Hub : Genes

UBXN11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2640	0.0480	0.0e+00	0.240	0.209	0.248	0.243	0.256	7.2e-29	5.3e-25	6.5e-30	2.7e-29	6.3e-31
2	GTEx	Nerve Tibial	0.1584	0.0599	1.8e-04	-0.004	NA	0.018	NA	0.002	8.2e-01	NA	1.8e-02	NA	2.1e-01
3	GTEx	Spleen	0.2930	0.1070	3.5e-03	0.097	NA	0.037	NA	-0.009	1.8e-03	NA	4.1e-02	NA	6.5e-01
4	GTEx	Testis	0.3250	0.0720	1.7e-09	0.304	NA	0.277	NA	0.290	5.2e-14	NA	1.0e-12	NA	2.6e-13
5	METSIM	Adipose	0.0558	0.0209	2.9e-05	0.012	0.027	0.022	0.026	0.014	5.0e-03	5.7e-05	2.4e-04	7.1e-05	3.0e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.3030	0.0526	0.0e+00	0.252	0.244	0.243	0.239	0.259	3.3e-32	4.9e-31	6.3e-31	2.1e-30	3.4e-33
7	TCGA	Brain Lower Grade Glioma	0.0468	0.0249	1.7e-04	0.020	0.028	0.025	NA	0.023	2.1e-03	3.5e-04	6.5e-04	NA	1.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.3	2.1	8.1	0.2	-2.8	1.9	0.4	-0.1	1.2	-1.3
Bipolar Disorder or Schizophrenia	0.9	2.1	6.9	-0.4	-2.2	2.6	0.7	-0.1	0.7	-1.4
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	1.3	-1.2	1.5	-0.7	0.7	-0.5	-0.5
Depression (Nagel 2018)	0.4	0.6	1.5	1.1	-0.3	0.4	-1.2	1.1	-0.5	0.1
Intelligence (Savage-Jansen 2018)	0.7	2.0	5.3	-2.3	0.1	-0.9	-1.5	2.0	-0.7	1.1
Neuroticism (Nagel 2018)	0.4	1.0	2.7	1.6	0.1	1.5	-0.9	0.8	-0.3	-0.6
Schizophrenia (2018)	0.3	0.7	3.4	-0.6	-0.5	1.8	0.6	-0.1	-0.1	-0.7
Schizophrenia vs Biploar Disorder	0.8	1.0	4.7	-0.1	2.2	-1.1	0.1	-0.6	-0.8	0.7
Worry (Nagel 2018)	0.3	0.7	1.5	1.0	0.5	0.8	-1.2	1.1	-0.3	-0.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.3	0.9	-0.2	0.6	-1.1	-0.3	0.4	-0.5
Alzheimer’s Disease (in father)	0.6	0.6	2.0	-1.1	0.4	-1.4	-0.8	0.3	0.0	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	0.1	-0.3	0.5	-1.0	-0.6	0.6	-0.6
Crohns Disease (2017)	1.1	2.4	12.1	-0.5	3.5	-1.5	-0.9	-0.2	-0.7	1.0
Irritable Bowel Disease (IBD)	2.4	5.7	13.6	-0.9	3.7	-1.9	-2.6	2.0	-2.5	2.3
Ulcerative Colitis (UC)	2.4	4.5	7.2	-0.3	2.0	-1.0	-2.6	2.7	-2.7	2.2
Major Depression (MDD)	1.1	1.4	3.3	0.4	-1.4	1.8	0.4	-0.3	1.4	-1.3
Reaction Time	0.9	1.7	3.9	0.9	-0.6	0.2	1.7	-2.0	1.6	-1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	7.9	-2.8	0.3	0.0	-1.4	1.3	0.2	0.3
Breast Cancer	0.7	1.6	3.4	-0.0	-1.6	0.3	1.2	-1.7	1.8	-1.0
Ovarian Cancer	1.0	1.3	2.6	-0.4	0.9	-1.2	-1.1	0.8	-1.4	1.6
Prostate Cancer	0.7	0.9	2.6	-0.6	0.7	-0.3	-1.4	1.6	-0.7	0.5
Age at First Birth	1.0	1.5	4.0	-1.3	1.3	-0.3	1.6	-2.0	0.3	0.1
Bipolar Disorder (2011)	0.8	0.8	2.5	-0.3	-0.8	0.5	-0.9	1.6	-1.1	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	3.0	-0.7	1.7	-0.2	0.5	-0.9	-0.4	0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.6	-0.8	-0.3	-0.3	0.4	0.5	-0.3	0.7
Crohns Disease (2012)	0.4	0.6	2.1	-0.2	1.4	-0.8	-0.9	-0.3	-0.5	0.3
Mean Putamen Volume	1.2	1.4	2.6	-1.3	1.5	-1.2	-0.7	0.8	-1.0	1.6
Fasting Glucose	0.6	0.7	2.6	0.8	-0.4	0.2	1.6	-0.3	1.0	-0.8
HbA1C	2.1	2.3	7.1	0.0	-2.0	2.7	0.0	0.3	1.1	-1.9
HDL Cholesterol	1.6	2.7	4.2	1.4	-2.0	0.9	1.7	-1.3	1.9	-2.0
LDL Cholesterol	0.4	0.7	1.9	0.2	-0.2	0.1	-1.2	1.4	-1.1	0.4
Lupus	0.8	1.1	3.7	0.7	-1.0	0.5	1.9	-1.5	0.2	-0.5
Neuroticism (2016)	0.5	0.7	1.9	0.9	0.0	1.4	-0.2	1.0	0.2	-0.9
Primary Biliary Cirrhosis	0.7	1.0	2.4	0.8	-0.9	-0.4	-0.9	1.6	-1.2	0.8
Rheumatoid Arthritis	0.2	0.2	1.0	1.0	-0.2	0.5	-0.3	0.2	0.0	-0.6
Schizophrenia (2014)	0.2	0.4	1.3	0.3	-0.1	1.1	0.8	-0.4	-0.4	-0.6
Triglycerides	1.4	2.3	5.3	-2.0	1.4	0.2	-1.0	1.1	-2.3	1.6
Type 2 Diabetes (T2D) (2012)	1.9	2.2	8.7	2.9	-1.5	1.2	-0.0	0.9	0.4	-1.3
Ulcerative Colitis	1.7	2.5	6.6	0.6	0.8	0.0	-2.0	2.6	-2.2	1.1
Blood Eosinophil Count	1.9	14.7	36.6	-2.9	2.2	-0.8	-6.0	4.7	-4.4	3.4
Blood Platelet Count	1.2	13.5	44.4	-3.8	2.3	1.5	-4.6	6.7	-2.2	1.4
Blood Red Count	0.5	4.5	17.1	0.6	-2.6	1.0	-2.3	4.1	-0.8	0.4
Blood White Count	0.2	1.5	3.3	1.8	1.6	1.5	0.2	0.4	0.4	-1.4
Heel T-Score	1.1	8.4	24.0	4.9	-2.4	0.2	-2.4	4.5	0.3	-1.6
BMI	0.2	1.4	4.1	-0.6	1.1	0.7	2.0	-1.2	1.1	-0.9
Height	0.5	9.3	27.7	-0.3	1.4	-5.3	2.9	-3.3	4.0	-0.1
Waist Hip Ratio (WHR)	1.0	4.5	12.5	2.7	-2.7	1.6	-0.6	3.5	-0.3	-1.1
Systolic Blood Pressure	0.2	1.1	2.0	-1.3	1.4	1.2	-1.3	-0.2	-0.8	0.5
Smoking Status	0.9	2.2	6.9	1.9	-2.6	1.5	0.8	0.3	0.8	-1.2
Allergy or Eczema	3.7	9.8	14.5	-3.4	2.7	-2.9	-3.4	1.8	-3.3	3.8
Cardiovascular Disease	0.1	0.3	1.1	-0.4	0.2	-0.0	-1.1	0.1	-0.7	0.6
Hypothyroidism (self reported)	0.6	1.3	2.9	0.5	-1.1	1.7	1.5	-0.6	1.0	-1.0
Respiratory disease	2.0	4.4	10.5	-3.2	2.2	-0.2	-2.7	-0.1	-1.9	2.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.5	0.4	-2.1	1.4	-1.3	1.9	-1.0	-0.5
Lung FEV1/FVC ratio	0.1	0.5	1.0	0.3	1.0	-1.0	0.6	-0.9	0.5	-0.3
Lung FVC	0.5	2.7	6.4	-2.5	2.0	-0.9	1.2	-2.2	1.2	0.5
Neuroticism	0.3	0.7	1.7	1.3	0.4	1.2	-0.5	0.7	0.1	-0.7
Chronotype (morning person)	0.3	0.8	2.7	1.7	-1.3	0.1	-0.6	-0.2	-0.4	-0.8
Hair Pigment	0.1	1.7	4.5	1.1	-1.9	2.1	0.0	0.0	0.8	-1.5
Tanning	0.0	0.5	2.0	0.7	-1.4	0.7	-0.3	0.5	-0.7	-0.2
Hand grip strength (left)	0.4	1.0	2.1	-0.6	1.1	-0.8	1.0	-1.2	1.4	-0.2
Number of treatments/medications taken	0.9	1.7	3.2	1.8	-0.6	1.2	1.0	-0.9	1.3	-1.7
Average weekly spirits intake	0.4	0.5	1.4	0.1	-0.6	0.9	0.3	-0.2	1.2	-0.8
Sensitivity / hurt feelings	0.6	1.0	2.2	1.3	0.6	1.5	-0.6	1.1	-0.0	-0.9
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.2	2.1	-0.9	1.7	-1.1	1.6	-0.5	-0.6
Hearing difficulty/problems: Yes	1.3	2.0	8.5	2.9	-1.4	1.1	0.4	0.8	0.3	-1.2
Relative age of first facial hair	0.6	1.2	3.8	0.1	0.3	-0.9	-1.9	1.4	-1.0	0.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	4.2	2.0	-0.1	1.3	1.1	-0.8	1.5	-2.0
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.7	1.6	-1.5	0.5	-0.9	1.4	0.1	-0.5
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	1.1	0.0	1.4	0.1	1.4	-0.2	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.8	-1.3	1.1	0.9	0.3	-1.1	0.3	-0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.5	0.9	-2.1	1.7	0.4	-0.0	0.5	-1.1
Angina	0.5	0.6	2.1	1.4	-1.1	0.6	-0.2	-0.0	-0.7	-0.4
Medication for hormone replacement therapy	0.9	1.1	4.9	2.2	-1.4	-0.6	0.2	0.3	0.1	-0.3
Vitamin and mineral supplements	1.0	1.3	8.5	0.2	-2.9	0.6	-0.1	0.4	0.4	-0.4
Supplements: Zinc	0.8	0.9	3.8	2.0	-1.1	-0.0	0.8	-0.5	0.1	-0.4
Medication: Co-codamol	0.6	0.7	1.8	-0.7	0.3	0.1	0.9	-1.2	1.4	-0.3
Medication: Metformin	0.9	1.3	2.9	0.8	-1.7	0.8	-1.0	1.7	-0.6	-0.5
Diabetes (father)	2.9	3.6	10.1	1.9	-3.2	2.3	-0.0	0.5	1.2	-2.2
Diabetes (mother)	0.9	1.2	4.2	0.8	-1.1	1.0	-0.8	2.1	-0.7	-0.3
Severe depression (siblings)	0.6	0.6	1.4	1.1	0.2	0.3	-1.2	1.2	-0.6	0.1
Pack years adult smoking proportion	0.6	0.9	2.9	1.4	-1.7	0.2	0.6	0.3	0.6	-1.0
Impedance of leg (right)	0.8	4.0	15.1	-0.7	-0.8	-0.4	-2.3	3.9	-2.0	1.6
Leg fat-free mass (left)	1.2	6.1	19.4	0.5	0.7	-0.8	3.0	-4.4	3.2	-1.6
Trunk fat percentage	0.7	2.8	4.7	1.8	-1.6	1.6	1.6	-0.3	2.0	-2.2
Hand grip strength (right)	0.5	1.3	2.2	-0.4	1.2	-1.3	1.3	-1.5	1.3	0.3
Townsend deprivation index at recruitment	1.1	1.5	5.7	0.7	-0.6	-0.6	-1.3	2.4	-1.2	0.6
Current tobacco smoking	2.7	4.5	9.4	3.1	-2.4	2.5	1.5	0.5	1.4	-2.5
Average weekly fortified wine intake	0.6	0.7	2.1	-1.4	0.6	0.3	0.2	-0.6	1.2	-0.5
Maternal smoking around birth	1.2	1.7	6.2	1.1	-2.5	1.7	-0.7	0.1	0.3	-1.0
Fed-up feelings	1.2	2.2	7.2	2.7	-1.4	2.2	0.2	0.2	-0.0	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	0.7	0.2	0.8	0.0	0.1	-0.4	-0.1
Relative age voice broke	0.4	0.5	1.8	1.3	-0.7	-0.6	-0.7	0.7	-0.4	-0.0
Taking other prescription medications	0.4	0.6	1.7	0.8	0.4	1.3	1.0	-0.6	0.5	-0.8
Age when periods started (menarche)	0.4	0.9	1.8	-0.8	1.0	-1.3	1.4	-0.6	0.0	0.8
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	5.2	2.3	-1.0	2.0	0.2	1.2	0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.3	1.8	-1.2	0.3	-0.7	1.7	0.5	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.0	-0.7	0.5	-0.8	-0.8	1.4	-0.3	0.5
Qualifications: CSEs or equivalent	0.4	0.5	2.0	-0.3	-0.9	1.4	-0.3	-0.3	-0.1	-0.6
Serious illness, injury or assault to yourself	0.3	0.4	1.8	1.3	-0.0	-0.2	-0.6	-0.7	-0.4	0.3
High blood pressure	0.4	1.2	2.9	-0.2	-1.3	1.7	-0.2	-0.3	1.3	-1.5
Hayfever, allergic rhinitis or eczema	4.5	9.8	18.0	-3.4	2.8	-2.0	-4.2	2.4	-3.2	3.3
Multivitamins +/- minerals	1.1	1.4	8.0	-0.2	2.8	-0.9	-0.4	0.1	-0.8	0.6
Stomach or abdominal pain in last month	0.8	1.0	2.1	0.8	0.5	1.0	1.5	-0.7	1.0	-1.3
Supplements: Glucosamine	1.3	1.7	6.3	-1.3	2.5	-1.0	0.4	-0.1	-1.2	1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.9	-1.0	0.6	-0.1	0.3	0.4	-0.7
Medication: Atenolol	0.2	0.2	0.7	0.0	-0.9	-0.0	0.6	-0.5	-0.1	-0.1
Medication: Levothyroxine sodium	2.1	3.5	4.8	1.5	-2.2	1.7	2.1	-1.4	1.9	-2.2
Sitting height	1.2	8.5	19.4	-0.7	2.0	-4.4	2.9	-4.3	2.7	0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.6	0.3	1.0	-0.9	0.9	0.2	-0.4
High blood pressure (mother)	0.1	0.1	0.3	-0.3	0.6	-0.4	-0.4	-0.0	-0.2	0.3
Body mass index (BMI)	0.5	1.9	3.1	0.5	-0.5	1.7	1.5	-1.5	1.6	-1.8
Impedance of leg (left)	0.7	3.3	14.2	-0.2	-1.0	0.2	-2.1	3.8	-1.7	1.0
Leg predicted mass (left)	1.1	6.0	19.1	0.5	0.7	-0.9	3.0	-4.4	3.1	-1.6
Trunk fat mass	0.7	3.0	6.1	1.4	-0.9	1.0	2.1	-1.4	2.5	-2.2
Waist circumference	0.6	2.3	4.2	1.6	-1.4	1.7	1.4	-0.4	1.5	-2.1
Number of incorrect matches in round	0.5	0.8	2.0	-0.5	-0.4	0.6	1.1	-1.4	1.2	-0.6
Past tobacco smoking	0.5	1.0	3.9	0.4	2.0	-1.3	0.3	-1.1	0.3	-0.0
Alcohol usually taken with meals	1.7	2.7	7.5	-0.8	1.7	-1.8	1.9	-2.7	0.9	0.5
Nervous feelings	0.2	0.4	1.2	1.1	0.3	0.8	-0.5	0.6	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.8	1.2	0.7	-0.3	-0.8	1.3	-1.0	0.5
Hearing difficulty/problems with background noise	1.0	1.7	4.0	2.0	-2.0	1.3	0.6	-0.1	0.2	-1.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	-0.0	1.5	-0.7	-1.0	0.3	-1.1	1.1
Had menopause	0.6	0.7	1.9	-0.6	0.2	-1.4	-0.8	0.6	-1.0	1.0
Had other major operations	0.7	0.9	3.0	0.6	-1.7	0.8	1.1	-1.0	0.0	-0.5
Forced vital capacity (FVC)	0.9	3.4	9.2	-0.8	1.3	-1.1	2.3	-3.0	2.4	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.3	1.1	-0.3	0.3	-0.9	1.5	0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	6.6	2.6	-2.1	1.7	0.7	0.2	0.5	-1.6
Qualifications: None of the above	0.1	0.1	0.4	-0.0	-0.0	-0.1	0.4	0.6	-0.1	-0.5
Financial difficulties in last 2 years	0.4	0.6	1.4	1.2	0.7	-1.0	0.1	-0.8	-0.5	0.4
Mouth/teeth dental problems	0.2	0.2	0.9	0.2	0.4	0.5	0.1	-1.0	0.4	-0.4
Heart attack	0.6	0.7	1.3	-0.2	-0.6	-0.9	-1.1	0.7	-1.0	1.1
Allergy	3.2	7.4	16.8	3.8	-2.6	0.4	4.1	-1.6	2.4	-2.4
Pain all over the body in last month	0.2	0.3	0.6	-0.4	0.2	-0.7	0.4	-0.1	-0.7	0.8
Diabetes (self-reported)	0.8	1.2	2.9	0.9	-1.7	0.5	-1.4	1.0	-0.9	-0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.1	-2.3	1.2	-1.6	-1.1	-0.0	-0.4	1.2
Medication: Ramipril	1.1	1.5	3.8	1.0	0.6	-0.8	-1.4	0.8	-1.9	1.3
Medication: Simvastatin	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1	0.2	-0.1	-0.1
Fluid intelligence score	0.6	1.2	3.5	-1.2	-0.6	0.5	-1.9	1.7	0.0	0.1
Illnesses of siblings	0.5	0.8	2.0	1.0	-1.4	-0.4	-0.7	0.6	-0.9	0.5
Neuroticism score	1.0	2.1	5.9	2.0	-0.3	2.4	-0.9	1.3	-0.1	-1.3
Weight	0.7	3.7	8.1	0.6	0.0	0.1	2.5	-2.9	2.8	-1.8
Impedance of arm (right)	0.5	2.2	6.6	1.8	-2.6	1.0	-0.4	2.0	-0.4	-0.5
Arm fat percentage (right)	0.9	3.5	6.8	1.4	-1.6	2.6	1.7	-0.8	1.9	-2.5
Trunk fat-free mass	1.0	6.0	18.7	-0.7	2.0	-1.8	2.6	-4.3	2.9	-0.8
Hip circumference	0.8	3.5	7.2	0.8	-0.6	0.8	2.5	-2.7	2.4	-1.9
Time employed in main current job	2.6	3.0	4.8	1.3	-2.1	1.3	1.8	-1.0	2.1	-2.2
Alcohol intake versus 10 years previously	0.7	1.1	3.3	0.9	-1.2	0.7	-0.7	1.8	0.5	-0.9
Father’s age at death	1.0	1.4	7.7	0.9	-0.0	-2.8	-0.2	-0.2	-0.1	1.0
Worrier / anxious feelings	0.3	0.5	1.8	0.5	0.6	1.4	0.1	-0.7	0.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.6	1.6	-1.5	1.2	-1.3	1.9	-0.4	-0.5
Falls in the last year	0.4	0.5	1.8	1.0	-1.4	-0.3	0.1	0.4	0.5	-0.6
Hair/balding pattern: Pattern 3	0.6	1.0	1.8	-0.8	-1.3	0.5	1.2	-0.8	1.1	-0.9
Number of live births	0.9	1.3	3.7	0.4	-1.9	1.9	0.3	1.0	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	7.6	-0.3	1.8	-1.0	2.0	-2.7	2.3	-0.7
Pulse rate	1.4	2.4	6.1	1.6	-2.5	-0.4	-1.3	2.2	-0.9	0.6
Happiness	0.4	0.5	1.4	1.1	0.3	-0.2	-0.9	0.3	-1.2	0.4
Noisy workplace	0.8	0.9	4.8	2.2	-0.6	0.1	0.9	0.6	-0.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.7	-0.7	0.1	-0.3	0.2	-1.3	0.6	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	0.7	1.3	0.4	-1.3	0.6	-0.8	0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	3.0	-0.7	0.3	-0.7	-0.2	1.7	-0.3	0.6
Asthma	2.8	5.5	12.9	-3.6	2.3	0.7	-3.6	0.5	-1.9	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.5	0.3	0.2	-0.7	0.4	-0.3	-0.5	0.4
Medication: Cholesterol lowering	0.4	0.7	1.3	0.2	-0.7	0.6	1.0	-1.1	0.6	-1.0
Depression (self-reported)	0.7	0.8	1.6	1.3	-1.0	0.9	1.0	-0.7	0.7	-0.6
Medication: Lansoprazole	0.2	0.2	1.1	1.0	0.3	0.2	0.3	0.0	0.3	-0.5
Prospective memory result	0.5	0.6	1.7	-1.3	1.2	-0.6	-0.8	-0.1	-0.4	0.6
Lung cancer (father)	0.4	0.5	1.6	0.7	0.5	0.3	-0.5	0.7	-1.2	0.3
Illnesses of mother	0.2	0.3	1.5	0.2	1.2	0.3	0.4	-0.5	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	10.6	-1.0	1.9	-1.3	2.5	-3.3	2.3	-0.3
Pulse wave Arterial Stiffness index	1.7	2.0	4.0	2.0	-0.1	-1.0	-1.9	2.0	-1.1	0.6
Impedance of arm (left)	0.4	1.8	4.9	1.8	-2.2	0.6	-0.3	1.8	-0.4	-0.4
Arm fat mass (right)	0.9	3.7	6.2	1.2	-0.7	1.9	2.2	-2.0	2.5	-2.5
Trunk predicted mass	1.0	6.0	18.9	-0.7	2.0	-1.8	2.6	-4.3	2.8	-0.8
Standing height	0.6	5.6	11.8	0.3	1.2	-3.4	2.6	-3.2	2.9	-0.2
Length of working week for main job	1.3	1.4	7.7	-2.8	1.1	-0.2	-0.9	0.0	-0.1	0.6
Exposure to tobacco smoke at home	1.7	1.9	4.6	1.7	-0.1	-1.1	-1.3	1.4	-2.1	0.9
Breastfed as a baby	2.3	2.9	6.4	2.1	-0.4	0.5	2.5	-1.9	1.8	-1.4
Tense / ‘highly strung’	0.3	0.6	1.1	0.7	-0.3	1.0	-1.0	1.0	-0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.4	1.6	0.7	-0.1	-0.2	-0.4	0.4	-0.6
Hair/balding pattern: Pattern 4	2.0	4.9	13.7	3.7	-2.4	2.6	1.3	0.3	0.6	-2.5
Birth weight of first child	0.2	0.3	1.0	0.1	1.0	0.0	0.5	-0.8	0.1	-0.1
Peak expiratory flow (PEF)	0.7	1.7	5.1	0.6	0.5	-0.2	0.9	-2.0	2.3	-1.1
Pulse wave reflection index	0.3	0.4	0.7	0.7	-0.7	-0.2	-0.7	0.4	-0.8	0.5
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.7	0.0	-0.5	0.5	-0.5	1.3	-0.7	-0.0
Loud music exposure frequency	0.7	0.8	2.3	-0.4	-0.7	0.2	-1.1	1.5	-1.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.9	0.1	0.2	0.1	-1.0	0.4	0.3
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.0	-1.8	0.2	-0.7	-2.0	1.7	-1.5	1.5
Blood clot in the leg (DVT)	3.1	4.0	6.5	0.5	-0.7	2.0	2.4	-2.3	2.4	-2.5
Medication: Paracetamol	0.3	0.5	0.9	0.4	-0.8	0.8	0.6	-0.2	0.8	-1.0
Headache pain in last month	0.5	0.8	1.5	1.2	-1.1	0.7	-0.1	0.5	0.9	-1.2
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	4.3	-0.7	2.1	-0.8	-2.0	2.1	-1.9	2.0
Glaucoma (self-reported)	0.4	0.4	0.9	0.8	-0.8	0.3	-1.0	0.5	0.3	-0.7
Gout (self-reported)	0.5	0.6	3.1	-0.5	-0.3	1.8	-0.0	0.7	0.3	-0.7
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.3	0.6	-1.8	1.1	2.1	-1.1	1.6	-1.2
Medication: Amlodipine	0.3	0.4	1.8	0.1	-1.4	0.2	-0.1	-0.2	0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.1	-0.5	1.4	0.3	-0.0	-1.2	-0.3	0.4
Birth weight	0.8	1.7	2.7	-1.2	1.5	-1.4	1.6	-1.1	1.4	0.3
Chronic bronchitis/emphysema (mother)	1.2	1.3	4.0	-0.6	-1.6	0.8	-1.0	2.0	-0.9	0.2
High blood pressure (siblings)	1.1	1.5	5.3	-1.6	2.3	-0.9	-0.8	0.5	-0.4	1.0
Forced vital capacity (FVC), Best measure	1.6	6.0	15.2	-1.8	2.0	-1.5	3.1	-3.9	2.7	-0.2
Body fat percentage	0.4	1.7	3.1	1.2	-1.3	1.6	1.2	0.1	1.4	-1.8
Leg fat percentage (right)	0.1	0.5	1.9	-0.6	-0.6	1.4	0.4	0.5	0.4	-0.6
Arm fat-free mass (right)	1.0	5.3	15.8	-0.5	1.7	-1.4	2.6	-4.0	2.9	-1.0
Exposure to tobacco smoke outside home	0.4	0.5	1.3	1.1	-0.6	-1.1	-0.3	0.2	-0.7	0.4
Comparative body size at age 10	0.5	1.4	2.6	-0.4	-0.0	1.5	1.6	-1.6	1.0	-0.9
Number of full brothers	0.9	1.2	3.4	1.1	-0.9	1.8	1.5	-0.2	0.1	-0.7
Worry too long after embarrassment	0.7	1.2	5.8	-0.6	2.4	-0.9	-0.0	-0.7	-0.3	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.5	1.7	-1.2	1.1	1.5	-1.5	1.7	-1.9
Wheeze or whistling in the chest in last year	0.3	0.5	2.6	0.9	-0.0	1.6	-0.1	0.5	-0.2	-0.5
Number of children fathered	0.9	1.0	1.8	0.3	-0.6	-0.1	1.3	-1.2	1.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	-0.9	-0.4	0.7	-0.7	0.0	0.1	-0.1
Age at first live birth	0.7	1.3	3.5	-1.9	0.5	-1.5	-0.6	-1.0	-0.1	1.3
Pulse wave peak to peak time	1.8	2.2	5.2	-2.0	0.3	0.6	2.0	-2.3	1.2	-0.5
Health satisfaction	0.1	0.2	0.7	-0.3	-0.8	0.2	-0.1	0.5	0.1	0.0
Shortness of breath walking on level ground	0.2	0.3	1.0	-0.4	0.2	0.1	-1.0	0.1	-0.6	0.6
Qualifications: College or University degree	0.2	0.8	1.6	-0.1	1.0	-1.3	-0.9	-1.1	0.4	0.8
Eye problems/disorders: None of the above	0.3	0.4	1.2	-1.0	1.1	-0.1	0.7	0.2	0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.3	1.0	-1.5	0.3	-0.4	0.5	-0.0	-0.4
Emphysema/chronic bronchitis	0.2	0.2	0.7	0.2	-0.4	0.3	-0.4	0.0	-0.9	0.5
Medication for pain relief, constipation, heartburn	0.7	1.3	4.2	-1.3	2.0	-1.2	0.0	-0.4	-0.4	1.0
Neck or shoulder pain in last month	1.6	2.2	5.3	2.3	-1.4	1.7	1.1	0.6	1.2	-1.6
Medication: Blood pressure	0.6	1.1	2.5	0.9	-1.6	0.6	0.5	-1.1	0.8	-1.4
Angina (self-reported)	0.4	0.6	1.9	1.4	-1.1	0.6	-0.1	0.0	-0.6	-0.4
Migraine (self-reported)	2.5	3.1	6.8	1.7	-2.3	1.9	0.4	0.1	1.6	-2.6
Medication: Ibuprofen	0.2	0.2	0.9	0.5	-0.1	-0.9	-0.1	0.0	-0.2	0.4
Medication: Allopurinol	0.5	0.6	1.6	-0.6	0.5	1.1	-0.8	1.3	-0.5	0.3
Medication: Omeprazole	2.5	2.9	6.4	1.3	-1.8	2.1	-1.7	2.5	-1.1	-0.7
Medication: Seretide 50 evohaler	0.4	0.5	2.7	-0.1	1.6	-0.1	-0.3	-0.6	-0.3	0.3
Mean time to correctly identify matches	1.3	2.5	5.6	1.2	-1.1	-0.0	2.4	-1.9	1.9	-1.4
Heart disease (mother)	1.0	1.2	4.9	-0.1	-1.0	0.2	-1.4	2.2	-0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.5	0.7	-0.5	2.1	1.6	-1.0	1.3	-1.6
Whole body fat mass	0.7	2.9	5.8	1.2	-1.0	1.3	2.0	-1.3	2.4	-2.2
Leg fat mass (right)	0.4	1.5	3.0	-0.1	-0.6	1.0	1.6	-1.2	1.7	-1.4
Arm predicted mass (right)	1.0	5.1	15.4	-0.5	1.7	-1.6	2.4	-3.9	2.8	-0.9
Pulse rate, automated reading	1.7	5.6	17.8	1.2	-2.5	-0.7	-2.6	4.2	-2.2	1.3
Alcohol intake frequency.	0.2	0.5	1.3	0.7	0.1	1.1	0.5	0.7	0.4	-0.7
Comparative height size at age 10	0.7	3.7	7.6	0.6	0.5	-1.8	2.5	-2.8	2.7	-0.9
Number of full sisters	1.1	1.3	4.4	2.1	-0.8	1.2	-0.6	1.1	0.6	-1.1
Suffer from ‘nerves’	0.6	0.9	3.2	1.8	-0.8	0.9	-0.4	1.2	-0.4	-0.4
Overall health rating	0.5	1.2	2.5	1.6	-1.2	1.3	-0.2	0.7	0.7	-1.2
Chest pain or discomfort	0.5	0.7	2.7	0.3	0.2	0.4	-1.6	0.4	-0.9	0.8
Had major operations	0.7	0.9	2.1	1.4	-1.4	-0.5	-0.4	1.0	-0.7	0.2
Age at last live birth	0.2	0.3	0.7	-0.7	-0.1	-0.1	-0.2	-0.8	-0.5	0.7
Family relationship satisfaction	0.9	1.1	2.8	0.4	-0.7	-0.4	-1.7	1.5	-1.3	0.4
Leg pain on walking	2.3	2.9	5.0	1.8	-1.9	1.3	1.7	-1.1	1.7	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	2.2	0.0	0.3	-1.5	-0.5	-0.1	-0.3	1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	-1.5	0.6	0.5	0.5	-1.4	-0.2	0.4
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	8.9	-0.2	-3.0	1.5	0.7	0.7	1.4	-1.5
Medication: Aspirin	0.5	0.7	2.9	-0.4	-1.7	0.3	-1.0	0.5	0.4	-0.3
Supplements: Vitamin C	1.0	1.2	3.6	0.6	1.3	-0.3	0.8	-1.9	1.2	-0.8
Knee pain experienced in last month	2.7	4.1	6.7	2.1	-2.6	1.2	2.2	-1.4	2.2	-2.2
Hypertension (Self-reported)	0.6	1.6	3.3	0.1	-1.5	1.8	-0.1	-0.7	1.5	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.8	0.7	1.1	-1.4	-0.2	0.8	-1.0	0.8
Illnesses of father: Heart disease	0.7	1.0	3.0	0.7	-1.7	0.8	0.9	-1.2	0.6	-0.7
Illnesses of siblings: Diabetes	1.0	1.2	5.8	0.1	-0.6	2.4	-0.4	1.2	-0.2	-0.8
Smoking status: Previous	0.5	0.7	3.1	-0.7	-1.8	0.9	-0.1	0.7	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	6.4	-0.3	1.7	-2.5	0.3	-1.2	-0.4	1.4
Whole body fat-free mass	1.1	6.3	20.2	-0.2	1.5	-1.3	2.9	-4.5	3.1	-1.2
Leg fat-free mass (right)	1.2	6.7	20.9	0.7	0.7	-0.5	3.2	-4.6	3.3	-1.9
Arm fat percentage (left)	0.9	3.5	6.2	1.5	-1.6	2.5	1.7	-0.7	1.9	-2.5
Average weekly red wine intake	0.7	1.1	3.2	-0.6	0.9	-1.8	0.8	-1.3	0.1	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.5	-1.6	0.9	-0.4	0.4	-0.6	-0.0	1.2
Mood swings	0.5	0.8	1.9	1.4	-0.6	1.1	-0.9	1.0	-0.4	-0.5
Loneliness, isolation	0.6	0.8	3.2	1.8	-1.2	0.8	0.1	0.3	0.1	-0.7
Long-standing illness, disability or infirmity	0.5	0.8	4.2	2.0	-0.6	0.7	0.3	-0.3	-0.4	-0.5
Ever had bowel cancer screening	0.1	0.2	0.4	0.6	-0.1	-0.1	0.3	-0.5	0.5	-0.4
Diabetes diagnosed by doctor	1.1	1.8	5.9	1.3	-2.4	1.4	-1.0	1.0	-0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.4	1.2	-0.9	-0.1	1.1	-0.6	0.6	-0.6
Friendships satisfaction	1.1	1.4	2.3	-0.9	1.2	-0.9	-1.5	0.4	-1.4	1.5
Qualifications: nursing, teaching	0.2	0.2	0.6	-0.6	0.4	0.1	-0.7	-0.2	0.7	-0.2
Commuting to job workplace: Walk	1.7	1.8	4.0	1.4	-1.0	0.1	1.5	-0.9	2.0	-1.7
Eye problems/disorders: Cataract	0.7	0.8	2.7	0.9	-1.6	1.1	0.3	-0.5	0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	6.5	0.1	-2.2	2.6	1.7	-2.4	2.2	-2.2
Medication for cholesterol	0.1	0.1	0.4	-0.7	-0.1	0.2	0.6	-0.1	0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	6.2	0.2	-0.3	-1.0	-1.5	2.5	-2.2	1.9
Back pain experienced in last month	1.0	1.5	2.6	1.3	-1.2	0.8	1.6	-1.2	1.0	-1.3
Mineral and other dietary supplements	2.1	2.8	10.4	1.4	-3.2	1.4	0.2	-0.1	1.6	-1.7
Breast cancer (self-reported)	0.2	0.3	1.6	1.3	-0.3	-0.0	-0.1	0.5	-0.1	0.0
Asthma (self-reported)	2.8	5.6	13.2	-3.6	2.8	0.3	-3.4	0.3	-1.9	1.8
Osteoporosis (self-reported)	0.2	0.2	0.6	0.6	0.8	-0.2	0.4	-0.6	-0.0	0.1
Osteoarthritis (self-reported)	0.5	0.6	2.0	1.4	-0.8	-0.4	1.0	-0.0	0.4	-0.7
Medication: Aspirin	0.7	0.9	2.5	-0.6	-1.6	0.2	-1.5	1.1	0.0	0.0
Medication: Gliclazide	1.2	1.4	1.9	-1.2	-0.7	-0.7	-1.4	1.3	-1.4	1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	3.5	-0.5	1.2	-1.9	-0.7	0.5	-0.7	1.0
Smoking status: Current	1.9	3.1	7.8	2.8	-1.9	1.8	1.4	0.3	1.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	11.3	-1.8	1.6	-0.1	2.2	-3.4	2.4	-0.9
Whole body water mass	1.1	6.2	19.6	-0.2	1.6	-1.6	2.8	-4.4	3.0	-1.1
Leg predicted mass (right)	1.3	6.7	21.1	0.8	0.6	-0.5	3.2	-4.6	3.3	-1.9
Arm fat mass (left)	0.9	3.6	6.0	1.3	-0.8	1.7	2.2	-1.9	2.5	-2.4
Number of self-reported non-cancer illnesses	0.8	1.4	3.8	0.8	-1.2	1.9	0.5	-0.8	0.9	-1.5
Average weekly champagne plus white wine intake	1.8	2.5	5.7	0.7	-2.4	2.3	0.7	-0.9	1.4	-1.5
Miserableness	1.6	2.8	9.4	1.6	-1.3	3.1	0.7	-0.6	1.1	-2.0
Guilty feelings	0.4	0.5	1.6	1.3	0.8	-0.1	-0.7	0.9	0.1	-0.3
Wears glasses or contact lenses	0.3	0.4	1.4	-0.7	0.5	0.2	-0.6	1.2	0.1	-0.1
Ever taken oral contraceptive pill	2.2	2.5	5.4	2.3	-2.1	-0.1	-1.3	2.3	-0.5	-0.3
Hearing aid user	1.0	1.1	3.5	1.9	-1.3	-0.4	0.3	-0.5	1.1	-1.0
Mother’s age at death	0.6	0.7	2.1	0.4	1.1	-0.8	1.5	-0.4	0.6	-0.2
Financial situation satisfaction	0.5	0.7	3.4	1.9	-0.8	0.5	0.3	0.0	-0.6	-0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.2	1.1	0.1	0.6	0.5	-1.0	1.2	-1.5
Commuting to job workplace: Public transport	1.3	1.6	3.1	1.8	-1.6	0.6	-1.1	1.2	0.8	-1.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.2	-0.2	-0.0	-0.8	0.6	0.2	-0.5
Medication: Blood pressure	0.2	0.4	1.2	-0.6	0.3	0.8	-1.1	0.6	0.1	0.1
Pain type(s) experienced in last month: Hip pain	1.6	2.1	5.1	2.3	-0.8	0.8	1.6	-0.7	1.6	-1.6
Supplements: Fish oil (including cod liver oil)	1.8	2.4	6.9	-2.0	2.6	-1.2	-0.5	0.1	-1.4	1.4
High cholesterol (Self-reported)	0.7	1.2	3.4	-0.5	-0.7	0.9	-1.5	1.9	-1.1	0.4
Medication: Bendroflumethiazide	0.3	0.5	1.3	-1.1	0.9	0.1	-0.9	0.7	-0.3	0.1
Medication: Paracetamol	0.1	0.1	0.3	0.6	-0.4	0.4	0.1	0.3	0.4	-0.4
Medication: Lisinopril	0.3	0.4	1.8	-1.3	0.1	0.2	-0.4	-0.7	0.5	0.0
Medication: Atorvastatin	0.3	0.3	0.7	0.2	-0.9	-0.0	-0.8	0.6	-0.7	-0.1
Illnesses of father: High blood pressure	1.9	2.4	3.9	-1.2	1.7	-0.5	-1.9	1.1	-2.0	2.0
Alcohol drinker status: Never	0.4	0.4	1.3	0.7	-0.1	-0.5	1.0	-1.1	0.2	0.2
Ever smoked	0.7	1.3	3.0	-0.1	-1.4	1.7	-0.9	1.7	-0.2	-0.5
Basal metabolic rate	1.0	5.5	17.3	0.0	1.2	-1.0	2.8	-4.2	3.1	-1.4
Leg fat percentage (left)	0.2	0.8	2.9	-0.2	-0.7	1.7	0.6	0.4	0.6	-1.0
Arm fat-free mass (left)	1.0	4.9	15.3	-0.6	1.7	-1.5	2.4	-3.9	2.6	-0.7
Number of operations (self-reported)	0.8	1.2	4.0	0.9	-2.0	1.1	0.6	-0.6	0.7	-1.1
Average weekly beer plus cider intake	0.4	0.6	2.2	-0.0	-1.5	0.9	-0.5	0.4	0.6	-0.8
Irritability	2.6	4.4	10.8	2.9	-2.5	3.3	-0.5	1.2	0.2	-1.9
Risk taking	0.6	0.9	2.7	1.7	-0.5	0.9	0.8	-0.6	0.6	-1.1
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.4	0.4	0.1	0.2	0.9	-0.8	1.2	-0.9
Fractured/broken bones in last 5 years	0.8	1.1	2.2	-1.1	0.7	-0.9	-1.0	0.7	-1.5	1.1
Age started oral contraceptive pill	0.6	0.8	2.2	1.3	0.6	-1.5	0.8	-0.5	-0.4	0.5
Diastolic blood pressure, automated reading	1.1	3.5	7.6	0.3	-2.8	1.5	1.6	-1.6	2.1	-2.1
Ever depressed for a whole week	0.5	0.6	1.3	1.1	-1.0	0.3	-0.8	1.1	-0.4	-0.2
Unable to work because of sickness or disability	2.1	2.7	5.6	2.0	-1.7	2.4	0.6	0.6	1.2	-1.9
Commuting to job workplace: Cycle	0.7	0.9	3.2	-0.0	0.5	-1.8	-1.1	0.4	-0.8	0.9
Myopia	0.2	0.3	0.6	0.7	0.2	0.3	0.3	-0.4	0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.8	-0.2	1.3	-1.1	0.0	0.3	-1.0	1.1
Cholesterol lowering medication	1.5	2.2	4.6	-0.8	0.8	-0.7	-2.1	2.0	-1.8	1.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.8	1.3	-1.1	1.6	-1.9	2.4	-0.8	-0.7
Pain experienced in last month	4.0	6.7	10.0	-3.0	2.7	-1.6	-3.2	1.7	-2.7	2.7
Supplements: Calcium	1.8	2.0	3.1	0.8	1.3	-1.8	-1.1	1.1	-1.7	1.7
Basal cell carcinoma (self-reported)	2.1	2.5	4.9	-0.3	-2.2	1.3	1.3	-1.4	1.9	-1.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.6	-0.3	-0.6	-1.0	-1.3	0.9	-1.1	1.2
Deep venous thrombosis (DVT) (self-reported)	2.9	3.7	6.0	0.3	-0.9	2.1	2.2	-2.1	2.3	-2.5
Heart disease (siblings)	0.5	0.6	2.1	-0.4	0.2	-0.7	1.1	-1.4	0.4	0.2
Alcohol drinker status: Previous	1.2	1.3	5.9	1.0	-1.1	0.4	-0.7	2.4	-0.6	-0.1
Pack years of smoking	0.8	1.1	3.9	1.3	-2.0	0.1	0.8	0.0	0.7	-1.0
Impedance of whole body	0.5	2.3	9.1	1.0	-1.6	0.2	-1.3	3.0	-1.2	0.5
Leg fat mass (left)	0.4	1.6	3.2	0.2	-0.7	1.2	1.6	-1.2	1.8	-1.5
Arm predicted mass (left)	0.9	4.4	14.2	-0.6	1.3	-1.3	2.4	-3.8	2.5	-0.8