	-0.0	0.3	-0.9	1.1	-1.7	-1.6	0.0	1.2	1.8	-1.7	1.6	1.0	-1.5	1.4	1.1	1.0	1.8	1.8
Peak expiratory flow (PEF)	0.7	1.6	5.6	-0.5	0.6	0.1	-1.0	1.1	-1.0	-0.2	1.7	2.0	0.9	-0.7	1.0	1.5	-0.0	1.4	2.1	2.4	0.9	1.1
Pulse wave reflection index	2.6	3.2	5.5	1.9	-0.4	-2.3	1.7	-1.9	2.0	1.8	-0.3	-1.9	-2.0	2.0	-2.0	-1.5	1.6	-1.9	-1.5	-1.5	-2.1	-2.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	-1.3	-1.0	0.9	-1.5	0.6	-1.1	-1.1	-0.9	0.8	1.0	-0.9	0.8	0.2	-0.8	0.7	0.2	0.4	1.0	0.9
Loud music exposure frequency	2.2	2.4	5.4	-2.3	-1.3	1.9	-1.8	2.2	-1.6	-1.9	-1.1	0.7	1.5	-1.7	1.3	1.0	-1.8	1.0	0.7	0.9	1.7	1.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	2.8	0.7	-0.5	1.0	1.7	-1.6	1.3	1.0	-0.6	-1.3	-1.3	1.5	-1.5	-1.6	0.7	-1.4	-1.6	-1.6	-1.3	-1.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.5	-1.9	-1.0	-0.9	-1.5	0.9	-1.2	-1.8	-1.9	-0.3	1.2	-1.4	1.2	-0.3	-1.8	0.4	-0.4	-0.8	1.2	1.0
Blood clot in the leg (DVT)	3.2	4.2	7.7	-0.2	2.6	1.8	-1.3	1.4	-1.9	-1.1	2.5	2.8	2.0	-1.8	1.9	2.7	-0.7	2.6	2.7	2.6	1.8	2.1
Medication: Paracetamol	0.8	1.4	2.1	-1.0	1.0	1.2	-1.3	1.0	-1.2	-1.1	1.1	1.2	1.2	-1.2	1.3	1.5	-1.0	1.2	1.2	1.2	1.2	1.3
Headache pain in last month	1.3	2.3	9.2	-0.1	-3.0	-1.6	0.1	-1.0	1.1	0.4	-2.1	-2.0	-1.2	1.1	-1.3	-1.9	0.3	-1.7	-2.0	-1.9	-1.2	-1.3
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	7.2	-0.6	-1.1	2.7	-1.8	1.1	-1.6	-1.0	2.0	2.5	1.5	-1.5	1.5	2.0	-0.8	2.0	2.3	2.3	1.7	1.6
Glaucoma (self-reported)	0.2	0.2	0.6	0.6	0.8	0.1	-0.5	-0.2	-0.2	0.1	0.6	0.3	0.2	-0.6	0.4	0.7	-0.0	0.5	0.6	0.3	0.3	0.2
Gout (self-reported)	0.7	1.0	2.3	0.6	-1.1	1.5	0.6	-0.4	1.0	0.6	-0.6	-1.4	-1.0	1.0	-1.1	-0.8	0.4	-1.1	-1.4	-1.0	-1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	2.0	4.0	14.4	1.2	-3.8	-2.0	1.3	-1.3	1.7	1.4	-2.0	-2.4	-1.8	1.7	-2.0	-2.1	1.4	-2.2	-2.0	-2.3	-1.8	-1.9
Medication: Amlodipine	0.5	0.6	5.2	0.3	2.3	-2.2	0.7	0.7	0.0	0.2	0.2	0.2	0.0	-0.1	0.2	0.2	0.4	0.1	0.2	0.4	-0.0	0.1
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.9	0.9	0.2	1.3	0.4	-1.1	1.3	1.0	-0.6	-1.1	-1.4	1.3	-1.3	-0.9	0.8	-1.1	-0.9	-0.6	-1.3	-1.4
Birth weight	1.4	3.0	7.3	-0.2	0.6	0.7	-1.0	1.5	-1.8	-0.7	2.2	2.2	1.7	-1.9	2.0	2.2	-0.3	2.1	2.7	2.3	1.7	1.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.3	1.1	0.2	0.6	0.3	-0.9	0.4	0.7	1.0	-0.1	-0.5	0.4	-0.2	0.2	0.5	-0.1	0.1	-0.2	-0.5	-0.4
High blood pressure (siblings)	1.0	1.5	4.8	-1.9	0.6	1.1	-1.3	0.7	-1.3	-2.0	-0.5	0.1	1.4	-1.2	1.3	0.3	-2.2	0.9	-0.6	-0.5	1.3	1.2
Forced vital capacity (FVC), Best measure	0.6	2.1	9.0	1.9	0.3	1.1	0.8	0.1	0.6	1.8	3.0	1.6	-0.6	0.8	-0.5	1.2	2.0	0.5	2.3	2.3	-0.7	-0.3
Body fat percentage	0.5	1.9	6.6	-2.5	1.6	-1.4	-0.8	0.7	-0.9	-1.9	-2.6	-0.7	1.0	-1.1	1.2	-0.5	-2.1	0.1	-1.2	-0.8	1.1	0.8
Leg fat percentage (right)	0.6	2.1	7.5	-2.7	0.5	-1.0	-1.3	0.7	-1.0	-2.1	-2.7	-0.7	1.1	-1.1	1.1	-0.7	-2.2	0.1	-1.5	-1.0	1.1	0.8
Arm fat-free mass (right)	0.2	1.2	4.4	-0.2	1.3	2.1	-0.5	1.0	-0.5	-0.0	1.1	1.2	0.5	-0.8	1.1	1.3	0.3	0.9	1.8	1.9	0.6	0.6
Exposure to tobacco smoke outside home	4.3	5.8	9.4	-3.0	-0.2	1.3	-3.0	2.0	-3.0	-3.1	-0.0	1.8	3.0	-2.9	2.8	1.9	-2.9	2.5	1.5	1.2	2.9	2.9
Comparative body size at age 10	0.2	0.5	3.7	-0.8	0.5	-1.9	0.4	-0.1	-0.3	-0.6	-1.1	-0.5	0.4	-0.4	0.3	-0.8	-0.4	-0.3	-0.8	-1.1	0.4	0.3
Number of full brothers	1.5	1.9	4.7	-1.8	0.6	2.2	-1.1	1.0	-1.6	-1.7	-0.2	1.1	1.6	-1.7	1.6	1.0	-1.5	1.3	0.8	1.0	1.7	1.6
Worry too long after embarrassment	0.1	0.2	0.7	-0.7	0.1	-0.1	-0.3	0.8	-0.4	-0.4	-0.4	0.4	0.4	-0.4	0.3	0.3	-0.4	0.3	0.1	0.3	0.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.1	-0.4	-0.7	-0.2	-0.3	0.5	0.1	-0.3	-0.8	-0.5	0.2	-0.3	-0.3	-0.1	-0.4	-0.8	-0.5	-0.4	-0.5
Wheeze or whistling in the chest in last year	2.9	5.2	17.9	-1.4	1.2	4.2	-2.4	2.1	-2.3	-1.9	1.5	2.2	2.3	-2.3	2.3	2.4	-1.6	2.5	2.5	2.1	2.2	2.4
Number of children fathered	0.4	0.4	1.6	-0.2	1.2	0.2	0.0	0.4	-0.6	-0.5	0.3	0.7	0.6	-0.6	0.6	1.0	-0.3	0.8	0.8	0.8	0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	9.1	-0.2	2.2	0.4	-1.4	2.1	-1.8	-1.0	2.4	2.6	1.8	-1.8	2.0	2.8	-0.7	2.5	3.0	2.9	1.8	2.0
Age at first live birth	2.4	4.3	9.7	2.2	0.3	-0.7	2.6	-3.1	2.2	2.1	-0.9	-1.7	-2.1	2.4	-2.5	-2.0	2.0	-2.1	-1.7	-2.3	-2.2	-2.1
Pulse wave peak to peak time	0.3	0.4	0.9	-0.9	-0.4	0.6	-0.9	0.9	-0.6	-0.8	-0.7	-0.0	0.7	-0.7	0.7	0.2	-0.9	0.4	-0.0	0.0	0.6	0.6
Health satisfaction	0.4	0.5	1.3	-1.1	0.5	0.9	-0.4	0.1	-0.9	-0.9	-0.2	0.8	0.9	-0.7	0.5	0.5	-1.1	0.7	0.3	0.1	1.0	0.9
Shortness of breath walking on level ground	0.4	0.5	2.0	-0.1	-1.4	-0.3	0.2	-1.1	0.4	-0.0	-0.9	-0.9	-0.4	0.6	-0.8	-0.5	-0.5	-0.6	-0.8	-1.3	-0.4	-0.5
Qualifications: College or University degree	3.5	11.1	20.5	3.9	-0.6	-2.7	4.5	-3.5	4.0	4.3	0.3	-2.2	-3.9	4.0	-3.9	-2.8	4.0	-3.2	-1.7	-1.8	-4.0	-3.8
Eye problems/disorders: None of the above	0.7	0.8	4.3	0.1	-0.5	-2.1	0.6	-0.3	0.8	0.3	-0.4	-1.2	-0.8	0.7	-0.6	-1.1	0.1	-1.0	-1.2	-1.5	-0.7	-0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.2	-1.5	0.2	1.0	-1.0	1.1	-1.3	-1.2	-0.1	0.9	1.3	-1.3	1.5	0.8	-0.9	1.0	0.4	1.3	1.2	1.2
Emphysema/chronic bronchitis	0.2	0.2	1.3	-0.3	-1.2	-0.7	-0.1	0.1	-0.5	-0.2	0.4	0.8	0.4	-0.2	0.1	0.5	-0.2	0.5	0.5	0.5	0.4	0.4
Medication for pain relief, constipation, heartburn	4.1	7.0	9.5	2.5	-0.5	-2.4	3.0	-2.3	3.1	2.7	-1.3	-2.6	-3.0	3.1	-3.0	-2.9	2.4	-2.9	-2.3	-2.6	-3.1	-3.0
Neck or shoulder pain in last month	4.1	5.8	10.8	-2.3	0.7	3.3	-3.0	2.3	-2.8	-2.7	0.6	1.9	2.9	-2.9	2.6	2.2	-2.4	2.6	1.6	1.6	2.7	2.8
Medication: Blood pressure	0.8	1.4	5.0	-0.6	1.2	-1.5	0.6	-0.6	0.5	-0.3	-2.2	-1.6	-0.5	0.5	-0.6	-1.4	-0.5	-1.1	-2.1	-1.9	-0.6	-0.7
Angina (self-reported)	6.2	8.1	14.6	-2.3	2.4	3.8	-2.9	2.5	-3.2	-2.9	1.6	2.6	3.3	-3.1	3.2	2.7	-2.4	3.1	2.6	2.2	3.1	3.3
Migraine (self-reported)	2.9	3.6	7.1	1.3	-0.9	-1.3	1.8	-2.6	1.8	1.4	-1.9	-1.9	-1.8	2.1	-2.2	-2.5	1.2	-2.1	-1.8	-2.7	-1.9	-1.8
Medication: Ibuprofen	0.3	0.4	1.4	-0.2	-0.7	1.2	-0.6	-0.3	-0.4	0.1	0.3	1.1	0.3	-0.1	0.1	0.5	0.2	0.6	0.9	1.0	0.3	0.4
Medication: Allopurinol	0.4	0.5	1.5	1.1	0.1	1.2	0.7	-0.3	0.7	0.8	0.3	-0.6	-0.7	0.8	-0.9	-0.2	0.8	-0.5	-0.3	-0.3	-0.9	-0.7
Medication: Omeprazole	0.6	0.7	1.8	-0.1	-0.1	-0.3	-0.9	1.0	-0.7	-0.3	1.0	0.6	0.7	-1.0	1.0	1.3	-0.1	1.0	1.1	1.3	0.6	0.7
Medication: Seretide 50 evohaler	0.7	0.8	2.9	0.9	0.3	0.4	1.1	-0.0	1.1	1.4	0.5	-0.0	-1.1	1.0	-0.9	-0.7	1.7	-0.8	0.3	0.6	-1.0	-0.9
Mean time to correctly identify matches	0.3	0.6	1.9	-1.4	-0.3	-0.1	-0.6	0.3	-0.9	-1.3	-0.9	0.1	0.9	-0.7	0.5	-0.3	-1.0	0.2	-1.0	-0.5	0.9	0.7
Heart disease (mother)	1.6	2.0	5.6	-1.6	-0.1	2.4	-1.6	1.1	-1.6	-1.9	0.4	0.5	1.6	-1.7	1.5	1.3	-1.8	1.2	0.4	0.5	1.5	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	8.8	-0.8	0.5	3.0	-1.3	0.9	-0.8	-1.0	0.6	0.5	0.8	-1.0	1.0	0.9	-1.1	0.7	0.4	0.6	0.9	0.7
Whole body fat mass	0.3	1.4	5.1	-2.3	1.8	-0.7	-0.7	0.8	-0.9	-1.6	-2.0	-0.3	0.9	-1.2	1.4	-0.2	-1.7	0.3	-0.6	-0.2	1.1	0.8
Leg fat mass (right)	0.5	1.8	5.9	-2.4	1.5	-0.4	-1.3	1.1	-1.2	-1.9	-1.9	-0.2	1.2	-1.4	1.6	0.0	-2.0	0.5	-0.6	-0.2	1.3	1.0
Arm predicted mass (right)	0.3	1.4	5.1	-0.5	1.1	2.3	-0.7	1.2	-0.7	-0.2	1.0	1.3	0.6	-1.0	1.3	1.5	0.1	1.0	1.8	2.0	0.8	0.8
Pulse rate, automated reading	0.0	0.1	1.4	-0.3	-0.5	-1.2	0.3	0.0	0.1	0.1	-0.2	-0.0	-0.2	0.1	0.1	-0.2	-0.1	-0.1	-0.3	0.1	-0.1	-0.2
Alcohol intake frequency.	1.7	4.0	7.5	-2.7	0.0	2.1	-2.4	1.9	-2.4	-2.6	-1.3	1.3	2.3	-2.4	2.2	1.2	-2.4	1.7	1.1	0.9	2.4	2.2
Comparative height size at age 10	0.4	2.4	7.1	2.4	1.4	0.1	2.1	-0.3	1.0	2.3	2.4	1.4	-1.0	0.9	-0.7	0.8	2.7	0.1	2.1	2.0	-0.9	-0.7
Number of full sisters	3.8	4.6	7.0	-2.1	2.3	0.9	-2.2	1.8	-2.3	-2.3	0.4	2.2	2.3	-2.4	2.3	2.2	-2.6	2.4	2.1	1.3	2.6	2.4
Suffer from ‘nerves’	0.5	0.8	3.2	-0.7	1.5	0.6	-1.2	1.8	-0.7	-0.8	0.3	0.5	0.7	-0.9	1.1	0.8	-0.8	0.7	0.7	0.8	0.7	0.7
Overall health rating	1.9	4.1	5.6	-2.1	0.9	1.5	-2.1	2.2	-2.4	-2.1	0.4	2.1	2.3	-2.2	2.3	1.9	-1.8	2.2	2.0	2.0	2.3	2.4
Chest pain or discomfort	3.5	5.0	11.9	-2.4	0.1	3.5	-2.9	2.5	-2.4	-2.4	0.6	1.8	2.4	-2.4	2.5	1.9	-2.3	2.2	1.4	1.7	2.4	2.3
Had major operations	0.7	0.8	4.0	-1.0	-1.1	-0.3	-0.3	-0.6	0.1	-0.6	-2.0	-1.0	-0.1	0.2	-0.0	-1.2	-1.0	-0.6	-1.5	-1.5	-0.1	-0.3
Age at last live birth	0.9	1.3	3.8	1.3	0.4	-0.9	1.9	-1.8	0.9	1.0	-1.0	-0.6	-0.9	1.2	-1.4	-1.0	0.9	-0.9	-0.8	-1.5	-0.9	-0.9
Family relationship satisfaction	1.3	1.6	2.9	-1.6	0.5	0.4	-1.3	1.4	-1.6	-1.7	-0.6	1.0	1.6	-1.4	1.3	0.8	-1.6	1.3	0.6	0.3	1.5	1.6
Leg pain on walking	1.9	2.4	3.8	-1.3	1.9	1.2	-1.6	1.6	-1.5	-1.5	1.1	1.5	1.5	-1.6	1.5	2.0	-1.7	1.8	1.5	1.3	1.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.2	7.7	-1.6	-0.2	2.5	-2.8	1.9	-1.9	-2.2	0.5	1.0	1.8	-2.0	2.0	1.8	-2.3	1.7	1.0	0.9	1.9	1.8
Commuting to job workplace: Car/motor vehicle	2.0	2.3	6.4	-0.5	-2.5	-0.4	0.4	-1.0	1.1	-0.1	-2.3	-2.3	-1.1	1.0	-1.2	-1.9	-0.5	-1.8	-2.3	-2.1	-1.0	-1.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	0.4	-0.1	0.3	0.3	-0.2	0.1	0.4	0.9	0.6	-0.1	0.4	-0.4	0.3	0.6	0.2	0.3	0.8	-0.2	-0.0
Medication: Aspirin	0.2	0.2	0.5	-0.1	0.5	-0.4	-0.2	0.3	-0.6	-0.4	0.5	0.5	0.6	-0.6	0.7	0.3	-0.1	0.6	0.5	0.4	0.6	0.6
Supplements: Vitamin C	0.4	0.5	1.3	-1.0	-0.9	-0.3	-0.2	0.3	-0.9	-0.8	-1.1	0.5	0.9	-0.8	0.3	0.1	-0.5	0.4	0.4	0.0	0.9	0.9
Knee pain experienced in last month	4.2	6.6	10.1	-2.6	1.0	2.2	-3.2	2.6	-3.0	-3.1	0.9	1.8	3.0	-3.2	3.0	2.6	-2.9	2.7	1.4	1.5	3.0	3.0
Hypertension (Self-reported)	0.4	1.0	5.0	-1.4	0.0	-0.3	0.1	-0.4	-0.5	-1.2	-2.2	-0.7	0.6	-0.4	0.3	-1.0	-1.2	-0.4	-1.7	-1.7	0.6	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	4.1	-1.6	-0.3	0.8	-1.8	2.0	-1.9	-2.0	0.3	0.9	1.9	-2.0	1.9	1.6	-1.7	1.5	1.1	1.2	1.8	1.8
Illnesses of father: Heart disease	2.7	3.7	5.6	-1.8	0.7	2.4	-2.0	2.1	-2.3	-2.2	0.7	1.8	2.3	-2.0	2.0	1.9	-1.8	2.0	1.7	1.5	2.2	2.3
Illnesses of siblings: Diabetes	0.4	0.5	2.9	0.8	1.7	-1.7	0.4	0.1	0.2	0.6	0.8	0.5	-0.2	0.1	-0.1	0.3	0.7	0.2	0.5	0.4	-0.1	-0.1
Smoking status: Previous	0.2	0.2	0.6	0.1	-0.7	0.7	0.1	-0.5	-0.5	0.0	0.4	0.8	0.5	-0.3	0.0	0.4	0.2	0.6	0.6	0.1	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.7	0.8	1.2	1.1	-0.1	0.4	0.0	0.8	1.0	1.2	-0.1	-0.1	0.3	1.1	1.0	0.6	2.2	1.9	0.0	0.2
Whole body fat-free mass	0.1	0.6	3.3	-0.1	1.3	1.8	-0.0	0.5	-0.1	0.3	0.7	0.8	0.1	-0.4	0.6	0.9	0.4	0.5	1.3	1.5	0.2	0.2
Leg fat-free mass (right)	0.1	0.4	3.1	-0.5	1.8	1.2	-0.1	0.4	-0.2	-0.1	0.1	0.3	0.2	-0.5	0.8	0.5	-0.0	0.3	0.8	0.9	0.3	0.3
Arm fat percentage (left)	0.7	2.7	10.0	-3.2	1.3	-1.5	-1.1	0.9	-1.3	-2.4	-2.8	-0.7	1.4	-1.5	1.5	-0.6	-2.6	0.3	-1.3	-0.9	1.4	1.1
Average weekly red wine intake	0.2	0.2	0.6	0.7	-0.7	-0.1	0.4	-0.7	0.5	0.3	-0.4	-0.7	-0.4	0.3	-0.4	-0.3	0.4	-0.6	-0.4	-0.6	-0.4	-0.4
Handedness (chirality/laterality): Left-handed	3.5	4.3	6.8	-1.3	2.6	2.6	-1.8	1.7	-2.0	-1.6	1.7	2.2	2.0	-2.2	2.1	2.5	-1.9	2.4	1.7	1.9	2.2	2.0
Mood swings	1.5	2.7	4.7	-2.0	-1.7	0.3	-2.1	2.0	-1.9	-2.2	-1.1	0.6	1.9	-2.0	1.8	1.2	-2.1	1.4	0.3	0.3	1.9	1.8
Loneliness, isolation	1.4	1.9	3.7	-1.9	0.5	-0.8	-1.7	1.8	-1.5	-1.7	-0.5	1.0	1.4	-1.6	1.7	1.1	-1.9	1.3	0.5	0.7	1.6	1.4
Long-standing illness, disability or infirmity	0.5	0.7	2.5	-0.6	0.2	1.6	-0.9	0.8	-1.0	-0.8	0.2	0.6	0.9	-1.0	0.7	0.8	-0.6	0.8	1.0	0.3	0.9	1.0
Ever had bowel cancer screening	0.9	1.0	3.4	-0.7	1.8	1.7	-0.8	0.3	-0.9	-0.8	0.8	1.1	1.0	-0.8	0.7	1.1	-0.9	1.1	0.9	0.8	1.0	1.0
Diabetes diagnosed by doctor	0.4	0.6	1.9	-1.0	-0.5	-0.7	-0.4	0.2	-0.8	-1.2	-1.4	-0.5	0.8	-0.8	0.7	-0.4	-1.0	-0.0	-0.9	-1.0	0.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.0	0.2	0.0	-0.7	0.2	-0.5	-0.3	0.7	0.8	0.5	-0.6	0.7	0.6	-0.1	0.7	0.9	0.5	0.6	0.6
Friendships satisfaction	0.8	1.0	3.9	-0.6	-0.3	-2.0	0.4	-0.4	0.3	-0.3	-1.9	-1.4	-0.3	0.2	-0.5	-1.3	-0.4	-1.0	-1.6	-1.7	-0.2	-0.5
Qualifications: nursing, teaching	2.1	3.3	5.1	1.4	-0.3	-0.5	2.1	-2.1	2.1	1.9	-0.3	-1.5	-2.1	2.3	-2.2	-2.2	1.9	-2.1	-1.8	-1.5	-2.1	-2.1
Commuting to job workplace: Walk	1.2	1.3	3.3	1.6	0.7	-0.5	1.4	-1.1	1.3	1.6	0.3	-0.5	-1.3	1.3	-1.1	-1.2	1.8	-1.1	-0.4	-0.5	-1.3	-1.2
Eye problems/disorders: Cataract	0.6	0.7	2.4	0.3	0.4	0.3	-0.8	0.6	-0.8	-0.1	0.8	1.2	0.8	-0.6	0.7	1.2	0.2	1.1	1.5	1.6	0.5	0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.5	-0.8	-0.8	1.6	-1.2	0.5	-1.2	-1.0	0.4	0.7	1.1	-1.4	1.1	1.0	-0.8	1.0	0.7	0.6	1.3	1.1
Medication for cholesterol	0.1	0.2	1.2	0.5	0.4	1.1	-0.0	0.2	0.3	0.5	0.7	-0.0	-0.3	0.2	-0.2	0.6	0.3	0.1	0.5	0.7	-0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.2	-0.6	1.5	2.0	-1.6	1.7	-1.2	-1.0	1.5	1.6	1.2	-1.3	1.3	2.0	-0.9	1.7	1.8	1.9	1.2	1.3
Back pain experienced in last month	2.9	4.2	7.2	-2.3	-0.4	1.5	-2.7	2.2	-2.4	-2.2	0.1	1.6	2.3	-2.4	2.2	2.3	-2.1	2.2	1.6	1.9	2.3	2.3
Mineral and other dietary supplements	0.0	0.0	0.3	-0.1	-0.1	0.1	-0.5	0.5	0.1	-0.1	0.2	-0.3	-0.2	-0.1	0.1	-0.0	-0.2	-0.1	-0.2	0.0	-0.0	-0.2
Breast cancer (self-reported)	1.2	1.4	3.6	-0.3	1.8	1.0	-0.8	1.9	-0.8	-0.5	1.7	0.9	0.8	-1.1	1.2	1.6	-0.2	1.1	1.5	1.8	0.8	0.9
Asthma (self-reported)	0.1	0.1	1.1	0.2	0.1	1.0	-0.7	0.2	-0.1	-0.1	-0.5	0.2	0.1	0.1	0.1	0.2	-0.3	0.3	0.3	-0.2	-0.0	0.1
Osteoporosis (self-reported)	1.2	1.5	3.3	1.7	-0.4	-1.1	1.8	-1.6	1.2	1.6	0.8	-0.2	-1.2	1.4	-1.3	-1.0	1.7	-0.9	-0.7	-0.6	-1.2	-1.2
Osteoarthritis (self-reported)	2.3	3.0	7.0	-0.1	1.0	0.1	-1.4	1.7	-1.6	-0.8	2.4	2.2	1.6	-1.8	1.8	2.4	-0.6	2.1	2.6	2.3	1.6	1.8
Medication: Aspirin	0.4	0.6	1.3	-0.6	0.5	-0.4	-0.5	0.8	-1.0	-0.9	0.3	0.6	1.0	-1.0	1.2	0.6	-0.6	0.8	0.4	0.5	0.9	0.9
Medication: Gliclazide	0.3	0.3	1.7	-0.3	-0.2	-0.2	-0.1	-0.6	0.3	-0.2	-1.3	-0.7	-0.3	0.3	-0.4	-0.6	-0.4	-0.5	-0.8	-1.0	-0.2	-0.4
Illnesses of father: None of the above (group 1)	3.9	4.8	7.1	1.2	-2.0	-1.8	2.1	-2.5	2.4	2.0	-1.7	-2.4	-2.4	2.3	-2.2	-2.7	1.7	-2.5	-2.4	-2.1	-2.4	-2.5
Smoking status: Current	0.2	0.4	2.3	-0.8	-1.1	-1.5	-0.2	-0.3	-0.0	-0.4	-0.6	-0.3	-0.0	-0.0	-0.1	-0.6	-0.5	-0.3	-1.0	-0.7	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.5	0.6	1.4	-0.0	-0.4	0.9	-0.8	0.1	2.4	2.2	0.8	-0.6	0.9	1.6	0.2	1.5	2.2	2.0	0.8	1.0
Whole body water mass	0.1	0.7	3.7	-0.1	1.3	1.9	-0.1	0.6	-0.1	0.2	0.7	0.8	0.1	-0.4	0.6	0.9	0.4	0.5	1.2	1.5	0.2	0.2
Leg predicted mass (right)	0.1	0.4	3.0	-0.5	1.7	1.2	-0.0	0.3	-0.2	-0.1	0.1	0.3	0.2	-0.5	0.8	0.5	0.0	0.3	0.8	0.9	0.3	0.2
Arm fat mass (left)	0.5	2.1	7.5	-2.7	1.6	-0.4	-1.2	1.3	-1.4	-2.1	-1.8	0.1	1.4	-1.6	1.8	0.1	-2.1	0.7	-0.3	0.2	1.5	1.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	0.2	-0.5	0.3	0.3	-0.6	0.0	0.1	-0.9	-0.4	-0.1	0.1	-0.1	-0.6	0.2	-0.3	-0.5	-0.8	-0.1	-0.1
Average weekly champagne plus white wine intake	0.4	0.5	2.3	0.9	1.3	0.0	1.4	-1.5	0.4	0.6	0.5	0.0	-0.4	0.6	-0.6	-0.4	0.8	-0.4	-0.4	-0.4	-0.4	-0.4
Miserableness	1.0	1.8	7.8	-1.8	-2.8	0.2	-1.5	-0.1	-1.1	-1.7	-1.9	-0.9	1.0	-1.0	0.7	-0.4	-1.9	0.0	-1.3	-1.7	1.0	0.8
Guilty feelings	2.1	3.2	4.9	-1.2	1.2	1.5	-1.7	1.8	-1.9	-1.5	1.1	2.0	1.9	-2.0	2.0	2.2	-1.5	2.1	1.9	1.7	2.0	1.9
Wears glasses or contact lenses	0.4	0.5	1.8	0.4	0.4	0.2	1.2	-1.3	0.6	0.5	0.2	-0.5	-0.5	0.8	-1.0	-0.8	0.4	-0.6	-0.5	-1.1	-0.6	-0.5
Ever taken oral contraceptive pill	4.0	4.4	7.7	2.3	-2.1	-1.5	2.4	-2.8	2.1	2.2	-1.3	-1.6	-2.1	2.4	-2.6	-1.9	2.0	-2.0	-1.6	-2.2	-2.2	-2.1
Hearing aid user	0.2	0.2	0.8	0.7	0.2	0.2	-0.5	0.6	-0.1	0.2	0.8	0.3	0.1	-0.3	0.7	0.6	0.3	0.4	0.9	0.8	0.0	0.2
Mother’s age at death	2.2	2.8	6.1	0.7	-2.0	-0.5	0.7	-1.5	1.7	0.9	-1.8	-2.5	-1.7	1.5	-1.8	-1.9	0.6	-2.2	-2.3	-2.0	-1.6	-1.8
Financial situation satisfaction	0.5	0.7	2.0	-1.4	0.1	-0.2	-0.7	1.1	-0.9	-1.2	-0.7	-0.1	0.9	-1.0	0.8	0.5	-1.3	0.4	-0.2	0.1	0.9	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.2	-0.8	-0.1	-0.6	0.7	-0.5	-0.2	0.8	0.2	0.5	-0.5	0.6	0.5	0.0	0.5	0.5	0.5	0.3	0.5
Commuting to job workplace: Public transport	2.3	2.8	6.4	2.1	1.0	-2.0	2.5	-1.6	1.6	2.5	0.9	0.0	-1.6	2.0	-2.0	-1.2	2.5	-1.1	-0.4	-0.6	-1.6	-1.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.9	0.3	0.5	0.9	-0.3	-0.5	-0.1	0.0	0.0	0.1	0.1	-0.4	0.2	0.3	-0.1	0.3	0.4	-0.2	0.3	0.1
Medication: Blood pressure	0.1	0.2	0.5	-0.5	0.3	0.3	0.1	0.1	-0.6	-0.7	-0.4	0.0	0.6	-0.7	0.6	-0.2	-0.4	0.1	-0.2	-0.3	0.7	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	-1.2	0.5	1.0	-1.2	0.4	-0.6	-1.1	-1.0	-0.4	0.6	-0.8	0.5	-0.0	-0.9	0.2	-0.4	-0.2	0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.6	0.4	0.8	-0.6	0.4	-0.1	0.0	0.3	0.2	0.2	0.0	-0.1	0.2	0.3	0.5	0.1	0.7	0.4	0.0	0.1
High cholesterol (Self-reported)	0.7	1.3	7.4	0.4	-0.5	-2.7	0.9	-0.7	0.6	0.3	-1.4	-1.0	-0.6	0.8	-0.8	-1.4	0.3	-1.0	-1.6	-1.8	-0.6	-0.7
Medication: Bendroflumethiazide	0.5	0.8	3.8	-1.6	0.9	0.8	-0.1	-0.4	-0.3	-1.1	-1.9	-0.6	0.4	-0.3	0.4	-0.9	-1.2	-0.4	-1.2	-1.1	0.5	0.2
Medication: Paracetamol	0.1	0.1	0.6	-0.3	0.5	0.8	-0.5	0.2	-0.3	-0.3	0.2	0.3	0.3	-0.2	0.4	0.5	-0.3	0.3	0.4	0.3	0.2	0.4
Medication: Lisinopril	1.3	1.7	4.4	1.6	-0.0	-0.5	2.0	-2.1	1.2	1.4	-0.5	-0.8	-1.2	1.3	-1.5	-1.1	1.6	-1.2	-0.9	-1.3	-1.2	-1.2
Medication: Atorvastatin	0.2	0.2	0.6	0.4	0.4	-0.8	0.5	-0.5	0.4	0.1	-0.7	-0.5	-0.4	0.3	-0.1	-0.6	0.1	-0.4	-0.5	-0.8	-0.3	-0.4
Illnesses of father: High blood pressure	0.9	1.1	2.6	-1.3	1.6	0.4	-1.1	1.5	-1.1	-1.5	0.3	0.5	1.2	-1.0	1.3	0.6	-1.4	0.9	0.2	0.2	1.1	1.1
Alcohol drinker status: Never	1.0	1.2	3.2	-0.6	0.8	1.2	-0.7	0.9	-1.3	-0.8	1.0	1.4	1.2	-1.1	0.8	1.3	-0.5	1.2	1.8	1.0	1.3	1.4
Ever smoked	0.3	0.5	5.0	-0.6	-2.2	0.3	-0.2	-0.5	-0.7	-0.6	-0.3	0.2	0.7	-0.5	0.1	-0.1	-0.4	0.3	-0.3	-0.6	0.6	0.6
Basal metabolic rate	0.1	0.5	2.6	-0.4	1.4	1.6	-0.2	0.6	-0.2	-0.0	0.3	0.7	0.2	-0.5	0.7	0.7	0.1	0.5	1.0	1.3	0.3	0.3
Leg fat percentage (left)	0.6	2.3	8.0	-2.8	0.8	-1.0	-1.4	0.8	-1.2	-2.3	-2.8	-0.8	1.2	-1.4	1.4	-0.7	-2.4	0.1	-1.5	-1.1	1.3	0.9
Arm fat-free mass (left)	0.2	1.0	5.1	-0.3	1.3	2.3	-0.6	0.9	-0.5	-0.1	0.9	1.1	0.4	-0.7	1.0	1.0	0.2	0.8	1.4	1.7	0.6	0.5
Number of operations (self-reported)	0.5	0.8	1.6	-0.5	0.2	0.5	-1.2	0.9	-0.9	-0.9	1.1	0.7	0.9	-1.0	1.2	1.0	-1.0	1.0	0.7	0.6	1.0	0.9
Average weekly beer plus cider intake	1.8	2.6	4.0	-2.0	-1.0	0.5	-1.8	1.8	-1.9	-1.5	-0.2	1.8	1.9	-1.8	1.7	1.3	-1.2	1.7	1.7	1.7	1.9	1.9
Irritability	0.4	0.7	1.8	-0.9	-1.0	1.1	-1.3	1.0	-0.9	-1.0	-0.2	0.3	0.9	-1.1	0.9	0.7	-0.9	0.6	0.5	0.0	1.0	0.8
Risk taking	1.0	1.5	2.3	-1.0	0.6	0.4	-0.8	1.1	-1.4	-1.2	0.6	1.5	1.4	-1.4	1.3	1.3	-1.1	1.5	1.5	1.1	1.5	1.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	4.4	0.4	1.3	2.1	-0.1	-0.1	-0.1	0.2	0.8	0.6	0.1	0.0	-0.1	0.4	0.2	0.4	0.7	0.4	0.0	0.1
Fractured/broken bones in last 5 years	0.1	0.2	0.8	0.3	0.5	0.3	0.1	-0.5	-0.2	0.1	0.6	0.9	0.2	-0.0	0.1	0.3	-0.0	0.6	0.8	0.2	0.3	0.3
Age started oral contraceptive pill	4.6	5.7	11.8	3.4	0.7	-1.0	3.3	-3.1	2.6	3.3	0.9	-1.0	-2.6	2.8	-2.9	-1.7	3.3	-1.9	-0.7	-1.1	-2.7	-2.5
Diastolic blood pressure, automated reading	0.4	1.1	3.0	-1.5	1.5	0.6	-0.9	1.2	-1.0	-1.6	-0.3	0.3	1.1	-1.1	1.3	0.3	-1.7	0.7	-0.3	-0.2	1.1	1.0
Ever depressed for a whole week	0.6	0.7	2.1	-1.2	-1.2	-0.8	-1.0	-0.5	-0.8	-1.1	-1.2	-0.3	0.8	-0.5	0.5	0.0	-1.4	0.4	-0.4	-0.7	0.6	0.7
Unable to work because of sickness or disability	1.1	1.4	2.5	-0.8	0.1	1.5	-1.5	1.6	-1.2	-1.1	0.9	0.9	1.1	-1.4	1.4	1.4	-0.9	1.1	0.9	1.3	1.2	1.1
Commuting to job workplace: Cycle	0.5	0.6	2.3	0.9	0.8	0.6	1.3	-1.5	0.7	0.7	0.7	-0.5	-0.6	0.8	-0.8	-0.2	0.5	-0.4	0.0	-0.6	-0.8	-0.6
Myopia	0.4	0.6	1.4	1.2	0.6	-0.5	0.5	-1.0	0.9	1.1	0.9	-0.2	-0.9	0.8	-0.8	-0.3	1.0	-0.5	-0.2	-0.4	-0.8	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.7	1.4	-1.0	-0.1	0.3	-0.1	0.8	1.4	1.6	0.4	-0.9	0.9	-0.8	0.6	1.3	-0.1	1.3	1.2	-0.9	-0.7
Cholesterol lowering medication	0.3	0.4	2.2	0.2	-0.2	-1.5	0.5	-0.7	0.3	0.1	-0.9	-0.5	-0.3	0.4	-0.3	-0.9	0.2	-0.6	-0.9	-1.0	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	4.9	-0.3	0.4	0.9	-1.3	1.6	-1.5	-0.8	1.8	1.8	1.5	-1.7	1.8	2.2	-0.5	1.9	2.0	2.2	1.5	1.6
Pain experienced in last month	3.1	5.2	10.2	3.1	0.7	-1.8	3.1	-2.1	2.6	3.1	1.4	-1.1	-2.6	2.6	-2.3	-1.8	3.2	-2.1	-0.8	-0.8	-2.6	-2.5
Supplements: Calcium	2.2	2.5	6.8	2.6	0.6	-1.5	1.9	-2.2	1.3	2.4	1.3	0.9	-1.3	1.8	-1.8	-0.9	2.6	-0.6	0.5	-0.3	-1.3	-1.1
Basal cell carcinoma (self-reported)	1.4	1.6	3.3	1.8	-0.2	0.4	1.5	-1.4	1.6	1.6	-0.2	-1.2	-1.6	1.3	-1.4	-0.7	1.5	-1.2	-0.8	-0.9	-1.6	-1.6
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.2	-1.5	1.4	-0.4	-2.0	1.7	-1.7	-1.8	0.6	1.1	1.7	-1.8	1.8	1.4	-1.7	1.6	0.7	0.7	1.8	1.6
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	6.7	-0.0	2.6	1.5	-0.9	1.3	-1.6	-0.9	2.3	2.6	1.7	-1.6	1.6	2.5	-0.6	2.3	2.6	2.5	1.6	1.9
Heart disease (siblings)	3.4	4.2	7.2	-1.8	1.4	2.2	-2.2	2.7	-2.2	-2.2	0.8	1.4	2.2	-2.5	2.5	2.3	-1.9	2.1	1.6	1.7	2.2	2.2
Alcohol drinker status: Previous	3.5	4.0	6.7	-2.6	-0.2	1.3	-2.0	1.9	-2.5	-2.5	-0.7	1.9	2.5	-2.3	2.3	1.4	-2.0	1.9	1.3	1.6	2.5	2.4
Pack years of smoking	0.2	0.4	1.5	-1.2	0.9	-0.8	-0.6	0.3	-0.5	-0.8	-0.3	0.1	0.5	-0.5	0.5	-0.1	-0.8	0.3	-0.4	-0.1	0.5	0.4
Impedance of whole body	0.6	3.2	6.9	2.6	-0.3	-2.4	2.3	-1.8	2.1	2.3	0.1	-1.0	-2.0	2.2	-2.1	-1.1	2.0	-1.4	-0.6	-0.7	-2.1	-1.9
Leg fat mass (left)	0.5	2.0	6.2	-2.5	1.7	-0.3	-1.4	1.2	-1.3	-2.0	-1.9	-0.2	1.3	-1.6	1.7	0.1	-2.0	0.6	-0.5	-0.2	1.4	1.1
Arm predicted mass (left)	0.3	1.5	5.8	-0.5	1.3	2.4	-0.9	1.3	-0.8	-0.4	1.0	1.4	0.7	-1.1	1.3	1.4	-0.1	1.1	1.7	2.0	0.9	0.9