Hub : Genes

BOLA3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.3290	0.0820	5.8e-06	0.075	NA	0.079	NA	0.085	0.00028	NA	2.1e-04	NA	0.00012
2	GTEx	Heart Left Ventricle	0.2135	0.0783	3.9e-03	0.005	NA	-0.005	NA	0.001	0.16000	NA	9.3e-01	NA	0.28000
3	TCGA	Lung Squamous Cell Carcinoma	0.0294	0.0165	5.5e-03	0.021	0.011	0.006	NA	0.011	0.00160	0.01700	5.7e-02	NA	0.01900
4	TCGA	Pancreatic Adenocarcinoma	0.1250	0.0640	2.9e-03	0.066	0.071	0.081	NA	0.074	0.00100	0.00063	2.7e-04	NA	0.00049
5	TCGA	Skin Cutaneous Melanoma	0.4520	0.1750	3.3e-03	0.028	0.056	0.159	NA	0.066	0.06000	0.01300	4.8e-05	NA	0.00790

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	5.5	-0.1	0.7	-2.4	-0.3	1.9
Bipolar Disorder or Schizophrenia	0.6	1.5	2.9	1.1	0.6	-1.1	-1.7	1.4
Depressed Affect (Nagel 2018)	1.6	3.3	7.0	1.2	1.8	2.7	-1.7	-1.3
Depression (Nagel 2018)	1.3	2.0	6.6	-0.4	0.4	1.7	-0.4	-2.6
Intelligence (Savage-Jansen 2018)	1.7	5.1	7.6	-2.8	-2.6	-2.6	2.1	0.2
Neuroticism (Nagel 2018)	1.4	3.3	5.8	1.3	2.4	2.2	-1.9	-0.8
Schizophrenia (2018)	0.5	1.1	3.0	1.5	0.2	0.5	-1.7	0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.6	0.9	-0.3	1.6	-0.8	-0.4
Worry (Nagel 2018)	0.1	0.3	0.4	-0.5	0.6	-0.5	-0.4	0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	-0.9	1.2	-0.2	-1.0	0.3
Alzheimer’s Disease (in father)	1.2	1.3	4.8	0.1	-0.2	-2.2	1.2	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	-1.2	0.3	-1.2	0.3	0.2
Crohns Disease (2017)	1.2	2.7	5.2	-1.0	1.4	-2.2	0.7	2.3
Irritable Bowel Disease (IBD)	0.5	1.2	1.8	-1.4	-0.5	-1.3	0.7	1.3
Ulcerative Colitis (UC)	0.4	0.8	2.2	-1.1	-1.5	-0.4	0.5	0.2
Major Depression (MDD)	0.6	0.7	1.3	-1.1	-1.0	-0.5	0.8	-0.5
Reaction Time	1.5	2.8	6.3	0.5	0.3	2.3	-1.4	-2.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	6.5	-1.3	-2.5	-1.2	0.9	0.6
Breast Cancer	0.3	0.7	1.3	0.0	-0.9	-1.1	1.0	-0.5
Ovarian Cancer	1.9	2.6	4.7	1.4	2.2	1.5	-1.9	-0.4
Prostate Cancer	1.9	2.7	5.3	1.9	1.6	1.4	-2.3	-0.3
Age at First Birth	0.3	0.4	1.3	0.1	0.5	-1.1	0.2	0.6
Bipolar Disorder (2011)	2.8	2.7	5.3	2.3	1.7	0.0	-2.3	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	-0.2	0.3	-1.4	-0.2	1.9
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.4	0.1	0.3	0.6	0.7
Crohns Disease (2012)	0.9	1.4	2.5	-0.8	0.8	-1.6	1.2	1.4
Mean Putamen Volume	1.8	2.0	4.5	2.1	1.8	-0.3	-1.2	0.9
Fasting Glucose	1.2	1.4	4.2	-0.3	0.4	-2.1	0.6	1.4
HbA1C	0.9	1.0	2.1	-1.4	0.3	-1.3	0.5	1.0
HDL Cholesterol	1.6	2.6	6.8	-1.1	-1.4	0.4	1.7	-2.6
LDL Cholesterol	0.2	0.4	1.2	-0.5	-0.3	-1.1	0.1	0.6
Lupus	0.2	0.2	0.9	0.3	-0.9	0.2	0.1	-0.4
Neuroticism (2016)	1.0	1.5	3.2	0.7	1.8	0.8	-1.4	1.1
Primary Biliary Cirrhosis	0.2	0.4	0.9	0.7	-0.3	-0.9	-0.3	0.5
Rheumatoid Arthritis	1.2	1.7	5.1	0.5	-0.2	2.3	-0.6	-1.7
Schizophrenia (2014)	0.2	0.5	1.0	0.9	-0.3	-0.2	-1.0	0.7
Triglycerides	1.7	2.8	5.6	-2.0	-1.4	-1.6	2.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	0.0	1.0	-1.4	0.7	0.8
Ulcerative Colitis	0.3	0.4	1.3	-0.2	-1.2	-0.7	-0.1	0.2
Blood Eosinophil Count	1.1	8.6	16.2	4.0	0.9	3.8	-3.4	-0.4
Blood Platelet Count	0.8	9.4	38.7	1.1	-2.1	-6.2	1.2	1.2
Blood Red Count	0.3	3.4	6.8	-1.3	-1.7	-2.6	1.6	1.7
Blood White Count	0.5	3.9	6.8	-2.6	-2.0	-1.4	2.2	-1.2
Heel T-Score	0.2	1.5	3.7	-0.1	1.2	-1.9	0.1	1.4
BMI	0.2	1.2	3.2	-0.4	-1.3	-1.8	0.9	-0.2
Height	1.1	21.6	40.6	6.4	2.0	6.2	-4.9	1.0
Waist Hip Ratio (WHR)	0.4	1.6	3.2	1.5	1.8	0.5	-1.5	0.3
Systolic Blood Pressure	0.3	1.3	2.7	-1.1	-0.2	-1.6	1.5	0.6
Smoking Status	1.3	3.2	7.9	1.1	-0.1	2.8	0.0	-2.6
Allergy or Eczema	0.5	1.4	4.4	1.4	-0.1	-0.6	-0.3	2.1
Cardiovascular Disease	0.7	2.4	3.3	-1.7	-1.6	-0.7	1.7	-1.8
Hypothyroidism (self reported)	0.6	1.4	3.0	1.3	1.1	1.7	-1.1	-0.1
Respiratory disease	2.8	6.2	10.2	2.9	1.9	1.9	-3.2	2.3
Type 2 Diabetes (T2D) (2018)	1.9	3.6	6.4	-2.4	-2.5	0.6	1.2	-2.0
Lung FEV1/FVC ratio	0.1	0.5	1.3	-0.2	-0.9	-0.4	1.1	-0.6
Lung FVC	0.1	0.7	1.0	-1.0	0.8	-0.7	0.5	-0.9
Neuroticism	0.6	1.4	3.0	0.9	1.7	1.1	-1.2	0.7
Chronotype (morning person)	1.0	2.2	5.8	0.9	-0.7	-2.4	0.8	1.8
Hair Pigment	0.0	0.2	0.4	0.1	-0.3	-0.1	0.6	-0.6
Tanning	0.1	1.4	4.4	0.2	-1.2	0.9	0.4	-2.1
Hand grip strength (left)	0.4	1.0	2.7	0.8	0.6	-0.9	0.6	1.6
Number of treatments/medications taken	1.1	2.0	3.8	1.0	1.6	1.6	-2.0	-0.2
Average weekly spirits intake	1.2	1.5	4.4	0.3	-0.4	1.1	-2.1	-1.2
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.3	-0.4	-0.4	0.7	0.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	-1.1	0.5	1.0	-0.5	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.6	-0.7	1.3	0.4	0.3	-0.8
Relative age of first facial hair	0.8	1.7	2.6	1.3	1.4	1.6	-1.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	0.6	-0.2	-0.3	0.1	0.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.5	1.2	-0.7	1.6	-0.4	-0.0
Ever had hysterectomy (womb removed)	1.4	1.6	3.2	-0.0	1.6	1.8	-1.1	-1.0
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.3	0.0	-0.8	0.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	-1.5	-0.3	1.3	-0.2	-0.7
Angina	0.2	0.3	0.7	0.6	0.8	0.4	-0.3	-0.1
Medication for hormone replacement therapy	3.1	3.4	6.0	2.5	2.0	1.5	-2.1	0.6
Vitamin and mineral supplements	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.3	0.2
Supplements: Zinc	2.6	2.8	6.3	-0.1	0.5	-2.5	1.6	2.2
Medication: Co-codamol	2.0	2.3	5.6	-0.3	-1.8	-0.5	1.4	-2.4
Medication: Metformin	1.7	2.4	3.8	-1.7	-2.0	0.0	1.6	-1.7
Diabetes (father)	0.7	0.8	3.4	-1.9	0.1	-0.4	0.4	0.5
Diabetes (mother)	0.4	0.5	1.2	0.2	1.1	-0.6	-0.7	0.7
Severe depression (siblings)	1.3	1.5	3.2	-0.3	-1.1	-1.8	1.7	0.0
Pack years adult smoking proportion	0.6	1.0	1.4	0.8	1.2	1.1	-1.1	-0.0
Impedance of leg (right)	0.3	1.4	2.8	0.8	1.6	0.6	-1.7	0.9
Leg fat-free mass (left)	0.1	0.6	1.4	1.1	-1.2	0.5	-0.2	-0.2
Trunk fat percentage	0.1	0.2	0.5	-0.4	0.3	-0.7	-0.4	-0.5
Hand grip strength (right)	0.6	1.7	5.2	0.8	0.8	-1.2	0.7	2.3
Townsend deprivation index at recruitment	0.8	1.1	3.9	2.0	1.0	0.2	-0.6	-0.3
Current tobacco smoking	0.7	1.1	2.2	0.4	0.4	1.5	-1.5	-0.9
Average weekly fortified wine intake	0.9	1.0	2.3	-1.0	0.3	1.0	-0.8	-1.5
Maternal smoking around birth	1.8	2.6	6.1	0.6	0.2	2.5	-1.3	-2.2
Fed-up feelings	1.2	2.3	6.1	0.2	1.3	2.5	-1.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.9	0.2	0.6	1.3	-0.0	-2.0
Relative age voice broke	0.2	0.4	0.7	0.5	0.8	0.5	-0.7	0.4
Taking other prescription medications	2.3	3.6	7.1	1.8	1.0	2.5	-2.7	-0.1
Age when periods started (menarche)	1.6	3.9	11.7	0.4	0.1	3.4	-1.9	-1.9
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	4.9	1.2	1.4	2.1	-2.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.4	0.7	1.6	-1.9	-0.4	1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.3	0.6	0.2	0.5	0.8
Qualifications: CSEs or equivalent	0.2	0.2	0.6	-0.5	-0.6	0.3	0.0	-0.8
Serious illness, injury or assault to yourself	2.9	3.5	6.0	2.4	1.9	0.4	-2.1	1.8
High blood pressure	0.1	0.2	0.7	0.3	-0.6	-0.0	-0.0	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.7	1.6	-0.7	-0.6	0.3	1.6
Multivitamins +/- minerals	0.8	1.0	3.2	-0.0	-1.1	0.6	0.4	-1.8
Stomach or abdominal pain in last month	2.6	3.2	5.2	1.6	2.0	2.0	-2.3	-0.2
Supplements: Glucosamine	0.3	0.4	0.6	-0.7	-0.6	-0.7	0.8	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.8	0.0	0.4	-1.7	-0.2	0.2
Medication: Atenolol	1.5	1.9	3.6	1.2	1.8	-1.1	-0.3	1.9
Medication: Levothyroxine sodium	1.3	2.2	3.4	1.6	1.3	1.8	-1.9	0.0
Sitting height	0.3	2.0	3.7	1.9	0.0	1.9	-1.5	0.3
Chronic bronchitis/emphysema (father)	0.9	1.1	3.6	-0.1	-0.5	1.2	-0.5	-1.9
High blood pressure (mother)	0.4	0.5	0.7	-0.4	-0.8	-0.8	0.8	0.6
Body mass index (BMI)	0.2	0.8	2.8	-1.0	-0.5	-1.7	0.2	-0.1
Impedance of leg (left)	0.5	2.2	4.9	1.0	2.2	0.8	-1.9	1.0
Leg predicted mass (left)	0.1	0.6	1.5	1.1	-1.2	0.5	-0.2	-0.3
Trunk fat mass	0.0	0.2	0.5	0.2	0.3	-0.5	-0.7	-0.1
Waist circumference	0.2	0.7	1.5	0.4	0.5	-1.2	-1.0	0.7
Number of incorrect matches in round	0.1	0.2	0.7	-0.1	0.8	0.0	-0.3	0.6
Past tobacco smoking	1.6	2.9	7.3	-1.2	0.5	-2.2	-0.7	2.7
Alcohol usually taken with meals	1.6	2.6	5.4	0.9	2.3	-0.5	-1.1	2.3
Nervous feelings	0.3	0.5	0.8	-0.7	-0.2	-0.9	0.8	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.3	0.7	0.5	1.5	-0.9	-0.6
Hearing difficulty/problems with background noise	0.4	0.7	1.6	-0.3	0.9	0.9	0.5	-1.2
Hair/balding pattern: Pattern 2	0.6	0.8	2.1	-1.4	-0.2	0.6	1.1	-0.5
Had menopause	0.2	0.2	0.4	0.4	-0.2	-0.5	0.5	0.6
Had other major operations	0.7	0.9	1.4	1.2	-0.6	1.2	-1.1	-0.0
Forced vital capacity (FVC)	0.3	1.2	3.2	0.6	-0.5	1.8	-0.3	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.9	0.2	0.5	-1.6	0.6	1.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	-0.1	0.4	-1.2	0.3	-0.8
Qualifications: None of the above	0.8	1.8	3.1	1.2	1.2	1.7	-1.8	0.2
Financial difficulties in last 2 years	0.2	0.3	0.8	0.1	-0.5	0.2	0.4	-0.9
Mouth/teeth dental problems	3.3	5.1	9.8	-3.1	-0.9	-2.9	2.3	1.1
Heart attack	1.0	1.3	2.4	1.5	0.8	1.5	-1.1	-0.2
Allergy	1.0	2.2	5.8	-2.4	-0.4	-0.2	1.1	-2.0
Pain all over the body in last month	0.5	0.6	1.8	-0.3	-0.5	0.5	0.6	-1.3
Diabetes (self-reported)	2.0	3.1	6.6	-2.1	-1.8	0.7	0.9	-2.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	0.5	1.2	-0.7	-0.6	1.2
Medication: Ramipril	0.2	0.3	0.7	0.8	-0.1	0.0	-0.8	0.2
Medication: Simvastatin	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.3	-0.1
Fluid intelligence score	0.5	1.0	2.7	-0.0	-1.6	-1.4	0.4	0.6
Illnesses of siblings	1.3	1.9	3.6	-1.5	-0.9	-1.9	1.6	0.6
Neuroticism score	0.7	1.6	2.5	1.0	1.6	1.3	-1.5	0.5
Weight	0.1	0.3	0.8	0.7	-0.1	-0.1	-0.9	0.3
Impedance of arm (right)	0.1	0.3	0.8	-0.2	0.3	0.9	-0.4	-0.8
Arm fat percentage (right)	0.2	0.9	2.2	-1.4	-0.4	-1.5	0.3	-0.3
Trunk fat-free mass	0.5	2.8	7.8	2.8	0.2	1.3	-1.8	1.1
Hip circumference	0.2	0.8	2.5	-0.6	-0.9	-1.6	0.2	0.4
Time employed in main current job	1.2	1.4	4.5	0.3	2.1	0.0	-1.5	0.4
Alcohol intake versus 10 years previously	0.3	0.5	1.1	0.9	0.2	0.7	-1.0	-0.1
Father’s age at death	0.7	0.9	3.3	1.8	0.4	0.4	-0.5	0.7
Worrier / anxious feelings	0.3	0.6	1.3	0.2	0.7	0.3	-1.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.3	-0.4	0.1	1.1	-1.2	0.4
Falls in the last year	0.1	0.1	0.4	-0.1	-0.7	-0.1	-0.2	0.0
Hair/balding pattern: Pattern 3	0.2	0.4	1.6	-0.3	-0.2	-0.1	0.3	-1.2
Number of live births	0.7	0.9	3.0	1.7	-0.3	0.7	-0.9	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.5	0.2	-0.6	1.2	-0.2	-1.2
Pulse rate	0.7	1.2	2.1	-0.6	-1.5	-1.1	1.5	-0.5
Happiness	0.2	0.2	0.6	0.6	-0.3	-0.1	0.1	-0.8
Noisy workplace	0.2	0.2	0.6	-0.3	0.1	0.5	-0.4	-0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.5	-0.9	0.3	-1.6	1.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	-0.3	0.1	-1.3	-0.7	1.1
Mouth/teeth dental problems: Dentures	2.7	4.5	10.8	1.7	1.5	3.3	-2.4	-0.9
Asthma	3.4	6.6	11.8	2.4	2.3	2.4	-3.4	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	4.3	0.4	1.0	1.3	-2.1	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.1	-1.1	-0.4	0.7	-0.0	-1.0
Depression (self-reported)	0.8	1.0	2.3	-1.5	-1.3	-0.5	0.6	0.5
Medication: Lansoprazole	0.9	1.1	2.0	-0.3	1.4	0.8	-1.3	-0.9
Prospective memory result	1.3	1.6	4.8	-0.1	0.6	2.2	-0.4	-1.7
Lung cancer (father)	2.7	3.1	7.5	1.7	2.7	-0.3	-1.6	1.6
Illnesses of mother	0.5	0.6	1.6	0.9	0.5	1.3	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.4	0.3	-0.0	0.7	-0.5	-1.2
Pulse wave Arterial Stiffness index	2.5	2.9	6.0	2.1	0.6	2.5	-1.0	-1.7
Impedance of arm (left)	0.1	0.3	0.8	-0.6	0.0	0.5	0.1	-0.9
Arm fat mass (right)	0.1	0.3	1.1	-0.4	-0.2	-1.0	-0.4	0.1
Trunk predicted mass	0.5	2.6	7.4	2.7	0.1	1.2	-1.8	1.1
Standing height	0.8	7.6	15.4	3.9	1.0	3.5	-2.9	1.0
Length of working week for main job	1.4	1.6	2.4	1.2	1.3	1.5	-1.4	0.5
Exposure to tobacco smoke at home	1.6	1.8	3.2	-1.4	-0.9	-0.7	1.8	-1.6
Breastfed as a baby	0.1	0.1	0.3	-0.1	0.6	-0.3	-0.1	0.4
Tense / ‘highly strung’	1.4	2.4	3.3	1.8	1.5	1.6	-1.8	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.5	0.3	0.2	-1.6	0.4	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	2.6	1.1	0.4	-1.6	-0.2	0.4
Birth weight of first child	1.2	2.2	6.4	1.0	-0.4	2.5	-1.4	-1.3
Peak expiratory flow (PEF)	0.2	0.6	2.3	-0.2	-0.5	0.4	-0.2	-1.5
Pulse wave reflection index	1.2	1.5	2.0	1.4	1.1	1.4	-1.4	-0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	1.0	1.4	-0.3	-0.6	0.3
Loud music exposure frequency	0.1	0.2	0.4	-0.2	0.6	-0.5	-0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.9	-1.9	-0.8	-2.2	2.0	-0.3
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	6.1	2.1	0.6	2.5	-1.9	-1.3
Blood clot in the leg (DVT)	0.6	0.7	2.1	-1.0	0.7	0.3	-0.0	-1.4
Medication: Paracetamol	0.2	0.4	1.9	-0.3	-0.1	0.2	0.1	-1.4
Headache pain in last month	0.2	0.3	0.9	0.4	0.7	0.3	-1.0	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.6	0.7	-0.4	-0.3	0.9
Glaucoma (self-reported)	0.6	0.7	3.0	0.2	-0.5	1.7	-0.3	-0.6
Gout (self-reported)	0.9	1.2	2.5	-1.6	-0.7	-0.2	1.0	-1.4
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	7.8	2.4	1.6	2.8	-2.2	-0.8
Medication: Amlodipine	0.9	1.2	2.9	0.7	0.7	1.3	-0.7	-1.7
Medication: Ventolin 100micrograms inhaler	6.4	8.2	18.6	2.2	2.7	3.0	-4.3	1.2
Birth weight	0.4	0.9	2.5	1.2	-0.6	0.3	-0.0	1.6
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.6	-0.6	1.9	1.0	-1.5	0.2
High blood pressure (siblings)	1.1	1.6	4.8	0.5	0.8	2.2	-1.3	-0.8
Forced vital capacity (FVC), Best measure	0.4	1.5	2.4	1.5	0.7	1.6	-1.3	-1.0
Body fat percentage	0.1	0.4	1.6	-0.6	0.3	-1.3	-0.2	-0.2
Leg fat percentage (right)	0.3	1.1	4.0	-0.7	0.5	-2.0	-0.1	0.9
Arm fat-free mass (right)	0.4	2.3	6.1	2.5	0.5	1.0	-1.8	1.1
Exposure to tobacco smoke outside home	1.3	1.7	3.4	1.9	1.8	0.6	-1.1	-0.4
Comparative body size at age 10	1.1	2.9	5.7	-2.1	-2.4	-1.2	1.4	-0.9
Number of full brothers	2.0	2.5	6.5	1.6	2.5	-0.2	-1.8	0.7
Worry too long after embarrassment	1.6	2.6	3.8	1.9	1.9	1.8	-1.6	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.8	-0.9	-0.2	-1.4	1.3	-0.9
Wheeze or whistling in the chest in last year	0.8	1.3	3.6	0.7	0.5	1.5	-1.9	-0.0
Number of children fathered	0.4	0.5	1.8	-0.5	0.0	-1.3	0.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.5	0.2	-0.8	0.3	-0.4
Age at first live birth	0.6	1.0	4.8	-2.2	-0.3	0.3	0.1	0.3
Pulse wave peak to peak time	2.5	2.9	5.4	-1.9	-0.5	-2.3	1.0	2.1
Health satisfaction	1.6	2.1	6.1	0.3	-1.3	1.5	0.2	-2.5
Shortness of breath walking on level ground	1.8	2.2	5.8	-1.1	-2.4	-0.1	1.3	-1.4
Qualifications: College or University degree	0.4	1.3	4.3	0.7	-0.6	-0.9	0.8	2.1
Eye problems/disorders: None of the above	0.2	0.2	0.7	-0.0	-0.9	0.4	0.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.8	0.5	-1.1	0.7	0.6	-1.4
Emphysema/chronic bronchitis	3.1	3.4	5.3	2.3	2.2	-0.2	-2.2	1.4
Medication for pain relief, constipation, heartburn	1.2	2.1	3.9	-0.6	-1.8	-1.4	2.0	1.0
Neck or shoulder pain in last month	0.8	1.1	1.5	1.2	-0.4	1.1	-1.1	-1.1
Medication: Blood pressure	0.6	1.0	2.7	-0.4	-1.1	0.8	0.2	-1.7
Angina (self-reported)	0.3	0.3	0.6	0.5	0.8	0.7	-0.5	-0.3
Migraine (self-reported)	0.7	0.8	2.0	-1.0	-0.1	-1.4	1.0	0.4
Medication: Ibuprofen	1.2	1.4	3.9	0.4	1.1	1.3	-2.0	-0.4
Medication: Allopurinol	0.9	1.3	2.3	-1.5	-1.2	0.1	0.5	-1.5
Medication: Omeprazole	1.4	1.6	2.6	1.6	1.4	1.5	-1.2	-0.2
Medication: Seretide 50 evohaler	4.8	5.6	12.0	2.7	2.0	2.2	-3.5	0.3
Mean time to correctly identify matches	1.7	3.2	8.5	0.3	0.1	2.6	-1.0	-2.9
Heart disease (mother)	0.1	0.2	0.4	0.3	0.4	-0.3	-0.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.4	1.0	-0.8	-1.8	1.3	0.5
Whole body fat mass	0.1	0.2	0.9	0.0	0.3	-0.9	-0.5	0.2
Leg fat mass (right)	0.1	0.3	1.1	-0.3	0.0	-1.1	-0.2	0.3
Arm predicted mass (right)	0.4	2.2	6.1	2.5	0.3	1.2	-1.6	1.0
Pulse rate, automated reading	0.9	3.0	8.1	-0.8	-2.8	-1.8	1.8	0.1
Alcohol intake frequency.	1.4	3.3	10.6	-0.7	0.1	-3.3	0.8	2.2
Comparative height size at age 10	0.8	4.6	11.4	3.4	0.5	1.0	-2.5	1.9
Number of full sisters	1.5	1.8	5.9	0.9	1.1	2.4	-0.6	-0.9
Suffer from ‘nerves’	0.3	0.5	1.3	-1.1	0.4	0.4	0.0	-0.9
Overall health rating	0.6	1.2	3.4	0.5	1.2	0.6	-1.8	-0.8
Chest pain or discomfort	0.6	0.8	1.9	0.6	0.1	1.4	-1.0	-0.9
Had major operations	1.3	1.5	6.2	-0.1	1.1	-0.2	-0.3	2.5
Age at last live birth	0.9	1.2	3.1	0.5	1.3	0.6	-1.8	0.9
Family relationship satisfaction	1.1	1.3	3.3	0.4	0.9	1.8	-1.4	-0.6
Leg pain on walking	0.7	0.8	2.2	-1.0	-0.6	0.8	-0.3	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.4	-2.1	-1.3	-1.7	1.7	0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.2	-1.5	0.4	1.4	-0.4	-1.2
Illness, injury, bereavement, stress in last 2 years	3.9	4.8	7.2	-2.7	-2.3	0.1	2.1	-2.7
Medication: Aspirin	2.6	3.5	7.1	1.1	2.7	1.4	-2.7	0.3
Supplements: Vitamin C	0.2	0.3	1.3	-0.2	-0.1	1.1	0.2	0.1
Knee pain experienced in last month	0.7	1.1	3.3	-0.3	-0.4	1.8	-1.2	-0.9
Hypertension (Self-reported)	0.1	0.4	1.1	-0.2	-0.9	0.3	0.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.3	3.5	1.2	1.9	0.3	-0.6	1.1
Illnesses of father: Heart disease	0.5	0.8	1.4	-0.9	-0.1	-0.6	1.0	1.2
Illnesses of siblings: Diabetes	3.0	3.7	7.7	1.6	1.3	2.8	-2.5	-0.7
Smoking status: Previous	1.2	1.8	4.5	1.1	-0.4	1.5	1.0	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.3	0.2	-1.2	0.2	0.2	0.1
Whole body fat-free mass	0.3	1.8	5.5	2.3	-0.2	1.1	-1.3	0.6
Leg fat-free mass (right)	0.1	0.7	1.7	1.3	-1.0	0.8	-0.4	-0.2
Arm fat percentage (left)	0.3	1.3	3.0	-1.6	-0.6	-1.7	0.6	-0.4
Average weekly red wine intake	0.1	0.2	0.5	0.2	-0.1	0.7	0.0	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.3	-0.3	0.5	0.1	0.5
Mood swings	1.3	2.4	7.6	0.6	2.8	0.9	-1.6	0.8
Loneliness, isolation	0.2	0.3	0.5	0.6	0.4	0.7	-0.4	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	1.1	0.2	0.5	-0.3	-1.0	0.2
Ever had bowel cancer screening	0.6	0.7	1.1	0.5	1.1	-0.7	-1.1	-0.7
Diabetes diagnosed by doctor	1.6	2.7	4.5	-2.1	-2.0	0.7	0.9	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	0.3	-0.3	1.5	-0.8	-1.2
Friendships satisfaction	0.6	0.7	1.5	0.9	0.4	1.2	-1.1	-0.1
Qualifications: nursing, teaching	0.4	0.6	1.7	-0.7	0.1	-1.3	0.1	0.7
Commuting to job workplace: Walk	2.0	2.2	5.3	2.3	0.8	0.4	-1.7	1.4
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.8	0.8	-0.5	0.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.5	1.6	-0.4	-1.2	-0.2	1.5
Medication for cholesterol	0.7	1.0	2.4	-1.0	-1.5	-0.5	1.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.4	-0.7	-1.2	0.4	0.0	-0.2
Back pain experienced in last month	0.5	0.7	3.1	-0.5	0.2	-1.8	-0.5	0.0
Mineral and other dietary supplements	3.0	4.0	9.9	1.1	1.8	2.4	-3.1	-0.5
Breast cancer (self-reported)	0.1	0.2	0.6	-0.8	0.1	0.4	-0.2	-0.2
Asthma (self-reported)	3.2	6.3	10.0	2.5	2.2	2.3	-3.2	2.3
Osteoporosis (self-reported)	1.1	1.4	2.9	1.3	0.9	1.1	-1.7	0.6
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.4	-0.4	-0.6	0.4	0.1
Medication: Aspirin	3.0	3.9	8.8	1.3	3.0	1.5	-2.6	0.1
Medication: Gliclazide	1.1	1.2	1.9	0.9	0.8	1.3	-1.4	-0.9
Illnesses of father: None of the above (group 1)	3.2	4.0	8.6	1.6	2.6	1.2	-2.9	0.7
Smoking status: Current	0.7	1.1	2.8	0.1	0.0	1.7	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.3	-1.0	0.0	-1.8	0.7	-1.1
Whole body water mass	0.3	1.7	4.8	2.2	-0.3	1.1	-1.3	0.6
Leg predicted mass (right)	0.1	0.7	1.8	1.3	-1.0	0.8	-0.4	-0.2
Arm fat mass (left)	0.1	0.3	1.0	-0.6	-0.5	-1.0	-0.1	-0.0
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	0.9	0.6	0.0	-0.9	0.7
Average weekly champagne plus white wine intake	0.9	1.2	2.8	-0.1	1.7	0.4	-1.0	1.5
Miserableness	1.2	2.0	3.4	1.2	1.5	1.7	-1.8	-0.4
Guilty feelings	1.9	2.8	9.5	-0.8	0.2	3.1	-0.2	-2.0
Wears glasses or contact lenses	0.6	0.7	2.3	0.7	0.3	-1.5	0.4	0.5
Ever taken oral contraceptive pill	2.7	3.0	5.9	0.5	-1.1	2.2	-1.6	-2.4
Hearing aid user	1.5	1.7	3.8	-1.7	-1.2	-0.5	2.0	0.4
Mother’s age at death	1.3	1.6	4.7	-0.6	-0.9	-2.2	1.3	0.7
Financial situation satisfaction	0.9	1.1	4.8	0.3	-0.1	2.2	-0.0	-0.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.1	0.6	-0.0	0.5	0.1
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.6	0.5	-0.5	0.2	-0.7
Eye problems/disorders: Glaucoma	0.5	0.5	1.2	-0.1	-1.1	1.1	0.4	-0.3
Medication: Blood pressure	0.2	0.3	0.9	0.2	0.9	0.5	-0.3	-0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.8	-0.5	-1.3	1.3	0.4	-1.9
Supplements: Fish oil (including cod liver oil)	2.7	3.5	10.1	-1.2	-1.5	-1.8	3.2	-0.8
High cholesterol (Self-reported)	0.2	0.4	0.9	0.7	1.0	0.2	-0.7	0.1
Medication: Bendroflumethiazide	0.2	0.3	0.9	-0.5	0.6	0.1	0.1	-1.0
Medication: Paracetamol	0.5	0.8	2.5	-0.8	0.0	0.9	0.0	-1.6
Medication: Lisinopril	1.5	1.9	4.2	-1.9	-1.2	0.6	0.3	-2.0
Medication: Atorvastatin	1.5	1.9	4.6	0.1	0.6	2.1	-1.3	-1.7
Illnesses of father: High blood pressure	2.9	3.6	8.5	-1.2	-2.9	0.9	1.9	-2.0
Alcohol drinker status: Never	1.9	2.3	5.6	-1.1	-0.7	-2.4	0.8	1.9
Ever smoked	1.3	2.2	5.0	1.5	-0.1	2.2	-0.2	-1.9
Basal metabolic rate	0.2	1.2	3.6	1.9	-0.3	0.8	-1.2	0.5
Leg fat percentage (left)	0.3	1.0	3.1	-0.5	0.8	-1.8	-0.5	0.8
Arm fat-free mass (left)	0.4	2.0	5.0	2.2	0.1	1.2	-1.6	0.9
Number of operations (self-reported)	2.0	3.0	6.5	2.1	1.6	-0.5	-1.2	2.5
Average weekly beer plus cider intake	1.6	2.3	4.9	-1.7	-2.2	0.5	1.0	-1.6
Irritability	1.2	2.0	4.1	1.4	1.4	2.0	-1.3	0.0
Risk taking	1.9	2.8	5.6	1.8	1.2	2.4	-1.6	-1.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.6	0.1	-0.4	-0.3	0.3
Fractured/broken bones in last 5 years	0.7	1.0	3.7	0.0	-0.0	1.9	-0.6	-0.8
Age started oral contraceptive pill	3.4	4.2	10.2	1.9	1.9	1.9	-3.2	0.4
Diastolic blood pressure, automated reading	0.2	0.6	1.6	0.2	-0.5	-1.3	1.0	0.7
Ever depressed for a whole week	1.5	1.8	3.1	-1.1	-1.4	-1.8	1.4	-0.9
Unable to work because of sickness or disability	0.6	0.8	1.8	0.9	0.2	-1.4	1.1	0.6
Commuting to job workplace: Cycle	0.4	0.4	0.9	0.7	0.2	1.0	0.4	-0.7
Myopia	0.1	0.1	0.2	0.4	-0.5	0.5	-0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.0	0.7	-0.2	-0.0	0.6
Cholesterol lowering medication	0.6	0.9	2.8	1.1	0.2	0.7	-1.7	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	1.3	1.1	1.3	-0.8	-0.2
Pain experienced in last month	1.1	1.8	3.5	-0.7	-0.3	-1.4	1.7	1.9
Supplements: Calcium	1.2	1.4	2.9	-0.7	-0.6	-1.6	1.7	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.5	0.4	-0.3	-0.7	0.9
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.3	1.5	0.7	1.3	-1.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	-1.1	0.8	0.5	-0.2	-1.3
Heart disease (siblings)	1.3	1.6	4.1	2.0	1.6	-0.3	-0.7	0.8
Alcohol drinker status: Previous	0.6	0.7	2.4	-0.4	-0.2	0.7	0.6	-1.5
Pack years of smoking	0.7	1.0	1.9	0.7	1.4	1.1	-1.3	-0.2
Impedance of whole body	0.1	0.6	1.5	0.3	1.2	0.9	-0.9	0.0
Leg fat mass (left)	0.1	0.2	0.8	-0.0	0.3	-0.9	-0.5	0.4
Arm predicted mass (left)	0.5	2.6	6.3	2.5	0.5	1.3	-1.9	1.1