Hub : Genes

NAT8B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0173 0.0085 0.00150 0.000 0.001 -0.001 0.002 -0.001 3.4e-01 1.1e-01 5.9e-01 0.057 7.5e-01
2 TCGA Breast Invasive Carcinoma 0.0407 0.0245 0.00031 0.026 0.021 0.021 NA 0.023 3.2e-06 2.7e-05 2.9e-05 NA 1.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 1.6 -1.2 -1.1
Bipolar Disorder or Schizophrenia 0.5 1.3 1.6 -1.3 -1.0
Depressed Affect (Nagel 2018) 0.3 0.7 1.4 1.2 0.0
Depression (Nagel 2018) 0.2 0.3 0.6 0.8 -0.2
Intelligence (Savage-Jansen 2018) 2.5 7.7 13.9 -3.7 1.2
Neuroticism (Nagel 2018) 0.0 0.1 0.2 0.5 -0.1
Schizophrenia (2018) 0.1 0.2 0.3 -0.5 -0.3
Schizophrenia vs Biploar Disorder 0.9 1.2 2.1 1.4 0.6
Worry (Nagel 2018) 0.3 0.7 1.4 -0.0 -1.2
Alzheimer’s Disease (in mother) 3.2 3.8 5.4 -2.3 1.4
Alzheimer’s Disease (in father) 0.5 0.6 1.1 -0.2 -1.1
Alzheimer’s Disease (including proxy) 1.2 1.7 2.2 -1.5 1.1
Crohns Disease (2017) 0.2 0.4 0.7 -0.8 -0.4
Irritable Bowel Disease (IBD) 0.3 0.7 0.9 -0.9 0.7
Ulcerative Colitis (UC) 0.3 0.5 1.0 -0.2 1.0
Major Depression (MDD) 1.0 1.2 1.9 0.8 -1.4
Reaction Time 0.1 0.2 0.2 0.5 0.4
Verbal and Numeric Reasoning (VNR) 0.9 2.2 4.4 -2.1 -0.2
Breast Cancer 0.0 0.0 0.0 0.2 -0.1
Ovarian Cancer 0.2 0.3 0.4 0.4 -0.7
Prostate Cancer 0.4 0.6 0.8 0.9 -0.5
Age at First Birth 0.1 0.1 0.2 -0.4 -0.1
Bipolar Disorder (2011) 0.7 0.7 1.4 -1.2 0.1
Body Mass Index (BMI) (2010) 0.4 0.5 1.0 -1.0 0.2
Coronary Artery Disease (CAD) 1.7 2.0 4.0 2.0 -0.2
Crohns Disease (2012) 0.3 0.6 1.1 0.1 -1.1
Mean Putamen Volume 0.1 0.1 0.2 0.2 -0.4
Fasting Glucose 1.7 2.0 2.2 -1.5 -1.3
HbA1C 0.8 0.9 1.9 0.0 -1.4
HDL Cholesterol 0.4 0.7 1.1 1.1 0.5
LDL Cholesterol 0.8 1.3 2.1 -1.4 -0.7
Lupus 0.1 0.2 0.3 -0.6 0.2
Neuroticism (2016) 0.1 0.2 0.3 0.2 -0.6
Primary Biliary Cirrhosis 3.2 4.5 4.8 -2.1 2.2
Rheumatoid Arthritis 0.4 0.6 0.9 0.9 0.5
Schizophrenia (2014) 0.3 0.7 1.3 -0.4 -1.1
Triglycerides 0.1 0.1 0.2 0.2 -0.4
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.4 0.3 -1.5
Ulcerative Colitis 2.3 3.4 5.8 -1.0 2.4
Blood Eosinophil Count 0.2 1.6 3.0 0.5 1.7
Blood Platelet Count 1.6 18.9 35.6 -6.0 1.4
Blood Red Count 0.2 1.6 1.8 1.3 -1.2
Blood White Count 0.3 2.2 2.6 1.6 -1.3
Heel T-Score 0.2 1.8 2.8 0.8 -1.7
BMI 0.2 0.9 1.4 1.2 -0.7
Height 0.2 4.2 7.1 2.7 -1.1
Waist Hip Ratio (WHR) 0.1 0.2 0.5 -0.1 -0.7
Systolic Blood Pressure 1.5 7.4 8.5 2.9 -2.5
Smoking Status 0.8 1.9 3.1 1.8 -0.9
Allergy or Eczema 0.1 0.3 0.3 0.5 0.6
Cardiovascular Disease 0.1 0.4 0.8 0.9 0.3
Hypothyroidism (self reported) 0.2 0.4 0.5 0.7 -0.6
Respiratory disease 0.8 1.8 3.5 1.9 0.3
Type 2 Diabetes (T2D) (2018) 1.8 3.4 6.2 0.8 -2.5
Lung FEV1/FVC ratio 0.0 0.0 0.0 0.0 -0.2
Lung FVC 0.3 1.7 1.9 1.2 -1.4
Neuroticism 0.0 0.0 0.0 -0.2 0.2
Chronotype (morning person) 0.9 2.0 3.6 0.6 -1.9
Hair Pigment 0.1 1.8 2.9 1.7 -0.8
Tanning 0.0 0.6 0.7 0.7 -0.8
Hand grip strength (left) 0.6 1.5 1.8 1.3 -1.1
Number of treatments/medications taken 2.3 4.2 5.3 2.3 -1.8
Average weekly spirits intake 1.1 1.3 2.0 0.8 -1.4
Sensitivity / hurt feelings 0.4 0.6 0.8 -0.9 0.6
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.6 -0.4 0.8
Hearing difficulty/problems: Yes 0.7 1.1 1.5 1.2 -0.8
Relative age of first facial hair 0.8 1.6 2.3 -0.9 1.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.3 -0.5 0.5
Ever used hormone-replacement therapy (HRT) 2.6 3.3 5.9 2.4 -0.9
Ever had hysterectomy (womb removed) 0.5 0.6 1.1 0.3 1.0
Systolic blood pressure, automated reading 1.5 4.2 6.3 2.5 -1.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.1 0.2 -1.1
Angina 1.7 2.3 3.0 1.2 -1.7
Medication for hormone replacement therapy 0.5 0.5 1.0 1.0 0.2
Vitamin and mineral supplements 0.9 1.2 1.2 -1.1 1.1
Supplements: Zinc 0.5 0.5 0.7 -0.9 -0.5
Medication: Co-codamol 1.3 1.5 2.1 0.9 -1.5
Medication: Metformin 1.9 2.6 5.0 0.4 -2.2
Diabetes (father) 0.6 0.8 1.2 -0.5 1.1
Diabetes (mother) 0.3 0.4 0.8 -0.1 -0.9
Severe depression (siblings) 0.3 0.3 0.4 -0.6 0.5
Pack years adult smoking proportion 3.6 5.5 6.6 2.1 -2.6
Impedance of leg (right) 0.1 0.3 0.5 -0.3 -0.7
Leg fat-free mass (left) 0.2 1.0 1.4 0.8 -1.2
Trunk fat percentage 1.0 4.1 4.3 2.0 -2.1
Hand grip strength (right) 0.1 0.2 0.4 0.6 -0.3
Townsend deprivation index at recruitment 0.6 0.9 1.2 1.1 -0.7
Current tobacco smoking 0.1 0.2 0.2 0.5 0.3
Average weekly fortified wine intake 0.4 0.5 0.7 0.9 -0.4
Maternal smoking around birth 1.1 1.6 1.7 1.3 -1.2
Fed-up feelings 0.3 0.5 0.9 0.4 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.0 1.0 -0.4
Relative age voice broke 1.9 2.9 4.5 -1.2 2.1
Taking other prescription medications 1.2 1.8 2.4 1.1 -1.6
Age when periods started (menarche) 0.4 0.9 1.3 -0.7 1.2
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 0.0 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.6 1.2 -0.3
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.1 -0.1 0.3
Qualifications: CSEs or equivalent 0.0 0.0 0.0 0.1 0.1
Serious illness, injury or assault to yourself 1.0 1.2 1.3 1.0 -1.1
High blood pressure 0.6 1.6 3.0 1.7 -0.5
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 1.1 0.3
Multivitamins +/- minerals 1.9 2.4 2.5 1.6 -1.5
Stomach or abdominal pain in last month 1.3 1.6 2.5 1.6 -0.8
Supplements: Glucosamine 0.3 0.4 0.4 -0.6 -0.6
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 2.5 -1.2 1.6
Medication: Atenolol 0.0 0.0 0.1 0.2 0.2
Medication: Levothyroxine sodium 0.3 0.6 0.6 0.7 -0.8
Sitting height 0.1 0.9 1.7 -0.3 -1.3
Chronic bronchitis/emphysema (father) 1.4 1.6 1.7 1.2 -1.3
High blood pressure (mother) 0.2 0.3 0.5 0.7 0.1
Body mass index (BMI) 0.4 1.5 1.7 1.1 -1.3
Impedance of leg (left) 0.0 0.1 0.2 0.0 -0.4
Leg predicted mass (left) 0.2 1.2 1.7 0.8 -1.3
Trunk fat mass 0.9 3.9 4.5 1.8 -2.1
Waist circumference 0.4 1.5 1.9 1.0 -1.4
Number of incorrect matches in round 2.8 4.6 5.9 1.8 -2.4
Past tobacco smoking 0.8 1.5 2.4 -1.6 0.7
Alcohol usually taken with meals 0.0 0.1 0.1 -0.4 -0.0
Nervous feelings 0.0 0.0 0.0 -0.2 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.8 1.4 0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.3 0.4
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 -0.2 -0.1
Had menopause 1.0 1.3 1.7 0.9 -1.3
Had other major operations 0.4 0.5 0.8 -0.3 0.9
Forced vital capacity (FVC) 0.1 0.4 0.5 0.7 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.6 1.3 -0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.8 -0.0 -0.9
Qualifications: None of the above 0.1 0.2 0.4 0.6 -0.1
Financial difficulties in last 2 years 2.6 3.5 4.9 1.4 -2.2
Mouth/teeth dental problems 0.5 0.7 1.4 -1.2 0.1
Heart attack 2.2 2.8 3.1 1.6 -1.8
Allergy 0.4 1.0 2.0 -1.4 -0.0
Pain all over the body in last month 1.0 1.1 1.2 1.0 1.1
Diabetes (self-reported) 2.3 3.6 6.7 0.7 -2.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.5 -0.2 0.7
Medication: Ramipril 0.8 1.0 1.8 0.4 -1.4
Medication: Simvastatin 0.1 0.1 0.1 -0.3 -0.2
Fluid intelligence score 1.0 2.1 4.2 -2.0 -0.3
Illnesses of siblings 0.7 0.9 1.5 -1.2 0.6
Neuroticism score 0.0 0.0 0.1 0.2 -0.3
Weight 0.4 2.1 2.5 1.3 -1.6
Impedance of arm (right) 0.0 0.0 0.0 0.1 -0.1
Arm fat percentage (right) 0.5 2.1 2.3 1.4 -1.5
Trunk fat-free mass 0.1 0.4 0.6 0.3 -0.8
Hip circumference 0.2 1.0 1.6 0.6 -1.3
Time employed in main current job 0.6 0.7 0.9 -1.0 0.6
Alcohol intake versus 10 years previously 0.2 0.3 0.5 0.2 0.7
Father’s age at death 0.0 0.1 0.1 0.2 0.3
Worrier / anxious feelings 0.1 0.2 0.2 -0.5 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.3 -0.4 0.6
Falls in the last year 4.6 6.2 8.1 2.1 -2.9
Hair/balding pattern: Pattern 3 0.5 0.7 0.8 0.9 -0.8
Number of live births 0.3 0.4 0.5 0.7 0.6
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.1 0.2 -0.1
Pulse rate 0.5 0.8 0.9 0.8 -1.0
Happiness 0.2 0.3 0.6 0.1 -0.8
Noisy workplace 0.6 0.8 1.3 1.1 0.6
Qualifications: A levels/AS levels or equivalent 1.5 3.4 4.5 -2.1 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.3 -0.5 -0.6
Mouth/teeth dental problems: Dentures 1.6 2.7 5.1 2.3 -0.5
Asthma 0.2 0.4 0.5 0.6 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.6 -0.7 0.7
Medication: Cholesterol lowering 2.0 3.1 5.1 1.1 -2.3
Depression (self-reported) 0.1 0.1 0.1 -0.3 0.2
Medication: Lansoprazole 0.1 0.1 0.2 -0.5 -0.1
Prospective memory result 5.1 6.2 10.3 3.2 -1.5
Lung cancer (father) 0.5 0.6 1.1 -0.5 -1.0
Illnesses of mother 0.2 0.2 0.4 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.2 0.3 0.5 -0.2
Pulse wave Arterial Stiffness index 3.1 3.6 3.9 2.0 -1.8
Impedance of arm (left) 0.0 0.1 0.2 -0.3 0.4
Arm fat mass (right) 0.7 2.7 3.1 1.5 -1.8
Trunk predicted mass 0.1 0.4 0.7 0.3 -0.8
Standing height 0.1 0.9 1.2 0.7 -1.1
Length of working week for main job 2.2 2.5 3.9 2.0 -1.0
Exposure to tobacco smoke at home 0.5 0.5 1.0 1.0 0.1
Breastfed as a baby 1.1 1.4 2.3 -1.5 0.7
Tense / ‘highly strung’ 1.2 1.9 2.1 1.3 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.0 -0.4 -1.0
Hair/balding pattern: Pattern 4 0.4 0.9 1.8 -1.3 0.2
Birth weight of first child 2.2 4.0 4.1 2.0 -2.0
Peak expiratory flow (PEF) 0.1 0.3 0.4 -0.6 0.6
Pulse wave reflection index 0.6 0.7 1.1 0.7 -1.0
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 0.6 0.0
Loud music exposure frequency 0.2 0.2 0.4 -0.6 0.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.5 -0.7 -0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.5 0.7 -0.4
Blood clot in the leg (DVT) 0.7 0.9 1.1 1.1 -0.9
Medication: Paracetamol 0.5 0.8 1.6 0.1 1.3
Headache pain in last month 0.4 0.6 1.1 -1.1 -0.3
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 4.3 -1.4 2.1
Glaucoma (self-reported) 1.7 1.9 3.9 -0.0 2.0
Gout (self-reported) 3.6 5.0 9.1 0.9 -3.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.9 -0.3
Medication: Amlodipine 2.0 2.8 3.3 1.8 -1.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.0 -0.0 1.0
Birth weight 0.2 0.5 0.7 -0.5 0.8
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.4 0.6 -0.6
High blood pressure (siblings) 1.6 2.3 4.3 2.1 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.3 0.5 0.7 -0.3
Body fat percentage 0.8 3.2 3.5 1.7 -1.9
Leg fat percentage (right) 0.5 2.0 3.1 1.0 -1.8
Arm fat-free mass (right) 0.3 1.5 2.0 1.0 -1.4
Exposure to tobacco smoke outside home 1.8 2.4 2.7 1.6 -1.4
Comparative body size at age 10 0.5 1.4 2.2 -0.7 1.5
Number of full brothers 1.3 1.7 1.8 -1.3 1.3
Worry too long after embarrassment 0.0 0.1 0.1 -0.3 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 4.4 1.1 -2.1
Wheeze or whistling in the chest in last year 0.5 0.9 1.8 0.3 1.3
Number of children fathered 1.3 1.5 2.9 -0.3 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.6 0.8 -0.8
Age at first live birth 0.4 0.7 1.4 -1.2 0.3
Pulse wave peak to peak time 2.6 3.1 3.3 -1.8 1.7
Health satisfaction 0.1 0.1 0.1 0.3 0.3
Shortness of breath walking on level ground 0.1 0.1 0.1 -0.3 0.3
Qualifications: College or University degree 0.9 2.9 4.0 -1.4 2.0
Eye problems/disorders: None of the above 2.2 2.5 4.4 0.8 -2.1
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.2 0.6 1.1
Emphysema/chronic bronchitis 1.0 1.1 1.6 0.8 1.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 -0.3 0.5
Neck or shoulder pain in last month 2.1 3.0 4.6 -1.2 2.1
Medication: Blood pressure 2.6 4.5 5.9 1.8 -2.4
Angina (self-reported) 1.3 1.7 1.9 1.2 -1.4
Migraine (self-reported) 1.3 1.7 3.2 0.3 -1.8
Medication: Ibuprofen 0.0 0.0 0.0 -0.1 0.2
Medication: Allopurinol 3.6 4.9 6.4 1.8 -2.5
Medication: Omeprazole 0.2 0.2 0.4 0.6 -0.3
Medication: Seretide 50 evohaler 0.4 0.4 0.7 0.3 0.9
Mean time to correctly identify matches 0.6 1.2 2.3 1.5 -0.4
Heart disease (mother) 0.9 1.1 1.5 1.2 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 2.4 -1.6 0.8
Whole body fat mass 0.8 3.5 4.4 1.6 -2.1
Leg fat mass (right) 0.6 2.4 3.3 1.2 -1.8
Arm predicted mass (right) 0.4 1.8 2.3 1.2 -1.5
Pulse rate, automated reading 1.8 5.9 8.9 1.7 -3.0
Alcohol intake frequency. 1.6 3.7 6.7 -2.6 0.8
Comparative height size at age 10 0.4 2.0 3.5 0.7 -1.9
Number of full sisters 3.0 3.6 4.4 2.1 -1.7
Suffer from ‘nerves’ 0.2 0.3 0.5 0.0 -0.7
Overall health rating 0.4 1.0 1.5 1.2 -0.7
Chest pain or discomfort 0.3 0.4 0.8 0.2 0.9
Had major operations 0.5 0.6 1.1 -1.1 0.3
Age at last live birth 0.5 0.8 1.5 -1.2 0.3
Family relationship satisfaction 0.8 1.0 1.9 -0.4 -1.4
Leg pain on walking 2.5 3.1 5.9 -0.5 2.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.7 -0.8 0.5
Commuting to job workplace: Car/motor vehicle 0.7 0.7 0.9 0.8 -1.0
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 2.5 -0.5 1.6
Medication: Aspirin 1.1 1.4 2.9 0.2 -1.7
Supplements: Vitamin C 0.3 0.3 0.5 0.7 0.4
Knee pain experienced in last month 0.2 0.3 0.6 -0.0 -0.8
Hypertension (Self-reported) 0.8 2.3 4.5 2.1 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 -0.8 0.3
Illnesses of father: Heart disease 0.3 0.4 0.6 -0.5 0.8
Illnesses of siblings: Diabetes 0.2 0.3 0.5 0.1 0.7
Smoking status: Previous 0.8 1.2 1.5 1.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.3 0.3
Whole body fat-free mass 0.2 1.0 1.4 0.7 -1.2
Leg fat-free mass (right) 0.2 1.2 1.3 1.1 -1.1
Arm fat percentage (left) 0.4 1.6 1.8 1.1 -1.4
Average weekly red wine intake 0.7 1.1 1.1 -1.1 1.0
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.3 -0.7 1.5
Mood swings 0.5 1.0 1.6 1.3 -0.6
Loneliness, isolation 0.8 1.0 1.3 1.1 -0.9
Long-standing illness, disability or infirmity 0.9 1.4 2.8 0.3 -1.7
Ever had bowel cancer screening 0.4 0.4 0.8 -0.2 -0.9
Diabetes diagnosed by doctor 3.7 6.1 11.6 0.8 -3.4
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.5 1.6 -0.1
Friendships satisfaction 0.2 0.3 0.4 -0.7 0.4
Qualifications: nursing, teaching 0.9 1.4 1.5 -1.2 1.1
Commuting to job workplace: Walk 0.9 1.0 1.5 -1.2 0.7
Eye problems/disorders: Cataract 1.2 1.4 2.5 -0.5 1.6
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 2.6 -1.5 1.6
Medication for cholesterol 0.3 0.4 0.8 -0.3 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.1 0.5 -1.0
Back pain experienced in last month 0.7 1.0 1.9 -1.4 0.1
Mineral and other dietary supplements 0.4 0.5 1.0 0.0 1.0
Breast cancer (self-reported) 0.2 0.2 0.4 0.0 -0.7
Asthma (self-reported) 0.3 0.6 1.1 1.0 0.2
Osteoporosis (self-reported) 0.5 0.7 0.7 -0.8 -0.8
Osteoarthritis (self-reported) 0.4 0.5 1.0 1.0 0.0
Medication: Aspirin 0.8 1.0 2.0 0.3 -1.4
Medication: Gliclazide 0.7 0.8 1.2 0.7 -1.1
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 -0.2 -0.1
Smoking status: Current 0.1 0.2 0.3 0.5 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 3.1 -1.8 -0.2
Whole body water mass 0.1 0.7 1.0 0.7 -1.0
Leg predicted mass (right) 0.2 1.1 1.2 1.0 -1.1
Arm fat mass (left) 0.6 2.5 3.2 1.3 -1.8
Number of self-reported non-cancer illnesses 2.8 4.8 5.2 2.1 -2.3
Average weekly champagne plus white wine intake 1.8 2.5 3.2 -1.3 1.8
Miserableness 0.4 0.7 1.2 -0.4 1.1
Guilty feelings 1.2 1.8 3.2 0.7 1.8
Wears glasses or contact lenses 0.9 1.0 1.6 1.3 -0.7
Ever taken oral contraceptive pill 0.0 0.0 0.1 -0.0 0.3
Hearing aid user 0.0 0.0 0.0 -0.2 0.1
Mother’s age at death 2.8 3.6 4.3 -1.7 2.1
Financial situation satisfaction 0.5 0.7 0.8 0.7 0.9
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 -0.2 0.7
Commuting to job workplace: Public transport 1.7 2.0 4.0 0.3 2.0
Eye problems/disorders: Glaucoma 0.8 1.0 1.1 1.0 0.9
Medication: Blood pressure 0.6 1.1 2.1 1.5 -0.3
Pain type(s) experienced in last month: Hip pain 4.1 5.2 5.5 2.4 -2.2
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.6 0.4 -1.6
High cholesterol (Self-reported) 0.0 0.0 0.0 -0.1 -0.1
Medication: Bendroflumethiazide 0.6 0.9 1.7 1.3 0.3
Medication: Paracetamol 0.5 0.8 1.2 1.1 0.7
Medication: Lisinopril 3.4 4.4 6.6 1.5 -2.6
Medication: Atorvastatin 4.7 5.8 7.1 2.1 -2.7
Illnesses of father: High blood pressure 0.4 0.4 0.8 0.3 0.9
Alcohol drinker status: Never 1.5 1.8 3.5 -1.9 0.2
Ever smoked 0.7 1.2 2.3 1.5 -0.1
Basal metabolic rate 0.2 1.1 1.6 0.8 -1.3
Leg fat percentage (left) 0.6 2.0 2.5 1.3 -1.6
Arm fat-free mass (left) 0.4 2.1 2.6 1.3 -1.6
Number of operations (self-reported) 0.1 0.2 0.4 -0.6 0.2
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.1 -0.1
Irritability 0.6 1.0 1.1 1.1 -0.9
Risk taking 0.6 0.9 1.6 1.3 0.4
Ever had prostate specific antigen (PSA) test 1.5 1.7 2.5 -1.6 1.0
Fractured/broken bones in last 5 years 0.1 0.1 0.1 -0.0 0.4
Age started oral contraceptive pill 0.4 0.6 0.6 -0.7 0.8
Diastolic blood pressure, automated reading 1.6 5.0 7.0 2.7 -1.7
Ever depressed for a whole week 1.2 1.5 2.5 0.7 -1.6
Unable to work because of sickness or disability 0.6 0.7 1.1 1.0 0.6
Commuting to job workplace: Cycle 0.1 0.1 0.1 0.3 0.2
Myopia 0.3 0.4 0.7 -0.1 -0.9
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.0 -1.7 0.9
Cholesterol lowering medication 0.4 0.5 0.7 -0.6 0.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.3 0.5 -0.6
Pain experienced in last month 0.1 0.2 0.3 0.3 -0.5
Supplements: Calcium 0.5 0.5 0.6 0.6 -0.8
Basal cell carcinoma (self-reported) 0.8 0.9 1.8 0.0 1.4
Heart attack/myocardial infarction (self-reported) 1.5 2.0 2.2 1.3 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.2 1.1 -0.9
Heart disease (siblings) 0.2 0.3 0.5 -0.7 0.1
Alcohol drinker status: Previous 0.5 0.6 1.2 1.1 0.2
Pack years of smoking 3.6 5.3 6.8 1.9 -2.6
Impedance of whole body 0.0 0.1 0.2 0.2 -0.4
Leg fat mass (left) 0.7 2.6 3.2 1.4 -1.8
Arm predicted mass (left) 0.4 1.9 2.1 1.3 -1.4