Hub : Genes

ANXA4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0944	0.0497	4.0e-03	0.018	NA	0.002	NA	0.009	1.4e-02	NA	2.2e-01	NA	5.8e-02
2	GTEx	Lung	0.2214	0.0753	8.0e-05	0.028	NA	0.047	NA	-0.002	3.3e-03	NA	1.6e-04	NA	5.2e-01
3	GTEx	Nerve Tibial	0.2079	0.1266	2.2e-03	0.003	NA	0.006	NA	0.009	1.8e-01	NA	1.0e-01	NA	6.9e-02
4	METSIM	Adipose	0.0616	0.0237	1.3e-05	0.037	0.022	0.039	0.03	0.039	2.7e-06	2.5e-04	1.6e-06	2.2e-05	1.4e-06
5	YFS	Blood	0.1297	0.0333	5.6e-17	0.061	0.054	0.060	0.06	0.069	2.4e-19	3.1e-17	7.0e-19	6.2e-19	1.5e-21
6	TCGA	Breast Invasive Carcinoma	0.0109	0.0071	4.4e-03	0.006	0.011	0.005	NA	0.006	1.7e-02	2.3e-03	3.3e-02	NA	1.7e-02
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0975	0.0370	2.9e-12	0.102	0.116	0.121	NA	0.121	1.7e-11	6.2e-13	1.8e-13	NA	1.8e-13
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0570	0.0360	3.5e-03	0.011	0.046	0.032	NA	0.005	6.8e-02	1.2e-03	5.8e-03	NA	1.5e-01
9	TCGA	Brain Lower Grade Glioma	0.0745	0.0388	7.3e-04	0.017	0.023	0.013	NA	0.010	4.5e-03	1.1e-03	1.0e-02	NA	2.1e-02
10	TCGA	Thyroid Carcinoma	0.0340	0.0210	3.3e-03	0.039	0.017	0.033	NA	0.034	1.0e-04	7.5e-03	3.2e-04	NA	3.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.1	1.7	3.0	1.3	-1.7	1.0	-1.0	-0.9	-1.2	-1.4	-1.5	1.5	1.4
Bipolar Disorder or Schizophrenia	1.1	2.7	5.7	1.8	-2.4	1.2	-1.0	-1.1	-1.8	-1.9	-2.1	1.0	1.6
Depressed Affect (Nagel 2018)	0.1	0.3	1.2	0.4	0.6	-0.4	0.1	0.5	-0.5	0.1	-0.0	1.1	0.5
Depression (Nagel 2018)	0.3	0.4	1.4	0.3	0.4	-0.8	0.9	0.8	-0.1	-0.1	0.1	1.2	0.6
Intelligence (Savage-Jansen 2018)	2.4	7.4	18.8	-3.6	0.5	-2.4	2.3	1.8	1.9	0.9	2.7	-4.3	-4.0
Neuroticism (Nagel 2018)	0.1	0.3	1.6	0.7	0.3	0.2	-0.1	0.3	-0.7	-0.2	-0.1	1.3	0.5
Schizophrenia (2018)	0.6	1.2	2.7	1.2	-1.6	0.8	-0.5	-0.7	-1.3	-1.3	-1.5	0.1	0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.8	0.2	0.1	0.4	-0.2	-0.5	-0.5	-0.4	-0.3	-0.9	-0.7
Worry (Nagel 2018)	0.3	0.5	1.6	0.9	0.5	0.5	-0.5	-0.3	-0.8	-0.2	-0.8	1.2	1.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.2	-0.0	-0.9	0.0	0.3	-0.3	-1.3	-1.1	-0.1	-1.4	-1.5
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.2	-0.3	0.2	-0.3	-0.3	-0.5	-1.1	-0.5	0.3	0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.1	-0.5	-0.0	0.3	-0.1	-0.8	-1.0	-0.2	-0.5	-0.7
Crohns Disease (2017)	1.4	3.1	9.2	1.3	-2.4	-0.9	-0.6	-1.1	-2.9	-3.0	-1.9	-0.0	0.2
Irritable Bowel Disease (IBD)	1.1	2.5	7.1	1.4	-2.4	-0.4	-0.4	-0.9	-2.5	-2.7	-1.8	-0.5	0.3
Ulcerative Colitis (UC)	0.3	0.5	1.4	0.9	-1.2	0.1	0.3	0.1	-1.0	-1.0	-0.8	-0.4	0.4
Major Depression (MDD)	1.5	1.8	3.6	1.2	-1.1	0.8	-1.7	-1.8	-1.8	-1.9	-1.1	0.6	-0.2
Reaction Time	0.9	1.7	4.2	1.2	-1.1	-0.2	-0.9	-1.2	-1.8	-1.7	-2.0	0.0	1.1
Verbal and Numeric Reasoning (VNR)	3.3	7.8	21.6	-4.0	0.9	-1.3	1.8	1.5	2.5	1.4	3.0	-4.7	-3.9
Breast Cancer	2.4	5.7	12.7	0.7	-3.5	-3.6	1.4	-0.1	-3.5	-3.1	-1.3	-1.6	-1.8
Ovarian Cancer	0.7	0.9	2.3	1.1	-0.8	0.7	-1.0	-0.8	-1.5	-1.3	-1.0	0.1	0.3
Prostate Cancer	0.3	0.4	2.0	0.6	-1.4	0.6	-0.3	-0.4	0.0	-0.3	-0.6	0.6	0.9
Age at First Birth	0.1	0.2	0.9	-0.5	-0.0	1.0	0.0	-0.0	0.6	0.6	0.3	0.1	0.1
Bipolar Disorder (2011)	0.2	0.2	0.4	0.4	-0.5	-0.3	0.5	0.5	-0.6	-0.3	0.1	0.3	-0.2
Body Mass Index (BMI) (2010)	0.9	1.3	2.5	-0.5	1.1	-0.8	1.2	1.5	1.4	1.6	1.5	0.5	-0.2
Coronary Artery Disease (CAD)	2.0	2.4	5.6	1.8	-1.5	0.9	-1.7	-1.4	-2.4	-1.9	-1.9	0.6	0.5
Crohns Disease (2012)	1.3	2.1	7.6	1.2	-2.0	-0.9	-0.2	-0.6	-2.8	-2.3	-1.3	0.2	-0.4
Mean Putamen Volume	0.9	1.1	2.9	-0.2	1.7	-1.6	0.1	0.5	0.6	1.4	0.9	1.3	0.2
Fasting Glucose	1.5	1.8	7.5	-0.2	2.7	-1.6	0.5	0.9	1.3	1.9	0.6	1.0	0.8
HbA1C	0.4	0.5	1.2	0.5	-0.9	0.3	-0.0	-0.1	-0.5	-0.8	-1.1	0.4	1.0
HDL Cholesterol	0.1	0.2	0.7	0.6	-0.2	0.0	-0.8	-0.3	-0.2	-0.1	-0.7	0.3	0.7
LDL Cholesterol	1.8	2.9	6.0	-1.3	1.2	-2.5	2.4	2.4	0.1	0.6	1.6	-1.2	-2.1
Lupus	0.8	1.2	3.0	0.9	-1.1	0.5	-1.3	-1.1	-1.1	-1.1	-1.7	0.4	1.2
Neuroticism (2016)	0.3	0.5	1.7	1.3	0.2	0.3	0.2	-0.2	-1.3	-0.7	-0.8	0.1	0.0
Primary Biliary Cirrhosis	1.4	2.0	5.2	2.1	0.9	0.9	-1.5	-1.0	-1.2	-0.3	-1.1	2.3	1.6
Rheumatoid Arthritis	0.8	1.1	4.6	-1.1	0.4	-2.1	1.1	1.0	-0.4	0.2	0.8	-0.8	-1.4
Schizophrenia (2014)	2.6	5.8	10.9	2.9	-3.3	1.8	-1.5	-1.9	-2.8	-2.7	-3.0	1.3	2.1
Triglycerides	0.1	0.2	1.1	-0.4	1.1	0.3	0.0	0.2	0.2	0.2	0.5	0.2	-0.2
Type 2 Diabetes (T2D) (2012)	4.1	4.7	7.8	2.6	-1.5	2.0	-1.9	-1.9	-1.8	-1.8	-2.3	2.8	2.8
Ulcerative Colitis	0.3	0.5	2.6	0.5	-1.6	-0.1	0.3	0.2	-0.7	-0.9	-0.6	-0.1	0.2
Blood Eosinophil Count	0.2	1.3	2.3	-1.1	1.2	-0.5	1.2	1.2	0.8	0.9	1.1	-1.5	-1.4
Blood Platelet Count	2.4	28.0	108.2	-5.0	5.8	4.5	-3.3	-0.5	10.4	8.1	3.2	-0.5	2.5
Blood Red Count	0.3	2.6	7.1	-2.2	1.3	-1.1	0.4	1.1	2.7	2.2	1.1	-2.0	-0.5
Blood White Count	0.2	1.4	3.2	-1.2	1.4	-0.1	1.1	0.9	0.9	0.8	1.1	-1.8	-1.6
Heel T-Score	0.3	2.3	7.9	1.1	-0.1	1.9	-2.8	-2.2	-1.0	-1.0	-1.6	0.0	1.0
BMI	1.0	5.8	10.3	2.3	-2.2	1.4	-3.2	-2.9	-2.9	-2.6	-2.7	1.3	1.4
Height	0.6	11.2	27.9	-3.8	4.6	-1.7	1.7	2.8	5.3	4.7	3.4	-1.2	-0.8
Waist Hip Ratio (WHR)	0.1	0.3	1.8	-0.6	-0.0	0.7	-0.4	-0.3	1.4	0.3	0.3	0.1	0.2
Systolic Blood Pressure	0.1	0.3	0.9	0.5	0.1	0.3	-0.5	-0.6	0.1	-0.3	-0.9	0.3	0.9
Smoking Status	0.2	0.5	1.0	-0.6	-0.6	-0.5	0.8	0.7	0.5	0.2	0.7	-0.9	-1.0
Allergy or Eczema	0.4	1.0	2.2	-1.2	1.5	-0.7	1.2	1.2	0.8	0.9	1.1	0.2	-0.6
Cardiovascular Disease	0.4	1.2	4.7	1.5	0.1	-0.6	-0.4	-0.5	-2.2	-1.4	-1.1	0.7	0.2
Hypothyroidism (self reported)	0.9	2.2	6.6	-0.8	0.6	-2.6	2.2	2.2	-0.7	-0.4	1.2	-0.5	-1.5
Respiratory disease	0.3	0.7	3.7	0.3	0.5	0.2	1.1	0.9	0.1	0.3	0.3	1.9	0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.6	0.0	0.8	-0.4	-0.1	0.5	-0.2	0.5	0.1	0.1	0.1
Lung FEV1/FVC ratio	0.3	1.4	4.8	0.4	1.0	1.6	-0.6	-0.5	-1.4	-0.9	-0.5	-2.2	-1.3
Lung FVC	0.5	2.7	12.0	-1.9	-0.6	-0.8	-0.5	0.1	3.5	2.8	1.5	0.1	0.9
Neuroticism	0.3	0.8	3.7	1.2	0.1	0.1	-0.2	0.2	-0.9	-0.2	-0.7	1.9	1.2
Chronotype (morning person)	0.8	1.9	5.3	1.1	-1.0	0.7	-1.8	-1.8	-1.1	-1.5	-2.3	-0.4	1.1
Hair Pigment	0.3	8.1	20.7	-1.5	1.9	-2.7	4.5	3.4	-1.2	-0.5	2.7	-2.7	-4.5
Tanning	0.0	0.4	1.6	0.0	-0.2	0.0	-1.3	-0.9	0.5	-0.0	-0.7	-0.1	0.9
Hand grip strength (left)	0.6	1.7	7.6	1.2	-2.8	-0.9	0.2	-0.6	-1.7	-1.4	-1.3	-0.4	0.2
Number of treatments/medications taken	1.7	3.0	5.5	-1.8	2.2	-1.5	2.3	2.4	1.4	1.4	1.9	-0.5	-1.2
Average weekly spirits intake	1.7	2.2	9.7	-1.9	0.5	-0.7	0.2	0.3	0.4	0.1	0.9	-3.1	-2.6
Sensitivity / hurt feelings	0.7	1.1	2.9	1.7	-0.3	1.2	-0.6	-1.0	-1.7	-0.9	-0.8	1.3	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.9	0.3	0.2	-0.4	1.0	0.8	-0.3	-0.2	0.1	1.4	0.4
Hearing difficulty/problems: Yes	0.5	0.8	2.3	0.1	0.7	-1.5	1.3	1.4	-0.1	0.6	0.2	0.9	0.5
Relative age of first facial hair	0.5	1.0	4.4	1.0	0.4	0.0	0.0	-0.0	0.5	0.7	-0.6	2.1	1.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.4	-0.0	-0.7	-1.2	1.1	0.6	-0.7	-0.7	0.2	-0.4	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.3	-0.0	0.2	0.5	0.1	-0.0	-0.1	0.2	0.6	0.3
Ever had hysterectomy (womb removed)	1.8	2.0	6.4	0.9	-0.7	1.3	-2.5	-2.1	0.1	-0.3	-1.6	0.7	1.9
Systolic blood pressure, automated reading	0.4	1.2	2.7	1.4	-0.6	-0.4	-0.2	-0.7	-1.3	-1.3	-1.6	1.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.4	0.5	1.2	0.3	0.4	0.7	0.0	1.2	0.7	0.7	0.0
Angina	1.9	2.5	6.0	1.5	0.2	1.7	-1.9	-1.5	-0.5	-0.0	-1.5	2.4	2.2
Medication for hormone replacement therapy	1.3	1.5	2.9	1.5	-0.5	1.6	-0.8	-0.9	-0.9	-0.5	-1.1	1.7	1.6
Vitamin and mineral supplements	1.6	2.2	4.2	1.4	-1.6	0.8	-1.7	-2.0	-0.7	-1.4	-1.5	1.5	1.6
Supplements: Zinc	0.1	0.1	0.4	0.0	0.2	-0.3	-0.0	-0.1	-0.3	-0.2	-0.6	0.2	0.5
Medication: Co-codamol	1.5	1.8	4.7	0.8	1.1	2.2	-1.8	-1.2	0.9	1.0	-0.5	1.4	1.6
Medication: Metformin	0.1	0.2	0.5	0.7	0.6	0.2	0.4	0.5	-0.4	0.4	0.1	0.6	0.3
Diabetes (father)	0.5	0.6	3.9	0.4	0.2	2.0	-1.0	-0.6	0.1	-0.1	-0.7	-0.2	0.6
Diabetes (mother)	2.2	2.8	5.6	2.1	-2.0	-0.1	-0.3	-0.9	-2.4	-2.0	-1.6	2.1	1.4
Severe depression (siblings)	0.2	0.2	0.6	-0.0	0.1	0.7	0.1	0.2	-0.2	0.3	0.6	-0.5	-0.8
Pack years adult smoking proportion	1.3	1.9	3.0	1.4	-1.6	1.1	-1.2	-1.2	-1.7	-1.6	-1.4	1.4	1.1
Impedance of leg (right)	0.3	1.3	3.5	-0.7	1.6	1.1	0.9	0.8	1.9	1.5	1.3	-0.2	-0.1
Leg fat-free mass (left)	0.0	0.2	1.0	-0.1	0.3	-0.1	-1.0	-0.5	-0.3	-0.1	-0.4	-0.2	-0.0
Trunk fat percentage	0.5	2.2	4.5	1.8	-0.1	1.0	-1.6	-1.6	-2.1	-1.7	-1.8	1.1	0.8
Hand grip strength (right)	0.5	1.4	5.3	0.8	-2.3	-1.4	0.4	-0.4	-1.6	-1.4	-0.8	-0.8	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.7	0.9	-0.3	-0.1	0.3	0.4	0.7	0.7	0.7	-0.2
Current tobacco smoking	0.2	0.3	0.9	0.0	-1.0	-0.3	0.1	-0.2	-0.7	-0.9	-0.4	-0.4	-0.5
Average weekly fortified wine intake	0.4	0.5	1.7	0.3	1.3	-0.1	-0.0	0.3	0.8	1.1	0.4	0.9	0.5
Maternal smoking around birth	1.3	1.9	3.7	-1.8	1.7	0.7	-0.0	0.6	1.6	1.6	1.3	-1.9	-1.1
Fed-up feelings	0.4	0.8	2.7	0.8	-0.6	-0.5	-0.1	0.1	-1.6	-1.1	-0.6	1.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.8	1.1	-0.3	1.0	-0.6	-0.5	-0.2	-0.4	-0.9	1.7	2.0
Relative age voice broke	0.2	0.3	1.2	0.2	1.1	0.6	-0.2	-0.1	0.5	0.7	0.3	0.4	0.2
Taking other prescription medications	2.2	3.4	7.0	-2.1	1.7	-2.4	2.6	2.7	1.4	1.0	1.8	-0.1	-1.3
Age when periods started (menarche)	0.1	0.2	0.8	-0.4	-0.6	-0.5	0.4	0.2	-0.3	-0.9	0.2	0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.0	0.9	1.4	1.1	-1.1	-0.8	0.2	1.4	-0.2	1.3	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	7.4	1.9	-1.1	2.0	-2.7	-2.3	-1.9	-1.8	-2.3	0.7	1.4
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	8.6	2.9	-0.3	-0.5	0.2	-0.4	-2.9	-1.5	-1.8	1.8	1.5
Qualifications: CSEs or equivalent	0.1	0.2	1.0	-0.1	0.2	-0.2	-0.1	0.1	0.2	1.0	0.1	0.8	0.2
Serious illness, injury or assault to yourself	0.3	0.3	2.1	0.2	0.3	-0.7	0.2	0.1	0.1	0.1	-0.1	1.5	0.7
High blood pressure	0.3	0.8	2.8	1.4	0.0	-0.1	-0.0	-0.4	-1.7	-1.1	-0.9	0.8	0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.1	-0.8	1.8	-0.5	1.1	1.1	0.4	1.0	1.1	0.7	-0.5
Multivitamins +/- minerals	0.8	1.0	1.7	-1.0	1.3	0.6	0.7	1.1	0.9	1.1	1.1	-1.1	-1.0
Stomach or abdominal pain in last month	1.3	1.7	4.3	1.5	-0.8	0.6	-1.0	-1.1	-0.7	-0.9	-1.8	1.4	2.1
Supplements: Glucosamine	0.9	1.2	3.6	0.4	1.8	0.6	0.6	1.0	1.1	1.9	0.9	1.0	0.5
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	6.5	1.3	-2.3	0.4	-1.4	-1.7	-2.2	-2.5	-1.9	0.7	0.7
Medication: Atenolol	1.2	1.5	3.0	-1.6	0.1	-1.5	1.7	1.7	0.2	-0.0	1.0	-0.8	-1.7
Medication: Levothyroxine sodium	1.8	3.0	7.0	-1.6	0.5	-2.4	2.6	2.6	0.4	0.6	1.9	-0.8	-1.7
Sitting height	0.6	4.2	12.2	-2.5	2.4	1.5	0.1	0.7	3.5	2.7	2.2	-1.5	-0.7
Chronic bronchitis/emphysema (father)	1.0	1.1	2.7	-1.3	0.2	-1.6	0.9	1.4	1.1	1.0	1.3	-0.0	-0.7
High blood pressure (mother)	2.2	3.1	5.2	2.3	-0.6	1.2	-1.5	-1.7	-2.1	-1.9	-2.2	1.8	1.8
Body mass index (BMI)	1.1	4.7	10.4	2.4	-1.9	0.4	-2.2	-2.0	-3.2	-2.6	-2.8	1.4	1.4
Impedance of leg (left)	0.2	0.9	2.3	-0.6	1.2	1.3	0.4	0.4	1.5	1.1	1.1	-0.5	-0.3
Leg predicted mass (left)	0.0	0.2	1.0	-0.1	0.3	-0.2	-1.0	-0.5	-0.3	-0.2	-0.4	-0.2	-0.0
Trunk fat mass	0.3	1.4	2.8	1.4	-0.2	0.4	-1.4	-1.2	-1.7	-1.4	-1.5	0.8	0.7
Waist circumference	0.2	0.7	1.2	0.8	-0.5	0.1	-1.1	-0.9	-1.1	-1.1	-1.1	0.5	0.4
Number of incorrect matches in round	0.2	0.3	0.9	-0.3	0.5	-0.0	0.2	0.3	0.9	0.5	-0.2	0.4	0.9
Past tobacco smoking	0.3	0.5	1.0	0.5	0.9	1.0	-0.9	-0.6	0.4	0.4	-0.1	0.9	0.9
Alcohol usually taken with meals	0.6	1.0	2.8	-0.9	-0.2	-1.4	0.7	0.6	0.1	-0.8	0.7	-1.5	-1.7
Nervous feelings	0.1	0.2	0.5	0.5	-0.0	0.0	-0.1	-0.2	-0.7	-0.6	-0.5	0.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.8	1.2	0.0	1.7	-0.7	-0.6	-0.3	-0.2	-0.8	1.2	1.2
Hearing difficulty/problems with background noise	1.2	1.9	3.8	1.1	-1.7	-0.5	-1.2	-1.1	-1.9	-1.5	-1.9	0.9	1.3
Hair/balding pattern: Pattern 2	2.2	2.8	5.2	1.8	-1.1	1.4	-2.0	-2.3	-1.6	-1.5	-2.2	1.0	1.4
Had menopause	0.5	0.7	2.2	-0.4	1.5	-1.0	0.7	0.7	0.4	0.9	0.9	-0.4	-0.6
Had other major operations	0.2	0.3	1.3	-0.0	0.1	-0.5	-0.1	0.5	0.5	0.1	-0.0	1.1	0.8
Forced vital capacity (FVC)	0.6	2.4	9.1	-2.2	0.1	0.1	-0.3	0.1	3.0	2.4	1.5	-1.5	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.4	1.4	-1.5	1.3	-1.9	-2.0	-2.3	-2.2	-2.1	-0.5	0.4
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	10.3	1.2	-2.1	-1.2	0.5	-0.3	-3.2	-2.6	-1.7	-0.1	-0.1
Qualifications: None of the above	1.3	2.7	4.9	1.5	-1.9	-0.3	-1.8	-1.5	-1.8	-1.7	-2.2	1.3	1.6
Financial difficulties in last 2 years	1.2	1.7	3.7	0.9	-0.4	1.6	-1.9	-1.6	-1.8	-1.3	-1.3	-0.1	0.1
Mouth/teeth dental problems	0.3	0.5	1.8	0.1	-1.4	0.0	0.8	0.1	-0.3	-0.9	0.3	-0.9	-0.9
Heart attack	3.6	4.5	10.6	2.1	-0.5	3.2	-3.3	-2.7	-0.6	-0.5	-1.5	2.0	2.4
Allergy	0.3	0.7	2.4	0.4	-1.4	0.0	-0.5	-0.8	-0.6	-0.8	-0.5	-1.5	-0.5
Pain all over the body in last month	0.7	0.7	3.6	0.1	-1.9	-0.3	-0.5	-0.5	-0.8	-1.1	-0.9	-0.2	-0.0
Diabetes (self-reported)	0.3	0.5	1.5	0.2	0.4	-0.8	0.9	1.2	-1.0	0.2	0.3	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.9	0.8	-0.1	1.2	-0.1	-0.5	-1.2	-0.8	-0.7	1.4	0.5
Medication: Ramipril	0.2	0.2	0.5	0.0	0.6	0.2	0.5	0.7	0.7	0.5	0.5	0.4	0.3
Medication: Simvastatin	0.2	0.4	0.6	-0.5	0.5	-0.7	0.7	0.7	0.5	0.5	0.8	-0.2	-0.6
Fluid intelligence score	1.2	2.5	10.6	-2.1	0.4	-0.2	-0.2	-0.2	1.1	0.6	1.4	-3.2	-2.5
Illnesses of siblings	1.8	2.5	4.0	-1.6	1.5	-1.4	1.7	2.0	1.6	1.8	1.7	-1.0	-1.2
Neuroticism score	0.8	1.7	4.5	1.7	-0.4	0.8	-0.8	-0.6	-1.6	-0.8	-1.4	2.1	1.5
Weight	0.1	0.3	1.2	0.4	0.2	-0.1	-1.1	-0.7	-0.6	-0.4	-0.7	0.1	0.3
Impedance of arm (right)	0.6	2.9	11.2	-1.0	3.3	1.3	0.8	0.6	1.9	2.1	1.8	-1.1	-1.1
Arm fat percentage (right)	1.1	4.4	10.9	2.5	-1.2	0.9	-2.0	-2.1	-3.3	-2.6	-2.6	1.2	1.1
Trunk fat-free mass	0.1	0.3	0.8	-0.9	0.2	-0.9	-0.6	-0.0	0.8	0.6	0.2	-0.5	-0.0
Hip circumference	0.2	1.0	2.9	1.2	-0.3	-0.1	-1.1	-0.8	-1.7	-1.2	-1.3	0.6	0.5
Time employed in main current job	0.1	0.2	0.8	-0.0	0.5	-0.2	0.4	0.1	0.4	0.3	0.1	-0.9	-0.3
Alcohol intake versus 10 years previously	0.4	0.6	2.4	0.7	-0.1	1.5	-1.2	-0.7	-0.7	-0.1	-0.7	0.3	0.7
Father’s age at death	0.5	0.7	2.0	-0.1	1.2	-1.4	1.1	1.1	0.2	0.4	1.0	0.3	-0.5
Worrier / anxious feelings	0.5	1.0	2.1	1.4	-0.8	0.7	-0.5	-0.5	-1.4	-1.1	-1.4	0.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.3	0.4	-0.9	0.2	0.1	0.4	-0.7	-0.6	-0.4	1.1	0.3
Falls in the last year	0.5	0.7	2.6	1.1	-0.1	0.2	-0.1	-0.2	-0.5	-0.3	-1.0	1.6	1.4
Hair/balding pattern: Pattern 3	0.6	0.9	4.3	0.1	-0.9	-2.1	1.5	1.3	-0.4	-0.2	0.0	-0.2	0.1
Number of live births	1.4	2.0	4.5	1.1	-2.1	1.3	-1.9	-1.5	-0.2	-0.9	-1.6	0.7	1.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.3	-1.3	0.2	1.2	-0.9	-0.5	2.1	1.7	0.6	-1.4	0.2
Pulse rate	0.2	0.3	0.7	0.0	0.3	-0.9	0.8	0.7	0.6	0.7	0.1	0.5	0.5
Happiness	0.6	0.7	2.1	0.9	-0.9	-0.5	0.6	0.2	-1.4	-1.1	-0.9	0.7	0.6
Noisy workplace	0.6	0.7	1.1	1.0	-1.0	-0.1	-0.9	-1.1	-1.0	-0.9	-1.1	-0.2	0.2
Qualifications: A levels/AS levels or equivalent	5.0	11.0	20.5	-4.1	2.2	-2.3	3.4	3.0	2.6	2.1	4.0	-3.8	-4.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.8	-1.3	0.3	-0.8	0.9	0.9	0.3	0.2	1.0	-2.2	-2.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	-1.0	0.9	-0.4	-0.2	-0.0	1.3	1.1	-0.4	-0.6	0.4
Asthma	0.3	0.5	3.2	0.8	0.1	0.1	0.5	0.2	-0.6	-0.6	-0.3	1.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.5	1.2	0.0	2.1	-1.5	-1.3	-0.1	0.4	-0.9	0.8	1.6
Medication: Cholesterol lowering	0.6	0.9	1.8	-0.4	1.0	-1.4	1.3	1.2	0.5	0.9	1.3	0.3	-0.6
Depression (self-reported)	0.5	0.6	1.5	0.4	0.4	-0.8	1.2	1.0	-0.8	-0.6	-0.1	1.2	0.2
Medication: Lansoprazole	2.3	2.6	5.1	1.7	-1.6	0.9	-0.5	-0.7	-1.7	-1.8	-2.0	2.2	2.0
Prospective memory result	0.6	0.8	3.4	1.0	0.2	-0.0	0.1	0.5	0.5	0.7	-0.2	1.9	1.5
Lung cancer (father)	2.3	2.7	5.5	-2.4	1.0	-1.5	0.9	1.4	1.8	1.7	1.9	-1.4	-1.8
Illnesses of mother	0.8	1.0	2.3	-1.2	-0.1	-0.7	1.0	1.3	1.5	1.5	1.0	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.5	-1.5	0.4	0.5	-0.5	-0.2	1.9	1.6	0.8	-1.4	-0.3
Pulse wave Arterial Stiffness index	1.0	1.1	1.7	-1.3	0.9	-1.0	1.3	1.2	1.3	1.0	1.3	0.5	-0.4
Impedance of arm (left)	0.8	3.8	11.4	-1.5	3.4	0.2	1.7	1.4	2.2	2.3	2.4	-1.3	-1.5
Arm fat mass (right)	0.8	3.1	6.5	2.0	-0.9	0.7	-2.0	-1.9	-2.5	-2.0	-2.3	1.0	1.2
Trunk predicted mass	0.1	0.4	0.8	-0.9	0.2	-0.9	-0.6	-0.0	0.9	0.7	0.2	-0.6	-0.0
Standing height	1.2	12.0	27.7	-4.0	4.4	-0.8	1.7	2.4	5.3	4.5	4.0	-2.5	-2.0
Length of working week for main job	1.3	1.5	3.1	-1.2	1.7	0.8	-0.2	0.1	1.8	1.6	1.3	-1.3	-0.8
Exposure to tobacco smoke at home	0.9	1.1	3.1	-0.9	1.5	-0.7	0.3	0.6	1.4	1.8	1.1	-0.2	-0.4
Breastfed as a baby	1.5	1.9	5.0	-1.2	2.1	0.6	-0.0	0.3	2.0	2.2	1.8	-0.5	-0.6
Tense / ‘highly strung’	1.0	1.7	3.4	1.5	-0.2	1.1	-1.7	-1.3	-1.6	-0.8	-1.9	0.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.2	1.2	-1.0	0.2	-0.2	-0.3	-1.5	-0.9	-1.0	1.3	0.8
Hair/balding pattern: Pattern 4	1.4	3.4	6.9	-1.3	2.6	-2.1	2.1	2.4	0.6	1.2	2.1	-0.3	-2.1
Birth weight of first child	0.9	1.7	5.2	1.3	-2.3	-0.1	-0.5	-0.8	-1.3	-1.8	-1.8	-0.3	0.9
Peak expiratory flow (PEF)	0.7	1.7	9.8	0.3	0.1	3.1	-1.7	-1.5	0.5	0.5	-0.6	-0.3	1.0
Pulse wave reflection index	0.9	1.1	2.8	-1.5	0.6	-0.1	0.9	1.1	0.9	0.9	1.7	-0.7	-1.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	0.4	0.4	-0.3	-0.1	-0.3	-1.1	-0.5	-0.9	0.1	0.4
Loud music exposure frequency	2.0	2.2	5.1	1.8	-1.2	-0.1	-0.6	-0.8	-2.3	-1.9	-2.1	1.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.1	-0.3	1.0	-0.6	2.0	1.4	0.3	0.6	1.1	-0.5	-1.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.0	1.6	-0.4	0.7	-0.6	-0.4	-2.0	-1.2	-1.0	1.4	0.8
Blood clot in the leg (DVT)	1.3	1.7	4.7	1.0	-1.1	1.4	-1.3	-1.2	0.7	-0.3	-1.3	1.6	2.2
Medication: Paracetamol	0.8	1.4	2.9	0.9	-0.8	1.7	-1.4	-1.3	-0.3	-0.4	-0.9	1.6	1.6
Headache pain in last month	0.2	0.4	2.3	0.1	-0.0	-0.4	0.1	-0.2	-1.5	-0.9	0.0	-0.2	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.7	-0.0	-1.3	0.7	-1.0	-1.0	0.0	-0.5	-1.2	-0.0	0.9
Glaucoma (self-reported)	1.6	1.9	8.5	-0.4	2.9	0.6	-0.4	0.4	1.5	2.3	1.3	0.0	-0.6
Gout (self-reported)	0.2	0.3	0.6	-0.2	-0.3	-0.8	0.8	0.6	-0.5	-0.6	0.4	0.2	-0.7
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	9.7	-1.3	0.8	-3.1	3.0	3.0	-0.3	0.1	1.8	-0.7	-1.9
Medication: Amlodipine	0.1	0.2	0.6	-0.5	-0.2	-0.3	0.7	0.7	0.4	-0.2	0.2	-0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.6	0.1	-0.3	0.0	0.3	-0.2	-0.6	-1.3	-0.1	1.0	-0.2
Birth weight	0.1	0.3	0.9	-0.9	-0.0	-0.3	-0.4	0.5	1.0	0.6	0.1	-0.7	0.2
Chronic bronchitis/emphysema (mother)	1.3	1.6	3.1	-1.4	1.6	-1.0	0.6	1.1	1.8	1.6	1.7	0.3	-0.6
High blood pressure (siblings)	1.9	2.7	5.6	2.4	-1.2	0.6	-1.2	-1.5	-1.7	-1.6	-1.7	1.9	1.9
Forced vital capacity (FVC), Best measure	0.6	2.1	7.1	-2.3	0.0	-0.2	-0.3	-0.0	2.7	2.0	1.4	-1.5	-0.5
Body fat percentage	0.9	3.6	8.1	2.3	-1.1	0.8	-1.7	-1.8	-2.8	-2.5	-2.4	1.2	1.0
Leg fat percentage (right)	1.4	5.3	11.1	2.8	-2.3	0.7	-1.6	-1.9	-3.3	-3.1	-2.8	1.4	1.4
Arm fat-free mass (right)	0.1	0.3	1.3	-0.3	-0.5	-0.3	-1.2	-0.5	0.2	-0.2	-0.5	-0.1	0.4
Exposure to tobacco smoke outside home	1.4	1.9	3.7	1.6	-0.6	0.6	-1.9	-1.7	-1.3	-0.5	-1.8	1.2	1.6
Comparative body size at age 10	0.4	1.2	8.2	-0.4	-0.4	-0.1	-0.8	-0.5	-0.7	-0.5	-0.2	-2.9	-1.5
Number of full brothers	0.2	0.3	0.9	0.9	-0.2	-0.0	-0.2	-0.1	-0.6	-0.1	-1.0	0.2	0.8
Worry too long after embarrassment	0.0	0.1	0.2	0.1	-0.2	0.4	-0.0	-0.1	-0.5	-0.4	-0.3	0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.1	0.2	-0.1	0.0	0.1	-0.2	-0.1	0.0	0.3	-0.1
Wheeze or whistling in the chest in last year	1.2	2.1	4.5	1.6	-0.3	2.1	-1.6	-1.3	-0.4	-0.7	-1.5	1.8	1.9
Number of children fathered	0.4	0.4	0.8	0.7	-0.9	0.5	-0.5	-0.5	-0.2	-0.8	-0.9	-0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	5.9	0.9	0.3	1.7	-1.3	-0.7	0.8	0.8	-0.8	2.0	2.4
Age at first live birth	2.4	4.2	13.2	-2.8	0.8	-0.4	1.2	1.0	1.5	1.2	2.2	-3.6	-3.0
Pulse wave peak to peak time	0.6	0.7	1.4	0.9	-0.5	0.9	-1.2	-1.0	-0.8	-0.6	-0.9	-0.8	0.1
Health satisfaction	0.7	0.9	2.2	0.6	-1.5	0.3	-0.0	-0.6	-1.1	-1.2	-0.9	1.2	0.7
Shortness of breath walking on level ground	1.0	1.1	4.3	0.7	0.4	-0.7	1.7	1.4	0.1	0.7	0.8	2.1	0.5
Qualifications: College or University degree	3.1	9.7	14.0	-3.6	2.4	-2.5	3.7	3.4	2.9	2.3	3.7	-2.8	-3.4
Eye problems/disorders: None of the above	0.3	0.4	1.0	-0.3	-1.0	-0.9	0.8	0.4	-0.1	-0.5	0.3	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.8	1.1	-1.1	-0.9	-0.5	-0.5	-1.4	-1.1	-1.7	1.2	1.2
Emphysema/chronic bronchitis	0.4	0.4	2.1	-0.2	-0.1	-0.9	1.4	1.0	0.2	0.1	0.1	0.5	0.2
Medication for pain relief, constipation, heartburn	2.0	3.4	8.0	-1.9	0.7	-1.7	2.2	1.9	0.9	0.4	2.0	-2.4	-2.8
Neck or shoulder pain in last month	1.5	2.2	3.9	1.5	0.4	2.0	-1.9	-1.5	-1.2	-0.5	-1.6	1.7	1.5
Medication: Blood pressure	0.3	0.5	2.1	1.1	1.5	0.3	0.3	0.2	-0.8	0.3	0.4	0.9	-0.1
Angina (self-reported)	1.8	2.3	5.3	1.5	-0.1	1.6	-1.9	-1.5	-0.6	-0.3	-1.5	2.3	2.1
Migraine (self-reported)	0.9	1.2	2.9	-0.9	0.9	-0.8	1.5	1.0	0.1	0.5	1.4	-0.9	-1.7
Medication: Ibuprofen	0.4	0.4	2.2	0.5	-0.1	1.5	-0.5	-0.5	0.3	0.5	-0.2	0.3	0.8
Medication: Allopurinol	0.2	0.3	1.1	-0.8	0.1	0.1	-0.2	-0.2	0.1	-0.6	0.3	-0.9	-1.0
Medication: Omeprazole	0.1	0.1	0.6	-0.8	-0.3	-0.4	-0.5	0.1	0.3	-0.1	0.1	0.3	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	1.0	-0.9	0.3	-0.3	-0.2	-0.4	0.1	-0.5	-0.1	-1.0	-0.4
Mean time to correctly identify matches	0.6	1.0	2.6	0.7	-1.0	-1.3	0.3	-0.4	-1.6	-1.6	-1.4	0.1	0.5
Heart disease (mother)	0.7	0.9	2.1	1.2	-0.8	0.1	-0.6	-0.6	-1.1	-1.4	-1.4	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.8	0.8	0.5	2.0	-1.4	-1.2	-0.4	-0.4	-0.8	0.6	0.9
Whole body fat mass	0.6	2.6	5.8	1.8	-0.8	0.5	-1.7	-1.6	-2.4	-2.1	-2.1	0.9	0.9
Leg fat mass (right)	0.8	3.2	6.2	2.1	-1.4	0.6	-1.9	-1.7	-2.5	-2.1	-2.2	1.1	1.2
Arm predicted mass (right)	0.1	0.3	1.5	-0.1	-0.7	-0.3	-1.2	-0.6	0.0	-0.3	-0.7	0.1	0.6
Pulse rate, automated reading	0.0	0.1	0.2	0.2	-0.3	-0.3	0.4	0.2	-0.1	-0.4	-0.3	-0.3	0.2
Alcohol intake frequency.	0.7	1.5	3.1	1.6	-0.1	0.9	-1.2	-0.9	-1.3	-0.2	-1.4	1.8	1.6
Comparative height size at age 10	1.0	5.8	15.0	-2.6	3.2	-1.2	0.7	1.5	3.9	3.4	2.4	-1.8	-0.8
Number of full sisters	2.6	3.1	6.9	1.2	-1.4	2.4	-2.5	-2.6	-0.8	-0.9	-2.0	0.6	1.7
Suffer from ‘nerves’	0.9	1.4	3.5	1.0	0.5	1.9	-1.4	-1.3	-0.6	-0.6	-1.2	1.5	1.3
Overall health rating	1.2	2.7	9.8	1.6	-1.0	0.8	-0.6	-0.7	-1.3	-1.2	-1.8	3.1	2.3
Chest pain or discomfort	2.0	2.9	8.3	2.2	-0.9	0.8	-1.1	-1.1	-1.5	-1.0	-2.0	2.9	2.4
Had major operations	0.3	0.3	1.0	0.8	-0.2	0.6	0.2	-0.3	-1.0	-0.5	-0.2	0.8	-0.0
Age at last live birth	2.2	3.2	7.5	-2.4	0.4	-1.3	1.9	1.6	1.3	1.1	1.7	-2.7	-2.2
Family relationship satisfaction	0.5	0.6	1.6	0.9	0.0	0.6	-0.5	-0.7	-0.5	-0.1	-0.9	1.3	1.1
Leg pain on walking	1.8	2.3	5.3	1.6	-0.4	1.7	-1.6	-1.6	-0.1	-0.3	-1.2	2.3	2.3
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	5.2	2.0	-0.5	2.3	-2.3	-2.1	-1.1	-1.0	-1.9	1.7	1.9
Commuting to job workplace: Car/motor vehicle	1.4	1.5	4.5	0.9	-1.5	-1.2	0.8	0.1	-2.1	-2.1	-0.9	-0.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.0	-0.7	-0.2	-0.5	-0.7	0.0	-0.3	-0.5	0.5	0.6
Medication: Aspirin	0.4	0.5	1.8	-0.5	1.4	-0.7	0.2	0.5	0.7	1.1	0.5	-0.4	-0.1
Supplements: Vitamin C	0.4	0.4	2.5	-0.3	0.1	-0.8	0.4	0.3	-0.4	0.1	-0.3	-1.6	-0.8
Knee pain experienced in last month	1.4	2.2	4.4	1.7	0.5	1.5	-2.1	-1.6	-0.5	0.3	-1.3	1.8	2.1
Hypertension (Self-reported)	0.2	0.4	1.5	1.0	0.8	-0.6	0.6	0.2	-1.2	-0.4	-0.3	0.4	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.6	1.3	-2.2	-0.2	-0.4	-0.3	-1.8	-2.4	-1.8	1.6	1.2
Illnesses of father: Heart disease	1.3	1.8	3.8	2.0	-0.2	1.6	-1.1	-1.0	-0.8	-0.6	-1.6	1.4	1.9
Illnesses of siblings: Diabetes	0.3	0.3	1.7	-1.3	-0.8	0.3	-0.0	0.0	0.8	0.0	0.4	-0.3	-0.3
Smoking status: Previous	0.3	0.5	1.2	-1.0	-0.2	-0.5	0.6	0.6	0.4	0.3	0.6	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.2	-1.3	0.4	1.0	-1.8	-1.3	0.9	0.6	-0.0	-1.3	-0.2
Whole body fat-free mass	0.0	0.2	0.8	-0.5	0.1	-0.5	-0.9	-0.3	0.4	0.3	-0.1	-0.3	0.1
Leg fat-free mass (right)	0.0	0.2	1.4	-0.2	0.1	-0.1	-1.2	-0.6	-0.3	-0.2	-0.4	-0.3	-0.1
Arm fat percentage (left)	1.0	3.9	10.6	2.4	-1.2	0.4	-1.7	-1.8	-3.3	-2.6	-2.5	1.1	1.0
Average weekly red wine intake	0.5	0.7	3.2	-0.6	0.5	-0.6	0.4	0.3	-0.3	-0.9	0.0	-1.8	-1.3
Handedness (chirality/laterality): Left-handed	3.4	4.1	6.3	1.4	-2.1	2.5	-2.3	-2.5	-0.8	-1.7	-2.2	1.7	2.2
Mood swings	0.7	1.2	3.7	1.6	-0.4	0.1	-0.3	-0.1	-1.4	-0.6	-1.0	1.9	1.3
Loneliness, isolation	0.9	1.3	4.5	1.3	0.2	1.0	-0.3	-0.3	-0.7	-0.2	-1.0	2.1	1.9
Long-standing illness, disability or infirmity	0.4	0.6	2.2	-0.3	1.5	-0.6	1.0	1.2	0.1	0.5	0.5	0.9	0.1
Ever had bowel cancer screening	0.8	0.9	1.4	1.0	-0.7	0.7	-0.9	-1.2	-0.6	-1.0	-1.1	1.2	1.1
Diabetes diagnosed by doctor	0.3	0.4	1.6	0.2	0.6	-0.8	1.0	1.3	-0.7	0.4	0.2	-0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.3	-0.8	0.4	-0.5	-0.4	-0.1	-0.6	-0.3	-0.4	-0.2
Friendships satisfaction	0.5	0.6	1.4	0.3	-0.3	0.4	-0.8	-0.9	-1.2	-0.6	-0.5	-1.2	-0.7
Qualifications: nursing, teaching	1.2	1.9	7.0	-1.3	1.4	-0.5	0.9	0.5	0.8	0.8	1.2	-2.6	-1.9
Commuting to job workplace: Walk	2.5	2.7	4.2	-2.0	1.7	-1.0	1.1	1.4	1.7	2.0	1.9	-1.3	-1.7
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.4	-0.1	0.6	-0.8	-0.4	0.3	0.2	-0.2	0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.5	-0.5	1.2	-1.9	0.9	1.4	0.3	1.0	0.7	0.5	-0.0
Medication for cholesterol	0.2	0.4	1.2	-0.2	0.6	-0.3	0.1	0.5	1.1	1.1	0.6	0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.6	1.0	0.3	2.1	-2.1	-1.7	0.2	0.3	-0.9	2.0	2.0
Back pain experienced in last month	2.4	3.5	6.0	2.3	-1.0	2.4	-2.1	-1.9	-1.5	-1.3	-2.0	1.9	1.9
Mineral and other dietary supplements	0.8	1.1	2.1	0.8	-1.3	0.4	-1.4	-1.4	-1.0	-1.1	-1.0	0.8	0.6
Breast cancer (self-reported)	1.5	1.8	4.8	1.0	0.3	2.1	-2.2	-1.6	0.2	-0.0	-0.8	1.3	1.4
Asthma (self-reported)	0.3	0.5	3.9	0.7	0.2	0.1	0.6	0.4	-0.2	-0.3	-0.0	2.0	0.6
Osteoporosis (self-reported)	3.0	3.7	10.8	-2.0	0.7	-3.3	2.5	2.2	1.6	1.2	1.7	-1.2	-1.6
Osteoarthritis (self-reported)	0.8	1.1	3.5	-0.8	1.7	0.1	-0.4	0.4	1.9	1.8	0.6	0.2	0.3
Medication: Aspirin	0.2	0.2	1.3	0.0	1.1	-0.2	-0.0	0.3	0.4	0.8	0.2	0.1	0.3
Medication: Gliclazide	0.4	0.4	1.4	0.8	1.2	0.7	0.6	0.5	-0.1	0.7	0.4	0.7	0.3
Illnesses of father: None of the above (group 1)	1.8	2.2	7.1	-1.6	0.9	-1.2	1.4	1.2	-0.0	0.3	1.4	-2.1	-2.7
Smoking status: Current	0.3	0.5	1.8	0.3	-1.4	-0.3	-0.0	-0.4	-1.0	-1.2	-0.8	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.2	-1.5	0.6	0.5	-0.4	-0.1	1.8	1.6	0.6	-1.4	-0.1
Whole body water mass	0.0	0.2	0.9	-0.5	-0.0	-0.4	-1.0	-0.4	0.3	0.2	-0.2	-0.2	0.2
Leg predicted mass (right)	0.0	0.2	1.3	-0.2	0.1	-0.1	-1.2	-0.6	-0.2	-0.1	-0.4	-0.4	-0.1
Arm fat mass (left)	0.7	3.0	6.4	1.9	-1.1	0.3	-1.8	-1.7	-2.5	-2.1	-2.3	1.0	1.2
Number of self-reported non-cancer illnesses	1.3	2.2	6.0	-0.9	1.4	-2.4	2.3	2.2	0.1	0.5	1.2	0.8	-0.9
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-1.1	0.5	-0.0	0.6	0.4	0.8	0.4	0.7	-0.9	-0.9
Miserableness	0.4	0.7	3.3	1.2	-0.6	-0.5	0.3	0.2	-1.8	-1.0	-0.6	0.4	-0.0
Guilty feelings	0.9	1.3	2.6	0.9	-1.6	1.2	-1.0	-0.9	-0.2	-0.6	-1.1	1.6	1.5
Wears glasses or contact lenses	0.6	0.7	3.2	-0.2	-0.5	-1.0	1.8	1.2	0.1	-0.4	0.5	0.5	-0.1
Ever taken oral contraceptive pill	4.3	4.8	8.9	-2.2	1.0	-2.0	3.0	2.6	1.5	1.4	2.6	-1.9	-2.7
Hearing aid user	0.5	0.6	3.5	-0.1	1.9	0.3	-0.7	0.2	0.7	0.8	0.4	0.8	0.5
Mother’s age at death	0.2	0.2	0.9	-0.0	0.2	-0.2	0.2	-0.0	-1.0	-0.7	0.3	-0.4	-0.8
Financial situation satisfaction	1.1	1.4	3.4	0.4	-1.8	0.4	-0.9	-0.8	-1.7	-1.8	-1.4	-0.6	-0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.3	-0.2	-0.7	0.2	0.6	-0.1	0.0	0.2	0.6	-0.0
Commuting to job workplace: Public transport	4.2	5.0	8.8	-3.0	1.6	-0.3	2.1	2.0	2.5	2.4	2.8	-2.2	-2.4
Eye problems/disorders: Glaucoma	1.1	1.3	7.1	-0.0	2.7	0.7	-0.5	0.1	0.9	1.6	0.9	-0.1	-0.7
Medication: Blood pressure	0.3	0.5	2.2	0.2	-0.5	-0.2	-0.0	-0.3	-1.2	-1.5	-0.9	-0.6	-0.3
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.2	0.9	-1.1	1.6	-1.5	-1.5	-1.8	-2.0	-1.3	0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.9	-1.1	1.2	0.2	0.2	0.7	1.1	1.2	1.0	-1.4	-0.7
High cholesterol (Self-reported)	0.3	0.5	1.4	-0.2	1.2	-0.6	1.0	0.7	-0.2	0.0	0.5	-0.5	-0.8
Medication: Bendroflumethiazide	1.5	2.2	6.2	1.2	-1.3	0.4	-1.1	-1.5	-2.5	-2.5	-1.8	-0.3	-0.1
Medication: Paracetamol	0.2	0.3	1.0	0.2	-0.5	1.0	-0.3	-0.3	-0.1	-0.2	-0.1	0.9	0.6
Medication: Lisinopril	3.2	4.1	6.1	-2.0	2.2	-1.8	2.5	2.4	1.7	1.9	2.3	-1.1	-2.0
Medication: Atorvastatin	0.1	0.1	0.3	-0.1	0.5	-0.2	0.2	0.3	0.3	0.1	0.3	-0.1	-0.3
Illnesses of father: High blood pressure	1.8	2.2	4.7	1.9	-1.4	0.7	-1.0	-1.2	-1.1	-1.2	-1.5	2.2	1.9
Alcohol drinker status: Never	0.2	0.3	1.3	-0.0	0.5	0.2	-0.3	-0.0	0.8	1.1	0.3	-0.3	0.4
Ever smoked	0.3	0.5	1.2	-0.3	-0.7	-1.0	1.1	0.9	-0.7	-0.5	0.1	-0.5	-0.9
Basal metabolic rate	0.0	0.2	1.3	-0.1	-0.0	-0.2	-1.1	-0.6	-0.0	-0.0	-0.4	-0.0	0.3
Leg fat percentage (left)	1.5	5.4	12.3	2.7	-2.5	0.6	-1.8	-2.0	-3.5	-3.3	-2.8	1.2	1.1
Arm fat-free mass (left)	0.1	0.4	2.0	0.1	-0.6	0.2	-1.4	-0.9	0.0	-0.2	-0.7	0.4	0.8
Number of operations (self-reported)	0.3	0.5	1.3	0.4	0.1	0.9	-1.1	-0.8	0.2	0.2	-0.3	1.1	0.9
Average weekly beer plus cider intake	0.7	1.0	2.2	1.4	-1.0	0.6	-0.9	-0.8	-0.8	-0.0	-1.3	0.7	1.5
Irritability	0.1	0.2	1.0	0.4	-0.3	-0.4	-0.2	0.3	-0.7	-0.3	-0.1	1.0	0.4
Risk taking	0.3	0.5	1.7	0.9	-0.6	0.6	-0.3	-0.4	-0.2	-0.2	-0.7	1.0	1.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.2	0.7	0.3	-0.3	-0.4	0.6	0.4	0.1	0.7	0.6
Fractured/broken bones in last 5 years	0.5	0.6	1.4	-1.2	1.0	-0.5	0.5	0.5	1.0	1.0	0.7	-0.3	-0.4
Age started oral contraceptive pill	4.9	6.1	12.2	-3.5	2.0	-2.6	2.2	2.0	2.7	1.8	2.8	-2.1	-2.6
Diastolic blood pressure, automated reading	0.5	1.6	3.6	1.9	-0.9	-0.1	-0.7	-0.9	-1.1	-1.1	-1.5	1.5	1.7
Ever depressed for a whole week	0.9	1.1	2.6	0.9	-1.1	-0.4	-0.2	-0.6	-1.6	-1.6	-1.1	1.1	0.6
Unable to work because of sickness or disability	0.9	1.2	2.5	0.9	-0.7	1.2	-0.8	-0.8	-1.0	-1.6	-1.4	1.3	0.9
Commuting to job workplace: Cycle	1.1	1.4	2.5	-1.3	1.5	-0.1	0.7	0.8	1.4	1.6	1.5	-0.8	-1.1
Myopia	0.3	0.4	1.3	-0.8	-1.1	0.6	-0.2	-0.4	0.7	-0.1	0.4	-0.5	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.8	-1.2	-0.3	-0.2	0.3	0.5	1.4	0.8	0.8	-0.8	-0.5
Cholesterol lowering medication	0.2	0.3	1.1	-0.1	0.4	0.8	-0.3	-0.3	-0.0	-0.0	0.2	-1.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	-0.6	-1.0	-0.3	-0.5	0.0	0.3	-0.2	-0.3	0.8	0.5
Pain experienced in last month	2.5	4.1	8.8	-3.0	0.0	-2.4	1.8	1.7	2.0	0.7	1.9	-2.7	-2.3
Supplements: Calcium	6.8	7.5	12.1	-3.4	3.0	-1.4	1.9	1.9	3.4	3.5	3.0	-2.8	-2.1
Basal cell carcinoma (self-reported)	3.1	3.7	11.2	-1.6	3.4	-0.6	1.4	1.8	1.8	2.1	2.4	-1.1	-1.9
Heart attack/myocardial infarction (self-reported)	3.6	4.6	10.7	2.2	-0.7	3.1	-3.3	-2.8	-0.9	-0.7	-1.6	1.9	2.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.1	0.8	-0.9	1.1	-1.0	-1.0	0.8	-0.2	-1.1	1.5	2.0
Heart disease (siblings)	0.6	0.8	3.0	0.5	0.2	0.9	-1.7	-1.0	-0.4	-0.2	-1.2	0.5	0.9
Alcohol drinker status: Previous	1.6	1.8	4.5	1.4	-0.7	-0.0	-1.0	-1.2	-1.7	-1.0	-2.1	1.5	1.5
Pack years of smoking	1.1	1.5	2.5	1.2	-1.6	0.7	-0.8	-1.0	-1.5	-1.5	-1.3	1.5	1.1
Impedance of whole body	0.6	2.9	8.2	-1.2	2.9	1.0	1.2	1.1	2.4	2.2	2.1	-0.7	-0.9
Leg fat mass (left)	0.9	3.4	6.8	2.0	-1.4	0.7	-2.1	-1.9	-2.6	-2.2	-2.3	0.9	1.1
Arm predicted mass (left)	0.1	0.5	2.4	0.2	-0.5	0.2	-1.6	-0.9	-0.0	-0.3	-0.8	0.4	0.9