Hub : Genes

PTAFR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.4930 0.1190 4.5e-05 0.099 NA 0.065 NA 0.170 7.6e-04 NA 5.7e-03 NA 1.0e-05
2 GTEx Skin Not Sun Exposed Suprapubic 0.2280 0.0870 4.3e-03 0.136 NA 0.081 NA 0.101 6.5e-08 NA 3.2e-05 NA 3.7e-06
3 GTEx Skin Sun Exposed Lower leg 0.2650 0.0730 3.9e-04 0.135 NA 0.107 NA 0.118 3.1e-11 NA 3.5e-09 NA 5.9e-10
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0366 0.0203 2.5e-03 0.023 0.010 0.015 NA 0.017 1.2e-03 0.02400 7.4e-03 NA 4.2e-03
5 TCGA Lung Squamous Cell Carcinoma 0.0710 0.0333 1.9e-03 0.037 0.000 0.015 NA 0.029 4.4e-05 0.37000 7.7e-03 NA 2.6e-04
6 TCGA Ovarian Serous Cystadenocarcinoma 0.1350 0.0670 8.7e-04 0.033 0.047 0.017 NA 0.027 2.4e-03 0.00041 2.2e-02 NA 5.6e-03
7 TCGA Thyroid Carcinoma 0.0730 0.0370 2.1e-03 0.022 0.018 0.018 NA 0.021 2.9e-03 0.00610 6.5e-03 NA 3.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.8 1.2 2.2 0.2 1.2 1.3 0.0 1.5 1.1 1.3
Bipolar Disorder or Schizophrenia 1.6 3.9 6.0 -2.4 2.0 1.8 0.0 2.4 1.9 2.3
Depressed Affect (Nagel 2018) 0.3 0.7 3.4 -1.8 0.2 0.1 0.5 0.0 1.1 0.4
Depression (Nagel 2018) 0.4 0.6 1.7 -1.0 -0.5 -0.5 -0.7 -0.7 0.2 -1.3
Intelligence (Savage-Jansen 2018) 0.2 0.8 1.4 -0.3 -1.1 -1.2 -0.9 -0.7 -0.7 1.0
Neuroticism (Nagel 2018) 0.5 1.3 6.1 -2.5 -0.2 -0.3 0.1 -0.3 1.4 -0.8
Schizophrenia (2018) 1.5 3.1 5.5 -2.3 1.6 1.3 0.9 1.9 2.0 1.8
Schizophrenia vs Biploar Disorder 0.7 1.0 3.8 -1.9 -0.8 -1.0 0.0 -0.5 0.3 0.9
Worry (Nagel 2018) 0.6 1.3 6.6 -2.6 0.2 -0.1 0.2 0.0 1.5 -0.5
Alzheimer’s Disease (in mother) 0.3 0.3 1.3 1.1 0.4 0.4 0.4 0.7 0.0 0.5
Alzheimer’s Disease (in father) 1.0 1.1 1.9 1.1 -1.4 -1.2 -1.1 -1.4 -0.3 -0.1
Alzheimer’s Disease (including proxy) 0.3 0.5 2.1 1.5 -0.5 -0.4 -0.6 -0.4 -0.1 0.5
Crohns Disease (2017) 0.5 1.2 5.8 0.1 0.2 0.3 -0.1 0.4 -1.5 -2.4
Irritable Bowel Disease (IBD) 0.8 1.9 4.2 0.2 1.8 1.9 1.2 2.1 0.6 -0.6
Ulcerative Colitis (UC) 2.1 4.0 7.2 -0.1 2.5 2.5 1.8 2.7 2.1 1.0
Major Depression (MDD) 0.0 0.1 0.2 -0.0 -0.2 -0.1 0.0 0.2 0.4 0.3
Reaction Time 0.9 1.6 10.4 3.2 0.3 0.8 0.3 0.2 0.4 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 4.1 -0.4 0.2 0.1 0.8 0.5 0.1 2.0
Breast Cancer 0.4 0.9 1.7 -1.3 0.8 0.7 1.1 1.1 0.4 0.8
Ovarian Cancer 0.3 0.4 1.7 -0.6 -0.1 -0.3 -0.6 -0.1 0.2 -1.3
Prostate Cancer 1.7 2.3 5.1 1.5 -1.3 -1.0 -1.1 -1.5 -1.7 -2.3
Age at First Birth 0.1 0.1 0.2 0.3 0.1 0.4 0.3 0.3 0.2 -0.4
Bipolar Disorder (2011) 1.3 1.2 2.9 -0.4 1.7 1.7 0.0 1.7 0.0 0.0
Body Mass Index (BMI) (2010) 3.5 4.8 7.0 1.1 -2.6 -2.4 -2.2 -2.5 -2.6 -1.2
Coronary Artery Disease (CAD) 0.5 0.5 1.3 0.5 -0.8 -0.8 0.0 -0.9 0.3 1.2
Crohns Disease (2012) 0.4 0.6 1.7 -0.6 0.9 0.9 0.0 1.3 -0.6 -0.5
Mean Putamen Volume 0.5 0.6 1.4 -1.2 -0.8 -0.8 -0.5 -0.8 -0.2 -0.8
Fasting Glucose 0.5 0.5 1.6 0.9 0.2 0.3 0.3 0.5 1.0 1.3
HbA1C 1.0 1.1 2.0 1.1 1.1 1.2 1.2 1.4 0.4 0.4
HDL Cholesterol 0.6 0.9 3.3 -1.6 0.4 0.4 0.4 0.3 0.4 -1.8
LDL Cholesterol 1.8 2.8 5.4 2.3 -1.6 -1.3 -1.8 -1.4 -1.7 -1.5
Lupus 0.3 0.4 2.0 -1.4 -0.3 -0.4 0.0 0.1 0.3 0.9
Neuroticism (2016) 0.2 0.3 0.7 0.0 -0.4 -0.6 -0.4 -0.2 0.9 -0.7
Primary Biliary Cirrhosis 0.8 1.2 2.5 -0.8 1.6 1.5 1.3 1.1 0.3 0.1
Rheumatoid Arthritis 0.2 0.2 0.8 0.9 0.4 0.6 0.5 0.4 -0.1 0.0
Schizophrenia (2014) 1.5 3.2 8.3 -2.1 1.5 1.2 0.0 1.8 1.8 2.9
Triglycerides 0.7 1.1 1.7 0.5 -1.2 -1.1 -1.2 -1.3 -0.9 -0.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.1 -0.2 -0.5 0.0 -0.2 -0.1 0.4
Ulcerative Colitis 1.9 2.7 5.1 0.5 2.3 2.2 0.0 2.2 1.1 1.7
Blood Eosinophil Count 1.6 12.4 56.7 -1.2 1.6 1.2 3.0 2.7 2.8 7.5
Blood Platelet Count 0.1 1.4 2.2 -0.9 1.1 1.1 1.5 1.5 -0.5 -1.2
Blood Red Count 0.4 3.7 14.1 -0.0 1.3 1.4 2.4 1.1 1.1 3.8
Blood White Count 0.2 1.7 3.3 -1.3 1.1 0.7 1.5 1.4 1.1 1.8
Heel T-Score 0.1 1.0 4.0 0.6 -0.9 -0.6 -0.6 -0.7 0.5 2.0
BMI 0.7 4.1 5.6 2.4 -2.2 -1.9 -2.2 -2.2 -2.3 -0.3
Height 0.1 1.2 7.0 -0.4 -0.0 0.1 0.3 0.1 -1.1 -2.6
Waist Hip Ratio (WHR) 0.7 3.2 5.7 -0.7 -1.8 -2.0 -2.4 -2.0 -0.9 -2.0
Systolic Blood Pressure 0.5 2.4 5.6 0.0 1.3 1.3 2.0 1.6 1.1 2.4
Smoking Status 0.1 0.3 1.3 0.8 0.3 0.1 -0.4 -0.0 -0.3 -1.2
Allergy or Eczema 2.7 7.2 14.8 -0.4 3.8 3.9 3.2 3.2 0.7 -0.4
Cardiovascular Disease 0.7 2.2 4.5 -1.2 -2.1 -2.1 -1.3 -1.5 -1.1 -0.0
Hypothyroidism (self reported) 3.1 7.2 13.2 -1.8 2.5 2.3 2.7 2.6 3.6 2.9
Respiratory disease 2.9 6.4 12.8 0.4 3.5 3.6 2.5 3.4 1.3 0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 2.0 -1.4 -0.3 -0.4 0.1 -0.4 -0.2 0.3
Lung FEV1/FVC ratio 0.2 1.0 3.5 1.9 -0.8 -0.7 -0.2 -1.0 -1.1 0.1
Lung FVC 0.0 0.1 0.2 0.4 0.1 0.3 -0.0 0.1 -0.3 -0.5
Neuroticism 0.5 1.3 6.0 -2.4 -0.1 -0.4 -0.1 -0.3 1.4 -0.9
Chronotype (morning person) 0.1 0.3 0.9 -0.4 -0.6 -0.6 -0.3 -0.1 -1.0 -0.5
Hair Pigment 0.1 1.6 3.0 -0.2 1.6 1.7 1.5 1.7 0.1 -0.7
Tanning 0.1 0.9 2.3 -0.5 -0.8 -0.7 -0.9 -1.0 -1.5 -0.9
Hand grip strength (left) 0.6 1.6 3.0 -0.9 1.6 1.7 0.9 1.7 -0.0 -1.1
Number of treatments/medications taken 0.3 0.5 1.6 0.4 0.3 0.1 0.2 0.6 1.2 1.1
Average weekly spirits intake 0.1 0.2 0.9 1.0 -0.1 -0.0 0.2 0.0 -0.4 -0.0
Sensitivity / hurt feelings 1.3 2.3 4.3 1.1 -1.5 -1.5 -1.7 -1.5 -0.9 -2.1
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.5 -1.6 0.6 0.6 0.2 0.6 0.5 -0.6
Hearing difficulty/problems: Yes 0.5 0.7 1.7 0.8 -0.9 -0.8 -1.3 -0.7 -0.4 -0.8
Relative age of first facial hair 0.1 0.2 0.8 0.4 0.3 0.3 0.2 -0.0 0.9 -0.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.4 0.6 -0.0 0.2 -0.2 -0.0 -0.3 0.3
Ever used hormone-replacement therapy (HRT) 1.1 1.3 3.3 1.0 1.3 1.2 0.4 0.9 1.8 1.0
Ever had hysterectomy (womb removed) 1.7 1.9 3.3 0.5 -1.7 -1.8 -1.8 -1.6 -1.1 -0.5
Systolic blood pressure, automated reading 0.1 0.3 0.8 0.8 0.4 0.4 0.4 0.4 0.2 0.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 -0.8 0.3 0.3 0.8 0.3 0.8 0.1
Angina 0.2 0.3 1.1 1.1 0.2 0.3 -0.0 0.5 0.4 0.6
Medication for hormone replacement therapy 0.5 0.6 1.3 0.9 0.9 1.0 -0.0 1.1 -0.5 0.1
Vitamin and mineral supplements 0.3 0.4 2.1 -0.9 0.1 0.3 0.3 0.2 -1.4 -0.0
Supplements: Zinc 0.6 0.7 2.0 -1.4 -0.0 -0.1 -0.2 0.2 0.8 -1.4
Medication: Co-codamol 0.5 0.5 2.4 1.6 0.4 0.6 0.3 0.6 -0.0 -0.7
Medication: Metformin 0.4 0.6 1.6 -1.2 0.0 0.0 0.3 0.2 1.3 0.8
Diabetes (father) 0.9 1.1 3.5 0.6 -1.1 -1.0 -1.9 -0.6 -0.2 -1.2
Diabetes (mother) 0.1 0.1 0.4 -0.3 -0.2 -0.2 -0.2 0.1 0.7 0.2
Severe depression (siblings) 0.9 1.0 3.6 1.4 -0.6 -0.8 -1.9 -0.6 0.4 0.1
Pack years adult smoking proportion 0.1 0.2 0.4 -0.3 0.3 0.3 0.5 0.2 -0.4 -0.6
Impedance of leg (right) 0.1 0.5 1.1 0.4 0.9 0.9 0.3 1.1 0.3 -0.4
Leg fat-free mass (left) 0.4 1.9 3.4 0.0 -1.8 -1.6 -1.1 -1.8 -1.3 -1.1
Trunk fat percentage 0.5 1.9 3.6 1.9 -1.6 -1.5 -1.4 -1.4 -0.2 1.0
Hand grip strength (right) 0.3 0.9 1.7 -1.1 0.9 1.0 0.6 1.0 -0.6 -1.3
Townsend deprivation index at recruitment 0.2 0.3 1.3 -1.2 0.3 0.0 -0.2 0.2 0.3 0.5
Current tobacco smoking 0.9 1.5 3.2 0.6 1.8 1.6 0.6 1.5 1.2 -0.2
Average weekly fortified wine intake 1.1 1.2 3.0 0.9 1.1 1.2 1.2 0.8 -1.7 -0.2
Maternal smoking around birth 1.3 1.9 8.2 0.2 -0.9 -0.7 -1.5 -0.7 -1.1 -2.9
Fed-up feelings 0.1 0.2 0.5 -0.6 0.2 0.2 -0.2 0.1 0.4 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 1.5 -0.9 -0.1 -0.0 -0.8 -0.1 0.4 -1.2
Relative age voice broke 0.2 0.3 0.9 -0.7 -0.2 -0.3 -0.5 -0.4 0.4 -0.9
Taking other prescription medications 0.1 0.1 0.4 -0.0 -0.2 -0.3 -0.4 0.1 0.7 0.0
Age when periods started (menarche) 0.1 0.2 0.9 -0.7 -0.2 -0.3 -0.4 -0.1 0.4 -0.9
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.8 0.3 -0.7 -1.0 -1.2 -0.9 0.2 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 2.8 -1.5 1.4 1.3 1.7 1.2 1.4 0.1
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.6 0.8 -1.0 -1.0 -1.3 -1.1 -1.1 0.2
Qualifications: CSEs or equivalent 1.2 1.6 3.6 0.0 -1.0 -0.9 -1.9 -1.3 -0.9 -1.8
Serious illness, injury or assault to yourself 1.8 2.2 3.6 1.1 -1.5 -1.3 -1.6 -1.6 -1.2 -1.9
High blood pressure 0.5 1.3 2.3 -1.5 -1.4 -1.4 -0.6 -1.1 -1.0 0.1
Hayfever, allergic rhinitis or eczema 2.4 5.3 11.6 -0.4 3.2 3.4 2.5 2.5 1.1 -1.3
Multivitamins +/- minerals 0.2 0.3 1.9 -0.3 0.3 0.1 0.0 0.2 1.4 0.0
Stomach or abdominal pain in last month 0.4 0.5 1.2 -0.1 -0.9 -0.8 -1.1 -0.8 0.2 0.2
Supplements: Glucosamine 1.8 2.4 3.4 1.1 -1.8 -1.8 -1.7 -1.8 -1.0 -1.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.9 -0.2 0.3 0.4 0.6 0.6 1.4 1.2
Medication: Atenolol 0.2 0.3 1.6 -1.2 0.2 0.0 0.2 0.4 0.4 0.1
Medication: Levothyroxine sodium 3.0 5.2 9.7 -1.9 2.3 2.0 2.1 2.1 3.1 2.2
Sitting height 0.3 2.4 7.3 -2.7 1.2 1.1 1.9 1.4 0.6 0.9
Chronic bronchitis/emphysema (father) 0.1 0.1 0.6 -0.8 0.3 0.3 -0.2 0.4 -0.0 -0.1
High blood pressure (mother) 1.4 2.0 3.3 -0.7 1.8 1.7 1.6 1.7 1.4 -0.2
Body mass index (BMI) 0.7 2.8 4.2 1.7 -2.0 -1.9 -1.9 -2.0 -1.1 0.2
Impedance of leg (left) 0.3 1.4 3.3 0.2 1.6 1.5 0.9 1.8 0.8 0.1
Leg predicted mass (left) 0.3 1.8 3.3 -0.1 -1.8 -1.6 -1.1 -1.7 -1.3 -1.1
Trunk fat mass 0.4 1.8 2.9 1.6 -1.7 -1.6 -1.5 -1.5 -0.5 0.3
Waist circumference 0.9 3.1 4.6 1.5 -2.1 -2.1 -2.1 -2.1 -1.1 -0.7
Number of incorrect matches in round 0.8 1.3 2.4 0.8 1.4 1.6 1.3 1.1 0.7 0.9
Past tobacco smoking 0.5 0.9 1.7 -0.3 1.0 1.3 1.1 1.2 -0.3 0.7
Alcohol usually taken with meals 0.2 0.3 1.4 0.5 -0.4 -0.3 -0.1 -0.2 -1.2 0.2
Nervous feelings 0.3 0.6 1.6 -1.3 0.5 0.3 1.0 0.3 1.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.5 -1.6 0.5 0.4 0.7 0.6 0.7 -0.0
Hearing difficulty/problems with background noise 0.9 1.4 2.7 -0.7 -1.4 -1.6 -1.5 -1.2 0.8 0.5
Hair/balding pattern: Pattern 2 0.6 0.8 1.7 -0.5 1.1 1.3 0.6 1.0 0.4 -0.9
Had menopause 1.1 1.3 2.8 -0.6 1.2 0.9 1.1 1.1 1.7 1.2
Had other major operations 5.0 6.1 10.3 0.5 -3.0 -3.0 -3.2 -2.8 -1.5 -2.0
Forced vital capacity (FVC) 0.2 0.9 3.0 -1.7 0.6 0.6 0.6 0.5 -0.5 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.7 4.0 5.1 -1.8 2.2 2.0 2.2 2.0 2.3 1.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 4.2 2.0 -0.2 -0.1 -1.1 -0.5 0.1 -0.7
Qualifications: None of the above 0.1 0.3 0.6 0.4 0.4 0.4 0.4 0.6 0.6 0.8
Financial difficulties in last 2 years 0.4 0.5 1.3 -0.5 -0.1 -0.4 -0.8 -0.2 1.2 1.0
Mouth/teeth dental problems 0.5 0.8 2.5 -0.1 -0.7 -0.6 -0.6 -0.5 -1.3 -1.6
Heart attack 0.2 0.3 0.9 -0.4 0.0 0.0 0.6 0.6 0.4 1.0
Allergy 2.1 4.9 10.7 -0.0 -3.1 -3.3 -2.4 -2.5 -1.3 0.9
Pain all over the body in last month 2.0 2.2 5.1 -0.7 1.5 1.6 0.9 1.5 2.2 1.5
Diabetes (self-reported) 0.7 1.0 1.9 -0.7 -1.3 -1.3 -0.7 -1.4 0.0 -0.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.7 -0.3 1.1 1.1 1.0 1.0 0.0 -1.3
Medication: Ramipril 0.2 0.2 0.7 0.9 -0.3 -0.2 0.5 -0.1 -0.5 0.0
Medication: Simvastatin 0.6 0.8 1.8 0.6 -1.4 -1.3 -1.1 -0.9 0.2 -0.1
Fluid intelligence score 0.3 0.7 1.6 -0.7 0.6 0.5 1.0 1.0 0.1 1.2
Illnesses of siblings 0.4 0.5 1.7 -1.3 0.5 0.6 0.1 0.7 -0.1 -1.0
Neuroticism score 0.6 1.2 4.3 -2.1 -0.4 -0.7 -0.6 -0.5 0.9 -1.4
Weight 0.3 1.5 2.5 1.2 -1.6 -1.4 -1.2 -1.4 -0.9 -0.5
Impedance of arm (right) 0.2 0.9 1.3 0.6 1.1 1.0 0.8 1.1 0.9 0.8
Arm fat percentage (right) 0.8 3.3 6.4 2.5 -2.1 -1.9 -2.0 -1.9 -0.7 0.4
Trunk fat-free mass 0.1 0.5 2.0 -0.7 -0.5 -0.3 -0.1 -0.3 -0.8 -1.4
Hip circumference 0.1 0.6 2.0 1.4 -0.7 -0.6 -0.3 -0.6 -0.3 0.9
Time employed in main current job 0.5 0.5 0.8 0.6 0.8 0.8 0.8 0.9 0.4 0.7
Alcohol intake versus 10 years previously 0.5 0.8 1.3 0.9 -1.0 -1.0 -1.0 -1.1 -0.4 0.4
Father’s age at death 1.3 1.8 3.4 0.9 -1.7 -1.4 -1.4 -1.8 -1.1 -0.6
Worrier / anxious feelings 0.4 0.8 3.1 -1.8 0.3 0.0 0.5 0.0 1.4 -0.3
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 4.1 -0.3 -1.8 -2.0 -2.0 -1.7 -0.1 -1.0
Falls in the last year 0.7 1.0 2.0 -0.9 -0.9 -1.0 -0.5 -1.3 -0.3 -1.4
Hair/balding pattern: Pattern 3 4.5 6.6 9.3 -0.8 2.9 2.7 3.0 3.0 2.4 2.5
Number of live births 0.4 0.6 2.1 1.3 0.3 0.5 -0.1 0.2 -0.2 -1.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.7 -0.8 0.0 0.2 0.3 0.0 -1.1 -1.3
Pulse rate 0.7 1.1 1.7 1.1 1.2 1.3 0.9 1.0 1.0 0.8
Happiness 1.0 1.2 2.8 -0.3 -0.9 -1.0 -1.6 -1.2 0.0 -1.7
Noisy workplace 2.5 3.1 14.2 3.8 1.3 1.6 0.5 1.2 0.4 1.2
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.5 -1.1 0.9 0.9 1.2 0.8 0.4 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 0.3 -0.3 -0.3 -0.5 -0.1 -0.3 0.6
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.8 0.4 0.4 0.2 0.3 0.3 0.6
Asthma 2.4 4.7 9.2 0.8 3.0 3.0 2.1 2.7 1.1 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.0 0.2 0.1 -0.3 0.4 -0.2 -0.4
Medication: Cholesterol lowering 0.3 0.4 1.0 0.7 -0.9 -1.0 -0.5 -0.6 0.1 -0.6
Depression (self-reported) 1.0 1.2 1.9 -0.3 -1.3 -1.4 -1.3 -1.4 -0.4 -0.9
Medication: Lansoprazole 1.2 1.4 2.3 -0.3 1.3 1.3 1.2 1.4 0.8 1.5
Prospective memory result 0.5 0.6 2.6 1.6 0.1 0.3 0.6 -0.6 -1.0 -0.3
Lung cancer (father) 0.4 0.4 2.2 1.5 -0.5 -0.3 -0.5 -0.2 -0.4 0.1
Illnesses of mother 4.9 6.0 10.5 0.3 -3.0 -2.8 -2.7 -3.2 -2.1 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.2 -0.2 0.6 0.8 1.1 0.5 -0.2 -0.0
Pulse wave Arterial Stiffness index 0.6 0.8 4.3 2.1 -0.2 0.0 0.1 -0.4 0.2 0.8
Impedance of arm (left) 0.1 0.4 0.8 0.2 0.6 0.5 0.6 0.6 0.9 0.9
Arm fat mass (right) 0.7 2.9 4.3 2.0 -2.1 -1.9 -1.9 -1.9 -1.0 0.1
Trunk predicted mass 0.1 0.6 2.3 -0.8 -0.5 -0.3 -0.0 -0.3 -0.9 -1.5
Standing height 0.1 1.4 2.1 -1.4 1.1 1.1 1.5 1.2 0.4 -1.3
Length of working week for main job 1.9 2.1 5.3 -2.3 1.0 0.7 0.6 1.5 1.8 1.3
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.6 0.1 0.2 -0.3 0.6 0.2 -0.0
Breastfed as a baby 0.1 0.1 0.4 -0.6 0.1 0.1 0.2 0.3 0.3 0.3
Tense / ‘highly strung’ 0.6 1.0 3.6 -1.9 -0.4 -0.5 -0.8 -0.6 0.0 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.9 -1.2 -1.0 -1.2 -1.7 -1.2 0.6 -1.2
Hair/balding pattern: Pattern 4 0.3 0.7 1.1 -0.1 -1.0 -1.0 -1.0 -0.9 -1.0 -0.0
Birth weight of first child 0.6 1.0 2.3 1.5 0.9 1.3 0.7 0.4 -0.6 -1.1
Peak expiratory flow (PEF) 0.2 0.5 1.7 -0.9 -0.4 -0.2 -0.0 -0.3 -1.3 -1.0
Pulse wave reflection index 0.8 1.0 2.1 0.4 -1.3 -1.4 -0.4 -1.4 -1.0 0.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 2.0 1.4 0.2 0.2 -0.3 0.1 -0.2 0.8
Loud music exposure frequency 0.3 0.3 0.9 0.4 -0.5 -0.4 -0.2 -0.5 -0.9 -0.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 6.7 -2.6 -0.7 -0.8 -0.8 -0.7 0.3 -0.8
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.6 0.2 1.0 1.0 1.1 1.2 0.7 2.1
Blood clot in the leg (DVT) 0.6 0.8 1.6 -0.4 -1.0 -1.3 -1.1 -1.0 0.7 -0.2
Medication: Paracetamol 0.3 0.4 1.3 0.4 0.6 0.7 1.1 0.8 0.0 0.1
Headache pain in last month 0.7 1.2 2.1 -1.5 -1.0 -1.1 -0.7 -1.1 -1.0 -1.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.0 -0.4 1.4 1.4 0.9 1.0 0.1 0.0
Glaucoma (self-reported) 0.4 0.5 1.0 0.3 0.9 0.8 0.9 1.0 0.3 0.1
Gout (self-reported) 0.1 0.2 0.6 -0.0 0.4 0.7 0.8 0.3 0.0 -0.3
Hypothyroidism/myxoedema (self-reported) 3.1 6.1 9.1 -1.4 2.5 2.3 2.5 2.6 3.0 2.6
Medication: Amlodipine 0.1 0.2 0.5 0.3 0.3 0.2 0.4 0.5 0.1 0.7
Medication: Ventolin 100micrograms inhaler 2.0 2.6 5.9 1.1 2.3 2.4 1.1 1.8 0.9 -0.9
Birth weight 1.8 4.0 6.3 -0.6 2.5 2.2 2.4 2.5 1.6 1.3
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.2 1.3 1.3 1.5 0.8 1.4 -0.2 0.4
High blood pressure (siblings) 1.0 1.4 6.5 1.6 0.5 0.4 0.6 0.4 0.3 2.6
Forced vital capacity (FVC), Best measure 0.2 0.8 1.5 -0.5 1.0 1.2 1.2 1.0 0.1 -0.5
Body fat percentage 0.7 2.6 4.3 2.1 -1.9 -1.8 -1.8 -1.7 -0.5 0.6
Leg fat percentage (right) 0.8 3.0 4.9 2.2 -2.0 -1.9 -2.1 -1.8 -1.1 -0.1
Arm fat-free mass (right) 0.2 1.0 2.0 -0.7 -1.1 -1.0 -0.5 -0.9 -0.9 -1.4
Exposure to tobacco smoke outside home 0.7 1.0 6.1 -0.2 0.1 0.1 -0.6 -0.4 0.1 -2.5
Comparative body size at age 10 0.3 0.7 3.6 -0.3 0.2 0.0 1.2 0.2 0.2 1.9
Number of full brothers 0.3 0.4 1.0 1.0 -0.6 -0.4 -0.5 -0.5 -0.8 -0.6
Worry too long after embarrassment 0.5 0.8 2.8 -0.7 -0.7 -0.9 -0.4 -0.9 -0.0 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.4 -0.9 -1.3 -1.3 -1.1 -1.2 -0.1 -1.6
Wheeze or whistling in the chest in last year 0.1 0.3 0.5 0.7 0.5 0.5 -0.5 0.4 0.4 -0.7
Number of children fathered 0.4 0.5 2.4 1.5 -0.2 -0.0 -0.6 -0.1 -0.8 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.5 0.2 0.6 0.5 0.7 0.6 1.6 0.2
Age at first live birth 0.7 1.3 3.2 -1.0 1.2 1.3 1.8 1.0 0.8 0.5
Pulse wave peak to peak time 0.7 0.9 4.9 -2.2 0.3 0.1 -0.0 0.6 -0.2 -0.9
Health satisfaction 2.5 3.2 4.9 1.8 -2.2 -2.0 -2.0 -2.0 -1.1 -0.9
Shortness of breath walking on level ground 1.9 2.2 3.8 1.9 -1.6 -1.6 -2.0 -1.4 -1.0 0.1
Qualifications: College or University degree 1.1 3.3 7.5 -1.0 1.7 1.5 2.7 1.4 1.3 2.5
Eye problems/disorders: None of the above 1.1 1.3 1.9 0.3 -1.4 -1.4 -1.3 -1.3 -1.4 -0.1
Mouth/teeth dental problems: Loose teeth 2.9 3.5 5.7 0.3 2.4 2.3 2.3 2.4 0.8 1.4
Emphysema/chronic bronchitis 0.8 0.9 2.0 1.2 -0.7 -0.4 -1.2 -0.7 -0.5 -1.4
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 0.8 0.5 0.7 0.1 -0.0 -0.5 -0.6
Neck or shoulder pain in last month 1.2 1.7 6.0 0.8 -1.1 -0.9 -0.9 -1.0 -1.3 -2.5
Medication: Blood pressure 0.1 0.3 1.5 -0.0 -0.1 -0.2 0.3 0.2 0.5 1.2
Angina (self-reported) 0.3 0.4 1.3 1.1 0.1 0.2 -0.2 0.5 0.5 0.8
Migraine (self-reported) 0.4 0.5 1.1 0.1 -0.5 -0.5 -0.5 -0.7 -1.0 -1.1
Medication: Ibuprofen 0.0 0.1 0.2 0.0 0.3 0.2 -0.1 0.5 0.1 -0.1
Medication: Allopurinol 0.1 0.2 0.5 0.3 0.4 0.7 0.7 0.4 -0.2 0.1
Medication: Omeprazole 0.4 0.5 0.9 0.7 -0.5 -0.6 -0.9 -0.5 0.8 -0.4
Medication: Seretide 50 evohaler 1.3 1.5 4.3 0.3 -0.9 -0.9 -1.9 -1.1 0.2 -2.1
Mean time to correctly identify matches 1.1 2.1 12.9 3.6 -0.3 0.2 -0.3 -0.5 0.7 -0.8
Heart disease (mother) 0.9 1.1 1.8 -0.5 1.2 0.9 1.0 1.2 1.4 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.5 1.2 0.2 0.1 -0.2 0.0 -0.4 -0.8
Whole body fat mass 0.6 2.5 4.1 1.7 -2.0 -1.9 -1.7 -1.8 -0.9 0.2
Leg fat mass (right) 1.0 3.7 5.8 1.9 -2.4 -2.2 -2.1 -2.2 -1.5 -0.5
Arm predicted mass (right) 0.2 0.9 1.5 -0.8 -1.2 -1.1 -0.6 -1.0 -0.7 -1.2
Pulse rate, automated reading 0.8 2.6 5.1 0.9 -1.6 -1.3 -2.3 -1.6 -1.2 -2.0
Alcohol intake frequency. 0.5 1.2 3.0 0.2 1.2 1.0 1.7 1.3 -0.1 1.1
Comparative height size at age 10 0.3 1.7 2.5 -1.4 1.5 1.4 1.6 1.4 1.1 -0.5
Number of full sisters 1.1 1.3 2.8 -0.5 -1.2 -1.3 -1.7 -1.1 -1.0 0.8
Suffer from ‘nerves’ 0.2 0.4 1.2 -1.0 -0.3 -0.4 -0.1 -0.3 0.3 -1.1
Overall health rating 1.1 2.4 5.8 -0.1 -1.8 -1.7 -2.4 -1.5 0.4 -1.5
Chest pain or discomfort 0.6 0.8 1.5 -0.2 -1.1 -1.1 -1.2 -0.7 -0.1 -1.2
Had major operations 1.3 1.5 2.8 -0.8 1.4 1.5 1.4 1.7 0.4 0.8
Age at last live birth 2.3 3.4 6.6 1.1 2.2 2.5 2.6 2.1 0.6 0.5
Family relationship satisfaction 0.6 0.8 1.9 0.4 -0.8 -0.9 -1.4 -0.8 -0.5 -1.0
Leg pain on walking 2.8 3.4 5.9 0.5 -2.3 -2.3 -2.4 -2.3 -1.0 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.5 -0.1 -0.4 -0.2 -0.8 -0.3 -0.0 -1.2
Commuting to job workplace: Car/motor vehicle 4.9 5.6 14.5 2.1 -2.0 -1.6 -2.5 -2.2 -1.5 -3.8
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 4.8 -0.5 1.1 1.1 2.2 1.3 0.0 1.3
Medication: Aspirin 0.3 0.4 0.8 -0.3 -0.6 -0.8 -0.4 -0.3 0.6 0.9
Supplements: Vitamin C 0.4 0.5 1.2 0.3 0.5 0.6 0.9 0.5 1.1 -0.6
Knee pain experienced in last month 0.2 0.3 0.7 -0.5 -0.8 -0.7 -0.5 -0.7 -0.1 -0.0
Hypertension (Self-reported) 0.5 1.5 2.8 -1.3 -1.7 -1.6 -0.9 -1.3 -0.9 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.5 -1.2 -0.5 -0.8 -0.7 -0.3 0.5 0.5
Illnesses of father: Heart disease 5.8 8.0 12.6 0.1 3.4 3.6 2.9 3.2 2.8 2.3
Illnesses of siblings: Diabetes 0.7 0.9 1.6 0.6 -1.1 -1.3 -0.8 -1.1 -1.0 -0.4
Smoking status: Previous 1.2 1.8 3.5 -0.5 -1.6 -1.9 -1.2 -1.8 -0.4 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 -0.2 1.0 1.1 1.3 1.2 -0.0 -0.7
Whole body fat-free mass 0.2 0.9 1.8 -0.5 -1.1 -0.8 -0.5 -0.9 -1.0 -1.3
Leg fat-free mass (right) 0.2 1.2 2.2 -0.1 -1.5 -1.3 -0.7 -1.4 -1.1 -1.0
Arm fat percentage (left) 0.9 3.8 6.0 2.2 -2.4 -2.3 -2.2 -2.2 -0.8 0.4
Average weekly red wine intake 1.1 1.6 2.7 -0.4 1.2 1.1 1.5 1.6 1.0 1.5
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.0 -0.1 -0.5 -0.5 -1.0 -0.7 -0.4 -0.1
Mood swings 0.2 0.4 1.7 0.1 -0.3 -0.3 -0.6 -0.5 -0.3 -1.3
Loneliness, isolation 2.3 3.1 7.1 -1.6 1.6 1.3 1.2 1.4 2.7 2.2
Long-standing illness, disability or infirmity 0.9 1.3 2.5 -0.3 -1.3 -1.3 -1.2 -1.1 -0.6 -1.6
Ever had bowel cancer screening 0.7 0.8 1.2 1.0 -0.9 -1.0 -1.0 -1.1 0.2 -0.6
Diabetes diagnosed by doctor 0.5 0.8 3.0 -1.7 -0.9 -0.8 -0.3 -1.0 -0.1 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.8 -1.7 -0.6 -0.5 -0.2 -0.4 0.9 -0.1
Friendships satisfaction 0.1 0.1 0.3 -0.2 -0.2 -0.4 -0.2 -0.3 -0.5 -0.1
Qualifications: nursing, teaching 0.7 1.0 2.3 -0.1 1.4 1.3 1.5 0.9 0.5 -0.0
Commuting to job workplace: Walk 1.2 1.3 6.2 -0.3 0.3 0.3 -0.1 0.5 1.5 2.5
Eye problems/disorders: Cataract 0.1 0.1 0.3 0.1 0.4 0.4 0.5 0.4 0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.3 -0.8 0.3 0.3 0.2 0.0 1.2 1.0
Medication for cholesterol 0.1 0.2 0.9 0.9 0.4 0.3 0.6 -0.0 -0.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 5.7 0.9 -1.9 -1.6 -2.4 -1.7 -0.3 -2.1
Back pain experienced in last month 1.2 1.8 3.3 0.3 -1.4 -1.3 -1.7 -1.3 -1.0 -1.8
Mineral and other dietary supplements 0.1 0.2 0.5 -0.6 -0.3 -0.1 -0.3 -0.1 -0.7 0.2
Breast cancer (self-reported) 2.1 2.5 3.8 -1.5 -1.9 -2.0 -1.6 -1.9 -1.0 -1.0
Asthma (self-reported) 1.9 3.8 7.7 0.7 2.8 2.7 1.8 2.5 1.0 -1.0
Osteoporosis (self-reported) 0.1 0.1 0.1 -0.2 0.4 0.3 0.3 0.0 0.1 -0.4
Osteoarthritis (self-reported) 1.2 1.6 3.5 -0.3 -1.4 -1.3 -1.9 -1.2 -0.3 -1.6
Medication: Aspirin 0.3 0.4 1.4 -0.1 -0.5 -0.7 -0.4 -0.2 0.7 1.2
Medication: Gliclazide 0.6 0.6 1.8 -0.2 -1.0 -1.0 -0.7 -1.3 -0.1 -0.3
Illnesses of father: None of the above (group 1) 0.2 0.3 0.9 -0.7 -0.4 -0.4 0.4 -0.5 -0.9 0.3
Smoking status: Current 1.1 1.8 3.5 1.1 1.9 1.7 0.8 1.6 1.3 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 4.7 -0.6 1.6 1.7 1.8 1.7 1.1 2.2
Whole body water mass 0.2 0.9 1.9 -0.6 -1.1 -0.9 -0.5 -0.9 -1.0 -1.4
Leg predicted mass (right) 0.2 1.2 2.2 -0.1 -1.5 -1.3 -0.7 -1.4 -1.1 -1.0
Arm fat mass (left) 0.6 2.4 4.1 1.5 -2.0 -1.9 -1.7 -1.9 -0.8 0.3
Number of self-reported non-cancer illnesses 0.3 0.5 1.2 -0.9 0.5 0.5 0.5 0.6 1.1 -0.4
Average weekly champagne plus white wine intake 0.5 0.7 3.4 -0.4 0.4 0.2 1.0 0.6 0.3 1.8
Miserableness 0.2 0.3 0.6 -0.7 -0.4 -0.6 -0.8 -0.7 0.4 -0.3
Guilty feelings 0.1 0.1 0.2 -0.4 0.1 0.2 -0.0 0.2 0.4 -0.4
Wears glasses or contact lenses 1.1 1.3 3.5 1.9 0.9 1.0 1.0 0.8 0.7 1.3
Ever taken oral contraceptive pill 0.5 0.6 0.9 -0.2 -0.7 -1.0 -0.9 -0.6 -0.9 0.9
Hearing aid user 0.5 0.6 1.9 0.6 0.4 0.6 0.4 0.7 1.4 0.8
Mother’s age at death 2.6 3.3 5.6 -0.1 2.4 2.3 2.3 2.1 0.9 1.1
Financial situation satisfaction 1.5 1.8 2.9 0.6 1.5 1.5 0.8 1.7 1.4 1.6
Tinnitus: Yes, now most or all of the time 1.6 1.8 3.0 1.0 1.6 1.7 1.4 1.7 1.1 -0.5
Commuting to job workplace: Public transport 4.5 5.3 8.4 -2.5 2.3 1.8 2.3 2.4 1.7 2.9
Eye problems/disorders: Glaucoma 1.2 1.4 2.6 -0.5 1.6 1.5 1.3 1.6 0.8 -0.1
Medication: Blood pressure 0.8 1.5 3.2 -1.0 -1.8 -1.7 -1.1 -1.4 -0.8 0.0
Pain type(s) experienced in last month: Hip pain 5.8 7.3 11.5 1.7 -3.4 -3.1 -3.1 -3.2 -1.6 -2.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.2 0.3 0.6 0.5 0.5 0.4 1.1 0.3
High cholesterol (Self-reported) 0.8 1.3 2.6 -0.3 -1.5 -1.6 -1.4 -1.2 -0.1 -1.0
Medication: Bendroflumethiazide 0.2 0.3 1.5 -1.2 -0.1 -0.1 0.5 0.0 0.1 0.5
Medication: Paracetamol 1.7 2.7 4.7 -0.2 1.7 1.6 2.2 1.9 1.3 1.7
Medication: Lisinopril 0.6 0.7 2.2 -0.4 0.5 0.4 1.0 0.8 0.8 1.5
Medication: Atorvastatin 0.2 0.3 1.1 -1.0 -0.0 -0.1 0.2 0.0 0.2 -1.1
Illnesses of father: High blood pressure 0.2 0.3 0.5 0.5 0.6 0.6 0.5 0.6 0.7 0.0
Alcohol drinker status: Never 0.6 0.7 1.5 0.4 1.2 1.1 1.1 0.8 0.2 -0.1
Ever smoked 0.3 0.5 0.8 -0.6 -0.6 -0.8 -0.9 -0.8 0.4 -0.7
Basal metabolic rate 0.2 1.2 1.8 -0.1 -1.4 -1.1 -0.8 -1.2 -1.2 -1.2
Leg fat percentage (left) 0.6 2.2 3.9 2.0 -1.7 -1.6 -1.8 -1.4 -0.9 -0.0
Arm fat-free mass (left) 0.1 0.7 2.0 -0.3 -0.9 -0.7 -0.5 -0.8 -0.9 -1.4
Number of operations (self-reported) 0.3 0.5 1.1 0.5 -0.9 -0.8 -1.0 -0.7 -0.1 -0.4
Average weekly beer plus cider intake 4.8 6.9 10.6 -0.2 -2.9 -2.9 -3.1 -2.6 -2.0 -3.2
Irritability 1.0 1.6 7.3 -2.7 0.7 0.5 0.9 0.6 1.5 -0.2
Risk taking 3.5 5.2 9.1 -0.0 -2.6 -2.7 -3.0 -2.4 -1.7 -2.1
Ever had prostate specific antigen (PSA) test 3.3 3.8 6.1 0.8 -2.3 -2.3 -2.5 -2.1 -1.1 -1.9
Fractured/broken bones in last 5 years 0.3 0.4 1.3 -0.5 0.4 0.2 -0.4 0.1 1.1 -0.8
Age started oral contraceptive pill 3.3 4.1 8.9 -1.0 2.2 2.1 3.0 2.1 1.0 2.1
Diastolic blood pressure, automated reading 0.3 0.9 1.3 -1.1 -1.0 -1.2 -1.0 -0.9 -0.6 -0.6
Ever depressed for a whole week 0.7 0.9 1.7 1.1 -0.7 -0.7 -1.3 -1.0 0.1 -1.2
Unable to work because of sickness or disability 0.4 0.5 1.0 0.8 -0.9 -0.9 -1.0 -0.7 -0.3 -0.3
Commuting to job workplace: Cycle 2.0 2.4 4.6 -2.1 1.4 1.1 2.0 1.5 0.7 1.6
Myopia 1.3 1.8 3.3 1.5 -1.4 -1.3 -1.8 -1.1 -1.0 -1.2
Vascular/heart problems diagnosed by doctor 0.3 1.0 1.7 1.2 1.3 1.3 0.5 0.8 0.8 -0.6
Cholesterol lowering medication 0.2 0.3 0.8 -0.6 -0.7 -0.6 -0.9 -0.4 0.2 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.4 0.3 -0.9 -1.0 -1.2 -1.0 0.6 -0.4
Pain experienced in last month 0.8 1.4 3.5 0.5 1.3 1.1 1.0 1.3 0.6 1.9
Supplements: Calcium 0.8 0.8 1.2 -1.1 1.1 0.6 0.7 0.9 1.1 0.8
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.4 -0.3 -0.1 -0.7 -0.2 0.8 -0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.2 -0.7 0.3 0.3 0.9 1.0 0.6 1.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.4 -0.4 -1.3 -1.5 -1.4 -1.3 0.4 -0.2
Heart disease (siblings) 1.0 1.2 2.7 -0.5 1.2 1.1 0.8 1.1 1.6 1.1
Alcohol drinker status: Previous 0.8 0.9 1.9 0.2 -1.2 -1.2 -1.0 -0.5 -1.4 -0.5
Pack years of smoking 0.1 0.2 0.4 -0.3 0.4 0.4 0.7 0.3 -0.3 -0.4
Impedance of whole body 0.2 1.1 1.8 0.1 1.2 1.1 1.0 1.3 1.1 0.7
Leg fat mass (left) 0.8 3.0 4.6 1.9 -2.2 -2.0 -1.9 -1.9 -1.3 -0.4
Arm predicted mass (left) 0.2 1.1 1.9 -0.5 -1.2 -1.0 -0.8 -1.0 -1.1 -1.4