TWAS hub - INO80B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0770	0.0390	9.4e-04	0.024	NA	0.021	NA	0.030	4.5e-03	NA	6.7e-03	NA	1.5e-03
2	GTEx	Adipose Visceral Omentum	0.2130	0.0780	4.2e-04	0.040	NA	-0.004	NA	0.052	3.9e-03	NA	6.5e-01	NA	1.1e-03
3	GTEx	Artery Aorta	0.1510	0.0490	4.0e-05	0.014	NA	0.083	NA	0.061	5.3e-02	NA	2.6e-05	NA	2.8e-04
4	GTEx	Esophagus Mucosa	0.1990	0.0590	3.3e-06	0.083	NA	0.067	NA	0.083	3.5e-06	NA	2.8e-05	NA	3.2e-06
5	GTEx	Lung	0.0551	0.0263	2.2e-03	0.012	NA	-0.002	NA	0.005	3.9e-02	NA	5.5e-01	NA	1.2e-01
6	GTEx	Skin Not Sun Exposed Suprapubic	0.0880	0.0380	2.5e-03	0.060	NA	0.022	NA	0.036	3.4e-04	NA	2.2e-02	NA	4.3e-03
7	GTEx	Skin Sun Exposed Lower leg	0.0450	0.0220	3.0e-03	0.026	NA	0.010	NA	0.020	3.0e-03	NA	4.5e-02	NA	7.5e-03
8	GTEx	Testis	0.0950	0.0510	7.4e-03	0.013	NA	0.005	NA	0.001	8.5e-02	NA	1.8e-01	NA	2.9e-01
9	GTEx	Thyroid	0.1000	0.0380	1.8e-05	0.058	NA	0.072	NA	0.057	3.1e-05	NA	3.7e-06	NA	3.3e-05
10	METSIM	Adipose	0.0970	0.0278	5.1e-13	0.083	0.080	0.082	0.081	0.083	1.8e-12	5.1e-12	2.7e-12	4.2e-12	1.9e-12
11	ROSMAP	Brain Pre-frontal Cortex	0.0617	0.0206	6.8e-08	0.065	0.058	0.048	0.060	0.053	8.0e-09	6.3e-08	6.9e-07	3.5e-08	1.9e-07
12	YFS	Blood	0.0155	0.0072	5.3e-04	0.006	0.011	0.003	0.011	0.006	3.8e-03	9.0e-05	3.1e-02	1.0e-04	4.2e-03
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0173	0.0139	7.0e-03	0.006	0.003	0.001	NA	0.001	6.0e-02	1.2e-01	2.1e-01	NA	2.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Mouth/teeth dental problems: Mouth ulcers	6.1	9.7	14.2	-2.6	-3.8	-2.0	-2.7	-3.4	-3.3	-3.5	-3.2	-2.9	-3.2	-3.5	-2.6	-3.4
Falls in the last year	5.4	7.3	13.2	-2.4	-2.3	-2.2	-2.5	-3.0	-3.1	-2.9	-1.9	-1.9	-2.7	-2.9	-3.6	-2.9
Blood Platelet Count	5.1	59.2	86.3	-7.3	-8.2	-6.1	-7.7	-8.3	-8.1	-9.3	-5.3	-7.1	-8.3	-8.6	-6.4	-8.3
Alzheimer’s Disease (including proxy)	4.8	7.0	10.6	2.9	2.2	0.8	2.9	2.7	2.8	3.1	2.0	2.1	2.8	3.3	3.1	2.8
Hayfever, allergic rhinitis or eczema	4.2	9.1	14.1	-2.9	-3.4	-1.2	-3.1	-3.5	-3.6	-3.8	-1.9	-2.7	-3.1	-3.6	-2.0	-3.2
Age at First Birth	4.0	5.8	8.6	2.3	1.7	1.8	2.3	2.9	2.8	2.5	2.2	2.0	2.9	2.7	2.5	2.2
Medication: Co-codamol	3.8	4.4	6.0	-2.4	-1.3	-1.4	-2.3	-2.3	-2.1	-2.1	-1.4	-2.3	-2.4	-2.3	-2.3	-2.0
Diabetes (father)	3.8	4.7	8.1	2.6	2.1	0.1	2.8	1.7	1.5	2.5	1.8	1.7	2.9	2.5	2.3	2.0
Allergy	3.8	8.8	15.0	2.8	3.3	1.8	2.9	3.4	3.4	3.9	1.4	2.8	3.0	3.6	1.9	3.4
Average weekly champagne plus white wine intake	3.8	5.2	8.1	2.8	2.6	1.5	2.8	2.1	2.4	2.8	1.0	2.0	2.5	2.5	2.0	1.9
Alzheimer’s Disease (in father)	3.6	3.9	6.4	2.0	1.6	0.6	2.0	2.3	2.5	2.4	1.2	0.9	1.8	2.4	2.2	2.4
Leg pain on walking	3.6	4.5	8.9	-1.4	-1.7	-2.0	-0.8	-2.5	-2.5	-1.9	-2.5	-0.9	-1.7	-2.5	-3.0	-2.7
Alzheimer’s Disease (in mother)	3.5	4.0	6.4	2.3	1.9	0.3	2.1	1.8	1.8	2.3	1.5	2.1	2.2	2.4	2.5	2.0
Time employed in main current job	3.5	4.0	6.7	2.3	2.1	0.2	2.6	1.7	2.1	2.0	1.6	2.5	2.0	1.9	2.4	1.4
High blood pressure (siblings)	3.4	5.0	8.1	2.1	1.7	2.7	1.8	2.9	2.5	2.5	1.8	1.4	2.4	2.3	1.4	2.8
Irritability	3.3	5.5	8.1	2.6	1.0	2.8	2.3	2.5	2.5	2.2	2.3	2.1	2.4	2.5	2.6	2.4
Pain experienced in last month	3.1	5.2	9.5	3.1	2.0	1.3	2.3	2.5	2.5	2.9	1.3	1.1	2.4	2.5	2.5	2.3
Hair/balding pattern: Pattern 2	3.0	3.8	6.3	1.9	2.0	0.2	2.4	1.8	1.8	2.1	1.7	1.5	1.7	2.5	2.3	2.4
Medication: Omeprazole	3.0	3.6	6.8	1.2	2.1	2.6	1.8	2.2	2.3	1.7	1.5	1.6	1.4	1.8	1.3	2.5
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	8.6	1.3	1.7	2.9	2.0	2.1	2.2	1.6	1.5	2.0	1.4	1.7	1.4	2.2
Bipolar Disorder (2011)	2.9	2.8	5.6	-1.9	-1.7	-2.4	-1.7	-1.8	-1.9	-1.6	0.0	-1.7	-1.7	-1.6	-1.3	-1.6
Medication: Atenolol	2.9	3.6	6.0	1.7	2.2	0.9	2.1	2.1	1.9	2.1	1.5	1.5	1.8	2.5	1.6	2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.8	8.8	-2.4	-2.5	-1.1	-2.9	-2.7	-2.9	-2.1	-3.0	-1.6	-1.8	-2.2	-2.2	-2.8
Supplements: Zinc	2.7	2.9	6.3	1.5	2.5	-0.5	1.5	1.9	1.9	1.8	2.0	0.8	1.3	1.6	2.2	1.6
Trunk fat-free mass	2.7	15.3	24.9	-4.5	-4.1	-0.7	-5.0	-3.8	-3.9	-4.4	-3.1	-3.4	-3.8	-4.1	-3.6	-4.7
Whole body fat-free mass	2.7	15.3	23.1	-4.5	-3.9	-1.0	-4.8	-3.9	-3.9	-4.4	-3.2	-3.4	-3.9	-4.2	-3.9	-4.6
Leg fat-free mass (right)	2.7	14.6	19.6	-4.2	-3.7	-1.4	-4.4	-3.9	-3.8	-4.2	-3.4	-3.2	-3.8	-4.1	-4.3	-4.4
Leg predicted mass (right)	2.7	14.5	19.4	-4.2	-3.7	-1.4	-4.3	-3.8	-3.8	-4.2	-3.4	-3.1	-3.8	-4.0	-4.3	-4.4
Ever had hysterectomy (womb removed)	2.6	3.0	6.2	1.9	0.8	0.5	2.4	1.5	1.7	1.4	2.5	2.2	1.8	1.6	1.2	1.6
Leg predicted mass (left)	2.6	13.5	18.6	-4.2	-3.3	-1.4	-4.3	-3.7	-3.7	-3.9	-3.4	-3.2	-3.6	-3.9	-4.2	-4.1
Trunk predicted mass	2.6	14.8	23.9	-4.5	-4.0	-0.7	-4.9	-3.7	-3.8	-4.3	-3.0	-3.4	-3.8	-4.1	-3.6	-4.5
Illnesses of father: Heart disease	2.6	3.6	7.4	2.7	1.9	1.4	2.5	2.0	2.0	2.2	1.2	0.8	1.7	1.6	2.0	1.7
Whole body water mass	2.6	14.7	22.4	-4.4	-3.8	-1.0	-4.7	-3.8	-3.8	-4.3	-3.1	-3.4	-3.8	-4.0	-3.9	-4.5
Number of operations (self-reported)	2.6	3.9	6.2	-1.7	-2.1	-1.9	-1.9	-2.0	-2.1	-2.5	-0.7	-1.8	-2.4	-2.1	-1.6	-2.1
Leg fat-free mass (left)	2.5	13.2	18.3	-4.2	-3.3	-1.4	-4.3	-3.6	-3.7	-3.9	-3.3	-3.1	-3.6	-3.8	-4.2	-4.1
Average weekly fortified wine intake	2.5	3.0	6.6	1.8	1.6	1.0	2.4	1.3	1.4	1.9	0.7	2.6	2.0	1.6	1.8	1.5
Medication: Levothyroxine sodium	2.5	4.3	7.6	-2.2	-2.2	-0.9	-1.3	-2.8	-2.6	-2.2	-2.5	0.4	-1.9	-1.9	-1.9	-2.5
Health satisfaction	2.5	3.3	7.5	-2.3	-1.3	0.0	-2.3	-1.4	-1.7	-1.8	-0.9	-1.6	-2.0	-2.1	-2.7	-1.6
Unable to work because of sickness or disability	2.5	3.2	5.7	-2.4	-2.0	-1.4	-1.9	-1.6	-1.7	-1.9	-0.7	-2.1	-2.0	-1.8	-1.6	-1.8
Commuting to job workplace: Walk	2.4	2.6	4.6	-2.0	-1.7	-0.3	-2.1	-1.5	-1.5	-1.8	-1.4	-1.5	-1.9	-1.8	-1.2	-1.3
Basal metabolic rate	2.4	13.2	19.7	-4.2	-3.6	-1.1	-4.4	-3.5	-3.6	-4.1	-3.0	-3.2	-3.5	-3.8	-3.7	-4.2
Had other major operations	2.3	2.8	5.5	-1.3	-1.7	-0.4	-2.0	-1.1	-1.2	-2.1	-0.5	-1.7	-2.1	-2.2	-2.4	-1.8
Financial difficulties in last 2 years	2.3	3.1	5.2	-1.9	-2.3	-0.2	-2.3	-1.7	-1.9	-2.1	-0.4	-0.7	-1.6	-2.0	-2.0	-2.1
Pulse rate	2.3	4.0	5.7	-2.1	-2.4	-1.5	-1.8	-2.1	-2.2	-2.2	-1.1	-1.9	-1.9	-1.7	-2.3	-2.3
Pulse wave Arterial Stiffness index	2.3	2.7	4.1	-1.5	-1.7	0.5	-1.6	-1.9	-1.9	-1.7	-2.0	-0.7	-1.6	-1.8	-1.9	-1.6
Medication: Seretide 50 evohaler	2.3	2.6	4.6	-2.0	-1.6	-0.7	-2.0	-1.5	-1.5	-2.1	-0.8	-1.7	-1.8	-1.8	-1.1	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	5.3	-1.2	-1.5	-0.8	-1.4	-1.4	-1.3	-2.3	-1.7	-2.1	-2.2	-1.9	-0.5	-2.2
Family relationship satisfaction	2.3	2.8	6.1	1.9	1.0	1.8	1.7	1.7	1.5	1.3	1.8	2.5	1.7	1.3	1.9	1.2
Osteoporosis (self-reported)	2.3	2.8	4.2	1.9	1.5	0.3	1.8	2.0	1.9	1.6	2.0	0.8	1.7	1.8	2.1	1.4
Wears glasses or contact lenses	2.3	2.7	5.1	-1.4	-1.9	-1.2	-1.8	-1.6	-1.5	-1.9	-0.9	-1.8	-1.3	-2.3	-1.0	-2.0
Arm fat-free mass (left)	2.3	11.7	17.4	-3.9	-3.8	-0.7	-4.2	-3.3	-3.4	-4.0	-2.5	-2.8	-3.4	-3.7	-3.3	-4.1
Medication: Lansoprazole	2.2	2.5	4.9	1.0	0.9	0.5	2.0	1.6	1.7	1.6	1.0	1.9	1.6	1.8	2.2	1.8
Pulse wave peak to peak time	2.2	2.6	3.9	1.5	1.7	-0.3	1.5	1.9	1.9	1.7	1.9	0.7	1.6	1.8	2.0	1.6
Shortness of breath walking on level ground	2.2	2.6	5.4	-1.5	-1.3	-0.8	-1.7	-1.2	-1.3	-1.9	-0.8	-1.8	-2.3	-1.7	-2.1	-1.6
Comparative height size at age 10	2.2	11.9	20.6	-3.8	-4.2	-1.1	-4.5	-3.5	-3.6	-4.0	-2.2	-2.6	-3.4	-3.9	-2.9	-3.7
Arm predicted mass (left)	2.2	11.2	16.7	-3.9	-3.7	-0.8	-4.1	-3.2	-3.3	-3.9	-2.4	-2.9	-3.3	-3.6	-3.2	-4.0
Mouth/teeth dental problems	2.1	3.3	6.9	2.5	1.7	-1.0	2.6	1.5	1.6	2.0	0.6	1.2	2.3	1.7	2.1	1.4
HbA1C	2.0	2.2	5.2	1.8	1.2	-0.1	2.3	1.3	1.3	1.6	1.4	1.6	1.4	1.6	0.6	1.7
Allergy or Eczema	2.0	5.2	8.9	-2.2	-2.9	-1.0	-2.2	-2.7	-2.7	-3.0	-1.2	-1.8	-2.6	-2.8	-1.3	-2.2
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.1	1.4	2.3	0.5	2.0	1.3	1.3	1.8	1.3	1.4	1.1	1.5	0.8	1.3
Breastfed as a baby	2.0	2.5	4.0	1.7	1.8	0.1	1.5	1.7	1.7	1.9	1.0	1.3	1.9	1.8	2.0	1.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	4.7	-1.7	-2.2	0.3	-1.7	-1.6	-1.8	-1.4	-1.7	-0.6	-1.6	-1.2	-1.9	-1.9
Arm fat-free mass (right)	1.9	9.5	15.3	-3.5	-3.4	-0.4	-3.9	-2.9	-3.0	-3.6	-2.5	-2.6	-2.9	-3.3	-2.9	-3.6
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.3	4.5	2.1	1.2	1.0	2.0	1.6	1.7	1.8	1.0	1.4	1.6	1.4	1.4	0.7
Age at first live birth	1.9	3.3	7.0	2.7	1.5	0.3	2.3	1.5	1.5	2.2	1.1	1.9	2.3	2.3	1.1	1.7
Age at last live birth	1.9	2.8	5.1	2.2	1.2	1.6	1.6	1.7	1.7	1.8	1.1	2.0	1.6	1.6	1.8	1.4
Back pain experienced in last month	1.9	2.7	5.4	-2.3	-2.3	-2.3	-1.3	-1.8	-1.9	-2.0	0.3	-1.3	-1.4	-1.4	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	7.0	2.4	2.6	-0.7	2.4	1.9	1.8	2.3	1.4	0.7	2.3	2.4	1.8	2.2
Alcohol usually taken with meals	1.8	2.9	7.4	1.6	1.1	0.0	1.7	1.2	1.5	1.6	1.8	2.7	1.9	1.5	2.3	1.6
Arm predicted mass (right)	1.8	9.4	14.7	-3.5	-3.3	-0.4	-3.8	-2.9	-2.9	-3.6	-2.4	-2.6	-3.0	-3.3	-3.0	-3.6
Suffer from ‘nerves’	1.8	2.8	4.5	1.9	1.8	0.7	2.1	1.4	1.4	1.8	1.5	2.0	1.8	2.0	1.2	1.5
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	6.1	2.1	2.5	0.5	1.7	1.4	1.6	1.7	0.7	0.9	1.3	1.5	0.8	1.4
Ever taken oral contraceptive pill	1.7	1.9	3.8	-1.7	-1.1	-0.3	-1.9	-1.3	-1.4	-1.5	-1.1	-0.6	-1.8	-1.3	-1.8	-1.2
Chronic bronchitis/emphysema (father)	1.6	1.9	5.1	-2.2	-1.4	-1.1	-1.9	-1.5	-1.7	-1.3	-1.1	-1.0	-0.9	-1.0	-1.1	-1.1
Length of working week for main job	1.5	1.6	3.3	0.8	1.2	1.8	0.7	1.3	1.5	1.0	1.1	1.6	1.2	1.1	1.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.5	1.0	1.1	1.3	1.4	1.4	1.4	1.1	1.3	1.4	1.0	1.5	1.9	1.0
Osteoarthritis (self-reported)	1.5	1.9	2.7	-1.4	-1.4	-0.8	-1.4	-1.5	-1.6	-1.6	-0.5	-1.6	-1.5	-1.4	-1.6	-1.2
Medication: Aspirin	1.5	1.9	5.1	1.7	0.6	0.6	2.2	1.1	1.0	1.3	0.9	2.3	1.6	1.3	1.6	1.0
Cholesterol lowering medication	1.5	2.2	3.2	-1.5	-1.6	-0.2	-1.8	-1.2	-1.3	-1.8	-1.4	-1.5	-1.7	-1.7	-1.7	-1.4
Lung FVC	1.4	6.9	10.6	2.4	2.9	0.9	2.5	2.6	2.5	2.7	3.2	2.7	2.5	2.5	2.9	3.0
Hair/balding pattern: Pattern 4	1.4	3.4	10.5	-1.2	-3.2	-0.1	-2.1	-1.6	-1.7	-2.1	-1.5	-1.4	-1.2	-1.9	-1.4	-2.5
Financial situation satisfaction	1.4	1.8	4.2	-2.0	-1.4	1.0	-1.9	-0.9	-1.2	-1.5	-0.2	-0.7	-1.3	-1.4	-1.8	-0.8
Medication: Lisinopril	1.4	1.8	6.4	1.4	0.3	1.6	1.1	1.6	1.7	1.0	2.5	0.6	1.2	1.2	0.6	1.3
Schizophrenia (2014)	1.3	3.0	5.6	-1.7	-2.3	-0.7	-2.4	-1.5	-1.5	-2.2	-0.6	-2.0	-1.7	-2.1	-1.2	-1.3
Height	1.3	24.4	42.5	-6.5	-5.4	1.7	-6.1	-4.7	-4.6	-5.6	-4.1	-3.2	-5.0	-5.4	-4.0	-5.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.5	-1.6	-1.5	-0.7	-1.3	-1.1	-0.9	-1.4	-1.2	-1.9	-1.4	-1.0	-1.6	-0.9
Number of live births	1.3	1.8	4.1	-1.2	-1.0	0.7	-2.0	-0.3	-0.6	-1.5	-0.6	-1.8	-1.8	-1.8	-1.6	-1.1
Standing height	1.3	12.5	18.3	-4.3	-4.0	-0.1	-4.2	-3.6	-3.5	-4.2	-2.9	-2.1	-3.5	-4.0	-3.0	-4.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	6.0	1.1	1.1	-0.4	1.4	0.5	0.2	0.9	0.8	2.4	0.9	1.2	1.8	1.4
Pulse rate, automated reading	1.3	4.1	9.0	-2.6	-2.0	-1.2	-2.5	-1.5	-1.6	-2.1	-0.8	-3.0	-2.3	-1.7	-2.1	-1.8
Lupus	1.2	1.8	5.5	-1.2	-2.4	0.2	-1.3	-1.1	-1.2	-1.7	-0.2	-0.7	-1.1	-1.8	-1.5	-1.6
Blood Eosinophil Count	1.2	8.9	14.6	-2.7	-2.8	2.0	-3.4	-3.1	-3.4	-3.4	-2.9	-2.2	-2.8	-3.1	-2.8	-3.8
Severe depression (siblings)	1.2	1.4	3.3	-0.8	-0.4	-1.8	-1.0	-1.6	-1.7	-0.9	-0.9	-1.4	-1.0	-0.9	-1.0	-1.0
Medication: Paracetamol	1.2	2.0	3.0	-1.4	-1.2	-0.8	-1.4	-1.6	-1.4	-1.7	-1.6	-1.0	-1.4	-1.7	-1.6	-1.5
Number of full brothers	1.2	1.5	2.6	-1.5	-1.1	-1.6	-0.8	-1.6	-1.5	-1.2	-1.5	-0.8	-1.2	-1.0	-0.9	-0.7
Had major operations	1.2	1.4	4.1	-0.8	-1.4	-1.4	-0.0	-1.6	-1.8	-0.9	-2.0	0.2	-0.6	-0.7	0.1	-1.2
Supplements: Vitamin C	1.2	1.4	3.2	1.3	0.8	1.8	1.6	1.1	0.9	1.3	0.3	1.1	0.9	1.3	0.8	1.3
Medication: Blood pressure	1.2	2.4	4.0	1.6	1.5	1.5	1.6	2.0	1.9	1.4	1.4	0.8	1.7	1.6	1.2	1.6
Respiratory disease	1.1	2.5	5.2	-1.6	-1.9	0.4	-2.1	-1.3	-1.3	-2.3	-0.3	-1.6	-1.5	-2.0	-0.9	-1.9
Weight	1.1	5.6	8.5	-2.9	-2.4	-1.4	-2.8	-2.1	-2.2	-2.7	-1.6	-2.3	-2.2	-2.5	-2.5	-2.7
Birth weight of first child	1.1	2.0	4.2	-1.4	-2.1	0.6	-1.5	-1.4	-1.6	-1.7	-1.1	-0.5	-1.3	-1.4	-1.7	-1.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.3	-1.8	-1.3	1.5	-1.7	-0.5	-0.7	-1.0	-0.3	-0.7	-1.5	-1.0	-0.6	-0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.7	0.9	1.4	-0.7	1.4	1.3	1.0	1.2	1.2	0.8	0.7	1.6	0.9	1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.6	-0.5	-2.1	-0.5	-0.2	-1.3	-1.2	-1.4	-1.5	-0.9	-0.8	-1.5	-1.1	-1.3
Systolic blood pressure, automated reading	1.0	2.8	4.0	1.9	1.9	0.8	1.8	2.0	2.0	1.9	1.6	0.2	1.7	1.6	1.8	1.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.9	0.9	1.3	-0.5	1.2	1.0	0.7	1.2	0.6	1.4	0.9	1.3	0.4	1.3
Mouth/teeth dental problems: Dentures	1.0	1.6	6.1	0.0	1.1	2.5	0.0	1.4	1.4	0.9	2.3	0.4	0.3	0.9	0.4	1.5
Neck or shoulder pain in last month	1.0	1.4	3.2	-1.4	-1.1	-0.3	-1.8	-0.9	-1.1	-1.4	0.0	-1.5	-1.4	-1.1	-1.4	-0.9
Crohns Disease (2012)	0.9	1.5	4.7	-1.7	-1.2	-2.2	-1.1	-1.1	-1.3	-1.5	-0.0	-0.9	-1.0	-1.3	-0.5	-0.9
Chronotype (morning person)	0.9	2.1	5.7	-0.4	-0.9	-2.1	-1.4	-1.1	-0.9	-1.2	-1.1	-2.4	-1.3	-1.6	-1.8	-1.6
Angina	0.9	1.2	1.9	1.4	1.3	0.2	1.2	1.2	1.1	1.1	0.7	1.0	1.0	1.4	1.0	1.1
Fed-up feelings	0.9	1.7	4.8	0.8	2.0	1.1	0.9	1.2	1.1	0.9	2.2	0.8	1.6	1.1	1.5	0.9
Medication: Cholesterol lowering	0.9	1.4	3.2	1.5	0.4	0.4	1.8	1.2	1.1	1.3	1.0	1.4	1.4	1.2	1.0	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.6	-0.9	-0.8	-1.9	-0.9	-0.9	-0.9	-1.1	-1.4	-1.8	-0.9	-1.1	-0.7	-1.1
Wheeze or whistling in the chest in last year	0.9	1.7	4.0	-2.0	-1.1	0.6	-1.7	-1.2	-1.2	-1.6	0.3	-0.8	-2.0	-1.4	-0.3	-1.0
Angina (self-reported)	0.9	1.2	2.0	1.3	1.4	0.2	1.2	1.1	1.0	1.1	0.6	1.1	0.9	1.4	1.0	1.1
Illnesses of siblings: Diabetes	0.9	1.1	3.4	-1.3	-1.9	1.0	-1.0	-0.8	-0.6	-1.1	-0.7	0.2	-0.3	-1.0	-1.0	-1.6
Mineral and other dietary supplements	0.9	1.3	2.2	0.3	1.4	0.8	0.4	1.3	1.1	1.3	1.4	1.3	0.9	1.5	1.0	1.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.2	-1.2	-1.4	-0.5	-0.8	-1.0	-1.1	-1.3	0.2	-0.5	-1.0	-0.9	-1.8	-1.0
Neuroticism (Nagel 2018)	0.8	1.9	3.3	1.4	1.6	0.4	1.8	1.2	1.0	1.1	1.7	1.3	1.5	1.4	1.6	1.4
LDL Cholesterol	0.8	1.2	3.1	-0.7	-0.8	-1.8	-0.4	-1.5	-1.4	-1.2	-0.9	0.2	-1.1	-1.1	-0.9	-1.2
Systolic Blood Pressure	0.8	3.9	6.4	2.5	2.5	0.4	2.2	2.0	2.0	2.5	1.6	0.4	2.3	2.2	1.8	1.8
Neuroticism	0.8	2.0	4.2	1.6	2.0	0.5	1.8	1.2	1.2	1.6	1.1	0.7	1.5	1.4	1.8	1.3
Impedance of leg (right)	0.8	3.7	6.4	1.9	1.8	0.7	2.1	1.9	1.7	2.1	1.7	1.6	1.9	2.1	2.5	2.3
Townsend deprivation index at recruitment	0.8	1.1	2.2	-1.4	-0.5	-0.5	-1.4	-0.9	-1.0	-1.1	-0.5	-0.6	-1.3	-1.1	-1.1	-1.5
Sitting height	0.8	5.7	9.9	-3.1	-2.4	-1.4	-3.0	-2.6	-2.6	-2.7	-1.7	-1.9	-2.3	-2.4	-1.7	-2.6
Impedance of leg (left)	0.8	3.8	7.8	2.0	1.3	0.5	2.3	1.8	1.8	1.8	2.1	1.8	1.9	2.0	2.8	2.1
Illnesses of siblings	0.8	1.2	3.9	-0.9	-0.4	-2.0	-0.2	-1.6	-1.4	-0.9	-1.1	-0.4	-1.2	-0.6	-0.5	-1.3
Hair/balding pattern: Pattern 3	0.8	1.2	4.8	0.8	1.1	1.6	1.3	0.5	0.9	1.0	0.5	2.2	0.4	0.5	0.9	0.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.8	-1.6	-1.0	0.0	-0.8	-1.7	-1.6	-1.4	-1.6	0.3	-1.1	-1.1	-1.1	-1.5
Mean time to correctly identify matches	0.8	1.5	3.8	-1.1	-1.3	-0.6	-1.1	-1.1	-1.1	-1.5	-0.5	-0.9	-0.8	-1.6	-1.9	-1.7
Medication: Aspirin	0.8	1.1	3.7	1.0	0.1	0.3	1.7	0.6	0.5	0.8	0.9	1.9	1.2	0.8	1.3	0.5
Mood swings	0.8	1.4	3.6	1.4	0.6	-0.3	1.8	0.9	0.7	0.8	1.5	0.8	1.9	1.0	1.8	0.5
Qualifications: nursing, teaching	0.8	1.3	2.5	1.5	1.5	0.4	1.1	1.0	1.1	1.4	0.5	0.8	0.9	1.2	1.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.4	-1.6	-1.4	0.4	-1.2	-0.5	-0.7	-1.3	0.7	-0.9	-1.1	-0.5	-0.6	-0.5
Mother’s age at death	0.8	1.1	3.7	-1.0	-1.5	-0.9	-1.2	-0.5	-0.6	-0.7	-0.6	-1.9	-1.0	-1.1	-0.8	-0.6
Impedance of whole body	0.8	4.0	6.2	2.2	1.7	0.6	2.5	1.9	1.9	1.9	1.8	2.2	1.9	1.9	2.5	2.3
Heel T-Score	0.7	5.5	9.1	2.4	2.5	0.2	2.6	2.3	2.5	2.7	2.0	1.6	2.3	2.6	3.0	2.5
Average weekly spirits intake	0.7	0.9	1.8	-1.1	-0.5	-0.2	-1.1	-1.1	-1.0	-1.2	-0.5	-0.6	-1.1	-1.0	-1.0	-1.3
Waist circumference	0.7	2.4	3.8	-1.9	-1.7	-1.3	-1.8	-1.2	-1.5	-1.7	-1.0	-1.9	-1.2	-1.6	-1.4	-1.6
Glaucoma (self-reported)	0.7	0.9	2.4	0.6	1.0	0.5	0.8	1.5	1.4	0.7	1.5	0.6	0.7	0.6	-0.3	0.8
Number of children fathered	0.7	0.8	2.7	-0.8	-1.6	-0.6	-1.0	-1.0	-1.0	-1.1	0.1	-0.6	-0.6	-1.0	0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	6.8	-0.5	-0.1	-2.6	0.3	-1.0	-1.1	-0.4	-0.2	-0.7	-0.7	-0.0	-1.0	-0.3
Knee pain experienced in last month	0.7	1.1	2.8	-0.6	-1.0	1.0	-0.5	-1.0	-0.8	-1.7	-0.2	0.3	-1.2	-1.6	-0.9	-1.4
Illnesses of father: High blood pressure	0.7	0.9	4.0	0.9	0.5	2.0	0.2	1.3	1.2	0.7	0.9	0.4	-0.0	0.7	-0.3	1.2
Ever depressed for a whole week	0.7	0.8	2.9	0.3	-1.2	0.2	-1.2	-0.1	-0.1	-1.0	0.2	-1.7	-0.7	-1.3	-1.2	-0.5
Schizophrenia vs Biploar Disorder	0.6	0.7	5.2	-0.5	-0.1	2.3	-1.1	-0.3	-0.1	-1.0	0.3	-0.0	-0.8	-0.7	-0.4	-0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.7	1.5	0.7	1.9	0.8	1.5	1.6	1.5	0.6	0.5	1.2	1.1	0.7	1.4
Ulcerative Colitis	0.6	0.9	3.1	-0.7	-0.5	-1.6	-1.1	-0.5	-0.7	-0.5	-0.6	-1.8	-0.8	-0.6	-1.3	-0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.7	3.3	-0.2	-1.2	1.8	-1.1	0.2	0.2	-0.5	1.2	-0.5	-0.8	-0.7	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.7	0.9	0.8	-0.1	1.2	1.1	1.1	1.4	1.5	0.5	1.1	1.6	1.5	1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	4.4	-0.4	-2.1	-1.1	-0.5	-0.3	-0.5	-1.1	0.9	-0.4	-0.2	-0.6	0.3	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	2.8	0.2	1.7	0.9	1.2	0.7	0.6	1.4	-0.3	0.5	1.1	1.2	1.1	1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	1.5	0.7	0.9	0.7	1.2	1.2	0.7	0.1	0.1	0.8	0.2	0.4	0.9
Pain all over the body in last month	0.6	0.6	3.1	-0.4	-0.3	-0.3	-0.7	-0.5	-0.4	-0.7	-0.3	-0.9	-1.0	-1.2	-1.8	-0.5
Hip circumference	0.6	2.7	3.5	-1.8	-1.4	-1.5	-1.8	-1.3	-1.4	-1.8	-1.6	-1.7	-1.6	-1.8	-1.9	-1.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.5	1.3	1.6	1.0	1.4	0.9	1.1	1.4	0.1	1.0	1.2	1.2	1.5	1.0
Impedance of arm (left)	0.6	2.8	4.4	1.9	1.7	0.3	2.1	1.7	1.7	1.8	1.1	1.7	1.7	1.6	1.6	2.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.9	-1.4	-0.5	-0.2	-1.2	-1.3	-1.1	-1.1	-1.2	-1.0	-1.3	-1.0	-0.6	-0.5
Medication: Amlodipine	0.6	0.8	4.4	0.5	0.5	2.1	0.4	0.9	1.2	0.8	0.7	1.3	0.5	0.7	-0.0	0.3
Worry too long after embarrassment	0.6	1.0	2.1	1.3	0.9	1.1	1.5	0.8	0.8	1.0	-0.2	0.7	1.1	1.2	0.6	0.8
Medication: Blood pressure	0.6	1.1	1.9	1.1	0.6	0.6	1.0	1.4	1.3	1.3	1.4	1.0	1.0	1.2	0.3	0.6
Friendships satisfaction	0.6	0.8	4.3	-0.7	0.1	2.1	-0.6	-0.6	-0.7	-0.6	-1.5	0.3	-0.7	-0.5	-0.8	-0.4
Number of self-reported non-cancer illnesses	0.6	1.0	2.2	-0.7	-1.3	-0.8	-1.0	-0.7	-0.8	-1.5	0.8	-0.8	-0.7	-1.3	-0.4	-1.3
Hearing aid user	0.6	0.6	1.4	-0.8	-1.0	-0.8	0.0	-1.0	-1.2	-0.9	-0.6	-0.3	-0.6	-0.6	-0.8	-1.0
Medication: Atorvastatin	0.6	0.7	3.7	0.0	-0.1	1.2	1.1	0.5	0.3	0.5	1.1	1.9	0.4	0.7	0.5	0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	0.4	1.2	0.4	0.7	0.8	0.7	1.0	0.5	0.9	0.5	0.8	1.4	0.7
Bipolar Disorder (2018)	0.5	0.7	5.0	0.4	-0.7	-2.2	-0.3	-0.8	-0.7	-0.5	-1.0	-0.8	-0.1	-0.6	0.1	-0.6
Depressed Affect (Nagel 2018)	0.5	1.0	3.9	0.7	1.0	1.0	0.7	0.8	0.7	0.5	2.0	0.8	1.3	0.4	1.3	0.7
Major Depression (MDD)	0.5	0.6	1.6	1.3	0.7	-0.8	0.1	1.0	0.6	0.9	0.4	0.0	0.9	1.1	0.0	0.9
Reaction Time	0.5	0.9	3.5	-0.8	-0.6	-0.6	-1.0	-0.6	-0.7	-1.0	-0.9	-0.7	-0.3	-0.9	-1.9	-1.3
Coronary Artery Disease (CAD)	0.5	0.6	3.1	0.7	0.9	1.8	0.2	0.8	0.9	0.9	0.2	-0.1	0.5	0.8	0.6	0.6
BMI	0.5	2.8	6.6	-1.6	-1.2	-1.8	-1.6	-1.1	-1.2	-1.8	-1.0	-2.6	-1.7	-1.7	-2.3	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	1.8	0.9	1.0	0.3	1.0	1.1	1.0	1.2	1.3	0.1	0.7	1.4	0.9	1.3
Depression (self-reported)	0.5	0.6	1.2	-0.5	-0.2	-1.0	-0.8	-1.0	-1.1	-0.8	-0.7	-0.5	-0.7	-0.8	-0.7	-0.8
Illnesses of mother	0.5	0.6	1.2	-1.1	-0.5	0.5	-0.0	-1.0	-0.7	-0.7	-0.6	0.2	-1.1	-0.9	-1.0	-0.6
Loud music exposure frequency	0.5	0.5	1.7	0.8	0.1	0.8	0.9	0.2	0.0	0.2	-0.5	1.1	1.0	0.5	1.3	-0.1
Eye problems/disorders: None of the above	0.5	0.5	1.2	-1.0	-0.4	-0.1	-1.1	-0.8	-0.8	-0.9	0.2	-1.0	-0.8	-0.7	-0.4	-0.5
Alcohol intake frequency.	0.5	1.3	12.2	-0.2	1.1	-3.5	-0.2	-0.2	-0.3	-0.6	0.3	-1.4	-0.5	-0.2	0.2	0.0
Ever had bowel cancer screening	0.5	0.6	1.8	-0.7	-0.7	-0.1	-0.7	-0.8	-0.7	-1.3	-0.3	-0.7	-0.9	-1.1	0.0	-0.8
Eye problems/disorders: Cataract	0.5	0.5	1.7	1.3	1.0	0.0	0.8	0.8	0.7	0.9	-0.3	0.2	0.8	0.9	0.4	0.3
Diastolic blood pressure, automated reading	0.5	1.7	3.6	1.3	1.5	1.0	1.0	1.8	1.9	1.4	1.3	-0.3	1.3	1.3	1.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.9	0.6	0.4	-0.5	1.4	0.1	0.3	0.5	0.9	1.2	1.0	0.6	0.9	0.0
Pack years of smoking	0.5	0.8	2.2	0.7	-0.5	0.9	0.3	0.7	0.5	0.4	1.5	1.4	0.8	1.0	0.9	1.0
Bipolar Disorder or Schizophrenia	0.4	1.1	2.6	-0.1	-1.6	-1.0	-1.4	-0.8	-0.7	-1.2	-0.5	-1.3	-0.6	-1.3	-0.5	-1.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.9	1.7	0.9	0.4	1.1	1.2	1.4	1.4	-0.4	0.4	1.3	1.0	0.9	1.3
Schizophrenia (2018)	0.4	0.9	2.5	-0.5	-1.5	0.6	-1.6	-0.3	-0.4	-1.2	0.3	-1.0	-0.7	-1.2	-0.7	-0.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	-0.6	-0.8	-1.1	-1.0	-0.4	-0.5	-0.7	-0.6	-1.3	-0.5	-0.7	-0.3	-0.3
Primary Biliary Cirrhosis	0.4	0.6	2.5	-1.0	-0.5	-0.5	-1.3	0.2	0.0	-0.8	0.5	-1.6	-0.9	-0.5	0.1	-0.6
Medication for hormone replacement therapy	0.4	0.4	1.4	0.3	-0.6	1.2	-0.1	0.9	0.8	0.6	0.3	1.0	0.3	0.4	-0.1	0.8
Maternal smoking around birth	0.4	0.5	3.4	0.0	-0.2	1.8	0.0	-0.4	-0.4	-0.4	-0.5	1.3	-0.7	0.0	0.5	-0.2
Relative age voice broke	0.4	0.6	1.3	0.9	0.9	-0.5	0.9	0.7	0.8	1.1	0.0	-0.5	1.1	0.9	0.5	0.5
Taking other prescription medications	0.4	0.6	2.5	-0.3	-1.1	1.6	-0.6	0.2	-0.0	-0.9	1.4	-0.4	-0.2	-0.7	-0.2	-0.5
Multivitamins +/- minerals	0.4	0.5	2.5	-0.5	-0.3	1.6	-0.7	-0.4	-0.3	-0.6	-0.2	-0.6	-0.7	-0.8	-0.8	-0.6
Past tobacco smoking	0.4	0.6	1.6	0.8	1.2	-1.3	0.8	0.2	0.2	1.0	-0.6	-0.3	0.8	1.0	0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	-1.1	-0.4	1.1	-0.6	-0.8	-0.9	-0.7	0.2	-0.0	-1.0	-0.8	-0.3	-1.2
Had menopause	0.4	0.4	2.2	-0.2	-1.5	0.1	-0.6	-0.1	-0.2	-0.9	0.3	-0.1	-0.6	-1.2	-0.0	-0.7
Impedance of arm (right)	0.4	1.9	2.5	1.5	1.2	0.3	1.6	1.4	1.5	1.5	1.4	1.5	1.4	1.3	1.2	1.6
Lung cancer (father)	0.4	0.5	1.4	-0.4	-1.2	1.2	0.2	-0.2	-0.2	-0.2	0.7	1.1	-0.4	-0.1	1.1	-0.3
Heart disease (mother)	0.4	0.5	1.4	0.5	-0.0	0.9	0.2	0.8	0.7	0.2	1.2	0.1	0.8	0.2	1.1	0.8
Overall health rating	0.4	0.9	2.4	-1.6	-0.3	-1.3	-1.2	-0.7	-0.8	-0.9	0.7	-0.8	-0.8	-0.8	-1.1	-0.7
Asthma (self-reported)	0.4	0.8	2.0	-0.8	-1.0	0.3	-1.2	-0.7	-0.8	-1.4	0.5	-1.0	-0.6	-1.0	-0.1	-1.1
Commuting to job workplace: Public transport	0.4	0.4	1.2	0.8	1.0	1.1	0.8	0.8	1.0	0.3	-0.1	0.3	0.3	0.3	0.2	0.3
Alcohol drinker status: Never	0.4	0.4	2.1	0.4	1.2	-1.4	0.3	0.0	-0.1	0.4	-0.0	-0.4	0.2	0.7	1.0	0.1
Ever smoked	0.4	0.7	5.4	-0.2	-0.3	2.3	-0.3	0.8	0.8	-0.2	1.3	0.6	-0.2	-0.2	-0.1	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.1	1.0	1.0	0.4	0.8	0.6	0.5	0.6	-0.1	0.9	0.5	0.9	-0.1	0.7
Worry (Nagel 2018)	0.3	0.6	2.7	0.8	0.9	-1.7	1.1	0.3	0.2	0.7	0.4	-0.3	0.6	0.8	0.4	0.5
Irritable Bowel Disease (IBD)	0.3	0.7	3.8	0.1	1.0	-1.9	0.0	0.6	0.4	0.6	1.0	-0.7	0.4	0.6	0.1	0.9
Ulcerative Colitis (UC)	0.3	0.6	3.6	0.0	1.1	-1.9	-0.3	0.4	0.2	0.5	0.2	-1.4	0.0	0.4	-0.8	0.2
Mean Putamen Volume	0.3	0.3	0.9	-0.6	-0.9	-0.6	-0.6	-0.1	-0.2	-0.9	-0.4	-0.8	-0.2	-0.6	-0.2	-0.7
Fasting Glucose	0.3	0.4	2.9	-0.1	-0.3	-1.7	0.3	-0.2	-0.1	-0.3	0.1	-0.7	-0.4	-0.4	-0.1	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.9	-1.4	-0.7	-0.9	-0.1	-0.4	0.1	-0.3	-0.5	-0.3	0.0	-0.4	0.8	-0.1
Smoking Status	0.3	0.7	1.7	-1.3	-1.0	0.7	-0.6	-0.8	-0.8	-0.9	-0.8	0.6	-1.0	-0.9	-1.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.1	-1.0	0.5	-0.9	-0.2	-0.7	-0.7	0.0	-0.8	-0.5	-0.5	-0.1	-1.4	-0.5
Number of treatments/medications taken	0.3	0.5	1.4	0.8	-0.2	0.4	0.8	0.9	0.9	0.1	1.2	0.6	1.2	0.4	0.5	0.3
Medication: Metformin	0.3	0.5	1.7	-1.3	-0.4	-0.2	-1.0	-0.2	-0.6	-0.5	0.2	-0.9	-0.6	-0.4	-1.0	-0.1
Diabetes (mother)	0.3	0.3	1.1	0.2	0.8	-0.4	0.2	0.7	0.5	0.6	0.8	-0.1	1.1	0.4	0.6	0.0
Current tobacco smoking	0.3	0.4	1.7	-1.3	-0.8	0.3	-0.9	-0.6	-0.8	-0.6	-0.2	0.0	-0.5	-0.4	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	-0.6	-1.1	-0.1	-0.5	-0.4	-0.5	-0.4	0.3	0.5	-0.2	-0.3	-0.8	-0.4
Heart attack	0.3	0.3	0.9	-0.8	-0.4	1.0	-0.5	-0.0	-0.3	-0.3	-0.5	-0.0	-0.4	-0.6	-0.9	-0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	0.1	-1.1	-0.7	-0.6	-0.7	-0.7	-0.9	0.0	-0.5	-0.3	-0.7	0.1	-0.8
Medication: Simvastatin	0.3	0.5	1.6	-0.2	-1.0	-0.9	-0.3	-0.2	-0.3	-0.6	-0.8	-0.7	-0.1	-0.6	-0.6	-1.3
Fluid intelligence score	0.3	0.6	2.1	0.9	0.3	1.4	-0.1	1.2	1.1	0.8	0.1	-0.8	0.8	0.4	-0.0	0.7
Worrier / anxious feelings	0.3	0.5	2.1	0.2	-0.5	-1.4	0.0	-0.7	-0.7	-0.4	-1.1	-0.9	-0.1	-0.5	-0.6	-0.8
Noisy workplace	0.3	0.3	0.9	-0.3	-0.9	-0.1	0.0	-0.8	-0.9	-0.4	-0.1	0.6	-0.5	-0.5	0.3	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	0.0	-1.0	0.7	0.0	0.4	0.4	0.3	-0.3	0.9	0.5	0.4	0.7	0.7
Asthma	0.3	0.6	1.7	-0.8	-0.9	0.2	-1.0	-0.7	-0.8	-1.3	0.4	-0.9	-0.5	-0.9	-0.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.5	-0.8	0.8	-0.3	-0.7	-0.9	-0.7	-0.8	0.2	-0.4	-0.7	-0.8	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.9	0.6	-0.2	-0.5	0.2	0.2	-0.1	-0.0	1.4	0.8	0.6	0.4	1.0	0.1
Blood clot in the leg (DVT)	0.3	0.4	1.5	0.5	0.3	-0.6	1.2	0.2	0.3	0.4	0.9	0.8	0.9	0.4	0.6	-0.1
Headache pain in last month	0.3	0.5	4.6	-0.1	2.1	0.2	-0.0	0.5	0.7	0.5	0.2	0.3	-0.2	0.4	0.6	0.6
Birth weight	0.3	0.7	2.0	-0.5	-0.0	0.5	-1.3	0.4	0.4	-0.9	1.0	-1.4	-1.1	-0.5	-0.9	-0.7
Exposure to tobacco smoke outside home	0.3	0.4	1.4	-0.7	-0.4	1.2	-0.6	-0.2	-0.3	-0.4	-1.1	-0.6	-0.5	-0.4	-0.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.5	0.5	-0.5	0.8	0.6	0.5	0.4	0.4	0.5	0.4	0.6	0.9	0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	2.1	-0.6	0.0	-0.8	-1.2	-0.5	-0.5	-0.3	-0.3	-1.5	-0.7	-0.3	-0.7	-0.5
Medication: Ibuprofen	0.3	0.4	0.7	-0.5	-0.8	0.5	-0.2	-0.7	-0.8	-0.8	-0.6	0.5	-0.3	-0.8	-0.7	-0.7
Chest pain or discomfort	0.3	0.4	1.3	-1.1	0.6	-0.1	-0.9	0.4	0.2	-0.2	1.2	-0.5	-0.5	0.4	-0.2	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	0.5	-0.0	0.2	0.8	0.2	0.1	0.4	0.9	1.1	1.0	0.5	0.7	0.4
Smoking status: Previous	0.3	0.4	1.0	-0.7	-0.9	0.6	-0.7	-0.4	-0.4	-0.8	-0.1	0.3	-0.6	-1.0	-0.5	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.2	-1.1	-0.5	0.5	-0.5	-0.7	-0.9	-0.5	-0.4	0.4	-0.2	-0.4	-0.9	-0.4
Medication for cholesterol	0.3	0.4	1.2	-0.3	0.0	-0.5	-0.3	-1.1	-1.0	-0.6	-0.6	0.1	-0.9	-0.6	-0.1	-0.6
Medication: Gliclazide	0.3	0.3	1.6	-0.5	-0.6	0.4	-0.1	0.1	-0.0	-0.8	1.2	0.1	-0.1	-0.6	-0.1	-0.7
Smoking status: Current	0.3	0.4	1.6	-1.3	-0.9	0.5	-0.9	-0.5	-0.7	-0.6	-0.1	0.1	-0.5	-0.4	-0.8	-0.2
Risk taking	0.3	0.4	2.6	-0.2	-0.6	1.6	0.0	-0.2	-0.1	-0.2	0.4	1.5	-0.0	-0.2	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.9	-0.4	1.0	-0.5	-0.1	-0.3	-0.4	-0.6	-0.2	-0.6	-0.6	-0.9	-0.9
Leg fat mass (left)	0.3	1.2	2.7	-1.6	-1.2	-1.1	-1.3	-0.7	-0.8	-1.2	-0.3	-1.6	-0.8	-0.9	-1.1	-0.9
Crohns Disease (2017)	0.2	0.5	2.6	-0.3	0.3	-1.6	0.1	0.3	0.0	0.1	1.0	0.1	0.6	0.4	1.1	0.8
Breast Cancer	0.2	0.4	1.4	1.2	0.4	0.5	0.2	1.0	1.1	0.6	0.1	-0.2	0.6	0.3	0.2	-0.1
HDL Cholesterol	0.2	0.3	1.8	-0.2	-0.8	1.4	-0.4	-0.2	-0.1	-0.4	0.2	-0.2	-0.7	-0.6	-0.8	-0.2
Neuroticism (2016)	0.2	0.3	1.0	0.5	0.3	-0.1	1.0	-0.1	-0.4	0.2	-0.3	1.0	0.2	0.3	0.8	0.0
Cardiovascular Disease	0.2	0.6	2.3	0.1	-0.6	-1.5	0.4	-0.4	-0.4	-0.3	-0.8	-0.9	-0.0	-0.4	-1.3	-1.0
Hypothyroidism (self reported)	0.2	0.4	2.1	-0.7	0.2	-0.6	0.1	-1.0	-1.0	-0.4	-1.4	0.3	-0.4	-0.0	-0.5	-0.3
Sensitivity / hurt feelings	0.2	0.4	1.5	0.1	0.8	-1.2	0.4	0.2	-0.1	0.1	0.4	-1.2	0.6	0.4	-0.1	0.4
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-0.6	1.0	-0.7	0.4	-0.0	-0.2	0.5	0.0	-0.6	0.3	0.5	0.4	0.5
Relative age of first facial hair	0.2	0.4	1.6	-0.1	-0.5	-0.3	0.2	-0.9	-0.7	-0.4	-1.3	-0.2	-0.3	-0.6	-0.4	-1.0
Pack years adult smoking proportion	0.2	0.3	1.3	0.2	-0.7	0.6	-0.2	0.3	0.1	0.0	1.2	1.0	0.3	0.6	0.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.1	-0.1	1.1	0.3	0.6	-0.1	-0.1	0.0	0.8	0.8	-0.2	-0.0	0.3	0.1
Age when periods started (menarche)	0.2	0.4	2.1	0.2	-0.2	1.5	0.3	0.7	0.9	0.3	0.4	1.0	0.4	0.4	-0.2	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	1.8	-0.8	-0.0	0.0	-0.6	-0.4	-0.5	0.4	-0.5	-0.5	-0.4	0.1	-1.4	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.9	-0.9	-0.8	-0.3	-0.3	-0.1	-0.1	-0.1	0.4	-0.0	0.2	0.5	0.6	0.2
High blood pressure (mother)	0.2	0.3	1.7	0.7	-0.0	-1.3	-0.1	0.1	-0.1	0.4	-0.2	-0.7	0.3	0.4	-0.1	0.1
Body mass index (BMI)	0.2	1.0	2.3	-1.2	-0.9	-1.4	-1.1	-0.6	-0.7	-1.0	-0.4	-1.5	-0.7	-0.8	-1.3	-0.9
Number of incorrect matches in round	0.2	0.3	2.3	-0.3	0.3	0.3	0.9	-0.1	0.0	0.0	0.2	1.5	-0.3	0.2	0.1	0.7
Nervous feelings	0.2	0.4	1.3	0.4	0.8	-1.1	0.8	0.3	0.1	0.8	-0.5	-0.9	0.3	0.5	-0.0	0.5
Qualifications: None of the above	0.2	0.4	1.8	0.6	0.1	0.2	-0.0	0.6	0.3	-0.3	1.2	0.9	0.6	0.2	1.4	0.1
Diabetes (self-reported)	0.2	0.2	1.3	-0.5	-0.3	-0.6	-0.2	-0.3	-0.5	-0.2	0.1	-0.6	0.1	-0.3	-1.2	-0.3
Medication: Ramipril	0.2	0.2	1.3	-0.8	-0.2	-1.2	-0.6	-0.0	-0.5	0.0	-0.0	-0.7	-0.2	0.1	-0.1	-0.2
Neuroticism score	0.2	0.5	1.3	0.8	1.1	-0.0	0.8	0.4	0.2	0.8	0.3	-0.1	1.1	0.9	0.8	0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.3	-0.3	0.5	-0.8	0.1	0.0	-0.4	0.3	-0.6	-0.5	-0.3	-1.0	-0.7
Father’s age at death	0.2	0.3	0.9	-0.6	0.4	0.3	-0.1	0.9	0.9	0.4	-0.1	0.0	-0.4	0.5	0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.1	0.1	0.8	0.1	0.1	0.3	0.1	0.4	1.4	1.2	0.2	0.4	0.5	0.4
Happiness	0.2	0.2	0.6	-0.3	0.1	0.7	-0.6	-0.4	-0.4	-0.6	-0.3	0.4	-0.3	-0.8	0.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	0.5	0.9	0.7	0.4	0.9	0.8	0.7	0.6	0.8	0.8	0.9	1.0	0.7
Arm fat mass (right)	0.2	0.9	2.2	-1.4	-1.0	-1.0	-1.2	-0.5	-0.6	-1.1	-0.0	-1.5	-0.6	-0.8	-1.0	-0.8
Exposure to tobacco smoke at home	0.2	0.3	2.0	-0.4	0.4	-0.1	0.1	-0.5	-0.5	0.0	-1.4	0.2	-0.4	0.1	-0.3	-0.1
Pulse wave reflection index	0.2	0.3	1.1	0.3	0.4	0.8	0.2	0.2	0.3	0.3	-0.8	0.4	0.1	0.3	1.1	0.5
Gout (self-reported)	0.2	0.3	1.1	-0.3	-0.1	-1.1	0.1	-0.5	-0.3	-0.5	-0.2	-0.8	0.1	-0.6	-1.0	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.7	-0.7	0.6	-0.7	0.1	0.0	-0.6	0.7	-0.5	0.3	-0.4	0.2	0.1
Leg fat percentage (right)	0.2	0.6	1.2	0.1	0.5	-0.8	0.5	1.1	0.9	0.6	1.0	-0.9	0.8	0.9	0.6	1.0
Emphysema/chronic bronchitis	0.2	0.2	1.1	0.1	-0.4	-0.1	-0.4	-0.1	0.0	-0.6	1.1	-1.0	0.1	-0.3	0.3	-0.3
Migraine (self-reported)	0.2	0.2	1.1	0.1	0.1	-1.0	0.0	-0.1	0.1	-0.2	0.7	0.0	0.1	0.3	0.8	0.3
Leg fat mass (right)	0.2	0.8	2.6	-1.4	-0.8	-1.1	-1.0	-0.4	-0.6	-0.8	-0.3	-1.6	-0.5	-0.6	-0.9	-0.6
Number of full sisters	0.2	0.3	1.5	-0.2	-0.5	1.2	0.3	-0.2	-0.4	-0.2	0.7	0.2	-0.3	-0.5	0.4	-0.5
Hypertension (Self-reported)	0.2	0.4	1.2	0.6	0.4	0.6	0.7	1.1	1.0	0.8	0.7	-0.1	0.7	0.7	-0.1	0.1
Average weekly red wine intake	0.2	0.4	1.1	0.1	-0.3	0.7	0.2	0.4	0.4	0.5	1.0	0.9	0.8	0.5	-0.1	0.9
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.2	0.1	-0.8	0.1	0.5	0.4	-0.1	1.0	-0.9	0.1	0.5	-0.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.2	0.8	0.5	-0.4	0.4	0.5	0.2	0.4	-0.4	-0.6	-0.0	-0.3	0.1
Miserableness	0.2	0.4	1.0	-0.9	-0.6	-0.2	-0.8	-0.7	-1.0	-0.9	0.5	0.0	-0.2	-0.8	0.2	-0.3
Guilty feelings	0.2	0.3	0.9	-0.2	0.9	0.8	0.4	0.0	-0.1	0.2	-0.8	-0.0	0.1	0.6	-0.5	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	1.3	0.1	0.1	-0.1	0.0	0.8	0.7	0.2	0.6	-0.3	0.1	-0.0	-1.1	0.5
Medication: Bendroflumethiazide	0.2	0.4	1.3	0.0	-0.2	1.0	1.1	0.5	0.6	0.6	-0.2	0.8	0.7	0.5	-0.1	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.2	-0.8	0.0	-0.6	-0.3	-0.2	-0.6	0.2	-0.7	-0.2	-0.2	0.7	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	1.1	0.8	0.2	0.7	0.6	0.4	0.5	0.4	0.4	1.0	0.4	0.5	0.1	0.0
Myopia	0.2	0.3	0.9	0.4	0.4	0.9	0.7	0.8	0.7	0.4	0.1	0.6	0.6	0.4	0.5	0.4
Supplements: Calcium	0.2	0.3	1.1	0.0	1.0	-0.9	0.4	0.1	0.1	0.3	-0.0	-0.6	-0.0	0.2	0.7	0.5
Heart disease (siblings)	0.2	0.2	0.9	0.7	0.0	0.2	0.4	0.4	0.5	0.0	0.5	0.2	0.6	-0.0	1.0	0.3
Depression (Nagel 2018)	0.1	0.2	0.9	0.3	0.3	-0.1	0.7	-0.3	-0.1	0.0	0.7	1.0	0.1	0.1	-0.0	0.5
Ovarian Cancer	0.1	0.2	0.8	-0.8	-0.5	0.9	0.1	-0.1	-0.3	-0.3	-0.5	0.6	-0.3	-0.1	0.0	-0.1
Prostate Cancer	0.1	0.2	0.9	-0.4	0.1	0.7	-0.1	0.0	-0.1	-0.0	0.6	-0.4	-0.0	0.2	0.9	-0.3
Rheumatoid Arthritis	0.1	0.2	0.8	-0.3	-0.2	0.9	0.1	0.2	0.2	-0.1	-0.1	0.2	-0.6	-0.1	-0.7	0.2
Triglycerides	0.1	0.2	1.5	-0.3	-0.0	-1.2	0.2	-0.7	-0.6	-0.1	-0.1	0.5	0.2	-0.2	-0.4	-0.3
Blood White Count	0.1	0.8	2.1	-0.1	-0.4	-1.0	0.1	-1.2	-1.2	-0.8	-1.4	-0.4	-0.7	-0.8	-1.4	-0.4
Waist Hip Ratio (WHR)	0.1	0.2	0.8	-0.1	-0.7	0.1	0.0	-0.6	-0.9	-0.5	-0.2	-0.6	0.5	-0.1	0.4	-0.8
Tanning	0.1	0.8	1.7	-1.3	0.2	1.2	-1.3	-0.6	-0.4	-1.0	-1.0	-0.8	-1.0	-1.0	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.2	0.6	-0.5	0.8	-0.1	-0.2	0.3	0.1	0.7	0.1	0.4	0.3	0.3
Vitamin and mineral supplements	0.1	0.1	0.4	0.0	0.5	-0.6	0.0	0.2	0.1	0.3	0.3	0.5	0.3	0.2	0.4	0.3
Trunk fat percentage	0.1	0.3	1.3	0.1	0.1	-0.7	0.3	0.8	0.7	0.1	1.1	-0.4	0.5	0.2	-0.0	0.6
High blood pressure	0.1	0.3	0.9	0.4	0.2	0.6	0.3	0.9	0.9	0.5	0.6	-0.8	0.5	0.5	-0.2	-0.1
Stomach or abdominal pain in last month	0.1	0.2	0.6	-0.7	-0.0	0.7	0.2	-0.0	-0.0	-0.7	-0.3	0.6	-0.5	-0.1	0.0	0.1
Supplements: Glucosamine	0.1	0.1	0.6	0.8	0.2	0.4	0.4	0.1	0.3	-0.0	-0.3	-0.1	0.3	-0.5	-0.2	-0.2
Trunk fat mass	0.1	0.6	1.4	-1.1	-0.9	-0.9	-0.9	-0.2	-0.3	-0.9	0.3	-1.2	-0.4	-0.7	-0.7	-0.5
Forced vital capacity (FVC)	0.1	0.2	0.7	0.5	0.1	0.9	-0.3	0.5	0.4	0.0	0.8	0.8	0.4	0.2	0.2	0.0
Arm fat percentage (right)	0.1	0.4	1.6	0.0	0.4	-0.8	0.2	0.9	0.8	0.4	1.3	-0.5	0.6	0.6	0.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	0.6	0.6	0.4	0.3	0.7	0.7	0.3	0.8	0.8	0.4	0.6	0.5	0.4
Prospective memory result	0.1	0.2	0.6	-0.1	0.4	-0.1	0.7	0.1	-0.0	0.3	0.2	0.8	0.4	0.6	-0.3	0.5
Tense / ‘highly strung’	0.1	0.1	0.4	-0.3	-0.2	-0.5	0.0	-0.4	-0.6	-0.2	0.0	-0.5	-0.2	-0.2	-0.6	0.1
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.6	-0.0	-0.7	-0.3	-0.4	-0.3	-0.7	0.5	0.5	-0.7	-0.2	-0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	0.3	0.5	0.0	0.9	-0.1	0.1	0.8	-0.2	0.3	0.4	0.4	0.4	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	1.8	0.1	0.0	1.3	-0.3	0.4	0.2	0.1	0.5	0.7	0.4	0.2	0.7	-0.0
Body fat percentage	0.1	0.4	1.5	0.1	0.2	-0.8	0.4	0.9	0.8	0.3	1.2	-0.5	0.7	0.5	0.2	0.8
Comparative body size at age 10	0.1	0.4	1.3	0.1	0.3	-1.1	-0.0	-0.4	-0.3	-0.7	0.0	-0.3	-0.8	-0.2	-1.1	-0.7
Qualifications: College or University degree	0.1	0.4	2.9	0.7	0.0	1.7	0.2	0.4	0.6	0.4	-1.0	0.2	0.4	0.1	0.3	-0.2
Medication: Allopurinol	0.1	0.1	0.9	0.2	-0.0	-0.6	0.1	-0.2	-0.1	-0.0	-0.1	-0.2	0.2	-0.5	-1.0	-0.4
Whole body fat mass	0.1	0.6	1.6	-1.2	-0.9	-0.8	-0.9	-0.2	-0.4	-0.9	0.1	-1.3	-0.3	-0.7	-0.7	-0.6
Arm fat percentage (left)	0.1	0.5	1.2	0.3	0.6	-0.8	0.3	1.1	1.0	0.5	1.1	-0.5	0.7	0.7	0.1	0.9
Loneliness, isolation	0.1	0.1	0.4	0.5	0.2	0.3	0.1	-0.2	-0.4	-0.4	-0.1	0.3	-0.3	-0.7	-0.0	-0.5
Diabetes diagnosed by doctor	0.1	0.1	0.5	-0.6	-0.1	0.1	-0.1	-0.0	-0.2	-0.1	0.7	-0.3	0.1	-0.2	-0.6	-0.2
Breast cancer (self-reported)	0.1	0.1	0.4	0.4	0.2	-0.2	0.5	0.3	0.3	0.4	-0.1	0.5	0.7	0.3	-0.5	0.2
Illnesses of father: None of the above (group 1)	0.1	0.2	0.8	-0.5	-0.5	0.4	-0.2	-0.4	-0.3	-0.5	-0.4	0.9	-0.3	-0.2	-0.2	-0.4
Arm fat mass (left)	0.1	0.6	1.9	-1.0	-0.7	-0.8	-1.0	-0.2	-0.3	-0.8	-0.0	-1.4	-0.5	-0.6	-0.9	-0.5
High cholesterol (Self-reported)	0.1	0.1	0.9	-0.3	-0.9	0.2	0.1	-0.0	-0.1	-0.2	-0.0	0.1	0.0	-0.1	0.2	-0.5
Medication: Paracetamol	0.1	0.1	0.3	-0.2	0.3	0.3	-0.1	0.0	0.3	-0.3	-0.6	0.4	0.2	-0.4	-0.5	-0.0
Leg fat percentage (left)	0.1	0.4	1.2	-0.1	-0.1	-0.9	0.3	0.8	0.6	0.1	1.1	-0.9	0.6	0.5	0.6	0.6
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.1	-0.5	0.4	-0.5	-0.1	-0.4	0.1	-0.3	-0.7	-0.0	-0.1	-0.2	0.0
Age started oral contraceptive pill	0.1	0.2	1.1	-0.1	-0.4	1.1	0.0	0.4	0.5	-0.0	0.2	0.3	0.3	-0.1	0.4	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.3	-0.1	-0.4	-0.3	-0.7	-0.7	-0.3	-0.2	0.6	-0.3	-0.3	0.5	0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.3	0.3	-0.5	-0.1	-0.2	-0.2	-0.4	0.1	-0.5	-0.1	-0.2	-0.2	0.3
Blood Red Count	0.0	0.5	1.9	-0.2	-0.2	-0.7	-0.7	-0.3	0.0	-0.7	-0.7	-1.4	-0.8	-0.8	-0.8	-0.5
Lung FEV1/FVC ratio	0.0	0.2	0.9	-0.3	0.1	-0.4	0.1	-0.0	0.1	-0.4	0.5	-0.9	-0.7	0.0	0.0	0.1
Hair Pigment	0.0	0.2	0.5	0.7	0.6	-0.3	0.4	-0.2	-0.3	0.1	-0.2	-0.7	-0.1	0.2	-0.7	0.1
Hand grip strength (left)	0.0	0.1	0.5	-0.3	0.1	0.7	-0.2	0.3	0.2	0.2	0.3	-0.3	0.0	0.2	0.3	0.2
Hand grip strength (right)	0.0	0.1	1.0	-0.2	-0.3	-0.4	-0.3	-0.0	0.0	0.1	-0.3	-1.0	-0.2	0.2	-0.1	0.0

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Trait associations