TWAS hub - KLHL6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0644	0.0273	1.3e-03	-0.001	0.016	0.012	0.016	-0.002	4.5e-01	1.6e-03	6.1e-03	1.4e-03	7.7e-01
2	YFS	Blood	0.0579	0.0149	8.4e-11	0.036	0.033	0.042	0.035	0.039	8.0e-12	3.5e-11	1.3e-13	9.0e-12	7.6e-13
3	TCGA	Brain Lower Grade Glioma	0.0571	0.0241	2.3e-04	0.054	0.024	0.047	NA	0.046	9.2e-07	7.6e-04	4.3e-06	NA	5.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	9.4	109.5	158.8	-10.3	-12.6	8.0
Handedness (chirality/laterality): Left-handed	6.8	8.2	12.2	1.5	3.2	-3.5
Type 2 Diabetes (T2D) (2012)	5.0	5.8	9.6	-1.5	2.3	-3.1
Commuting to job workplace: Walk	3.8	4.1	6.1	2.0	2.5	-1.5
Type 2 Diabetes (T2D) (2018)	3.7	7.0	10.4	3.1	3.2	-0.8
Length of working week for main job	3.2	3.5	10.4	3.2	0.4	0.1
Eye problems/disorders: Cataract	3.2	3.7	6.5	-2.5	0.7	-2.0
Prostate Cancer	2.9	4.0	8.1	-1.4	-2.9	1.4
Diabetes (mother)	2.7	3.5	5.3	1.5	2.3	-1.7
Illnesses of siblings	2.7	3.8	6.7	0.1	-2.2	2.6
Shortness of breath walking on level ground	2.7	3.2	3.7	-1.7	1.9	-1.6
Commuting to job workplace: Car/motor vehicle	2.6	3.0	4.7	-0.4	-2.0	2.2
Ulcerative Colitis	2.5	3.6	5.0	-2.2	-2.2	1.0
Arm fat percentage (right)	2.5	9.9	22.0	1.2	4.7	-2.5
Loud music exposure frequency	2.5	2.8	5.1	-0.3	1.8	-2.3
Schizophrenia vs Biploar Disorder	2.4	3.2	5.3	0.0	2.1	-2.3
Ulcerative Colitis (UC)	2.4	4.5	5.3	-2.3	-2.3	1.8
Fasting Glucose	2.4	2.8	3.3	1.6	-1.6	1.8
Multivitamins +/- minerals	2.4	3.1	7.8	-2.8	-1.2	-0.2
Whole body fat mass	2.4	9.8	22.6	0.9	4.8	-2.5
Miserableness	2.4	4.2	9.5	-3.1	-1.8	0.1
Hearing difficulty/problems: Yes	2.3	3.5	4.8	2.2	2.2	-0.9
Trunk fat percentage	2.3	9.3	21.1	0.9	4.6	-2.5
Trunk fat mass	2.3	9.8	22.5	0.6	4.7	-2.6
Body fat percentage	2.3	9.1	20.4	0.8	4.5	-2.5
Leg fat mass (right)	2.3	8.8	19.5	1.0	4.4	-2.4
Number of full sisters	2.3	2.8	4.2	0.0	-2.0	2.0
Breast cancer (self-reported)	2.3	2.8	5.2	-1.0	1.5	-2.3
Ever smoked	2.3	4.0	9.8	-3.1	-1.3	0.7
Bipolar Disorder (2011)	2.2	2.2	4.8	-0.5	-2.2	1.2
Arm fat mass (right)	2.2	9.1	20.5	1.2	4.5	-2.3
High blood pressure (siblings)	2.2	3.1	4.5	0.9	2.0	-2.1
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.0	-2.0	-1.7	1.1
Arm fat percentage (left)	2.1	8.4	18.8	1.1	4.3	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.7	8.4	1.1	2.9	-2.1
Glaucoma (self-reported)	2.0	2.3	3.4	-0.8	-1.7	1.8
Smoking status: Previous	2.0	3.0	4.4	-2.1	-1.4	1.6
Arm fat mass (left)	2.0	8.0	18.3	1.1	4.3	-2.1
Basal cell carcinoma (self-reported)	2.0	2.3	3.1	1.7	1.6	-1.2
Leg fat mass (left)	2.0	7.9	18.0	1.1	4.2	-2.1
Lupus	1.9	2.9	5.9	0.7	-1.5	2.4
Neuroticism	1.9	4.5	10.9	-3.3	-1.6	-0.2
Pulse wave reflection index	1.9	2.3	2.8	1.7	-1.2	1.7
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	4.0	-0.5	-2.0	1.8
Illnesses of siblings: Diabetes	1.9	2.4	4.2	-0.5	1.6	-2.0
Eye problems/disorders: Glaucoma	1.9	2.3	3.6	-0.8	-1.9	1.6
Average weekly beer plus cider intake	1.9	2.7	6.1	2.5	1.4	-0.2
Hip circumference	1.8	7.6	17.2	0.6	4.1	-2.3
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.4	-0.5	1.1	-2.3
Depressed Affect (Nagel 2018)	1.7	3.6	9.8	-3.1	-0.9	-0.2
Severe depression (siblings)	1.7	1.9	3.1	1.0	-1.8	1.2
Blood clot in the leg (DVT)	1.7	2.1	5.3	-0.3	1.0	-2.3
Friendships satisfaction	1.7	2.1	2.8	-1.7	-1.6	1.0
Illnesses of father: High blood pressure	1.7	2.1	2.3	1.5	1.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	8.1	0.8	2.9	-1.4
Heart disease (mother)	1.6	2.0	4.0	1.0	-1.0	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	5.7	-2.4	0.2	-0.2
BMI	1.5	8.5	18.9	2.0	4.3	-1.6
Average weekly spirits intake	1.5	1.8	3.0	1.5	1.7	0.1
Vitamin and mineral supplements	1.5	2.1	5.6	2.4	0.7	0.4
Stomach or abdominal pain in last month	1.5	1.9	3.3	1.3	1.8	-0.8
Past tobacco smoking	1.5	2.7	5.2	2.3	1.1	-1.3
Body mass index (BMI)	1.4	5.9	13.1	1.6	3.6	-1.4
Neuroticism score	1.4	2.9	7.6	-2.7	-1.1	-0.3
Weight	1.4	7.1	17.1	0.6	4.1	-2.0
Hair/balding pattern: Pattern 3	1.4	2.1	3.0	-1.2	1.3	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	1.8	-1.3	-1.4	1.1
Medication: Allopurinol	1.4	1.8	3.6	0.1	-1.4	1.9
Loneliness, isolation	1.4	2.0	4.9	-2.2	0.3	-1.0
Had menopause	1.3	1.6	3.3	-0.7	1.0	-1.8
Time employed in main current job	1.3	1.5	2.1	1.5	0.9	-1.2
Leg fat percentage (right)	1.3	4.6	10.8	0.5	3.3	-1.6
Medication for cholesterol	1.3	1.9	4.5	-2.1	-1.1	0.2
Wears glasses or contact lenses	1.3	1.5	4.5	-2.1	-0.2	0.1
Medication: Blood pressure	1.3	2.4	6.6	2.6	0.7	0.5
Medication: Bendroflumethiazide	1.3	2.0	4.0	1.4	0.2	2.0
Risk taking	1.3	1.8	3.1	-0.5	-1.8	1.5
Age at First Birth	1.2	1.8	2.9	-0.8	-1.7	1.3
Qualifications: CSEs or equivalent	1.2	1.6	3.4	1.9	1.0	0.4
Waist circumference	1.2	4.2	9.7	0.1	3.1	-1.7
Diabetes (self-reported)	1.2	1.8	3.2	1.8	1.5	-0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.1	-0.9	-1.5	1.1
Diabetes diagnosed by doctor	1.2	1.9	3.1	1.7	1.8	0.1
Commuting to job workplace: Public transport	1.2	1.4	2.5	-1.6	0.8	-1.0
Bipolar Disorder (2018)	1.1	1.8	3.8	0.7	-1.9	1.1
Mean Putamen Volume	1.1	1.2	2.0	-1.4	-1.3	0.3
Neuroticism (2016)	1.1	1.5	2.6	-1.4	0.4	-1.6
Angina	1.1	1.4	3.0	-0.6	-0.9	1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.1	1.2	-0.4	1.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.7	0.7	1.7	0.4
Exposure to tobacco smoke at home	1.1	1.3	3.1	0.7	1.8	-0.5
Breastfed as a baby	1.1	1.4	2.9	-0.6	-1.7	0.9
Tense / ‘highly strung’	1.1	1.8	2.6	-1.5	-1.6	-0.6
Emphysema/chronic bronchitis	1.1	1.3	1.9	-1.4	1.1	-0.8
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.0	-1.4	1.1	-1.0
Leg fat percentage (left)	1.1	4.1	9.9	0.7	3.1	-1.4
Irritable Bowel Disease (IBD)	1.0	2.4	4.8	-2.2	-1.5	0.1
Waist Hip Ratio (WHR)	1.0	4.5	6.6	-2.6	-2.4	1.0
Respiratory disease	1.0	2.1	4.4	-2.1	-1.4	0.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.8	-1.7	-1.1	0.0
Systolic blood pressure, automated reading	1.0	2.8	6.3	2.5	1.4	0.4
Supplements: Zinc	1.0	1.1	1.3	-1.1	-1.0	1.0
Medication: Metformin	1.0	1.5	2.7	1.6	1.3	0.1
Townsend deprivation index at recruitment	1.0	1.4	3.5	-0.6	-0.7	1.9
Supplements: Glucosamine	1.0	1.3	3.5	-1.9	-0.7	-0.1
Hair/balding pattern: Pattern 4	1.0	2.4	3.8	1.9	0.1	1.9
Medication: Paracetamol	1.0	1.7	3.8	0.6	-1.0	2.0
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.1	-0.0	-1.3	1.4
Had major operations	1.0	1.1	1.5	1.2	-0.9	1.0
Illnesses of father: Heart disease	1.0	1.4	2.6	-0.1	1.3	-1.6
Average weekly champagne plus white wine intake	1.0	1.4	1.7	-1.3	-0.9	-1.3
Diastolic blood pressure, automated reading	1.0	3.1	8.5	2.9	0.5	0.7
Supplements: Calcium	1.0	1.0	2.5	-1.6	-0.8	0.0
Depression (Nagel 2018)	0.9	1.4	2.4	-1.3	-1.5	0.5
Crohns Disease (2012)	0.9	1.5	3.4	-1.8	-1.0	-0.4
Blood Eosinophil Count	0.9	7.3	11.4	-3.4	-3.0	1.2
Leg fat-free mass (left)	0.9	4.5	10.9	0.8	3.3	-1.4
Fed-up feelings	0.9	1.6	4.2	-2.1	-0.6	0.6
Relative age voice broke	0.9	1.4	2.6	-1.6	-0.8	1.0
High blood pressure	0.9	2.5	6.1	2.5	1.1	0.4
Chronic bronchitis/emphysema (father)	0.9	1.0	2.4	-0.2	1.6	-0.8
Hearing difficulty/problems with background noise	0.9	1.4	2.3	1.4	1.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-1.1	0.3	-1.5
Medication: Cholesterol lowering	0.9	1.4	2.0	-0.9	-1.2	1.4
Lung cancer (father)	0.9	1.0	2.7	0.4	1.7	-0.4
Eye problems/disorders: None of the above	0.9	1.1	1.9	1.4	1.1	0.0
Medication: Seretide 50 evohaler	0.9	1.0	1.4	-1.2	-1.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.4	0.7	-1.2	1.1
Ever had bowel cancer screening	0.9	1.0	1.4	-0.9	-0.9	1.2
Cholesterol lowering medication	0.9	1.3	3.0	1.7	0.8	-0.4
Reaction Time	0.8	1.5	1.7	1.3	1.1	-1.3
Body Mass Index (BMI) (2010)	0.8	1.2	2.3	1.5	1.0	0.5
Blood White Count	0.8	5.9	12.1	-3.5	-2.3	-0.2
Systolic Blood Pressure	0.8	4.1	9.1	3.0	1.6	0.7
Cardiovascular Disease	0.8	2.8	7.4	2.7	0.9	0.3
Leg predicted mass (left)	0.8	4.5	10.9	0.8	3.3	-1.4
Depression (self-reported)	0.8	0.9	1.3	-1.1	-0.6	-1.0
Pulse wave peak to peak time	0.8	0.9	1.2	-0.6	1.1	-1.1
Health satisfaction	0.8	1.1	3.1	0.3	1.8	0.1
Neck or shoulder pain in last month	0.8	1.2	2.7	-1.6	0.2	0.9
Overall health rating	0.8	1.8	3.9	1.1	2.0	-0.5
Hypertension (Self-reported)	0.8	2.2	5.7	2.4	0.5	0.9
Commuting to job workplace: Cycle	0.8	1.0	1.5	1.2	-1.0	0.7
Alcohol drinker status: Previous	0.8	0.9	1.3	-1.1	-1.0	0.7
Neuroticism (Nagel 2018)	0.7	1.7	4.0	-2.0	-0.9	-0.5
Worry (Nagel 2018)	0.7	1.5	3.8	-1.9	-0.8	-0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.3	0.9	-1.0	1.1
Smoking Status	0.7	1.8	3.1	-1.8	-1.2	0.9
Hand grip strength (left)	0.7	1.9	3.1	-0.4	1.8	-1.6
Number of treatments/medications taken	0.7	1.2	2.5	-0.0	-1.1	1.6
Relative age of first facial hair	0.7	1.3	1.8	-0.7	-1.3	1.4
Number of incorrect matches in round	0.7	1.1	1.8	-1.1	-1.4	0.5
Hair/balding pattern: Pattern 2	0.7	0.9	1.2	-1.1	-1.1	0.6
Worrier / anxious feelings	0.7	1.3	3.2	-1.8	-0.8	0.2
Pulse wave Arterial Stiffness index	0.7	0.9	1.3	0.6	-1.1	1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.1	1.5	0.8	0.6
Birth weight	0.7	1.6	3.6	-0.7	1.9	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.1	-1.0	-0.7	-1.1
Angina (self-reported)	0.7	1.0	2.0	-0.6	-0.7	1.4
Chest pain or discomfort	0.7	1.0	2.3	-0.3	1.5	-0.7
Medication: Aspirin	0.7	0.9	1.8	0.8	-0.6	1.3
Knee pain experienced in last month	0.7	1.0	2.1	0.9	1.4	-0.4
Leg fat-free mass (right)	0.7	3.7	8.8	0.7	3.0	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	0.2	-0.7	1.3
Qualifications: nursing, teaching	0.7	1.1	1.8	0.2	-1.2	1.4
Back pain experienced in last month	0.7	1.0	2.2	-1.5	0.8	-0.4
Osteoporosis (self-reported)	0.7	0.8	1.3	-0.5	1.1	-0.9
Medication: Gliclazide	0.7	0.8	1.2	1.1	0.3	1.0
Leg predicted mass (right)	0.7	4.0	9.3	0.8	3.1	-1.4
Medication: Lisinopril	0.7	0.9	2.3	0.5	0.5	-1.5
Blood Red Count	0.6	5.7	10.6	3.2	2.4	-0.8
Medication for hormone replacement therapy	0.6	0.6	1.0	1.0	0.9	-0.4
Medication: Ramipril	0.6	0.8	1.3	1.0	1.1	0.2
Fluid intelligence score	0.6	1.2	2.7	-0.9	0.2	-1.6
Happiness	0.6	0.7	1.4	-0.2	1.2	-0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	-1.2	0.2	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	-1.2	0.8	0.0
Mood swings	0.6	1.1	2.4	-1.5	-0.9	0.2
Osteoarthritis (self-reported)	0.6	0.8	1.3	0.9	0.6	-1.1
Medication: Aspirin	0.6	0.7	1.4	0.7	-0.5	1.2
Medication: Atorvastatin	0.6	0.7	1.9	1.4	0.3	0.3
Basal metabolic rate	0.6	3.5	9.1	0.4	3.0	-1.2
Arm fat-free mass (left)	0.6	2.8	7.0	0.6	2.6	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.2	3.2	0.7	-1.8	0.2
Crohns Disease (2017)	0.5	1.1	2.4	-1.0	-0.0	-1.6
Rheumatoid Arthritis	0.5	0.7	1.0	-0.5	-1.0	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-0.7	-1.1	0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.2	0.6	1.1	-0.3
Alcohol usually taken with meals	0.5	0.8	1.7	-1.3	-0.1	-0.9
Mouth/teeth dental problems	0.5	0.8	1.5	0.1	1.2	-1.0
Medication: Simvastatin	0.5	0.7	1.4	-1.2	-0.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.1	-1.4	-0.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.2	-0.2	-1.5	-0.2
Birth weight of first child	0.5	0.9	1.9	0.7	1.4	-0.4
Gout (self-reported)	0.5	0.7	1.3	0.6	-0.8	1.1
Number of children fathered	0.5	0.6	1.4	0.0	-0.5	1.2
Mineral and other dietary supplements	0.5	0.7	1.7	1.3	0.2	0.6
Whole body water mass	0.5	2.7	6.8	0.4	2.6	-1.1
Ever taken oral contraceptive pill	0.5	0.6	0.8	-0.9	-0.9	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.8	-0.9	0.3	-0.8
Fractured/broken bones in last 5 years	0.5	0.6	0.9	0.9	0.8	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.6	-1.9	-0.4	-0.7
Arm predicted mass (left)	0.5	2.7	6.5	0.9	2.5	-0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.9	-1.0	-1.4	0.1
LDL Cholesterol	0.4	0.6	1.4	-0.7	0.2	-1.2
Triglycerides	0.4	0.6	1.4	1.2	-0.1	-0.6
Allergy or Eczema	0.4	1.0	1.2	-1.0	-1.1	0.8
Sensitivity / hurt feelings	0.4	0.8	1.5	-0.4	-1.2	0.8
Diabetes (father)	0.4	0.5	0.9	-0.5	-0.9	0.6
Maternal smoking around birth	0.4	0.6	1.0	0.1	1.0	-0.8
Taking other prescription medications	0.4	0.5	0.7	-0.8	-0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	0.2	0.2	-1.3
Falls in the last year	0.4	0.5	1.4	0.1	-0.4	1.2
Medication: Lansoprazole	0.4	0.4	1.0	0.4	0.3	1.0
Arm fat-free mass (right)	0.4	2.2	5.3	0.7	2.3	-0.9
Exposure to tobacco smoke outside home	0.4	0.6	1.6	-0.2	1.2	0.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	0.4	-0.8	1.1
Age at first live birth	0.4	0.7	1.3	-0.6	0.7	-1.1
Qualifications: College or University degree	0.4	1.2	2.9	-0.6	-1.7	0.6
Suffer from ‘nerves’	0.4	0.6	0.7	-0.7	-0.8	0.8
Whole body fat-free mass	0.4	2.4	6.3	0.3	2.5	-1.0
Asthma (self-reported)	0.4	0.8	1.4	-1.0	-1.2	0.0
Guilty feelings	0.4	0.5	0.8	-0.9	-0.2	-0.9
Medication: Paracetamol	0.4	0.6	1.1	0.7	0.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.2	-0.3	1.1	0.3
Pain experienced in last month	0.4	0.6	1.0	0.8	-1.0	-0.5
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	0.7	-0.8	0.2
Breast Cancer	0.3	0.8	1.8	-0.7	-0.1	1.3
Ovarian Cancer	0.3	0.4	0.6	0.4	-0.8	0.7
Heel T-Score	0.3	2.5	4.1	1.8	2.0	-0.5
Height	0.3	6.1	14.1	-3.8	1.0	-1.8
Ever had hysterectomy (womb removed)	0.3	0.3	0.4	0.4	0.6	-0.6
Impedance of leg (left)	0.3	1.3	2.3	-1.1	-1.5	0.6
Forced vital capacity (FVC)	0.3	1.0	1.6	-0.7	0.9	-1.3
Financial difficulties in last 2 years	0.3	0.4	0.5	0.6	0.7	-0.5
Number of live births	0.3	0.4	0.6	0.6	0.8	0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.8	1.4	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.4	0.6	-0.8
Asthma	0.3	0.5	0.8	-0.8	-0.9	-0.1
Prospective memory result	0.3	0.3	0.7	0.1	-0.5	0.8
Medication: Amlodipine	0.3	0.4	1.1	1.1	0.3	0.3
Worry too long after embarrassment	0.3	0.5	0.7	-0.9	0.1	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.6	1.6	0.0	0.3	-1.3
Medication: Blood pressure	0.3	0.4	1.1	1.1	0.5	0.1
Migraine (self-reported)	0.3	0.3	0.9	-0.3	-0.1	1.0
Medication: Omeprazole	0.3	0.4	1.1	-0.3	1.0	-0.2
Mean time to correctly identify matches	0.3	0.5	0.9	1.0	0.5	-0.6
Comparative height size at age 10	0.3	1.7	3.3	-1.3	1.8	0.1
Age at last live birth	0.3	0.4	0.7	-0.9	0.5	-0.4
Leg pain on walking	0.3	0.4	0.9	-0.5	1.0	-0.1
Average weekly red wine intake	0.3	0.5	0.9	-1.0	0.1	-0.7
Mother’s age at death	0.3	0.4	0.7	-0.4	-0.9	0.5
High cholesterol (Self-reported)	0.3	0.5	0.9	1.0	-0.1	0.7
Heart disease (siblings)	0.3	0.4	0.9	0.9	-0.4	0.3
Schizophrenia (2018)	0.2	0.4	0.5	0.4	-0.7	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.0	-0.6	0.4
Major Depression (MDD)	0.2	0.3	0.4	0.5	0.4	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.6	-0.3	0.4	-0.8
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.7	-0.4	0.4
Schizophrenia (2014)	0.2	0.4	0.7	0.4	-0.8	-0.6
Chronotype (morning person)	0.2	0.4	0.9	-1.0	0.3	-0.2
Tanning	0.2	2.5	5.8	-2.4	-1.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.9	0.3	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.5	-0.5	0.4
Impedance of leg (right)	0.2	1.1	1.7	-1.1	-1.3	0.6
Current tobacco smoking	0.2	0.3	0.5	-0.7	-0.6	0.0
Average weekly fortified wine intake	0.2	0.2	0.6	-0.2	-0.3	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.7	-0.4	-0.1
Medication: Levothyroxine sodium	0.2	0.4	0.8	0.1	0.5	-0.9
Sitting height	0.2	1.1	3.4	-1.9	-0.1	-0.0
Nervous feelings	0.2	0.4	0.6	-0.7	0.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.5	0.3	-0.7
Pain all over the body in last month	0.2	0.2	0.5	0.4	-0.1	0.7
Trunk fat-free mass	0.2	1.3	3.2	-0.3	1.8	-0.8
Father’s age at death	0.2	0.3	0.5	0.4	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.1	-0.7	0.9	-1.1
Noisy workplace	0.2	0.3	0.8	0.2	-0.1	0.9
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	-0.3	-1.0	-0.1
Illnesses of mother	0.2	0.3	0.8	-0.9	0.2	-0.2
Trunk predicted mass	0.2	1.4	3.4	-0.4	1.8	-0.8
Standing height	0.2	2.4	4.2	-2.0	1.2	-1.2
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.9	0.5	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	0.8	0.0	-0.4
Headache pain in last month	0.2	0.4	1.1	0.0	-0.3	1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.1	0.6	-0.8
Comparative body size at age 10	0.2	0.5	1.3	-1.1	-0.5	-0.2
Arm predicted mass (right)	0.2	1.3	3.4	0.1	1.8	-0.6
Pulse rate, automated reading	0.2	0.7	2.1	-0.3	-1.4	0.1
Alcohol intake frequency.	0.2	0.5	1.1	-0.4	1.1	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.5	0.7	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.4	0.6	0.5	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.2	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	0.8	-0.3	0.7
Alcohol drinker status: Never	0.2	0.2	0.4	0.4	0.0	0.7
Irritability	0.2	0.3	0.4	-0.7	-0.6	0.0
Age started oral contraceptive pill	0.2	0.3	0.5	0.3	-0.5	-0.7
Ever depressed for a whole week	0.2	0.2	0.5	0.7	-0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.5	-0.5	-0.7
HbA1C	0.1	0.1	0.1	-0.4	-0.2	0.2
HDL Cholesterol	0.1	0.1	0.3	-0.2	0.1	0.5
Hypothyroidism (self reported)	0.1	0.1	0.3	-0.3	-0.0	0.5
Medication: Co-codamol	0.1	0.1	0.2	-0.2	0.4	-0.0
Hand grip strength (right)	0.1	0.4	0.9	-0.9	0.4	-0.4
Age when periods started (menarche)	0.1	0.2	0.3	-0.6	0.4	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.3	-0.2	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.4	0.1	0.5
Medication: Atenolol	0.1	0.1	0.3	0.6	-0.2	0.2
High blood pressure (mother)	0.1	0.1	0.2	-0.1	-0.5	0.3
Had other major operations	0.1	0.2	0.3	-0.3	-0.4	-0.5
Heart attack	0.1	0.2	0.3	0.6	-0.1	0.4
Allergy	0.1	0.3	0.9	1.0	0.2	-0.0
Impedance of arm (right)	0.1	0.6	0.9	-0.8	0.4	-0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.6	0.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.5	-0.1	-0.2
Impedance of arm (left)	0.1	0.5	1.0	-1.0	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	0.4	0.8	-0.2
Number of full brothers	0.1	0.1	0.4	-0.0	0.1	-0.7
Family relationship satisfaction	0.1	0.1	0.3	-0.4	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.7	-0.3	0.4	-0.8
Smoking status: Current	0.1	0.1	0.3	-0.5	0.1	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.5	-0.1	0.6
Financial situation satisfaction	0.1	0.2	0.4	-0.1	0.3	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.3	-0.5	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.3	-0.2	-0.5
Number of operations (self-reported)	0.1	0.1	0.2	0.4	0.2	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.4	0.1	-0.2	0.6
Myopia	0.1	0.1	0.2	0.2	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.4	-0.3	0.3
Impedance of whole body	0.1	0.6	1.1	-1.0	-0.8	-0.1
Lung FEV1/FVC ratio	0.0	0.2	0.4	0.2	0.6	-0.4
Lung FVC	0.0	0.1	0.3	0.0	0.4	-0.5
Hair Pigment	0.0	1.3	3.2	0.5	1.8	-0.7
Pack years adult smoking proportion	0.0	0.0	0.1	0.3	-0.1	-0.0
Qualifications: None of the above	0.0	0.1	0.1	-0.1	0.3	0.3
Pulse rate	0.0	0.1	0.1	0.3	0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.2	0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.2	0.1	-0.1
Medication: Ibuprofen	0.0	0.1	0.1	-0.3	-0.2	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.2	0.2	0.1
Supplements: Vitamin C	0.0	0.0	0.1	-0.0	-0.1	0.2
Hearing aid user	0.0	0.0	0.1	0.1	0.1	-0.3
Pack years of smoking	0.0	0.0	0.0	-0.1	0.2	-0.2

Hub : Genes

KLHL6

Models

Trait associations