Hub : Genes

PTAFR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.4930	0.1190	4.5e-05	0.099	NA	0.065	NA	0.170	7.6e-04	NA	5.7e-03	NA	1.0e-05
2	GTEx	Skin Not Sun Exposed Suprapubic	0.2280	0.0870	4.3e-03	0.136	NA	0.081	NA	0.101	6.5e-08	NA	3.2e-05	NA	3.7e-06
3	GTEx	Skin Sun Exposed Lower leg	0.2650	0.0730	3.9e-04	0.135	NA	0.107	NA	0.118	3.1e-11	NA	3.5e-09	NA	5.9e-10
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0366	0.0203	2.5e-03	0.023	0.010	0.015	NA	0.017	1.2e-03	0.02400	7.4e-03	NA	4.2e-03
5	TCGA	Lung Squamous Cell Carcinoma	0.0710	0.0333	1.9e-03	0.037	0.000	0.015	NA	0.029	4.4e-05	0.37000	7.7e-03	NA	2.6e-04
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.1350	0.0670	8.7e-04	0.033	0.047	0.017	NA	0.027	2.4e-03	0.00041	2.2e-02	NA	5.6e-03
7	TCGA	Thyroid Carcinoma	0.0730	0.0370	2.1e-03	0.022	0.018	0.018	NA	0.021	2.9e-03	0.00610	6.5e-03	NA	3.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.2	2.2	0.2	1.2	1.3	0.0	1.5	1.1	1.3
Bipolar Disorder or Schizophrenia	1.6	3.9	6.0	-2.4	2.0	1.8	0.0	2.4	1.9	2.3
Depressed Affect (Nagel 2018)	0.3	0.7	3.4	-1.8	0.2	0.1	0.5	0.0	1.1	0.4
Depression (Nagel 2018)	0.4	0.6	1.7	-1.0	-0.5	-0.5	-0.7	-0.7	0.2	-1.3
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.4	-0.3	-1.1	-1.2	-0.9	-0.7	-0.7	1.0
Neuroticism (Nagel 2018)	0.5	1.3	6.1	-2.5	-0.2	-0.3	0.1	-0.3	1.4	-0.8
Schizophrenia (2018)	1.5	3.1	5.5	-2.3	1.6	1.3	0.9	1.9	2.0	1.8
Schizophrenia vs Biploar Disorder	0.7	1.0	3.8	-1.9	-0.8	-1.0	0.0	-0.5	0.3	0.9
Worry (Nagel 2018)	0.6	1.3	6.6	-2.6	0.2	-0.1	0.2	0.0	1.5	-0.5
Alzheimer’s Disease (in mother)	0.3	0.3	1.3	1.1	0.4	0.4	0.4	0.7	0.0	0.5
Alzheimer’s Disease (in father)	1.0	1.1	1.9	1.1	-1.4	-1.2	-1.1	-1.4	-0.3	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	2.1	1.5	-0.5	-0.4	-0.6	-0.4	-0.1	0.5
Crohns Disease (2017)	0.5	1.2	5.8	0.1	0.2	0.3	-0.1	0.4	-1.5	-2.4
Irritable Bowel Disease (IBD)	0.8	1.9	4.2	0.2	1.8	1.9	1.2	2.1	0.6	-0.6
Ulcerative Colitis (UC)	2.1	4.0	7.2	-0.1	2.5	2.5	1.8	2.7	2.1	1.0
Major Depression (MDD)	0.0	0.1	0.2	-0.0	-0.2	-0.1	0.0	0.2	0.4	0.3
Reaction Time	0.9	1.6	10.4	3.2	0.3	0.8	0.3	0.2	0.4	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	4.1	-0.4	0.2	0.1	0.8	0.5	0.1	2.0
Breast Cancer	0.4	0.9	1.7	-1.3	0.8	0.7	1.1	1.1	0.4	0.8
Ovarian Cancer	0.3	0.4	1.7	-0.6	-0.1	-0.3	-0.6	-0.1	0.2	-1.3
Prostate Cancer	1.7	2.3	5.1	1.5	-1.3	-1.0	-1.1	-1.5	-1.7	-2.3
Age at First Birth	0.1	0.1	0.2	0.3	0.1	0.4	0.3	0.3	0.2	-0.4
Bipolar Disorder (2011)	1.3	1.2	2.9	-0.4	1.7	1.7	0.0	1.7	0.0	0.0
Body Mass Index (BMI) (2010)	3.5	4.8	7.0	1.1	-2.6	-2.4	-2.2	-2.5	-2.6	-1.2
Coronary Artery Disease (CAD)	0.5	0.5	1.3	0.5	-0.8	-0.8	0.0	-0.9	0.3	1.2
Crohns Disease (2012)	0.4	0.6	1.7	-0.6	0.9	0.9	0.0	1.3	-0.6	-0.5
Mean Putamen Volume	0.5	0.6	1.4	-1.2	-0.8	-0.8	-0.5	-0.8	-0.2	-0.8
Fasting Glucose	0.5	0.5	1.6	0.9	0.2	0.3	0.3	0.5	1.0	1.3
HbA1C	1.0	1.1	2.0	1.1	1.1	1.2	1.2	1.4	0.4	0.4
HDL Cholesterol	0.6	0.9	3.3	-1.6	0.4	0.4	0.4	0.3	0.4	-1.8
LDL Cholesterol	1.8	2.8	5.4	2.3	-1.6	-1.3	-1.8	-1.4	-1.7	-1.5
Lupus	0.3	0.4	2.0	-1.4	-0.3	-0.4	0.0	0.1	0.3	0.9
Neuroticism (2016)	0.2	0.3	0.7	0.0	-0.4	-0.6	-0.4	-0.2	0.9	-0.7
Primary Biliary Cirrhosis	0.8	1.2	2.5	-0.8	1.6	1.5	1.3	1.1	0.3	0.1
Rheumatoid Arthritis	0.2	0.2	0.8	0.9	0.4	0.6	0.5	0.4	-0.1	0.0
Schizophrenia (2014)	1.5	3.2	8.3	-2.1	1.5	1.2	0.0	1.8	1.8	2.9
Triglycerides	0.7	1.1	1.7	0.5	-1.2	-1.1	-1.2	-1.3	-0.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.1	-0.2	-0.5	0.0	-0.2	-0.1	0.4
Ulcerative Colitis	1.9	2.7	5.1	0.5	2.3	2.2	0.0	2.2	1.1	1.7
Blood Eosinophil Count	1.6	12.4	56.7	-1.2	1.6	1.2	3.0	2.7	2.8	7.5
Blood Platelet Count	0.1	1.4	2.2	-0.9	1.1	1.1	1.5	1.5	-0.5	-1.2
Blood Red Count	0.4	3.7	14.1	-0.0	1.3	1.4	2.4	1.1	1.1	3.8
Blood White Count	0.2	1.7	3.3	-1.3	1.1	0.7	1.5	1.4	1.1	1.8
Heel T-Score	0.1	1.0	4.0	0.6	-0.9	-0.6	-0.6	-0.7	0.5	2.0
BMI	0.7	4.1	5.6	2.4	-2.2	-1.9	-2.2	-2.2	-2.3	-0.3
Height	0.1	1.2	7.0	-0.4	-0.0	0.1	0.3	0.1	-1.1	-2.6
Waist Hip Ratio (WHR)	0.7	3.2	5.7	-0.7	-1.8	-2.0	-2.4	-2.0	-0.9	-2.0
Systolic Blood Pressure	0.5	2.4	5.6	0.0	1.3	1.3	2.0	1.6	1.1	2.4
Smoking Status	0.1	0.3	1.3	0.8	0.3	0.1	-0.4	-0.0	-0.3	-1.2
Allergy or Eczema	2.7	7.2	14.8	-0.4	3.8	3.9	3.2	3.2	0.7	-0.4
Cardiovascular Disease	0.7	2.2	4.5	-1.2	-2.1	-2.1	-1.3	-1.5	-1.1	-0.0
Hypothyroidism (self reported)	3.1	7.2	13.2	-1.8	2.5	2.3	2.7	2.6	3.6	2.9
Respiratory disease	2.9	6.4	12.8	0.4	3.5	3.6	2.5	3.4	1.3	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.0	-1.4	-0.3	-0.4	0.1	-0.4	-0.2	0.3
Lung FEV1/FVC ratio	0.2	1.0	3.5	1.9	-0.8	-0.7	-0.2	-1.0	-1.1	0.1
Lung FVC	0.0	0.1	0.2	0.4	0.1	0.3	-0.0	0.1	-0.3	-0.5
Neuroticism	0.5	1.3	6.0	-2.4	-0.1	-0.4	-0.1	-0.3	1.4	-0.9
Chronotype (morning person)	0.1	0.3	0.9	-0.4	-0.6	-0.6	-0.3	-0.1	-1.0	-0.5
Hair Pigment	0.1	1.6	3.0	-0.2	1.6	1.7	1.5	1.7	0.1	-0.7
Tanning	0.1	0.9	2.3	-0.5	-0.8	-0.7	-0.9	-1.0	-1.5	-0.9
Hand grip strength (left)	0.6	1.6	3.0	-0.9	1.6	1.7	0.9	1.7	-0.0	-1.1
Number of treatments/medications taken	0.3	0.5	1.6	0.4	0.3	0.1	0.2	0.6	1.2	1.1
Average weekly spirits intake	0.1	0.2	0.9	1.0	-0.1	-0.0	0.2	0.0	-0.4	-0.0
Sensitivity / hurt feelings	1.3	2.3	4.3	1.1	-1.5	-1.5	-1.7	-1.5	-0.9	-2.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.5	-1.6	0.6	0.6	0.2	0.6	0.5	-0.6
Hearing difficulty/problems: Yes	0.5	0.7	1.7	0.8	-0.9	-0.8	-1.3	-0.7	-0.4	-0.8
Relative age of first facial hair	0.1	0.2	0.8	0.4	0.3	0.3	0.2	-0.0	0.9	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	0.6	-0.0	0.2	-0.2	-0.0	-0.3	0.3
Ever used hormone-replacement therapy (HRT)	1.1	1.3	3.3	1.0	1.3	1.2	0.4	0.9	1.8	1.0
Ever had hysterectomy (womb removed)	1.7	1.9	3.3	0.5	-1.7	-1.8	-1.8	-1.6	-1.1	-0.5
Systolic blood pressure, automated reading	0.1	0.3	0.8	0.8	0.4	0.4	0.4	0.4	0.2	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.8	0.3	0.3	0.8	0.3	0.8	0.1
Angina	0.2	0.3	1.1	1.1	0.2	0.3	-0.0	0.5	0.4	0.6
Medication for hormone replacement therapy	0.5	0.6	1.3	0.9	0.9	1.0	-0.0	1.1	-0.5	0.1
Vitamin and mineral supplements	0.3	0.4	2.1	-0.9	0.1	0.3	0.3	0.2	-1.4	-0.0
Supplements: Zinc	0.6	0.7	2.0	-1.4	-0.0	-0.1	-0.2	0.2	0.8	-1.4
Medication: Co-codamol	0.5	0.5	2.4	1.6	0.4	0.6	0.3	0.6	-0.0	-0.7
Medication: Metformin	0.4	0.6	1.6	-1.2	0.0	0.0	0.3	0.2	1.3	0.8
Diabetes (father)	0.9	1.1	3.5	0.6	-1.1	-1.0	-1.9	-0.6	-0.2	-1.2
Diabetes (mother)	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.2	0.1	0.7	0.2
Severe depression (siblings)	0.9	1.0	3.6	1.4	-0.6	-0.8	-1.9	-0.6	0.4	0.1
Pack years adult smoking proportion	0.1	0.2	0.4	-0.3	0.3	0.3	0.5	0.2	-0.4	-0.6
Impedance of leg (right)	0.1	0.5	1.1	0.4	0.9	0.9	0.3	1.1	0.3	-0.4
Leg fat-free mass (left)	0.4	1.9	3.4	0.0	-1.8	-1.6	-1.1	-1.8	-1.3	-1.1
Trunk fat percentage	0.5	1.9	3.6	1.9	-1.6	-1.5	-1.4	-1.4	-0.2	1.0
Hand grip strength (right)	0.3	0.9	1.7	-1.1	0.9	1.0	0.6	1.0	-0.6	-1.3
Townsend deprivation index at recruitment	0.2	0.3	1.3	-1.2	0.3	0.0	-0.2	0.2	0.3	0.5
Current tobacco smoking	0.9	1.5	3.2	0.6	1.8	1.6	0.6	1.5	1.2	-0.2
Average weekly fortified wine intake	1.1	1.2	3.0	0.9	1.1	1.2	1.2	0.8	-1.7	-0.2
Maternal smoking around birth	1.3	1.9	8.2	0.2	-0.9	-0.7	-1.5	-0.7	-1.1	-2.9
Fed-up feelings	0.1	0.2	0.5	-0.6	0.2	0.2	-0.2	0.1	0.4	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.5	-0.9	-0.1	-0.0	-0.8	-0.1	0.4	-1.2
Relative age voice broke	0.2	0.3	0.9	-0.7	-0.2	-0.3	-0.5	-0.4	0.4	-0.9
Taking other prescription medications	0.1	0.1	0.4	-0.0	-0.2	-0.3	-0.4	0.1	0.7	0.0
Age when periods started (menarche)	0.1	0.2	0.9	-0.7	-0.2	-0.3	-0.4	-0.1	0.4	-0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.8	0.3	-0.7	-1.0	-1.2	-0.9	0.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.8	-1.5	1.4	1.3	1.7	1.2	1.4	0.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.6	0.8	-1.0	-1.0	-1.3	-1.1	-1.1	0.2
Qualifications: CSEs or equivalent	1.2	1.6	3.6	0.0	-1.0	-0.9	-1.9	-1.3	-0.9	-1.8
Serious illness, injury or assault to yourself	1.8	2.2	3.6	1.1	-1.5	-1.3	-1.6	-1.6	-1.2	-1.9
High blood pressure	0.5	1.3	2.3	-1.5	-1.4	-1.4	-0.6	-1.1	-1.0	0.1
Hayfever, allergic rhinitis or eczema	2.4	5.3	11.6	-0.4	3.2	3.4	2.5	2.5	1.1	-1.3
Multivitamins +/- minerals	0.2	0.3	1.9	-0.3	0.3	0.1	0.0	0.2	1.4	0.0
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.1	-0.9	-0.8	-1.1	-0.8	0.2	0.2
Supplements: Glucosamine	1.8	2.4	3.4	1.1	-1.8	-1.8	-1.7	-1.8	-1.0	-1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.9	-0.2	0.3	0.4	0.6	0.6	1.4	1.2
Medication: Atenolol	0.2	0.3	1.6	-1.2	0.2	0.0	0.2	0.4	0.4	0.1
Medication: Levothyroxine sodium	3.0	5.2	9.7	-1.9	2.3	2.0	2.1	2.1	3.1	2.2
Sitting height	0.3	2.4	7.3	-2.7	1.2	1.1	1.9	1.4	0.6	0.9
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	-0.8	0.3	0.3	-0.2	0.4	-0.0	-0.1
High blood pressure (mother)	1.4	2.0	3.3	-0.7	1.8	1.7	1.6	1.7	1.4	-0.2
Body mass index (BMI)	0.7	2.8	4.2	1.7	-2.0	-1.9	-1.9	-2.0	-1.1	0.2
Impedance of leg (left)	0.3	1.4	3.3	0.2	1.6	1.5	0.9	1.8	0.8	0.1
Leg predicted mass (left)	0.3	1.8	3.3	-0.1	-1.8	-1.6	-1.1	-1.7	-1.3	-1.1
Trunk fat mass	0.4	1.8	2.9	1.6	-1.7	-1.6	-1.5	-1.5	-0.5	0.3
Waist circumference	0.9	3.1	4.6	1.5	-2.1	-2.1	-2.1	-2.1	-1.1	-0.7
Number of incorrect matches in round	0.8	1.3	2.4	0.8	1.4	1.6	1.3	1.1	0.7	0.9
Past tobacco smoking	0.5	0.9	1.7	-0.3	1.0	1.3	1.1	1.2	-0.3	0.7
Alcohol usually taken with meals	0.2	0.3	1.4	0.5	-0.4	-0.3	-0.1	-0.2	-1.2	0.2
Nervous feelings	0.3	0.6	1.6	-1.3	0.5	0.3	1.0	0.3	1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.5	-1.6	0.5	0.4	0.7	0.6	0.7	-0.0
Hearing difficulty/problems with background noise	0.9	1.4	2.7	-0.7	-1.4	-1.6	-1.5	-1.2	0.8	0.5
Hair/balding pattern: Pattern 2	0.6	0.8	1.7	-0.5	1.1	1.3	0.6	1.0	0.4	-0.9
Had menopause	1.1	1.3	2.8	-0.6	1.2	0.9	1.1	1.1	1.7	1.2
Had other major operations	5.0	6.1	10.3	0.5	-3.0	-3.0	-3.2	-2.8	-1.5	-2.0
Forced vital capacity (FVC)	0.2	0.9	3.0	-1.7	0.6	0.6	0.6	0.5	-0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	5.1	-1.8	2.2	2.0	2.2	2.0	2.3	1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	4.2	2.0	-0.2	-0.1	-1.1	-0.5	0.1	-0.7
Qualifications: None of the above	0.1	0.3	0.6	0.4	0.4	0.4	0.4	0.6	0.6	0.8
Financial difficulties in last 2 years	0.4	0.5	1.3	-0.5	-0.1	-0.4	-0.8	-0.2	1.2	1.0
Mouth/teeth dental problems	0.5	0.8	2.5	-0.1	-0.7	-0.6	-0.6	-0.5	-1.3	-1.6
Heart attack	0.2	0.3	0.9	-0.4	0.0	0.0	0.6	0.6	0.4	1.0
Allergy	2.1	4.9	10.7	-0.0	-3.1	-3.3	-2.4	-2.5	-1.3	0.9
Pain all over the body in last month	2.0	2.2	5.1	-0.7	1.5	1.6	0.9	1.5	2.2	1.5
Diabetes (self-reported)	0.7	1.0	1.9	-0.7	-1.3	-1.3	-0.7	-1.4	0.0	-0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	-0.3	1.1	1.1	1.0	1.0	0.0	-1.3
Medication: Ramipril	0.2	0.2	0.7	0.9	-0.3	-0.2	0.5	-0.1	-0.5	0.0
Medication: Simvastatin	0.6	0.8	1.8	0.6	-1.4	-1.3	-1.1	-0.9	0.2	-0.1
Fluid intelligence score	0.3	0.7	1.6	-0.7	0.6	0.5	1.0	1.0	0.1	1.2
Illnesses of siblings	0.4	0.5	1.7	-1.3	0.5	0.6	0.1	0.7	-0.1	-1.0
Neuroticism score	0.6	1.2	4.3	-2.1	-0.4	-0.7	-0.6	-0.5	0.9	-1.4
Weight	0.3	1.5	2.5	1.2	-1.6	-1.4	-1.2	-1.4	-0.9	-0.5
Impedance of arm (right)	0.2	0.9	1.3	0.6	1.1	1.0	0.8	1.1	0.9	0.8
Arm fat percentage (right)	0.8	3.3	6.4	2.5	-2.1	-1.9	-2.0	-1.9	-0.7	0.4
Trunk fat-free mass	0.1	0.5	2.0	-0.7	-0.5	-0.3	-0.1	-0.3	-0.8	-1.4
Hip circumference	0.1	0.6	2.0	1.4	-0.7	-0.6	-0.3	-0.6	-0.3	0.9
Time employed in main current job	0.5	0.5	0.8	0.6	0.8	0.8	0.8	0.9	0.4	0.7
Alcohol intake versus 10 years previously	0.5	0.8	1.3	0.9	-1.0	-1.0	-1.0	-1.1	-0.4	0.4
Father’s age at death	1.3	1.8	3.4	0.9	-1.7	-1.4	-1.4	-1.8	-1.1	-0.6
Worrier / anxious feelings	0.4	0.8	3.1	-1.8	0.3	0.0	0.5	0.0	1.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	4.1	-0.3	-1.8	-2.0	-2.0	-1.7	-0.1	-1.0
Falls in the last year	0.7	1.0	2.0	-0.9	-0.9	-1.0	-0.5	-1.3	-0.3	-1.4
Hair/balding pattern: Pattern 3	4.5	6.6	9.3	-0.8	2.9	2.7	3.0	3.0	2.4	2.5
Number of live births	0.4	0.6	2.1	1.3	0.3	0.5	-0.1	0.2	-0.2	-1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.7	-0.8	0.0	0.2	0.3	0.0	-1.1	-1.3
Pulse rate	0.7	1.1	1.7	1.1	1.2	1.3	0.9	1.0	1.0	0.8
Happiness	1.0	1.2	2.8	-0.3	-0.9	-1.0	-1.6	-1.2	0.0	-1.7
Noisy workplace	2.5	3.1	14.2	3.8	1.3	1.6	0.5	1.2	0.4	1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	-1.1	0.9	0.9	1.2	0.8	0.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.5	-0.1	-0.3	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.8	0.4	0.4	0.2	0.3	0.3	0.6
Asthma	2.4	4.7	9.2	0.8	3.0	3.0	2.1	2.7	1.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.0	0.2	0.1	-0.3	0.4	-0.2	-0.4
Medication: Cholesterol lowering	0.3	0.4	1.0	0.7	-0.9	-1.0	-0.5	-0.6	0.1	-0.6
Depression (self-reported)	1.0	1.2	1.9	-0.3	-1.3	-1.4	-1.3	-1.4	-0.4	-0.9
Medication: Lansoprazole	1.2	1.4	2.3	-0.3	1.3	1.3	1.2	1.4	0.8	1.5
Prospective memory result	0.5	0.6	2.6	1.6	0.1	0.3	0.6	-0.6	-1.0	-0.3
Lung cancer (father)	0.4	0.4	2.2	1.5	-0.5	-0.3	-0.5	-0.2	-0.4	0.1
Illnesses of mother	4.9	6.0	10.5	0.3	-3.0	-2.8	-2.7	-3.2	-2.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.2	-0.2	0.6	0.8	1.1	0.5	-0.2	-0.0
Pulse wave Arterial Stiffness index	0.6	0.8	4.3	2.1	-0.2	0.0	0.1	-0.4	0.2	0.8
Impedance of arm (left)	0.1	0.4	0.8	0.2	0.6	0.5	0.6	0.6	0.9	0.9
Arm fat mass (right)	0.7	2.9	4.3	2.0	-2.1	-1.9	-1.9	-1.9	-1.0	0.1
Trunk predicted mass	0.1	0.6	2.3	-0.8	-0.5	-0.3	-0.0	-0.3	-0.9	-1.5
Standing height	0.1	1.4	2.1	-1.4	1.1	1.1	1.5	1.2	0.4	-1.3
Length of working week for main job	1.9	2.1	5.3	-2.3	1.0	0.7	0.6	1.5	1.8	1.3
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.6	0.1	0.2	-0.3	0.6	0.2	-0.0
Breastfed as a baby	0.1	0.1	0.4	-0.6	0.1	0.1	0.2	0.3	0.3	0.3
Tense / ‘highly strung’	0.6	1.0	3.6	-1.9	-0.4	-0.5	-0.8	-0.6	0.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.9	-1.2	-1.0	-1.2	-1.7	-1.2	0.6	-1.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.1	-0.1	-1.0	-1.0	-1.0	-0.9	-1.0	-0.0
Birth weight of first child	0.6	1.0	2.3	1.5	0.9	1.3	0.7	0.4	-0.6	-1.1
Peak expiratory flow (PEF)	0.2	0.5	1.7	-0.9	-0.4	-0.2	-0.0	-0.3	-1.3	-1.0
Pulse wave reflection index	0.8	1.0	2.1	0.4	-1.3	-1.4	-0.4	-1.4	-1.0	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.0	1.4	0.2	0.2	-0.3	0.1	-0.2	0.8
Loud music exposure frequency	0.3	0.3	0.9	0.4	-0.5	-0.4	-0.2	-0.5	-0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	6.7	-2.6	-0.7	-0.8	-0.8	-0.7	0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.6	0.2	1.0	1.0	1.1	1.2	0.7	2.1
Blood clot in the leg (DVT)	0.6	0.8	1.6	-0.4	-1.0	-1.3	-1.1	-1.0	0.7	-0.2
Medication: Paracetamol	0.3	0.4	1.3	0.4	0.6	0.7	1.1	0.8	0.0	0.1
Headache pain in last month	0.7	1.2	2.1	-1.5	-1.0	-1.1	-0.7	-1.1	-1.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	-0.4	1.4	1.4	0.9	1.0	0.1	0.0
Glaucoma (self-reported)	0.4	0.5	1.0	0.3	0.9	0.8	0.9	1.0	0.3	0.1
Gout (self-reported)	0.1	0.2	0.6	-0.0	0.4	0.7	0.8	0.3	0.0	-0.3
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	9.1	-1.4	2.5	2.3	2.5	2.6	3.0	2.6
Medication: Amlodipine	0.1	0.2	0.5	0.3	0.3	0.2	0.4	0.5	0.1	0.7
Medication: Ventolin 100micrograms inhaler	2.0	2.6	5.9	1.1	2.3	2.4	1.1	1.8	0.9	-0.9
Birth weight	1.8	4.0	6.3	-0.6	2.5	2.2	2.4	2.5	1.6	1.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.2	1.3	1.3	1.5	0.8	1.4	-0.2	0.4
High blood pressure (siblings)	1.0	1.4	6.5	1.6	0.5	0.4	0.6	0.4	0.3	2.6
Forced vital capacity (FVC), Best measure	0.2	0.8	1.5	-0.5	1.0	1.2	1.2	1.0	0.1	-0.5
Body fat percentage	0.7	2.6	4.3	2.1	-1.9	-1.8	-1.8	-1.7	-0.5	0.6
Leg fat percentage (right)	0.8	3.0	4.9	2.2	-2.0	-1.9	-2.1	-1.8	-1.1	-0.1
Arm fat-free mass (right)	0.2	1.0	2.0	-0.7	-1.1	-1.0	-0.5	-0.9	-0.9	-1.4
Exposure to tobacco smoke outside home	0.7	1.0	6.1	-0.2	0.1	0.1	-0.6	-0.4	0.1	-2.5
Comparative body size at age 10	0.3	0.7	3.6	-0.3	0.2	0.0	1.2	0.2	0.2	1.9
Number of full brothers	0.3	0.4	1.0	1.0	-0.6	-0.4	-0.5	-0.5	-0.8	-0.6
Worry too long after embarrassment	0.5	0.8	2.8	-0.7	-0.7	-0.9	-0.4	-0.9	-0.0	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.4	-0.9	-1.3	-1.3	-1.1	-1.2	-0.1	-1.6
Wheeze or whistling in the chest in last year	0.1	0.3	0.5	0.7	0.5	0.5	-0.5	0.4	0.4	-0.7
Number of children fathered	0.4	0.5	2.4	1.5	-0.2	-0.0	-0.6	-0.1	-0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.5	0.2	0.6	0.5	0.7	0.6	1.6	0.2
Age at first live birth	0.7	1.3	3.2	-1.0	1.2	1.3	1.8	1.0	0.8	0.5
Pulse wave peak to peak time	0.7	0.9	4.9	-2.2	0.3	0.1	-0.0	0.6	-0.2	-0.9
Health satisfaction	2.5	3.2	4.9	1.8	-2.2	-2.0	-2.0	-2.0	-1.1	-0.9
Shortness of breath walking on level ground	1.9	2.2	3.8	1.9	-1.6	-1.6	-2.0	-1.4	-1.0	0.1
Qualifications: College or University degree	1.1	3.3	7.5	-1.0	1.7	1.5	2.7	1.4	1.3	2.5
Eye problems/disorders: None of the above	1.1	1.3	1.9	0.3	-1.4	-1.4	-1.3	-1.3	-1.4	-0.1
Mouth/teeth dental problems: Loose teeth	2.9	3.5	5.7	0.3	2.4	2.3	2.3	2.4	0.8	1.4
Emphysema/chronic bronchitis	0.8	0.9	2.0	1.2	-0.7	-0.4	-1.2	-0.7	-0.5	-1.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.8	0.5	0.7	0.1	-0.0	-0.5	-0.6
Neck or shoulder pain in last month	1.2	1.7	6.0	0.8	-1.1	-0.9	-0.9	-1.0	-1.3	-2.5
Medication: Blood pressure	0.1	0.3	1.5	-0.0	-0.1	-0.2	0.3	0.2	0.5	1.2
Angina (self-reported)	0.3	0.4	1.3	1.1	0.1	0.2	-0.2	0.5	0.5	0.8
Migraine (self-reported)	0.4	0.5	1.1	0.1	-0.5	-0.5	-0.5	-0.7	-1.0	-1.1
Medication: Ibuprofen	0.0	0.1	0.2	0.0	0.3	0.2	-0.1	0.5	0.1	-0.1
Medication: Allopurinol	0.1	0.2	0.5	0.3	0.4	0.7	0.7	0.4	-0.2	0.1
Medication: Omeprazole	0.4	0.5	0.9	0.7	-0.5	-0.6	-0.9	-0.5	0.8	-0.4
Medication: Seretide 50 evohaler	1.3	1.5	4.3	0.3	-0.9	-0.9	-1.9	-1.1	0.2	-2.1
Mean time to correctly identify matches	1.1	2.1	12.9	3.6	-0.3	0.2	-0.3	-0.5	0.7	-0.8
Heart disease (mother)	0.9	1.1	1.8	-0.5	1.2	0.9	1.0	1.2	1.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.5	1.2	0.2	0.1	-0.2	0.0	-0.4	-0.8
Whole body fat mass	0.6	2.5	4.1	1.7	-2.0	-1.9	-1.7	-1.8	-0.9	0.2
Leg fat mass (right)	1.0	3.7	5.8	1.9	-2.4	-2.2	-2.1	-2.2	-1.5	-0.5
Arm predicted mass (right)	0.2	0.9	1.5	-0.8	-1.2	-1.1	-0.6	-1.0	-0.7	-1.2
Pulse rate, automated reading	0.8	2.6	5.1	0.9	-1.6	-1.3	-2.3	-1.6	-1.2	-2.0
Alcohol intake frequency.	0.5	1.2	3.0	0.2	1.2	1.0	1.7	1.3	-0.1	1.1
Comparative height size at age 10	0.3	1.7	2.5	-1.4	1.5	1.4	1.6	1.4	1.1	-0.5
Number of full sisters	1.1	1.3	2.8	-0.5	-1.2	-1.3	-1.7	-1.1	-1.0	0.8
Suffer from ‘nerves’	0.2	0.4	1.2	-1.0	-0.3	-0.4	-0.1	-0.3	0.3	-1.1
Overall health rating	1.1	2.4	5.8	-0.1	-1.8	-1.7	-2.4	-1.5	0.4	-1.5
Chest pain or discomfort	0.6	0.8	1.5	-0.2	-1.1	-1.1	-1.2	-0.7	-0.1	-1.2
Had major operations	1.3	1.5	2.8	-0.8	1.4	1.5	1.4	1.7	0.4	0.8
Age at last live birth	2.3	3.4	6.6	1.1	2.2	2.5	2.6	2.1	0.6	0.5
Family relationship satisfaction	0.6	0.8	1.9	0.4	-0.8	-0.9	-1.4	-0.8	-0.5	-1.0
Leg pain on walking	2.8	3.4	5.9	0.5	-2.3	-2.3	-2.4	-2.3	-1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.5	-0.1	-0.4	-0.2	-0.8	-0.3	-0.0	-1.2
Commuting to job workplace: Car/motor vehicle	4.9	5.6	14.5	2.1	-2.0	-1.6	-2.5	-2.2	-1.5	-3.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	4.8	-0.5	1.1	1.1	2.2	1.3	0.0	1.3
Medication: Aspirin	0.3	0.4	0.8	-0.3	-0.6	-0.8	-0.4	-0.3	0.6	0.9
Supplements: Vitamin C	0.4	0.5	1.2	0.3	0.5	0.6	0.9	0.5	1.1	-0.6
Knee pain experienced in last month	0.2	0.3	0.7	-0.5	-0.8	-0.7	-0.5	-0.7	-0.1	-0.0
Hypertension (Self-reported)	0.5	1.5	2.8	-1.3	-1.7	-1.6	-0.9	-1.3	-0.9	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.5	-1.2	-0.5	-0.8	-0.7	-0.3	0.5	0.5
Illnesses of father: Heart disease	5.8	8.0	12.6	0.1	3.4	3.6	2.9	3.2	2.8	2.3
Illnesses of siblings: Diabetes	0.7	0.9	1.6	0.6	-1.1	-1.3	-0.8	-1.1	-1.0	-0.4
Smoking status: Previous	1.2	1.8	3.5	-0.5	-1.6	-1.9	-1.2	-1.8	-0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-0.2	1.0	1.1	1.3	1.2	-0.0	-0.7
Whole body fat-free mass	0.2	0.9	1.8	-0.5	-1.1	-0.8	-0.5	-0.9	-1.0	-1.3
Leg fat-free mass (right)	0.2	1.2	2.2	-0.1	-1.5	-1.3	-0.7	-1.4	-1.1	-1.0
Arm fat percentage (left)	0.9	3.8	6.0	2.2	-2.4	-2.3	-2.2	-2.2	-0.8	0.4
Average weekly red wine intake	1.1	1.6	2.7	-0.4	1.2	1.1	1.5	1.6	1.0	1.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	-0.1	-0.5	-0.5	-1.0	-0.7	-0.4	-0.1
Mood swings	0.2	0.4	1.7	0.1	-0.3	-0.3	-0.6	-0.5	-0.3	-1.3
Loneliness, isolation	2.3	3.1	7.1	-1.6	1.6	1.3	1.2	1.4	2.7	2.2
Long-standing illness, disability or infirmity	0.9	1.3	2.5	-0.3	-1.3	-1.3	-1.2	-1.1	-0.6	-1.6
Ever had bowel cancer screening	0.7	0.8	1.2	1.0	-0.9	-1.0	-1.0	-1.1	0.2	-0.6
Diabetes diagnosed by doctor	0.5	0.8	3.0	-1.7	-0.9	-0.8	-0.3	-1.0	-0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.8	-1.7	-0.6	-0.5	-0.2	-0.4	0.9	-0.1
Friendships satisfaction	0.1	0.1	0.3	-0.2	-0.2	-0.4	-0.2	-0.3	-0.5	-0.1
Qualifications: nursing, teaching	0.7	1.0	2.3	-0.1	1.4	1.3	1.5	0.9	0.5	-0.0
Commuting to job workplace: Walk	1.2	1.3	6.2	-0.3	0.3	0.3	-0.1	0.5	1.5	2.5
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.1	0.4	0.4	0.5	0.4	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-0.8	0.3	0.3	0.2	0.0	1.2	1.0
Medication for cholesterol	0.1	0.2	0.9	0.9	0.4	0.3	0.6	-0.0	-0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	5.7	0.9	-1.9	-1.6	-2.4	-1.7	-0.3	-2.1
Back pain experienced in last month	1.2	1.8	3.3	0.3	-1.4	-1.3	-1.7	-1.3	-1.0	-1.8
Mineral and other dietary supplements	0.1	0.2	0.5	-0.6	-0.3	-0.1	-0.3	-0.1	-0.7	0.2
Breast cancer (self-reported)	2.1	2.5	3.8	-1.5	-1.9	-2.0	-1.6	-1.9	-1.0	-1.0
Asthma (self-reported)	1.9	3.8	7.7	0.7	2.8	2.7	1.8	2.5	1.0	-1.0
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.2	0.4	0.3	0.3	0.0	0.1	-0.4
Osteoarthritis (self-reported)	1.2	1.6	3.5	-0.3	-1.4	-1.3	-1.9	-1.2	-0.3	-1.6
Medication: Aspirin	0.3	0.4	1.4	-0.1	-0.5	-0.7	-0.4	-0.2	0.7	1.2
Medication: Gliclazide	0.6	0.6	1.8	-0.2	-1.0	-1.0	-0.7	-1.3	-0.1	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-0.7	-0.4	-0.4	0.4	-0.5	-0.9	0.3
Smoking status: Current	1.1	1.8	3.5	1.1	1.9	1.7	0.8	1.6	1.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	4.7	-0.6	1.6	1.7	1.8	1.7	1.1	2.2
Whole body water mass	0.2	0.9	1.9	-0.6	-1.1	-0.9	-0.5	-0.9	-1.0	-1.4
Leg predicted mass (right)	0.2	1.2	2.2	-0.1	-1.5	-1.3	-0.7	-1.4	-1.1	-1.0
Arm fat mass (left)	0.6	2.4	4.1	1.5	-2.0	-1.9	-1.7	-1.9	-0.8	0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	-0.9	0.5	0.5	0.5	0.6	1.1	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	3.4	-0.4	0.4	0.2	1.0	0.6	0.3	1.8
Miserableness	0.2	0.3	0.6	-0.7	-0.4	-0.6	-0.8	-0.7	0.4	-0.3
Guilty feelings	0.1	0.1	0.2	-0.4	0.1	0.2	-0.0	0.2	0.4	-0.4
Wears glasses or contact lenses	1.1	1.3	3.5	1.9	0.9	1.0	1.0	0.8	0.7	1.3
Ever taken oral contraceptive pill	0.5	0.6	0.9	-0.2	-0.7	-1.0	-0.9	-0.6	-0.9	0.9
Hearing aid user	0.5	0.6	1.9	0.6	0.4	0.6	0.4	0.7	1.4	0.8
Mother’s age at death	2.6	3.3	5.6	-0.1	2.4	2.3	2.3	2.1	0.9	1.1
Financial situation satisfaction	1.5	1.8	2.9	0.6	1.5	1.5	0.8	1.7	1.4	1.6
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.0	1.0	1.6	1.7	1.4	1.7	1.1	-0.5
Commuting to job workplace: Public transport	4.5	5.3	8.4	-2.5	2.3	1.8	2.3	2.4	1.7	2.9
Eye problems/disorders: Glaucoma	1.2	1.4	2.6	-0.5	1.6	1.5	1.3	1.6	0.8	-0.1
Medication: Blood pressure	0.8	1.5	3.2	-1.0	-1.8	-1.7	-1.1	-1.4	-0.8	0.0
Pain type(s) experienced in last month: Hip pain	5.8	7.3	11.5	1.7	-3.4	-3.1	-3.1	-3.2	-1.6	-2.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	0.3	0.6	0.5	0.5	0.4	1.1	0.3
High cholesterol (Self-reported)	0.8	1.3	2.6	-0.3	-1.5	-1.6	-1.4	-1.2	-0.1	-1.0
Medication: Bendroflumethiazide	0.2	0.3	1.5	-1.2	-0.1	-0.1	0.5	0.0	0.1	0.5
Medication: Paracetamol	1.7	2.7	4.7	-0.2	1.7	1.6	2.2	1.9	1.3	1.7
Medication: Lisinopril	0.6	0.7	2.2	-0.4	0.5	0.4	1.0	0.8	0.8	1.5
Medication: Atorvastatin	0.2	0.3	1.1	-1.0	-0.0	-0.1	0.2	0.0	0.2	-1.1
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.5	0.6	0.6	0.5	0.6	0.7	0.0
Alcohol drinker status: Never	0.6	0.7	1.5	0.4	1.2	1.1	1.1	0.8	0.2	-0.1
Ever smoked	0.3	0.5	0.8	-0.6	-0.6	-0.8	-0.9	-0.8	0.4	-0.7
Basal metabolic rate	0.2	1.2	1.8	-0.1	-1.4	-1.1	-0.8	-1.2	-1.2	-1.2
Leg fat percentage (left)	0.6	2.2	3.9	2.0	-1.7	-1.6	-1.8	-1.4	-0.9	-0.0
Arm fat-free mass (left)	0.1	0.7	2.0	-0.3	-0.9	-0.7	-0.5	-0.8	-0.9	-1.4
Number of operations (self-reported)	0.3	0.5	1.1	0.5	-0.9	-0.8	-1.0	-0.7	-0.1	-0.4
Average weekly beer plus cider intake	4.8	6.9	10.6	-0.2	-2.9	-2.9	-3.1	-2.6	-2.0	-3.2
Irritability	1.0	1.6	7.3	-2.7	0.7	0.5	0.9	0.6	1.5	-0.2
Risk taking	3.5	5.2	9.1	-0.0	-2.6	-2.7	-3.0	-2.4	-1.7	-2.1
Ever had prostate specific antigen (PSA) test	3.3	3.8	6.1	0.8	-2.3	-2.3	-2.5	-2.1	-1.1	-1.9
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-0.5	0.4	0.2	-0.4	0.1	1.1	-0.8
Age started oral contraceptive pill	3.3	4.1	8.9	-1.0	2.2	2.1	3.0	2.1	1.0	2.1
Diastolic blood pressure, automated reading	0.3	0.9	1.3	-1.1	-1.0	-1.2	-1.0	-0.9	-0.6	-0.6
Ever depressed for a whole week	0.7	0.9	1.7	1.1	-0.7	-0.7	-1.3	-1.0	0.1	-1.2
Unable to work because of sickness or disability	0.4	0.5	1.0	0.8	-0.9	-0.9	-1.0	-0.7	-0.3	-0.3
Commuting to job workplace: Cycle	2.0	2.4	4.6	-2.1	1.4	1.1	2.0	1.5	0.7	1.6
Myopia	1.3	1.8	3.3	1.5	-1.4	-1.3	-1.8	-1.1	-1.0	-1.2
Vascular/heart problems diagnosed by doctor	0.3	1.0	1.7	1.2	1.3	1.3	0.5	0.8	0.8	-0.6
Cholesterol lowering medication	0.2	0.3	0.8	-0.6	-0.7	-0.6	-0.9	-0.4	0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.4	0.3	-0.9	-1.0	-1.2	-1.0	0.6	-0.4
Pain experienced in last month	0.8	1.4	3.5	0.5	1.3	1.1	1.0	1.3	0.6	1.9
Supplements: Calcium	0.8	0.8	1.2	-1.1	1.1	0.6	0.7	0.9	1.1	0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.4	-0.3	-0.1	-0.7	-0.2	0.8	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.2	-0.7	0.3	0.3	0.9	1.0	0.6	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.4	-0.4	-1.3	-1.5	-1.4	-1.3	0.4	-0.2
Heart disease (siblings)	1.0	1.2	2.7	-0.5	1.2	1.1	0.8	1.1	1.6	1.1
Alcohol drinker status: Previous	0.8	0.9	1.9	0.2	-1.2	-1.2	-1.0	-0.5	-1.4	-0.5
Pack years of smoking	0.1	0.2	0.4	-0.3	0.4	0.4	0.7	0.3	-0.3	-0.4
Impedance of whole body	0.2	1.1	1.8	0.1	1.2	1.1	1.0	1.3	1.1	0.7
Leg fat mass (left)	0.8	3.0	4.6	1.9	-2.2	-2.0	-1.9	-1.9	-1.3	-0.4
Arm predicted mass (left)	0.2	1.1	1.9	-0.5	-1.2	-1.0	-0.8	-1.0	-1.1	-1.4