Hub : Genes

DNAJC9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.015 0.0110 8.8e-03 0.020 0.008 0.018 0.010 0.012 1.5e-03 3.0e-02 2.5e-03 1.9e-02 1.0e-02
2 GTEx Brain Cerebellar Hemisphere 0.155 0.1040 6.1e-03 0.071 NA 0.068 NA 0.083 7.0e-03 NA 8.3e-03 NA 3.8e-03
3 GTEx Heart Left Ventricle 0.363 0.0979 2.0e-03 -0.005 NA -0.005 NA -0.004 8.0e-01 NA 9.1e-01 NA 5.9e-01
4 GTEx Skin Sun Exposed Lower leg 0.053 0.0460 1.7e-03 0.002 NA 0.014 NA 0.013 2.3e-01 NA 2.1e-02 NA 2.5e-02
5 ROSMAP Brain Pre-frontal Cortex 0.306 0.0677 3.6e-06 -0.002 0.056 0.022 0.071 0.000 6.0e-01 9.8e-08 7.2e-04 1.8e-09 3.6e-01
6 TCGA Brain Lower Grade Glioma 0.158 0.1086 9.7e-06 0.039 0.050 0.054 NA 0.048 2.4e-05 2.1e-06 9.0e-07 NA 3.5e-06
7 TCGA Lung Adenocarcinoma 0.133 0.1110 8.1e-04 0.024 0.022 0.023 NA 0.026 6.5e-04 1.2e-03 9.4e-04 NA 4.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 1.4 0.9 -0.9 0.6 0.3 -0.6 1.2 0.7
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 0.8 -0.3 -0.2 -0.3 0.2 0.7 0.5
Depressed Affect (Nagel 2018) 2.1 4.4 7.8 -2.0 2.8 0.0 -2.8 -0.2 -2.2 -2.5
Depression (Nagel 2018) 0.6 0.9 1.6 -1.3 1.2 -0.2 -1.1 -0.0 -0.9 -0.9
Intelligence (Savage-Jansen 2018) 0.4 1.1 3.2 1.8 -1.0 -0.4 -1.0 0.2 1.2 1.0
Neuroticism (Nagel 2018) 0.9 2.1 6.9 -1.1 1.7 0.1 -2.6 0.3 -0.9 -1.6
Schizophrenia (2018) 0.1 0.2 0.5 0.3 0.3 -0.7 -0.7 0.7 0.0 -0.0
Schizophrenia vs Biploar Disorder 0.3 0.5 1.1 0.0 0.8 -0.3 -1.0 -0.1 -1.0 -0.6
Worry (Nagel 2018) 0.2 0.5 2.3 0.0 0.6 0.1 -1.5 0.6 0.3 -0.7
Alzheimer’s Disease (in mother) 0.3 0.3 1.5 -1.2 0.1 0.4 0.0 -0.8 -0.2 -0.1
Alzheimer’s Disease (in father) 0.8 0.9 4.1 0.5 -0.3 -2.0 0.7 -0.2 -1.1 -0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 -0.6 -0.1 -0.6 0.6 -0.6 -0.9 -0.1
Crohns Disease (2017) 0.7 1.6 8.8 1.0 -0.6 -0.7 3.0 0.2 -0.6 -0.4
Irritable Bowel Disease (IBD) 0.4 1.1 3.1 0.7 -0.8 -1.8 1.7 -0.2 -0.2 0.5
Ulcerative Colitis (UC) 0.4 0.7 3.2 -0.0 -0.5 -1.8 0.3 -0.4 0.3 1.0
Major Depression (MDD) 0.9 1.0 4.0 1.3 -0.8 -0.6 2.0 -0.1 0.6 0.5
Reaction Time 0.2 0.3 0.9 0.5 -0.5 -0.2 0.4 -0.9 0.8 0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.9 0.8 0.1 1.3 -1.4 0.5 0.4 0.3
Breast Cancer 2.5 6.1 13.5 -3.7 2.7 1.0 -2.4 -0.7 -2.5 -3.0
Ovarian Cancer 0.1 0.2 0.8 -0.6 0.2 0.2 0.9 -0.3 -0.1 -0.2
Prostate Cancer 0.3 0.4 1.1 0.7 -0.2 0.5 1.1 1.0 -0.1 0.5
Age at First Birth 0.5 0.7 2.2 0.1 -0.1 -1.5 -0.6 -0.7 -0.7 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.2 0.0 -0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 0.2 -0.0 -0.3 0.3 -0.4 0.3 0.3
Coronary Artery Disease (CAD) 0.2 0.2 0.6 0.0 0.2 -0.4 0.7 -0.1 -0.8 -0.7
Crohns Disease (2012) 0.9 1.4 5.0 2.0 -0.8 -0.3 2.2 0.3 0.3 0.2
Mean Putamen Volume 0.8 0.9 4.5 -1.1 0.7 0.7 -2.1 0.1 -0.1 -0.1
Fasting Glucose 0.6 0.8 3.5 0.4 0.5 -1.9 0.1 -0.1 -0.5 -1.1
HbA1C 0.8 0.9 1.6 1.3 -1.0 -1.1 1.1 -0.3 0.4 0.9
HDL Cholesterol 0.7 1.1 3.1 0.8 -1.4 1.1 0.3 -0.2 1.8 1.0
LDL Cholesterol 1.2 2.0 5.2 0.4 -1.6 -1.2 1.8 0.1 2.3 0.9
Lupus 1.0 1.5 3.3 1.5 -1.8 -1.1 0.9 -0.8 1.1 1.0
Neuroticism (2016) 0.7 1.0 2.3 -1.3 0.9 0.6 -0.7 -0.0 -1.5 -1.1
Primary Biliary Cirrhosis 3.1 4.4 10.9 2.7 -2.0 -0.2 3.3 1.0 2.1 1.8
Rheumatoid Arthritis 0.1 0.2 0.5 0.0 -0.4 0.7 0.5 0.3 0.3 0.1
Schizophrenia (2014) 0.1 0.2 0.7 0.8 -0.2 -0.7 -0.4 0.3 0.1 0.2
Triglycerides 1.3 2.1 6.4 -0.8 2.0 -0.1 -1.2 0.0 -2.5 -1.4
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.7 -0.3 0.1 -0.3 0.8 0.4 -0.6 -0.4
Ulcerative Colitis 0.1 0.2 0.9 0.0 -0.4 -0.1 0.3 0.2 1.0 0.5
Blood Eosinophil Count 0.4 3.4 8.5 -2.9 2.2 0.8 -1.7 1.0 -2.2 -1.1
Blood Platelet Count 0.0 0.2 0.9 -0.8 0.2 0.2 0.1 -0.1 -0.2 1.0
Blood Red Count 0.1 0.6 1.6 0.5 -0.9 -0.4 1.3 -0.8 0.5 0.4
Blood White Count 0.0 0.4 0.8 0.2 0.2 0.6 0.9 0.7 -0.8 -0.4
Heel T-Score 0.6 4.9 9.9 -1.9 2.5 2.2 -3.1 1.7 -1.7 -1.8
BMI 0.2 0.9 2.4 0.9 0.6 -0.3 0.9 -0.5 -1.5 -1.3
Height 0.3 6.2 12.4 3.5 -3.0 -1.5 1.8 -1.0 2.6 2.9
Waist Hip Ratio (WHR) 1.3 5.7 11.2 3.3 -3.2 0.3 2.2 0.8 2.3 2.8
Systolic Blood Pressure 3.7 18.8 37.2 -6.1 5.1 2.1 -6.0 0.2 -3.8 -3.6
Smoking Status 0.0 0.1 0.2 -0.3 -0.3 -0.1 0.5 0.2 -0.3 -0.3
Allergy or Eczema 2.3 6.0 10.2 -2.7 3.1 0.8 -2.2 1.2 -3.2 -2.9
Cardiovascular Disease 1.3 4.1 7.4 -1.8 2.5 2.1 -2.7 0.8 -1.7 -2.1
Hypothyroidism (self reported) 0.1 0.2 0.7 0.5 0.3 -0.1 0.2 -0.3 -0.8 -0.2
Respiratory disease 4.1 9.1 13.8 -3.4 3.7 2.8 -2.6 2.2 -3.5 -2.7
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.4 0.3 0.0 -1.6 1.5 0.5 -0.8 -0.5
Lung FEV1/FVC ratio 3.5 17.8 29.2 4.3 -5.4 -3.5 3.2 -3.2 5.0 4.3
Lung FVC 0.5 2.6 5.1 0.4 -2.1 -0.8 -1.0 -1.8 2.3 1.8
Neuroticism 0.6 1.5 5.5 -0.6 1.1 -0.1 -2.3 0.2 -1.0 -1.5
Chronotype (morning person) 0.7 1.6 4.0 -1.0 1.2 -0.3 -0.3 -1.7 -1.3 -2.0
Hair Pigment 0.0 0.5 1.6 -0.6 0.8 1.3 -0.3 0.5 -0.6 -0.4
Tanning 0.1 0.7 1.5 -0.8 1.2 0.5 -0.6 0.6 -0.7 -1.0
Hand grip strength (left) 0.6 1.5 5.4 -1.7 0.9 -2.3 0.5 -0.4 -0.8 -0.7
Number of treatments/medications taken 0.4 0.7 1.7 1.3 -0.0 1.1 1.0 1.0 0.4 0.1
Average weekly spirits intake 0.4 0.5 1.0 -0.4 0.9 0.6 -0.7 0.3 -0.7 -1.0
Sensitivity / hurt feelings 0.2 0.3 0.7 0.6 -0.4 -0.6 -0.4 -0.8 0.6 -0.1
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.7 0.4 -1.1 -1.9 1.0 -0.3 1.1 1.2
Hearing difficulty/problems: Yes 3.7 5.6 11.3 2.0 -3.4 -0.3 2.9 -0.5 2.5 3.0
Relative age of first facial hair 0.1 0.2 0.4 0.3 -0.4 0.1 0.6 -0.4 -0.4 0.5
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 6.1 2.5 -1.6 0.8 1.9 0.4 2.2 1.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.5 0.4 -0.9 -0.3 0.0 -0.2 0.7 1.2
Ever had hysterectomy (womb removed) 0.3 0.4 0.7 0.3 -0.4 0.7 -0.8 -0.2 0.8 0.8
Systolic blood pressure, automated reading 2.8 8.3 11.8 -3.4 3.4 3.3 -3.4 1.2 -1.7 -2.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.5 0.3 0.3 -1.2 0.3 0.2 -0.1 -0.0
Angina 0.7 0.9 1.6 0.1 0.8 1.2 0.8 1.2 -0.7 -1.3
Medication for hormone replacement therapy 0.3 0.3 0.9 -0.5 0.2 -0.9 0.3 0.8 -0.4 0.1
Vitamin and mineral supplements 1.9 2.6 5.6 -1.9 1.7 1.0 -1.2 -0.5 -1.8 -2.4
Supplements: Zinc 0.6 0.7 2.1 0.2 -0.4 -1.4 0.2 -1.4 0.6 0.3
Medication: Co-codamol 0.2 0.2 0.5 -0.2 0.4 -0.4 0.5 -0.3 -0.7 -0.3
Medication: Metformin 1.5 2.2 6.0 1.7 -1.1 -2.2 2.5 0.3 0.2 -0.1
Diabetes (father) 1.0 1.3 2.5 -1.6 1.3 0.6 -0.6 -0.5 -1.6 -1.3
Diabetes (mother) 1.3 1.7 7.3 0.2 -0.4 1.7 2.7 0.3 -1.0 -0.3
Severe depression (siblings) 0.4 0.4 1.3 -0.2 -0.0 0.4 -0.0 1.0 1.1 0.6
Pack years adult smoking proportion 0.9 1.4 5.7 1.2 -0.5 0.9 2.4 1.1 0.2 0.3
Impedance of leg (right) 0.1 0.4 1.3 -0.0 -0.6 0.4 -0.2 -0.5 1.2 0.9
Leg fat-free mass (left) 0.2 1.0 3.4 1.9 -1.0 -0.1 1.5 -0.2 0.3 0.8
Trunk fat percentage 0.4 1.8 5.2 2.3 -1.3 0.4 1.9 0.2 1.1 0.7
Hand grip strength (right) 0.3 0.9 2.5 -1.5 0.4 -1.6 0.4 -0.8 -0.3 -0.4
Townsend deprivation index at recruitment 0.3 0.4 1.1 -1.1 0.4 -0.5 -0.4 0.5 -0.4 -0.8
Current tobacco smoking 0.3 0.5 2.5 -0.3 -0.1 0.1 1.6 0.6 -0.6 -0.6
Average weekly fortified wine intake 3.5 4.1 9.2 -1.9 3.0 0.4 -2.2 0.7 -2.1 -2.5
Maternal smoking around birth 0.7 1.0 2.5 -1.1 0.8 -0.0 0.6 -0.2 -1.4 -1.6
Fed-up feelings 2.6 4.8 6.9 -2.2 2.5 -1.4 -2.6 -1.0 -2.4 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 3.5 -1.4 0.7 -1.9 -0.2 -0.5 -1.4 -1.1
Relative age voice broke 1.1 1.6 5.5 -0.7 1.1 0.2 -0.5 -0.8 -2.3 -1.8
Taking other prescription medications 0.1 0.2 0.9 0.5 -0.2 0.3 0.9 0.0 0.2 -0.4
Age when periods started (menarche) 0.4 1.0 1.7 -1.2 0.2 -1.2 1.3 -0.6 -1.3 -0.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 -0.1 0.5 -0.1 -0.6 -0.2 -0.8 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 -0.8 0.5 -0.0 -0.6 0.2 -1.0 -0.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 5.7 0.1 -1.3 -0.2 1.1 0.2 0.8 2.4
Qualifications: CSEs or equivalent 1.6 2.1 5.2 -0.8 1.7 1.4 -2.3 1.1 -1.5 -0.6
Serious illness, injury or assault to yourself 1.8 2.2 4.6 1.7 -1.7 -0.7 2.1 0.1 1.2 1.7
High blood pressure 0.7 1.9 3.7 -0.9 1.6 1.4 -1.5 0.9 -1.2 -1.9
Hayfever, allergic rhinitis or eczema 1.5 3.4 7.2 -2.0 2.4 0.6 -1.2 0.9 -2.7 -2.0
Multivitamins +/- minerals 1.1 1.4 3.5 1.3 -1.1 -0.9 0.5 1.0 1.1 1.9
Stomach or abdominal pain in last month 0.5 0.6 1.8 0.2 -1.0 -0.3 1.3 -0.7 -0.7 0.6
Supplements: Glucosamine 0.2 0.2 1.0 0.1 0.3 -0.7 0.2 -0.1 -1.0 -0.3
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.5 1.9 -1.1 -0.2 0.2 0.1 1.9 1.1
Medication: Atenolol 0.2 0.2 0.6 0.8 -0.4 0.0 0.8 0.2 -0.1 -0.6
Medication: Levothyroxine sodium 0.8 1.4 4.4 1.5 -0.6 2.1 0.4 0.4 1.0 1.0
Sitting height 0.4 2.6 5.2 1.6 -2.0 0.5 2.3 -0.3 1.8 1.6
Chronic bronchitis/emphysema (father) 0.2 0.2 0.9 -1.0 0.5 0.6 -0.3 0.1 0.1 -0.1
High blood pressure (mother) 1.7 2.4 5.6 -2.3 1.5 1.0 -2.4 0.1 -1.1 -1.1
Body mass index (BMI) 0.2 0.8 3.3 1.8 -0.4 0.4 1.4 0.5 -0.1 -0.2
Impedance of leg (left) 0.1 0.3 0.9 -0.4 -0.3 0.5 -0.1 -0.3 1.0 0.6
Leg predicted mass (left) 0.2 1.0 3.3 1.8 -1.0 -0.0 1.4 -0.2 0.2 0.8
Trunk fat mass 0.6 2.6 7.8 2.8 -1.6 0.4 2.1 0.2 1.3 1.1
Waist circumference 1.0 3.7 12.0 3.5 -1.7 1.2 2.4 1.1 1.2 1.1
Number of incorrect matches in round 1.7 2.8 5.2 2.2 -2.3 -0.6 0.9 -0.5 2.2 1.8
Past tobacco smoking 0.2 0.3 0.7 -0.4 0.7 0.6 0.2 -0.1 -0.8 -0.4
Alcohol usually taken with meals 1.4 2.2 8.1 1.1 -1.4 -2.9 0.7 -0.7 1.2 1.3
Nervous feelings 0.1 0.2 0.5 -0.3 -0.3 0.0 -0.7 -0.5 0.4 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.4 0.6 -0.5 -1.2 0.8 0.5 -0.0 0.6
Hearing difficulty/problems with background noise 0.1 0.1 0.4 0.2 -0.4 0.1 -0.5 -0.6 0.3 0.1
Hair/balding pattern: Pattern 2 3.4 4.3 7.3 -1.9 2.7 1.7 -2.7 0.6 -1.8 -2.3
Had menopause 0.4 0.5 1.8 1.0 -0.7 0.2 0.0 0.4 1.4 0.1
Had other major operations 0.4 0.5 2.0 1.4 -0.4 -0.5 0.6 0.9 0.3 0.2
Forced vital capacity (FVC) 0.6 2.2 4.3 0.7 -2.1 -1.4 0.6 -2.0 1.3 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.7 -0.9 0.7 1.0 -0.3 0.5 -1.3 -0.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.4 -0.5 -0.5 -1.0 0.7 0.4 1.6 0.9
Qualifications: None of the above 0.7 1.4 4.0 -0.5 1.2 2.0 -1.3 1.3 -0.4 -0.8
Financial difficulties in last 2 years 0.7 1.0 1.9 -1.2 0.5 -1.0 0.2 -0.9 -1.1 -1.4
Mouth/teeth dental problems 2.5 3.8 8.7 -3.0 2.6 0.3 -2.3 0.3 -1.8 -1.5
Heart attack 2.0 2.6 5.2 -1.8 1.7 -0.8 -1.2 -0.7 -2.3 -2.0
Allergy 3.3 7.6 17.0 2.7 -3.4 -1.7 1.6 -1.7 4.1 2.9
Pain all over the body in last month 1.1 1.2 4.4 1.7 -0.4 -0.2 2.1 0.8 0.2 0.5
Diabetes (self-reported) 0.3 0.5 1.1 1.1 -0.7 -0.9 1.0 0.3 0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.2 -1.1 1.5 0.6 -0.4 1.2 -1.5 -1.0
Medication: Ramipril 0.7 0.9 2.9 -0.5 1.0 -0.5 -0.5 -0.1 -1.3 -1.7
Medication: Simvastatin 0.6 0.9 4.0 0.7 0.6 2.0 -0.1 1.2 0.1 -0.1
Fluid intelligence score 0.1 0.2 1.1 0.1 0.1 0.6 -1.1 0.3 -0.0 -0.1
Illnesses of siblings 0.3 0.4 1.5 -0.5 0.3 -0.9 -1.2 -0.1 0.5 0.1
Neuroticism score 0.4 0.9 4.8 -0.1 0.5 -0.5 -2.2 -0.2 -0.3 -0.8
Weight 0.5 2.4 7.6 2.8 -1.6 -0.1 2.1 -0.0 1.1 1.0
Impedance of arm (right) 0.5 2.5 6.1 1.0 -2.1 0.2 1.0 -0.9 2.5 2.1
Arm fat percentage (right) 0.6 2.2 6.8 2.6 -1.5 0.8 2.0 0.1 1.1 1.0
Trunk fat-free mass 0.3 1.5 4.5 2.1 -1.4 -0.1 1.4 -0.3 0.7 1.3
Hip circumference 0.4 1.5 5.2 2.3 -0.8 0.5 2.0 0.4 0.5 0.4
Time employed in main current job 0.3 0.4 1.1 0.5 -0.6 -0.7 0.2 0.2 1.0 0.7
Alcohol intake versus 10 years previously 0.6 0.9 4.2 0.2 -0.8 -0.7 2.0 0.3 0.6 0.6
Father’s age at death 1.2 1.6 4.7 0.9 -1.3 -2.2 0.5 -1.6 1.0 0.6
Worrier / anxious feelings 1.4 2.6 6.1 2.5 -2.0 -0.9 0.5 -0.2 2.2 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.7 -0.5 0.7 0.6 -0.2 0.2 -1.3 -1.2
Falls in the last year 0.7 1.0 2.1 0.6 -1.4 -0.7 1.2 -0.7 0.9 1.1
Hair/balding pattern: Pattern 3 0.8 1.1 4.4 0.5 -1.1 -2.1 0.5 -0.8 0.4 1.0
Number of live births 0.4 0.6 2.0 -0.4 0.4 -1.4 -0.3 -0.7 -1.1 -0.5
Forced expiratory volume in 1-second (FEV1) 1.8 6.2 10.5 1.7 -3.2 -2.5 1.4 -2.9 2.3 2.9
Pulse rate 3.5 5.9 17.9 2.5 -2.7 -2.3 4.2 -0.5 1.6 1.4
Happiness 2.1 2.5 5.7 1.1 -1.9 -0.7 2.4 -0.6 1.8 1.8
Noisy workplace 0.3 0.4 1.0 -0.3 0.5 0.9 1.0 0.5 -0.3 -0.4
Qualifications: A levels/AS levels or equivalent 1.5 3.4 8.2 1.3 -2.3 0.7 0.8 -0.6 2.6 2.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.5 0.5 -0.0 -0.2 0.9 1.2 0.6 0.6
Mouth/teeth dental problems: Dentures 0.3 0.5 1.4 1.1 -0.8 -1.2 -0.0 -0.6 0.5 -0.1
Asthma 3.1 6.1 9.2 -2.1 3.0 2.6 -1.5 2.6 -3.0 -2.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.7 0.0 0.1 0.4 0.1 0.1 -0.9 0.2
Medication: Cholesterol lowering 0.1 0.2 0.7 0.5 0.0 0.3 -0.0 0.6 0.9 0.1
Depression (self-reported) 0.7 0.8 2.0 0.6 -0.9 -1.4 1.3 -0.6 0.7 0.5
Medication: Lansoprazole 0.4 0.5 1.2 0.6 0.7 0.4 0.4 0.4 -1.1 -0.8
Prospective memory result 1.0 1.3 2.1 -0.2 1.5 1.4 -0.4 1.1 -1.2 -1.3
Lung cancer (father) 0.6 0.7 1.6 -0.5 1.2 0.6 -0.4 0.2 -1.0 -1.3
Illnesses of mother 0.3 0.4 1.7 0.2 0.2 -1.3 0.2 -0.0 -0.8 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 9.3 1.5 -3.1 -1.8 1.3 -2.8 2.5 3.0
Pulse wave Arterial Stiffness index 0.1 0.1 0.3 -0.6 0.4 -0.0 -0.3 0.3 0.2 -0.0
Impedance of arm (left) 0.4 1.8 5.7 0.5 -1.7 0.3 0.4 -0.9 2.4 1.6
Arm fat mass (right) 0.5 2.1 7.0 2.6 -1.3 0.7 2.0 0.2 0.8 0.8
Trunk predicted mass 0.3 1.5 4.5 2.1 -1.4 -0.2 1.4 -0.2 0.7 1.3
Standing height 0.4 4.2 6.9 2.3 -2.6 -0.7 1.5 -0.9 2.5 2.6
Length of working week for main job 0.6 0.7 2.0 1.4 -0.4 0.6 0.2 1.2 -0.4 0.8
Exposure to tobacco smoke at home 0.7 0.8 2.6 0.4 -0.4 0.8 1.6 1.0 -0.9 -0.7
Breastfed as a baby 1.2 1.5 5.1 1.1 -1.2 0.9 0.1 0.4 2.3 1.3
Tense / ‘highly strung’ 0.3 0.5 1.3 1.1 -0.9 -0.5 0.6 0.1 0.6 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.5 0.0 -0.8 -1.6 0.2 -1.4 0.6 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.5 -0.6 0.8 1.0 0.1 1.2 -0.2 -0.4
Birth weight of first child 0.8 1.4 3.2 1.8 -1.0 -1.4 1.0 -1.1 0.9 0.6
Peak expiratory flow (PEF) 0.4 1.0 2.3 0.4 -1.2 -1.5 0.3 -1.5 0.6 0.8
Pulse wave reflection index 0.2 0.3 1.1 -0.5 0.5 0.5 -1.1 -0.2 -0.1 -0.2
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.0 -1.6 1.7 -0.2 0.1 0.3 -1.6 -1.7
Loud music exposure frequency 0.6 0.7 2.0 0.9 -0.7 0.8 1.4 -0.0 0.3 0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.8 -1.3 0.7 1.1 -0.6 0.3 -0.5 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.1 1.1 -0.7 0.6 0.9 0.1 0.4 0.5
Blood clot in the leg (DVT) 1.5 1.9 5.6 -1.0 1.2 -0.0 -1.6 -0.5 -2.4 -1.5
Medication: Paracetamol 1.0 1.6 3.3 1.8 -1.5 -0.2 1.8 -0.2 0.9 1.4
Headache pain in last month 1.4 2.5 7.4 2.7 -1.5 -1.6 0.4 0.4 1.5 1.5
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.4 -0.5 0.2 0.6 -0.5 -0.2 -0.1 0.2
Glaucoma (self-reported) 0.3 0.3 0.8 -0.7 0.7 -0.4 -0.5 0.2 -0.9 -0.3
Gout (self-reported) 0.8 1.0 1.8 -1.3 0.9 -1.3 -1.1 0.3 -1.3 -0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.3 1.4 -0.4 1.5 0.4 0.4 0.6 0.8
Medication: Amlodipine 1.8 2.5 4.4 -1.4 1.9 2.1 -1.4 1.6 -1.1 -1.3
Medication: Ventolin 100micrograms inhaler 3.1 4.0 7.1 -2.7 2.7 2.2 -1.4 1.0 -2.0 -1.4
Birth weight 2.1 4.5 8.7 2.7 -2.6 0.7 1.0 -0.4 2.6 2.9
Chronic bronchitis/emphysema (mother) 3.7 4.4 9.6 2.0 -3.1 -0.5 1.5 -1.2 2.9 2.2
High blood pressure (siblings) 0.1 0.2 1.1 -0.3 0.2 1.1 -0.3 0.3 -0.0 -0.1
Forced vital capacity (FVC), Best measure 0.4 1.3 2.8 0.4 -1.5 -0.5 0.3 -1.4 1.3 1.7
Body fat percentage 0.4 1.6 5.4 2.3 -1.1 0.7 1.6 0.3 0.9 0.5
Leg fat percentage (right) 0.4 1.4 6.3 2.5 -0.9 0.3 1.5 0.2 0.5 0.2
Arm fat-free mass (right) 0.1 0.3 1.3 1.1 -0.1 0.3 0.6 0.1 -0.3 -0.0
Exposure to tobacco smoke outside home 1.4 1.9 8.7 1.1 -1.1 0.4 3.0 1.2 0.8 0.4
Comparative body size at age 10 0.9 2.4 5.5 2.2 -2.0 0.6 0.3 -0.7 2.3 1.3
Number of full brothers 1.2 1.5 3.0 1.6 -1.3 0.1 1.7 1.2 -0.1 1.4
Worry too long after embarrassment 0.9 1.4 6.2 -0.4 0.9 1.0 -2.5 1.2 -0.5 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.9 -0.2 0.6 0.3 -0.7 0.2 -0.7 -0.9
Wheeze or whistling in the chest in last year 0.9 1.7 3.5 -1.3 1.4 1.1 -0.8 1.9 -1.2 -1.1
Number of children fathered 0.2 0.3 0.8 -0.6 0.7 0.0 -0.0 0.1 -0.9 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 2.6 1.6 -1.2 -1.0 -0.2 0.2 0.9 1.3
Age at first live birth 0.9 1.7 3.1 1.2 -1.8 -0.9 0.9 -1.6 1.3 1.1
Pulse wave peak to peak time 0.1 0.2 0.3 0.5 -0.6 -0.3 0.4 -0.6 -0.1 0.1
Health satisfaction 0.5 0.7 1.6 -0.7 0.6 -0.2 1.2 -0.1 -1.3 -0.9
Shortness of breath walking on level ground 3.6 4.3 7.5 -2.2 2.7 1.4 -1.1 0.9 -2.6 -2.7
Qualifications: College or University degree 0.3 0.9 2.6 0.7 -1.0 0.3 0.3 -0.6 1.2 1.6
Eye problems/disorders: None of the above 0.3 0.3 1.1 -0.3 0.3 1.0 0.1 0.3 -0.6 -0.7
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.5 1.0 -1.2 -1.1 1.6 -0.3 -0.1 0.4
Emphysema/chronic bronchitis 0.7 0.7 2.8 -1.7 0.8 -1.1 -0.7 0.1 0.0 -0.3
Medication for pain relief, constipation, heartburn 1.2 2.1 6.9 -2.6 1.4 -0.8 -1.5 -0.8 -0.8 -1.3
Neck or shoulder pain in last month 0.6 0.8 2.8 0.7 -1.1 -0.3 1.7 0.3 -0.7 0.8
Medication: Blood pressure 0.3 0.5 1.4 -0.4 0.3 -0.8 -0.3 0.1 -1.0 -1.2
Angina (self-reported) 0.5 0.7 1.5 0.3 0.5 0.7 1.0 1.1 -0.6 -1.2
Migraine (self-reported) 0.4 0.5 1.1 1.0 -0.4 -0.8 0.0 0.9 0.8 0.4
Medication: Ibuprofen 0.2 0.2 0.5 0.1 -0.2 0.3 0.6 -0.4 -0.7 0.4
Medication: Allopurinol 0.4 0.5 2.2 -0.2 0.3 -1.5 -0.7 0.2 -0.9 0.3
Medication: Omeprazole 0.3 0.4 1.0 1.0 -0.4 -0.1 0.8 -0.7 -0.1 -0.4
Medication: Seretide 50 evohaler 1.1 1.2 3.6 -0.4 0.8 1.9 -0.5 1.4 -1.0 -1.0
Mean time to correctly identify matches 0.4 0.7 1.4 0.7 -0.9 -0.9 0.4 -1.2 1.2 0.3
Heart disease (mother) 0.4 0.4 1.1 0.8 -0.5 -0.4 1.1 -0.1 0.7 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.3 -1.0 1.4 0.2 -0.3 1.1 -1.8 -0.8
Whole body fat mass 0.4 1.8 6.7 2.6 -1.1 1.0 1.7 0.3 0.8 0.6
Leg fat mass (right) 0.4 1.4 6.0 2.4 -0.8 0.6 1.7 0.1 0.3 0.3
Arm predicted mass (right) 0.1 0.3 1.5 1.2 -0.2 0.0 0.7 0.1 -0.3 -0.0
Pulse rate, automated reading 2.4 7.6 18.2 4.0 -3.3 -1.8 4.3 0.0 1.4 1.9
Alcohol intake frequency. 0.3 0.7 1.2 -0.7 0.5 -1.1 0.9 -0.3 -1.0 -1.1
Comparative height size at age 10 1.0 5.5 11.5 3.0 -2.6 0.7 1.7 0.4 3.4 2.8
Number of full sisters 0.6 0.7 2.6 1.2 0.1 0.7 0.4 1.6 0.0 0.5
Suffer from ‘nerves’ 0.5 0.8 3.9 -0.6 0.6 -0.5 -2.0 0.4 -0.0 -0.5
Overall health rating 0.4 0.9 3.7 0.8 -0.5 0.7 1.9 1.0 0.5 0.1
Chest pain or discomfort 0.4 0.5 1.1 0.6 -0.0 1.0 1.1 0.8 -0.2 -0.7
Had major operations 0.8 0.9 2.2 1.2 -0.9 -0.2 -1.0 0.1 1.0 1.5
Age at last live birth 1.2 1.8 4.1 0.3 -1.3 -2.0 0.8 -1.9 1.2 1.1
Family relationship satisfaction 0.8 0.9 2.6 -0.2 -0.8 0.5 0.5 -0.3 1.6 1.6
Leg pain on walking 0.9 1.1 2.7 -0.1 0.5 1.6 1.3 0.9 -1.0 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.0 -0.1 -0.6 -1.0 0.6 0.1 0.6 1.0
Commuting to job workplace: Car/motor vehicle 0.6 0.6 1.7 0.2 0.8 0.7 0.4 0.5 -1.1 -1.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.8 0.0 -0.3 0.4 -1.3 -0.9 0.1 0.5
Medication: Aspirin 0.4 0.5 1.3 1.1 -0.1 0.8 0.4 1.0 0.5 -0.1
Supplements: Vitamin C 0.4 0.4 0.9 0.5 -0.6 -0.9 -0.4 -0.6 0.5 0.9
Knee pain experienced in last month 2.6 4.0 7.2 2.2 -2.7 -0.2 2.1 0.5 1.9 2.7
Hypertension (Self-reported) 1.1 3.0 4.8 -1.3 2.0 1.9 -1.7 1.4 -1.5 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.6 0.5 -0.1 -0.6 -1.3 -0.5 -0.3 0.0
Illnesses of father: Heart disease 0.3 0.5 1.1 0.4 -0.4 -1.0 0.9 -0.3 -0.9 -0.4
Illnesses of siblings: Diabetes 1.0 1.3 4.5 1.3 -1.1 -0.8 2.1 -0.0 -0.0 1.0
Smoking status: Previous 0.2 0.3 1.4 0.1 -0.3 -0.1 -1.2 0.2 0.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.3 0.0 -0.0 -0.0 0.5 0.3 -0.4 0.4
Whole body fat-free mass 0.2 1.1 3.9 2.0 -1.0 -0.1 1.4 -0.1 0.4 0.9
Leg fat-free mass (right) 0.1 0.6 2.1 1.4 -0.6 -0.0 1.3 -0.0 -0.0 0.5
Arm fat percentage (left) 0.4 1.5 5.2 2.3 -1.2 0.8 1.6 0.1 0.9 0.6
Average weekly red wine intake 0.3 0.5 1.7 0.1 -0.1 -1.3 0.6 -0.6 -0.8 -0.2
Handedness (chirality/laterality): Left-handed 2.1 2.6 7.4 1.1 -1.6 -2.7 1.9 0.5 0.7 1.6
Mood swings 0.4 0.8 2.2 1.4 -0.7 -1.5 0.2 -0.6 0.3 0.3
Loneliness, isolation 0.7 1.0 3.2 -1.4 1.0 -0.1 -1.8 -0.2 -0.7 -0.6
Long-standing illness, disability or infirmity 0.6 0.9 2.3 -0.8 1.5 0.3 0.3 0.2 -1.0 -1.5
Ever had bowel cancer screening 1.4 1.7 4.5 1.3 -1.1 1.4 0.5 0.8 2.1 1.3
Diabetes diagnosed by doctor 0.9 1.5 4.2 1.6 -1.2 -1.2 2.1 0.2 0.6 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 4.9 -0.3 0.3 -2.2 -0.1 -0.7 -1.2 -0.5
Friendships satisfaction 1.6 2.0 3.5 0.9 -1.7 -0.4 1.9 -0.5 1.8 1.7
Qualifications: nursing, teaching 0.3 0.4 1.8 -0.0 -0.5 -1.3 0.4 -1.0 -0.0 -0.1
Commuting to job workplace: Walk 0.4 0.4 1.8 -0.4 -0.2 -0.4 0.9 -1.4 0.3 -0.1
Eye problems/disorders: Cataract 0.8 0.9 2.7 0.1 -1.2 -0.6 0.8 -0.6 1.6 1.0
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.5 1.0 -1.9 0.8 1.5 -0.3 1.3 1.0
Medication for cholesterol 1.6 2.5 4.3 1.0 -2.1 -1.4 1.3 -1.8 1.8 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.5 0.5 -0.4 0.6 -0.7 -0.7 0.5 0.3
Back pain experienced in last month 1.1 1.6 9.7 0.4 0.0 3.1 0.8 0.6 0.0 0.5
Mineral and other dietary supplements 0.4 0.5 1.2 -1.1 0.4 0.5 -0.7 0.1 -0.6 -1.0
Breast cancer (self-reported) 1.6 1.9 3.6 1.7 -1.9 0.8 1.6 0.1 1.5 1.3
Asthma (self-reported) 3.5 6.9 10.2 -2.2 3.2 2.7 -1.9 2.6 -3.2 -2.3
Osteoporosis (self-reported) 1.6 2.0 3.7 1.1 -1.9 -1.3 1.1 -0.8 1.9 1.4
Osteoarthritis (self-reported) 1.0 1.3 3.8 0.9 -1.3 -2.0 0.9 -1.2 0.6 -0.5
Medication: Aspirin 0.2 0.2 0.6 0.7 0.0 0.5 0.1 0.7 0.4 -0.2
Medication: Gliclazide 1.1 1.3 2.7 -0.9 0.9 -1.4 0.6 -0.1 -1.6 -1.6
Illnesses of father: None of the above (group 1) 0.5 0.6 2.0 0.3 -0.5 0.0 0.4 0.1 1.4 1.3
Smoking status: Current 0.4 0.6 2.9 -0.4 0.0 0.4 1.7 0.6 -0.7 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.5 -0.2 -1.0 -0.3 -0.2 -1.9 1.1 1.4
Whole body water mass 0.2 1.1 4.0 2.0 -1.0 -0.1 1.3 -0.0 0.4 0.9
Leg predicted mass (right) 0.1 0.7 2.4 1.5 -0.7 -0.0 1.3 -0.0 0.1 0.6
Arm fat mass (left) 0.4 1.8 6.1 2.5 -1.2 0.6 1.9 0.2 0.6 0.6
Number of self-reported non-cancer illnesses 0.3 0.5 1.5 0.8 0.3 1.2 0.4 0.9 -0.2 -0.5
Average weekly champagne plus white wine intake 0.3 0.4 1.1 0.9 0.6 -1.0 -0.2 0.4 -0.1 -0.1
Miserableness 1.5 2.6 9.2 -1.1 1.6 -0.2 -3.0 -0.6 -1.4 -1.7
Guilty feelings 0.4 0.6 1.3 0.4 -1.1 -0.7 -0.6 -0.7 1.2 0.4
Wears glasses or contact lenses 1.1 1.2 3.2 1.4 -1.1 -0.8 0.3 0.5 1.8 1.2
Ever taken oral contraceptive pill 0.3 0.4 1.4 -0.1 -0.5 -0.8 1.2 0.1 0.1 0.5
Hearing aid user 0.4 0.4 1.3 0.1 -0.3 -0.9 -0.5 0.6 1.1 0.5
Mother’s age at death 1.1 1.4 6.6 -0.3 1.2 0.4 -2.6 -0.0 -0.5 -1.1
Financial situation satisfaction 0.3 0.3 0.7 -0.5 -0.8 -0.8 0.4 -0.5 0.3 0.6
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.9 -0.8 1.3 0.7 -0.5 0.4 -1.3 -2.0
Commuting to job workplace: Public transport 0.1 0.1 0.4 -0.1 -0.2 0.2 -0.6 -0.1 0.2 0.6
Eye problems/disorders: Glaucoma 0.4 0.5 1.1 -0.4 0.8 0.5 -1.1 0.6 -0.8 -0.4
Medication: Blood pressure 1.6 3.0 4.5 -1.4 2.1 1.6 -2.0 1.0 -1.9 -2.0
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.8 1.3 -1.4 0.1 1.1 -1.3 0.2 0.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 3.9 1.3 -0.9 0.6 0.2 -0.6 2.0 1.7
High cholesterol (Self-reported) 0.6 1.1 4.2 0.5 1.0 2.1 -0.9 1.2 0.1 -0.6
Medication: Bendroflumethiazide 0.3 0.5 1.4 -0.8 0.7 0.5 -1.2 0.8 -0.0 -0.1
Medication: Paracetamol 0.8 1.3 3.6 1.4 -1.4 0.2 1.9 -0.7 0.5 0.8
Medication: Lisinopril 0.5 0.6 1.7 -1.0 0.7 0.0 -1.3 0.5 -1.0 -0.1
Medication: Atorvastatin 0.4 0.4 1.3 0.8 -1.0 0.1 0.3 -0.2 1.1 0.2
Illnesses of father: High blood pressure 0.2 0.2 0.7 -0.0 -0.4 0.8 -0.0 0.3 -0.4 0.4
Alcohol drinker status: Never 1.1 1.3 3.7 -0.8 0.4 -1.9 -0.4 -1.2 -1.2 -1.3
Ever smoked 0.3 0.5 1.2 0.5 -0.8 -1.0 0.4 0.5 1.1 0.5
Basal metabolic rate 0.3 1.5 5.0 2.2 -1.2 0.0 1.6 -0.1 0.6 1.0
Leg fat percentage (left) 0.4 1.4 5.8 2.4 -0.8 0.3 1.7 0.4 0.4 0.1
Arm fat-free mass (left) 0.2 1.0 3.5 1.9 -0.8 -0.3 1.5 0.3 0.0 0.6
Number of operations (self-reported) 1.8 2.6 6.4 2.5 -2.0 -1.2 1.7 0.0 1.4 1.4
Average weekly beer plus cider intake 0.3 0.5 1.3 -0.4 0.3 0.8 1.2 0.2 -0.9 -0.5
Irritability 0.7 1.2 2.7 1.6 -1.2 -1.5 1.1 0.0 0.4 0.6
Risk taking 0.8 1.1 4.8 -1.2 0.9 -0.3 -0.4 0.4 -2.2 -0.7
Ever had prostate specific antigen (PSA) test 1.6 1.8 4.5 1.2 -1.8 -0.5 0.2 0.5 1.8 2.1
Fractured/broken bones in last 5 years 1.2 1.5 4.2 -0.2 -1.4 -1.1 2.1 -1.7 0.4 -0.1
Age started oral contraceptive pill 0.2 0.3 0.5 0.7 -0.5 0.4 0.6 -0.5 0.7 0.1
Diastolic blood pressure, automated reading 0.9 2.7 4.4 -2.1 2.1 1.3 -1.6 0.6 -1.7 -1.7
Ever depressed for a whole week 0.8 1.0 2.8 0.3 -0.9 -1.7 0.7 -0.3 1.4 0.9
Unable to work because of sickness or disability 0.2 0.3 0.7 0.7 -0.9 -0.3 0.4 -0.2 0.5 0.7
Commuting to job workplace: Cycle 1.3 1.6 4.4 0.6 -1.0 0.9 -0.5 0.2 2.0 2.1
Myopia 0.4 0.6 2.9 -0.4 0.6 1.7 -0.9 0.5 -0.3 -0.2
Vascular/heart problems diagnosed by doctor 1.2 3.2 5.7 1.5 -2.2 -1.5 1.8 -1.1 1.6 2.4
Cholesterol lowering medication 0.6 0.9 4.0 0.5 0.8 2.0 -0.2 1.1 -0.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.2 1.0 -1.1 -0.4 0.8 -0.9 0.4 0.1
Pain experienced in last month 3.4 5.7 11.6 -3.4 2.5 -0.8 -2.6 -1.1 -1.8 -3.1
Supplements: Calcium 1.2 1.3 3.1 1.1 -1.0 -1.6 1.8 -0.8 0.3 0.6
Basal cell carcinoma (self-reported) 1.3 1.6 3.6 0.7 -1.3 -1.7 0.1 0.0 1.9 1.5
Heart attack/myocardial infarction (self-reported) 1.7 2.1 4.9 -1.5 1.6 -0.6 -1.1 -0.3 -2.2 -1.9
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 7.6 -1.3 1.5 -0.1 -1.8 -0.8 -2.8 -1.9
Heart disease (siblings) 0.8 1.0 2.0 0.7 0.4 1.4 1.3 1.0 -1.0 -0.7
Alcohol drinker status: Previous 0.1 0.1 0.4 0.3 -0.3 -0.6 0.6 0.1 0.4 0.0
Pack years of smoking 1.2 1.7 5.7 1.7 -0.6 1.0 2.4 1.2 0.4 0.4
Impedance of whole body 0.1 0.7 2.3 -0.2 -0.9 0.4 -0.0 -0.6 1.5 1.1
Leg fat mass (left) 0.4 1.5 5.6 2.4 -0.8 0.7 1.8 0.3 0.3 0.2
Arm predicted mass (left) 0.2 1.0 3.5 1.9 -0.9 -0.1 1.5 0.2 0.2 0.7