Hub : Genes

KLHL6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0644 0.0273 1.3e-03 -0.001 0.016 0.012 0.016 -0.002 4.5e-01 1.6e-03 6.1e-03 1.4e-03 7.7e-01
2 YFS Blood 0.0579 0.0149 8.4e-11 0.036 0.033 0.042 0.035 0.039 8.0e-12 3.5e-11 1.3e-13 9.0e-12 7.6e-13
3 TCGA Brain Lower Grade Glioma 0.0571 0.0241 2.3e-04 0.054 0.024 0.047 NA 0.046 9.2e-07 7.6e-04 4.3e-06 NA 5.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.1 1.8 3.8 0.7 -1.9 1.1
Bipolar Disorder or Schizophrenia 0.5 1.2 3.2 0.7 -1.8 0.2
Depressed Affect (Nagel 2018) 1.7 3.6 9.8 -3.1 -0.9 -0.2
Depression (Nagel 2018) 0.9 1.4 2.4 -1.3 -1.5 0.5
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.4 -0.5 -0.5 -0.7
Neuroticism (Nagel 2018) 0.7 1.7 4.0 -2.0 -0.9 -0.5
Schizophrenia (2018) 0.2 0.4 0.5 0.4 -0.7 -0.6
Schizophrenia vs Biploar Disorder 2.4 3.2 5.3 0.0 2.1 -2.3
Worry (Nagel 2018) 0.7 1.5 3.8 -1.9 -0.8 -0.3
Alzheimer’s Disease (in mother) 0.3 0.4 0.6 0.7 -0.8 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.3 0.0 -0.6 0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 1.3 0.9 -1.0 1.1
Crohns Disease (2017) 0.5 1.1 2.4 -1.0 -0.0 -1.6
Irritable Bowel Disease (IBD) 1.0 2.4 4.8 -2.2 -1.5 0.1
Ulcerative Colitis (UC) 2.4 4.5 5.3 -2.3 -2.3 1.8
Major Depression (MDD) 0.2 0.3 0.4 0.5 0.4 -0.6
Reaction Time 0.8 1.5 1.7 1.3 1.1 -1.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.9 -1.0 -1.4 0.1
Breast Cancer 0.3 0.8 1.8 -0.7 -0.1 1.3
Ovarian Cancer 0.3 0.4 0.6 0.4 -0.8 0.7
Prostate Cancer 2.9 4.0 8.1 -1.4 -2.9 1.4
Age at First Birth 1.2 1.8 2.9 -0.8 -1.7 1.3
Bipolar Disorder (2011) 2.2 2.2 4.8 -0.5 -2.2 1.2
Body Mass Index (BMI) (2010) 0.8 1.2 2.3 1.5 1.0 0.5
Coronary Artery Disease (CAD) 0.2 0.3 0.6 -0.3 0.4 -0.8
Crohns Disease (2012) 0.9 1.5 3.4 -1.8 -1.0 -0.4
Mean Putamen Volume 1.1 1.2 2.0 -1.4 -1.3 0.3
Fasting Glucose 2.4 2.8 3.3 1.6 -1.6 1.8
HbA1C 0.1 0.1 0.1 -0.4 -0.2 0.2
HDL Cholesterol 0.1 0.1 0.3 -0.2 0.1 0.5
LDL Cholesterol 0.4 0.6 1.4 -0.7 0.2 -1.2
Lupus 1.9 2.9 5.9 0.7 -1.5 2.4
Neuroticism (2016) 1.1 1.5 2.6 -1.4 0.4 -1.6
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.7 -0.4 0.4
Rheumatoid Arthritis 0.5 0.7 1.0 -0.5 -1.0 0.9
Schizophrenia (2014) 0.2 0.4 0.7 0.4 -0.8 -0.6
Triglycerides 0.4 0.6 1.4 1.2 -0.1 -0.6
Type 2 Diabetes (T2D) (2012) 5.0 5.8 9.6 -1.5 2.3 -3.1
Ulcerative Colitis 2.5 3.6 5.0 -2.2 -2.2 1.0
Blood Eosinophil Count 0.9 7.3 11.4 -3.4 -3.0 1.2
Blood Platelet Count 9.4 109.5 158.8 -10.3 -12.6 8.0
Blood Red Count 0.6 5.7 10.6 3.2 2.4 -0.8
Blood White Count 0.8 5.9 12.1 -3.5 -2.3 -0.2
Heel T-Score 0.3 2.5 4.1 1.8 2.0 -0.5
BMI 1.5 8.5 18.9 2.0 4.3 -1.6
Height 0.3 6.1 14.1 -3.8 1.0 -1.8
Waist Hip Ratio (WHR) 1.0 4.5 6.6 -2.6 -2.4 1.0
Systolic Blood Pressure 0.8 4.1 9.1 3.0 1.6 0.7
Smoking Status 0.7 1.8 3.1 -1.8 -1.2 0.9
Allergy or Eczema 0.4 1.0 1.2 -1.0 -1.1 0.8
Cardiovascular Disease 0.8 2.8 7.4 2.7 0.9 0.3
Hypothyroidism (self reported) 0.1 0.1 0.3 -0.3 -0.0 0.5
Respiratory disease 1.0 2.1 4.4 -2.1 -1.4 0.4
Type 2 Diabetes (T2D) (2018) 3.7 7.0 10.4 3.1 3.2 -0.8
Lung FEV1/FVC ratio 0.0 0.2 0.4 0.2 0.6 -0.4
Lung FVC 0.0 0.1 0.3 0.0 0.4 -0.5
Neuroticism 1.9 4.5 10.9 -3.3 -1.6 -0.2
Chronotype (morning person) 0.2 0.4 0.9 -1.0 0.3 -0.2
Hair Pigment 0.0 1.3 3.2 0.5 1.8 -0.7
Tanning 0.2 2.5 5.8 -2.4 -1.2 0.6
Hand grip strength (left) 0.7 1.9 3.1 -0.4 1.8 -1.6
Number of treatments/medications taken 0.7 1.2 2.5 -0.0 -1.1 1.6
Average weekly spirits intake 1.5 1.8 3.0 1.5 1.7 0.1
Sensitivity / hurt feelings 0.4 0.8 1.5 -0.4 -1.2 0.8
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.8 -1.7 -1.1 0.0
Hearing difficulty/problems: Yes 2.3 3.5 4.8 2.2 2.2 -0.9
Relative age of first facial hair 0.7 1.3 1.8 -0.7 -1.3 1.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.8 -0.9 0.3 0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.1 -0.7 -1.1 0.5
Ever had hysterectomy (womb removed) 0.3 0.3 0.4 0.4 0.6 -0.6
Systolic blood pressure, automated reading 1.0 2.8 6.3 2.5 1.4 0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.5 -0.5 0.4
Angina 1.1 1.4 3.0 -0.6 -0.9 1.7
Medication for hormone replacement therapy 0.6 0.6 1.0 1.0 0.9 -0.4
Vitamin and mineral supplements 1.5 2.1 5.6 2.4 0.7 0.4
Supplements: Zinc 1.0 1.1 1.3 -1.1 -1.0 1.0
Medication: Co-codamol 0.1 0.1 0.2 -0.2 0.4 -0.0
Medication: Metformin 1.0 1.5 2.7 1.6 1.3 0.1
Diabetes (father) 0.4 0.5 0.9 -0.5 -0.9 0.6
Diabetes (mother) 2.7 3.5 5.3 1.5 2.3 -1.7
Severe depression (siblings) 1.7 1.9 3.1 1.0 -1.8 1.2
Pack years adult smoking proportion 0.0 0.0 0.1 0.3 -0.1 -0.0
Impedance of leg (right) 0.2 1.1 1.7 -1.1 -1.3 0.6
Leg fat-free mass (left) 0.9 4.5 10.9 0.8 3.3 -1.4
Trunk fat percentage 2.3 9.3 21.1 0.9 4.6 -2.5
Hand grip strength (right) 0.1 0.4 0.9 -0.9 0.4 -0.4
Townsend deprivation index at recruitment 1.0 1.4 3.5 -0.6 -0.7 1.9
Current tobacco smoking 0.2 0.3 0.5 -0.7 -0.6 0.0
Average weekly fortified wine intake 0.2 0.2 0.6 -0.2 -0.3 -0.8
Maternal smoking around birth 0.4 0.6 1.0 0.1 1.0 -0.8
Fed-up feelings 0.9 1.6 4.2 -2.1 -0.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.7 -0.4 -0.1
Relative age voice broke 0.9 1.4 2.6 -1.6 -0.8 1.0
Taking other prescription medications 0.4 0.5 0.7 -0.8 -0.5 0.8
Age when periods started (menarche) 0.1 0.2 0.3 -0.6 0.4 -0.2
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.1 1.2 -0.4 1.5
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.6 8.1 0.8 2.9 -1.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.7 0.7 1.7 0.4
Qualifications: CSEs or equivalent 1.2 1.6 3.4 1.9 1.0 0.4
Serious illness, injury or assault to yourself 0.5 0.6 1.2 0.6 1.1 -0.3
High blood pressure 0.9 2.5 6.1 2.5 1.1 0.4
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.7 -0.3 -0.2 0.8
Multivitamins +/- minerals 2.4 3.1 7.8 -2.8 -1.2 -0.2
Stomach or abdominal pain in last month 1.5 1.9 3.3 1.3 1.8 -0.8
Supplements: Glucosamine 1.0 1.3 3.5 -1.9 -0.7 -0.1
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 0.4 0.1 0.5
Medication: Atenolol 0.1 0.1 0.3 0.6 -0.2 0.2
Medication: Levothyroxine sodium 0.2 0.4 0.8 0.1 0.5 -0.9
Sitting height 0.2 1.1 3.4 -1.9 -0.1 -0.0
Chronic bronchitis/emphysema (father) 0.9 1.0 2.4 -0.2 1.6 -0.8
High blood pressure (mother) 0.1 0.1 0.2 -0.1 -0.5 0.3
Body mass index (BMI) 1.4 5.9 13.1 1.6 3.6 -1.4
Impedance of leg (left) 0.3 1.3 2.3 -1.1 -1.5 0.6
Leg predicted mass (left) 0.8 4.5 10.9 0.8 3.3 -1.4
Trunk fat mass 2.3 9.8 22.5 0.6 4.7 -2.6
Waist circumference 1.2 4.2 9.7 0.1 3.1 -1.7
Number of incorrect matches in round 0.7 1.1 1.8 -1.1 -1.4 0.5
Past tobacco smoking 1.5 2.7 5.2 2.3 1.1 -1.3
Alcohol usually taken with meals 0.5 0.8 1.7 -1.3 -0.1 -0.9
Nervous feelings 0.2 0.4 0.6 -0.7 0.0 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.5 0.3 -0.7
Hearing difficulty/problems with background noise 0.9 1.4 2.3 1.4 1.5 -0.2
Hair/balding pattern: Pattern 2 0.7 0.9 1.2 -1.1 -1.1 0.6
Had menopause 1.3 1.6 3.3 -0.7 1.0 -1.8
Had other major operations 0.1 0.2 0.3 -0.3 -0.4 -0.5
Forced vital capacity (FVC) 0.3 1.0 1.6 -0.7 0.9 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.7 8.4 1.1 2.9 -2.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.2 -1.1 0.3 -1.5
Qualifications: None of the above 0.0 0.1 0.1 -0.1 0.3 0.3
Financial difficulties in last 2 years 0.3 0.4 0.5 0.6 0.7 -0.5
Mouth/teeth dental problems 0.5 0.8 1.5 0.1 1.2 -1.0
Heart attack 0.1 0.2 0.3 0.6 -0.1 0.4
Allergy 0.1 0.3 0.9 1.0 0.2 -0.0
Pain all over the body in last month 0.2 0.2 0.5 0.4 -0.1 0.7
Diabetes (self-reported) 1.2 1.8 3.2 1.8 1.5 -0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.6 0.2 0.2 -1.3
Medication: Ramipril 0.6 0.8 1.3 1.0 1.1 0.2
Medication: Simvastatin 0.5 0.7 1.4 -1.2 -0.7 0.4
Fluid intelligence score 0.6 1.2 2.7 -0.9 0.2 -1.6
Illnesses of siblings 2.7 3.8 6.7 0.1 -2.2 2.6
Neuroticism score 1.4 2.9 7.6 -2.7 -1.1 -0.3
Weight 1.4 7.1 17.1 0.6 4.1 -2.0
Impedance of arm (right) 0.1 0.6 0.9 -0.8 0.4 -0.9
Arm fat percentage (right) 2.5 9.9 22.0 1.2 4.7 -2.5
Trunk fat-free mass 0.2 1.3 3.2 -0.3 1.8 -0.8
Hip circumference 1.8 7.6 17.2 0.6 4.1 -2.3
Time employed in main current job 1.3 1.5 2.1 1.5 0.9 -1.2
Alcohol intake versus 10 years previously 0.1 0.1 0.3 -0.6 0.3 0.2
Father’s age at death 0.2 0.3 0.5 0.4 -0.4 -0.7
Worrier / anxious feelings 0.7 1.3 3.2 -1.8 -0.8 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 2.1 -1.4 -0.1 0.4
Falls in the last year 0.4 0.5 1.4 0.1 -0.4 1.2
Hair/balding pattern: Pattern 3 1.4 2.1 3.0 -1.2 1.3 -1.7
Number of live births 0.3 0.4 0.6 0.6 0.8 0.5
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.1 -0.7 0.9 -1.1
Pulse rate 0.0 0.1 0.1 0.3 0.2 0.2
Happiness 0.6 0.7 1.4 -0.2 1.2 -0.8
Noisy workplace 0.2 0.3 0.8 0.2 -0.1 0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.8 1.4 -0.2 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.7 0.4 0.6 -0.8
Mouth/teeth dental problems: Dentures 0.2 0.4 1.1 -0.3 -1.0 -0.1
Asthma 0.3 0.5 0.8 -0.8 -0.9 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 -0.5 -0.1 -0.2
Medication: Cholesterol lowering 0.9 1.4 2.0 -0.9 -1.2 1.4
Depression (self-reported) 0.8 0.9 1.3 -1.1 -0.6 -1.0
Medication: Lansoprazole 0.4 0.4 1.0 0.4 0.3 1.0
Prospective memory result 0.3 0.3 0.7 0.1 -0.5 0.8
Lung cancer (father) 0.9 1.0 2.7 0.4 1.7 -0.4
Illnesses of mother 0.2 0.3 0.8 -0.9 0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.2 0.5 0.1
Pulse wave Arterial Stiffness index 0.7 0.9 1.3 0.6 -1.1 1.0
Impedance of arm (left) 0.1 0.5 1.0 -1.0 -0.2 -0.6
Arm fat mass (right) 2.2 9.1 20.5 1.2 4.5 -2.3
Trunk predicted mass 0.2 1.4 3.4 -0.4 1.8 -0.8
Standing height 0.2 2.4 4.2 -2.0 1.2 -1.2
Length of working week for main job 3.2 3.5 10.4 3.2 0.4 0.1
Exposure to tobacco smoke at home 1.1 1.3 3.1 0.7 1.8 -0.5
Breastfed as a baby 1.1 1.4 2.9 -0.6 -1.7 0.9
Tense / ‘highly strung’ 1.1 1.8 2.6 -1.5 -1.6 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.2 -0.2 -1.5 -0.2
Hair/balding pattern: Pattern 4 1.0 2.4 3.8 1.9 0.1 1.9
Birth weight of first child 0.5 0.9 1.9 0.7 1.4 -0.4
Peak expiratory flow (PEF) 0.2 0.5 0.9 -0.9 0.5 -0.6
Pulse wave reflection index 1.9 2.3 2.8 1.7 -1.2 1.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 0.8 0.0 -0.4
Loud music exposure frequency 2.5 2.8 5.1 -0.3 1.8 -2.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 2.1 1.5 0.8 0.6
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 4.0 -0.5 -2.0 1.8
Blood clot in the leg (DVT) 1.7 2.1 5.3 -0.3 1.0 -2.3
Medication: Paracetamol 1.0 1.7 3.8 0.6 -1.0 2.0
Headache pain in last month 0.2 0.4 1.1 0.0 -0.3 1.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.7 -0.1 0.6 -0.8
Glaucoma (self-reported) 2.0 2.3 3.4 -0.8 -1.7 1.8
Gout (self-reported) 0.5 0.7 1.3 0.6 -0.8 1.1
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 0.2 0.1 -0.1
Medication: Amlodipine 0.3 0.4 1.1 1.1 0.3 0.3
Medication: Ventolin 100micrograms inhaler 1.0 1.2 2.1 -0.0 -1.3 1.4
Birth weight 0.7 1.6 3.6 -0.7 1.9 -0.8
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.1 -0.9 -1.5 1.1
High blood pressure (siblings) 2.2 3.1 4.5 0.9 2.0 -2.1
Forced vital capacity (FVC), Best measure 0.1 0.3 0.7 0.4 0.8 -0.2
Body fat percentage 2.3 9.1 20.4 0.8 4.5 -2.5
Leg fat percentage (right) 1.3 4.6 10.8 0.5 3.3 -1.6
Arm fat-free mass (right) 0.4 2.2 5.3 0.7 2.3 -0.9
Exposure to tobacco smoke outside home 0.4 0.6 1.6 -0.2 1.2 0.4
Comparative body size at age 10 0.2 0.5 1.3 -1.1 -0.5 -0.2
Number of full brothers 0.1 0.1 0.4 -0.0 0.1 -0.7
Worry too long after embarrassment 0.3 0.5 0.7 -0.9 0.1 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.1 -1.0 -0.7 -1.1
Wheeze or whistling in the chest in last year 0.4 0.7 1.2 0.4 -0.8 1.1
Number of children fathered 0.5 0.6 1.4 0.0 -0.5 1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 1.8 -1.3 -1.4 1.1
Age at first live birth 0.4 0.7 1.3 -0.6 0.7 -1.1
Pulse wave peak to peak time 0.8 0.9 1.2 -0.6 1.1 -1.1
Health satisfaction 0.8 1.1 3.1 0.3 1.8 0.1
Shortness of breath walking on level ground 2.7 3.2 3.7 -1.7 1.9 -1.6
Qualifications: College or University degree 0.4 1.2 2.9 -0.6 -1.7 0.6
Eye problems/disorders: None of the above 0.9 1.1 1.9 1.4 1.1 0.0
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.5 -1.2 0.2 0.7
Emphysema/chronic bronchitis 1.1 1.3 1.9 -1.4 1.1 -0.8
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 0.0 0.3 -1.3
Neck or shoulder pain in last month 0.8 1.2 2.7 -1.6 0.2 0.9
Medication: Blood pressure 0.3 0.4 1.1 1.1 0.5 0.1
Angina (self-reported) 0.7 1.0 2.0 -0.6 -0.7 1.4
Migraine (self-reported) 0.3 0.3 0.9 -0.3 -0.1 1.0
Medication: Ibuprofen 0.0 0.1 0.1 -0.3 -0.2 0.2
Medication: Allopurinol 1.4 1.8 3.6 0.1 -1.4 1.9
Medication: Omeprazole 0.3 0.4 1.1 -0.3 1.0 -0.2
Medication: Seretide 50 evohaler 0.9 1.0 1.4 -1.2 -1.2 0.5
Mean time to correctly identify matches 0.3 0.5 0.9 1.0 0.5 -0.6
Heart disease (mother) 1.6 2.0 4.0 1.0 -1.0 2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 -0.2 0.2 0.1
Whole body fat mass 2.4 9.8 22.6 0.9 4.8 -2.5
Leg fat mass (right) 2.3 8.8 19.5 1.0 4.4 -2.4
Arm predicted mass (right) 0.2 1.3 3.4 0.1 1.8 -0.6
Pulse rate, automated reading 0.2 0.7 2.1 -0.3 -1.4 0.1
Alcohol intake frequency. 0.2 0.5 1.1 -0.4 1.1 -0.3
Comparative height size at age 10 0.3 1.7 3.3 -1.3 1.8 0.1
Number of full sisters 2.3 2.8 4.2 0.0 -2.0 2.0
Suffer from ‘nerves’ 0.4 0.6 0.7 -0.7 -0.8 0.8
Overall health rating 0.8 1.8 3.9 1.1 2.0 -0.5
Chest pain or discomfort 0.7 1.0 2.3 -0.3 1.5 -0.7
Had major operations 1.0 1.1 1.5 1.2 -0.9 1.0
Age at last live birth 0.3 0.4 0.7 -0.9 0.5 -0.4
Family relationship satisfaction 0.1 0.1 0.3 -0.4 0.5 0.0
Leg pain on walking 0.3 0.4 0.9 -0.5 1.0 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.4 0.7 -1.2 1.1
Commuting to job workplace: Car/motor vehicle 2.6 3.0 4.7 -0.4 -2.0 2.2
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 4.0 -2.0 -1.7 1.1
Medication: Aspirin 0.7 0.9 1.8 0.8 -0.6 1.3
Supplements: Vitamin C 0.0 0.0 0.1 -0.0 -0.1 0.2
Knee pain experienced in last month 0.7 1.0 2.1 0.9 1.4 -0.4
Hypertension (Self-reported) 0.8 2.2 5.7 2.4 0.5 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.4 -1.2 0.8 0.0
Illnesses of father: Heart disease 1.0 1.4 2.6 -0.1 1.3 -1.6
Illnesses of siblings: Diabetes 1.9 2.4 4.2 -0.5 1.6 -2.0
Smoking status: Previous 2.0 3.0 4.4 -2.1 -1.4 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.7 -0.3 0.4 -0.8
Whole body fat-free mass 0.4 2.4 6.3 0.3 2.5 -1.0
Leg fat-free mass (right) 0.7 3.7 8.8 0.7 3.0 -1.3
Arm fat percentage (left) 2.1 8.4 18.8 1.1 4.3 -2.3
Average weekly red wine intake 0.3 0.5 0.9 -1.0 0.1 -0.7
Handedness (chirality/laterality): Left-handed 6.8 8.2 12.2 1.5 3.2 -3.5
Mood swings 0.6 1.1 2.4 -1.5 -0.9 0.2
Loneliness, isolation 1.4 2.0 4.9 -2.2 0.3 -1.0
Long-standing illness, disability or infirmity 0.2 0.3 0.5 -0.5 0.7 -0.4
Ever had bowel cancer screening 0.9 1.0 1.4 -0.9 -0.9 1.2
Diabetes diagnosed by doctor 1.2 1.9 3.1 1.7 1.8 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.7 0.2 -0.7 1.3
Friendships satisfaction 1.7 2.1 2.8 -1.7 -1.6 1.0
Qualifications: nursing, teaching 0.7 1.1 1.8 0.2 -1.2 1.4
Commuting to job workplace: Walk 3.8 4.1 6.1 2.0 2.5 -1.5
Eye problems/disorders: Cataract 3.2 3.7 6.5 -2.5 0.7 -2.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.4 0.6 0.5 -0.3
Medication for cholesterol 1.3 1.9 4.5 -2.1 -1.1 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 5.7 -2.4 0.2 -0.2
Back pain experienced in last month 0.7 1.0 2.2 -1.5 0.8 -0.4
Mineral and other dietary supplements 0.5 0.7 1.7 1.3 0.2 0.6
Breast cancer (self-reported) 2.3 2.8 5.2 -1.0 1.5 -2.3
Asthma (self-reported) 0.4 0.8 1.4 -1.0 -1.2 0.0
Osteoporosis (self-reported) 0.7 0.8 1.3 -0.5 1.1 -0.9
Osteoarthritis (self-reported) 0.6 0.8 1.3 0.9 0.6 -1.1
Medication: Aspirin 0.6 0.7 1.4 0.7 -0.5 1.2
Medication: Gliclazide 0.7 0.8 1.2 1.1 0.3 1.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.6 0.2 0.3 0.8
Smoking status: Current 0.1 0.1 0.3 -0.5 0.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.7 0.8 -0.3 0.7
Whole body water mass 0.5 2.7 6.8 0.4 2.6 -1.1
Leg predicted mass (right) 0.7 4.0 9.3 0.8 3.1 -1.4
Arm fat mass (left) 2.0 8.0 18.3 1.1 4.3 -2.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.5 -0.1 0.6
Average weekly champagne plus white wine intake 1.0 1.4 1.7 -1.3 -0.9 -1.3
Miserableness 2.4 4.2 9.5 -3.1 -1.8 0.1
Guilty feelings 0.4 0.5 0.8 -0.9 -0.2 -0.9
Wears glasses or contact lenses 1.3 1.5 4.5 -2.1 -0.2 0.1
Ever taken oral contraceptive pill 0.5 0.6 0.8 -0.9 -0.9 -0.3
Hearing aid user 0.0 0.0 0.1 0.1 0.1 -0.3
Mother’s age at death 0.3 0.4 0.7 -0.4 -0.9 0.5
Financial situation satisfaction 0.1 0.2 0.4 -0.1 0.3 -0.6
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.3 -0.5 -0.1
Commuting to job workplace: Public transport 1.2 1.4 2.5 -1.6 0.8 -1.0
Eye problems/disorders: Glaucoma 1.9 2.3 3.6 -0.8 -1.9 1.6
Medication: Blood pressure 1.3 2.4 6.6 2.6 0.7 0.5
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.0 -1.4 1.1 -1.0
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 0.3 -0.2 -0.5
High cholesterol (Self-reported) 0.3 0.5 0.9 1.0 -0.1 0.7
Medication: Bendroflumethiazide 1.3 2.0 4.0 1.4 0.2 2.0
Medication: Paracetamol 0.4 0.6 1.1 0.7 0.0 1.1
Medication: Lisinopril 0.7 0.9 2.3 0.5 0.5 -1.5
Medication: Atorvastatin 0.6 0.7 1.9 1.4 0.3 0.3
Illnesses of father: High blood pressure 1.7 2.1 2.3 1.5 1.5 -1.3
Alcohol drinker status: Never 0.2 0.2 0.4 0.4 0.0 0.7
Ever smoked 2.3 4.0 9.8 -3.1 -1.3 0.7
Basal metabolic rate 0.6 3.5 9.1 0.4 3.0 -1.2
Leg fat percentage (left) 1.1 4.1 9.9 0.7 3.1 -1.4
Arm fat-free mass (left) 0.6 2.8 7.0 0.6 2.6 -1.0
Number of operations (self-reported) 0.1 0.1 0.2 0.4 0.2 -0.2
Average weekly beer plus cider intake 1.9 2.7 6.1 2.5 1.4 -0.2
Irritability 0.2 0.3 0.4 -0.7 -0.6 0.0
Risk taking 1.3 1.8 3.1 -0.5 -1.8 1.5
Ever had prostate specific antigen (PSA) test 0.5 0.5 0.8 -0.9 0.3 -0.8
Fractured/broken bones in last 5 years 0.5 0.6 0.9 0.9 0.8 0.5
Age started oral contraceptive pill 0.2 0.3 0.5 0.3 -0.5 -0.7
Diastolic blood pressure, automated reading 1.0 3.1 8.5 2.9 0.5 0.7
Ever depressed for a whole week 0.2 0.2 0.5 0.7 -0.4 -0.3
Unable to work because of sickness or disability 0.1 0.1 0.4 0.1 -0.2 0.6
Commuting to job workplace: Cycle 0.8 1.0 1.5 1.2 -1.0 0.7
Myopia 0.1 0.1 0.2 0.2 0.5 0.3
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.6 -1.9 -0.4 -0.7
Cholesterol lowering medication 0.9 1.3 3.0 1.7 0.8 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.2 -0.3 1.1 0.3
Pain experienced in last month 0.4 0.6 1.0 0.8 -1.0 -0.5
Supplements: Calcium 1.0 1.0 2.5 -1.6 -0.8 0.0
Basal cell carcinoma (self-reported) 2.0 2.3 3.1 1.7 1.6 -1.2
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 0.4 -0.3 0.3
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 5.4 -0.5 1.1 -2.3
Heart disease (siblings) 0.3 0.4 0.9 0.9 -0.4 0.3
Alcohol drinker status: Previous 0.8 0.9 1.3 -1.1 -1.0 0.7
Pack years of smoking 0.0 0.0 0.0 -0.1 0.2 -0.2
Impedance of whole body 0.1 0.6 1.1 -1.0 -0.8 -0.1
Leg fat mass (left) 2.0 7.9 18.0 1.1 4.2 -2.1
Arm predicted mass (left) 0.5 2.7 6.5 0.9 2.5 -0.9