Hub : Genes

PIK3IP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0240	1.1e-03	0.010	0.038	0.027	0.038	0.019	1.7e-02	1.6e-05	2.9e-04	1.9e-05	1.9e-03
2	GTEx	Adipose Subcutaneous	0.1570	0.0580	7.2e-05	0.067	NA	0.026	NA	0.034	3.8e-06	NA	2.9e-03	NA	7.7e-04
3	GTEx	Colon Transverse	0.1300	0.0620	2.6e-03	0.075	NA	0.012	NA	0.039	1.9e-04	NA	8.7e-02	NA	6.0e-03
4	GTEx	Nerve Tibial	0.0907	0.0328	1.4e-05	0.047	NA	0.094	NA	0.085	2.7e-04	NA	3.5e-07	NA	1.3e-06
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1530	0.0710	3.7e-03	0.006	NA	0.008	NA	0.010	1.5e-01	NA	1.1e-01	NA	8.7e-02
6	NTR	Blood	0.0257	0.0101	2.3e-06	0.014	0.019	0.017	0.017	0.018	1.2e-05	7.4e-07	2.9e-06	2.1e-06	8.9e-07
7	YFS	Blood	0.1434	0.0285	0.0e+00	0.208	0.193	0.211	0.209	0.208	3.2e-66	8.4e-61	5.6e-67	2.5e-66	4.2e-66

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	3.3	5.3	10.2	-2.1	1.7	1.0	2.5	2.1	-2.8	-3.2
Bipolar Disorder or Schizophrenia	3.3	8.2	21.3	-2.7	2.4	0.2	2.3	3.0	-2.9	-4.6
Depressed Affect (Nagel 2018)	0.7	1.5	2.8	1.7	0.4	1.6	1.6	1.1	-1.3	-0.4
Depression (Nagel 2018)	0.8	1.2	2.6	0.5	0.8	1.1	1.6	0.5	-1.5	-1.1
Intelligence (Savage-Jansen 2018)	1.5	4.5	9.3	2.7	0.4	-1.5	-1.1	-2.4	2.4	3.1
Neuroticism (Nagel 2018)	0.5	1.1	2.9	1.6	-0.3	1.1	0.5	-0.8	0.1	1.7
Schizophrenia (2018)	1.8	3.7	11.2	-1.9	1.6	-0.5	0.9	2.2	-1.5	-3.4
Schizophrenia vs Biploar Disorder	3.0	3.9	6.2	1.0	-1.3	-2.0	-2.4	-1.8	2.5	2.4
Worry (Nagel 2018)	0.3	0.7	2.1	0.7	-0.6	0.7	0.3	-1.1	0.1	1.4
Alzheimer’s Disease (in mother)	2.6	3.1	5.0	1.0	-1.0	-1.5	-1.7	-2.2	2.1	2.2
Alzheimer’s Disease (in father)	1.7	1.8	5.1	-2.3	-1.0	-1.0	-1.8	-1.1	1.0	-0.1
Alzheimer’s Disease (including proxy)	1.7	2.4	4.6	-0.4	-0.9	-1.4	-1.7	-2.1	2.0	1.6
Crohns Disease (2017)	0.2	0.3	1.6	1.3	0.4	0.3	-0.0	0.6	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.8	1.9	3.7	1.9	1.5	1.9	1.3	1.0	-1.0	0.5
Ulcerative Colitis (UC)	1.6	3.1	7.1	1.6	2.1	2.7	2.0	1.0	-1.1	1.2
Major Depression (MDD)	0.2	0.2	0.9	0.9	0.2	0.0	0.2	0.4	-0.1	-0.5
Reaction Time	3.6	6.9	22.5	-4.7	0.2	-1.1	-0.1	2.0	-1.7	-4.2
Verbal and Numeric Reasoning (VNR)	1.7	4.1	12.3	3.2	0.0	-0.7	-0.6	-1.6	1.6	3.5
Breast Cancer	0.3	0.7	1.3	-0.6	-0.5	-0.8	-0.9	-1.1	1.1	0.8
Ovarian Cancer	0.2	0.3	0.9	0.6	0.7	-0.9	0.3	-0.1	-0.1	0.2
Prostate Cancer	0.6	0.8	1.6	-0.4	-1.2	-1.2	-0.7	-0.7	0.8	-1.1
Age at First Birth	4.3	6.2	10.0	-0.1	-1.8	-3.2	-3.1	-2.8	2.9	2.1
Bipolar Disorder (2011)	1.5	1.5	2.2	-0.7	1.2	0.5	1.5	1.5	-1.2	-1.4
Body Mass Index (BMI) (2010)	0.7	0.9	2.5	-1.6	-0.8	-1.0	-0.5	0.4	0.1	-1.4
Coronary Artery Disease (CAD)	0.8	1.0	4.1	0.0	-1.3	-0.4	-0.1	0.7	-0.7	-2.0
Crohns Disease (2012)	0.4	0.7	2.4	1.5	0.8	0.7	0.5	0.6	-0.6	0.3
Mean Putamen Volume	0.6	0.7	2.2	-0.9	0.9	0.5	0.9	1.5	-0.5	-0.3
Fasting Glucose	0.9	1.1	5.1	0.8	0.1	-0.3	-0.1	-1.2	0.8	2.3
HbA1C	0.6	0.7	1.4	1.2	-0.8	0.7	-0.3	-0.7	0.5	1.1
HDL Cholesterol	0.8	1.3	3.6	1.9	-0.7	-0.4	-1.2	-0.3	1.1	1.5
LDL Cholesterol	1.2	1.9	3.0	0.4	1.5	1.6	1.7	1.5	-1.3	-1.3
Lupus	0.5	0.7	3.2	-1.8	-0.4	-0.1	-1.1	0.1	0.8	-0.1
Neuroticism (2016)	1.3	1.9	4.0	0.9	-0.9	0.2	-1.3	-1.8	1.7	2.0
Primary Biliary Cirrhosis	1.1	1.6	3.6	1.7	-0.8	-0.6	-1.2	-0.7	1.2	1.9
Rheumatoid Arthritis	0.3	0.4	1.0	-1.0	-0.9	0.5	-0.5	0.5	0.2	0.3
Schizophrenia (2014)	1.2	2.7	10.3	-1.9	0.7	-1.2	0.3	1.2	-1.2	-3.2
Triglycerides	0.1	0.2	0.9	1.0	0.0	-0.3	0.6	-0.4	0.2	0.0
Type 2 Diabetes (T2D) (2012)	1.8	2.1	3.0	1.7	-0.9	-1.3	-1.6	-1.2	1.7	1.5
Ulcerative Colitis	2.4	3.5	5.8	1.4	2.2	2.4	2.1	1.9	-2.0	0.2
Blood Eosinophil Count	3.4	26.4	56.7	-6.9	-2.8	-4.7	-7.5	-3.7	5.5	-2.5
Blood Platelet Count	0.1	1.6	6.4	-1.9	0.6	0.5	-0.5	-0.6	0.6	2.5
Blood Red Count	0.3	2.6	6.2	0.5	1.4	1.7	1.9	1.2	-1.5	2.5
Blood White Count	2.6	19.4	29.7	4.4	4.5	5.5	5.3	3.1	-3.7	3.9
Heel T-Score	0.6	4.8	18.8	-2.5	-0.8	-1.5	-0.1	1.6	-1.7	-4.3
BMI	0.3	1.7	6.9	-1.5	-0.3	-0.2	-0.6	1.3	-0.8	-2.6
Height	0.5	9.9	16.9	-1.5	-4.1	-4.0	-3.6	-4.0	2.0	1.4
Waist Hip Ratio (WHR)	2.8	12.6	29.0	4.2	-1.7	-1.8	-1.4	-4.9	3.1	5.4
Systolic Blood Pressure	0.9	4.6	15.2	3.9	2.3	2.2	1.6	-0.3	0.2	2.1
Smoking Status	0.8	2.0	7.1	2.7	-1.1	-0.3	-0.7	-1.6	1.0	1.3
Allergy or Eczema	2.2	5.8	10.7	-0.9	-2.6	-3.3	-3.3	-1.9	1.8	2.2
Cardiovascular Disease	0.2	0.7	2.3	1.5	-0.2	-0.3	-0.6	-1.0	1.0	0.1
Hypothyroidism (self reported)	0.6	1.5	7.1	-0.9	0.3	1.2	0.3	0.8	-0.6	-2.7
Respiratory disease	1.4	3.1	7.5	-0.6	-2.1	-2.7	-2.4	-1.2	1.4	0.5
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.5	1.3	0.1	-2.1	-0.7	-1.5	1.6	1.8
Lung FEV1/FVC ratio	0.2	1.0	2.6	-0.1	-0.5	-1.6	-0.3	-0.9	1.2	-1.5
Lung FVC	1.2	6.0	13.4	-3.7	-2.4	-2.8	-3.1	-0.3	1.1	-2.1
Neuroticism	0.7	1.8	4.5	1.8	-0.9	0.7	-0.1	-1.8	0.6	2.1
Chronotype (morning person)	1.5	3.4	7.8	-0.6	0.5	0.9	1.4	2.4	-2.6	-2.8
Hair Pigment	0.3	8.0	25.7	2.9	-1.7	-1.4	-1.7	-2.6	2.6	5.1
Tanning	0.4	4.3	10.4	-0.8	2.1	0.9	2.1	2.6	-3.2	-1.7
Hand grip strength (left)	1.0	2.7	7.4	-2.7	-1.4	-1.7	-2.0	-0.8	0.9	-1.0
Number of treatments/medications taken	2.5	4.5	10.3	0.2	-3.2	-2.1	-2.4	-2.5	2.1	0.4
Average weekly spirits intake	0.5	0.6	1.7	-0.1	0.3	1.2	0.9	0.4	-1.3	-0.0
Sensitivity / hurt feelings	0.7	1.1	3.0	0.3	-1.0	0.5	-0.4	-1.7	0.8	1.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.5	-0.7	-0.6	-0.5	-0.9	-0.4	-0.1
Hearing difficulty/problems: Yes	3.3	5.0	8.8	2.8	-1.5	-1.5	-2.0	-2.2	2.3	3.0
Relative age of first facial hair	1.9	3.8	6.1	-0.2	-2.5	-2.4	-2.1	-2.0	2.1	1.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.8	0.4	-1.4	-0.5	-0.6	-2.2	1.1	0.5
Ever used hormone-replacement therapy (HRT)	2.0	2.6	6.0	0.8	-2.4	-1.5	-1.8	-1.8	1.5	0.8
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-0.6	-0.2	0.1	-0.7	0.2	0.9	-1.1
Systolic blood pressure, automated reading	1.1	3.1	7.1	2.7	2.3	2.1	1.8	0.9	-0.5	1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.0	1.0	0.2	0.1	-0.2	-0.2	0.7	1.0
Angina	0.2	0.2	1.3	0.2	0.1	-0.2	0.1	0.2	-0.2	-1.2
Medication for hormone replacement therapy	3.0	3.3	8.0	-0.1	-2.1	-2.1	-2.8	-1.6	1.9	0.0
Vitamin and mineral supplements	0.7	0.9	3.5	0.6	1.9	0.9	1.1	0.6	-0.7	-0.2
Supplements: Zinc	0.1	0.2	0.5	0.1	0.3	0.4	0.7	0.3	-0.6	0.1
Medication: Co-codamol	0.9	1.1	2.7	1.0	-0.8	-1.0	-0.6	-1.6	0.8	1.1
Medication: Metformin	1.2	1.7	3.8	1.9	1.9	0.6	1.9	0.6	-0.7	0.4
Diabetes (father)	1.0	1.2	5.9	2.4	-0.2	-0.5	-0.6	-0.6	0.4	1.3
Diabetes (mother)	0.9	1.2	2.3	-1.1	0.9	0.5	0.9	1.5	-1.1	-1.4
Severe depression (siblings)	3.2	3.5	10.1	-0.7	-2.0	-1.4	-3.2	-1.0	2.5	-1.1
Pack years adult smoking proportion	1.8	2.7	7.3	0.6	2.7	1.5	2.0	1.6	-1.2	-1.1
Impedance of leg (right)	1.2	5.8	19.0	3.8	0.6	0.3	1.0	-2.1	1.1	4.4
Leg fat-free mass (left)	0.4	2.3	5.4	-2.3	-1.7	-0.4	-1.5	0.1	-0.6	-2.1
Trunk fat percentage	0.4	1.5	2.9	1.5	0.8	1.7	1.5	0.0	-0.9	1.2
Hand grip strength (right)	1.4	3.7	9.2	-3.0	-1.3	-2.4	-2.1	-1.4	1.0	-1.3
Townsend deprivation index at recruitment	0.7	1.0	3.3	0.6	0.9	1.8	1.1	0.9	-0.9	-0.3
Current tobacco smoking	1.9	3.1	12.8	3.6	0.2	0.6	0.3	-1.3	1.0	2.4
Average weekly fortified wine intake	0.5	0.5	1.1	1.1	0.6	0.6	0.8	-0.2	-0.3	1.0
Maternal smoking around birth	0.4	0.6	2.7	1.6	0.1	-0.5	-0.2	-0.5	0.7	0.7
Fed-up feelings	0.8	1.4	6.2	-0.8	-0.0	0.7	0.2	1.1	-1.1	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.1	-0.4	0.3	0.6	1.2	0.8	-1.8	-1.4
Relative age voice broke	1.0	1.5	2.1	-1.4	-1.2	-1.4	-1.4	-0.9	1.0	1.3
Taking other prescription medications	4.0	6.2	9.7	0.8	-2.7	-2.5	-2.7	-3.1	2.9	2.0
Age when periods started (menarche)	1.6	3.9	14.7	1.8	1.0	1.8	1.9	-0.0	-1.0	3.8
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	6.2	1.0	-0.9	-0.9	-1.7	-1.9	2.5	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	9.1	-1.3	-1.6	-1.9	-1.2	1.3	-0.4	-3.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-0.5	1.0	0.9	-0.3	-0.5	0.7	0.3
Qualifications: CSEs or equivalent	1.0	1.3	5.2	-2.3	0.2	0.2	0.5	0.6	-1.0	-1.5
Serious illness, injury or assault to yourself	3.4	4.2	6.3	2.2	1.3	2.5	2.3	2.5	-2.0	-0.7
High blood pressure	0.5	1.4	5.0	2.2	0.6	0.7	0.4	-1.0	0.6	1.6
Hayfever, allergic rhinitis or eczema	2.0	4.3	7.0	-0.7	-1.7	-2.5	-2.7	-2.2	1.8	2.3
Multivitamins +/- minerals	0.2	0.2	1.0	-0.6	-1.0	-0.3	-0.3	-0.1	0.3	-0.1
Stomach or abdominal pain in last month	0.5	0.7	2.1	1.5	0.4	-0.6	0.1	-0.7	0.4	1.1
Supplements: Glucosamine	1.0	1.4	4.1	0.2	-2.0	-1.6	-1.5	-0.0	0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.7	-1.0	1.4	1.0	1.2	1.6	-1.2	-0.6
Medication: Atenolol	0.1	0.2	0.5	0.7	0.5	-0.1	0.3	-0.7	0.1	-0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.1	-0.1	0.3	0.1	-0.4	0.1	-0.3
Sitting height	0.3	2.1	7.4	-2.7	-1.6	-0.0	-1.1	-0.4	-0.6	-1.7
Chronic bronchitis/emphysema (father)	0.6	0.7	3.1	0.9	-1.8	-0.6	-0.6	-0.2	0.6	0.3
High blood pressure (mother)	0.9	1.3	6.3	2.5	1.0	0.1	0.7	0.3	-0.4	0.9
Body mass index (BMI)	0.3	1.4	6.4	-0.8	-0.3	0.1	-0.2	1.2	-0.9	-2.5
Impedance of leg (left)	1.4	6.6	20.8	4.1	1.4	0.9	1.6	-1.7	0.7	4.6
Leg predicted mass (left)	0.4	2.4	5.5	-2.3	-1.8	-0.5	-1.6	0.1	-0.6	-2.1
Trunk fat mass	0.1	0.5	1.3	0.7	0.1	1.1	0.8	-0.2	-0.8	0.5
Waist circumference	0.1	0.5	1.2	1.1	-1.0	-0.1	-0.3	-1.1	0.1	0.5
Number of incorrect matches in round	0.1	0.1	0.3	0.5	-0.3	0.5	-0.1	-0.2	0.2	-0.2
Past tobacco smoking	0.3	0.5	2.0	0.0	0.9	-0.6	0.0	0.2	0.3	1.4
Alcohol usually taken with meals	1.6	2.6	8.7	-1.1	1.1	0.4	1.7	1.4	-1.4	-2.9
Nervous feelings	0.5	0.9	2.1	-0.8	-0.8	0.1	-0.9	-1.4	0.8	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.2	-0.1	-0.4	0.5	-0.5	-0.6	-0.6
Hearing difficulty/problems with background noise	2.2	3.6	4.8	1.6	-2.1	-1.2	-1.9	-2.2	2.0	2.1
Hair/balding pattern: Pattern 2	1.4	1.8	5.0	2.2	-1.1	-0.7	-0.6	-1.2	1.3	1.6
Had menopause	0.0	0.0	0.1	0.0	0.3	-0.2	0.2	-0.3	0.2	-0.1
Had other major operations	4.3	5.2	12.9	-2.3	1.0	0.6	2.0	2.7	-2.3	-3.6
Forced vital capacity (FVC)	2.2	8.3	14.9	-3.9	-3.2	-3.8	-3.5	-1.7	1.3	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.6	-0.8	-1.8	-1.2	-0.9	0.8	-0.4	-2.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.3	-1.3	1.2	0.6	1.6	1.1	-1.8	-1.6
Qualifications: None of the above	0.4	0.9	2.5	0.6	-1.6	-0.3	-0.6	-1.2	1.2	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.0	-0.1	0.6	-0.2	-0.6	-0.1	-0.4
Mouth/teeth dental problems	0.6	0.9	3.5	1.0	1.0	0.4	0.5	0.2	-0.4	1.9
Heart attack	0.1	0.1	0.4	0.2	-0.5	-0.3	-0.0	0.4	-0.3	-0.6
Allergy	1.8	4.2	6.3	0.2	2.0	2.4	2.5	2.0	-1.8	-2.5
Pain all over the body in last month	2.5	2.7	6.4	1.8	-1.0	-0.7	-1.0	-2.2	1.5	2.5
Diabetes (self-reported)	0.5	0.8	2.2	1.1	1.5	-0.2	1.2	-0.5	0.2	0.9
Hayfever/allergic rhinitis (self-reported)	1.9	2.6	4.6	1.0	-1.6	-1.8	-2.1	-1.9	1.8	0.4
Medication: Ramipril	0.2	0.3	0.7	0.6	-0.8	-0.4	-0.9	-0.4	0.0	-0.2
Medication: Simvastatin	0.9	1.4	2.4	1.1	-1.2	-1.4	-0.6	-1.5	1.4	0.5
Fluid intelligence score	0.4	0.8	2.8	1.3	0.3	-0.7	-0.1	-0.7	0.6	1.7
Illnesses of siblings	1.1	1.5	4.0	-2.0	0.5	1.1	0.6	1.2	-1.1	-1.5
Neuroticism score	0.2	0.4	0.8	0.5	-0.7	0.9	-0.1	-0.7	-0.1	0.7
Weight	0.2	1.0	2.6	-1.3	-1.3	-0.4	-0.9	-0.1	-0.6	-1.6
Impedance of arm (right)	1.4	6.5	18.8	2.7	2.3	2.8	2.6	-0.1	-0.4	4.3
Arm fat percentage (right)	0.3	1.1	1.9	0.5	1.0	1.4	1.2	1.1	-1.1	-0.9
Trunk fat-free mass	0.8	4.4	8.1	-2.8	-2.7	-1.7	-2.3	-0.5	-0.2	-2.7
Hip circumference	0.5	2.0	4.5	-1.0	-0.0	1.2	0.8	1.6	-2.0	-2.1
Time employed in main current job	0.8	0.9	1.5	-0.8	-1.2	-1.2	-1.2	-0.7	0.9	0.1
Alcohol intake versus 10 years previously	1.2	1.8	5.8	-2.1	-0.8	-0.9	-0.5	0.9	-0.5	-2.4
Father’s age at death	6.3	8.5	17.4	0.3	3.8	3.5	4.2	2.5	-3.0	0.5
Worrier / anxious feelings	0.2	0.4	1.4	-1.2	0.1	0.3	0.1	0.6	-0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.0	1.4	0.0	0.5	-0.1	-0.4	-0.5	-0.1
Falls in the last year	1.1	1.5	3.5	-0.3	1.3	0.8	1.7	0.9	-1.9	-0.6
Hair/balding pattern: Pattern 3	0.9	1.3	2.3	1.5	1.4	1.5	0.9	-0.2	0.2	1.2
Number of live births	1.7	2.3	8.4	-1.6	0.2	0.2	1.0	1.0	-1.8	-2.9
Forced expiratory volume in 1-second (FEV1)	2.4	8.2	17.0	-3.7	-2.8	-4.1	-3.0	-1.7	1.2	-2.4
Pulse rate	0.2	0.3	0.6	-0.4	-0.8	-0.6	-0.5	-0.7	0.5	0.2
Happiness	1.2	1.4	3.5	-1.4	0.7	0.2	1.0	1.1	-1.9	-1.4
Noisy workplace	1.7	2.1	4.6	-0.9	-1.4	-1.6	-1.6	-1.0	1.2	-2.1
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.0	0.4	2.2	0.9	1.8	1.1	-1.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.6	1.3	1.2	0.2	0.7	0.1	-0.4	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.7	-0.5	-1.1	-0.5	-0.2	-0.1	0.3	-1.3
Asthma	1.3	2.7	7.3	-0.5	-1.8	-2.7	-2.1	-1.0	1.3	1.0
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	5.8	-0.7	1.1	2.0	1.0	2.4	-2.1	-2.4
Medication: Cholesterol lowering	0.2	0.4	1.8	-0.4	-0.6	-0.4	-0.0	-0.3	0.3	-1.3
Depression (self-reported)	1.1	1.3	2.4	0.4	-0.6	-1.5	-0.9	-1.5	1.1	1.3
Medication: Lansoprazole	2.2	2.5	8.7	1.1	-0.6	-1.2	-0.6	-2.1	1.1	3.0
Prospective memory result	0.2	0.3	0.9	0.9	-0.0	0.8	0.3	0.1	-0.2	0.5
Lung cancer (father)	0.6	0.7	2.2	1.5	-0.1	1.0	1.0	0.1	-0.8	0.1
Illnesses of mother	0.7	0.8	4.3	-2.1	-0.2	-0.4	-0.0	-0.5	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	13.4	-3.7	-1.9	-3.0	-2.2	-1.1	0.7	-2.3
Pulse wave Arterial Stiffness index	1.9	2.2	4.5	1.3	-2.1	-0.5	-1.4	-1.0	1.4	2.1
Impedance of arm (left)	1.4	6.6	20.3	2.5	2.4	2.6	2.6	-0.7	-0.1	4.5
Arm fat mass (right)	0.1	0.3	1.4	-0.4	-0.2	0.4	0.0	0.4	-0.7	-1.2
Trunk predicted mass	0.8	4.4	7.9	-2.8	-2.6	-1.6	-2.3	-0.5	-0.2	-2.7
Standing height	0.4	3.7	8.9	-1.3	-2.6	-1.3	-1.8	-3.0	0.9	1.7
Length of working week for main job	1.5	1.7	5.5	-0.3	0.7	0.5	0.5	2.4	-1.6	-1.6
Exposure to tobacco smoke at home	1.6	1.8	3.2	-1.6	0.6	0.8	1.4	1.2	-1.8	-1.6
Breastfed as a baby	3.1	3.9	5.8	-1.2	-2.4	-1.9	-2.4	-2.0	1.9	1.7
Tense / ‘highly strung’	0.4	0.6	1.6	1.2	-0.4	0.3	-0.2	-1.3	0.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.9	1.7	-1.2	0.0	-0.9	-1.1	1.0	0.7
Hair/balding pattern: Pattern 4	0.4	0.9	3.8	-0.0	-1.9	-0.6	-1.3	0.2	0.2	-0.0
Birth weight of first child	3.3	6.1	11.1	-3.0	-3.0	-3.3	-2.6	-1.1	1.2	-2.1
Peak expiratory flow (PEF)	2.6	5.9	16.5	-2.2	-2.2	-4.1	-2.6	-1.7	1.5	-1.8
Pulse wave reflection index	0.5	0.6	1.7	1.1	-0.7	-0.2	-0.5	-0.4	0.5	1.3
Ever highly irritable/argumentative for 2 days	1.7	2.0	5.9	-0.2	-2.4	-1.8	-1.6	-1.3	0.9	0.3
Loud music exposure frequency	0.3	0.4	1.5	-0.2	-0.1	0.4	0.4	0.7	-0.5	-1.2
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.4	1.5	2.1	1.6	1.8	1.4	-1.5	0.8
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.5	-1.9	1.6	1.1	1.1	1.3	-1.3	-1.7
Blood clot in the leg (DVT)	0.6	0.7	1.5	-1.2	-0.8	-0.7	-1.1	-0.3	0.5	-1.0
Medication: Paracetamol	0.6	1.0	3.2	-0.6	-1.2	-1.1	-0.6	0.3	-0.0	-1.8
Headache pain in last month	1.2	2.1	3.1	-1.5	1.4	0.7	1.5	1.3	-1.8	-1.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	-1.2	-0.1	-0.4	-0.5	0.5	0.1	0.2
Glaucoma (self-reported)	1.3	1.5	7.1	2.7	-0.1	0.1	0.1	-0.9	0.6	1.5
Gout (self-reported)	0.6	0.8	1.8	1.0	-0.4	-1.0	-0.5	-1.0	0.6	1.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.9	-1.3	-0.8	0.3	-0.3	-0.4	0.1	-2.0
Medication: Amlodipine	0.5	0.8	1.7	0.7	-0.8	-0.8	-1.0	-1.3	0.8	0.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.1	-0.9	-1.7	-1.8	-1.4	-0.9	1.2	1.5
Birth weight	1.2	2.5	4.3	-1.4	-1.4	-2.0	-2.1	-1.2	1.8	-0.6
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.9	1.1	-0.1	1.7	0.6	1.5	-0.9	-0.5
High blood pressure (siblings)	0.4	0.6	1.2	1.0	-0.2	-0.9	-0.9	-0.4	1.1	0.7
Forced vital capacity (FVC), Best measure	1.8	6.6	18.2	-4.3	-2.6	-2.9	-2.8	-1.4	1.0	-1.3
Body fat percentage	0.3	1.0	2.0	1.4	0.7	1.3	1.3	0.3	-0.8	0.5
Leg fat percentage (right)	0.1	0.5	2.4	1.5	0.3	0.4	0.7	0.1	-0.4	-0.0
Arm fat-free mass (right)	0.7	3.8	7.0	-2.1	-2.6	-1.8	-2.3	-1.0	0.2	-2.2
Exposure to tobacco smoke outside home	4.7	6.2	10.2	-1.6	1.9	2.1	2.5	3.1	-3.2	-2.6
Comparative body size at age 10	0.9	2.4	9.3	-1.0	1.0	0.3	1.0	1.8	-1.1	-3.0
Number of full brothers	0.8	1.1	2.2	-1.4	0.2	-0.8	1.2	0.1	-1.0	-1.5
Worry too long after embarrassment	0.4	0.7	1.5	0.1	-0.6	0.6	-0.9	-1.2	0.7	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.5	1.2	-0.4	-0.7	-0.5	-1.0	1.1	1.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.3	0.2	0.6	0.5	1.1	1.0	-1.5	0.2
Number of children fathered	0.4	0.4	1.0	0.6	-0.7	1.0	0.2	-0.1	0.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.2	0.6	-0.2	0.3	-0.6	0.2	0.1
Age at first live birth	0.1	0.2	0.9	-0.9	0.2	-0.1	-0.5	-0.2	-0.1	0.4
Pulse wave peak to peak time	2.3	2.7	5.7	-1.5	2.1	0.6	1.5	1.2	-1.6	-2.4
Health satisfaction	1.1	1.5	4.7	-1.1	0.5	0.8	0.7	1.1	-1.4	-2.2
Shortness of breath walking on level ground	0.4	0.5	2.2	0.5	0.7	1.5	-0.1	-0.1	0.1	0.6
Qualifications: College or University degree	0.6	1.9	3.3	-1.1	1.6	1.2	1.2	1.5	-1.8	-1.1
Eye problems/disorders: None of the above	0.6	0.6	2.4	-1.6	0.7	0.0	0.4	0.3	-0.9	-0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	5.0	-0.3	0.3	0.1	1.1	0.5	-1.0	-2.2
Emphysema/chronic bronchitis	0.5	0.6	3.2	1.8	-0.2	0.2	0.7	-0.3	-0.2	0.6
Medication for pain relief, constipation, heartburn	1.2	2.1	8.2	1.1	1.5	1.4	1.0	0.0	0.0	2.9
Neck or shoulder pain in last month	1.9	2.7	5.6	-0.2	0.8	1.7	1.6	2.4	-2.2	-1.5
Medication: Blood pressure	0.8	1.3	4.3	2.1	0.9	1.5	1.1	-0.3	-0.7	0.3
Angina (self-reported)	0.1	0.2	0.9	0.5	0.1	-0.2	0.1	0.1	0.0	-0.9
Migraine (self-reported)	0.9	1.1	2.1	-0.1	-1.4	-1.4	-1.1	-1.5	0.8	0.2
Medication: Ibuprofen	1.6	1.9	4.1	-0.3	0.6	1.5	0.5	1.8	-1.7	-2.0
Medication: Allopurinol	0.8	1.0	4.3	2.1	-0.1	-0.4	-0.1	-0.9	0.7	1.3
Medication: Omeprazole	3.6	4.3	6.9	-0.1	-2.5	-2.6	-2.4	-2.5	2.0	0.9
Medication: Seretide 50 evohaler	1.6	1.8	3.5	1.7	-1.4	-1.9	-1.5	-0.7	0.8	1.0
Mean time to correctly identify matches	3.0	5.7	18.9	-4.3	0.4	-1.2	-0.0	1.7	-1.6	-3.8
Heart disease (mother)	0.7	0.9	2.1	-0.5	0.6	0.5	0.6	1.2	-1.1	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.9	-0.2	1.4	1.7	1.3	1.1	-1.1	-1.0
Whole body fat mass	0.0	0.2	0.4	0.5	-0.2	0.6	0.3	-0.0	-0.6	-0.1
Leg fat mass (right)	0.0	0.1	0.4	0.3	-0.2	0.2	0.1	0.2	-0.5	-0.7
Arm predicted mass (right)	0.7	3.4	7.2	-1.8	-2.7	-1.8	-2.3	-1.2	0.2	-1.8
Pulse rate, automated reading	1.1	3.6	7.4	2.4	-1.5	-1.0	-1.1	-1.6	2.2	2.7
Alcohol intake frequency.	0.4	1.0	4.9	-1.3	-0.0	-0.6	0.0	0.7	-0.1	-2.2
Comparative height size at age 10	0.7	3.9	9.2	-1.0	-2.5	-1.7	-2.2	-3.0	1.6	0.9
Number of full sisters	1.1	1.3	3.4	-1.2	0.9	-0.1	1.1	1.4	-0.8	-1.8
Suffer from ‘nerves’	0.9	1.4	4.7	1.2	-0.5	1.0	-0.4	-1.4	0.7	2.2
Overall health rating	0.6	1.3	3.6	1.2	-1.9	-0.5	-1.5	-0.7	1.1	-0.0
Chest pain or discomfort	0.2	0.3	1.0	0.9	-0.3	0.1	0.5	0.1	-0.1	-1.0
Had major operations	3.7	4.3	8.3	0.9	-2.7	-1.5	-2.2	-2.9	2.4	1.1
Age at last live birth	0.4	0.5	1.9	-1.4	0.7	0.3	0.4	0.4	-0.7	-0.6
Family relationship satisfaction	0.4	0.5	1.1	-0.5	-1.1	-1.0	-0.6	-0.7	0.5	-0.0
Leg pain on walking	0.4	0.5	1.1	1.0	0.9	0.1	0.9	0.0	-1.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.4	0.5	-0.3	0.4	0.8	-0.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.0	-0.3	-0.3	-0.8	-0.6	0.7	-0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.3	-0.7	-0.5	-1.5	-0.7	-0.5	0.7	0.3
Medication: Aspirin	0.2	0.3	0.8	-0.9	0.3	-0.4	0.5	-0.5	-0.5	-0.6
Supplements: Vitamin C	0.8	0.9	2.4	-1.1	0.0	0.1	0.9	1.0	-1.1	-1.5
Knee pain experienced in last month	0.3	0.5	1.5	1.2	-0.9	0.2	0.1	-0.4	0.4	0.8
Hypertension (Self-reported)	0.5	1.5	5.5	2.3	0.8	0.8	0.6	-0.8	0.5	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	0.1	-0.6	-1.7	-0.4	-0.9	0.3	0.9
Illnesses of father: Heart disease	1.7	2.4	4.5	-1.2	-1.9	-1.9	-2.1	-0.9	1.6	-0.1
Illnesses of siblings: Diabetes	1.1	1.4	3.1	1.8	-1.1	-1.7	-0.8	-0.4	0.9	0.6
Smoking status: Previous	0.5	0.7	2.7	-0.6	-0.5	0.7	0.3	0.6	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.1	-1.1	-2.0	-0.6	-1.5	-0.9	0.1	-0.5
Whole body fat-free mass	0.6	3.6	6.9	-2.6	-2.4	-1.2	-2.1	-0.2	-0.3	-2.6
Leg fat-free mass (right)	0.4	2.2	5.6	-2.4	-1.5	-0.1	-1.3	0.4	-0.8	-2.2
Arm fat percentage (left)	0.2	0.8	1.4	0.6	1.0	1.2	1.1	0.7	-0.9	-0.5
Average weekly red wine intake	1.1	1.6	4.7	0.6	1.9	0.7	2.2	0.2	-1.4	-0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	0.1	0.4	-0.4	-0.4	0.2	0.1	0.7
Mood swings	0.4	0.7	1.7	-0.9	-0.3	1.1	0.7	0.6	-1.3	-0.6
Loneliness, isolation	0.2	0.3	0.9	0.9	0.5	0.4	0.4	0.5	-0.3	-0.3
Long-standing illness, disability or infirmity	3.1	4.8	11.0	1.9	-2.2	-1.7	-1.8	-3.3	2.0	2.1
Ever had bowel cancer screening	1.2	1.4	4.1	1.7	0.9	0.6	0.9	-0.9	0.6	2.0
Diabetes diagnosed by doctor	0.4	0.6	1.6	1.3	0.9	-0.4	0.9	-0.3	0.3	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	-0.9	0.8	0.4	1.1	0.4	-0.7	-1.0
Friendships satisfaction	0.5	0.7	2.6	-1.6	-0.1	0.4	0.2	0.1	-0.2	-1.3
Qualifications: nursing, teaching	0.6	1.0	2.5	-0.0	1.5	1.6	0.4	1.1	-0.8	0.4
Commuting to job workplace: Walk	1.3	1.4	8.5	2.9	0.2	-0.1	0.6	-0.1	-0.2	1.0
Eye problems/disorders: Cataract	0.8	0.9	3.2	0.3	1.1	1.8	1.1	0.8	-0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	3.5	1.7	-1.5	-1.4	-1.4	-1.7	1.9	0.8
Medication for cholesterol	0.3	0.4	1.0	-0.6	0.5	1.0	0.7	0.5	-0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	1.0	-0.9	0.1	0.1	0.2	-0.0	-0.3
Back pain experienced in last month	0.1	0.2	0.4	0.4	0.1	-0.4	0.5	-0.6	-0.1	-0.7
Mineral and other dietary supplements	0.4	0.5	1.7	0.0	1.3	-0.3	0.3	-0.2	-0.0	1.3
Breast cancer (self-reported)	1.8	2.1	3.4	1.3	1.6	1.6	1.8	1.8	-1.1	-0.4
Asthma (self-reported)	1.5	3.0	8.2	-0.9	-2.0	-2.9	-2.3	-1.0	1.2	0.5
Osteoporosis (self-reported)	1.2	1.5	3.5	1.6	1.2	1.1	1.9	0.5	-1.2	-0.3
Osteoarthritis (self-reported)	0.4	0.6	0.9	0.5	-1.0	-0.8	-0.7	-1.0	0.8	0.4
Medication: Aspirin	0.2	0.2	0.6	-0.8	-0.2	-0.3	0.4	-0.5	-0.4	-0.5
Medication: Gliclazide	4.1	4.7	12.2	0.9	3.5	2.1	3.0	1.6	-1.9	-0.2
Illnesses of father: None of the above (group 1)	2.7	3.4	7.1	-0.8	2.2	2.7	2.4	1.1	-1.8	-0.9
Smoking status: Current	1.6	2.5	9.3	3.1	-0.1	0.2	-0.1	-1.5	1.0	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	4.6	-2.1	-0.2	-1.2	-0.5	-0.1	-0.1	-1.9
Whole body water mass	0.6	3.7	7.0	-2.6	-2.4	-1.2	-2.2	-0.2	-0.3	-2.6
Leg predicted mass (right)	0.4	2.2	5.8	-2.4	-1.4	-0.1	-1.2	0.4	-0.9	-2.2
Arm fat mass (left)	0.1	0.3	1.6	-0.4	-0.2	0.3	-0.1	0.3	-0.6	-1.3
Number of self-reported non-cancer illnesses	3.7	6.4	11.8	0.0	-2.6	-3.0	-2.9	-3.4	2.9	0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.7	-0.3	0.1	0.2	0.4	0.2	-0.8	-0.7
Miserableness	1.5	2.7	4.8	-0.2	1.4	1.7	1.8	1.9	-2.2	-1.4
Guilty feelings	0.6	1.0	2.1	-1.4	-0.9	-0.6	-0.8	-1.4	0.5	0.9
Wears glasses or contact lenses	0.2	0.2	0.7	0.1	0.3	-0.0	0.9	-0.7	-0.0	0.5
Ever taken oral contraceptive pill	0.2	0.2	0.9	-1.0	-0.1	-0.7	-0.4	-0.0	-0.1	-0.4
Hearing aid user	1.0	1.1	2.0	0.8	-1.1	-1.2	-1.4	-0.7	1.3	-0.0
Mother’s age at death	3.6	4.4	6.8	-2.0	2.0	1.7	2.1	2.6	-2.3	-1.9
Financial situation satisfaction	2.5	3.0	7.0	-0.4	1.4	1.8	2.6	1.4	-2.6	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.9	-0.3	0.3	0.2	0.9	-0.6	-0.6
Commuting to job workplace: Public transport	0.7	0.8	2.1	0.1	0.8	1.5	0.8	-0.4	-0.2	1.4
Eye problems/disorders: Glaucoma	0.8	1.0	3.4	1.9	-0.4	-0.2	-0.3	-1.1	1.1	0.8
Medication: Blood pressure	0.5	0.9	2.2	0.4	-0.4	-1.5	-0.9	-1.0	1.2	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.9	0.2	-0.1	0.8	-0.5	-0.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	0.6	-0.5	1.5	0.3	-0.0	0.3	-0.6
High cholesterol (Self-reported)	0.4	0.8	2.9	0.0	1.0	-0.2	0.9	0.4	-0.8	-1.7
Medication: Bendroflumethiazide	0.5	0.8	2.7	1.7	-0.2	0.2	-0.0	-0.4	0.5	1.5
Medication: Paracetamol	0.4	0.6	1.4	-0.1	-1.2	-0.9	-0.6	0.1	0.3	-1.2
Medication: Lisinopril	0.5	0.7	2.5	1.6	0.9	0.3	0.6	0.1	-0.1	1.0
Medication: Atorvastatin	1.5	1.9	5.3	-0.7	1.1	0.7	1.6	0.9	-1.5	-2.3
Illnesses of father: High blood pressure	0.6	0.8	2.3	0.5	0.3	0.7	0.8	1.5	-1.1	-0.7
Alcohol drinker status: Never	1.7	2.0	5.3	-0.4	2.3	1.0	1.9	1.4	-1.2	-0.6
Ever smoked	0.2	0.3	1.1	-0.3	-0.4	0.8	0.2	-0.1	-0.5	-1.1
Basal metabolic rate	0.5	3.0	6.1	-2.4	-2.1	-0.9	-1.9	-0.1	-0.5	-2.5
Leg fat percentage (left)	0.3	1.0	2.9	1.7	0.9	0.9	1.2	0.5	-0.8	0.0
Arm fat-free mass (left)	0.8	4.1	7.5	-2.4	-2.6	-1.7	-2.4	-0.4	-0.1	-2.7
Number of operations (self-reported)	0.5	0.7	2.0	-0.1	-0.6	-1.4	-0.3	-0.5	0.7	-1.3
Average weekly beer plus cider intake	0.7	0.9	4.6	0.6	-0.9	0.5	-0.4	-0.7	0.1	2.1
Irritability	0.7	1.2	4.5	2.1	-0.5	0.7	0.1	-1.6	0.5	0.9
Risk taking	0.4	0.5	1.2	0.7	0.4	0.8	1.1	0.4	-1.0	0.2
Ever had prostate specific antigen (PSA) test	3.3	3.8	7.9	2.0	-0.2	0.2	-0.9	-2.6	2.6	2.8
Fractured/broken bones in last 5 years	0.4	0.5	1.0	1.0	-0.6	-0.2	-0.9	-0.7	1.0	0.2
Age started oral contraceptive pill	0.2	0.3	1.2	-1.1	0.6	0.0	0.1	0.1	0.6	-0.2
Diastolic blood pressure, automated reading	0.6	1.8	8.8	3.0	0.3	1.1	0.5	-0.3	0.5	1.3
Ever depressed for a whole week	0.9	1.1	2.1	-0.8	-1.3	-1.3	-1.0	-1.4	0.7	-0.3
Unable to work because of sickness or disability	1.6	2.1	3.6	1.1	-1.4	-1.3	-1.7	-1.9	1.7	0.7
Commuting to job workplace: Cycle	0.7	0.9	2.3	-1.3	0.5	-0.3	0.7	0.8	-1.5	-0.8
Myopia	0.4	0.5	1.1	1.0	0.6	0.8	0.0	0.7	-0.1	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.5	5.7	-2.4	-0.5	-0.8	-0.4	0.9	-0.4	-1.7
Cholesterol lowering medication	0.2	0.3	1.1	0.4	-0.5	-0.7	0.5	0.2	-0.3	-1.0
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	6.7	0.2	-1.7	-2.6	-1.7	-2.0	1.6	1.0
Pain experienced in last month	0.3	0.5	1.4	0.2	0.0	-0.5	-0.8	-0.6	0.9	1.2
Supplements: Calcium	1.1	1.3	3.1	0.3	-1.8	-1.3	-1.2	-1.0	1.0	0.7
Basal cell carcinoma (self-reported)	0.9	1.0	2.3	-0.7	-1.4	-1.5	-0.9	-0.6	0.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.1	-0.7	-0.7	-0.3	0.1	-0.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.6	-1.3	-0.7	-0.9	-1.2	-0.2	0.6	-1.1
Heart disease (siblings)	0.1	0.1	0.3	0.1	0.5	0.3	0.5	-0.5	0.2	0.0
Alcohol drinker status: Previous	0.4	0.5	1.3	1.1	0.3	0.5	1.1	-0.0	-0.5	-0.4
Pack years of smoking	1.8	2.6	7.3	0.9	2.7	1.5	2.1	1.3	-1.1	-0.8
Impedance of whole body	1.3	6.7	21.5	3.3	2.0	2.0	2.4	-1.0	0.2	4.6
Leg fat mass (left)	0.0	0.2	0.4	0.4	-0.1	0.4	0.1	0.2	-0.5	-0.6
Arm predicted mass (left)	0.7	3.6	7.7	-2.3	-2.4	-1.5	-2.0	-0.2	-0.2	-2.8