TWAS hub - CLCN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.151	0.0600	6.7e-03	-0.006	NA	0.020	NA	-0.006	8.7e-01	NA	0.04300	NA	0.82000
2	TCGA	Brain Lower Grade Glioma	0.061	0.0238	8.3e-05	0.034	0.036	0.029	NA	0.031	8.5e-05	5e-05	0.00028	NA	0.00016

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ever smoked	11.7	20.5	24.9	4.0	5.0
Smoking Status	8.0	19.1	19.4	4.3	4.4
Past tobacco smoking	7.1	13.0	13.8	-3.5	-3.7
Primary Biliary Cirrhosis	6.9	9.9	14.0	2.4	3.7
Blood Platelet Count	6.7	77.4	116.6	10.8	6.2
Reaction Time	5.9	11.2	16.8	-4.1	-2.4
Medication: Aspirin	5.3	6.9	8.5	2.9	2.3
Age when periods started (menarche)	5.2	12.5	14.4	3.3	3.8
Hair/balding pattern: Pattern 3	4.8	7.1	12.7	-1.2	-3.6
Smoking status: Previous	4.6	6.8	8.2	2.9	2.3
Guilty feelings	4.4	6.5	7.2	2.7	2.4
Medication for pain relief, constipation, heartburn	4.2	7.2	8.2	-2.9	-2.5
Supplements: Glucosamine	4.0	5.3	7.8	2.8	1.7
Chronotype (morning person)	3.8	8.7	11.5	-2.5	-3.4
Medication: Aspirin	3.8	4.9	5.2	2.3	2.2
Ever taken oral contraceptive pill	3.8	4.2	4.8	2.2	1.9
Bipolar Disorder (2018)	3.7	5.9	6.0	2.4	2.4
Qualifications: O levels/GCSEs or equivalent	3.7	5.9	9.4	1.6	3.1
Number of self-reported non-cancer illnesses	3.7	6.5	8.1	2.8	2.2
Miserableness	3.7	6.4	8.1	2.8	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.4	5.2	5.9	2.1	2.4
Cardiovascular Disease	3.2	10.6	11.8	3.1	3.4
Hand grip strength (right)	3.2	8.8	9.3	3.0	2.9
Mean time to correctly identify matches	3.2	6.0	9.0	-3.0	-1.8
Medication: Metformin	3.1	4.4	5.1	-1.9	-2.2
Medication: Paracetamol	3.1	5.1	6.8	2.6	1.9
Bilateral oophorectomy (both ovaries removed)	3.0	3.4	4.2	-1.6	-2.1
Schizophrenia vs Biploar Disorder	2.9	3.8	7.6	-2.8	0.0
Verbal and Numeric Reasoning (VNR)	2.8	6.8	11.7	1.4	3.4
Crohns Disease (2012)	2.7	4.4	8.8	3.0	0.0
Prospective memory result	2.6	3.1	5.9	-0.6	-2.4
Qualifications: nursing, teaching	2.4	3.7	3.9	2.0	1.9
Alcohol drinker status: Never	2.4	2.9	4.7	-1.0	-2.2
Leg fat percentage (right)	2.3	8.4	10.2	-2.6	-3.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	3.4	1.6	1.8
Knee pain experienced in last month	2.3	3.6	5.5	1.3	2.3
Trunk fat percentage	2.2	8.7	8.9	-3.0	-2.9
Body fat percentage	2.2	8.8	9.0	-2.9	-3.0
Hypertension (Self-reported)	2.2	6.0	7.7	2.1	2.8
Leg fat percentage (left)	2.2	7.9	8.4	-2.7	-2.9
Glaucoma (self-reported)	2.1	2.5	3.4	1.2	1.9
Back pain experienced in last month	2.1	3.0	4.0	1.4	2.0
Medication for hormone replacement therapy	1.8	2.0	2.2	-1.4	-1.5
Noisy workplace	1.8	2.2	3.1	1.1	1.8
Medication: Cholesterol lowering	1.8	2.8	4.5	2.1	1.0
Pulse wave reflection index	1.8	2.2	2.3	1.5	1.5
Ulcerative Colitis	1.7	2.5	4.0	2.0	1.0
Hand grip strength (left)	1.7	4.5	4.9	2.0	2.2
Qualifications: College or University degree	1.7	5.2	5.7	2.4	2.2
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	3.9	-2.0	-1.2
Neuroticism (2016)	1.6	2.3	4.5	-2.1	-0.2
Falls in the last year	1.6	2.2	3.4	-1.0	-1.9
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	4.1	-1.5	-2.0
Major Depression (MDD)	1.5	1.8	3.5	1.9	0.0
Alcohol usually taken with meals	1.5	2.5	2.7	-1.5	-1.7
Medication: Simvastatin	1.5	2.2	3.1	1.8	1.1
Intelligence (Savage-Jansen 2018)	1.4	4.3	8.3	0.6	2.9
Ever had hysterectomy (womb removed)	1.4	1.6	1.9	-1.1	-1.4
Diabetes (mother)	1.4	1.8	2.2	-1.5	-1.2
Impedance of leg (right)	1.4	6.7	11.4	-1.4	-3.4
High blood pressure	1.4	3.8	5.7	1.4	2.4
Arm fat percentage (right)	1.4	5.7	6.4	-2.5	-2.2
Medication: Paracetamol	1.4	2.2	3.0	1.7	1.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	2.9	-1.7	-1.2
Medication: Ventolin 100micrograms inhaler	1.3	1.6	3.2	-0.2	-1.8
Arm fat percentage (left)	1.3	5.2	5.9	-2.4	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	2.5	0.4	1.6
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.3	0.2	1.8
Impedance of whole body	1.3	6.8	10.6	-1.7	-3.3
Bipolar Disorder or Schizophrenia	1.2	3.0	4.5	2.1	1.2
Current tobacco smoking	1.2	2.0	3.2	0.9	1.8
Medication: Lansoprazole	1.2	1.4	2.7	0.4	1.6
Lung cancer (father)	1.2	1.4	1.8	1.3	-1.0
Birth weight	1.2	2.7	3.6	-1.3	-1.9
Wheeze or whistling in the chest in last year	1.2	2.1	2.2	1.4	1.5
Alcohol intake frequency.	1.2	2.8	3.1	-1.8	-1.6
Vascular/heart problems diagnosed by doctor	1.2	3.2	4.8	-1.3	-2.2
Ovarian Cancer	1.1	1.4	2.7	0.2	-1.7
Hypothyroidism (self reported)	1.1	2.5	4.4	-0.8	-2.1
Average weekly spirits intake	1.1	1.3	2.4	-1.6	-0.5
Impedance of leg (left)	1.1	5.2	8.4	-1.4	-2.9
Trunk fat mass	1.1	4.6	4.6	-2.1	-2.1
Qualifications: None of the above	1.1	2.4	3.1	-1.3	-1.8
Fluid intelligence score	1.1	2.3	4.6	-0.2	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	3.1	0.8	1.8
Worry too long after embarrassment	1.1	1.9	2.3	1.2	1.5
Medication: Blood pressure	1.1	1.9	2.7	1.1	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.4	1.1	1.8
Eye problems/disorders: Glaucoma	1.1	1.3	1.4	1.1	1.2
Depressed Affect (Nagel 2018)	1.0	2.2	2.8	1.2	1.7
Rheumatoid Arthritis	1.0	1.4	2.4	1.6	0.6
Blood Eosinophil Count	1.0	7.5	8.7	2.9	2.5
Medication: Levothyroxine sodium	1.0	1.7	1.9	-1.2	-1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	1.2	-1.1	-1.1
Had other major operations	1.0	1.2	1.7	-1.3	-0.9
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.1	1.4	0.5
Medication: Ramipril	1.0	1.3	2.4	-0.3	1.6
Impedance of arm (right)	1.0	4.4	6.9	-1.4	-2.6
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.2	0.6	2.0
Impedance of arm (left)	1.0	4.6	7.2	-1.4	-2.7
Whole body fat mass	1.0	4.3	4.5	-2.1	-2.0
Leg fat mass (right)	1.0	3.9	4.5	-1.8	-2.1
Number of full sisters	1.0	1.2	2.2	1.5	0.4
Medication: Gliclazide	1.0	1.2	1.5	-0.9	-1.2
Smoking status: Current	1.0	1.6	2.9	0.6	1.7
Heart disease (siblings)	1.0	1.2	1.7	1.3	0.9
HbA1C	0.9	1.0	1.1	0.9	1.0
Blood Red Count	0.9	8.5	11.0	-3.3	-2.5
Townsend deprivation index at recruitment	0.9	1.3	1.8	0.9	1.3
Multivitamins +/- minerals	0.9	1.2	2.3	1.5	0.3
Alcohol intake versus 10 years previously	0.9	1.3	2.4	-0.4	-1.6
Loud music exposure frequency	0.9	0.9	1.8	0.3	1.3
Number of full brothers	0.9	1.2	2.3	1.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.2	1.0	1.1
Ever had bowel cancer screening	0.9	1.0	1.2	1.1	-0.9
Financial situation satisfaction	0.9	1.1	1.2	1.1	1.0
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	0.0	-1.5
Leg fat mass (left)	0.9	3.5	3.5	-1.9	-1.9
Alzheimer’s Disease (in mother)	0.8	0.9	1.1	-0.8	-1.0
Schizophrenia (2014)	0.8	1.8	2.9	1.7	0.8
Relative age voice broke	0.8	1.3	1.6	1.3	1.0
Medication: Atenolol	0.8	1.0	1.6	0.6	1.3
Time employed in main current job	0.8	0.9	1.7	-0.0	1.3
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-0.1	1.3
Medication: Ibuprofen	0.8	0.9	1.6	0.6	1.3
Eye problems/disorders: Cataract	0.8	0.9	1.1	1.0	0.8
Mineral and other dietary supplements	0.8	1.1	1.4	-0.9	-1.2
Hearing aid user	0.8	0.9	1.5	1.2	0.5
Irritable Bowel Disease (IBD)	0.7	1.6	2.6	1.6	0.7
Breast Cancer	0.7	1.8	3.4	-1.8	-0.4
Waist Hip Ratio (WHR)	0.7	3.1	3.3	1.8	1.7
Trunk fat-free mass	0.7	3.8	4.9	1.6	2.2
Illnesses of mother	0.7	0.8	1.7	1.3	-0.0
Arm fat mass (right)	0.7	2.9	3.6	-1.9	-1.4
Crohns Disease (2017)	0.6	1.3	2.3	1.5	0.6
Triglycerides	0.6	0.9	1.9	0.1	1.4
Serious illness, injury or assault to yourself	0.6	0.8	1.2	1.1	0.6
Forced vital capacity (FVC)	0.6	2.4	3.7	1.9	1.0
Mouth/teeth dental problems	0.6	0.9	1.6	1.3	-0.4
Hip circumference	0.6	2.6	3.5	-1.9	-1.3
Asthma	0.6	1.2	2.4	1.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.0	0.7	1.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.2	-0.0
Trunk predicted mass	0.6	3.5	4.4	1.6	2.1
Peak expiratory flow (PEF)	0.6	1.3	2.4	1.6	0.4
Pulse wave peak to peak time	0.6	0.7	1.3	-1.2	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-0.2	-1.1
Asthma (self-reported)	0.6	1.3	2.3	1.5	-0.5
Arm fat mass (left)	0.6	2.5	3.2	-1.8	-1.3
Mother’s age at death	0.6	0.8	1.6	1.3	-0.2
Commuting to job workplace: Public transport	0.6	0.7	1.0	-0.6	-1.0
Fractured/broken bones in last 5 years	0.6	0.8	0.9	-0.8	-1.0
Supplements: Calcium	0.6	0.7	1.3	0.3	1.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.0	-0.7	-1.0
Blood White Count	0.5	4.0	5.1	2.3	1.7
Relative age of first facial hair	0.5	1.1	1.9	0.5	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	1.0	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	0.2	-1.0
Pack years adult smoking proportion	0.5	0.8	1.5	-0.3	-1.2
Body mass index (BMI)	0.5	2.3	3.4	-1.8	-1.1
Nervous feelings	0.5	1.0	1.6	-1.3	-0.6
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	0.3	1.1
Financial difficulties in last 2 years	0.5	0.7	1.2	0.3	-1.1
Pain all over the body in last month	0.5	0.5	0.6	0.8	-0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.7	0.1	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	0.1	1.1
Suffer from ‘nerves’	0.5	0.7	1.4	-1.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.7	-0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-1.1	0.0
Whole body fat-free mass	0.5	2.6	3.8	1.2	2.0
Osteoarthritis (self-reported)	0.5	0.6	0.9	0.9	0.6
Pack years of smoking	0.5	0.7	1.1	-0.5	-1.1
Worry (Nagel 2018)	0.4	0.7	1.1	-1.0	-0.6
Systolic Blood Pressure	0.4	2.1	3.6	0.8	1.9
Number of treatments/medications taken	0.4	0.7	0.9	0.8	0.9
Sensitivity / hurt feelings	0.4	0.7	1.3	-1.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	1.0	0.1
Taking other prescription medications	0.4	0.6	0.6	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.5	-1.2	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.7	-0.0	-1.3
Stomach or abdominal pain in last month	0.4	0.5	0.5	0.7	0.7
Number of incorrect matches in round	0.4	0.6	1.1	-0.2	-1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-1.1	-0.3
Allergy	0.4	1.0	1.6	-0.6	1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.8	1.7	0.4
Depression (self-reported)	0.4	0.5	0.9	0.4	0.9
Arm fat-free mass (right)	0.4	2.0	2.9	1.1	1.7
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	0.9	-0.1
Overall health rating	0.4	0.9	1.6	-0.5	1.2
Family relationship satisfaction	0.4	0.5	0.8	0.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	0.5	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	0.9	0.2
Leg fat-free mass (right)	0.4	2.2	3.8	0.8	1.9
Average weekly red wine intake	0.4	0.6	0.9	-1.0	-0.4
Breast cancer (self-reported)	0.4	0.5	0.9	-1.0	0.3
Whole body water mass	0.4	2.5	3.6	1.2	1.9
Leg predicted mass (right)	0.4	2.0	3.4	0.7	1.9
Wears glasses or contact lenses	0.4	0.5	0.9	-0.3	-0.9
Medication: Bendroflumethiazide	0.4	0.5	0.8	0.9	0.6
Risk taking	0.4	0.7	1.1	-0.5	-1.0
Myopia	0.4	0.6	1.2	-0.2	-1.1
Alcohol drinker status: Previous	0.4	0.4	0.6	0.8	0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.4	0.1	1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.6	-0.5
Coronary Artery Disease (CAD)	0.3	0.3	0.7	0.8	0.0
Height	0.3	6.6	7.6	2.8	2.4
Allergy or Eczema	0.3	0.8	1.1	0.6	-1.1
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.4	0.9
Illnesses of siblings	0.3	0.5	0.5	-0.6	-0.7
Neuroticism score	0.3	0.7	0.9	0.9	0.7
Father’s age at death	0.3	0.3	0.7	0.2	0.8
Number of live births	0.3	0.4	0.7	-0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	0.0	0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	1.1	1.0	1.1
Number of children fathered	0.3	0.4	0.7	-0.0	-0.8
Age at first live birth	0.3	0.6	0.6	0.7	0.8
Emphysema/chronic bronchitis	0.3	0.3	0.4	-0.4	-0.7
Migraine (self-reported)	0.3	0.3	0.4	0.7	-0.4
Medication: Allopurinol	0.3	0.5	0.8	0.3	0.9
Medication: Omeprazole	0.3	0.4	0.8	0.9	0.0
Arm predicted mass (right)	0.3	1.6	2.4	0.9	1.5
Comparative height size at age 10	0.3	1.6	2.2	-1.0	-1.5
Leg pain on walking	0.3	0.4	0.7	-0.0	0.8
Supplements: Vitamin C	0.3	0.4	0.4	-0.6	0.7
Long-standing illness, disability or infirmity	0.3	0.5	0.9	0.4	1.0
Diabetes diagnosed by doctor	0.3	0.5	0.9	-0.5	-0.9
Commuting to job workplace: Walk	0.3	0.4	0.5	0.7	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.4	0.8
Number of operations (self-reported)	0.3	0.4	0.7	-0.9	0.2
Cholesterol lowering medication	0.3	0.5	0.6	-0.8	0.6
Schizophrenia (2018)	0.2	0.3	0.5	0.7	-0.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.6	0.3
Fasting Glucose	0.2	0.2	0.4	-0.6	0.2
Heel T-Score	0.2	1.9	3.6	-1.9	-0.3
Respiratory disease	0.2	0.3	0.6	0.8	-0.3
Lung FVC	0.2	0.9	1.8	1.3	0.2
Tanning	0.2	2.6	3.4	-1.9	-1.3
Systolic blood pressure, automated reading	0.2	0.6	1.3	-0.1	1.1
Supplements: Zinc	0.2	0.2	0.3	0.5	0.5
Medication: Co-codamol	0.2	0.2	0.4	-0.6	-0.2
Leg fat-free mass (left)	0.2	1.3	2.2	0.7	1.5
Sitting height	0.2	1.1	1.6	1.3	0.7
Leg predicted mass (left)	0.2	1.0	1.8	0.5	1.3
Waist circumference	0.2	0.9	1.3	-1.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.3	0.6	-0.5
Had menopause	0.2	0.3	0.5	-0.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.3	0.5	-0.6
Happiness	0.2	0.2	0.4	-0.1	0.7
Standing height	0.2	2.3	3.6	1.9	1.0
Length of working week for main job	0.2	0.2	0.5	0.1	0.7
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.2	-0.6
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.4	0.6	0.7
Gout (self-reported)	0.2	0.3	0.5	-0.2	0.7
Medication: Amlodipine	0.2	0.2	0.3	-0.4	0.5
Health satisfaction	0.2	0.3	0.4	-0.4	-0.7
Friendships satisfaction	0.2	0.3	0.5	-0.7	-0.1
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.7	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	0.4	0.6
Medication: Blood pressure	0.2	0.4	0.5	0.6	0.7
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	0.1
Basal metabolic rate	0.2	1.0	1.7	0.6	1.3
Commuting to job workplace: Cycle	0.2	0.3	0.3	0.5	0.6
Depression (Nagel 2018)	0.1	0.2	0.3	0.2	0.5
Ulcerative Colitis (UC)	0.1	0.3	0.5	0.7	-0.1
Prostate Cancer	0.1	0.1	0.2	0.4	0.0
Age at First Birth	0.1	0.2	0.3	-0.3	0.6
Mean Putamen Volume	0.1	0.1	0.1	0.3	0.2
HDL Cholesterol	0.1	0.1	0.2	-0.2	-0.4
Lupus	0.1	0.1	0.2	-0.0	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.5	0.0
BMI	0.1	0.5	0.5	-0.7	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.4	-0.3	-0.6
Lung FEV1/FVC ratio	0.1	0.6	1.3	1.1	-0.1
Neuroticism	0.1	0.3	0.3	0.5	0.6
Hair Pigment	0.1	1.5	1.6	1.3	-1.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.6	-0.0
Angina	0.1	0.2	0.3	0.0	-0.6
Fed-up feelings	0.1	0.2	0.4	0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.2	0.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.2	-0.4
High blood pressure (mother)	0.1	0.2	0.2	-0.3	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.4	-0.5	0.6
Diabetes (self-reported)	0.1	0.2	0.4	-0.0	-0.6
Weight	0.1	0.7	0.9	-0.9	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.5	-0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.5	-0.1
Headache pain in last month	0.1	0.3	0.4	0.6	-0.4
High blood pressure (siblings)	0.1	0.2	0.3	0.2	0.5
Comparative body size at age 10	0.1	0.3	0.6	-0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.2	0.3	0.4
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.1	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.3	-0.4
Angina (self-reported)	0.1	0.1	0.2	0.2	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.4	-0.2
Heart disease (mother)	0.1	0.1	0.2	-0.1	0.4
Pulse rate, automated reading	0.1	0.3	0.5	0.7	-0.3
Chest pain or discomfort	0.1	0.2	0.4	-0.1	0.6
Had major operations	0.1	0.1	0.1	0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.3	0.3
Mood swings	0.1	0.1	0.1	0.2	0.4
Loneliness, isolation	0.1	0.1	0.2	-0.4	-0.2
Medication for cholesterol	0.1	0.2	0.3	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.7	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.2	0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.2	-0.4	-0.4
Medication: Lisinopril	0.1	0.2	0.3	0.5	-0.2
Medication: Atorvastatin	0.1	0.1	0.2	-0.4	-0.1
Arm fat-free mass (left)	0.1	0.6	1.1	0.4	1.1
Diastolic blood pressure, automated reading	0.1	0.5	0.6	-0.5	0.8
Ever depressed for a whole week	0.1	0.1	0.1	0.4	-0.1
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.5	0.2
Arm predicted mass (left)	0.1	0.7	1.3	0.4	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	-0.0
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	-0.1
Diabetes (father)	0.0	0.0	0.0	-0.2	-0.2
Severe depression (siblings)	0.0	0.0	0.1	0.0	0.3
Average weekly fortified wine intake	0.0	0.0	0.0	0.1	0.2
Maternal smoking around birth	0.0	0.0	0.1	0.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.1	0.2
Heart attack	0.0	0.0	0.1	-0.3	-0.1
Worrier / anxious feelings	0.0	0.0	0.0	0.2	0.1
Pulse rate	0.0	0.0	0.0	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.4	0.0
Breastfed as a baby	0.0	0.0	0.1	-0.1	0.3
Birth weight of first child	0.0	0.1	0.1	-0.3	0.1
Exposure to tobacco smoke outside home	0.0	0.1	0.1	-0.3	-0.2
Shortness of breath walking on level ground	0.0	0.0	0.0	-0.0	-0.1
Age at last live birth	0.0	0.1	0.1	0.0	0.4
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.0	0.1
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	0.3
Average weekly beer plus cider intake	0.0	0.1	0.1	0.2	0.3
Irritability	0.0	0.0	0.1	-0.3	-0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.1	0.2
Age started oral contraceptive pill	0.0	0.0	0.0	0.1	0.2
Pain experienced in last month	0.0	0.0	0.1	-0.0	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.0	0.1

Hub : Genes

CLCN2

Models

Trait associations