Hub : Genes

DNAJC9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.015	0.0110	8.8e-03	0.020	0.008	0.018	0.010	0.012	1.5e-03	3.0e-02	2.5e-03	1.9e-02	1.0e-02
2	GTEx	Brain Cerebellar Hemisphere	0.155	0.1040	6.1e-03	0.071	NA	0.068	NA	0.083	7.0e-03	NA	8.3e-03	NA	3.8e-03
3	GTEx	Heart Left Ventricle	0.363	0.0979	2.0e-03	-0.005	NA	-0.005	NA	-0.004	8.0e-01	NA	9.1e-01	NA	5.9e-01
4	GTEx	Skin Sun Exposed Lower leg	0.053	0.0460	1.7e-03	0.002	NA	0.014	NA	0.013	2.3e-01	NA	2.1e-02	NA	2.5e-02
5	ROSMAP	Brain Pre-frontal Cortex	0.306	0.0677	3.6e-06	-0.002	0.056	0.022	0.071	0.000	6.0e-01	9.8e-08	7.2e-04	1.8e-09	3.6e-01
6	TCGA	Brain Lower Grade Glioma	0.158	0.1086	9.7e-06	0.039	0.050	0.054	NA	0.048	2.4e-05	2.1e-06	9.0e-07	NA	3.5e-06
7	TCGA	Lung Adenocarcinoma	0.133	0.1110	8.1e-04	0.024	0.022	0.023	NA	0.026	6.5e-04	1.2e-03	9.4e-04	NA	4.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.4	0.9	-0.9	0.6	0.3	-0.6	1.2	0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.8	-0.3	-0.2	-0.3	0.2	0.7	0.5
Depressed Affect (Nagel 2018)	2.1	4.4	7.8	-2.0	2.8	0.0	-2.8	-0.2	-2.2	-2.5
Depression (Nagel 2018)	0.6	0.9	1.6	-1.3	1.2	-0.2	-1.1	-0.0	-0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.2	1.8	-1.0	-0.4	-1.0	0.2	1.2	1.0
Neuroticism (Nagel 2018)	0.9	2.1	6.9	-1.1	1.7	0.1	-2.6	0.3	-0.9	-1.6
Schizophrenia (2018)	0.1	0.2	0.5	0.3	0.3	-0.7	-0.7	0.7	0.0	-0.0
Schizophrenia vs Biploar Disorder	0.3	0.5	1.1	0.0	0.8	-0.3	-1.0	-0.1	-1.0	-0.6
Worry (Nagel 2018)	0.2	0.5	2.3	0.0	0.6	0.1	-1.5	0.6	0.3	-0.7
Alzheimer’s Disease (in mother)	0.3	0.3	1.5	-1.2	0.1	0.4	0.0	-0.8	-0.2	-0.1
Alzheimer’s Disease (in father)	0.8	0.9	4.1	0.5	-0.3	-2.0	0.7	-0.2	-1.1	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.6	-0.1	-0.6	0.6	-0.6	-0.9	-0.1
Crohns Disease (2017)	0.7	1.6	8.8	1.0	-0.6	-0.7	3.0	0.2	-0.6	-0.4
Irritable Bowel Disease (IBD)	0.4	1.1	3.1	0.7	-0.8	-1.8	1.7	-0.2	-0.2	0.5
Ulcerative Colitis (UC)	0.4	0.7	3.2	-0.0	-0.5	-1.8	0.3	-0.4	0.3	1.0
Major Depression (MDD)	0.9	1.0	4.0	1.3	-0.8	-0.6	2.0	-0.1	0.6	0.5
Reaction Time	0.2	0.3	0.9	0.5	-0.5	-0.2	0.4	-0.9	0.8	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.9	0.8	0.1	1.3	-1.4	0.5	0.4	0.3
Breast Cancer	2.5	6.1	13.5	-3.7	2.7	1.0	-2.4	-0.7	-2.5	-3.0
Ovarian Cancer	0.1	0.2	0.8	-0.6	0.2	0.2	0.9	-0.3	-0.1	-0.2
Prostate Cancer	0.3	0.4	1.1	0.7	-0.2	0.5	1.1	1.0	-0.1	0.5
Age at First Birth	0.5	0.7	2.2	0.1	-0.1	-1.5	-0.6	-0.7	-0.7	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.2	0.0	0.4	0.0	0.0	0.2	0.0	-0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.2	-0.0	-0.3	0.3	-0.4	0.3	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.0	0.2	-0.4	0.7	-0.1	-0.8	-0.7
Crohns Disease (2012)	0.9	1.4	5.0	2.0	-0.8	-0.3	2.2	0.3	0.3	0.2
Mean Putamen Volume	0.8	0.9	4.5	-1.1	0.7	0.7	-2.1	0.1	-0.1	-0.1
Fasting Glucose	0.6	0.8	3.5	0.4	0.5	-1.9	0.1	-0.1	-0.5	-1.1
HbA1C	0.8	0.9	1.6	1.3	-1.0	-1.1	1.1	-0.3	0.4	0.9
HDL Cholesterol	0.7	1.1	3.1	0.8	-1.4	1.1	0.3	-0.2	1.8	1.0
LDL Cholesterol	1.2	2.0	5.2	0.4	-1.6	-1.2	1.8	0.1	2.3	0.9
Lupus	1.0	1.5	3.3	1.5	-1.8	-1.1	0.9	-0.8	1.1	1.0
Neuroticism (2016)	0.7	1.0	2.3	-1.3	0.9	0.6	-0.7	-0.0	-1.5	-1.1
Primary Biliary Cirrhosis	3.1	4.4	10.9	2.7	-2.0	-0.2	3.3	1.0	2.1	1.8
Rheumatoid Arthritis	0.1	0.2	0.5	0.0	-0.4	0.7	0.5	0.3	0.3	0.1
Schizophrenia (2014)	0.1	0.2	0.7	0.8	-0.2	-0.7	-0.4	0.3	0.1	0.2
Triglycerides	1.3	2.1	6.4	-0.8	2.0	-0.1	-1.2	0.0	-2.5	-1.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.3	0.1	-0.3	0.8	0.4	-0.6	-0.4
Ulcerative Colitis	0.1	0.2	0.9	0.0	-0.4	-0.1	0.3	0.2	1.0	0.5
Blood Eosinophil Count	0.4	3.4	8.5	-2.9	2.2	0.8	-1.7	1.0	-2.2	-1.1
Blood Platelet Count	0.0	0.2	0.9	-0.8	0.2	0.2	0.1	-0.1	-0.2	1.0
Blood Red Count	0.1	0.6	1.6	0.5	-0.9	-0.4	1.3	-0.8	0.5	0.4
Blood White Count	0.0	0.4	0.8	0.2	0.2	0.6	0.9	0.7	-0.8	-0.4
Heel T-Score	0.6	4.9	9.9	-1.9	2.5	2.2	-3.1	1.7	-1.7	-1.8
BMI	0.2	0.9	2.4	0.9	0.6	-0.3	0.9	-0.5	-1.5	-1.3
Height	0.3	6.2	12.4	3.5	-3.0	-1.5	1.8	-1.0	2.6	2.9
Waist Hip Ratio (WHR)	1.3	5.7	11.2	3.3	-3.2	0.3	2.2	0.8	2.3	2.8
Systolic Blood Pressure	3.7	18.8	37.2	-6.1	5.1	2.1	-6.0	0.2	-3.8	-3.6
Smoking Status	0.0	0.1	0.2	-0.3	-0.3	-0.1	0.5	0.2	-0.3	-0.3
Allergy or Eczema	2.3	6.0	10.2	-2.7	3.1	0.8	-2.2	1.2	-3.2	-2.9
Cardiovascular Disease	1.3	4.1	7.4	-1.8	2.5	2.1	-2.7	0.8	-1.7	-2.1
Hypothyroidism (self reported)	0.1	0.2	0.7	0.5	0.3	-0.1	0.2	-0.3	-0.8	-0.2
Respiratory disease	4.1	9.1	13.8	-3.4	3.7	2.8	-2.6	2.2	-3.5	-2.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.4	0.3	0.0	-1.6	1.5	0.5	-0.8	-0.5
Lung FEV1/FVC ratio	3.5	17.8	29.2	4.3	-5.4	-3.5	3.2	-3.2	5.0	4.3
Lung FVC	0.5	2.6	5.1	0.4	-2.1	-0.8	-1.0	-1.8	2.3	1.8
Neuroticism	0.6	1.5	5.5	-0.6	1.1	-0.1	-2.3	0.2	-1.0	-1.5
Chronotype (morning person)	0.7	1.6	4.0	-1.0	1.2	-0.3	-0.3	-1.7	-1.3	-2.0
Hair Pigment	0.0	0.5	1.6	-0.6	0.8	1.3	-0.3	0.5	-0.6	-0.4
Tanning	0.1	0.7	1.5	-0.8	1.2	0.5	-0.6	0.6	-0.7	-1.0
Hand grip strength (left)	0.6	1.5	5.4	-1.7	0.9	-2.3	0.5	-0.4	-0.8	-0.7
Number of treatments/medications taken	0.4	0.7	1.7	1.3	-0.0	1.1	1.0	1.0	0.4	0.1
Average weekly spirits intake	0.4	0.5	1.0	-0.4	0.9	0.6	-0.7	0.3	-0.7	-1.0
Sensitivity / hurt feelings	0.2	0.3	0.7	0.6	-0.4	-0.6	-0.4	-0.8	0.6	-0.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.7	0.4	-1.1	-1.9	1.0	-0.3	1.1	1.2
Hearing difficulty/problems: Yes	3.7	5.6	11.3	2.0	-3.4	-0.3	2.9	-0.5	2.5	3.0
Relative age of first facial hair	0.1	0.2	0.4	0.3	-0.4	0.1	0.6	-0.4	-0.4	0.5
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	6.1	2.5	-1.6	0.8	1.9	0.4	2.2	1.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	0.4	-0.9	-0.3	0.0	-0.2	0.7	1.2
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.3	-0.4	0.7	-0.8	-0.2	0.8	0.8
Systolic blood pressure, automated reading	2.8	8.3	11.8	-3.4	3.4	3.3	-3.4	1.2	-1.7	-2.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.5	0.3	0.3	-1.2	0.3	0.2	-0.1	-0.0
Angina	0.7	0.9	1.6	0.1	0.8	1.2	0.8	1.2	-0.7	-1.3
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.5	0.2	-0.9	0.3	0.8	-0.4	0.1
Vitamin and mineral supplements	1.9	2.6	5.6	-1.9	1.7	1.0	-1.2	-0.5	-1.8	-2.4
Supplements: Zinc	0.6	0.7	2.1	0.2	-0.4	-1.4	0.2	-1.4	0.6	0.3
Medication: Co-codamol	0.2	0.2	0.5	-0.2	0.4	-0.4	0.5	-0.3	-0.7	-0.3
Medication: Metformin	1.5	2.2	6.0	1.7	-1.1	-2.2	2.5	0.3	0.2	-0.1
Diabetes (father)	1.0	1.3	2.5	-1.6	1.3	0.6	-0.6	-0.5	-1.6	-1.3
Diabetes (mother)	1.3	1.7	7.3	0.2	-0.4	1.7	2.7	0.3	-1.0	-0.3
Severe depression (siblings)	0.4	0.4	1.3	-0.2	-0.0	0.4	-0.0	1.0	1.1	0.6
Pack years adult smoking proportion	0.9	1.4	5.7	1.2	-0.5	0.9	2.4	1.1	0.2	0.3
Impedance of leg (right)	0.1	0.4	1.3	-0.0	-0.6	0.4	-0.2	-0.5	1.2	0.9
Leg fat-free mass (left)	0.2	1.0	3.4	1.9	-1.0	-0.1	1.5	-0.2	0.3	0.8
Trunk fat percentage	0.4	1.8	5.2	2.3	-1.3	0.4	1.9	0.2	1.1	0.7
Hand grip strength (right)	0.3	0.9	2.5	-1.5	0.4	-1.6	0.4	-0.8	-0.3	-0.4
Townsend deprivation index at recruitment	0.3	0.4	1.1	-1.1	0.4	-0.5	-0.4	0.5	-0.4	-0.8
Current tobacco smoking	0.3	0.5	2.5	-0.3	-0.1	0.1	1.6	0.6	-0.6	-0.6
Average weekly fortified wine intake	3.5	4.1	9.2	-1.9	3.0	0.4	-2.2	0.7	-2.1	-2.5
Maternal smoking around birth	0.7	1.0	2.5	-1.1	0.8	-0.0	0.6	-0.2	-1.4	-1.6
Fed-up feelings	2.6	4.8	6.9	-2.2	2.5	-1.4	-2.6	-1.0	-2.4	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.5	-1.4	0.7	-1.9	-0.2	-0.5	-1.4	-1.1
Relative age voice broke	1.1	1.6	5.5	-0.7	1.1	0.2	-0.5	-0.8	-2.3	-1.8
Taking other prescription medications	0.1	0.2	0.9	0.5	-0.2	0.3	0.9	0.0	0.2	-0.4
Age when periods started (menarche)	0.4	1.0	1.7	-1.2	0.2	-1.2	1.3	-0.6	-1.3	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.1	0.5	-0.1	-0.6	-0.2	-0.8	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.8	0.5	-0.0	-0.6	0.2	-1.0	-0.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	5.7	0.1	-1.3	-0.2	1.1	0.2	0.8	2.4
Qualifications: CSEs or equivalent	1.6	2.1	5.2	-0.8	1.7	1.4	-2.3	1.1	-1.5	-0.6
Serious illness, injury or assault to yourself	1.8	2.2	4.6	1.7	-1.7	-0.7	2.1	0.1	1.2	1.7
High blood pressure	0.7	1.9	3.7	-0.9	1.6	1.4	-1.5	0.9	-1.2	-1.9
Hayfever, allergic rhinitis or eczema	1.5	3.4	7.2	-2.0	2.4	0.6	-1.2	0.9	-2.7	-2.0
Multivitamins +/- minerals	1.1	1.4	3.5	1.3	-1.1	-0.9	0.5	1.0	1.1	1.9
Stomach or abdominal pain in last month	0.5	0.6	1.8	0.2	-1.0	-0.3	1.3	-0.7	-0.7	0.6
Supplements: Glucosamine	0.2	0.2	1.0	0.1	0.3	-0.7	0.2	-0.1	-1.0	-0.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.5	1.9	-1.1	-0.2	0.2	0.1	1.9	1.1
Medication: Atenolol	0.2	0.2	0.6	0.8	-0.4	0.0	0.8	0.2	-0.1	-0.6
Medication: Levothyroxine sodium	0.8	1.4	4.4	1.5	-0.6	2.1	0.4	0.4	1.0	1.0
Sitting height	0.4	2.6	5.2	1.6	-2.0	0.5	2.3	-0.3	1.8	1.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.9	-1.0	0.5	0.6	-0.3	0.1	0.1	-0.1
High blood pressure (mother)	1.7	2.4	5.6	-2.3	1.5	1.0	-2.4	0.1	-1.1	-1.1
Body mass index (BMI)	0.2	0.8	3.3	1.8	-0.4	0.4	1.4	0.5	-0.1	-0.2
Impedance of leg (left)	0.1	0.3	0.9	-0.4	-0.3	0.5	-0.1	-0.3	1.0	0.6
Leg predicted mass (left)	0.2	1.0	3.3	1.8	-1.0	-0.0	1.4	-0.2	0.2	0.8
Trunk fat mass	0.6	2.6	7.8	2.8	-1.6	0.4	2.1	0.2	1.3	1.1
Waist circumference	1.0	3.7	12.0	3.5	-1.7	1.2	2.4	1.1	1.2	1.1
Number of incorrect matches in round	1.7	2.8	5.2	2.2	-2.3	-0.6	0.9	-0.5	2.2	1.8
Past tobacco smoking	0.2	0.3	0.7	-0.4	0.7	0.6	0.2	-0.1	-0.8	-0.4
Alcohol usually taken with meals	1.4	2.2	8.1	1.1	-1.4	-2.9	0.7	-0.7	1.2	1.3
Nervous feelings	0.1	0.2	0.5	-0.3	-0.3	0.0	-0.7	-0.5	0.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.4	0.6	-0.5	-1.2	0.8	0.5	-0.0	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.2	-0.4	0.1	-0.5	-0.6	0.3	0.1
Hair/balding pattern: Pattern 2	3.4	4.3	7.3	-1.9	2.7	1.7	-2.7	0.6	-1.8	-2.3
Had menopause	0.4	0.5	1.8	1.0	-0.7	0.2	0.0	0.4	1.4	0.1
Had other major operations	0.4	0.5	2.0	1.4	-0.4	-0.5	0.6	0.9	0.3	0.2
Forced vital capacity (FVC)	0.6	2.2	4.3	0.7	-2.1	-1.4	0.6	-2.0	1.3	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	-0.9	0.7	1.0	-0.3	0.5	-1.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	-0.5	-0.5	-1.0	0.7	0.4	1.6	0.9
Qualifications: None of the above	0.7	1.4	4.0	-0.5	1.2	2.0	-1.3	1.3	-0.4	-0.8
Financial difficulties in last 2 years	0.7	1.0	1.9	-1.2	0.5	-1.0	0.2	-0.9	-1.1	-1.4
Mouth/teeth dental problems	2.5	3.8	8.7	-3.0	2.6	0.3	-2.3	0.3	-1.8	-1.5
Heart attack	2.0	2.6	5.2	-1.8	1.7	-0.8	-1.2	-0.7	-2.3	-2.0
Allergy	3.3	7.6	17.0	2.7	-3.4	-1.7	1.6	-1.7	4.1	2.9
Pain all over the body in last month	1.1	1.2	4.4	1.7	-0.4	-0.2	2.1	0.8	0.2	0.5
Diabetes (self-reported)	0.3	0.5	1.1	1.1	-0.7	-0.9	1.0	0.3	0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.2	-1.1	1.5	0.6	-0.4	1.2	-1.5	-1.0
Medication: Ramipril	0.7	0.9	2.9	-0.5	1.0	-0.5	-0.5	-0.1	-1.3	-1.7
Medication: Simvastatin	0.6	0.9	4.0	0.7	0.6	2.0	-0.1	1.2	0.1	-0.1
Fluid intelligence score	0.1	0.2	1.1	0.1	0.1	0.6	-1.1	0.3	-0.0	-0.1
Illnesses of siblings	0.3	0.4	1.5	-0.5	0.3	-0.9	-1.2	-0.1	0.5	0.1
Neuroticism score	0.4	0.9	4.8	-0.1	0.5	-0.5	-2.2	-0.2	-0.3	-0.8
Weight	0.5	2.4	7.6	2.8	-1.6	-0.1	2.1	-0.0	1.1	1.0
Impedance of arm (right)	0.5	2.5	6.1	1.0	-2.1	0.2	1.0	-0.9	2.5	2.1
Arm fat percentage (right)	0.6	2.2	6.8	2.6	-1.5	0.8	2.0	0.1	1.1	1.0
Trunk fat-free mass	0.3	1.5	4.5	2.1	-1.4	-0.1	1.4	-0.3	0.7	1.3
Hip circumference	0.4	1.5	5.2	2.3	-0.8	0.5	2.0	0.4	0.5	0.4
Time employed in main current job	0.3	0.4	1.1	0.5	-0.6	-0.7	0.2	0.2	1.0	0.7
Alcohol intake versus 10 years previously	0.6	0.9	4.2	0.2	-0.8	-0.7	2.0	0.3	0.6	0.6
Father’s age at death	1.2	1.6	4.7	0.9	-1.3	-2.2	0.5	-1.6	1.0	0.6
Worrier / anxious feelings	1.4	2.6	6.1	2.5	-2.0	-0.9	0.5	-0.2	2.2	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	-0.5	0.7	0.6	-0.2	0.2	-1.3	-1.2
Falls in the last year	0.7	1.0	2.1	0.6	-1.4	-0.7	1.2	-0.7	0.9	1.1
Hair/balding pattern: Pattern 3	0.8	1.1	4.4	0.5	-1.1	-2.1	0.5	-0.8	0.4	1.0
Number of live births	0.4	0.6	2.0	-0.4	0.4	-1.4	-0.3	-0.7	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	10.5	1.7	-3.2	-2.5	1.4	-2.9	2.3	2.9
Pulse rate	3.5	5.9	17.9	2.5	-2.7	-2.3	4.2	-0.5	1.6	1.4
Happiness	2.1	2.5	5.7	1.1	-1.9	-0.7	2.4	-0.6	1.8	1.8
Noisy workplace	0.3	0.4	1.0	-0.3	0.5	0.9	1.0	0.5	-0.3	-0.4
Qualifications: A levels/AS levels or equivalent	1.5	3.4	8.2	1.3	-2.3	0.7	0.8	-0.6	2.6	2.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.5	0.5	-0.0	-0.2	0.9	1.2	0.6	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	1.1	-0.8	-1.2	-0.0	-0.6	0.5	-0.1
Asthma	3.1	6.1	9.2	-2.1	3.0	2.6	-1.5	2.6	-3.0	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.7	0.0	0.1	0.4	0.1	0.1	-0.9	0.2
Medication: Cholesterol lowering	0.1	0.2	0.7	0.5	0.0	0.3	-0.0	0.6	0.9	0.1
Depression (self-reported)	0.7	0.8	2.0	0.6	-0.9	-1.4	1.3	-0.6	0.7	0.5
Medication: Lansoprazole	0.4	0.5	1.2	0.6	0.7	0.4	0.4	0.4	-1.1	-0.8
Prospective memory result	1.0	1.3	2.1	-0.2	1.5	1.4	-0.4	1.1	-1.2	-1.3
Lung cancer (father)	0.6	0.7	1.6	-0.5	1.2	0.6	-0.4	0.2	-1.0	-1.3
Illnesses of mother	0.3	0.4	1.7	0.2	0.2	-1.3	0.2	-0.0	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	9.3	1.5	-3.1	-1.8	1.3	-2.8	2.5	3.0
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.6	0.4	-0.0	-0.3	0.3	0.2	-0.0
Impedance of arm (left)	0.4	1.8	5.7	0.5	-1.7	0.3	0.4	-0.9	2.4	1.6
Arm fat mass (right)	0.5	2.1	7.0	2.6	-1.3	0.7	2.0	0.2	0.8	0.8
Trunk predicted mass	0.3	1.5	4.5	2.1	-1.4	-0.2	1.4	-0.2	0.7	1.3
Standing height	0.4	4.2	6.9	2.3	-2.6	-0.7	1.5	-0.9	2.5	2.6
Length of working week for main job	0.6	0.7	2.0	1.4	-0.4	0.6	0.2	1.2	-0.4	0.8
Exposure to tobacco smoke at home	0.7	0.8	2.6	0.4	-0.4	0.8	1.6	1.0	-0.9	-0.7
Breastfed as a baby	1.2	1.5	5.1	1.1	-1.2	0.9	0.1	0.4	2.3	1.3
Tense / ‘highly strung’	0.3	0.5	1.3	1.1	-0.9	-0.5	0.6	0.1	0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.5	0.0	-0.8	-1.6	0.2	-1.4	0.6	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	-0.6	0.8	1.0	0.1	1.2	-0.2	-0.4
Birth weight of first child	0.8	1.4	3.2	1.8	-1.0	-1.4	1.0	-1.1	0.9	0.6
Peak expiratory flow (PEF)	0.4	1.0	2.3	0.4	-1.2	-1.5	0.3	-1.5	0.6	0.8
Pulse wave reflection index	0.2	0.3	1.1	-0.5	0.5	0.5	-1.1	-0.2	-0.1	-0.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.0	-1.6	1.7	-0.2	0.1	0.3	-1.6	-1.7
Loud music exposure frequency	0.6	0.7	2.0	0.9	-0.7	0.8	1.4	-0.0	0.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.8	-1.3	0.7	1.1	-0.6	0.3	-0.5	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	1.1	-0.7	0.6	0.9	0.1	0.4	0.5
Blood clot in the leg (DVT)	1.5	1.9	5.6	-1.0	1.2	-0.0	-1.6	-0.5	-2.4	-1.5
Medication: Paracetamol	1.0	1.6	3.3	1.8	-1.5	-0.2	1.8	-0.2	0.9	1.4
Headache pain in last month	1.4	2.5	7.4	2.7	-1.5	-1.6	0.4	0.4	1.5	1.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	-0.5	0.2	0.6	-0.5	-0.2	-0.1	0.2
Glaucoma (self-reported)	0.3	0.3	0.8	-0.7	0.7	-0.4	-0.5	0.2	-0.9	-0.3
Gout (self-reported)	0.8	1.0	1.8	-1.3	0.9	-1.3	-1.1	0.3	-1.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.3	1.4	-0.4	1.5	0.4	0.4	0.6	0.8
Medication: Amlodipine	1.8	2.5	4.4	-1.4	1.9	2.1	-1.4	1.6	-1.1	-1.3
Medication: Ventolin 100micrograms inhaler	3.1	4.0	7.1	-2.7	2.7	2.2	-1.4	1.0	-2.0	-1.4
Birth weight	2.1	4.5	8.7	2.7	-2.6	0.7	1.0	-0.4	2.6	2.9
Chronic bronchitis/emphysema (mother)	3.7	4.4	9.6	2.0	-3.1	-0.5	1.5	-1.2	2.9	2.2
High blood pressure (siblings)	0.1	0.2	1.1	-0.3	0.2	1.1	-0.3	0.3	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	2.8	0.4	-1.5	-0.5	0.3	-1.4	1.3	1.7
Body fat percentage	0.4	1.6	5.4	2.3	-1.1	0.7	1.6	0.3	0.9	0.5
Leg fat percentage (right)	0.4	1.4	6.3	2.5	-0.9	0.3	1.5	0.2	0.5	0.2
Arm fat-free mass (right)	0.1	0.3	1.3	1.1	-0.1	0.3	0.6	0.1	-0.3	-0.0
Exposure to tobacco smoke outside home	1.4	1.9	8.7	1.1	-1.1	0.4	3.0	1.2	0.8	0.4
Comparative body size at age 10	0.9	2.4	5.5	2.2	-2.0	0.6	0.3	-0.7	2.3	1.3
Number of full brothers	1.2	1.5	3.0	1.6	-1.3	0.1	1.7	1.2	-0.1	1.4
Worry too long after embarrassment	0.9	1.4	6.2	-0.4	0.9	1.0	-2.5	1.2	-0.5	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	-0.2	0.6	0.3	-0.7	0.2	-0.7	-0.9
Wheeze or whistling in the chest in last year	0.9	1.7	3.5	-1.3	1.4	1.1	-0.8	1.9	-1.2	-1.1
Number of children fathered	0.2	0.3	0.8	-0.6	0.7	0.0	-0.0	0.1	-0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.6	1.6	-1.2	-1.0	-0.2	0.2	0.9	1.3
Age at first live birth	0.9	1.7	3.1	1.2	-1.8	-0.9	0.9	-1.6	1.3	1.1
Pulse wave peak to peak time	0.1	0.2	0.3	0.5	-0.6	-0.3	0.4	-0.6	-0.1	0.1
Health satisfaction	0.5	0.7	1.6	-0.7	0.6	-0.2	1.2	-0.1	-1.3	-0.9
Shortness of breath walking on level ground	3.6	4.3	7.5	-2.2	2.7	1.4	-1.1	0.9	-2.6	-2.7
Qualifications: College or University degree	0.3	0.9	2.6	0.7	-1.0	0.3	0.3	-0.6	1.2	1.6
Eye problems/disorders: None of the above	0.3	0.3	1.1	-0.3	0.3	1.0	0.1	0.3	-0.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.5	1.0	-1.2	-1.1	1.6	-0.3	-0.1	0.4
Emphysema/chronic bronchitis	0.7	0.7	2.8	-1.7	0.8	-1.1	-0.7	0.1	0.0	-0.3
Medication for pain relief, constipation, heartburn	1.2	2.1	6.9	-2.6	1.4	-0.8	-1.5	-0.8	-0.8	-1.3
Neck or shoulder pain in last month	0.6	0.8	2.8	0.7	-1.1	-0.3	1.7	0.3	-0.7	0.8
Medication: Blood pressure	0.3	0.5	1.4	-0.4	0.3	-0.8	-0.3	0.1	-1.0	-1.2
Angina (self-reported)	0.5	0.7	1.5	0.3	0.5	0.7	1.0	1.1	-0.6	-1.2
Migraine (self-reported)	0.4	0.5	1.1	1.0	-0.4	-0.8	0.0	0.9	0.8	0.4
Medication: Ibuprofen	0.2	0.2	0.5	0.1	-0.2	0.3	0.6	-0.4	-0.7	0.4
Medication: Allopurinol	0.4	0.5	2.2	-0.2	0.3	-1.5	-0.7	0.2	-0.9	0.3
Medication: Omeprazole	0.3	0.4	1.0	1.0	-0.4	-0.1	0.8	-0.7	-0.1	-0.4
Medication: Seretide 50 evohaler	1.1	1.2	3.6	-0.4	0.8	1.9	-0.5	1.4	-1.0	-1.0
Mean time to correctly identify matches	0.4	0.7	1.4	0.7	-0.9	-0.9	0.4	-1.2	1.2	0.3
Heart disease (mother)	0.4	0.4	1.1	0.8	-0.5	-0.4	1.1	-0.1	0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.3	-1.0	1.4	0.2	-0.3	1.1	-1.8	-0.8
Whole body fat mass	0.4	1.8	6.7	2.6	-1.1	1.0	1.7	0.3	0.8	0.6
Leg fat mass (right)	0.4	1.4	6.0	2.4	-0.8	0.6	1.7	0.1	0.3	0.3
Arm predicted mass (right)	0.1	0.3	1.5	1.2	-0.2	0.0	0.7	0.1	-0.3	-0.0
Pulse rate, automated reading	2.4	7.6	18.2	4.0	-3.3	-1.8	4.3	0.0	1.4	1.9
Alcohol intake frequency.	0.3	0.7	1.2	-0.7	0.5	-1.1	0.9	-0.3	-1.0	-1.1
Comparative height size at age 10	1.0	5.5	11.5	3.0	-2.6	0.7	1.7	0.4	3.4	2.8
Number of full sisters	0.6	0.7	2.6	1.2	0.1	0.7	0.4	1.6	0.0	0.5
Suffer from ‘nerves’	0.5	0.8	3.9	-0.6	0.6	-0.5	-2.0	0.4	-0.0	-0.5
Overall health rating	0.4	0.9	3.7	0.8	-0.5	0.7	1.9	1.0	0.5	0.1
Chest pain or discomfort	0.4	0.5	1.1	0.6	-0.0	1.0	1.1	0.8	-0.2	-0.7
Had major operations	0.8	0.9	2.2	1.2	-0.9	-0.2	-1.0	0.1	1.0	1.5
Age at last live birth	1.2	1.8	4.1	0.3	-1.3	-2.0	0.8	-1.9	1.2	1.1
Family relationship satisfaction	0.8	0.9	2.6	-0.2	-0.8	0.5	0.5	-0.3	1.6	1.6
Leg pain on walking	0.9	1.1	2.7	-0.1	0.5	1.6	1.3	0.9	-1.0	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.0	-0.1	-0.6	-1.0	0.6	0.1	0.6	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.7	0.2	0.8	0.7	0.4	0.5	-1.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.8	0.0	-0.3	0.4	-1.3	-0.9	0.1	0.5
Medication: Aspirin	0.4	0.5	1.3	1.1	-0.1	0.8	0.4	1.0	0.5	-0.1
Supplements: Vitamin C	0.4	0.4	0.9	0.5	-0.6	-0.9	-0.4	-0.6	0.5	0.9
Knee pain experienced in last month	2.6	4.0	7.2	2.2	-2.7	-0.2	2.1	0.5	1.9	2.7
Hypertension (Self-reported)	1.1	3.0	4.8	-1.3	2.0	1.9	-1.7	1.4	-1.5	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.6	0.5	-0.1	-0.6	-1.3	-0.5	-0.3	0.0
Illnesses of father: Heart disease	0.3	0.5	1.1	0.4	-0.4	-1.0	0.9	-0.3	-0.9	-0.4
Illnesses of siblings: Diabetes	1.0	1.3	4.5	1.3	-1.1	-0.8	2.1	-0.0	-0.0	1.0
Smoking status: Previous	0.2	0.3	1.4	0.1	-0.3	-0.1	-1.2	0.2	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	0.0	-0.0	-0.0	0.5	0.3	-0.4	0.4
Whole body fat-free mass	0.2	1.1	3.9	2.0	-1.0	-0.1	1.4	-0.1	0.4	0.9
Leg fat-free mass (right)	0.1	0.6	2.1	1.4	-0.6	-0.0	1.3	-0.0	-0.0	0.5
Arm fat percentage (left)	0.4	1.5	5.2	2.3	-1.2	0.8	1.6	0.1	0.9	0.6
Average weekly red wine intake	0.3	0.5	1.7	0.1	-0.1	-1.3	0.6	-0.6	-0.8	-0.2
Handedness (chirality/laterality): Left-handed	2.1	2.6	7.4	1.1	-1.6	-2.7	1.9	0.5	0.7	1.6
Mood swings	0.4	0.8	2.2	1.4	-0.7	-1.5	0.2	-0.6	0.3	0.3
Loneliness, isolation	0.7	1.0	3.2	-1.4	1.0	-0.1	-1.8	-0.2	-0.7	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	2.3	-0.8	1.5	0.3	0.3	0.2	-1.0	-1.5
Ever had bowel cancer screening	1.4	1.7	4.5	1.3	-1.1	1.4	0.5	0.8	2.1	1.3
Diabetes diagnosed by doctor	0.9	1.5	4.2	1.6	-1.2	-1.2	2.1	0.2	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.9	-0.3	0.3	-2.2	-0.1	-0.7	-1.2	-0.5
Friendships satisfaction	1.6	2.0	3.5	0.9	-1.7	-0.4	1.9	-0.5	1.8	1.7
Qualifications: nursing, teaching	0.3	0.4	1.8	-0.0	-0.5	-1.3	0.4	-1.0	-0.0	-0.1
Commuting to job workplace: Walk	0.4	0.4	1.8	-0.4	-0.2	-0.4	0.9	-1.4	0.3	-0.1
Eye problems/disorders: Cataract	0.8	0.9	2.7	0.1	-1.2	-0.6	0.8	-0.6	1.6	1.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.5	1.0	-1.9	0.8	1.5	-0.3	1.3	1.0
Medication for cholesterol	1.6	2.5	4.3	1.0	-2.1	-1.4	1.3	-1.8	1.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	0.5	-0.4	0.6	-0.7	-0.7	0.5	0.3
Back pain experienced in last month	1.1	1.6	9.7	0.4	0.0	3.1	0.8	0.6	0.0	0.5
Mineral and other dietary supplements	0.4	0.5	1.2	-1.1	0.4	0.5	-0.7	0.1	-0.6	-1.0
Breast cancer (self-reported)	1.6	1.9	3.6	1.7	-1.9	0.8	1.6	0.1	1.5	1.3
Asthma (self-reported)	3.5	6.9	10.2	-2.2	3.2	2.7	-1.9	2.6	-3.2	-2.3
Osteoporosis (self-reported)	1.6	2.0	3.7	1.1	-1.9	-1.3	1.1	-0.8	1.9	1.4
Osteoarthritis (self-reported)	1.0	1.3	3.8	0.9	-1.3	-2.0	0.9	-1.2	0.6	-0.5
Medication: Aspirin	0.2	0.2	0.6	0.7	0.0	0.5	0.1	0.7	0.4	-0.2
Medication: Gliclazide	1.1	1.3	2.7	-0.9	0.9	-1.4	0.6	-0.1	-1.6	-1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	0.3	-0.5	0.0	0.4	0.1	1.4	1.3
Smoking status: Current	0.4	0.6	2.9	-0.4	0.0	0.4	1.7	0.6	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.5	-0.2	-1.0	-0.3	-0.2	-1.9	1.1	1.4
Whole body water mass	0.2	1.1	4.0	2.0	-1.0	-0.1	1.3	-0.0	0.4	0.9
Leg predicted mass (right)	0.1	0.7	2.4	1.5	-0.7	-0.0	1.3	-0.0	0.1	0.6
Arm fat mass (left)	0.4	1.8	6.1	2.5	-1.2	0.6	1.9	0.2	0.6	0.6
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	0.8	0.3	1.2	0.4	0.9	-0.2	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.1	0.9	0.6	-1.0	-0.2	0.4	-0.1	-0.1
Miserableness	1.5	2.6	9.2	-1.1	1.6	-0.2	-3.0	-0.6	-1.4	-1.7
Guilty feelings	0.4	0.6	1.3	0.4	-1.1	-0.7	-0.6	-0.7	1.2	0.4
Wears glasses or contact lenses	1.1	1.2	3.2	1.4	-1.1	-0.8	0.3	0.5	1.8	1.2
Ever taken oral contraceptive pill	0.3	0.4	1.4	-0.1	-0.5	-0.8	1.2	0.1	0.1	0.5
Hearing aid user	0.4	0.4	1.3	0.1	-0.3	-0.9	-0.5	0.6	1.1	0.5
Mother’s age at death	1.1	1.4	6.6	-0.3	1.2	0.4	-2.6	-0.0	-0.5	-1.1
Financial situation satisfaction	0.3	0.3	0.7	-0.5	-0.8	-0.8	0.4	-0.5	0.3	0.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.9	-0.8	1.3	0.7	-0.5	0.4	-1.3	-2.0
Commuting to job workplace: Public transport	0.1	0.1	0.4	-0.1	-0.2	0.2	-0.6	-0.1	0.2	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-0.4	0.8	0.5	-1.1	0.6	-0.8	-0.4
Medication: Blood pressure	1.6	3.0	4.5	-1.4	2.1	1.6	-2.0	1.0	-1.9	-2.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	1.3	-1.4	0.1	1.1	-1.3	0.2	0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.9	1.3	-0.9	0.6	0.2	-0.6	2.0	1.7
High cholesterol (Self-reported)	0.6	1.1	4.2	0.5	1.0	2.1	-0.9	1.2	0.1	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.4	-0.8	0.7	0.5	-1.2	0.8	-0.0	-0.1
Medication: Paracetamol	0.8	1.3	3.6	1.4	-1.4	0.2	1.9	-0.7	0.5	0.8
Medication: Lisinopril	0.5	0.6	1.7	-1.0	0.7	0.0	-1.3	0.5	-1.0	-0.1
Medication: Atorvastatin	0.4	0.4	1.3	0.8	-1.0	0.1	0.3	-0.2	1.1	0.2
Illnesses of father: High blood pressure	0.2	0.2	0.7	-0.0	-0.4	0.8	-0.0	0.3	-0.4	0.4
Alcohol drinker status: Never	1.1	1.3	3.7	-0.8	0.4	-1.9	-0.4	-1.2	-1.2	-1.3
Ever smoked	0.3	0.5	1.2	0.5	-0.8	-1.0	0.4	0.5	1.1	0.5
Basal metabolic rate	0.3	1.5	5.0	2.2	-1.2	0.0	1.6	-0.1	0.6	1.0
Leg fat percentage (left)	0.4	1.4	5.8	2.4	-0.8	0.3	1.7	0.4	0.4	0.1
Arm fat-free mass (left)	0.2	1.0	3.5	1.9	-0.8	-0.3	1.5	0.3	0.0	0.6
Number of operations (self-reported)	1.8	2.6	6.4	2.5	-2.0	-1.2	1.7	0.0	1.4	1.4
Average weekly beer plus cider intake	0.3	0.5	1.3	-0.4	0.3	0.8	1.2	0.2	-0.9	-0.5
Irritability	0.7	1.2	2.7	1.6	-1.2	-1.5	1.1	0.0	0.4	0.6
Risk taking	0.8	1.1	4.8	-1.2	0.9	-0.3	-0.4	0.4	-2.2	-0.7
Ever had prostate specific antigen (PSA) test	1.6	1.8	4.5	1.2	-1.8	-0.5	0.2	0.5	1.8	2.1
Fractured/broken bones in last 5 years	1.2	1.5	4.2	-0.2	-1.4	-1.1	2.1	-1.7	0.4	-0.1
Age started oral contraceptive pill	0.2	0.3	0.5	0.7	-0.5	0.4	0.6	-0.5	0.7	0.1
Diastolic blood pressure, automated reading	0.9	2.7	4.4	-2.1	2.1	1.3	-1.6	0.6	-1.7	-1.7
Ever depressed for a whole week	0.8	1.0	2.8	0.3	-0.9	-1.7	0.7	-0.3	1.4	0.9
Unable to work because of sickness or disability	0.2	0.3	0.7	0.7	-0.9	-0.3	0.4	-0.2	0.5	0.7
Commuting to job workplace: Cycle	1.3	1.6	4.4	0.6	-1.0	0.9	-0.5	0.2	2.0	2.1
Myopia	0.4	0.6	2.9	-0.4	0.6	1.7	-0.9	0.5	-0.3	-0.2
Vascular/heart problems diagnosed by doctor	1.2	3.2	5.7	1.5	-2.2	-1.5	1.8	-1.1	1.6	2.4
Cholesterol lowering medication	0.6	0.9	4.0	0.5	0.8	2.0	-0.2	1.1	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	1.0	-1.1	-0.4	0.8	-0.9	0.4	0.1
Pain experienced in last month	3.4	5.7	11.6	-3.4	2.5	-0.8	-2.6	-1.1	-1.8	-3.1
Supplements: Calcium	1.2	1.3	3.1	1.1	-1.0	-1.6	1.8	-0.8	0.3	0.6
Basal cell carcinoma (self-reported)	1.3	1.6	3.6	0.7	-1.3	-1.7	0.1	0.0	1.9	1.5
Heart attack/myocardial infarction (self-reported)	1.7	2.1	4.9	-1.5	1.6	-0.6	-1.1	-0.3	-2.2	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	7.6	-1.3	1.5	-0.1	-1.8	-0.8	-2.8	-1.9
Heart disease (siblings)	0.8	1.0	2.0	0.7	0.4	1.4	1.3	1.0	-1.0	-0.7
Alcohol drinker status: Previous	0.1	0.1	0.4	0.3	-0.3	-0.6	0.6	0.1	0.4	0.0
Pack years of smoking	1.2	1.7	5.7	1.7	-0.6	1.0	2.4	1.2	0.4	0.4
Impedance of whole body	0.1	0.7	2.3	-0.2	-0.9	0.4	-0.0	-0.6	1.5	1.1
Leg fat mass (left)	0.4	1.5	5.6	2.4	-0.8	0.7	1.8	0.3	0.3	0.2
Arm predicted mass (left)	0.2	1.0	3.5	1.9	-0.9	-0.1	1.5	0.2	0.2	0.7