TWAS hub - DGUOK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0209	0.0107	0.0180	0.002	0.004	0.009	0.007	0.003	0.056	0.0140	0.00054	0.002	0.028
2	TCGA	Breast Invasive Carcinoma	0.0213	0.0125	0.0062	0.004	0.008	0.007	NA	0.004	0.050	0.0086	0.00900	NA	0.053
3	TCGA	Prostate Adenocarcinoma	0.0410	0.0211	0.0043	-0.002	0.008	-0.003	NA	-0.002	0.750	0.0440	0.98000	NA	0.690

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Guilty feelings	5.0	7.5	8.1	2.8	2.7	2.7
Alcohol drinker status: Never	4.6	5.5	8.4	-1.6	-2.9	-2.4
Bipolar Disorder (2011)	4.1	4.0	7.1	-0.8	-2.0	-2.7
Medication: Ventolin 100micrograms inhaler	4.1	5.3	7.7	2.8	2.4	1.5
Schizophrenia vs Biploar Disorder	3.3	4.4	7.4	0.5	2.3	2.7
Eye problems/disorders: Glaucoma	3.2	3.8	11.3	3.4	0.1	0.4
Glaucoma (self-reported)	3.0	3.5	5.8	2.4	1.6	1.5
Severe depression (siblings)	2.6	2.9	6.8	-2.6	0.0	-1.4
Financial situation satisfaction	2.6	3.3	5.1	1.1	1.9	2.3
Average weekly fortified wine intake	2.5	3.0	7.5	2.7	1.0	0.7
Number of full sisters	2.5	3.1	6.8	1.0	2.6	1.2
Illnesses of siblings: Diabetes	2.4	2.9	6.1	1.4	0.9	2.5
Mean Putamen Volume	2.3	2.7	4.2	-1.6	1.1	2.0
Ever taken oral contraceptive pill	2.2	2.4	5.0	-0.6	-2.2	-1.4
Mineral and other dietary supplements	2.1	2.8	4.8	-1.7	-0.8	-2.2
Blood Platelet Count	2.0	23.4	41.1	-6.4	-2.5	-4.8
Chest pain or discomfort	1.8	2.7	7.3	0.7	2.7	0.5
Heart attack/myocardial infarction (self-reported)	1.8	2.3	4.2	1.4	1.0	2.1
Bipolar Disorder (2018)	1.7	2.7	3.5	-1.1	-1.9	-1.9
Neuroticism (Nagel 2018)	1.7	4.1	7.2	1.9	1.2	2.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	2.8	-1.7	1.0	-1.5
Heart attack	1.7	2.2	4.2	1.2	1.0	2.0
Neuroticism score	1.7	3.6	5.9	1.5	1.6	2.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	3.6	0.1	-1.9	-1.7
Neuroticism	1.6	3.9	5.9	1.7	1.6	2.4
Birth weight of first child	1.6	2.9	7.1	0.9	0.9	2.7
Number of children fathered	1.6	1.8	3.5	-1.9	-1.4	-0.3
Angina (self-reported)	1.6	2.2	4.3	2.1	1.1	0.9
Average weekly champagne plus white wine intake	1.6	2.1	3.0	1.7	1.3	1.4
Depressed Affect (Nagel 2018)	1.5	3.1	6.4	1.5	0.9	2.5
Coronary Artery Disease (CAD)	1.5	1.8	4.1	0.5	1.0	2.0
Angina	1.5	2.0	3.8	1.9	1.1	0.9
Multivitamins +/- minerals	1.5	1.9	2.9	1.7	-0.1	1.6
Hair/balding pattern: Pattern 3	1.5	2.2	3.3	0.2	-1.8	-1.8
Pulse rate, automated reading	1.5	4.9	8.8	-1.1	-2.2	-3.0
Family relationship satisfaction	1.5	1.8	4.8	0.6	0.4	2.2
Friendships satisfaction	1.5	1.9	4.2	0.7	0.9	2.1
Commuting to job workplace: Walk	1.5	1.6	3.8	-0.9	0.6	1.9
Medication: Bendroflumethiazide	1.5	2.3	3.3	1.4	1.8	1.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.1	1.3	-1.5	-0.7
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.8	1.7	1.2	0.5
Breastfed as a baby	1.4	1.8	4.7	-0.7	2.2	0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.4	0.2	2.5	0.5
Health satisfaction	1.4	1.8	2.8	1.7	0.6	1.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.2	-1.3	-1.5	-1.2
Major Depression (MDD)	1.3	1.6	3.9	-0.2	1.0	2.0
HbA1C	1.3	1.4	3.6	1.9	-0.2	0.8
Lupus	1.3	2.0	4.4	-2.1	0.7	1.1
Maternal smoking around birth	1.3	1.8	2.9	-1.7	-1.6	0.0
Blood clot in the leg (DVT)	1.3	1.7	2.5	-1.0	-1.6	-1.2
Medication: Aspirin	1.3	1.6	2.5	1.6	0.1	1.6
Basal cell carcinoma (self-reported)	1.3	1.5	2.4	-1.3	-0.6	-1.5
Worry (Nagel 2018)	1.2	2.5	3.9	1.7	0.8	2.0
Medication: Atenolol	1.2	1.5	2.2	1.2	1.0	1.5
Arm fat percentage (right)	1.2	4.6	13.0	3.6	0.8	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.7	-1.0	-1.7	-0.7
Asthma	1.2	2.3	6.7	-0.4	2.6	0.2
Hair/balding pattern: Pattern 4	1.2	3.0	8.7	-2.9	-0.4	0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.6	1.6	1.2	0.3
Mood swings	1.2	2.1	4.4	1.1	0.8	2.1
Osteoporosis (self-reported)	1.2	1.5	4.0	-2.0	0.0	0.8
Alcohol drinker status: Previous	1.2	1.4	3.2	0.8	-0.5	-1.8
Body Mass Index (BMI) (2010)	1.1	1.5	3.2	1.8	-1.1	0.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.1	1.3	1.0	1.4
Medication: Metformin	1.1	1.5	2.9	1.7	-1.1	0.6
Townsend deprivation index at recruitment	1.1	1.5	2.3	-1.3	1.5	0.7
Taking other prescription medications	1.1	1.8	4.6	0.5	0.7	2.1
Exposure to tobacco smoke outside home	1.1	1.5	2.9	0.2	1.3	1.7
Comparative body size at age 10	1.1	2.9	4.7	2.2	1.3	1.6
Migraine (self-reported)	1.1	1.4	3.0	-0.4	-1.7	-1.0
Alcohol intake frequency.	1.1	2.6	5.0	0.0	-1.7	-2.2
Arm fat percentage (left)	1.1	4.6	12.9	3.6	0.9	0.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.8	-2.2	-0.3	-0.7
Medication: Aspirin	1.1	1.5	2.5	1.6	-0.2	1.3
Waist Hip Ratio (WHR)	1.0	4.3	6.7	-2.6	-1.9	-1.7
Diabetes (father)	1.0	1.2	2.9	0.1	0.9	1.7
Body mass index (BMI)	1.0	4.5	8.9	3.0	2.0	0.8
Impedance of leg (left)	1.0	4.7	7.1	-2.7	-2.4	-1.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.4	1.6	1.2	0.4
Pulse rate	1.0	1.7	4.4	0.6	-0.6	-2.1
Peak expiratory flow (PEF)	1.0	2.4	4.0	-1.4	-2.0	-1.0
Illnesses of father: Heart disease	1.0	1.3	3.0	-0.5	-1.7	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.5	-1.6	-0.9	-0.5
Asthma (self-reported)	1.0	1.9	5.8	-0.1	2.4	0.1
Osteoarthritis (self-reported)	1.0	1.3	2.6	1.6	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	2.4	-1.3	-1.5	-1.5
Medication: Paracetamol	1.0	1.6	2.7	1.6	-1.1	-0.9
Number of operations (self-reported)	1.0	1.5	2.3	-1.5	0.4	-1.4
Risk taking	1.0	1.4	1.8	-1.3	1.2	-1.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.1	-0.9	-1.4	0.9
Age started oral contraceptive pill	1.0	1.3	2.0	-1.4	-1.4	0.1
Commuting to job workplace: Cycle	1.0	1.2	1.9	0.6	1.4	1.1
Fasting Glucose	0.9	1.0	2.5	-0.0	-1.6	-0.8
HDL Cholesterol	0.9	1.5	2.2	1.5	-1.1	-1.1
Respiratory disease	0.9	2.0	5.7	-0.5	2.4	-0.4
Type 2 Diabetes (T2D) (2018)	0.9	1.8	3.0	1.5	-1.7	0.2
Chronotype (morning person)	0.9	2.0	3.7	-1.9	-1.3	-0.8
Impedance of leg (right)	0.9	4.4	6.3	-2.5	-2.4	-1.1
Diabetes (self-reported)	0.9	1.4	3.5	0.7	-1.9	0.4
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	7.0	-1.3	-2.6	0.2
Arm fat mass (right)	0.9	3.5	9.7	3.1	0.5	0.8
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.0	0.2	1.0	1.4
Arm fat mass (left)	0.9	3.8	10.0	3.2	0.7	0.9
Hearing aid user	0.9	1.0	2.6	1.6	-0.3	0.6
Ovarian Cancer	0.8	1.0	1.8	1.1	-0.2	-1.4
Blood Eosinophil Count	0.8	6.2	11.8	1.7	2.0	3.4
Number of treatments/medications taken	0.8	1.4	2.9	1.7	-0.7	1.0
Vitamin and mineral supplements	0.8	1.0	2.0	-1.4	-0.3	-1.0
Supplements: Glucosamine	0.8	1.0	1.3	1.1	-0.7	1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	0.3	0.5	1.7
Number of live births	0.8	1.2	2.6	0.4	0.9	1.6
Prospective memory result	0.8	1.0	2.1	1.5	-0.6	-0.8
Lung cancer (father)	0.8	1.0	1.6	-1.1	-1.3	-0.3
Tense / ‘highly strung’	0.8	1.4	3.2	0.8	0.4	1.8
Pulse wave reflection index	0.8	0.9	2.6	-0.1	0.5	1.6
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.7	1.6	0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.2	-0.4	-1.5	-0.7
Eye problems/disorders: None of the above	0.8	0.9	1.6	-0.7	-0.8	1.2
Emphysema/chronic bronchitis	0.8	0.9	2.5	-0.5	-0.0	-1.6
Whole body fat mass	0.8	3.2	8.5	2.9	0.3	1.0
Leg fat mass (right)	0.8	3.0	7.0	2.6	0.6	1.3
Loneliness, isolation	0.8	1.1	1.8	1.1	0.4	1.4
Breast cancer (self-reported)	0.8	0.9	1.4	0.9	0.7	-1.2
Miserableness	0.8	1.4	2.7	0.8	0.8	1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	-0.7	-0.8	-1.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.7	1.3	0.4	1.1
Heart disease (siblings)	0.8	1.0	1.5	-1.2	-1.2	-0.2
Age at First Birth	0.7	1.0	1.7	-0.5	1.0	1.3
Supplements: Zinc	0.7	0.7	2.2	0.0	0.2	-1.5
Trunk fat percentage	0.7	2.9	8.8	3.0	-0.1	0.1
Current tobacco smoking	0.7	1.1	2.8	1.7	0.2	-0.7
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.3	1.0	0.2
Trunk fat mass	0.7	2.9	8.1	2.8	-0.2	0.8
Hearing difficulty/problems with background noise	0.7	1.1	2.6	1.6	0.5	0.7
Illnesses of siblings	0.7	0.9	2.5	0.3	0.5	-1.6
Hip circumference	0.7	2.8	6.6	2.6	0.2	1.4
Body fat percentage	0.7	2.9	8.5	2.9	0.2	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	2.1	1.4	0.7	-1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	-0.3	-1.3	-0.9
Medication: Ibuprofen	0.7	0.8	1.3	1.1	-1.0	-0.2
Medication: Allopurinol	0.7	0.9	1.4	1.2	0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.0	0.7	1.0	-0.8
Cholesterol lowering medication	0.7	1.0	1.6	-0.4	1.3	-1.1
Impedance of whole body	0.7	3.7	6.5	-1.5	-2.5	-1.6
Leg fat mass (left)	0.7	2.5	6.0	2.4	0.5	1.2
Bipolar Disorder or Schizophrenia	0.6	1.4	3.0	-1.7	-1.0	-0.3
Crohns Disease (2012)	0.6	1.0	2.7	1.6	0.4	-0.5
Rheumatoid Arthritis	0.6	0.9	2.6	1.6	-0.0	-0.2
Blood White Count	0.6	4.7	12.4	3.5	-1.2	-0.6
Lung FEV1/FVC ratio	0.6	3.1	8.4	-0.2	-2.9	-0.9
Medication for hormone replacement therapy	0.6	0.7	1.2	0.7	-0.7	1.1
Pack years adult smoking proportion	0.6	0.9	1.6	-0.8	-0.6	-1.3
Serious illness, injury or assault to yourself	0.6	0.8	1.8	-0.7	-0.2	-1.3
Number of incorrect matches in round	0.6	1.0	1.8	1.4	-0.1	-1.0
Pain all over the body in last month	0.6	0.7	1.4	1.2	0.2	0.8
Fluid intelligence score	0.6	1.2	2.5	-1.6	-0.9	-0.4
Weight	0.6	3.1	5.5	2.4	0.7	1.8
Impedance of arm (right)	0.6	2.8	7.2	-0.3	-2.7	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.8	-1.0	-2.2	0.1
Pulse wave Arterial Stiffness index	0.6	0.6	1.0	0.7	-0.6	1.0
High blood pressure (siblings)	0.6	0.9	1.3	1.2	0.1	1.1
Pulse wave peak to peak time	0.6	0.7	1.4	-0.8	0.3	-1.2
Shortness of breath walking on level ground	0.6	0.8	1.8	1.4	0.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.2	1.3	-0.5
Comparative height size at age 10	0.6	3.1	4.4	-2.1	-1.6	1.6
Leg pain on walking	0.6	0.8	2.1	1.4	0.6	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.8	1.7	1.3	0.7	-0.4
Myopia	0.6	0.9	2.4	0.3	0.6	1.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.8	0.0	0.5	1.3
Depression (Nagel 2018)	0.5	0.7	1.1	1.0	-0.4	1.0
Schizophrenia (2018)	0.5	1.1	1.8	-1.3	0.1	1.3
Reaction Time	0.5	1.0	2.5	0.7	-1.6	0.3
Prostate Cancer	0.5	0.7	1.3	-1.1	0.4	-0.8
Sensitivity / hurt feelings	0.5	0.9	2.5	0.3	1.6	0.3
Leg fat-free mass (left)	0.5	2.6	4.1	2.0	0.4	1.9
Leg predicted mass (left)	0.5	2.5	4.1	2.0	0.2	1.8
Had menopause	0.5	0.6	1.6	-1.3	-0.3	0.2
Forced vital capacity (FVC)	0.5	1.9	3.3	-1.5	-1.8	0.5
Medication: Cholesterol lowering	0.5	0.8	1.3	0.4	-1.0	1.2
Standing height	0.5	5.3	9.1	-1.0	-3.0	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	0.3	0.3	1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.4	0.1	0.1	-1.5
Birth weight	0.5	1.1	1.9	-1.4	-0.8	0.9
Leg fat percentage (right)	0.5	1.9	4.5	2.1	0.7	0.9
Number of full brothers	0.5	0.6	1.4	0.5	1.2	0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.4	-1.2	1.1	-0.3
Neck or shoulder pain in last month	0.5	0.8	1.1	-1.0	1.0	0.5
Medication: Omeprazole	0.5	0.6	1.1	0.6	0.7	1.0
Mean time to correctly identify matches	0.5	1.0	1.3	0.7	-1.2	1.1
Age at last live birth	0.5	0.7	2.0	1.4	0.0	0.0
Smoking status: Previous	0.5	0.8	1.4	-0.9	1.2	0.3
Ever had bowel cancer screening	0.5	0.6	0.9	-0.4	-0.9	-0.9
Diabetes diagnosed by doctor	0.5	0.9	2.2	0.5	-1.5	0.4
Smoking status: Current	0.5	0.8	2.0	1.4	0.2	-0.6
Leg predicted mass (right)	0.5	2.5	3.8	1.9	0.4	2.0
Leg fat percentage (left)	0.5	1.6	3.9	2.0	0.6	0.9
Fractured/broken bones in last 5 years	0.5	0.6	0.9	-1.0	-0.8	0.5
Supplements: Calcium	0.5	0.5	0.8	0.9	0.8	0.2
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	0.1	0.7	1.0
Neuroticism (2016)	0.4	0.6	1.2	0.8	-0.3	1.1
Schizophrenia (2014)	0.4	0.8	1.6	-1.3	-0.4	0.9
Triglycerides	0.4	0.6	1.7	1.3	0.4	-0.1
Ulcerative Colitis	0.4	0.6	1.0	-0.6	-0.6	-1.0
Blood Red Count	0.4	4.1	10.0	3.2	0.7	1.4
BMI	0.4	2.4	5.0	2.2	1.5	0.2
Hearing difficulty/problems: Yes	0.4	0.6	1.6	1.3	0.3	0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.0	0.1	1.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.4	-0.0	0.3	1.2
Alcohol usually taken with meals	0.4	0.6	1.7	-0.3	-0.4	-1.3
Nervous feelings	0.4	0.8	2.0	1.4	-0.6	0.2
Noisy workplace	0.4	0.5	0.8	-0.6	0.5	0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	0.9	0.4	1.1
Illnesses of mother	0.4	0.5	1.0	0.7	1.0	-0.4
Impedance of arm (left)	0.4	2.1	4.2	-0.1	-2.1	-1.4
Length of working week for main job	0.4	0.5	0.7	0.4	0.8	0.8
Loud music exposure frequency	0.4	0.5	1.2	-1.1	0.4	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.6	2.5	-1.3	-1.6	0.6
Worry too long after embarrassment	0.4	0.7	1.6	0.7	0.5	1.3
Medication: Blood pressure	0.4	0.7	1.9	-0.4	0.0	1.4
Heart disease (mother)	0.4	0.5	1.6	-0.1	-1.3	0.2
Suffer from ‘nerves’	0.4	0.7	1.3	0.6	0.6	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-0.0	0.7	-1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.8	0.6	-0.6
Supplements: Vitamin C	0.4	0.5	0.9	0.1	0.9	-0.7
Leg fat-free mass (right)	0.4	2.3	3.5	1.8	0.3	1.9
Eye problems/disorders: Cataract	0.4	0.5	1.1	-0.6	1.0	-0.0
Number of self-reported non-cancer illnesses	0.4	0.7	0.9	-0.5	0.9	-1.0
Medication: Blood pressure	0.4	0.7	1.3	1.1	0.3	0.8
Medication: Lisinopril	0.4	0.5	0.8	0.7	0.1	0.9
Illnesses of father: High blood pressure	0.4	0.5	1.3	-1.1	0.4	0.5
Basal metabolic rate	0.4	2.0	4.5	1.2	0.3	2.1
Average weekly beer plus cider intake	0.4	0.6	0.7	0.6	0.8	0.8
Pain experienced in last month	0.4	0.6	1.7	-0.2	-1.3	-0.2
Pack years of smoking	0.4	0.6	0.9	-0.6	-0.7	-0.9
Ulcerative Colitis (UC)	0.3	0.5	1.3	-0.4	-0.2	-1.1
LDL Cholesterol	0.3	0.5	0.9	-1.0	-0.3	-0.6
Height	0.3	5.3	8.0	0.4	-2.8	2.8
Tanning	0.3	3.3	6.7	-1.0	2.6	1.5
Diabetes (mother)	0.3	0.4	1.1	-0.4	-0.1	1.0
Fed-up feelings	0.3	0.5	1.3	-0.0	0.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.6	0.6	0.4	0.8
Age when periods started (menarche)	0.3	0.8	1.3	0.5	-0.9	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.6	-0.4	0.2	-1.3
High blood pressure	0.3	0.7	1.5	-0.6	-1.2	-0.6
Sitting height	0.3	2.5	4.2	-1.6	-2.0	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	-0.5	-0.5	-0.8
Past tobacco smoking	0.3	0.6	1.0	0.7	-1.0	0.3
Had other major operations	0.3	0.4	1.1	0.1	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	0.3	-0.6	-1.2
Allergy	0.3	0.6	0.9	0.9	-0.4	0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.7	-0.8	-0.5
Trunk fat-free mass	0.3	1.9	5.7	0.0	0.1	2.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	-0.2	1.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	0.7	-0.8	0.1
Depression (self-reported)	0.3	0.4	0.6	0.7	0.7	0.2
Trunk predicted mass	0.3	1.8	5.4	-0.0	-0.0	2.3
Headache pain in last month	0.3	0.6	1.1	-0.7	1.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	0.5	0.5	1.1
Arm fat-free mass (right)	0.3	1.7	4.6	0.4	0.4	2.1
Medication: Seretide 50 evohaler	0.3	0.4	1.0	-0.3	-0.2	-1.0
Arm predicted mass (right)	0.3	1.5	4.1	0.5	0.4	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.0	-0.1	-1.0	0.8
Whole body fat-free mass	0.3	1.9	5.2	0.7	0.2	2.3
Medication: Gliclazide	0.3	0.3	0.6	-0.8	-0.3	0.4
Whole body water mass	0.3	1.9	4.8	0.9	0.2	2.2
Medication: Atorvastatin	0.3	0.3	0.7	0.8	0.3	0.4
Arm fat-free mass (left)	0.3	1.6	4.4	0.5	0.0	2.1
Diastolic blood pressure, automated reading	0.3	1.0	2.4	0.5	-0.7	-1.5
Arm predicted mass (left)	0.3	1.5	4.1	0.5	0.1	2.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.5	-0.5	1.2	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.3	0.2	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.1	0.8	0.5
Crohns Disease (2017)	0.2	0.4	0.5	0.5	0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.5	-1.2	0.1	-0.2
Breast Cancer	0.2	0.5	0.5	-0.6	-0.7	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.7	-0.2	-0.4
Heel T-Score	0.2	1.7	3.4	-0.7	-1.1	-1.9
Hypothyroidism (self reported)	0.2	0.4	0.7	0.5	0.4	0.8
Relative age of first facial hair	0.2	0.3	0.9	0.3	-0.9	-0.2
Medication: Co-codamol	0.2	0.2	0.3	0.1	0.6	0.5
Stomach or abdominal pain in last month	0.2	0.3	0.4	-0.2	0.6	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.6	0.4	0.8
High blood pressure (mother)	0.2	0.2	0.4	-0.5	-0.7	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.4	-0.3	-0.5	0.6
Mouth/teeth dental problems	0.2	0.3	0.4	0.7	0.5	0.4
Time employed in main current job	0.2	0.2	0.7	0.3	0.8	-0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.5	-0.3	0.8
Happiness	0.2	0.2	0.3	-0.5	-0.5	0.1
Exposure to tobacco smoke at home	0.2	0.3	0.8	0.9	-0.2	0.0
Medication: Paracetamol	0.2	0.3	0.4	0.6	-0.5	-0.5
Gout (self-reported)	0.2	0.2	0.4	0.6	-0.1	0.6
Medication: Amlodipine	0.2	0.3	0.6	0.5	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.6	0.5	0.2
Age at first live birth	0.2	0.3	0.9	1.0	0.1	-0.1
Overall health rating	0.2	0.5	0.8	0.9	-0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.7	-0.3	-0.4
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.3	-0.4
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.5	0.8	0.3
Medication for cholesterol	0.2	0.3	0.5	-0.7	-0.6	-0.4
Wears glasses or contact lenses	0.2	0.2	0.5	-0.3	0.3	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.1	-0.3	-0.7
Ever smoked	0.2	0.4	0.6	-0.1	0.8	-0.7
Ever depressed for a whole week	0.2	0.3	0.4	0.0	-0.6	0.6
Unable to work because of sickness or disability	0.2	0.3	0.9	0.1	0.2	-0.9
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.1	0.5	-0.7
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.3	0.1	0.7
Systolic Blood Pressure	0.1	0.3	0.9	1.0	0.1	0.3
Smoking Status	0.1	0.3	0.5	0.7	0.1	0.5
Allergy or Eczema	0.1	0.2	0.4	-0.2	0.5	-0.7
Lung FVC	0.1	0.4	0.9	0.9	-0.7	-0.1
Hand grip strength (left)	0.1	0.2	0.5	-0.3	0.2	0.7
Average weekly spirits intake	0.1	0.1	0.2	0.1	0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	0.4	-0.3	-0.5
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.2	-0.5	-0.8
Hand grip strength (right)	0.1	0.2	0.4	0.0	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.0	0.4	-0.7
Waist circumference	0.1	0.5	1.3	1.1	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.8	0.0	0.1
Qualifications: None of the above	0.1	0.2	0.3	-0.3	-0.6	0.4
Medication: Simvastatin	0.1	0.1	0.1	-0.3	-0.2	0.3
Worrier / anxious feelings	0.1	0.2	0.3	0.5	-0.5	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.3	-0.7	0.2
Falls in the last year	0.1	0.2	0.4	0.7	-0.3	0.0
Medication: Lansoprazole	0.1	0.1	0.2	-0.3	-0.5	0.3
Qualifications: College or University degree	0.1	0.4	0.8	-0.4	0.9	0.4
Had major operations	0.1	0.1	0.4	0.1	0.6	-0.1
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	-0.6	-0.3
Hypertension (Self-reported)	0.1	0.3	0.7	-0.3	-0.8	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.6	-0.0	-0.1
Back pain experienced in last month	0.1	0.1	0.2	-0.5	0.2	0.2
Mother’s age at death	0.1	0.1	0.1	-0.3	0.3	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.0	-0.4	0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.4	0.3	0.2
Irritability	0.1	0.1	0.1	-0.3	-0.4	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.2	0.8	-0.0
Cardiovascular Disease	0.0	0.1	0.4	0.1	-0.6	-0.1
Hair Pigment	0.0	1.2	2.7	0.9	-1.6	0.2
Relative age voice broke	0.0	0.1	0.1	0.1	-0.2	0.4
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.2	-0.1	0.0
Medication: Ramipril	0.0	0.1	0.1	-0.4	-0.2	-0.1
Father’s age at death	0.0	0.0	0.1	-0.2	0.2	-0.0
Ever highly irritable/argumentative for 2 days	0.0	0.1	0.1	-0.2	0.3	-0.1

Hub : Genes

DGUOK

Models

Trait associations