TWAS hub - LBX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.126	0.0457	2.6e-05	0.047	NA	0.021	NA	0.047	1.3e-04	NA	8.2e-03	NA	1.4e-04
2	GTEx	Colon Sigmoid	0.277	0.0890	5.2e-05	0.108	NA	0.155	NA	0.146	1.2e-04	NA	4.0e-06	NA	7.6e-06
3	GTEx	Colon Transverse	0.110	0.0450	6.1e-04	0.129	NA	0.093	NA	0.090	9.9e-07	NA	3.3e-05	NA	4.5e-05
4	GTEx	Esophagus Mucosa	0.278	0.0720	3.9e-11	0.197	NA	0.134	NA	0.208	3.0e-13	NA	3.0e-09	NA	6.3e-14
5	GTEx	Esophagus Muscularis	0.126	0.0470	6.7e-05	0.071	NA	0.073	NA	0.071	4.3e-05	NA	3.3e-05	NA	4.3e-05
6	GTEx	Heart Atrial Appendage	0.128	0.0590	5.4e-03	0.028	NA	0.016	NA	0.017	1.9e-02	NA	6.1e-02	NA	5.5e-02
7	GTEx	Lung	0.222	0.0523	1.9e-12	0.237	NA	0.224	NA	0.222	4.1e-18	NA	4.0e-17	NA	6.5e-17
8	GTEx	Thyroid	0.392	0.0580	0.0e+00	0.408	NA	0.387	NA	0.398	2.4e-33	NA	2.7e-31	NA	2.3e-32
9	GTEx	Uterus	0.258	0.1310	8.7e-03	0.086	NA	0.007	NA	0.064	8.5e-03	NA	2.3e-01	NA	2.1e-02
10	GTEx	Vagina	0.198	0.0890	4.9e-03	0.278	NA	0.068	NA	0.158	4.3e-07	NA	1.2e-02	NA	1.8e-04
11	GTEx	Whole Blood	0.118	0.0360	1.1e-07	0.119	NA	0.114	NA	0.114	4.3e-11	NA	1.2e-10	NA	1.1e-10
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.120	0.0820	5.1e-04	0.040	0.03	0.022	NA	0.029	2.5e-03	0.0074	2.0e-02	NA	8.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Falls in the last year	5.9	8.0	9.9	2.5	2.1	3.0	3.1	3.0	2.8	3.0	2.9	2.9	2.7	3.1	2.5
Blood Platelet Count	5.7	65.6	85.9	7.4	5.2	8.5	8.9	8.6	9.3	7.9	8.9	7.4	8.8	8.6	6.8
Mouth/teeth dental problems: Mouth ulcers	5.6	8.9	11.7	2.9	2.2	3.0	3.2	3.4	2.7	3.3	3.1	2.9	3.3	3.1	2.4
Alzheimer’s Disease (in father)	5.2	5.6	7.1	-1.8	-1.6	-2.5	-2.4	-2.5	-2.4	-2.3	-2.4	-2.3	-2.6	-2.7	-2.5
Alzheimer’s Disease (including proxy)	5.0	7.3	9.0	-2.4	-1.7	-3.0	-2.9	-3.0	-2.9	-2.7	-3.0	-2.5	-2.9	-2.7	-2.4
Hayfever, allergic rhinitis or eczema	5.0	10.8	15.3	3.9	1.8	3.6	3.7	3.7	3.3	3.4	3.8	2.9	3.5	3.5	1.4
Average weekly champagne plus white wine intake	4.7	6.4	10.0	-1.8	-1.8	-2.6	-3.0	-2.5	-2.8	-2.1	-3.2	-1.9	-2.6	-2.3	-3.1
Age at First Birth	4.5	6.6	12.0	-2.5	-2.8	-2.6	-2.6	-2.7	-2.0	-2.3	-2.6	-2.1	-2.5	-2.2	-3.5
Allergy	4.5	10.3	13.5	-3.5	-2.0	-3.4	-3.6	-3.5	-3.4	-3.5	-3.7	-3.0	-3.3	-3.4	-1.3
Time employed in main current job	3.9	4.5	7.0	-2.4	-1.7	-2.3	-2.3	-2.1	-2.0	-1.5	-2.4	-1.4	-2.2	-2.2	-2.6
Pain experienced in last month	3.9	6.6	10.2	-2.0	-2.1	-2.7	-2.8	-2.6	-2.8	-2.4	-3.0	-2.3	-2.6	-2.2	-3.2
High blood pressure (siblings)	3.8	5.5	7.2	-2.3	-2.5	-2.4	-2.6	-2.5	-2.3	-2.7	-2.4	-2.6	-2.0	-2.2	-1.4
Medication: Co-codamol	3.5	4.0	4.8	2.2	2.2	2.2	2.1	2.2	1.8	2.0	2.1	2.2	2.0	1.6	1.6
Hair/balding pattern: Pattern 2	3.5	4.4	6.7	-1.7	-0.9	-2.3	-2.2	-2.0	-2.4	-2.1	-2.0	-2.3	-2.5	-2.6	-1.5
Medication: Omeprazole	3.5	4.2	5.9	-1.8	-1.7	-2.1	-2.0	-2.2	-1.8	-2.4	-1.8	-2.2	-2.1	-2.4	-1.9
Illnesses of father: Heart disease	3.4	4.7	6.5	-1.5	-2.5	-2.3	-2.0	-2.0	-2.5	-1.7	-2.3	-1.8	-2.4	-2.1	-2.3
Diabetes (father)	3.3	4.1	5.6	-1.6	-1.6	-2.3	-2.3	-1.8	-1.8	-1.8	-2.2	-1.9	-2.2	-2.2	-2.4
Medication: Atenolol	3.2	4.0	6.7	-1.9	-0.6	-2.1	-2.1	-2.1	-1.8	-2.2	-1.9	-1.9	-2.5	-2.6	-1.3
Medication: Omeprazole (e.g. Zanprol)	3.2	3.8	5.7	-1.5	-1.7	-2.1	-1.9	-2.1	-1.8	-2.2	-1.8	-2.0	-2.1	-2.4	-1.8
Ever had hysterectomy (womb removed)	3.1	3.4	5.1	-1.7	-1.0	-2.0	-1.8	-1.7	-1.7	-1.9	-1.8	-1.9	-1.9	-2.3	-2.3
Medication: Levothyroxine sodium	3.1	5.3	7.4	2.4	2.3	2.2	2.5	2.4	2.4	2.7	2.3	2.6	1.6	1.7	2.4
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	12.0	2.8	3.5	2.6	2.4	2.7	1.5	2.9	2.3	2.5	2.3	2.4	1.8
Irritability	3.1	5.3	6.7	-2.2	-2.5	-2.5	-2.3	-2.4	-1.4	-2.5	-2.2	-2.6	-2.1	-2.3	-2.4
Bipolar Disorder (2011)	3.0	2.9	3.9	1.5	1.2	1.8	1.6	1.8	2.0	1.9	1.6	2.0	1.7	1.8	1.6
Leg pain on walking	3.0	3.8	5.8	2.2	1.1	2.0	1.9	2.3	1.0	2.4	1.6	2.4	1.6	1.8	2.4
Financial difficulties in last 2 years	2.9	3.9	5.1	1.8	1.0	2.2	2.1	2.1	2.3	1.8	2.2	1.7	2.3	2.1	1.9
Trunk fat-free mass	2.9	16.8	20.2	4.0	2.4	4.5	4.5	4.2	3.8	4.4	4.4	4.3	4.4	4.4	3.4
Whole body fat-free mass	2.9	16.5	20.4	3.9	2.5	4.5	4.4	4.2	3.7	4.3	4.3	4.2	4.5	4.4	3.5
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.1	-1.3	-0.6	-1.7	-1.8	-1.6	-2.2	-1.4	-1.9	-1.0	-2.2	-2.0	-2.2
Pulse rate	2.8	4.8	6.5	1.9	1.5	2.2	2.4	2.2	2.4	2.1	2.2	2.4	2.6	2.5	1.6
Trunk predicted mass	2.8	15.9	19.3	3.9	2.4	4.4	4.4	4.0	3.7	4.3	4.3	4.2	4.3	4.2	3.2
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	5.5	2.4	1.5	1.9	1.9	1.6	2.3	2.0	1.9	2.2	1.6	1.6	1.8
Health satisfaction	2.8	3.7	7.2	1.5	1.4	2.2	1.9	1.8	1.0	1.7	2.0	1.7	2.3	2.3	2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.4	7.9	2.0	0.8	1.8	2.2	1.6	2.8	2.0	2.1	1.9	1.5	1.7	0.3
Leg fat-free mass (right)	2.8	15.2	20.3	3.6	2.6	4.3	4.1	4.1	3.4	4.1	4.0	4.0	4.5	4.2	3.4
Whole body water mass	2.8	15.7	19.6	3.8	2.4	4.4	4.3	4.1	3.6	4.2	4.2	4.1	4.4	4.3	3.4
Leg predicted mass (right)	2.8	15.1	20.2	3.6	2.6	4.3	4.0	4.1	3.4	4.1	4.0	4.0	4.5	4.2	3.4
Alzheimer’s Disease (in mother)	2.7	3.2	4.2	-2.0	-0.9	-2.1	-2.0	-2.0	-1.7	-1.9	-2.0	-1.5	-1.9	-1.6	-1.2
Wears glasses or contact lenses	2.7	3.1	5.7	1.1	0.1	2.0	2.0	1.7	1.8	1.7	2.0	1.6	2.2	2.4	1.5
Supplements: Zinc	2.6	2.9	4.1	-1.8	-1.6	-1.6	-1.8	-1.9	-2.0	-1.4	-1.7	-1.7	-1.7	-1.5	-1.4
Leg fat-free mass (left)	2.6	13.8	18.5	3.4	2.5	4.1	3.8	3.9	3.1	3.8	3.8	3.8	4.3	4.1	3.5
Leg predicted mass (left)	2.6	14.0	19.0	3.4	2.5	4.2	3.8	3.9	3.1	3.9	3.8	3.8	4.4	4.1	3.6
Medication: Lansoprazole	2.6	3.0	4.2	-1.7	-1.2	-1.7	-1.9	-1.8	-2.1	-1.8	-1.9	-2.0	-1.8	-1.9	-0.9
Medication: Seretide 50 evohaler	2.6	3.0	5.0	1.4	0.9	1.8	2.0	1.6	2.2	1.6	2.2	1.6	1.7	1.4	1.8
Number of operations (self-reported)	2.6	3.9	5.2	1.6	1.5	2.0	2.2	2.3	1.8	1.7	2.3	1.9	2.3	1.8	2.1
Unable to work because of sickness or disability	2.6	3.3	7.7	1.8	1.4	1.9	1.7	1.8	1.4	1.7	1.9	1.8	1.6	1.6	2.8
HbA1C	2.5	2.7	4.2	-1.8	-1.6	-1.9	-1.6	-1.5	-1.1	-1.5	-1.7	-1.5	-1.5	-2.1	-1.9
Pulse wave Arterial Stiffness index	2.5	3.0	5.0	2.1	1.4	1.7	1.6	1.9	1.4	1.5	1.7	1.4	2.2	1.7	1.7
Basal metabolic rate	2.5	13.8	17.6	3.5	2.2	4.1	4.0	3.9	3.4	3.9	4.0	3.8	4.2	4.0	3.3
Arm fat-free mass (left)	2.5	12.8	15.7	3.4	1.8	3.9	4.0	3.7	3.6	3.7	3.9	3.7	3.9	3.7	2.9
Average weekly fortified wine intake	2.4	2.8	4.0	-1.7	-1.1	-1.8	-1.8	-1.6	-1.9	-1.6	-2.0	-1.6	-1.9	-1.9	-0.5
Mouth/teeth dental problems	2.4	3.7	5.4	-1.6	-2.3	-2.1	-2.1	-1.7	-2.1	-1.5	-2.2	-1.6	-1.9	-1.8	-2.1
Pulse wave peak to peak time	2.4	2.8	4.9	-2.0	-1.5	-1.7	-1.5	-1.9	-1.5	-1.4	-1.7	-1.3	-2.2	-1.6	-1.6
Arm predicted mass (left)	2.4	12.0	15.1	3.3	1.6	3.9	3.9	3.5	3.5	3.6	3.9	3.6	3.9	3.6	2.7
Allergy or Eczema	2.3	6.0	8.4	2.8	0.9	2.7	2.9	2.8	2.6	2.6	2.9	2.1	2.6	2.6	0.6
Had other major operations	2.3	2.8	4.1	1.3	-0.2	2.0	2.0	1.6	1.6	1.4	2.0	1.7	1.8	2.0	1.9
Shortness of breath walking on level ground	2.3	2.8	3.9	1.2	2.0	1.8	1.6	1.5	1.6	1.3	1.7	1.6	1.8	1.9	1.8
Comparative height size at age 10	2.3	12.9	18.7	3.8	2.0	3.9	3.8	3.8	3.5	3.6	3.9	3.0	4.3	4.0	2.8
Breastfed as a baby	2.2	2.8	4.5	-1.6	-1.1	-1.7	-2.0	-1.9	-2.0	-1.4	-2.1	-1.4	-1.8	-1.1	-1.4
Commuting to job workplace: Walk	2.2	2.4	3.7	1.2	0.8	1.9	1.7	1.5	1.2	1.4	1.9	1.0	1.9	1.8	1.9
Osteoporosis (self-reported)	2.2	2.8	5.5	-1.7	-2.3	-1.8	-1.6	-1.9	-1.3	-1.5	-1.7	-1.3	-1.7	-1.5	-1.4
Arm fat-free mass (right)	2.1	10.6	13.8	3.0	1.2	3.6	3.6	3.3	3.2	3.5	3.6	3.2	3.7	3.5	2.6
Age at first live birth	2.1	3.7	5.6	-1.6	-1.3	-2.2	-2.3	-1.7	-2.0	-1.6	-2.4	-1.7	-2.1	-1.8	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	7.0	-2.2	-0.9	-2.5	-2.6	-2.0	-2.0	-2.3	-2.7	-2.4	-1.8	-1.9	-1.4
Arm predicted mass (right)	2.0	10.2	13.7	3.0	1.6	3.6	3.5	3.2	3.1	3.4	3.6	3.2	3.7	3.5	2.6
Suffer from ‘nerves’	2.0	3.2	6.8	-1.2	-0.5	-2.0	-2.0	-1.7	-1.8	-1.9	-1.8	-1.7	-2.3	-2.6	-1.0
Age at last live birth	2.0	2.8	4.4	-1.6	-1.6	-1.8	-2.0	-1.6	-2.1	-1.4	-2.1	-1.5	-1.4	-1.0	-1.7
Alcohol usually taken with meals	1.9	3.0	4.7	-2.2	-1.5	-1.9	-1.8	-1.5	-1.7	-1.6	-1.8	-1.8	-1.4	-1.7	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.5	-1.0	-1.5	-1.6	-1.6	-1.8	-1.3	-1.0	-1.8	-0.7	-1.9	-1.5	-1.5
Ever taken oral contraceptive pill	1.9	2.1	2.5	1.0	1.6	1.6	1.4	1.4	1.6	1.3	1.5	1.4	1.6	1.4	1.5
Back pain experienced in last month	1.8	2.7	4.4	1.3	2.1	1.5	1.7	1.8	1.8	1.3	1.9	1.0	1.9	1.0	2.0
Financial situation satisfaction	1.8	2.3	3.7	1.1	0.6	1.8	1.7	1.3	1.9	1.0	1.9	0.9	1.7	1.5	1.9
Blood Eosinophil Count	1.7	12.8	25.9	5.1	1.6	3.6	3.5	3.5	3.4	3.5	3.4	3.5	3.6	3.9	3.4
Chronic bronchitis/emphysema (father)	1.7	2.0	3.3	1.3	1.7	1.7	1.6	1.4	1.1	1.3	1.8	1.2	1.0	0.9	1.7
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	3.5	-1.4	-0.6	-1.6	-1.6	-1.6	-1.8	-1.3	-1.9	-0.9	-1.3	-1.1	-1.7
Osteoarthritis (self-reported)	1.7	2.2	3.1	1.6	0.9	1.6	1.5	1.6	1.8	1.0	1.7	1.0	1.8	1.5	1.7
Schizophrenia (2014)	1.6	3.6	6.2	1.9	0.1	2.1	1.9	1.9	2.2	1.3	2.2	1.0	2.5	2.3	1.9
Hair/balding pattern: Pattern 4	1.6	3.9	5.8	2.0	0.4	2.0	2.3	1.9	2.0	2.4	2.0	2.1	2.2	2.4	1.3
Lupus	1.5	2.3	6.6	1.6	-0.2	1.4	1.6	1.4	2.6	1.2	1.7	1.4	1.6	1.1	1.5
Height	1.5	28.5	37.5	6.1	3.7	5.9	5.6	5.2	5.2	5.7	5.7	5.3	5.7	5.3	4.0
Respiratory disease	1.5	3.3	5.6	1.5	0.6	2.1	2.0	1.7	2.2	1.7	2.4	1.5	1.8	1.8	1.9
Mouth/teeth dental problems: Loose teeth	1.5	1.7	2.8	1.3	0.8	1.6	1.3	0.9	1.4	0.9	1.5	1.1	1.4	1.5	1.7
Medication: Blood pressure	1.5	2.9	4.2	-1.5	-1.8	-1.7	-1.5	-1.9	-1.8	-1.8	-1.5	-1.7	-1.9	-2.0	-1.2
Medication: Lisinopril	1.5	1.9	3.7	-1.5	-1.9	-1.4	-1.1	-1.5	-0.8	-1.6	-1.0	-1.1	-1.2	-1.6	-1.5
Cholesterol lowering medication	1.5	2.3	3.6	1.3	0.8	1.6	1.6	1.5	1.9	1.2	1.7	1.2	1.7	1.5	1.6
Lung FVC	1.4	6.9	8.9	-2.9	-2.7	-2.8	-2.7	-2.7	-2.3	-3.0	-2.6	-2.9	-2.4	-2.7	-1.9
Systolic blood pressure, automated reading	1.4	4.0	6.0	-1.6	-1.8	-2.0	-1.9	-2.0	-2.3	-1.7	-2.0	-1.8	-2.5	-2.2	-1.9
Standing height	1.4	14.3	19.3	4.3	2.5	4.0	4.0	4.0	3.4	4.2	4.0	3.5	4.4	3.9	2.4
Family relationship satisfaction	1.4	1.8	3.1	-1.3	-1.8	-1.4	-1.2	-1.4	-1.1	-1.2	-1.3	-1.5	-1.2	-1.3	-1.2
Severe depression (siblings)	1.3	1.4	4.4	1.1	2.1	1.0	1.1	1.3	1.1	1.3	1.2	1.3	0.8	0.7	0.7
Wheeze or whistling in the chest in last year	1.3	2.3	4.2	1.3	1.4	1.8	1.6	1.4	1.3	1.0	1.7	1.3	1.5	1.4	2.1
Neck or shoulder pain in last month	1.3	1.8	3.9	0.8	0.7	1.4	1.4	1.3	1.5	1.1	1.5	1.0	2.0	1.6	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.2	-0.7	-0.8	-1.4	-1.1	-1.3	-0.9	-1.1	-1.2	-1.1	-1.5	-1.6	-1.8
Number of live births	1.2	1.7	4.2	0.6	-0.5	1.5	1.3	1.1	1.6	0.8	1.4	0.8	1.9	2.1	1.2
Birth weight of first child	1.2	2.2	4.1	1.5	0.8	1.3	1.6	1.7	2.0	1.4	1.5	1.4	1.8	1.2	1.1
Medication: Paracetamol	1.2	1.9	5.3	0.8	1.0	1.6	1.4	1.5	1.4	1.2	1.6	1.1	1.2	1.0	2.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.1	1.5	1.7	1.4	1.5	1.5	1.6	1.7	1.5	1.8	0.9	0.9	1.7
Medication: Aspirin	1.2	1.5	2.5	-0.7	-1.6	-1.5	-1.2	-1.2	-1.4	-1.0	-1.4	-0.9	-1.3	-1.6	-0.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.5	-1.6	-0.1	-1.2	-1.1	-1.2	-1.5	-1.2	-1.0	-1.0	-1.3	-1.3	-0.8
Average weekly spirits intake	1.1	1.3	1.7	1.1	0.9	1.2	1.2	1.2	1.1	1.1	1.1	1.3	1.2	1.2	1.3
Weight	1.1	5.4	8.3	2.0	0.7	2.6	2.5	2.4	2.2	2.2	2.5	2.3	2.9	2.5	2.3
Length of working week for main job	1.1	1.2	1.8	-1.2	-0.9	-1.1	-1.1	-1.4	-1.1	-1.0	-1.0	-1.2	-1.2	-1.1	-0.9
Had major operations	1.1	1.2	3.2	1.4	1.8	0.8	1.1	1.5	0.6	1.2	0.9	1.1	0.9	0.1	1.1
Qualifications: nursing, teaching	1.1	1.7	2.3	-1.3	-0.8	-1.5	-1.3	-1.2	-1.1	-1.3	-1.5	-1.5	-1.3	-1.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.6	0.4	0.5	1.1	1.4	0.9	2.1	0.8	1.6	0.8	1.3	1.0	0.5
Systolic Blood Pressure	1.0	5.2	8.7	-1.4	-1.5	-2.4	-2.3	-2.2	-3.0	-1.8	-2.5	-2.1	-2.6	-2.4	-2.6
Glaucoma (self-reported)	1.0	1.2	2.5	-1.3	-1.4	-1.1	-0.9	-1.3	-0.8	-1.0	-0.9	-0.7	-0.9	-1.6	-0.9
Number of full brothers	1.0	1.2	3.5	1.5	1.9	0.9	0.8	1.2	0.8	0.7	1.1	0.4	0.5	0.0	1.9
Number of children fathered	1.0	1.1	1.9	1.0	0.6	1.1	1.1	1.1	1.4	0.7	1.2	0.6	1.3	1.3	0.9
Mean time to correctly identify matches	1.0	1.9	2.9	1.4	-0.6	1.4	1.5	1.1	1.6	1.5	1.4	1.7	1.3	1.2	1.5
Pulse rate, automated reading	1.0	3.2	4.7	1.4	1.8	2.2	1.8	1.8	1.6	1.4	2.1	1.7	2.1	1.9	1.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.4	1.4	0.1	0.9	1.3	1.3	1.8	1.3	1.2	0.8	1.0	0.8	0.5
Crohns Disease (2012)	0.9	1.4	2.5	0.7	-0.3	1.3	1.4	1.3	1.6	0.8	1.5	0.7	1.5	1.2	1.3
Neuroticism	0.9	2.1	2.9	-0.7	-0.9	-1.5	-1.7	-1.4	-1.6	-1.2	-1.6	-1.4	-1.7	-1.6	-1.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.5	0.6	0.8	1.3	1.1	1.1	1.4	0.9	1.4	0.7	1.1	1.0	1.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.5	-1.2	-0.0	-1.1	-1.1	-1.0	-1.0	-1.0	-1.1	-1.2	-1.2	-1.0	-0.5
Townsend deprivation index at recruitment	0.9	1.2	3.0	1.1	1.7	1.3	1.1	1.0	1.0	1.0	1.0	1.5	0.7	0.7	0.8
Sitting height	0.9	6.5	10.6	2.3	2.1	2.8	2.6	2.8	2.1	2.8	2.8	2.4	3.3	2.6	1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.2	-1.1	-2.0	-0.9	-1.0	-0.9	-0.7	-1.0	-1.0	-1.2	-0.2	-0.1	-0.8
Depression (self-reported)	0.9	1.0	2.3	1.0	0.7	1.1	0.6	1.1	0.8	0.7	0.8	0.6	1.1	1.5	1.4
Supplements: Vitamin C	0.9	1.1	2.4	-1.0	-0.3	-1.1	-1.1	-1.0	-1.6	-1.0	-1.1	-1.3	-0.9	-0.9	-0.3
Knee pain experienced in last month	0.9	1.3	2.3	1.0	-0.2	1.1	1.5	1.2	1.5	1.0	1.4	0.9	1.5	1.2	0.8
Illnesses of siblings: Diabetes	0.9	1.1	1.7	1.2	0.3	1.1	1.1	0.8	1.2	1.2	1.1	1.0	1.3	1.2	0.7
Ever had bowel cancer screening	0.9	1.0	1.8	0.5	0.2	1.0	1.2	1.0	1.2	0.7	1.3	0.7	1.3	1.1	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.9	0.8	1.1	1.1	1.3	1.1	0.8	1.0	1.4	0.9	1.2	0.9	0.8
LDL Cholesterol	0.8	1.2	2.2	0.8	0.4	1.1	1.1	1.3	1.0	1.4	1.1	1.5	1.1	1.1	0.7
Heel T-Score	0.8	6.6	13.2	-2.1	-1.7	-2.7	-2.9	-2.6	-2.7	-2.4	-2.9	-2.2	-2.4	-2.1	-3.6
Angina	0.8	1.0	1.6	-1.1	-0.2	-1.2	-1.1	-1.1	-1.0	-1.1	-1.0	-0.7	-1.1	-1.0	-1.1
Illnesses of siblings	0.8	1.1	4.3	1.0	2.1	0.9	0.8	1.1	0.6	1.3	0.7	1.3	0.4	0.6	0.6
Medication: Cholesterol lowering	0.8	1.2	2.1	-0.5	-1.4	-1.4	-1.0	-1.3	-0.7	-0.6	-1.3	-0.2	-1.2	-1.3	-1.4
Mood swings	0.8	1.5	5.4	-0.5	-2.3	-1.0	-0.7	-0.9	-0.4	-0.5	-0.7	-0.8	-1.5	-1.7	-1.8
Mineral and other dietary supplements	0.8	1.1	2.4	-1.3	-0.2	-1.0	-1.2	-1.2	-1.6	-1.3	-1.1	-0.9	-0.8	-1.0	-0.5
Hearing aid user	0.8	0.9	1.4	1.0	0.7	0.9	1.2	1.0	1.0	1.0	1.2	1.1	0.6	0.4	0.8
Illnesses of father: High blood pressure	0.8	0.9	1.8	-1.2	-0.5	-1.0	-0.8	-1.0	-0.3	-1.2	-0.8	-1.4	-1.0	-1.1	-0.9
Diastolic blood pressure, automated reading	0.8	2.6	4.3	-1.3	-1.6	-1.5	-1.5	-1.8	-2.1	-1.4	-1.5	-1.4	-1.7	-1.7	-1.6
Ever depressed for a whole week	0.8	0.9	2.6	-0.1	-1.4	0.8	0.8	0.6	1.2	0.3	0.9	-0.0	1.6	1.6	0.7
Impedance of whole body	0.8	3.8	6.2	-1.1	-1.4	-2.2	-2.1	-1.9	-1.8	-2.1	-2.0	-2.5	-1.9	-2.2	-1.9
Neuroticism (Nagel 2018)	0.7	1.8	2.7	-1.1	-1.4	-1.4	-1.4	-1.1	-1.3	-1.5	-1.2	-1.6	-1.1	-1.6	-1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.8	3.3	-1.2	-1.8	-1.3	-1.3	-1.4	-1.2	-1.1	-1.3	-1.5	-1.3	-1.2	-1.1
Impedance of leg (right)	0.7	3.5	4.9	-1.1	-1.2	-2.1	-2.0	-1.9	-1.5	-2.0	-1.9	-2.2	-2.2	-2.2	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.8	-0.7	0.3	-1.4	-1.5	-1.2	-1.5	-1.2	-1.7	-1.2	-1.0	-1.1	-1.5
Impedance of leg (left)	0.7	3.6	5.5	-1.0	-1.6	-2.2	-1.7	-1.9	-1.2	-1.9	-1.7	-2.2	-2.1	-2.4	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	4.2	2.1	0.6	1.0	1.1	0.7	0.9	1.3	1.0	1.7	0.2	0.2	-0.0
Hearing difficulty/problems with background noise	0.7	1.1	3.5	-0.4	0.6	-0.9	-1.3	-0.9	-1.9	-1.0	-1.3	-0.8	-1.3	-1.2	0.0
Mouth/teeth dental problems: Dentures	0.7	1.1	2.3	-1.4	-0.6	-0.9	-1.0	-1.3	-1.2	-1.5	-0.8	-1.3	-0.9	-0.9	-0.5
Impedance of arm (left)	0.7	3.1	5.6	-1.2	-1.1	-1.9	-2.1	-1.6	-2.2	-1.9	-1.9	-2.4	-1.4	-1.7	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.4	1.1	1.0	1.1	0.9	1.0	0.6	1.0	1.0	0.8	1.1	1.2	1.1
Angina (self-reported)	0.7	0.9	1.4	-1.1	-0.2	-1.2	-1.0	-1.1	-1.0	-1.1	-1.0	-0.7	-1.1	-0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.7	2.4	-1.2	-1.6	-1.5	-1.3	-1.3	-1.1	-1.1	-1.4	-1.5	-1.2	-1.2	-1.1
Waist circumference	0.6	2.2	3.6	1.3	0.1	1.6	1.6	1.5	1.4	1.2	1.6	1.4	1.7	1.5	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.6	-0.9	0.1	-1.4	-1.4	-1.1	-1.6	-1.2	-1.5	-1.4	-1.0	-1.2	-1.1
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.2	-0.9	-1.2	-1.3	-1.2	-1.1	-1.5	-0.9	-1.4	-1.0	-1.4	-1.3	-1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	-1.1	-0.6	-0.9	-0.9	-0.5	-1.0	-1.2	-0.7	-1.3	-0.5	-0.8	-0.3
Asthma (self-reported)	0.6	1.2	2.1	1.0	-0.0	1.2	1.3	0.9	1.4	1.0	1.5	0.9	1.1	1.0	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	0.8	0.1	1.0	1.2	1.0	1.4	0.9	1.3	0.8	1.1	0.9	0.6
Mother’s age at death	0.6	0.8	3.3	0.6	-0.1	0.9	0.7	0.7	0.7	0.5	0.8	0.6	1.1	0.9	1.8
Bipolar Disorder or Schizophrenia	0.5	1.2	2.8	1.0	-0.5	1.0	0.9	1.1	1.5	1.0	0.9	0.9	1.7	1.6	0.3
Schizophrenia (2018)	0.5	1.1	2.7	0.9	-0.5	1.0	0.9	0.8	1.6	0.8	1.0	0.6	1.7	1.5	0.5
Reaction Time	0.5	0.9	1.8	0.9	-0.2	1.0	1.1	0.7	1.1	1.1	1.0	1.3	0.8	0.8	1.4
Chronotype (morning person)	0.5	1.2	2.1	0.9	0.9	1.0	1.1	1.0	0.8	1.4	0.9	1.4	1.5	1.4	-0.0
Fed-up feelings	0.5	0.9	2.4	-0.5	-1.6	-0.9	-0.8	-1.1	-0.8	-0.8	-0.8	-1.1	-0.9	-1.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.7	-1.0	0.5	1.1	0.6	1.0	0.7	1.3	0.4	0.8	0.3	-0.6
Impedance of arm (right)	0.5	2.1	3.3	-0.9	-0.8	-1.6	-1.8	-1.4	-1.7	-1.5	-1.7	-1.8	-1.3	-1.5	-1.1
Hip circumference	0.5	2.0	3.1	1.3	0.0	1.7	1.4	1.6	1.3	1.3	1.5	1.4	1.8	1.5	1.6
Hair/balding pattern: Pattern 3	0.5	0.8	1.5	-1.1	-0.2	-0.9	-1.2	-0.9	-0.6	-1.0	-1.2	-0.6	-1.1	-1.0	-0.2
Asthma	0.5	1.0	1.7	0.8	-0.1	1.1	1.1	0.9	1.3	0.9	1.3	0.7	1.0	1.0	1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	0.3	1.3	1.1	0.8	1.2	0.6	0.7	1.0	0.4	0.9	1.0	0.9
Worry too long after embarrassment	0.5	0.8	1.6	-0.4	-0.3	-1.2	-1.2	-0.9	-1.0	-0.8	-1.3	-0.9	-1.0	-0.9	-0.6
Eye problems/disorders: None of the above	0.5	0.6	1.0	0.7	0.7	1.0	0.7	0.8	0.5	0.6	1.0	0.3	0.9	1.0	0.4
Medication: Blood pressure	0.5	1.0	1.9	-0.4	-0.8	-1.1	-0.9	-1.3	-1.0	-0.6	-1.1	-0.4	-1.1	-1.0	-1.4
Medication: Ibuprofen	0.5	0.6	2.5	-0.0	-0.7	0.8	0.5	0.9	0.5	0.4	0.6	0.3	0.8	0.9	1.6
Heart disease (mother)	0.5	0.6	5.1	-0.8	-2.2	-0.4	-0.2	-0.4	0.0	-0.6	-0.2	-0.8	-0.1	-0.2	-0.4
Medication: Aspirin	0.5	0.6	1.7	-0.3	-1.3	-1.0	-0.7	-0.7	-0.9	-0.5	-0.8	-0.4	-0.8	-1.2	-0.1
Smoking status: Previous	0.5	0.7	2.1	0.6	1.0	1.0	0.6	0.6	0.6	0.5	0.6	0.7	1.1	1.4	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.9	-0.5	-1.4	-0.7	-0.7	-0.8	-0.6	-0.7	-0.6	-0.6	-0.7	-0.8	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-0.5	-0.6	-0.7	-0.8	-0.8	-1.0	-0.5	-0.9	-0.2	-0.8	-0.8	-1.3
Body Mass Index (BMI) (2010)	0.4	0.6	3.4	0.3	0.3	0.7	0.5	0.6	0.7	0.2	0.8	-0.0	0.8	0.9	1.8
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.3	0.0	-0.8	-0.6	-0.8	-1.1	-0.8	-0.8	-0.4	-0.7	-0.6	-0.3
Ulcerative Colitis	0.4	0.7	1.1	0.7	-0.1	0.9	0.7	0.7	1.0	0.8	0.7	1.1	1.0	1.0	0.4
Smoking Status	0.4	0.9	4.1	0.9	2.0	0.9	0.6	0.8	0.8	0.3	0.8	0.7	0.7	0.6	1.4
Number of treatments/medications taken	0.4	0.7	3.7	-0.7	-1.9	-0.7	-0.5	-0.8	-0.2	-0.7	-0.3	-0.9	-0.7	-1.0	-0.1
Medication for hormone replacement therapy	0.4	0.4	1.1	-1.0	-0.8	-0.5	-0.7	-0.7	-0.6	-0.8	-0.7	-0.6	-0.5	-0.5	-0.2
Current tobacco smoking	0.4	0.6	2.1	0.6	0.9	0.9	0.8	0.6	0.8	0.3	1.0	0.5	0.7	0.6	1.4
Multivitamins +/- minerals	0.4	0.5	1.6	1.3	0.6	0.7	0.8	0.5	0.4	0.6	0.7	0.4	0.7	0.9	0.5
Past tobacco smoking	0.4	0.7	2.0	-0.6	-0.9	-1.1	-0.8	-0.6	-1.0	-0.3	-0.8	-0.7	-1.2	-1.4	-0.3
Had menopause	0.4	0.5	1.0	0.1	-1.0	0.7	0.9	0.5	0.9	0.4	0.9	0.3	0.8	0.6	0.6
Heart attack	0.4	0.5	1.5	0.9	0.1	0.7	0.7	0.4	0.4	0.8	0.5	1.2	0.3	0.4	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.0	0.5	-0.6	0.6	1.0	0.8	0.9	0.9	0.9	0.5	0.8	0.8	-0.2
Noisy workplace	0.4	0.5	1.2	1.1	1.1	0.6	0.6	0.8	0.6	0.5	0.6	0.8	0.5	0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.1	-0.7	-1.4	-0.4	-0.4	-0.5	0.2	-0.7	-0.1	-1.1	-0.7	-0.5	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.2	0.2	-0.7	0.8	0.5	0.9	0.3	0.5	0.6	0.3	0.8	1.0	1.5
Medication: Amlodipine	0.4	0.5	1.4	-0.4	-0.3	-0.6	-0.7	-1.2	-1.1	-0.3	-0.9	-0.2	-0.9	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.2	-0.2	-1.5	0.5	0.3	0.3	0.8	0.0	0.8	-0.4	1.0	0.6	1.0
Overall health rating	0.4	0.9	4.3	-0.1	1.0	1.2	0.8	0.9	0.6	0.5	1.1	0.5	0.8	0.6	2.1
Friendships satisfaction	0.4	0.5	1.4	1.0	0.5	0.8	0.6	0.6	0.5	0.7	0.8	0.1	0.3	0.3	1.2
Eye problems/disorders: Cataract	0.4	0.5	1.1	-0.1	-0.3	-0.9	-0.8	-0.8	-0.4	-0.6	-0.9	-0.2	-1.1	-1.0	-0.6
Medication for cholesterol	0.4	0.6	1.1	0.9	1.1	0.5	0.7	0.9	0.8	0.9	0.7	0.6	0.9	0.8	0.5
Smoking status: Current	0.4	0.6	1.8	0.5	0.8	0.8	0.7	0.6	0.8	0.3	1.0	0.5	0.6	0.4	1.3
Miserableness	0.4	0.6	1.1	0.8	-0.4	0.9	0.9	1.0	0.8	0.6	1.1	0.2	0.9	0.4	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	1.0	0.2	0.8	0.8	0.4	0.5	0.8	0.6	1.3	0.3	0.4	1.0
Depressed Affect (Nagel 2018)	0.3	0.7	3.4	-0.4	-1.8	-0.6	-0.6	-0.7	-0.9	-0.6	-0.5	-1.1	-0.6	-0.9	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.8	-0.1	0.7	0.8	0.4	0.9	0.4	0.8	0.3	0.5	0.6	0.5
Major Depression (MDD)	0.3	0.4	1.1	-1.1	-0.1	-0.4	-0.7	-0.5	-1.0	-0.9	-0.6	-0.7	-0.1	0.1	-0.2
Breast Cancer	0.3	0.6	1.8	-0.3	-0.5	-0.8	-0.7	-0.9	-1.1	-0.3	-1.0	-0.3	-0.8	-0.5	-1.4
Mean Putamen Volume	0.3	0.4	1.5	0.1	-0.5	0.6	0.6	0.4	0.9	0.3	0.8	0.4	0.6	0.4	1.2
Primary Biliary Cirrhosis	0.3	0.4	1.4	0.4	0.4	0.7	0.5	0.2	1.2	0.2	0.7	0.3	0.6	0.5	1.0
BMI	0.3	1.8	4.2	1.0	-0.3	1.5	1.4	1.4	0.9	1.0	1.2	1.4	2.1	1.7	1.5
Medication: Metformin	0.3	0.4	1.3	0.4	-0.2	0.9	0.8	0.4	0.4	0.3	0.9	0.2	0.5	0.7	1.1
Relative age voice broke	0.3	0.5	1.3	-0.2	-0.6	-0.7	-0.6	-1.0	-0.7	-0.4	-0.9	-0.2	-1.1	-0.4	-1.0
Taking other prescription medications	0.3	0.5	2.6	0.4	-1.6	0.5	0.8	0.3	0.9	0.3	0.9	0.0	0.7	0.3	0.2
Fluid intelligence score	0.3	0.7	3.4	-0.9	-1.8	-0.6	-0.7	-0.9	-0.9	-0.5	-0.7	-0.9	-0.3	-0.2	-0.7
Father’s age at death	0.3	0.4	0.9	-0.9	0.2	-0.3	-0.7	-0.8	-0.3	-0.7	-0.5	-0.6	-0.7	-0.5	0.1
Happiness	0.3	0.4	0.9	0.7	0.5	0.6	0.8	0.6	0.5	0.9	0.7	0.7	0.6	0.7	0.3
Prospective memory result	0.3	0.4	1.7	0.0	0.8	-0.6	-0.3	-0.3	-0.0	-0.7	-0.1	-0.1	-0.8	-1.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.6	0.2	-0.6	-0.7	-0.5	-0.7	-1.0	-0.4	-1.0	-0.5	-0.9	0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	2.9	0.6	1.7	0.7	0.5	0.5	0.4	0.6	0.4	0.6	0.6	1.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.2	0.2	1.5	0.3	0.5	0.7	0.8	0.5	0.3	0.5	0.3	0.1	0.3
Average weekly red wine intake	0.3	0.4	0.9	-0.7	-0.7	-0.6	-0.6	-0.4	-0.7	-0.8	-0.6	-0.9	0.3	-0.4	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	1.0	0.6	0.6	0.6	0.7	0.4	0.7	0.6	0.5	0.5	0.4	0.4
Breast cancer (self-reported)	0.3	0.3	0.9	-0.6	-0.7	-0.3	-0.5	-0.3	-0.7	-0.3	-0.4	-0.3	-0.8	-0.4	-0.9
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	-0.8	-0.6	-0.5	-0.4	-0.6	-0.5	-0.5	-0.3	-0.3	-0.4	-1.1	-0.2
Medication: Bendroflumethiazide	0.3	0.5	1.8	0.1	-0.7	-0.5	-0.3	-0.8	-0.5	-0.2	-0.6	0.0	-1.4	-1.2	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.9	0.2	0.2	0.5	0.4	0.9	0.5	0.5	0.8	0.3	0.3	-0.2
Age started oral contraceptive pill	0.3	0.3	2.3	-0.4	-1.5	-0.3	-0.2	-0.3	0.2	-0.6	0.0	-0.6	-0.2	-0.5	0.3
Commuting to job workplace: Cycle	0.3	0.3	0.7	-0.6	-0.2	-0.7	-0.6	-0.5	-0.9	-0.6	-0.7	-0.7	-0.2	-0.2	-0.5
Leg fat mass (left)	0.3	1.0	1.7	0.7	-0.5	1.1	1.1	1.0	1.2	0.6	1.2	0.8	1.3	0.8	1.3
Worry (Nagel 2018)	0.2	0.5	1.1	-0.3	-0.0	-0.7	-0.9	-0.6	-0.9	-0.7	-0.7	-0.5	-1.0	-1.0	-0.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.4	-0.9	-1.2	-0.4	-0.6	-0.4	0.2	-0.9	-0.5	-0.6	0.1	-0.4	-0.5
Hypothyroidism (self reported)	0.2	0.5	2.2	0.8	1.5	0.6	0.4	0.7	0.6	0.5	0.5	0.6	0.1	0.1	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	2.1	0.7	1.4	0.2	0.2	0.3	-0.2	0.5	-0.1	0.7	-0.2	-0.3	0.6
Hearing difficulty/problems: Yes	0.2	0.3	1.4	0.1	1.2	-0.0	-0.4	-0.1	-0.8	-0.4	-0.2	-0.2	-0.3	-0.4	1.1
Relative age of first facial hair	0.2	0.4	1.3	0.9	0.7	0.4	0.6	0.6	0.3	1.1	0.3	1.1	-0.1	0.4	-0.4
Diabetes (mother)	0.2	0.2	1.6	0.1	-1.3	-0.2	-0.2	-0.5	-0.4	-0.2	-0.4	0.0	-0.1	-0.4	0.0
Maternal smoking around birth	0.2	0.3	0.9	0.9	0.9	0.3	0.4	0.5	1.0	0.2	0.5	0.3	0.5	0.3	-0.0
Qualifications: CSEs or equivalent	0.2	0.2	1.8	-0.2	1.4	0.1	0.1	0.2	-0.3	0.1	0.1	0.4	-0.1	-0.2	0.5
Body mass index (BMI)	0.2	0.7	1.8	0.2	-0.4	1.0	0.9	0.8	0.8	0.5	0.9	0.8	1.1	0.8	1.4
Nervous feelings	0.2	0.4	0.9	-0.1	0.5	-0.5	-0.8	-0.4	-1.0	-0.6	-0.7	-0.4	-1.0	-0.9	0.1
Pain all over the body in last month	0.2	0.3	0.8	-0.1	-0.1	0.7	0.3	0.6	-0.2	0.3	0.4	0.3	0.7	0.9	0.7
Medication: Ramipril	0.2	0.2	1.3	0.5	0.3	0.5	0.2	0.3	-0.3	0.3	0.3	0.4	0.5	0.4	1.2
Medication: Simvastatin	0.2	0.3	1.1	0.5	-0.2	0.3	0.6	0.3	1.1	0.8	0.5	1.0	0.4	0.2	0.4
Neuroticism score	0.2	0.5	1.1	0.1	-0.5	-0.7	-0.9	-0.5	-0.7	-0.5	-0.7	-0.5	-1.1	-1.1	-0.6
Arm fat percentage (right)	0.2	0.7	2.5	-1.0	-1.6	-0.5	-0.7	-0.6	-0.7	-1.1	-0.6	-0.8	-0.2	-0.6	0.4
Illnesses of mother	0.2	0.3	1.5	0.5	1.2	0.5	0.5	0.7	0.3	0.6	0.4	0.5	0.1	-0.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	-0.6	-0.2	-0.8	-0.8	-0.7	-0.7	-0.8	-0.8	-1.1	-0.1	-0.4	-0.7
Arm fat mass (right)	0.2	0.7	1.7	0.4	-0.7	0.9	0.8	0.8	0.6	0.4	0.9	0.5	1.2	0.7	1.3
Exposure to tobacco smoke at home	0.2	0.2	1.8	0.3	1.4	0.0	0.1	0.2	0.1	0.3	-0.0	0.0	-0.7	-0.7	0.1
Pulse wave reflection index	0.2	0.2	0.6	-0.0	0.0	-0.4	-0.6	-0.3	-0.6	-0.6	-0.3	-0.7	-0.3	-0.8	-0.0
Blood clot in the leg (DVT)	0.2	0.2	0.8	-0.4	-0.3	-0.5	-0.4	-0.3	0.0	0.0	-0.6	0.1	-0.5	-0.5	-0.9
Headache pain in last month	0.2	0.4	1.1	-1.1	0.2	-0.3	-0.6	-0.6	-0.9	-0.5	-0.5	-0.6	-0.9	-0.7	0.3
Birth weight	0.2	0.5	1.6	0.0	-0.5	0.6	0.8	0.1	0.7	0.4	0.6	0.6	1.2	1.3	-0.1
Body fat percentage	0.2	0.7	3.2	-0.8	-1.8	-0.5	-0.6	-0.6	-0.3	-1.2	-0.4	-1.0	-0.0	-0.6	0.1
Leg fat percentage (right)	0.2	0.9	3.1	-1.0	-1.8	-0.7	-0.8	-0.8	-0.3	-1.4	-0.6	-1.0	-0.6	-1.0	0.1
Exposure to tobacco smoke outside home	0.2	0.3	1.0	0.7	-0.1	0.5	0.6	0.3	0.8	0.4	0.5	0.6	0.2	0.2	1.0
Leg fat mass (right)	0.2	0.6	1.5	0.4	-0.6	0.9	0.8	0.7	0.8	0.3	0.8	0.6	1.1	0.6	1.2
Number of full sisters	0.2	0.3	0.9	0.6	-0.9	0.4	0.6	0.3	0.4	0.6	0.5	0.8	0.4	0.2	-0.2
Chest pain or discomfort	0.2	0.2	1.0	-0.8	0.6	0.5	0.2	-0.1	-0.2	-0.3	0.5	-0.0	0.2	0.4	1.0
Hypertension (Self-reported)	0.2	0.6	1.2	-0.3	-0.8	-0.8	-0.6	-1.1	-0.9	-0.4	-0.9	-0.2	-1.1	-0.9	-1.1
Arm fat percentage (left)	0.2	0.9	3.1	-1.2	-1.8	-0.7	-0.8	-0.8	-0.8	-1.3	-0.7	-1.1	-0.2	-0.7	0.3
Medication: Gliclazide	0.2	0.3	0.5	0.2	-0.6	0.4	0.7	0.2	0.7	0.3	0.6	0.3	0.6	0.6	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.0	0.4	0.4	0.2	0.4	0.2	0.3	0.2	0.4	0.7	0.7	0.7
Guilty feelings	0.2	0.3	1.2	0.1	1.1	-0.0	-0.3	-0.1	-0.2	-0.7	-0.1	-0.6	-0.4	-0.5	0.7
Medication: Paracetamol	0.2	0.3	2.0	-0.9	-0.2	0.1	-0.2	-0.1	-0.1	-0.3	0.0	-0.4	-0.2	-0.3	1.4
Alcohol drinker status: Never	0.2	0.3	1.2	-0.1	0.8	-0.5	-0.4	-0.0	-0.3	-0.1	-0.4	0.1	-0.5	-0.8	-1.1
Leg fat percentage (left)	0.2	0.6	3.3	-0.7	-1.8	-0.4	-0.3	-0.6	0.2	-1.0	-0.2	-0.7	-0.3	-0.8	0.0
Fractured/broken bones in last 5 years	0.2	0.2	0.8	-0.2	0.0	-0.6	-0.4	-0.6	-0.9	-0.1	-0.5	-0.3	-0.6	-0.6	-0.3
Myopia	0.2	0.3	0.8	-0.5	-0.9	-0.4	-0.5	-0.5	-0.6	-0.6	-0.5	-0.3	-0.4	-0.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.3	-0.1	-0.6	-0.4	-0.3	0.0	-0.1	-0.6	-0.1	-0.7	-0.6	-0.9
Pack years of smoking	0.2	0.3	0.9	-0.9	-0.2	-0.6	-0.2	-0.6	-0.0	-0.8	-0.1	-0.8	-0.2	-0.5	-0.3
Bipolar Disorder (2018)	0.1	0.2	0.5	0.6	-0.1	0.3	0.3	0.7	0.4	0.6	0.2	0.6	0.6	0.7	-0.2
Crohns Disease (2017)	0.1	0.3	1.4	-0.8	-1.2	-0.3	-0.2	-0.0	0.4	-0.8	-0.0	-0.7	0.1	-0.4	0.1
Ovarian Cancer	0.1	0.1	0.5	0.3	-0.7	0.2	0.3	0.2	0.6	0.1	0.2	0.1	-0.0	0.0	0.6
Prostate Cancer	0.1	0.2	0.5	0.7	0.2	0.3	0.4	0.2	0.5	0.4	0.4	0.6	0.6	0.3	0.1
Fasting Glucose	0.1	0.1	0.5	-0.0	-0.3	0.1	0.1	0.1	-0.1	0.4	0.0	0.7	0.1	-0.1	-0.1
HDL Cholesterol	0.1	0.1	0.5	0.1	-0.5	0.2	0.4	0.2	0.4	0.1	0.4	0.0	0.4	0.2	0.7
Triglycerides	0.1	0.1	0.4	0.2	0.6	0.1	0.2	0.5	0.3	0.3	0.1	0.6	0.2	0.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.1	-0.6	0.3	0.1	0.4	-0.1	-0.1	0.2	0.1	0.2	-0.0	-0.7
Blood White Count	0.1	0.4	0.9	0.8	0.9	0.5	0.4	0.9	0.6	0.4	0.6	0.3	0.6	0.6	1.0
Waist Hip Ratio (WHR)	0.1	0.4	2.0	1.4	0.5	0.2	0.7	0.6	0.5	0.8	0.5	0.6	0.3	0.3	-0.1
Cardiovascular Disease	0.1	0.2	0.7	0.8	0.1	-0.0	0.2	0.2	-0.2	0.7	-0.1	0.9	-0.1	-0.1	-0.5
Tanning	0.1	0.8	3.0	0.5	1.7	0.9	1.0	0.5	1.0	0.6	1.0	0.8	0.5	0.6	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	1.1	0.2	-0.2	-0.2	-0.1	-0.1	-0.3	-0.0	-0.0	-0.4	-0.9	-1.0	-0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	-0.0	-0.7	0.3	0.3	0.1	0.5	-0.0	0.4	0.1	0.5	0.5	-0.2
Vitamin and mineral supplements	0.1	0.1	0.5	-0.7	-0.4	-0.3	-0.4	-0.2	-0.1	-0.3	-0.3	-0.1	-0.2	-0.3	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	-0.5	0.4	-0.1	0.2	-0.2	0.3	-0.3	0.4	-0.4	0.2	-0.0	0.2
Trunk fat percentage	0.1	0.5	3.0	-0.7	-1.7	-0.4	-0.5	-0.4	-0.2	-1.0	-0.3	-1.0	0.3	-0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.3	0.1	-0.0	0.0	-0.0	0.5	0.1	0.1	0.2	-0.5	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.0	0.6	0.4	0.4	0.5	0.1	0.5	0.4	0.5	0.4	0.3	0.1
High blood pressure	0.1	0.4	0.9	-0.1	-1.0	-0.5	-0.4	-0.8	-0.6	-0.2	-0.6	-0.0	-0.6	-0.5	-0.8
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.1	0.5	0.0	0.5	0.1	0.2	0.0	0.6	-0.1	0.0	-0.6	0.2
Supplements: Glucosamine	0.1	0.1	1.3	-0.5	-1.1	-0.1	0.2	-0.1	0.1	0.3	0.0	-0.1	-0.1	0.1	-0.3
High blood pressure (mother)	0.1	0.2	0.7	0.0	-0.5	-0.1	-0.4	-0.1	-0.7	0.1	-0.3	-0.2	0.1	0.2	-0.8
Trunk fat mass	0.1	0.5	1.6	0.2	-1.0	0.6	0.6	0.5	0.6	0.1	0.7	0.1	1.3	0.6	0.9
Number of incorrect matches in round	0.1	0.2	0.6	-0.8	0.1	-0.2	-0.3	-0.1	0.3	-0.6	-0.1	-0.6	-0.4	-0.7	0.4
Qualifications: None of the above	0.1	0.1	0.4	-0.0	-0.7	-0.1	0.2	-0.1	0.4	-0.2	0.3	-0.3	0.5	0.2	-0.3
Diabetes (self-reported)	0.1	0.1	0.3	0.3	-0.4	0.3	0.6	0.2	0.3	0.4	0.4	0.4	-0.1	-0.3	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.1	-0.1	0.3	0.6	0.1	0.5	0.4	0.4	0.5	-0.1	0.0	0.3
Worrier / anxious feelings	0.1	0.2	0.5	0.4	-0.2	0.4	0.5	0.4	0.4	0.7	0.5	0.4	-0.1	0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.6	-0.6	0.2	-0.0	-0.1	-0.3	-0.3	-0.1	-0.2	-0.3	-0.8	-0.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.0	-0.6	-0.2	-0.7	-0.5	-0.5	-0.2	-0.5	-0.5	-0.8	0.0	-0.5	-1.0
Lung cancer (father)	0.1	0.1	0.3	0.6	0.1	0.2	0.4	0.3	0.4	0.3	0.2	0.2	0.5	0.1	0.1
Tense / ‘highly strung’	0.1	0.1	0.6	0.7	0.0	0.2	0.0	0.3	0.3	-0.1	0.3	-0.0	-0.2	-0.4	0.8
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.1	0.6	0.1	0.4	0.4	0.3	0.2	0.5	0.1	0.8	-0.1	-0.6
Loud music exposure frequency	0.1	0.1	0.4	-0.0	-0.5	-0.2	-0.0	0.0	-0.5	0.1	-0.2	0.2	0.4	0.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.0	0.1	-0.3	-0.6	-0.3	-0.7	-0.2	-0.8	0.0	-0.7	-0.4	-0.1
Gout (self-reported)	0.1	0.1	0.3	0.3	0.1	0.1	0.1	0.3	0.1	0.5	0.2	-0.0	0.2	0.0	0.5
Comparative body size at age 10	0.1	0.4	1.0	0.0	0.1	0.3	0.6	0.5	0.9	0.5	0.5	0.7	1.0	0.9	-0.5
Qualifications: College or University degree	0.1	0.3	0.8	0.2	-0.9	-0.4	-0.3	-0.6	-0.4	0.2	-0.4	0.1	-0.8	-0.5	-0.9
Emphysema/chronic bronchitis	0.1	0.1	0.7	0.1	-0.4	0.1	0.2	0.1	0.8	0.1	0.4	0.4	0.4	-0.1	-0.2
Migraine (self-reported)	0.1	0.1	0.4	-0.4	-0.2	-0.4	-0.2	-0.1	-0.3	-0.4	-0.1	-0.6	-0.3	-0.6	0.2
Medication: Allopurinol	0.1	0.1	0.4	0.1	0.4	-0.0	-0.1	0.1	-0.6	0.3	-0.1	-0.1	0.2	0.1	0.7
Whole body fat mass	0.1	0.5	1.4	0.3	-1.0	0.7	0.6	0.6	0.7	0.2	0.8	0.3	1.2	0.6	1.0
Alcohol intake frequency.	0.1	0.1	0.5	-0.7	-0.4	-0.0	0.1	0.4	0.2	-0.2	0.4	-0.2	0.2	-0.5	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.6	-0.1	-0.8	-0.2	-0.2	-0.1	0.4	-0.1	-0.2	-0.0	0.2	0.1	-0.7
Loneliness, isolation	0.1	0.2	0.7	0.9	-0.1	0.4	0.4	0.5	0.3	0.5	0.4	0.2	0.2	0.3	0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.8	-0.3	-0.3	-0.2	-0.3	-0.0	-0.7	0.1	-0.8	-0.1	-0.6	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.2	-0.6	0.2	0.4	-0.0	0.2	0.3	0.3	0.3	-0.2	-0.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	1.2	-0.2	0.1	-0.0	-0.2	-0.4	-1.1	-0.3	-0.2	0.3	-0.4	-0.2	-0.0
Arm fat mass (left)	0.1	0.4	1.1	0.1	-0.9	0.7	0.6	0.5	0.4	0.1	0.7	0.2	1.0	0.5	1.1
High cholesterol (Self-reported)	0.1	0.2	0.9	0.6	0.1	-0.0	0.5	0.1	0.9	0.4	0.4	0.7	0.1	-0.4	0.2
Medication: Atorvastatin	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.4	-0.3	-0.3	-0.6	-0.5	-0.4	-0.2	-0.6	-0.0
Ever smoked	0.1	0.1	0.4	-0.2	-0.1	0.2	0.0	-0.4	0.1	-0.5	-0.0	-0.3	0.4	0.6	-0.0
Average weekly beer plus cider intake	0.1	0.2	0.5	0.6	0.3	0.4	0.0	0.3	0.3	0.1	0.1	-0.0	0.3	0.6	0.7
Risk taking	0.1	0.2	0.6	0.4	-0.3	0.0	0.3	0.2	0.8	0.2	0.2	0.3	0.4	0.1	-0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	1.0	-0.1	1.0	0.3	0.1	0.7	0.5	-0.0	0.5	-0.4	0.5	0.4	0.5
Supplements: Calcium	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.5	-0.1	-0.6	-0.4	-0.3	-0.5	-0.3	-0.3	0.6
Heart disease (siblings)	0.1	0.2	0.7	0.1	-0.8	-0.5	-0.1	-0.4	0.1	-0.2	0.0	-0.4	-0.5	-0.6	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.2	-0.4	0.1	0.0	0.3	-0.0	-0.2	0.3	-0.2	0.7	0.3	0.5
Depression (Nagel 2018)	0.0	0.1	0.2	0.1	-0.1	-0.2	-0.1	-0.0	0.1	-0.1	0.1	-0.5	-0.3	-0.5	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.3	-0.1	-0.4	0.0	-0.3	-0.2	0.2	-0.2	-0.3	0.2	0.1	0.0	-0.5
Neuroticism (2016)	0.0	0.0	0.2	0.2	0.4	-0.0	-0.3	0.3	0.0	-0.1	-0.2	-0.1	0.0	-0.0	-0.0
Rheumatoid Arthritis	0.0	0.1	0.2	-0.1	-0.0	-0.0	0.1	-0.1	-0.3	-0.2	0.1	-0.3	-0.1	-0.4	0.4
Blood Red Count	0.0	0.1	0.5	0.1	-0.6	-0.0	0.0	0.2	-0.2	-0.1	0.3	-0.4	0.1	-0.3	0.7
Lung FEV1/FVC ratio	0.0	0.2	0.8	-0.3	0.9	-0.3	0.0	-0.2	-0.1	-0.4	-0.0	-0.5	-0.1	-0.7	0.1
Hair Pigment	0.0	0.2	0.8	0.5	0.0	0.0	-0.1	0.1	-0.7	0.1	-0.2	-0.4	-0.6	0.9	0.2
Hand grip strength (left)	0.0	0.1	0.7	0.3	-0.1	-0.1	-0.2	-0.2	0.2	-0.2	-0.1	-0.0	0.1	-0.1	-0.8
Sensitivity / hurt feelings	0.0	0.1	0.4	-0.4	-0.6	-0.1	-0.4	-0.1	-0.1	-0.4	-0.2	-0.3	-0.2	-0.2	-0.1
Hand grip strength (right)	0.0	0.1	0.5	-0.0	-0.0	-0.1	-0.2	-0.1	0.0	-0.1	-0.1	0.0	0.2	0.2	-0.7
Age when periods started (menarche)	0.0	0.1	0.4	-0.4	-0.2	-0.4	-0.1	-0.6	0.3	0.0	-0.3	0.0	-0.3	-0.3	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.3	-0.0	0.5	0.1	-0.0	0.1	-0.1	0.0	0.1	-0.2	0.2	-0.0	-0.3
Forced vital capacity (FVC)	0.0	0.1	0.7	-0.1	-0.4	-0.3	-0.1	-0.2	0.2	-0.2	-0.1	-0.4	0.4	0.1	-0.8
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.2	-0.3	0.2	-0.3	0.0	0.1	0.4	-0.0	0.0	-0.1	0.2	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.1	0.5	0.2	-0.2	-0.1	-0.2	-0.1	0.1	-0.2	-0.1	-0.5	0.7	0.4	-0.3

Hub : Genes

LBX2

Models

Trait associations