TWAS hub - ZNF683

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0381	0.0162	1.6e-03	0.002	0.005	0.003	0.006	0.001	1.4e-01	5.8e-02	9.6e-02	3.6e-02	1.8e-01
2	YFS	Blood	0.0907	0.0212	0.0e+00	0.070	0.069	0.086	0.078	0.087	5.5e-22	1.0e-21	9.5e-27	2.4e-24	5.4e-27
3	TCGA	Breast Invasive Carcinoma	0.0247	0.0104	1.5e-05	0.010	0.025	0.029	NA	0.024	2.5e-03	6.1e-06	1.1e-06	NA	7.4e-06
4	TCGA	Lung Adenocarcinoma	0.0941	0.0462	6.8e-05	0.031	0.022	0.015	NA	0.020	1.5e-04	1.1e-03	6.1e-03	NA	2.0e-03
5	TCGA	Lung Squamous Cell Carcinoma	0.0276	0.0150	5.6e-03	0.007	0.021	0.013	NA	0.014	4.4e-02	1.7e-03	1.2e-02	NA	9.8e-03
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.1700	0.0790	3.0e-03	0.075	0.067	0.064	NA	0.071	4.0e-03	6.3e-03	7.6e-03	NA	5.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Allergy	7.4	16.9	24.8	2.1	5.0	3.8	4.4	4.7	4.2
Medication for hormone replacement therapy	6.8	7.6	14.3	1.9	1.8	3.8	2.7	3.4	2.3
Hayfever, allergic rhinitis or eczema	6.6	14.3	19.4	-2.4	-4.4	-3.6	-4.1	-4.1	-3.8
Medication: Allopurinol	6.4	8.6	10.6	-3.3	-2.6	-3.1	-3.2	-2.6	-2.7
Asthma	6.1	12.0	16.5	-2.0	-3.9	-3.3	-3.5	-4.1	-3.6
Noisy workplace	5.7	7.0	11.2	0.9	3.0	3.2	2.5	3.4	2.1
Asthma (self-reported)	5.0	9.9	14.2	-1.8	-3.6	-3.0	-3.1	-3.8	-3.3
Knee pain experienced in last month	4.7	7.3	9.7	2.3	2.6	3.1	2.6	2.8	2.7
Gout (self-reported)	4.6	6.3	8.0	-2.5	-2.6	-2.3	-2.8	-2.3	-2.5
Osteoarthritis (self-reported)	4.4	5.7	6.9	2.2	2.2	2.3	2.4	2.6	2.6
Falls in the last year	4.0	5.4	8.3	1.3	2.1	2.9	2.7	2.6	1.9
HDL Cholesterol	3.9	6.5	16.9	4.1	1.4	2.4	2.7	2.1	1.7
Other serious medical condition/disability diagnosed by doctor	3.9	5.1	8.1	1.1	1.9	2.9	2.7	2.2	2.4
Breastfed as a baby	3.8	4.7	7.4	2.7	2.3	1.9	2.0	1.7	2.2
Medication: Lisinopril	3.6	4.7	6.8	-2.6	-2.1	-2.1	-2.2	-2.5	-1.3
Allergy or Eczema	3.5	9.2	12.2	-2.1	-3.4	-2.7	-3.5	-3.2	-3.1
Pain experienced in last month	3.4	5.7	7.1	-1.6	-2.4	-2.7	-2.7	-2.6	-2.3
Blood Platelet Count	3.3	38.4	114.5	-10.7	-4.8	-5.0	-4.9	-5.3	-4.0
Ever taken oral contraceptive pill	3.2	3.6	5.4	2.0	1.5	1.5	1.8	2.1	2.3
Triglycerides	3.1	5.0	12.1	-3.5	-1.5	-1.4	-2.8	-1.4	-2.1
Commuting to job workplace: Walk	2.9	3.1	4.9	1.1	1.4	2.0	2.0	1.6	2.2
Blood Eosinophil Count	2.8	21.5	33.4	-5.8	-5.0	-3.8	-4.1	-4.2	-4.7
Fluid intelligence score	2.8	5.7	8.7	-2.9	-2.2	-2.6	-1.9	-2.7	-1.8
Verbal and Numeric Reasoning (VNR)	2.7	6.6	10.7	-3.3	-2.0	-2.7	-2.3	-3.1	-1.5
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	5.3	-1.0	-2.3	-1.2	-2.1	-2.0	-2.3
Mean Putamen Volume	2.6	3.0	4.6	-1.3	-1.4	-2.1	-1.6	-2.1	-1.6
Alcohol usually taken with meals	2.6	4.2	5.2	1.6	2.3	2.2	2.2	2.0	2.0
Length of working week for main job	2.6	2.8	4.4	-1.3	-1.5	-1.7	-1.6	-2.1	-1.8
High blood pressure (siblings)	2.6	3.8	9.6	-3.1	-1.4	-1.7	-1.6	-2.3	-0.9
Pack years of smoking	2.6	3.8	5.4	0.4	1.9	2.3	2.3	2.3	1.7
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.6	3.3	1.7	1.8	1.6	1.2	1.8	1.6
Fasting Glucose	2.4	2.8	5.9	0.5	1.8	2.4	1.2	1.8	1.6
Pack years adult smoking proportion	2.4	3.7	5.4	0.2	1.9	2.3	2.2	2.3	1.7
Chest pain or discomfort	2.4	3.4	4.5	-2.1	-2.1	-1.4	-2.1	-1.3	-1.8
Smoking status: Current	2.4	3.8	5.1	0.2	2.2	1.9	2.1	2.3	2.2
Mean time to correctly identify matches	2.3	4.3	6.5	2.5	1.8	1.8	2.3	1.9	2.0
Serious illness, injury or assault to yourself	2.2	2.7	4.3	1.8	1.3	2.1	1.5	1.8	1.1
Medication: Blood pressure	2.0	3.8	13.8	-3.7	-1.2	-1.6	-1.0	-1.7	-1.1
Medication: Bendroflumethiazide	2.0	3.0	11.9	-3.4	-1.0	-1.3	-0.9	-1.3	-1.1
Current tobacco smoking	1.9	3.1	4.6	0.1	1.9	1.9	1.9	2.1	1.8
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	5.5	-1.4	-2.4	-1.7	-1.5	-1.4	-2.0
Exposure to tobacco smoke at home	1.9	2.1	3.3	1.8	1.7	0.6	1.2	1.8	1.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	3.2	-1.0	-1.5	-1.8	-1.8	-1.8	-1.3
Father’s age at death	1.8	2.4	4.1	1.9	2.0	0.4	1.9	1.2	1.0
Bipolar Disorder (2011)	1.7	1.7	3.0	0.3	-1.7	-1.1	-1.6	-1.2	-1.4
LDL Cholesterol	1.7	2.8	8.9	-3.0	-1.3	-0.6	-1.7	-0.6	-1.6
Medication: Levothyroxine sodium	1.7	2.9	5.9	0.9	1.4	2.4	1.7	1.9	1.3
High blood pressure (mother)	1.7	2.4	12.0	-3.5	-0.9	-0.3	-0.7	-0.8	-0.5
Had other major operations	1.7	2.0	5.3	0.8	1.2	2.3	0.7	1.8	1.1
High cholesterol (Self-reported)	1.7	3.0	10.2	-3.2	-1.5	-0.7	-1.9	-0.8	-1.0
Reaction Time	1.6	3.1	6.5	2.5	1.4	1.3	1.9	1.5	1.7
Respiratory disease	1.6	3.5	5.4	-1.1	-2.0	-1.5	-2.0	-2.3	-2.0
Blood clot in the leg (DVT)	1.6	2.1	6.8	2.6	1.0	0.7	1.2	0.6	1.7
Comparative height size at age 10	1.6	8.6	13.3	-1.2	3.6	2.8	3.0	2.6	3.6
Irritability	1.6	2.7	5.5	2.4	1.1	1.7	1.0	2.1	1.0
Age started oral contraceptive pill	1.6	2.0	3.4	-0.4	1.4	1.7	1.3	1.8	1.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.7	0.3	1.2	1.9	1.0	1.9	1.2
Time employed in main current job	1.5	1.7	2.9	1.2	1.7	1.3	1.4	1.3	1.0
Depression (self-reported)	1.5	1.8	3.3	0.5	1.7	1.2	0.9	1.4	1.8
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.0	-1.0	-1.5	-1.1	-1.1	-1.0	-2.0
Leg pain on walking	1.5	1.8	3.5	0.0	1.1	1.9	1.3	1.9	1.1
Wears glasses or contact lenses	1.5	1.7	7.8	-2.8	-0.5	-0.8	-0.8	-0.8	-0.7
Hearing aid user	1.5	1.7	4.0	0.5	1.2	0.9	1.3	1.3	2.0
Intelligence (Savage-Jansen 2018)	1.4	4.3	10.4	-3.2	-1.7	-1.8	-1.7	-2.1	-1.4
Financial difficulties in last 2 years	1.4	1.9	4.0	1.5	1.9	0.3	0.4	1.2	2.0
Cholesterol lowering medication	1.4	2.1	9.9	-3.1	-0.8	-0.3	-0.9	-0.3	-1.0
Alzheimer’s Disease (in mother)	1.3	1.6	2.4	0.8	-1.6	-1.3	-0.8	-1.4	-1.4
Illnesses of siblings	1.3	1.8	7.2	2.7	0.6	0.6	0.5	1.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.5	1.3	1.6	1.4	1.3	1.2	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.2	-0.1	-1.4	-1.4	-1.4	-1.5	-0.8
Illnesses of siblings: Diabetes	1.3	1.6	2.8	-1.7	-1.7	-0.4	-1.4	-1.3	-0.6
Osteoporosis (self-reported)	1.3	1.6	3.0	1.3	0.8	1.7	1.5	1.2	0.9
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	7.0	2.6	0.7	0.7	0.9	0.4	1.2
Irritable Bowel Disease (IBD)	1.2	2.8	6.1	-2.5	-1.0	-1.8	-1.7	-1.5	-1.0
Major Depression (MDD)	1.2	1.5	3.3	-0.1	-1.8	-0.7	-0.9	-1.5	-1.4
Supplements: Zinc	1.2	1.4	1.8	0.6	1.1	1.3	1.3	1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	10.9	0.6	2.6	1.1	1.6	1.0	3.3
Exposure to tobacco smoke outside home	1.2	1.6	3.8	0.5	1.5	1.2	0.8	2.0	1.3
Shortness of breath walking on level ground	1.2	1.4	4.0	-2.0	-1.2	-0.8	-1.0	-1.0	-0.5
Ulcerative Colitis (UC)	1.1	2.0	4.0	-2.0	-0.7	-2.0	-1.4	-1.1	-0.8
Neuroticism (2016)	1.1	1.5	2.7	-1.3	-1.3	-1.1	-0.8	-1.0	-1.6
Systolic Blood Pressure	1.1	5.7	13.1	-3.6	-2.3	-1.1	-2.4	-1.9	-2.3
Sitting height	1.1	7.6	14.4	-1.8	3.8	1.8	2.5	2.1	3.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.6	-1.0	-0.4	-1.9	-1.6	-0.7	-0.6
Neck or shoulder pain in last month	1.1	1.5	2.0	0.8	1.3	1.2	1.2	1.4	1.4
Supplements: Vitamin C	1.1	1.3	3.1	1.4	1.1	0.8	1.8	0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	3.9	-1.1	1.9	0.9	1.2	1.6	2.0
Average weekly red wine intake	1.1	1.6	3.5	1.3	1.4	0.8	0.8	1.0	1.9
Schizophrenia (2014)	1.0	2.1	5.5	2.4	0.9	1.3	1.4	1.4	1.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.9	-1.0	-1.7	-0.3	-0.9	-0.6	-2.4
Systolic blood pressure, automated reading	1.0	2.8	6.7	-2.6	-1.1	-1.5	-1.8	-1.7	-1.0
Angina	1.0	1.3	2.3	-0.2	1.2	1.3	0.7	1.5	1.4
High blood pressure	1.0	2.9	11.6	-3.4	-1.3	-0.8	-1.0	-1.4	-0.8
Medication: Atenolol	1.0	1.3	2.4	-0.9	1.4	0.8	0.9	1.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.0	0.4	1.4	1.3	1.1	1.4	0.7
Hair/balding pattern: Pattern 4	1.0	2.4	4.8	1.6	1.1	1.2	1.5	2.2	1.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.9	0.1	1.5	2.0	1.1	1.5	1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.4	-0.7	0.9	1.0	1.6	1.0	1.1
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.0	0.9	1.1	1.2	1.2	1.1	1.4
Cardiovascular Disease	0.9	3.0	13.5	-3.7	-1.2	-0.4	-1.1	-0.9	-1.0
Hearing difficulty/problems: Yes	0.9	1.4	2.8	0.3	1.5	0.7	1.0	1.7	1.3
Severe depression (siblings)	0.9	1.0	1.7	0.4	1.0	0.9	1.2	1.1	1.3
Loud music exposure frequency	0.9	1.0	2.0	-1.4	-1.2	-0.1	-1.3	-0.3	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.1	9.3	-0.0	2.5	0.9	1.4	0.6	3.0
Medication: Omeprazole	0.9	1.1	2.8	-1.0	-1.7	-1.1	-1.0	-0.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.9	0.2	1.0	1.1	0.6	1.4	1.2
Qualifications: nursing, teaching	0.9	1.4	5.2	-2.3	-1.3	-0.3	-0.5	-0.8	-0.7
Risk taking	0.9	1.3	2.1	1.2	0.8	1.4	1.2	1.3	0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	1.5	0.8	-1.2	-1.2	-1.2	-1.2	-0.7
Smoking Status	0.8	1.8	3.0	0.6	1.0	1.7	1.1	1.7	1.4
Number of treatments/medications taken	0.8	1.4	2.2	-1.2	0.9	1.5	1.4	1.2	0.9
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	-1.2	-1.3	0.8	0.3	0.3	-1.2
Maternal smoking around birth	0.8	1.2	5.3	2.3	-0.8	0.1	0.2	0.1	-1.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.5	-0.7	-0.3	1.6	1.0	1.0	0.2
Hearing difficulty/problems with background noise	0.8	1.4	2.6	1.5	1.1	1.1	0.6	1.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.2	1.1	-1.1	-2.0	-0.1	-1.6	-1.4
Standing height	0.8	8.3	16.5	-2.1	3.6	1.9	2.6	2.2	4.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.0	-2.0	-0.9	-1.0	-0.8	-1.2	-0.2
Number of children fathered	0.8	0.9	2.4	1.6	0.7	0.6	1.3	0.6	0.6
Angina (self-reported)	0.8	1.1	1.8	-0.4	1.0	1.2	0.6	1.4	1.4
Medication: Ibuprofen	0.8	0.9	1.9	-0.2	1.0	1.4	1.0	1.1	0.5
Hypertension (Self-reported)	0.8	2.3	10.0	-3.2	-1.2	-0.7	-0.6	-1.1	-0.6
Eye problems/disorders: Glaucoma	0.8	1.0	2.2	0.5	-1.0	-1.5	-0.3	-1.3	-0.8
Illnesses of father: High blood pressure	0.8	1.0	1.7	-0.7	-1.0	-1.3	-1.0	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.4	-1.1	-1.5	-0.9	-0.8	-0.4	-0.7
Schizophrenia vs Biploar Disorder	0.7	0.9	1.5	-0.4	1.1	0.9	1.1	0.9	1.2
Ulcerative Colitis	0.7	1.1	3.5	-1.9	-0.4	-1.1	-0.7	-0.2	-0.9
Chronotype (morning person)	0.7	1.5	9.0	3.0	0.0	-0.1	0.5	0.1	-0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.1	-0.0	-1.5	-0.5	-0.9	-0.6	-1.4
Medication: Ramipril	0.7	0.9	2.1	0.6	0.7	1.1	0.8	1.5	0.8
Prospective memory result	0.7	0.8	1.9	-0.5	-0.4	-1.1	-0.8	-0.9	-1.4
Leg fat percentage (right)	0.7	2.6	4.2	-1.1	-1.8	-1.1	-1.6	-1.7	-2.1
Emphysema/chronic bronchitis	0.7	0.8	1.6	0.9	0.6	1.3	0.3	1.1	0.8
Illnesses of father: Heart disease	0.7	1.0	1.9	0.7	0.9	1.4	1.2	1.2	0.2
Medication: Aspirin	0.7	0.9	3.3	-1.8	-1.0	-0.1	-0.7	-0.5	-0.6
Financial situation satisfaction	0.7	0.9	2.5	0.4	0.9	1.4	0.4	1.6	0.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.3	-0.8	-1.1	-0.9	-1.0	-1.2	-1.0
Age at First Birth	0.6	0.8	1.8	1.4	0.8	1.2	0.4	0.7	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	1.3	-0.1	0.9	0.8	1.1	0.1
Sensitivity / hurt feelings	0.6	1.0	2.3	-1.2	-0.8	-1.5	-0.9	-0.9	-0.5
Average weekly fortified wine intake	0.6	0.7	1.7	-0.8	-0.4	-1.0	-0.7	-1.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	-0.6	1.1	0.8	0.6	1.3	1.2
Medication: Amlodipine	0.6	0.9	2.1	0.3	0.6	1.3	1.4	1.0	0.2
Age at first live birth	0.6	1.0	2.3	-0.5	-1.0	-1.2	-1.0	-1.5	-0.5
Smoking status: Previous	0.6	0.9	1.7	1.1	-1.2	-0.2	-1.3	-0.6	-0.9
Loneliness, isolation	0.6	0.8	1.8	0.1	1.2	1.0	0.7	1.3	0.4
Ever had bowel cancer screening	0.6	0.7	1.5	0.3	-0.8	-1.2	-0.6	-1.2	-0.3
Average weekly beer plus cider intake	0.6	0.9	1.7	0.5	-0.9	-1.1	-1.3	-1.0	-0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.9	1.7	-0.2	0.8	0.4	-0.3	0.5
Ever depressed for a whole week	0.6	0.7	1.7	-1.3	-0.5	-0.8	-0.9	-0.5	-0.9
Vascular/heart problems diagnosed by doctor	0.6	1.5	7.6	2.8	0.7	0.3	0.7	0.7	0.4
Bipolar Disorder (2018)	0.5	0.8	1.9	1.1	-1.0	-0.7	-0.6	-0.5	-1.4
Height	0.5	9.1	21.2	-4.6	3.6	0.1	2.7	1.1	3.5
Diabetes (mother)	0.5	0.7	1.3	-0.3	-0.8	-0.9	-1.1	-0.7	-0.9
Medication: Simvastatin	0.5	0.7	3.6	-1.9	-0.1	0.5	-0.5	0.3	0.3
Alcohol intake versus 10 years previously	0.5	0.8	2.0	-1.4	-0.8	-0.6	-0.2	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	6.3	0.0	1.7	0.1	1.1	0.2	2.5
Happiness	0.5	0.7	1.9	0.3	0.5	1.3	0.3	1.4	0.2
Illnesses of mother	0.5	0.6	3.2	1.8	-0.2	0.2	0.4	0.4	0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.1	1.0	0.9	0.5	1.1	0.3
Glaucoma (self-reported)	0.5	0.6	0.9	0.9	-1.0	-0.9	-0.2	-0.7	-0.7
Comparative body size at age 10	0.5	1.3	2.6	0.2	-1.2	-1.2	-1.6	-1.4	-0.5
Heart disease (mother)	0.5	0.6	2.0	-1.4	0.7	0.4	0.2	0.5	0.6
Medication: Aspirin	0.5	0.6	2.8	-1.7	-0.7	0.3	-0.4	-0.1	-0.5
Leg fat-free mass (right)	0.5	2.6	4.6	0.6	2.1	1.4	1.8	1.1	2.1
Long-standing illness, disability or infirmity	0.5	0.7	1.3	1.2	0.3	1.1	0.6	1.0	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.7	1.6	0.3	0.9	0.6	0.4	0.5
Medication for cholesterol	0.5	0.7	3.0	1.7	-0.0	-0.9	-0.2	-0.6	-0.1
Back pain experienced in last month	0.5	0.7	2.5	1.6	0.6	0.4	0.7	0.9	-0.0
Breast cancer (self-reported)	0.5	0.6	1.7	0.0	0.5	0.9	1.3	0.7	0.2
Leg predicted mass (right)	0.5	2.6	4.6	0.7	2.1	1.4	1.8	1.1	2.1
Medication: Atorvastatin	0.5	0.7	3.0	-1.7	0.2	-0.9	-0.2	0.2	0.5
Leg fat percentage (left)	0.5	1.9	4.1	-0.9	-1.5	-0.9	-1.2	-1.4	-2.0
Bipolar Disorder or Schizophrenia	0.4	1.1	3.0	1.7	-1.1	-0.0	-0.6	-0.3	-1.4
HbA1C	0.4	0.5	2.0	1.4	-0.4	0.4	0.3	0.2	-0.8
Lupus	0.4	0.7	1.4	0.2	1.1	0.8	0.6	1.2	0.6
Relative age of first facial hair	0.4	0.8	3.4	-1.8	-0.5	-0.8	-0.2	-0.5	-0.2
Diabetes (father)	0.4	0.5	1.3	1.1	-0.0	0.7	1.0	0.5	0.1
Impedance of leg (right)	0.4	1.9	6.2	-2.5	-1.3	-0.8	-1.1	-0.6	-1.0
Leg fat-free mass (left)	0.4	1.9	3.7	0.5	1.9	1.1	1.4	0.8	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.2	1.2	-0.6	-1.5	0.3	-0.9	-0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.9	0.9	-1.0	0.1	0.1	-0.5	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	0.6	-0.7	-0.8	-0.6	-0.4	-0.7	-0.5
Leg predicted mass (left)	0.4	2.0	3.9	0.5	1.9	1.1	1.5	0.8	2.0
Qualifications: None of the above	0.4	0.8	3.2	1.8	0.9	0.2	0.8	0.4	0.3
Medication: Lansoprazole	0.4	0.5	0.9	0.6	0.3	1.0	0.4	0.9	0.6
Impedance of arm (left)	0.4	1.9	4.2	-0.1	0.9	2.0	1.2	2.0	0.9
Birth weight of first child	0.4	0.8	2.1	0.2	1.4	0.4	0.5	1.0	1.1
Migraine (self-reported)	0.4	0.5	1.2	-1.0	-1.1	-0.5	0.3	-0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	-1.1	-0.1	-0.6	-1.2	-0.0	0.1
Ever smoked	0.4	0.8	1.8	-1.4	-1.1	-0.4	-1.0	-0.6	-0.3
Alcohol drinker status: Previous	0.4	0.4	1.5	-1.2	-0.5	0.5	-0.2	0.4	-0.6
Worry (Nagel 2018)	0.3	0.6	3.0	-1.7	-0.2	-0.5	-0.6	-0.2	-0.0
Alzheimer’s Disease (in father)	0.3	0.3	0.9	-0.2	-0.5	-0.4	-0.9	-0.7	0.3
Rheumatoid Arthritis	0.3	0.5	2.5	1.6	-0.4	-0.1	0.0	0.2	-0.3
Tanning	0.3	4.2	12.5	3.5	1.7	1.3	1.2	1.6	2.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	-0.7	-0.8	-0.6	-0.8	-0.4	-0.7
Stomach or abdominal pain in last month	0.3	0.3	1.4	-0.5	0.1	-0.5	-0.1	-0.2	1.2
Impedance of leg (left)	0.3	1.3	5.3	-2.3	-1.0	-0.5	-0.6	-0.4	-0.9
Number of incorrect matches in round	0.3	0.5	1.9	1.4	0.8	0.8	0.1	0.1	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.9	0.4	0.8	0.1	0.4	-0.5
Forced vital capacity (FVC)	0.3	1.3	4.3	-0.5	1.6	-0.1	0.9	-0.0	2.1
Impedance of arm (right)	0.3	1.3	3.7	-0.5	0.5	1.7	0.8	1.9	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.9	-1.7	-0.5	-0.1	-0.6	-0.5	0.7
Lung cancer (father)	0.3	0.3	0.7	0.0	-0.5	-0.9	-0.6	-0.5	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.9	-0.1	0.1	0.9	0.5	0.5
Peak expiratory flow (PEF)	0.3	0.6	1.7	0.4	0.6	0.1	1.3	-0.1	1.2
Pulse wave reflection index	0.3	0.4	0.9	-0.5	0.2	0.7	1.0	0.7	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	0.9	0.5	-1.0	-0.6	-0.7	-0.8	-0.8
Worry too long after embarrassment	0.3	0.5	0.8	-0.9	-0.5	-0.7	-0.7	-0.8	0.1
Health satisfaction	0.3	0.4	2.0	0.1	-0.2	1.4	0.6	0.6	-0.0
Eye problems/disorders: None of the above	0.3	0.4	1.4	-1.2	-0.0	-0.1	-0.9	-0.1	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	0.9	0.0	-0.8	-0.8	-0.8	0.3
Alcohol intake frequency.	0.3	0.8	1.1	-0.9	-1.1	-0.5	-1.0	-1.0	-0.7
Suffer from ‘nerves’	0.3	0.5	1.3	-0.9	0.1	1.0	-0.0	1.1	0.4
Age at last live birth	0.3	0.4	0.7	0.5	-0.4	-0.8	-0.8	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.5	-0.0	-0.7	-0.4	-0.6	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	-0.6	-0.6	0.5	0.8	-0.0	-0.6
Medication: Gliclazide	0.3	0.3	1.1	-0.6	-0.6	0.2	-0.0	-0.0	-1.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.5	-0.7	-0.6	-1.0	-0.7	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	2.0	0.2	0.8	0.1	0.3	-0.7	1.4
Miserableness	0.3	0.5	1.3	0.4	-0.8	-0.8	-1.2	-0.7	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.1	0.6	0.7	1.0	0.5	0.6
Number of operations (self-reported)	0.3	0.4	1.3	0.4	-0.6	1.1	0.3	0.5	-0.5
Fractured/broken bones in last 5 years	0.3	0.3	1.4	-0.2	-0.1	1.2	0.4	0.7	-0.0
Unable to work because of sickness or disability	0.3	0.4	1.1	0.9	-0.1	1.0	0.7	0.3	0.2
Supplements: Calcium	0.3	0.3	0.7	0.6	0.3	0.9	0.5	0.7	-0.1
Heart disease (siblings)	0.3	0.3	0.8	-0.6	0.9	0.1	0.6	0.1	0.6
Schizophrenia (2018)	0.2	0.5	1.9	1.4	-0.6	0.5	-0.1	-0.0	-0.7
Crohns Disease (2017)	0.2	0.4	1.7	-1.3	-0.3	-0.1	-0.5	-0.5	-0.1
Ovarian Cancer	0.2	0.3	0.7	0.4	-0.5	-0.5	-0.8	-0.3	-0.6
Prostate Cancer	0.2	0.3	1.0	-0.2	-0.2	-1.0	-0.3	-0.7	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.6	-0.8	0.4	0.7	-0.2	0.5	-0.3
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.9	0.0	0.7	0.0	0.6	0.6
Heel T-Score	0.2	1.8	5.9	1.5	0.9	-0.6	2.4	1.0	0.7
Waist Hip Ratio (WHR)	0.2	0.8	2.7	-0.9	0.2	1.0	0.3	1.6	0.2
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.7	0.7	1.1	0.4	0.8	0.4
Lung FEV1/FVC ratio	0.2	1.0	3.0	0.3	1.2	0.2	1.1	0.7	1.7
Hand grip strength (left)	0.2	0.5	1.4	-1.2	0.8	0.1	0.5	-0.2	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.6	-0.2	0.8	0.5	0.7	0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.4	0.2	0.4	0.7	0.4	-0.1
Vitamin and mineral supplements	0.2	0.3	0.5	-0.5	-0.3	-0.4	-0.7	0.4	-0.7
Medication: Co-codamol	0.2	0.2	1.1	1.1	0.1	0.3	0.2	-0.3	-0.0
Medication: Metformin	0.2	0.2	0.4	-0.2	-0.6	0.5	0.4	0.4	-0.7
Hand grip strength (right)	0.2	0.4	1.2	-1.1	0.6	-0.6	0.2	-0.6	0.4
Townsend deprivation index at recruitment	0.2	0.3	1.1	0.4	0.2	1.1	0.4	0.7	0.2
Relative age voice broke	0.2	0.3	0.8	-0.1	0.6	-0.1	0.9	0.5	0.3
Nervous feelings	0.2	0.4	2.2	-1.5	0.1	0.4	-0.0	0.5	0.3
Mouth/teeth dental problems	0.2	0.2	0.6	0.1	-0.4	-0.6	0.1	-0.5	-0.8
Pain all over the body in last month	0.2	0.2	0.8	-0.6	0.0	0.9	0.3	0.4	-0.2
Neuroticism score	0.2	0.3	0.7	-0.8	-0.7	-0.4	-0.7	-0.2	-0.2
Hip circumference	0.2	0.7	1.4	-0.0	0.9	1.2	0.9	0.6	0.9
Worrier / anxious feelings	0.2	0.4	1.0	-1.0	-0.4	-0.8	-0.6	-0.7	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.2	-0.6	-0.7	-0.3	-0.7	-0.6
Number of live births	0.2	0.3	1.0	-0.3	-1.0	-0.2	-0.7	-0.1	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	-0.9	-0.2	-0.5	-0.7	-0.3	0.1
Medication: Cholesterol lowering	0.2	0.4	1.4	-1.2	0.1	0.3	-0.5	0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.9	-0.2	-0.1	-0.6	-0.3	-0.1
Birth weight	0.2	0.5	1.0	-0.1	0.8	0.9	0.5	0.3	1.0
Arm fat-free mass (right)	0.2	1.0	2.6	-0.3	1.5	-0.1	1.0	-0.3	1.6
Number of full brothers	0.2	0.3	0.7	-0.9	-0.0	0.4	-0.7	0.2	-0.7
Pulse wave peak to peak time	0.2	0.2	0.5	0.7	0.4	-0.0	-0.7	-0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.3	1.1	-0.1	0.2	0.3	-0.3	-0.4
Arm predicted mass (right)	0.2	1.1	2.7	-0.4	1.6	-0.0	1.0	-0.1	1.6
Pulse rate, automated reading	0.2	0.7	1.6	-1.3	-0.9	0.1	-0.3	0.9	-0.9
Overall health rating	0.2	0.3	1.1	-0.2	0.1	1.0	0.4	0.8	0.3
Whole body fat-free mass	0.2	1.2	3.2	-0.1	1.6	0.4	1.0	0.2	1.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.4	-0.2	-0.2	-0.7	-0.6	-0.5
Diabetes diagnosed by doctor	0.2	0.3	1.2	-0.4	-0.4	0.3	0.1	0.5	-1.1
Friendships satisfaction	0.2	0.2	1.1	1.1	0.2	0.4	-0.1	0.1	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.3	0.4	0.5	0.5	0.5	0.7
Whole body water mass	0.2	1.2	3.3	-0.2	1.7	0.4	1.0	0.2	1.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.8	-0.5	-0.1	-0.8	-0.2	-0.2
Mother’s age at death	0.2	0.2	0.5	-0.2	0.5	-0.2	0.6	-0.1	0.7
Basal metabolic rate	0.2	1.0	2.4	-0.2	1.5	0.4	0.9	0.2	1.6
Diastolic blood pressure, automated reading	0.2	0.6	2.6	-1.6	-0.5	0.6	-0.1	0.1	-0.6
Commuting to job workplace: Cycle	0.2	0.3	0.8	-0.1	0.1	0.9	0.7	0.6	0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	0.8	0.0	-0.4	-0.9	-0.2	0.0
Depression (Nagel 2018)	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.5	-0.4	-0.1
Breast Cancer	0.1	0.3	0.8	0.6	0.1	-0.6	-0.4	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.1	0.2	0.7	0.8	-0.1	-0.0	-0.7	-0.3	-0.0
Crohns Disease (2012)	0.1	0.2	0.6	-0.4	-0.4	-0.3	-0.8	-0.4	-0.6
Blood Red Count	0.1	1.1	4.0	-2.0	-0.3	0.8	0.3	0.5	-1.2
Blood White Count	0.1	0.9	3.1	1.8	0.7	0.8	0.7	0.7	0.6
Lung FVC	0.1	0.6	1.2	-0.0	0.7	-1.1	-0.4	-1.1	0.9
Neuroticism	0.1	0.3	0.9	-0.2	-0.5	-0.4	-0.9	-0.6	0.1
Hair Pigment	0.1	2.1	10.8	-3.3	-0.2	0.9	-0.2	0.8	-0.6
Average weekly spirits intake	0.1	0.1	0.3	0.0	-0.1	0.5	0.3	-0.3	0.5
Trunk fat percentage	0.1	0.5	1.2	-0.6	0.4	1.1	0.7	0.7	-0.0
Fed-up feelings	0.1	0.1	0.5	0.1	0.4	0.1	0.1	0.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	0.7	0.3	0.3	0.2	0.3	0.2
Taking other prescription medications	0.1	0.1	0.4	-0.1	0.4	0.6	0.1	0.5	0.2
Age when periods started (menarche)	0.1	0.2	0.6	0.3	0.7	-0.3	-0.2	0.1	0.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	-0.1	0.3	0.4	-0.0	0.2
Multivitamins +/- minerals	0.1	0.1	0.4	-0.3	-0.2	-0.1	0.1	-0.6	0.4
Body mass index (BMI)	0.1	0.3	0.8	0.4	-0.6	-0.0	-0.4	-0.6	-0.9
Trunk fat mass	0.1	0.5	0.8	-0.7	0.7	0.9	0.8	0.6	0.4
Waist circumference	0.1	0.4	1.2	-0.3	0.2	1.1	0.3	0.9	0.0
Past tobacco smoking	0.1	0.2	0.9	-0.1	0.5	0.1	1.0	0.2	0.1
Had menopause	0.1	0.1	0.4	-0.2	-0.5	0.0	-0.3	0.0	-0.6
Heart attack	0.1	0.1	0.3	-0.6	0.1	-0.6	-0.2	-0.1	0.1
Diabetes (self-reported)	0.1	0.2	0.4	-0.6	0.0	-0.2	0.2	0.4	-0.7
Weight	0.1	0.6	1.0	-0.5	1.0	0.7	0.8	0.4	0.9
Arm fat percentage (right)	0.1	0.3	1.2	-0.0	-0.6	0.4	-0.4	0.0	-1.1
Trunk fat-free mass	0.1	0.9	2.7	-0.5	1.4	-0.2	0.5	-0.3	1.6
Pulse rate	0.1	0.2	0.5	0.2	-0.7	-0.1	0.1	0.4	-0.5
Trunk predicted mass	0.1	0.8	2.4	-0.4	1.3	-0.3	0.4	-0.4	1.6
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	-0.0	0.5	-0.4	0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.8	0.9	0.4	0.1	0.2	0.0	0.3
Medication: Paracetamol	0.1	0.2	0.9	-0.1	-0.0	0.0	0.9	-0.2	-0.3
Headache pain in last month	0.1	0.1	0.3	-0.6	-0.2	0.0	0.5	0.2	0.2
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.1	-0.4	0.5	0.1	-0.1	-0.4
Medication: Blood pressure	0.1	0.2	0.3	-0.3	0.5	-0.0	0.5	0.5	0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.1	-0.0	-0.0	0.4	-0.0	-0.5
Leg fat mass (right)	0.1	0.2	0.5	-0.6	-0.4	-0.2	-0.4	-0.7	-0.5
Number of full sisters	0.1	0.1	0.3	0.3	-0.1	0.5	0.4	0.5	-0.2
Had major operations	0.1	0.2	0.4	-0.3	-0.6	0.4	0.5	0.1	-0.1
Family relationship satisfaction	0.1	0.1	0.3	0.5	-0.1	0.1	0.2	0.5	-0.3
Arm fat percentage (left)	0.1	0.2	0.6	0.3	-0.3	0.7	0.0	0.2	-0.8
Mood swings	0.1	0.2	1.0	1.0	-0.3	0.1	-0.5	-0.0	-0.1
Mineral and other dietary supplements	0.1	0.2	0.4	0.2	0.5	0.2	0.5	0.7	-0.1
Guilty feelings	0.1	0.2	0.7	-0.3	-0.1	-0.8	-0.1	-0.5	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.5	-0.4	-0.7	-0.3	-0.1	-0.3	-0.1
Medication: Paracetamol	0.1	0.2	0.8	-0.9	0.2	-0.3	0.6	-0.2	0.0
Alcohol drinker status: Never	0.1	0.2	0.8	0.9	0.2	0.2	0.3	0.0	0.3
Arm fat-free mass (left)	0.1	0.7	1.6	-0.6	1.2	-0.1	0.7	-0.3	1.3
Myopia	0.1	0.1	0.5	0.7	0.1	0.3	0.4	-0.1	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.3	-0.5	0.2	-0.4	-0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	0.1	-0.4	-0.2	-0.1	0.2
Impedance of whole body	0.1	0.6	1.8	-1.4	0.0	0.8	0.4	1.0	0.1
Arm predicted mass (left)	0.1	0.5	1.1	-0.7	1.0	-0.1	0.5	-0.3	1.0
Neuroticism (Nagel 2018)	0.0	0.1	0.3	-0.0	0.3	-0.2	-0.6	0.1	0.3
BMI	0.0	0.1	0.3	0.4	-0.1	0.3	-0.6	-0.3	-0.4
Supplements: Glucosamine	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.2	0.1
Arm fat mass (right)	0.0	0.1	0.2	-0.1	0.1	0.5	0.1	0.0	-0.3
Body fat percentage	0.0	0.2	0.6	-0.7	-0.2	0.4	0.0	0.0	-0.7
Qualifications: College or University degree	0.0	0.1	0.3	-0.5	-0.3	0.3	0.1	-0.3	0.6
Whole body fat mass	0.0	0.1	0.3	-0.4	0.3	0.5	0.4	0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.2	0.2	0.1	0.1	0.2	0.1
Arm fat mass (left)	0.0	0.1	0.5	0.0	0.3	0.7	0.4	0.2	0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.3	-0.2
Leg fat mass (left)	0.0	0.2	0.4	-0.4	-0.3	-0.1	-0.2	-0.6	-0.5

Hub : Genes

ZNF683

Models

Trait associations