Hub : Genes

SPARCL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0790	0.0280	1.1e-04	0.021	0.039	0.009	0.040	0.025	1.3e-03	1.3e-05	2.3e-02	1.2e-05	3.9e-04
2	GTEx	Adipose Subcutaneous	0.0930	0.0330	5.5e-04	0.030	NA	0.027	NA	0.020	1.5e-03	NA	2.6e-03	NA	8.4e-03
3	GTEx	Artery Tibial	0.1129	0.0586	7.2e-03	0.073	NA	0.042	NA	0.091	2.1e-06	NA	3.0e-04	NA	1.2e-07
4	GTEx	Heart Left Ventricle	0.1366	0.0583	9.7e-03	0.003	NA	-0.003	NA	0.008	2.2e-01	NA	5.0e-01	NA	1.1e-01
5	GTEx	Nerve Tibial	0.1033	0.0395	1.7e-03	0.073	NA	0.055	NA	0.061	6.9e-06	NA	8.9e-05	NA	4.0e-05
6	GTEx	Skin Sun Exposed Lower leg	0.0630	0.0250	3.4e-03	0.068	NA	0.049	NA	0.071	2.5e-06	NA	6.8e-05	NA	1.7e-06
7	METSIM	Adipose	0.0566	0.0197	1.0e-04	0.011	0.023	0.017	0.022	0.018	7.2e-03	1.6e-04	1.2e-03	2.4e-04	8.5e-04
8	ROSMAP	Brain Pre-frontal Cortex	0.1691	0.0391	6.9e-09	0.109	0.076	0.077	0.090	0.101	6.6e-14	4.6e-10	3.5e-10	1.3e-11	6.2e-13
9	TCGA	Breast Invasive Carcinoma	0.0185	0.0095	2.2e-04	0.008	0.014	0.012	NA	0.008	6.2e-03	5.9e-04	1.4e-03	NA	6.0e-03
10	TCGA	Prostate Adenocarcinoma	0.0374	0.0175	2.6e-05	0.062	0.046	0.054	NA	0.058	4.8e-07	1.3e-05	2.5e-06	NA	9.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.1	0.2	1.2	-0.3	-0.3	-1.1	-0.0	-0.4	-0.0	-0.6	0.1	-0.2	-0.1
Bipolar Disorder or Schizophrenia	0.3	0.6	3.3	0.5	0.4	-1.8	0.9	-0.3	0.7	0.6	0.4	0.3	0.8
Depressed Affect (Nagel 2018)	1.5	3.1	6.8	-2.0	2.5	0.1	2.6	0.8	0.7	1.1	-2.1	2.2	1.3
Depression (Nagel 2018)	3.4	5.0	8.4	-0.2	2.7	2.8	2.9	2.5	1.5	2.1	-1.5	2.7	2.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.1	2.2	-0.1	0.4	-0.9	0.0	-0.6	-2.3	1.2	-1.0	-0.2
Neuroticism (Nagel 2018)	2.4	5.7	11.4	-2.7	2.9	1.1	3.4	2.0	1.9	2.1	-1.4	3.0	2.4
Schizophrenia (2018)	0.4	0.9	2.1	0.9	0.7	-1.4	1.2	-0.0	1.0	1.3	0.5	0.5	1.0
Schizophrenia vs Biploar Disorder	2.7	3.5	6.8	1.4	2.1	-0.3	2.3	1.5	2.4	2.0	1.3	1.9	2.6
Worry (Nagel 2018)	1.6	3.4	6.6	-2.4	2.0	0.6	2.6	1.5	1.5	1.9	-0.8	2.3	1.9
Alzheimer’s Disease (in mother)	1.6	1.9	3.8	-0.3	-2.0	-1.8	-1.3	-1.9	-1.3	0.5	-0.5	-1.5	-1.3
Alzheimer’s Disease (in father)	4.6	5.0	14.4	-0.6	-1.9	-1.1	-2.3	-2.0	-2.8	-3.8	-0.2	-2.6	-2.5
Alzheimer’s Disease (including proxy)	3.4	4.9	8.4	-0.1	-2.5	-2.2	-2.4	-2.8	-2.7	-1.7	-0.6	-2.9	-2.4
Crohns Disease (2017)	1.9	4.1	7.7	-0.8	-1.9	-1.2	-1.4	-2.3	-2.6	-2.2	-2.3	-1.8	-2.8
Irritable Bowel Disease (IBD)	0.2	0.4	1.8	0.1	-0.3	0.3	0.2	-0.1	-0.8	-1.3	-1.1	-0.2	-0.6
Ulcerative Colitis (UC)	0.7	1.4	3.0	0.3	1.0	1.3	1.5	1.7	1.1	0.0	0.2	1.4	1.5
Major Depression (MDD)	1.5	1.8	4.1	2.0	-0.9	0.1	-1.7	-0.9	-1.1	-1.2	-0.1	-1.8	-1.7
Reaction Time	0.7	1.3	8.1	-0.8	0.2	-0.7	0.7	-0.8	-1.4	0.1	-2.8	0.0	-0.5
Verbal and Numeric Reasoning (VNR)	1.2	2.9	9.4	3.1	0.3	-0.0	-1.6	-0.0	-0.1	-2.4	3.1	-1.4	-0.1
Breast Cancer	0.3	0.6	3.9	2.0	-0.3	0.3	-0.0	0.2	0.4	0.8	1.1	0.1	0.0
Ovarian Cancer	0.8	1.1	2.0	-1.3	0.9	1.0	1.4	1.1	1.1	1.0	-0.1	1.2	0.9
Prostate Cancer	1.5	2.1	5.0	-1.4	2.0	0.8	2.1	0.9	0.2	0.9	-2.2	1.7	0.9
Age at First Birth	0.3	0.4	0.9	0.9	0.7	0.7	-0.3	0.4	0.5	-1.0	0.7	-0.3	0.1
Bipolar Disorder (2011)	0.9	0.9	2.3	0.1	-1.1	-1.5	-0.4	-1.2	-0.6	-0.6	-1.5	-0.4	-0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.6	-0.0	0.8	-0.1	-0.1	0.5	0.9	-0.4	0.7	-0.5
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.7	0.8	-0.2	-0.3	-0.4	-0.9	-0.3	-0.6	-0.7	-0.7
Crohns Disease (2012)	1.0	1.5	3.9	0.1	-1.4	-0.7	-0.4	-1.2	-1.4	-1.8	-2.0	-0.6	-1.4
Mean Putamen Volume	0.3	0.4	1.1	-0.7	0.0	-0.1	0.1	0.7	0.9	0.4	1.1	0.4	0.9
Fasting Glucose	0.5	0.6	2.1	-1.4	-0.4	0.6	0.1	-0.3	-1.1	-0.3	-1.2	0.2	-0.8
HbA1C	2.0	2.2	4.2	-0.5	1.2	1.4	1.0	2.0	1.8	1.2	1.8	1.0	2.0
HDL Cholesterol	1.3	2.2	11.8	3.4	0.3	0.1	-0.6	0.4	0.6	-1.2	2.6	-0.6	0.7
LDL Cholesterol	0.7	1.0	7.2	-2.7	0.3	-1.1	0.4	-0.4	0.2	0.6	-0.9	0.5	0.0
Lupus	1.1	1.6	2.8	-1.0	1.0	0.7	1.4	1.3	1.6	1.4	-0.6	1.7	1.6
Neuroticism (2016)	1.4	2.0	6.4	-2.5	1.5	1.3	1.3	1.3	1.1	0.7	-1.0	1.7	0.9
Primary Biliary Cirrhosis	2.5	3.6	6.4	0.2	2.0	1.5	1.9	2.1	2.5	2.2	1.1	2.3	2.1
Rheumatoid Arthritis	0.3	0.4	2.2	0.0	-0.2	-1.5	-0.1	-1.1	-0.1	-0.6	-0.1	-0.1	-0.7
Schizophrenia (2014)	0.6	1.3	2.7	0.6	0.9	-1.6	1.3	0.1	1.4	1.5	0.2	1.0	1.4
Triglycerides	3.6	5.9	28.3	-5.3	1.4	0.9	2.4	0.8	1.4	2.6	-2.8	2.2	0.5
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.9	1.4	-2.0	-1.1	-1.2	-1.1	-0.6	-1.3	2.0	-1.2	-1.1
Ulcerative Colitis	0.3	0.5	2.1	1.1	-0.6	-0.1	-0.2	0.5	-0.1	-1.4	0.6	-0.3	0.6
Blood Eosinophil Count	0.2	1.4	3.6	-0.6	1.1	1.6	1.2	1.4	0.8	0.6	-0.9	1.9	0.9
Blood Platelet Count	0.5	5.8	27.7	-3.9	1.2	0.2	2.1	0.3	0.1	2.4	-5.3	1.8	0.5
Blood Red Count	0.5	5.2	20.9	4.6	-1.1	-0.7	-2.1	-1.4	-1.4	-3.2	1.6	-2.4	-1.6
Blood White Count	1.2	9.0	13.1	-3.5	3.6	2.9	2.8	3.4	2.5	2.9	-1.2	3.5	2.7
Heel T-Score	0.3	2.7	11.3	-3.4	-0.5	-2.1	1.8	-1.0	1.9	0.2	-0.5	1.2	1.3
BMI	0.1	0.8	3.6	-1.9	0.4	-0.1	-0.4	0.1	-0.1	-1.0	-1.6	0.6	-0.1
Height	0.1	2.7	6.1	0.6	1.7	1.4	0.9	2.3	1.5	-2.5	1.9	1.5	1.3
Waist Hip Ratio (WHR)	0.3	1.3	3.5	-1.2	1.9	0.4	0.9	1.0	1.0	0.7	1.4	0.9	1.3
Systolic Blood Pressure	0.2	1.0	2.3	-1.5	-0.3	0.0	-0.6	-0.7	-1.4	-0.8	-1.5	-0.8	-1.1
Smoking Status	0.1	0.2	1.1	0.5	0.1	-0.0	-0.4	0.1	0.3	-0.2	1.0	-0.2	0.1
Allergy or Eczema	0.3	0.7	2.0	-0.6	0.1	-1.4	-0.4	-1.2	-0.3	-0.5	-1.3	-0.7	-0.8
Cardiovascular Disease	0.2	0.5	2.1	-1.5	-0.3	0.7	-1.0	-0.1	-0.5	-0.4	-0.2	-0.7	-0.8
Hypothyroidism (self reported)	0.5	1.1	3.3	-1.6	1.2	0.2	0.5	0.4	1.0	1.8	-0.9	1.0	0.4
Respiratory disease	0.7	1.6	3.0	-0.0	1.6	1.1	1.7	1.5	1.6	0.6	0.1	1.7	1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.5	0.5	-0.4	-2.1	-0.5	-1.5	-0.4	-0.7	-0.8	-0.6	-0.9
Lung FEV1/FVC ratio	0.9	4.7	11.4	0.8	-2.0	-0.8	-2.2	-2.4	-3.4	-1.8	-1.3	-2.4	-3.1
Lung FVC	0.4	1.8	5.7	-2.1	0.2	0.0	1.3	0.6	1.3	2.4	-0.5	1.5	1.3
Neuroticism	1.3	3.0	6.1	-2.5	2.3	0.4	2.4	1.2	1.1	1.4	-1.2	2.1	1.6
Chronotype (morning person)	0.1	0.2	0.3	-0.4	-0.4	0.2	0.3	0.4	0.2	0.5	0.5	0.5	0.5
Hair Pigment	0.0	0.8	3.0	-0.5	-0.3	-1.7	-0.1	-1.1	-1.0	-0.8	-1.2	-0.1	-0.5
Tanning	0.2	1.9	4.7	-0.4	2.2	1.7	1.3	1.7	1.3	0.3	1.6	0.9	1.1
Hand grip strength (left)	0.1	0.2	1.0	1.0	0.1	0.3	-0.6	0.1	0.2	0.1	0.2	0.2	-0.3
Number of treatments/medications taken	0.2	0.4	1.5	-0.1	-0.7	-0.2	-0.5	-0.5	-1.2	-0.2	-0.4	-1.2	-0.6
Average weekly spirits intake	2.3	2.8	4.3	1.0	-1.4	-1.9	-1.6	-2.1	-2.0	-1.7	0.2	-2.0	-1.9
Sensitivity / hurt feelings	0.6	1.0	2.9	-1.2	0.3	-0.3	1.1	-0.1	0.1	1.7	-1.6	1.1	0.2
Frequency of depressed mood in last 2 weeks	3.8	5.3	10.4	-0.6	2.2	1.8	3.2	2.1	1.8	2.5	-2.3	3.2	2.2
Hearing difficulty/problems: Yes	1.1	1.6	5.3	1.9	-0.6	1.0	0.2	1.4	0.7	1.1	2.3	0.1	1.4
Relative age of first facial hair	0.4	0.7	3.3	-1.8	-0.2	0.4	-0.5	-0.3	-1.2	-0.7	-0.6	-0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.6	0.3	1.0	1.0	1.4	1.4	0.7	1.1	-0.6	1.6	1.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.7	1.0	-0.2	-0.5	-1.6	-1.0	-1.9	-1.7	-0.0	-1.8	-1.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	0.1	-1.0	-0.6	-1.0	-0.6	0.1	-0.4	1.0	-0.6	-0.4
Systolic blood pressure, automated reading	0.2	0.5	3.3	-1.1	0.2	-0.1	0.3	-0.1	-0.2	0.0	-1.8	0.1	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.5	-0.7	0.1	1.2	0.5	0.8	0.1	-0.4	-0.4	0.8	0.2
Angina	1.6	2.1	3.8	0.9	-0.7	-1.4	-1.8	-1.9	-1.6	-1.0	0.3	-1.7	-2.0
Medication for hormone replacement therapy	0.4	0.5	3.0	1.7	0.4	0.5	-0.0	0.5	0.3	0.8	0.7	-0.2	0.5
Vitamin and mineral supplements	2.1	2.8	5.4	-1.1	1.7	2.3	0.8	2.3	2.0	1.5	-0.2	1.9	1.7
Supplements: Zinc	0.7	0.7	3.6	1.9	0.6	-0.3	0.8	0.3	0.9	0.5	0.6	0.3	0.9
Medication: Co-codamol	0.5	0.6	1.3	0.3	-0.2	0.7	-0.8	-0.4	-1.1	-0.6	-0.2	-1.1	-1.1
Medication: Metformin	0.3	0.4	2.0	1.4	-0.5	-0.7	-0.4	-0.3	0.4	0.3	1.0	-0.2	0.1
Diabetes (father)	1.4	1.7	2.9	1.4	-1.4	-0.8	-1.7	-1.0	-1.4	-1.5	0.5	-1.6	-1.2
Diabetes (mother)	0.9	1.2	4.2	2.0	0.6	1.2	-0.7	0.9	0.5	-0.3	1.7	-0.8	0.6
Severe depression (siblings)	0.2	0.2	0.8	0.9	-0.0	-0.6	-0.2	-0.2	0.5	0.4	0.7	0.3	0.1
Pack years adult smoking proportion	1.4	2.1	4.5	-0.9	2.1	1.9	1.4	2.1	0.7	0.2	-0.7	1.3	1.7
Impedance of leg (right)	0.2	0.8	1.9	1.0	-1.4	-0.6	0.3	-1.1	-1.1	0.6	-0.2	-1.0	-0.7
Leg fat-free mass (left)	0.2	0.9	2.2	-0.9	1.4	0.6	-0.1	1.1	0.8	-1.5	-0.4	1.1	0.5
Trunk fat percentage	0.2	0.8	1.7	-0.7	0.7	-0.0	1.0	0.7	1.3	0.6	-0.8	1.3	1.0
Hand grip strength (right)	0.0	0.1	0.5	0.3	0.7	-0.2	-0.4	-0.0	0.3	-0.0	-0.4	0.5	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.1	0.1	0.7	0.3	0.6	0.4	0.5	-0.5	0.4	0.5
Current tobacco smoking	0.5	0.7	1.6	-0.5	1.3	0.7	0.9	1.0	0.9	0.8	-0.6	0.9	0.9
Average weekly fortified wine intake	0.3	0.4	1.5	1.2	0.1	0.8	-0.5	0.0	-0.3	-0.6	0.4	-0.5	-0.5
Maternal smoking around birth	0.5	0.7	2.3	-1.1	0.3	1.5	0.5	1.0	0.7	0.4	-0.2	1.1	0.4
Fed-up feelings	0.7	1.3	3.1	-1.7	1.8	-0.1	1.5	0.4	0.8	0.1	-1.2	1.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.8	-1.2	1.6	1.8	1.9	1.4	0.5	1.9	-1.9	1.8	1.0
Relative age voice broke	1.4	2.1	4.6	-0.0	-1.2	-0.4	-1.6	-1.3	-2.1	-2.0	-0.5	-1.8	-1.8
Taking other prescription medications	0.5	0.8	1.8	-0.6	1.4	0.4	1.2	0.9	0.6	1.1	-0.5	0.7	1.0
Age when periods started (menarche)	1.4	3.4	7.7	-0.9	1.6	1.9	2.0	2.1	1.6	2.8	0.8	2.1	1.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.1	1.7	-0.0	1.4	-0.4	1.0	0.5	-0.8	1.8	-0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	5.3	-2.3	-0.9	-0.9	-0.1	-1.0	0.8	0.2	-1.1	0.3	-0.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.5	-1.2	1.3	1.5	0.9	1.6	0.7	1.4	-0.7	0.9	1.0
Qualifications: CSEs or equivalent	0.7	0.9	5.6	-1.3	0.8	0.1	0.4	-0.3	-0.8	0.6	-2.4	0.3	-0.4
Serious illness, injury or assault to yourself	0.7	0.8	3.5	-1.9	1.0	0.9	0.4	0.6	-0.3	-0.6	-1.4	0.3	0.0
High blood pressure	0.3	0.8	1.4	0.2	-0.9	-0.5	-1.1	-1.1	-0.8	-0.8	-0.4	-1.2	-1.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.3	-0.4	-0.1	-0.1	-0.5	-0.5	-0.4
Multivitamins +/- minerals	2.1	2.7	4.3	0.5	-1.6	-1.5	-1.4	-2.1	-2.0	-1.7	0.1	-2.0	-2.1
Stomach or abdominal pain in last month	0.8	1.0	2.1	1.1	0.9	0.6	1.4	1.2	0.8	0.6	0.3	0.9	1.5
Supplements: Glucosamine	2.7	3.6	10.4	0.8	-1.3	-0.0	-2.1	-1.2	-2.5	-3.2	0.3	-2.5	-2.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.2	-0.6	1.7	2.1	0.3	1.5	-0.0	-0.2	0.7	-0.1	0.6
Medication: Atenolol	1.7	2.1	4.9	-0.6	-1.5	-1.7	-1.2	-2.2	-1.5	-0.1	-1.7	-0.7	-2.0
Medication: Levothyroxine sodium	0.5	0.9	2.0	-1.4	1.2	0.4	0.6	0.6	0.9	1.3	-1.0	1.1	0.4
Sitting height	0.6	3.9	15.3	-3.9	2.3	1.1	1.3	2.0	1.1	-1.0	-1.4	2.6	0.9
Chronic bronchitis/emphysema (father)	0.8	0.9	1.8	0.2	1.1	0.7	1.3	1.0	1.3	-0.0	0.6	1.1	1.2
High blood pressure (mother)	0.3	0.4	1.0	0.3	-0.0	-1.0	-0.6	-0.8	-0.4	-0.8	0.0	-0.8	-0.5
Body mass index (BMI)	0.2	1.0	3.6	-1.9	1.1	0.2	0.4	0.5	0.8	0.4	-1.6	1.2	0.4
Impedance of leg (left)	0.2	1.0	2.8	1.1	-1.7	-0.8	-0.1	-1.1	-1.0	0.9	0.5	-1.1	-0.7
Leg predicted mass (left)	0.2	0.8	2.5	-0.9	1.3	0.5	-0.2	1.1	0.7	-1.6	-0.3	1.0	0.4
Trunk fat mass	0.2	0.9	2.1	-0.9	1.0	0.3	0.9	1.0	1.3	0.1	-0.6	1.5	1.0
Waist circumference	0.5	2.0	3.7	-1.9	1.7	1.0	0.9	1.5	1.6	0.6	-1.1	1.9	1.2
Number of incorrect matches in round	0.7	1.1	3.7	1.0	0.4	0.4	0.4	1.0	0.9	1.5	1.9	0.2	1.4
Past tobacco smoking	0.4	0.7	2.9	-0.9	0.5	0.5	1.1	0.2	-0.1	1.1	-1.7	0.7	0.0
Alcohol usually taken with meals	1.2	2.0	3.7	1.9	-1.4	-1.0	-1.7	-1.5	-1.0	-1.0	0.8	-1.6	-1.7
Nervous feelings	1.0	2.0	3.8	-1.7	1.3	0.0	2.0	1.0	1.3	1.9	-0.5	1.7	1.5
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	7.0	-2.0	2.2	0.8	2.6	1.1	0.9	2.2	-2.2	2.1	1.4
Hearing difficulty/problems with background noise	3.8	6.1	22.3	4.7	-1.8	-0.6	-2.3	-0.2	-0.8	-0.7	4.7	-2.6	0.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.3	0.2	0.7	-0.0	1.5	0.8	1.1	1.1	-0.1	1.2	1.1
Had menopause	1.3	1.7	8.5	1.6	-0.5	1.0	-0.8	1.1	0.9	0.7	2.9	-0.5	0.8
Had other major operations	0.5	0.6	2.5	0.1	0.8	1.1	0.3	0.4	-0.8	-1.6	-0.5	-0.1	-0.3
Forced vital capacity (FVC)	0.2	0.8	2.3	-1.4	0.6	0.1	0.7	0.6	1.1	0.5	-0.6	1.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	3.2	-1.8	-1.4	-1.2	-0.6	-1.6	0.3	-0.1	-1.4	-0.4	-0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.6	0.8	0.4	-0.3	0.1	-0.2	-0.2	-0.7	-0.1	-0.0	-0.1
Qualifications: None of the above	1.0	2.0	7.1	-2.7	0.4	0.7	1.6	1.1	0.6	2.0	-1.1	1.6	1.0
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.1	0.9	-0.9	0.5	-0.5	-0.1	0.5	-0.8	0.5	0.1
Mouth/teeth dental problems	0.3	0.5	1.9	-1.4	-0.1	-1.4	0.0	-0.9	-0.3	-0.4	-0.5	0.1	-0.5
Heart attack	1.6	2.1	3.3	1.6	-1.4	-1.5	-0.8	-1.8	-1.5	-1.4	-0.7	-1.6	-1.6
Allergy	0.1	0.3	0.6	-0.2	-0.0	0.7	0.3	0.8	0.2	0.3	0.7	0.3	0.7
Pain all over the body in last month	2.2	2.4	4.3	1.7	1.6	2.0	1.6	2.1	1.2	0.4	1.0	1.2	1.8
Diabetes (self-reported)	0.5	0.8	3.3	0.4	-0.0	-1.8	-0.4	-1.5	-0.5	-0.3	-0.5	-0.6	-1.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.4	1.3	-1.2	-1.3	-1.6	-1.0	-0.7	-0.9	1.4	-1.4	-0.6
Medication: Ramipril	0.6	0.8	1.7	-1.2	1.3	0.3	0.9	0.8	1.1	0.5	-0.2	0.7	1.0
Medication: Simvastatin	1.4	2.0	3.6	-0.5	-1.7	-1.2	-1.9	-1.5	-1.7	-1.1	0.3	-1.9	-1.4
Fluid intelligence score	1.0	2.1	4.3	2.1	-0.6	-1.4	-1.9	-1.3	-0.6	-1.6	1.6	-1.4	-1.1
Illnesses of siblings	0.4	0.6	1.5	-1.1	1.0	1.2	0.3	0.7	0.8	-0.1	-0.6	1.0	0.3
Neuroticism score	1.2	2.6	6.5	-1.2	2.1	0.2	2.6	1.0	1.4	1.7	-0.8	2.1	1.5
Weight	0.2	1.0	2.3	-1.5	1.2	0.5	0.4	1.1	1.0	-0.7	-0.9	1.4	0.6
Impedance of arm (right)	0.3	1.5	5.2	2.3	-1.9	-1.3	-0.2	-1.0	-0.4	0.2	1.3	-0.9	-0.2
Arm fat percentage (right)	0.2	0.7	1.4	-0.9	0.5	-0.1	0.7	0.5	1.1	0.9	-1.1	1.2	0.8
Trunk fat-free mass	0.1	0.8	5.0	-0.7	0.7	0.7	-0.9	0.7	0.0	-2.2	0.0	0.3	-0.3
Hip circumference	0.2	1.1	3.8	-1.3	0.8	0.2	0.6	0.7	1.0	-0.6	-1.9	1.5	0.4
Time employed in main current job	1.1	1.2	3.5	0.8	-0.8	0.6	-1.9	-0.6	-1.2	-0.8	-0.1	-1.5	-1.6
Alcohol intake versus 10 years previously	0.5	0.7	1.8	1.2	-0.6	-1.3	-0.5	-1.2	-0.7	0.6	-0.5	-0.3	-0.7
Father’s age at death	1.2	1.6	4.5	0.5	0.6	0.1	1.5	1.3	2.1	0.5	0.8	1.6	1.8
Worrier / anxious feelings	0.7	1.3	3.3	-1.2	1.3	0.7	1.8	0.9	0.6	0.6	-1.2	1.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	6.3	-0.6	0.6	1.9	0.3	0.6	-0.5	0.3	-2.5	0.7	-0.4
Falls in the last year	0.8	1.1	3.6	0.2	0.1	-0.2	-1.1	-0.8	-1.6	-1.9	-0.0	-1.5	-1.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.5	0.7	-0.3	-0.5	0.5	0.3	0.5	0.2	1.2	0.1	0.9
Number of live births	0.7	1.0	1.9	-0.2	-0.7	-0.9	-1.2	-1.0	-1.1	-1.4	0.4	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.4	-1.2	0.2	-0.4	0.3	-0.3	0.1	-0.1	-1.2	0.9	-0.3
Pulse rate	0.2	0.4	1.5	0.1	-0.1	-0.0	-0.7	-0.2	-1.0	-1.2	-0.1	-0.8	-0.4
Happiness	2.1	2.5	6.0	-1.3	2.0	0.8	2.4	1.6	1.4	1.2	0.0	1.9	1.8
Noisy workplace	0.4	0.4	1.7	0.0	-0.3	-1.3	-0.9	-1.1	-0.2	-0.0	-0.2	-0.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.7	1.2	-0.4	-0.9	-1.0	-0.6	-0.2	-1.9	1.4	-1.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.2	0.4	0.0	-1.5	-0.2	-0.8	0.8	0.0	0.4	-0.1	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.6	2.1	1.3	-1.4	0.2	-0.5	-0.3	-0.5	-0.1	-0.3	-0.9	-0.5
Asthma	0.2	0.3	0.7	0.8	0.7	0.7	0.2	0.5	0.6	-0.6	0.6	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	0.3	-0.8	-0.5	-0.3	-0.4	-0.8	-0.9	-0.3	-0.7	-0.2
Medication: Cholesterol lowering	2.1	3.2	7.1	-2.7	-1.5	-1.1	-1.1	-1.8	-2.3	-1.3	-2.1	-1.1	-2.1
Depression (self-reported)	0.8	1.0	3.1	-0.6	1.0	-0.1	0.7	1.0	1.8	1.2	0.6	0.8	1.4
Medication: Lansoprazole	0.7	0.8	2.2	-0.7	0.3	0.2	1.5	0.7	1.3	0.3	-0.3	1.3	0.8
Prospective memory result	1.1	1.4	4.2	-2.0	0.8	-1.2	1.4	0.0	1.6	0.4	-0.6	1.3	1.0
Lung cancer (father)	0.7	0.8	3.2	-1.8	1.3	-0.2	0.7	0.5	0.6	0.1	0.8	0.2	1.0
Illnesses of mother	0.3	0.3	0.8	-0.2	-0.4	-0.2	-0.6	-0.4	-0.8	-0.9	-0.8	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.1	-0.9	-0.5	-0.6	-0.3	-1.0	-0.4	-0.5	-1.4	0.1	-1.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	-0.3	0.2	0.5	-0.3	0.7	0.7	-1.1	0.8	0.1	0.6
Impedance of arm (left)	0.2	0.9	3.3	1.8	-1.5	-1.1	0.2	-0.8	-0.2	0.4	0.8	-0.8	-0.1
Arm fat mass (right)	0.2	1.0	2.4	-1.6	0.8	0.3	0.6	0.8	1.1	0.4	-1.3	1.5	0.8
Trunk predicted mass	0.1	0.8	4.6	-0.7	0.8	0.8	-0.8	0.8	0.1	-2.1	0.0	0.4	-0.2
Standing height	0.1	0.9	6.4	0.6	0.1	0.3	-0.2	0.8	0.2	-2.5	1.3	0.3	0.1
Length of working week for main job	0.3	0.3	1.0	1.0	-0.2	-0.8	-0.3	-0.5	-0.2	0.5	-0.5	-0.5	-0.1
Exposure to tobacco smoke at home	0.6	0.7	1.4	-0.1	-1.1	-1.0	-0.8	-1.2	-1.0	-0.2	-0.2	-0.5	-1.2
Breastfed as a baby	0.9	1.1	3.2	0.9	1.0	1.8	-0.1	1.3	0.8	0.4	1.5	-0.3	0.7
Tense / ‘highly strung’	0.7	1.2	1.8	-1.3	1.1	-0.8	1.3	0.4	1.4	1.3	0.8	1.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.4	1.1	-0.8	1.1	-0.2	-0.1	0.1	-1.2	0.6	0.2
Hair/balding pattern: Pattern 4	0.9	2.2	4.1	1.7	-1.2	0.1	-2.0	-1.2	-1.7	-1.2	0.7	-2.0	-1.8
Birth weight of first child	0.3	0.6	1.9	1.3	0.0	1.4	0.3	0.8	0.8	-0.2	0.7	0.6	0.4
Peak expiratory flow (PEF)	0.2	0.5	2.0	-1.4	0.2	-0.2	-0.2	-0.4	-0.3	-1.1	-0.9	0.3	-0.7
Pulse wave reflection index	0.3	0.4	1.5	-0.6	0.4	0.5	-0.3	0.6	1.2	-0.7	0.5	0.5	0.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	-1.4	1.5	-0.4	1.2	0.4	0.4	0.9	-1.1	1.0	1.0
Loud music exposure frequency	1.3	1.5	3.8	-0.4	1.5	0.4	0.4	1.2	1.9	1.6	-0.1	1.5	1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	0.9	-0.5	0.7	-0.9	-0.1	-0.0	-1.1	1.3	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.1	-0.5	1.6	1.0	1.4	1.0	1.0	2.0	-1.1	1.7	0.9
Blood clot in the leg (DVT)	0.3	0.4	2.5	1.6	0.0	0.2	-0.2	0.2	-0.2	-0.1	0.7	-0.9	0.1
Medication: Paracetamol	0.2	0.3	2.0	-1.4	-0.6	0.1	0.1	-0.1	-0.5	-0.3	-0.3	0.0	-0.2
Headache pain in last month	1.6	2.7	8.2	-2.3	1.4	-0.7	1.8	0.4	0.8	2.9	-1.6	1.7	1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.4	1.4	1.2	0.2	1.1	1.1	1.6	0.4	1.3	1.0	1.4
Glaucoma (self-reported)	0.4	0.4	1.8	0.6	0.3	0.3	-0.3	0.6	0.5	0.5	1.4	-0.1	0.8
Gout (self-reported)	1.3	1.8	4.8	0.8	-2.2	0.4	-0.9	-0.7	-1.5	2.2	-0.4	-1.6	-1.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.8	-1.6	0.9	0.3	0.1	0.1	0.6	1.5	-1.7	1.0	-0.1
Medication: Amlodipine	0.5	0.7	1.4	0.3	-1.1	-0.8	-0.5	-1.0	-1.2	-0.1	-0.9	-0.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.5	0.0	0.0	0.7	0.3	0.5	-0.7	0.5	0.4	0.5
Birth weight	1.1	2.3	9.0	2.4	0.0	1.5	-0.5	1.5	1.2	-0.6	3.0	-0.5	1.3
Chronic bronchitis/emphysema (mother)	3.6	4.2	7.7	0.2	1.7	1.4	2.3	2.1	2.8	2.3	1.1	2.8	2.3
High blood pressure (siblings)	0.1	0.1	0.3	0.5	-0.2	-0.5	0.5	0.1	0.3	0.1	0.4	-0.1	0.5
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	-0.6	0.0	-0.1	0.0	-0.1	0.3	-0.3	-0.5	0.5	-0.1
Body fat percentage	0.2	0.9	1.7	-0.9	1.0	0.1	1.1	0.8	1.2	0.8	-0.9	1.3	1.0
Leg fat percentage (right)	0.3	0.9	1.3	-1.1	1.2	0.5	1.0	0.9	1.0	0.8	-1.0	1.1	0.9
Arm fat-free mass (right)	0.2	1.1	3.3	-0.9	1.8	1.1	-0.1	1.4	0.6	-1.4	-0.1	0.9	0.4
Exposure to tobacco smoke outside home	1.7	2.3	9.9	3.1	-0.7	-0.8	-1.8	-0.9	-0.3	-0.7	2.2	-1.5	-0.5
Comparative body size at age 10	0.2	0.6	2.0	0.3	-0.8	-1.1	0.5	-0.6	0.5	-0.5	-1.4	0.8	0.1
Number of full brothers	5.9	7.4	12.7	-1.0	2.4	3.2	2.9	3.6	3.0	2.9	0.5	2.9	3.2
Worry too long after embarrassment	0.2	0.3	1.0	-1.0	0.8	-0.3	0.5	-0.2	0.4	0.7	-0.2	0.5	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	-0.8	-0.2	-0.8	-0.6	-0.9	-0.5	0.4	-1.1	-0.3	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	1.3	0.0	-0.4	-0.5	-0.3	0.2	-1.2	0.9	-0.3	0.1
Number of children fathered	0.6	0.7	2.0	-0.5	1.0	0.8	0.3	1.1	0.8	1.4	0.2	0.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	5.2	2.3	0.0	0.4	-0.4	0.4	0.4	0.6	2.3	-0.6	0.5
Age at first live birth	0.7	1.2	3.1	-0.6	0.9	-1.1	1.8	0.2	1.2	0.5	-0.6	1.7	1.2
Pulse wave peak to peak time	0.3	0.4	1.5	0.2	-0.2	-0.6	0.5	-0.6	-0.6	1.2	-0.8	0.2	-0.4
Health satisfaction	0.2	0.2	0.4	-0.6	0.6	-0.4	0.7	0.3	0.4	-0.1	0.2	0.5	0.7
Shortness of breath walking on level ground	0.3	0.4	1.4	0.2	0.4	-0.3	0.8	0.6	0.8	-0.0	0.4	0.7	1.2
Qualifications: College or University degree	0.3	1.0	3.6	1.5	0.7	-0.2	0.3	0.6	1.4	-0.0	1.9	0.4	1.2
Eye problems/disorders: None of the above	0.8	0.9	3.8	-1.6	0.8	0.8	0.7	0.3	-0.7	0.7	-1.9	0.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.5	-0.4	0.1	0.2	0.2	0.1	-0.1	-0.3	0.7	0.1
Emphysema/chronic bronchitis	1.8	2.0	5.5	-0.1	1.4	0.8	1.8	1.4	2.4	1.0	0.9	1.4	1.6
Medication for pain relief, constipation, heartburn	0.6	0.9	2.4	0.9	0.9	0.7	0.8	0.7	1.4	1.6	-0.1	1.1	0.7
Neck or shoulder pain in last month	2.0	2.9	7.8	2.8	-1.6	-2.2	-1.1	-1.8	-1.3	-1.6	0.6	-1.9	-0.9
Medication: Blood pressure	0.2	0.4	0.9	-0.7	-0.9	-0.1	-0.6	-0.5	-0.4	0.0	-1.0	-0.4	-0.6
Angina (self-reported)	1.6	2.1	3.9	0.9	-0.7	-1.6	-1.7	-2.0	-1.6	-1.1	0.2	-1.8	-1.9
Migraine (self-reported)	3.1	3.8	10.8	-2.3	1.7	0.4	1.8	1.4	2.3	3.3	-0.2	2.0	2.1
Medication: Ibuprofen	0.4	0.5	1.1	0.0	-1.1	-0.2	-0.6	-0.4	-0.9	-1.0	-0.9	-0.8	-0.5
Medication: Allopurinol	1.0	1.3	4.8	1.4	-2.2	-0.4	-0.7	-0.8	-1.1	1.2	0.0	-1.5	-0.7
Medication: Omeprazole	1.6	1.9	3.9	-1.1	1.7	2.0	1.5	1.7	0.8	1.2	-1.0	1.3	0.9
Medication: Seretide 50 evohaler	1.0	1.1	6.5	2.5	0.1	0.4	-0.2	0.2	-0.1	-1.8	1.0	-0.7	0.2
Mean time to correctly identify matches	0.3	0.6	2.6	0.1	-0.2	-0.4	0.3	-0.6	-1.4	0.2	-1.6	-0.6	-0.4
Heart disease (mother)	0.8	1.0	3.4	0.0	1.8	-0.2	1.5	0.5	0.9	0.3	1.2	0.5	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	12.0	-1.7	-0.6	-0.9	0.4	-1.2	-1.1	0.7	-3.5	0.5	-1.2
Whole body fat mass	0.2	0.9	2.0	-1.2	1.1	0.2	0.8	0.9	1.1	0.1	-1.0	1.4	0.9
Leg fat mass (right)	0.4	1.5	2.6	-1.3	1.6	0.8	1.0	1.4	1.4	0.5	-1.0	1.6	1.2
Arm predicted mass (right)	0.2	1.0	2.9	-1.2	1.7	0.9	0.0	1.3	0.6	-1.4	-0.3	1.0	0.4
Pulse rate, automated reading	0.3	0.8	1.9	-0.5	1.2	-0.6	1.1	0.8	1.3	0.3	-0.0	1.0	1.4
Alcohol intake frequency.	0.5	1.2	5.4	-0.5	-0.1	-0.7	0.1	-1.1	-0.9	1.6	-2.3	0.4	-1.0
Comparative height size at age 10	0.1	0.4	2.0	-0.6	-0.1	0.1	0.4	0.5	0.5	-1.4	-0.3	0.8	0.3
Number of full sisters	1.2	1.5	6.6	1.4	-0.7	-0.4	-1.4	0.1	-0.5	-1.1	2.6	-1.5	0.4
Suffer from ‘nerves’	1.3	2.0	4.2	-1.9	2.0	0.4	1.7	1.2	1.2	1.5	-0.4	1.3	1.4
Overall health rating	0.4	0.8	2.1	-0.9	1.1	0.8	1.5	1.0	0.3	0.0	-1.0	0.7	0.8
Chest pain or discomfort	0.5	0.7	2.0	1.4	0.4	-0.1	-0.7	-0.2	-0.4	-1.4	1.1	-1.1	-0.3
Had major operations	1.1	1.3	4.4	2.1	0.9	1.5	0.6	1.3	0.2	0.2	1.6	-0.2	0.9
Age at last live birth	0.9	1.2	3.4	-1.4	-0.6	-1.9	1.2	-0.9	-0.1	0.0	-1.7	1.2	-0.0
Family relationship satisfaction	1.9	2.3	3.8	-0.4	2.0	1.3	1.8	1.8	1.5	1.1	-0.5	1.7	1.9
Leg pain on walking	0.4	0.5	2.7	-1.0	-0.7	-0.3	-0.4	-0.2	-0.1	-1.6	-0.1	-0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.0	-1.1	-0.0	-0.0	-1.0	-1.2	-1.2	-0.3	-1.7	-0.7	-1.7
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.3	-0.5	1.5	0.2	1.0	1.0	1.5	1.0	1.5	0.8	1.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.4	1.4	-1.0	1.0	-0.9	0.4	-0.3	-0.1	1.8	-1.5	-0.0
Medication: Aspirin	1.8	2.3	5.3	0.2	-0.8	-1.2	-1.6	-1.4	-2.0	-2.3	0.4	-2.2	-1.5
Supplements: Vitamin C	0.5	0.6	3.1	1.8	-0.1	-0.4	0.4	-0.4	-0.2	-1.4	0.5	-0.5	0.0
Knee pain experienced in last month	0.4	0.7	3.9	-1.0	-0.2	0.4	-0.3	0.0	-0.1	-0.9	-2.0	0.6	-0.6
Hypertension (Self-reported)	0.3	0.8	1.6	-0.2	-0.8	-0.5	-1.1	-1.1	-0.9	-0.7	-0.6	-1.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.5	-0.0	0.2	0.4	0.5	0.5	0.7	1.2	0.0	0.7	0.5
Illnesses of father: Heart disease	1.3	1.8	3.1	1.7	-1.2	-1.5	-1.7	-1.5	-0.9	-1.2	0.3	-1.6	-1.1
Illnesses of siblings: Diabetes	1.1	1.4	2.8	1.4	-0.9	-1.7	-1.4	-1.1	-0.8	-0.2	1.1	-1.6	-0.6
Smoking status: Previous	0.7	1.1	2.6	1.2	-0.8	-0.7	-1.4	-0.7	-0.6	-1.2	1.6	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	5.2	0.5	-0.8	-1.0	-1.1	-0.6	-0.3	-2.3	1.1	-0.4	-0.6
Whole body fat-free mass	0.1	0.8	3.5	-0.8	1.0	0.7	-0.6	1.0	0.4	-1.9	-0.0	0.7	0.0
Leg fat-free mass (right)	0.1	0.8	2.2	-1.0	1.2	0.6	-0.3	1.1	0.8	-1.5	-0.1	1.0	0.4
Arm fat percentage (left)	0.2	0.9	1.7	-1.1	0.8	-0.1	0.8	0.6	1.1	0.8	-1.3	1.3	0.8
Average weekly red wine intake	1.3	2.0	3.8	1.1	-1.5	-0.7	-1.6	-1.1	-1.3	-1.9	0.6	-1.9	-1.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	5.5	2.3	0.5	-0.2	0.4	0.2	0.3	-0.5	1.7	-0.6	0.5
Mood swings	2.1	3.8	7.2	-0.7	2.5	0.9	2.7	1.6	1.8	2.3	-1.1	2.6	2.1
Loneliness, isolation	1.9	2.6	5.5	-1.6	2.3	0.8	2.2	1.5	0.6	1.4	-1.7	1.7	1.6
Long-standing illness, disability or infirmity	0.3	0.5	2.0	1.4	0.4	0.7	0.6	0.9	0.3	-0.4	0.1	0.4	0.8
Ever had bowel cancer screening	0.1	0.1	0.7	-0.2	-0.3	0.2	0.7	-0.2	-0.2	-0.8	0.0	0.1	-0.2
Diabetes diagnosed by doctor	0.6	1.0	4.5	0.2	-0.5	-2.1	-0.5	-1.6	-0.5	-0.7	-0.9	-0.4	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.8	0.4	-0.7	-0.0	-0.4	-0.4	-0.8	1.1	-1.3	-0.4	-0.5
Friendships satisfaction	0.5	0.7	1.9	0.2	1.1	0.4	1.1	1.1	0.7	0.6	0.1	0.6	1.4
Qualifications: nursing, teaching	0.3	0.5	2.3	0.4	0.3	1.5	0.8	1.1	0.1	-0.1	0.2	0.7	0.6
Commuting to job workplace: Walk	1.1	1.2	3.6	1.9	-1.1	0.7	-1.7	-0.4	-0.8	-1.0	0.4	-1.2	-0.9
Eye problems/disorders: Cataract	1.0	1.2	2.4	1.5	-0.8	-0.9	-1.2	-0.8	-0.5	-1.2	1.5	-1.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.4	0.1	0.2	1.2	-1.1	-0.3	-1.5	-1.5	0.2	-1.4	-1.2
Medication for cholesterol	0.6	0.9	2.1	-0.6	0.3	1.4	1.1	1.2	0.8	1.0	-0.2	1.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	-0.3	0.9	-0.5	0.4	0.2	0.4	0.6	0.9	0.3	0.5
Back pain experienced in last month	2.0	3.0	8.3	1.6	-1.7	0.1	-2.0	-0.9	-1.8	-2.9	0.8	-2.2	-1.6
Mineral and other dietary supplements	1.3	1.7	4.0	-1.5	1.4	-0.1	1.5	0.7	1.7	1.2	-0.7	2.0	1.1
Breast cancer (self-reported)	4.1	4.9	18.4	-1.7	2.1	4.3	1.6	3.2	1.7	0.6	0.2	1.8	1.8
Asthma (self-reported)	0.1	0.3	0.7	0.8	0.6	0.6	0.3	0.5	0.4	-0.6	0.3	0.5	0.3
Osteoporosis (self-reported)	0.6	0.8	1.7	0.1	1.3	0.5	0.6	0.9	0.4	1.2	1.3	0.4	1.0
Osteoarthritis (self-reported)	1.3	1.7	5.8	1.3	-0.4	0.2	-1.2	-0.0	-0.6	-2.4	2.0	-1.9	-0.4
Medication: Aspirin	1.6	2.0	4.9	0.7	-0.8	-0.4	-1.6	-1.1	-1.8	-2.2	0.3	-2.2	-1.5
Medication: Gliclazide	0.3	0.3	0.7	0.5	-0.5	-0.4	-0.6	-0.7	-0.5	-0.7	-0.5	-0.6	-0.8
Illnesses of father: None of the above (group 1)	1.3	1.6	4.2	-2.0	1.5	1.5	1.1	1.1	0.2	1.5	-1.0	1.2	0.5
Smoking status: Current	0.4	0.7	1.2	-0.4	1.0	0.5	0.8	0.8	1.1	0.9	-0.5	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.8	-0.5	-0.6	-0.2	-0.4	-0.1	0.1	-0.6	-0.2	-0.1
Whole body water mass	0.1	0.8	3.3	-0.9	1.1	0.7	-0.5	1.0	0.4	-1.8	-0.2	0.8	0.1
Leg predicted mass (right)	0.1	0.8	2.1	-0.9	1.3	0.6	-0.3	1.1	0.8	-1.4	-0.1	1.0	0.5
Arm fat mass (left)	0.3	1.2	2.6	-1.6	1.1	0.2	0.8	0.9	1.2	0.2	-1.3	1.6	0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	0.8	0.2	0.0	-0.2	0.2	-0.2	0.1	0.4	-0.7	0.2
Average weekly champagne plus white wine intake	1.6	2.2	6.2	1.7	-1.1	-0.2	-2.5	-1.1	-1.3	-0.7	1.4	-2.1	-1.5
Miserableness	0.5	0.8	2.2	-0.1	1.2	-0.8	1.5	-0.4	0.0	0.7	-1.5	0.9	0.3
Guilty feelings	1.6	2.4	5.9	-1.3	1.6	-0.2	2.4	0.7	1.6	1.6	-1.2	2.3	1.4
Wears glasses or contact lenses	0.7	0.8	2.8	0.2	0.6	1.7	0.6	1.2	0.7	0.6	-0.4	1.2	0.7
Ever taken oral contraceptive pill	0.2	0.2	1.6	-0.4	1.3	-0.4	0.0	0.2	0.1	-0.6	-0.3	-0.1	0.2
Hearing aid user	0.3	0.4	2.3	0.6	-0.4	0.5	-0.2	0.3	0.4	1.5	0.4	0.3	0.3
Mother’s age at death	1.0	1.2	2.5	-1.0	0.9	1.6	1.3	1.5	0.9	0.8	-0.4	0.8	1.3
Financial situation satisfaction	0.2	0.2	1.0	0.3	0.0	1.0	-0.5	0.6	0.3	0.4	0.6	-0.1	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.5	-1.2	1.6	0.3	0.7	0.6	0.1	-0.5	-0.5	0.5	0.5
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.9	-0.0	-0.4	-0.6	-0.3	-0.6	-0.9	-0.1	-0.7	-0.1
Eye problems/disorders: Glaucoma	0.6	0.7	3.1	1.5	-0.0	-0.4	-0.9	-0.1	0.4	0.1	1.8	-0.7	0.3
Medication: Blood pressure	1.8	3.5	7.0	-0.0	-1.0	-1.5	-2.0	-2.2	-2.0	-2.6	-0.8	-2.4	-2.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.6	-0.5	-0.1	1.6	0.4	1.3	0.1	-1.1	0.5	0.6	0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.8	0.9	-1.6	-1.3	-1.2	-1.3	-1.6	-1.3	0.8	-1.9	-0.9
High cholesterol (Self-reported)	2.5	4.5	7.6	-0.8	-2.6	-2.3	-2.7	-2.4	-2.2	-1.4	0.6	-2.8	-2.1
Medication: Bendroflumethiazide	1.1	1.7	5.2	1.3	0.4	1.3	-1.4	-0.1	-0.8	-2.3	0.9	-1.8	-1.3
Medication: Paracetamol	0.2	0.3	1.1	-1.0	-0.5	-0.0	0.2	-0.1	-0.4	-0.2	-1.0	0.1	-0.2
Medication: Lisinopril	0.4	0.5	1.3	-0.6	-0.9	0.6	-1.1	-0.1	-0.6	-0.4	0.6	-0.9	-0.7
Medication: Atorvastatin	1.9	2.3	5.3	-1.1	-0.9	-2.1	-0.9	-2.3	-1.4	-1.1	-1.8	-0.5	-2.0
Illnesses of father: High blood pressure	0.5	0.6	2.6	1.6	-0.1	-0.5	0.4	-0.1	0.7	1.5	-0.2	0.5	0.6
Alcohol drinker status: Never	1.5	1.8	3.5	-0.4	-1.7	-1.0	-0.7	-1.8	-1.8	-0.9	-1.3	-1.1	-1.9
Ever smoked	0.5	0.8	3.1	0.5	1.1	0.4	0.0	0.9	1.2	-0.4	1.7	0.3	1.0
Basal metabolic rate	0.2	0.9	2.2	-1.2	1.3	0.7	-0.2	1.1	0.7	-1.5	-0.4	1.1	0.4
Leg fat percentage (left)	0.2	0.8	1.3	-1.0	1.0	0.5	0.8	1.0	1.1	0.8	-0.5	1.1	1.0
Arm fat-free mass (left)	0.2	0.9	2.2	-1.1	1.5	1.0	-0.1	1.3	0.7	-1.2	-0.1	1.1	0.5
Number of operations (self-reported)	1.4	2.0	5.0	2.0	2.0	2.2	0.9	1.9	0.4	-0.2	1.3	0.3	1.0
Average weekly beer plus cider intake	1.0	1.5	3.6	-1.2	-0.5	-1.3	-0.1	-1.4	-1.2	-1.7	-1.9	-0.2	-1.2
Irritability	3.3	5.6	9.1	0.3	2.4	2.3	2.6	3.0	3.0	2.0	0.9	2.5	3.0
Risk taking	0.6	0.9	3.0	0.2	1.6	0.8	0.4	0.9	0.6	1.7	-0.3	0.6	0.8
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.1	0.9	-0.0	1.0	-0.2	0.7	0.2	-0.4	1.4	-0.6	0.5
Fractured/broken bones in last 5 years	0.7	0.9	3.6	-0.7	1.1	1.9	0.5	1.1	0.9	0.8	0.4	1.0	0.1
Age started oral contraceptive pill	0.8	1.0	2.5	0.6	0.5	1.3	0.5	1.4	1.1	-0.8	1.6	0.4	1.0
Diastolic blood pressure, automated reading	0.5	1.6	2.6	1.5	-1.3	-1.3	-1.2	-1.3	-1.1	-1.6	-0.4	-1.4	-1.2
Ever depressed for a whole week	0.4	0.4	1.9	1.4	0.1	-0.3	-0.4	-0.3	-0.6	-1.0	0.5	-0.5	-0.3
Unable to work because of sickness or disability	1.7	2.3	4.1	-1.4	2.0	1.1	1.4	1.5	1.3	1.7	-1.1	1.8	1.3
Commuting to job workplace: Cycle	0.4	0.5	2.3	-0.3	0.3	1.5	0.9	0.7	0.1	0.0	-0.8	0.9	-0.1
Myopia	1.9	2.7	5.6	-1.5	-1.0	-1.6	-1.5	-2.2	-2.0	-1.1	-1.8	-0.7	-2.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.4	0.2	0.3	0.6	1.1	1.0	0.9	1.0	0.3	1.2	1.2
Cholesterol lowering medication	1.0	1.5	4.5	-0.7	-1.2	-2.1	-1.3	-1.4	-0.7	-0.5	1.2	-1.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	-0.5	1.6	1.6	1.1	1.2	0.7	1.0	-0.7	0.9	0.6
Pain experienced in last month	0.2	0.4	2.2	-1.5	0.6	-0.1	-0.1	-0.6	-0.1	0.6	-0.4	-0.0	-0.7
Supplements: Calcium	0.2	0.2	1.3	0.4	0.6	0.2	0.2	0.3	0.2	1.1	0.4	0.1	0.4
Basal cell carcinoma (self-reported)	1.3	1.5	2.4	-0.3	1.3	0.9	1.6	1.4	1.5	1.4	0.3	1.4	1.5
Heart attack/myocardial infarction (self-reported)	2.6	3.3	4.9	1.8	-1.8	-1.7	-1.2	-2.2	-2.0	-2.1	-0.7	-2.2	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.8	1.7	0.3	0.2	0.3	0.4	0.3	0.4	0.5	-0.3	0.4
Heart disease (siblings)	0.6	0.7	2.0	-1.3	1.1	0.2	0.6	-0.1	-1.0	0.7	-1.4	-0.1	-0.2
Alcohol drinker status: Previous	0.8	0.9	3.3	-1.2	1.8	1.0	0.3	0.3	-0.2	0.1	-1.7	0.5	-0.2
Pack years of smoking	1.4	2.1	4.5	-0.7	2.1	2.1	1.3	2.1	0.8	0.3	-0.5	1.2	1.7
Impedance of whole body	0.2	0.9	2.4	1.6	-1.5	-1.1	0.4	-0.9	-0.3	0.7	0.9	-0.7	-0.1
Leg fat mass (left)	0.3	1.2	2.1	-1.2	1.4	0.7	0.8	1.3	1.3	0.3	-0.6	1.4	1.2
Arm predicted mass (left)	0.2	0.9	1.8	-1.2	1.3	0.8	-0.0	1.2	0.8	-1.3	-0.1	1.1	0.4