Hub : Genes

C2orf81

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0191	0.0096	0.00370	0.015	0.007	0.004	0.007	0.006	0.0020	0.0260	0.0620	0.0250	0.0360
2	ROSMAP	Brain Pre-frontal Cortex	0.0336	0.0147	0.00075	0.013	0.018	0.015	0.017	0.017	0.0064	0.0019	0.0037	0.0026	0.0025
3	TCGA	Prostate Adenocarcinoma	0.0350	0.0278	0.00440	0.011	0.009	0.005	NA	0.014	0.0200	0.0380	0.0830	NA	0.0110
4	TCGA	Uterine Corpus Endometrial Carcinoma	0.1080	0.0810	0.00870	0.052	0.063	0.018	NA	0.044	0.0140	0.0078	0.1000	NA	0.0230

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.9	-0.1	-1.2	-1.4	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.1	2.8	-0.2	-0.9	-1.7	-0.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.5	-0.5	0.8	0.5	1.2
Depression (Nagel 2018)	0.0	0.1	0.2	-0.2	0.1	0.5	-0.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.7	-1.9	0.5	1.3	1.3
Neuroticism (Nagel 2018)	0.7	1.6	2.1	-1.0	1.4	1.1	1.4
Schizophrenia (2018)	0.2	0.3	1.1	-0.3	-0.1	-1.0	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	0.1	-0.6	-0.3
Worry (Nagel 2018)	0.1	0.2	0.5	-0.7	0.3	0.3	0.2
Alzheimer’s Disease (in mother)	2.4	2.8	3.4	-1.4	1.8	1.6	1.8
Alzheimer’s Disease (in father)	5.8	6.3	9.0	-3.0	2.0	2.8	2.1
Alzheimer’s Disease (including proxy)	5.2	7.6	8.3	-2.9	2.8	2.8	2.5
Crohns Disease (2017)	0.1	0.3	0.4	-0.5	0.5	0.3	0.7
Irritable Bowel Disease (IBD)	0.4	0.8	1.3	-1.1	0.5	0.9	0.9
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.7	0.1	0.6	0.4
Major Depression (MDD)	1.0	1.3	2.9	-1.7	1.0	0.6	0.9
Reaction Time	0.6	1.1	2.2	1.0	-0.4	-1.5	-1.0
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.1	-2.0	1.1	1.8	1.6
Breast Cancer	0.1	0.3	0.7	-0.9	0.2	-0.6	0.2
Ovarian Cancer	0.1	0.1	0.3	0.5	0.3	-0.3	-0.2
Prostate Cancer	0.0	0.1	0.2	0.4	-0.0	0.3	0.2
Age at First Birth	3.9	5.6	8.0	-2.8	2.3	1.6	2.6
Bipolar Disorder (2011)	2.6	2.5	3.1	1.3	-1.5	-1.8	-1.7
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.3
Coronary Artery Disease (CAD)	0.6	0.7	1.2	-0.7	0.7	1.1	0.7
Crohns Disease (2012)	0.5	0.9	1.3	1.1	-0.6	-1.0	-1.0
Mean Putamen Volume	0.2	0.2	0.6	-0.0	0.4	-0.8	-0.4
Fasting Glucose	0.4	0.5	1.1	-0.4	0.1	-1.1	-0.8
HbA1C	2.4	2.7	4.3	-2.1	2.0	1.2	1.1
HDL Cholesterol	0.0	0.1	0.2	0.4	0.2	0.3	0.1
LDL Cholesterol	1.3	2.1	2.6	1.0	-1.6	-1.6	-1.5
Lupus	0.5	0.7	1.0	0.3	-0.9	-1.0	-0.9
Neuroticism (2016)	0.0	0.0	0.1	0.1	-0.1	0.3	-0.2
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	-0.0	-0.2	0.0
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	0.7	0.6	0.1
Schizophrenia (2014)	0.4	0.9	1.3	0.3	-0.9	-1.1	-1.1
Triglycerides	0.3	0.5	1.0	0.4	-0.3	-1.0	-0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.2	0.3	-0.4	-0.4
Ulcerative Colitis	0.2	0.2	0.5	-0.0	-0.7	-0.5	-0.5
Blood Eosinophil Count	1.5	11.6	14.9	3.7	-2.4	-3.9	-3.4
Blood Platelet Count	4.5	52.5	62.6	5.8	-7.9	-7.5	-7.6
Blood Red Count	0.0	0.3	0.8	-0.3	-0.4	-0.9	-0.3
Blood White Count	0.1	0.5	1.1	1.0	-0.3	-0.4	-0.9
Heel T-Score	0.6	4.6	6.0	-2.5	2.0	1.8	2.2
BMI	0.2	1.2	2.2	0.4	-0.7	-1.4	-1.5
Height	1.4	26.7	36.4	6.0	-4.0	-5.2	-5.2
Waist Hip Ratio (WHR)	0.1	0.6	1.2	0.8	-0.8	-1.1	-0.4
Systolic Blood Pressure	0.5	2.6	3.5	-1.8	1.9	1.0	1.7
Smoking Status	0.4	0.9	3.2	1.8	-0.0	-0.2	-0.7
Allergy or Eczema	2.2	5.8	8.7	3.0	-2.0	-2.2	-2.3
Cardiovascular Disease	0.3	1.0	2.3	0.6	-0.5	-1.5	-1.1
Hypothyroidism (self reported)	0.2	0.5	1.4	1.2	-0.5	0.1	-0.5
Respiratory disease	1.3	2.9	4.7	2.2	-1.1	-1.9	-1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.2	1.1	-0.9	-0.4	-0.8
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.3	0.1	0.1	0.1
Lung FVC	1.3	6.5	8.2	-2.6	1.9	2.7	2.9
Neuroticism	0.5	1.3	1.7	-1.0	1.0	1.2	1.3
Chronotype (morning person)	0.7	1.6	2.8	0.3	-1.7	-1.4	-1.2
Hair Pigment	0.0	0.4	0.8	0.3	-0.9	-0.8	-0.0
Tanning	0.0	0.5	1.4	1.2	-0.7	0.1	-0.5
Hand grip strength (left)	0.0	0.0	0.0	0.0	0.2	-0.2	0.1
Number of treatments/medications taken	0.4	0.7	2.0	-0.4	1.4	-0.2	0.9
Average weekly spirits intake	1.0	1.3	1.7	1.3	-0.7	-1.2	-1.2
Sensitivity / hurt feelings	0.1	0.2	0.2	-0.4	0.5	0.3	0.5
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.3	0.1	0.6	0.1
Relative age of first facial hair	0.7	1.4	2.2	1.2	-0.8	-1.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	0.5	-0.5	0.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.7	0.2	0.9	0.6
Ever had hysterectomy (womb removed)	2.3	2.6	3.7	-1.9	1.9	1.1	1.4
Systolic blood pressure, automated reading	0.7	2.0	3.1	-1.8	1.3	0.9	1.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.2	-0.6	0.7	1.0	1.1
Angina	0.9	1.2	2.0	-0.8	0.7	1.4	1.3
Medication for hormone replacement therapy	1.0	1.1	1.7	-1.0	1.3	1.0	0.8
Vitamin and mineral supplements	0.0	0.1	0.1	-0.4	-0.2	-0.0	0.2
Supplements: Zinc	2.9	3.1	4.5	-2.1	1.1	1.9	1.7
Medication: Co-codamol	3.7	4.3	5.5	2.4	-2.1	-1.7	-2.1
Medication: Metformin	0.1	0.1	0.2	0.3	-0.3	0.4	-0.0
Diabetes (father)	2.2	2.7	3.4	-1.6	1.5	1.6	1.8
Diabetes (mother)	0.1	0.1	0.4	-0.6	-0.1	-0.1	0.4
Severe depression (siblings)	1.2	1.4	3.7	1.0	-1.9	-0.3	-0.9
Pack years adult smoking proportion	0.3	0.5	0.7	-0.4	0.7	0.8	0.8
Impedance of leg (right)	0.6	2.9	5.6	-1.1	1.3	1.8	2.4
Leg fat-free mass (left)	2.3	12.2	16.3	3.0	-3.1	-3.8	-4.0
Trunk fat percentage	0.3	1.1	2.0	-1.4	1.2	0.5	0.8
Hand grip strength (right)	0.0	0.1	0.1	0.1	0.2	-0.3	-0.2
Townsend deprivation index at recruitment	1.1	1.5	1.7	1.3	-1.1	-1.2	-1.3
Current tobacco smoking	0.1	0.2	0.7	0.8	-0.0	0.0	-0.4
Average weekly fortified wine intake	1.7	2.0	2.2	-1.3	1.4	1.5	1.4
Maternal smoking around birth	0.2	0.3	0.8	0.9	-0.5	0.2	-0.1
Fed-up feelings	0.4	0.8	1.8	-0.7	0.8	0.5	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.0	-0.6	0.5	-0.1
Relative age voice broke	0.1	0.2	0.4	-0.5	-0.2	0.4	0.6
Taking other prescription medications	0.2	0.3	1.1	0.3	1.1	-0.3	0.3
Age when periods started (menarche)	0.2	0.4	0.8	0.7	0.6	-0.9	0.1
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.4	-1.1	1.2	0.4	1.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.0	-1.1	1.4	1.0	0.9
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.3	0.5	0.5	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.1	0.5	0.2	0.3
High blood pressure	0.0	0.1	0.2	-0.3	0.4	-0.1	0.4
Hayfever, allergic rhinitis or eczema	4.5	9.7	14.4	3.8	-2.8	-2.7	-3.0
Multivitamins +/- minerals	0.2	0.2	0.5	0.7	-0.3	-0.0	-0.4
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.9	0.2	-0.2	-0.1
Supplements: Glucosamine	0.0	0.1	0.1	-0.4	0.1	0.3	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.3	0.1	-0.5	-0.0
Medication: Atenolol	4.7	5.9	8.2	-2.4	2.2	2.9	2.3
Medication: Levothyroxine sodium	3.2	5.4	7.1	2.3	-1.6	-2.6	-2.7
Sitting height	0.8	5.7	6.4	2.4	-2.3	-2.4	-2.5
Chronic bronchitis/emphysema (father)	1.1	1.3	3.0	1.7	-1.0	-0.4	-1.1
High blood pressure (mother)	0.0	0.1	0.1	-0.2	0.3	-0.4	0.2
Body mass index (BMI)	0.1	0.4	0.7	-0.4	-0.1	-0.8	-0.9
Impedance of leg (left)	0.6	2.8	5.2	-1.2	1.4	1.5	2.3
Leg predicted mass (left)	2.3	12.4	16.5	3.0	-3.1	-3.8	-4.1
Trunk fat mass	0.0	0.2	0.3	-0.5	0.3	-0.6	-0.3
Waist circumference	0.3	1.2	2.2	0.3	-0.9	-1.5	-1.4
Number of incorrect matches in round	0.1	0.1	0.4	0.1	0.2	0.7	0.2
Past tobacco smoking	0.1	0.2	0.6	-0.8	-0.1	0.3	0.4
Alcohol usually taken with meals	1.1	1.8	2.2	-1.2	1.4	1.1	1.5
Nervous feelings	0.1	0.2	0.4	-0.3	-0.1	0.6	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.4	1.2	-0.6	-0.4	-1.0
Hearing difficulty/problems with background noise	0.2	0.4	0.7	-0.1	0.7	0.8	0.6
Hair/balding pattern: Pattern 2	3.6	4.6	5.9	-1.7	2.4	2.3	2.0
Had menopause	0.3	0.3	0.7	-0.8	-0.7	-0.4	-0.1
Had other major operations	0.7	0.9	1.7	0.9	-0.6	-0.8	-1.3
Forced vital capacity (FVC)	0.0	0.1	0.1	0.1	0.2	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.3	-0.8	1.0	0.6	1.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.3	-1.8	0.5	0.4	1.1
Qualifications: None of the above	0.0	0.1	0.2	0.1	0.4	-0.2	0.5
Financial difficulties in last 2 years	1.8	2.4	3.6	1.3	-1.4	-1.9	-1.6
Mouth/teeth dental problems	0.7	1.1	2.9	-1.7	0.8	0.0	0.8
Heart attack	0.1	0.1	0.1	0.0	-0.4	-0.2	-0.3
Allergy	4.7	10.7	15.2	-3.9	3.0	3.1	3.1
Pain all over the body in last month	0.1	0.2	0.4	0.2	-0.3	-0.3	-0.6
Diabetes (self-reported)	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.2	1.1	-0.4	-1.5	-0.7
Medication: Ramipril	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Medication: Simvastatin	0.4	0.6	1.8	0.4	-0.2	-1.3	-0.7
Fluid intelligence score	0.6	1.3	2.4	-1.6	0.7	1.1	1.1
Illnesses of siblings	1.2	1.6	3.0	0.7	-1.1	-1.3	-1.7
Neuroticism score	0.1	0.2	0.3	-0.3	0.4	0.4	0.6
Weight	0.9	4.3	7.0	1.2	-1.5	-2.6	-2.5
Impedance of arm (right)	0.3	1.4	2.5	-0.8	1.2	1.1	1.6
Arm fat percentage (right)	0.3	1.4	2.7	-1.6	1.4	0.5	0.8
Trunk fat-free mass	2.6	15.1	19.7	3.4	-3.3	-4.4	-4.3
Hip circumference	0.4	1.8	3.2	0.3	-1.0	-1.8	-1.8
Time employed in main current job	1.2	1.4	3.1	-1.8	0.9	0.7	1.1
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.1	-0.1	-0.4	-0.1
Father’s age at death	0.6	0.8	2.1	-0.3	0.4	1.5	0.9
Worrier / anxious feelings	0.2	0.4	0.9	0.1	-0.6	-0.9	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.5	0.6	0.8	0.4
Falls in the last year	4.9	6.7	8.6	2.7	-2.0	-2.6	-2.9
Hair/balding pattern: Pattern 3	0.4	0.7	2.2	-0.2	-0.0	1.5	0.6
Number of live births	0.5	0.8	1.3	1.0	-1.1	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.4	0.0	0.3	-0.1	0.6
Pulse rate	2.1	3.5	4.5	1.9	-1.3	-2.0	-2.1
Happiness	0.2	0.3	0.6	0.5	-0.8	-0.5	-0.4
Noisy workplace	0.1	0.1	0.4	0.3	-0.1	-0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.8	-0.7	0.8	0.7	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.3	-1.1	1.0	0.7	0.9
Mouth/teeth dental problems: Dentures	1.9	3.2	4.0	-1.2	2.0	2.0	1.9
Asthma	0.6	1.3	3.3	1.8	-0.3	-1.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	0.6	0.3	-0.8	-0.6
Medication: Cholesterol lowering	0.4	0.6	1.5	-0.6	1.2	0.1	0.7
Depression (self-reported)	0.7	0.8	1.6	0.8	-1.3	-0.4	-0.8
Medication: Lansoprazole	2.5	2.8	5.0	-1.3	2.2	1.5	1.5
Prospective memory result	0.5	0.6	1.1	0.8	1.1	0.7	0.2
Lung cancer (father)	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.1
Illnesses of mother	0.5	0.6	1.2	1.1	-0.2	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.1	0.2	0.1	0.8
Pulse wave Arterial Stiffness index	2.4	2.8	6.1	2.5	-1.1	-1.2	-1.6
Impedance of arm (left)	0.6	2.6	4.1	-1.1	1.5	1.7	2.0
Arm fat mass (right)	0.1	0.3	0.6	-0.4	0.2	-0.8	-0.6
Trunk predicted mass	2.5	14.4	18.8	3.3	-3.2	-4.3	-4.2
Standing height	1.5	14.6	18.4	3.8	-3.3	-4.3	-3.9
Length of working week for main job	0.8	0.9	1.5	-0.5	0.9	1.0	1.2
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.8	-0.0	0.1	-0.4
Breastfed as a baby	1.0	1.2	1.6	-1.3	1.1	0.7	1.2
Tense / ‘highly strung’	0.2	0.3	0.8	-0.1	0.4	0.9	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.2	-0.1	-1.1	-0.8	-0.9
Hair/balding pattern: Pattern 4	1.7	4.1	9.0	0.9	-1.5	-3.0	-2.1
Birth weight of first child	1.2	2.2	3.2	1.8	-1.1	-1.6	-1.3
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.8	-0.2	-0.5	-0.3
Pulse wave reflection index	0.1	0.1	0.4	0.2	0.1	0.6	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	0.1	-0.1	0.3
Loud music exposure frequency	0.0	0.1	0.1	0.1	-0.2	-0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.5	0.4	0.1	-0.3
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.8	1.9	-1.0	-1.0	-1.4
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.4	0.0	-1.2	-0.2
Medication: Paracetamol	1.2	2.0	2.6	1.5	-1.1	-1.6	-1.3
Headache pain in last month	0.2	0.4	0.7	-0.3	0.6	0.8	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.6	1.0	-1.3	-0.7	-0.9
Glaucoma (self-reported)	0.9	1.1	1.3	-1.1	1.2	0.7	1.1
Gout (self-reported)	0.8	1.1	2.7	0.6	-0.5	-1.6	-1.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.4	1.9	-1.0	-1.0	-1.3
Medication: Amlodipine	0.2	0.3	0.8	-0.5	0.9	0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.5	0.4	-0.3	0.3
Birth weight	0.0	0.1	0.3	-0.0	0.2	-0.5	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	-0.3	0.8	1.0	1.0
High blood pressure (siblings)	4.1	5.9	7.8	-1.8	2.7	2.3	2.8
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.3	0.0	-0.2	0.3
Body fat percentage	0.3	1.3	2.5	-1.6	1.2	0.6	0.9
Leg fat percentage (right)	0.4	1.6	3.0	-1.7	1.1	0.9	1.1
Arm fat-free mass (right)	1.7	8.5	12.4	2.3	-2.5	-3.5	-3.3
Exposure to tobacco smoke outside home	0.2	0.2	0.6	0.8	0.2	-0.3	-0.3
Comparative body size at age 10	0.1	0.2	0.5	0.4	-0.4	-0.3	-0.7
Number of full brothers	1.5	1.9	2.8	1.7	-1.2	-1.1	-1.4
Worry too long after embarrassment	0.2	0.3	0.6	-0.4	0.4	0.3	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.6	-0.9	0.6	1.6	1.0
Wheeze or whistling in the chest in last year	0.6	1.1	3.0	1.7	-0.4	-0.3	-1.0
Number of children fathered	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.2	-1.4	1.5	1.0	1.2
Age at first live birth	1.2	2.2	3.2	-1.8	1.7	0.8	1.4
Pulse wave peak to peak time	2.2	2.6	5.8	-2.4	1.1	1.2	1.5
Health satisfaction	1.1	1.4	2.4	1.6	-0.9	-0.8	-1.2
Shortness of breath walking on level ground	1.3	1.5	2.6	1.1	-1.6	-0.9	-1.2
Qualifications: College or University degree	0.0	0.1	0.1	-0.3	-0.3	0.2	0.2
Eye problems/disorders: None of the above	0.4	0.4	1.1	1.0	-0.7	0.0	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	1.1	-0.2	0.2	-0.4
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.2	-0.1	-0.3	0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	2.4	0.2	-1.5	0.1	-0.7
Neck or shoulder pain in last month	0.3	0.4	0.6	0.6	-0.5	-0.7	-0.8
Medication: Blood pressure	0.5	0.9	1.2	-0.9	1.1	0.8	1.0
Angina (self-reported)	0.9	1.1	1.9	-0.6	0.7	1.4	1.3
Migraine (self-reported)	0.1	0.1	0.2	-0.4	0.5	0.1	0.2
Medication: Ibuprofen	0.3	0.4	0.5	0.7	0.4	-0.7	-0.7
Medication: Allopurinol	0.3	0.4	0.9	0.3	0.1	-0.9	-0.7
Medication: Omeprazole	4.3	5.2	7.1	-1.8	2.1	2.7	2.4
Medication: Seretide 50 evohaler	2.2	2.5	4.0	2.0	-1.4	-1.5	-1.4
Mean time to correctly identify matches	1.0	1.8	3.3	1.2	-0.8	-1.8	-1.4
Heart disease (mother)	0.8	0.9	1.7	-1.1	0.4	0.8	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	5.8	1.7	-2.0	-2.4	-2.1
Whole body fat mass	0.1	0.2	0.4	-0.6	0.2	-0.7	-0.4
Leg fat mass (right)	0.0	0.2	0.4	-0.3	-0.1	-0.6	-0.5
Arm predicted mass (right)	1.7	8.6	11.4	2.4	-2.6	-3.4	-3.3
Pulse rate, automated reading	0.6	2.0	2.4	1.6	-1.3	-1.3	-1.4
Alcohol intake frequency.	0.1	0.3	0.8	-0.6	-0.9	0.0	-0.1
Comparative height size at age 10	1.7	9.4	11.3	2.7	-2.9	-3.4	-3.3
Number of full sisters	0.2	0.3	1.0	1.0	0.3	-0.3	-0.2
Suffer from ‘nerves’	1.2	1.9	2.2	-1.3	1.3	1.5	1.5
Overall health rating	0.1	0.1	0.3	-0.0	-0.3	-0.4	-0.5
Chest pain or discomfort	0.6	0.8	1.7	0.1	0.8	1.3	0.9
Had major operations	1.2	1.5	2.2	1.5	-0.9	-1.1	-1.3
Age at last live birth	1.2	1.7	2.1	-1.2	1.4	1.0	1.4
Family relationship satisfaction	1.6	2.0	2.3	-1.4	1.5	1.3	1.5
Leg pain on walking	5.1	6.4	10.6	2.1	-1.5	-3.3	-2.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	0.8	-0.4	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.3	0.6	-0.2	0.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.0	-1.1	0.8	1.4	1.0
Medication: Aspirin	0.6	0.8	2.4	-0.7	1.6	-0.2	0.6
Supplements: Vitamin C	1.5	1.7	2.9	-0.4	1.7	1.6	1.2
Knee pain experienced in last month	1.1	1.8	2.9	1.7	-0.6	-1.6	-1.1
Hypertension (Self-reported)	0.1	0.2	0.5	-0.4	0.7	0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.4	-1.2	1.2	0.8	1.0
Illnesses of father: Heart disease	1.4	2.0	3.0	-1.7	1.3	0.7	1.7
Illnesses of siblings: Diabetes	2.3	2.8	5.9	2.4	-0.4	-2.0	-1.2
Smoking status: Previous	0.2	0.3	0.6	0.7	-0.2	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.3	8.4	2.9	-2.3	-2.8	-2.9
Whole body fat-free mass	2.6	14.9	18.8	3.3	-3.3	-4.3	-4.3
Leg fat-free mass (right)	2.6	14.1	18.7	3.2	-3.2	-4.2	-4.3
Arm fat percentage (left)	0.5	1.8	3.4	-1.9	1.5	0.8	1.0
Average weekly red wine intake	0.7	1.1	1.5	-0.5	1.2	1.2	1.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.7	-0.4	-0.4	-0.5
Mood swings	0.5	1.0	1.7	-1.1	1.3	-0.5	0.9
Loneliness, isolation	0.1	0.1	0.4	0.3	-0.6	-0.2	-0.2
Long-standing illness, disability or infirmity	0.6	1.0	1.5	-1.2	0.7	1.1	0.8
Ever had bowel cancer screening	0.2	0.3	0.6	0.3	-0.3	-0.5	-0.8
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.0	0.1	0.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.9	0.4	1.0	0.0	-0.0
Friendships satisfaction	0.2	0.2	0.5	0.7	-0.4	0.0	-0.4
Qualifications: nursing, teaching	1.0	1.6	2.0	-1.4	0.9	1.3	1.4
Commuting to job workplace: Walk	1.1	1.1	2.1	1.4	-1.0	-0.5	-1.1
Eye problems/disorders: Cataract	0.2	0.2	0.8	-0.9	-0.2	0.0	0.4
Mouth/teeth dental problems: Mouth ulcers	5.3	8.5	9.7	2.6	-2.8	-3.1	-3.1
Medication for cholesterol	0.7	1.1	2.1	1.3	-1.4	-0.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.8	0.2	-0.3	-0.1
Back pain experienced in last month	0.4	0.6	1.3	0.8	-0.3	-0.6	-1.1
Mineral and other dietary supplements	0.7	1.0	1.6	-0.5	1.2	0.7	1.2
Breast cancer (self-reported)	0.2	0.2	0.4	-0.1	0.7	-0.6	-0.1
Asthma (self-reported)	0.7	1.4	3.7	1.9	-0.3	-1.2	-0.7
Osteoporosis (self-reported)	2.2	2.8	3.3	-1.6	1.6	1.6	1.8
Osteoarthritis (self-reported)	0.6	0.7	1.4	0.9	-0.5	-0.8	-1.2
Medication: Aspirin	1.2	1.5	3.7	-1.1	1.9	0.2	1.1
Medication: Gliclazide	0.1	0.1	0.5	0.1	0.1	-0.7	-0.0
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.4	0.1	-0.7	-0.6
Smoking status: Current	0.1	0.2	0.7	0.8	0.1	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.3	-1.8	1.2	1.6	2.1
Whole body water mass	2.5	14.1	17.9	3.3	-3.2	-4.2	-4.2
Leg predicted mass (right)	2.6	14.0	18.6	3.2	-3.2	-4.1	-4.3
Arm fat mass (left)	0.1	0.2	0.4	-0.7	0.4	-0.5	-0.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.2	0.9	-0.7	-1.1	-0.7
Average weekly champagne plus white wine intake	1.5	2.1	3.6	-1.4	1.9	1.0	1.4
Miserableness	0.1	0.2	0.7	0.8	-0.3	-0.4	-0.1
Guilty feelings	0.5	0.8	1.2	1.1	1.1	0.8	0.3
Wears glasses or contact lenses	2.1	2.4	3.7	0.4	-1.9	-1.9	-1.5
Ever taken oral contraceptive pill	1.0	1.1	2.9	1.7	-0.8	-0.4	-0.9
Hearing aid user	0.5	0.5	1.0	0.9	-0.3	-0.4	-1.0
Mother’s age at death	0.2	0.3	0.5	-0.7	-0.7	-0.3	-0.4
Financial situation satisfaction	0.3	0.4	1.1	1.1	-0.4	-0.1	-0.6
Tinnitus: Yes, now most or all of the time	1.9	2.2	2.8	-1.1	1.5	1.7	1.6
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.5	0.7	0.2	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.4	1.0	0.6	0.6
Medication: Blood pressure	1.7	3.3	4.4	-2.0	2.1	1.3	1.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.9	-0.0	-0.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.6	0.6	-1.1	-1.1	-1.3
High cholesterol (Self-reported)	0.1	0.1	0.1	0.4	0.4	-0.2	-0.3
Medication: Bendroflumethiazide	0.4	0.6	1.9	-0.3	1.4	-0.5	-0.3
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.0	-0.4	0.1
Medication: Lisinopril	2.6	3.4	5.2	-2.0	2.3	1.3	1.6
Medication: Atorvastatin	0.2	0.3	0.8	-0.0	0.9	0.4	0.4
Illnesses of father: High blood pressure	1.0	1.3	2.2	-0.7	0.8	1.5	1.3
Alcohol drinker status: Never	0.1	0.1	0.3	-0.0	-0.5	-0.0	-0.0
Ever smoked	0.2	0.3	0.6	0.1	0.8	0.5	0.5
Basal metabolic rate	2.2	12.3	16.1	2.9	-3.0	-4.0	-4.0
Leg fat percentage (left)	0.3	1.1	2.6	-1.6	1.0	0.5	0.8
Arm fat-free mass (left)	2.2	11.0	14.9	2.8	-2.8	-3.9	-3.7
Number of operations (self-reported)	1.1	1.7	2.3	1.1	-1.3	-1.2	-1.5
Average weekly beer plus cider intake	0.0	0.1	0.1	0.3	-0.4	0.0	-0.1
Irritability	4.0	6.7	7.6	-2.3	2.7	2.6	2.8
Risk taking	0.2	0.2	0.6	0.8	0.4	0.2	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.5	-0.1	-0.2	-0.7	-0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.1	0.4	-0.5	0.2
Age started oral contraceptive pill	0.3	0.3	0.8	-0.5	0.5	0.4	0.9
Diastolic blood pressure, automated reading	0.4	1.2	2.1	-1.4	1.0	0.4	1.2
Ever depressed for a whole week	0.2	0.3	1.0	-1.0	0.0	-0.4	0.1
Unable to work because of sickness or disability	1.7	2.2	2.8	1.7	-1.4	-1.3	-1.4
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.3	0.7	0.6	0.5
Myopia	0.2	0.4	0.5	-0.7	0.7	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	0.2	-0.3	0.3	-0.1
Cholesterol lowering medication	1.0	1.5	1.9	1.2	-1.0	-1.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	3.7	4.5	5.6	-1.8	2.0	2.4	2.3
Pain experienced in last month	2.4	4.0	7.0	-2.6	1.1	1.7	2.2
Supplements: Calcium	0.3	0.4	1.1	-0.4	0.1	1.1	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	-0.3	0.2	0.7	0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	0.2	-0.4	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	-0.3	-0.0	-1.2	-0.1
Heart disease (siblings)	0.3	0.4	0.5	-0.6	-0.3	0.7	0.7
Alcohol drinker status: Previous	0.0	0.0	0.1	0.3	0.2	0.1	0.1
Pack years of smoking	0.9	1.3	1.5	-1.0	1.1	1.2	1.2
Impedance of whole body	0.6	3.2	5.4	-1.2	1.6	1.9	2.3
Leg fat mass (left)	0.1	0.4	0.9	-0.1	-0.3	-0.9	-0.8
Arm predicted mass (left)	2.0	10.4	14.1	2.6	-2.7	-3.8	-3.6