Hub : Genes

USP54

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.1413 0.0570 0.00001 0.064 NA 0.038 NA 0.055 2.6e-05 NA 0.0011 NA 9.5e-05
2 TCGA Breast Invasive Carcinoma 0.0108 0.0092 0.00610 0.013 0.009 0.008 NA 0.011 6.8e-04 0.0056 0.0064 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 0.9 0.9 -0.9
Bipolar Disorder or Schizophrenia 0.3 0.8 1.0 0.7 -1.0
Depressed Affect (Nagel 2018) 2.7 5.8 8.0 -2.8 1.9
Depression (Nagel 2018) 1.1 1.6 2.0 -1.4 1.1
Intelligence (Savage-Jansen 2018) 0.7 2.1 2.1 1.5 -1.4
Neuroticism (Nagel 2018) 0.9 2.0 2.5 -1.6 1.2
Schizophrenia (2018) 0.1 0.2 0.3 0.2 -0.5
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 -0.8 0.2
Worry (Nagel 2018) 0.2 0.4 0.5 -0.6 0.7
Alzheimer’s Disease (in mother) 0.8 0.9 1.6 -0.4 1.3
Alzheimer’s Disease (in father) 0.0 0.0 0.0 -0.2 -0.2
Alzheimer’s Disease (including proxy) 0.4 0.5 0.9 -0.4 1.0
Crohns Disease (2017) 0.0 0.1 0.1 -0.3 -0.3
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.2 0.2
Ulcerative Colitis (UC) 0.1 0.2 0.5 -0.1 0.7
Major Depression (MDD) 0.0 0.0 0.1 0.3 -0.1
Reaction Time 0.1 0.1 0.1 0.4 -0.3
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.2 0.4 -0.4
Breast Cancer 4.4 10.5 11.2 -3.1 3.4
Ovarian Cancer 0.1 0.1 0.2 -0.5 0.2
Prostate Cancer 0.3 0.4 0.5 0.6 -0.7
Age at First Birth 0.0 0.0 0.0 0.0 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.1 -0.3 -0.1
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 0.4 -0.6
Coronary Artery Disease (CAD) 0.9 1.1 1.2 -1.0 1.1
Crohns Disease (2012) 0.3 0.4 0.7 0.4 -0.9
Mean Putamen Volume 0.3 0.3 0.4 -0.5 0.6
Fasting Glucose 0.2 0.3 0.5 -0.7 -0.3
HbA1C 1.6 1.8 2.2 1.2 -1.5
HDL Cholesterol 1.5 2.5 3.5 1.9 -1.2
LDL Cholesterol 0.8 1.2 2.2 1.5 -0.5
Lupus 1.5 2.2 2.8 1.7 -1.3
Neuroticism (2016) 1.6 2.3 3.2 -1.2 1.8
Primary Biliary Cirrhosis 3.7 5.3 5.6 2.2 -2.4
Rheumatoid Arthritis 0.1 0.2 0.3 0.3 0.5
Schizophrenia (2014) 0.4 1.0 1.5 0.7 -1.2
Triglycerides 1.8 3.0 4.6 -2.1 1.1
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.3 -0.5 0.2
Ulcerative Colitis 0.1 0.1 0.1 0.2 0.4
Blood Eosinophil Count 0.7 5.6 6.5 -2.5 2.2
Blood Platelet Count 0.0 0.1 0.2 0.1 0.5
Blood Red Count 0.0 0.3 0.4 0.6 -0.4
Blood White Count 0.0 0.1 0.2 -0.4 0.0
Heel T-Score 0.6 4.6 6.5 -1.6 2.5
BMI 0.1 0.4 0.7 -0.4 -0.8
Height 0.5 9.2 11.4 2.6 -3.4
Waist Hip Ratio (WHR) 2.2 9.9 11.4 3.4 -2.9
Systolic Blood Pressure 4.5 22.3 23.7 -4.9 4.6
Smoking Status 0.1 0.3 0.4 -0.4 0.6
Allergy or Eczema 4.1 10.7 12.8 -3.6 2.9
Cardiovascular Disease 0.5 1.7 2.4 -1.5 1.0
Hypothyroidism (self reported) 0.1 0.3 0.4 -0.6 0.5
Respiratory disease 5.2 11.5 14.3 -3.8 3.0
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 -0.1 -0.3
Lung FEV1/FVC ratio 5.1 25.8 30.6 5.5 -4.6
Lung FVC 0.7 3.8 6.6 2.6 -1.0
Neuroticism 0.7 1.7 1.7 -1.3 1.3
Chronotype (morning person) 0.9 2.1 2.2 -1.4 1.5
Hair Pigment 0.0 0.1 0.2 -0.5 0.1
Tanning 0.1 1.1 1.7 -1.3 0.8
Hand grip strength (left) 0.6 1.7 2.0 -1.4 1.2
Number of treatments/medications taken 0.1 0.3 0.4 0.3 -0.6
Average weekly spirits intake 0.4 0.5 0.7 -0.8 0.5
Sensitivity / hurt feelings 0.1 0.1 0.2 0.4 -0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.7 0.8 -0.2
Hearing difficulty/problems: Yes 5.7 8.7 10.8 3.3 -2.6
Relative age of first facial hair 0.1 0.2 0.4 0.3 -0.6
Other serious medical condition/disability diagnosed by doctor 4.1 5.3 6.8 2.0 -2.6
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.1 1.1 -0.8
Ever had hysterectomy (womb removed) 0.4 0.5 0.7 0.8 -0.5
Systolic blood pressure, automated reading 2.6 7.4 9.4 -3.1 2.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.2 -0.5
Angina 0.1 0.1 0.2 -0.5 -0.2
Medication for hormone replacement therapy 0.0 0.0 0.0 0.1 -0.1
Vitamin and mineral supplements 2.8 3.9 4.3 -2.1 1.8
Supplements: Zinc 0.0 0.0 0.0 0.1 -0.1
Medication: Co-codamol 0.2 0.2 0.3 -0.6 -0.3
Medication: Metformin 2.1 3.0 4.4 1.3 -2.1
Diabetes (father) 2.0 2.5 2.6 -1.6 1.5
Diabetes (mother) 0.0 0.0 0.0 0.2 -0.0
Severe depression (siblings) 0.1 0.1 0.1 0.3 0.4
Pack years adult smoking proportion 0.4 0.6 1.1 0.3 -1.0
Impedance of leg (right) 0.1 0.3 0.5 0.7 0.3
Leg fat-free mass (left) 0.6 3.1 5.2 1.0 -2.3
Trunk fat percentage 1.2 4.6 6.2 1.8 -2.5
Hand grip strength (right) 0.3 0.9 1.1 -1.1 0.8
Townsend deprivation index at recruitment 0.3 0.4 0.6 -0.8 0.5
Current tobacco smoking 0.1 0.2 0.3 -0.5 0.4
Average weekly fortified wine intake 5.0 5.9 7.8 -2.8 2.0
Maternal smoking around birth 1.2 1.7 2.1 -1.5 1.1
Fed-up feelings 3.6 6.6 7.9 -2.8 2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.4 -1.2 1.1
Relative age voice broke 0.6 0.9 1.5 -1.2 0.5
Taking other prescription medications 0.2 0.3 0.7 0.2 -0.8
Age when periods started (menarche) 0.6 1.5 1.9 -1.1 1.4
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.1 -0.3 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.3 0.6
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.3 1.1 -0.3
Qualifications: CSEs or equivalent 0.9 1.2 1.5 -1.2 0.9
Serious illness, injury or assault to yourself 3.5 4.3 5.3 1.8 -2.3
High blood pressure 0.1 0.4 0.6 -0.8 0.4
Hayfever, allergic rhinitis or eczema 3.2 7.0 8.0 -2.8 2.4
Multivitamins +/- minerals 1.2 1.5 1.7 1.3 -1.2
Stomach or abdominal pain in last month 0.4 0.5 0.5 0.7 -0.6
Supplements: Glucosamine 0.2 0.2 0.3 -0.6 0.3
Diverticular disease/diverticulitis (self-reported) 2.5 3.0 3.0 1.7 -1.7
Medication: Atenolol 0.1 0.1 0.1 0.4 -0.4
Medication: Levothyroxine sodium 0.7 1.2 1.6 0.9 -1.3
Sitting height 0.5 3.7 3.9 1.8 -2.0
Chronic bronchitis/emphysema (father) 0.2 0.2 0.3 -0.5 0.3
High blood pressure (mother) 2.1 2.9 4.2 -1.3 2.0
Body mass index (BMI) 0.5 2.0 3.5 0.7 -1.9
Impedance of leg (left) 0.1 0.3 0.3 0.5 0.6
Leg predicted mass (left) 0.6 3.0 5.1 0.9 -2.3
Trunk fat mass 1.6 6.8 9.4 2.1 -3.1
Waist circumference 2.1 7.8 10.7 2.2 -3.3
Number of incorrect matches in round 2.9 4.9 5.7 2.4 -2.0
Past tobacco smoking 0.1 0.2 0.3 -0.5 0.2
Alcohol usually taken with meals 1.2 2.0 2.3 1.5 -1.3
Nervous feelings 0.4 0.8 1.6 -0.2 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.3 -0.0 0.5
Hearing difficulty/problems with background noise 0.1 0.2 0.2 0.4 -0.4
Hair/balding pattern: Pattern 2 4.3 5.5 7.0 -2.6 2.0
Had menopause 0.4 0.5 0.6 0.6 -0.7
Had other major operations 0.3 0.4 0.6 0.4 -0.7
Forced vital capacity (FVC) 0.7 2.6 4.0 2.0 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.8 -0.5 0.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 0.4 0.3
Qualifications: None of the above 0.3 0.5 0.7 -0.8 0.6
Financial difficulties in last 2 years 1.1 1.5 2.0 -1.0 1.4
Mouth/teeth dental problems 4.2 6.4 6.9 -2.6 2.4
Heart attack 2.0 2.6 3.6 -1.9 1.2
Allergy 5.3 12.2 15.1 3.9 -3.1
Pain all over the body in last month 0.7 0.7 1.0 0.7 -1.0
Diabetes (self-reported) 0.9 1.3 2.2 0.7 -1.5
Hayfever/allergic rhinitis (self-reported) 2.3 3.0 3.1 -1.7 1.8
Medication: Ramipril 0.5 0.7 1.0 -1.0 0.6
Medication: Simvastatin 0.0 0.0 0.1 -0.1 -0.2
Fluid intelligence score 0.0 0.0 0.0 0.0 0.1
Illnesses of siblings 0.0 0.0 0.1 -0.1 0.3
Neuroticism score 0.2 0.5 0.5 -0.7 0.7
Weight 1.4 6.7 9.9 1.9 -3.1
Impedance of arm (right) 0.6 2.6 4.4 2.1 -0.9
Arm fat percentage (right) 1.4 5.7 7.4 2.0 -2.7
Trunk fat-free mass 0.7 4.1 6.3 1.4 -2.5
Hip circumference 0.8 3.4 5.5 1.2 -2.3
Time employed in main current job 0.7 0.9 0.9 0.9 -1.0
Alcohol intake versus 10 years previously 0.2 0.4 0.4 0.6 -0.6
Father’s age at death 1.5 2.0 2.0 1.4 -1.4
Worrier / anxious feelings 1.7 3.1 3.5 1.9 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 1.8 -1.3 1.0
Falls in the last year 1.3 1.7 2.1 1.4 -1.2
Hair/balding pattern: Pattern 3 0.7 1.1 1.3 1.2 -0.9
Number of live births 0.4 0.5 0.6 -0.6 0.8
Forced expiratory volume in 1-second (FEV1) 2.2 7.4 10.8 3.3 -2.0
Pulse rate 3.1 5.3 6.0 2.4 -2.1
Happiness 1.7 2.1 2.6 1.6 -1.3
Noisy workplace 0.1 0.2 0.3 -0.6 0.0
Qualifications: A levels/AS levels or equivalent 1.1 2.5 4.2 2.0 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.3 0.3 -0.5
Mouth/teeth dental problems: Dentures 0.2 0.4 0.4 0.6 -0.6
Asthma 3.5 6.9 9.4 -3.1 2.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 -0.1 -0.7
Medication: Cholesterol lowering 0.2 0.3 0.5 0.4 -0.7
Depression (self-reported) 0.1 0.1 0.2 0.4 0.1
Medication: Lansoprazole 0.1 0.2 0.3 -0.5 -0.2
Prospective memory result 0.8 1.0 1.7 -1.3 0.4
Lung cancer (father) 0.5 0.5 0.9 -0.9 0.5
Illnesses of mother 0.1 0.2 0.2 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.6 9.4 3.1 -1.9
Pulse wave Arterial Stiffness index 0.0 0.1 0.1 -0.3 0.1
Impedance of arm (left) 0.4 2.0 3.4 1.8 -0.8
Arm fat mass (right) 1.3 5.4 7.9 1.7 -2.8
Trunk predicted mass 0.7 4.1 6.2 1.4 -2.5
Standing height 0.8 7.8 9.3 2.5 -3.0
Length of working week for main job 0.9 1.0 1.3 0.8 -1.2
Exposure to tobacco smoke at home 0.5 0.5 0.9 -0.4 0.9
Breastfed as a baby 1.0 1.2 2.0 1.4 -0.7
Tense / ‘highly strung’ 0.2 0.4 0.5 0.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.4 0.3
Hair/balding pattern: Pattern 4 0.6 1.3 1.9 -0.9 1.4
Birth weight of first child 0.7 1.4 1.7 1.0 -1.3
Peak expiratory flow (PEF) 0.3 0.8 1.4 1.2 -0.5
Pulse wave reflection index 0.6 0.7 0.9 -0.7 0.9
Ever highly irritable/argumentative for 2 days 3.5 4.3 4.8 -2.2 1.9
Loud music exposure frequency 0.5 0.5 0.6 0.6 -0.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 1.7 -0.9 1.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 0.9 0.9 -0.9
Blood clot in the leg (DVT) 0.6 0.7 0.9 -0.9 0.8
Medication: Paracetamol 1.2 2.0 2.2 1.3 -1.5
Headache pain in last month 2.3 3.9 4.1 1.9 -2.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.3 -0.5 0.5
Glaucoma (self-reported) 0.6 0.7 0.9 -0.7 0.9
Gout (self-reported) 0.6 0.8 0.9 -1.0 0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.5 0.4 -0.7
Medication: Amlodipine 0.7 1.0 1.4 -1.2 0.7
Medication: Ventolin 100micrograms inhaler 4.6 5.9 6.6 -2.6 2.3
Birth weight 3.3 7.1 8.4 2.9 -2.4
Chronic bronchitis/emphysema (mother) 7.1 8.3 8.6 2.9 -2.8
High blood pressure (siblings) 0.0 0.1 0.1 -0.3 0.1
Forced vital capacity (FVC), Best measure 0.4 1.3 2.3 1.5 -0.6
Body fat percentage 1.1 4.3 5.9 1.6 -2.4
Leg fat percentage (right) 1.0 3.5 5.0 1.4 -2.2
Arm fat-free mass (right) 0.2 1.3 2.5 0.1 -1.6
Exposure to tobacco smoke outside home 1.2 1.6 2.5 0.9 -1.6
Comparative body size at age 10 2.1 5.8 6.3 2.5 -2.3
Number of full brothers 1.4 1.7 2.0 1.2 -1.4
Worry too long after embarrassment 0.6 1.0 1.4 -0.8 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 1.7 -0.8 1.3
Wheeze or whistling in the chest in last year 0.8 1.5 2.0 -1.4 1.0
Number of children fathered 0.3 0.4 0.4 -0.6 0.6
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 2.8 1.5 -1.7
Age at first live birth 0.6 1.1 1.8 1.3 -0.6
Pulse wave peak to peak time 0.1 0.1 0.2 0.4 -0.1
Health satisfaction 0.7 0.9 1.2 -1.1 0.8
Shortness of breath walking on level ground 6.5 7.7 9.3 -3.0 2.5
Qualifications: College or University degree 0.2 0.5 0.9 1.0 -0.3
Eye problems/disorders: None of the above 0.5 0.6 0.8 -0.6 0.9
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.8 0.7 -0.9
Emphysema/chronic bronchitis 1.4 1.6 1.8 -1.2 1.3
Medication for pain relief, constipation, heartburn 2.5 4.3 5.7 -1.7 2.4
Neck or shoulder pain in last month 0.3 0.5 0.6 0.6 -0.8
Medication: Blood pressure 0.1 0.1 0.1 -0.3 0.4
Angina (self-reported) 0.1 0.1 0.1 -0.3 -0.4
Migraine (self-reported) 1.1 1.3 1.8 0.9 -1.4
Medication: Ibuprofen 0.2 0.2 0.5 0.2 -0.7
Medication: Allopurinol 0.0 0.0 0.0 -0.1 -0.1
Medication: Omeprazole 0.2 0.3 0.5 0.3 -0.7
Medication: Seretide 50 evohaler 0.8 1.0 1.3 -0.8 1.2
Mean time to correctly identify matches 0.2 0.4 0.6 0.7 -0.4
Heart disease (mother) 0.4 0.5 0.7 0.8 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 2.0 -1.4 1.0
Whole body fat mass 1.3 5.2 7.9 1.6 -2.8
Leg fat mass (right) 0.9 3.6 5.6 1.2 -2.4
Arm predicted mass (right) 0.3 1.4 2.7 0.2 -1.6
Pulse rate, automated reading 2.2 7.1 7.7 2.8 -2.6
Alcohol intake frequency. 0.1 0.2 0.3 -0.6 0.4
Comparative height size at age 10 1.9 10.3 11.8 3.0 -3.4
Number of full sisters 0.6 0.7 1.3 0.3 -1.2
Suffer from ‘nerves’ 0.3 0.5 0.7 -0.6 0.8
Overall health rating 0.2 0.4 0.7 0.3 -0.8
Chest pain or discomfort 0.3 0.4 0.8 0.3 -0.9
Had major operations 1.8 2.1 2.5 1.3 -1.6
Age at last live birth 0.2 0.3 0.6 0.8 0.0
Family relationship satisfaction 0.2 0.2 0.3 0.6 -0.3
Leg pain on walking 0.4 0.5 0.8 -0.9 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.1 0.4 -0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.3 -0.6 0.2
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 0.3 0.1
Medication: Aspirin 0.2 0.2 0.3 0.4 -0.5
Supplements: Vitamin C 0.4 0.5 0.6 0.8 -0.6
Knee pain experienced in last month 2.4 3.7 4.7 2.2 -1.6
Hypertension (Self-reported) 0.4 1.1 1.6 -1.2 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.1 0.1 0.1 -0.3
Illnesses of father: Heart disease 0.2 0.3 0.6 0.2 -0.7
Illnesses of siblings: Diabetes 1.2 1.5 2.1 0.9 -1.4
Smoking status: Previous 0.0 0.1 0.1 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.1 -0.4
Whole body fat-free mass 0.6 3.4 5.8 1.0 -2.4
Leg fat-free mass (right) 0.4 2.1 3.8 0.6 -1.9
Arm fat percentage (left) 1.1 4.6 6.3 1.7 -2.5
Average weekly red wine intake 0.0 0.1 0.1 -0.2 0.3
Handedness (chirality/laterality): Left-handed 1.5 1.9 2.4 1.6 -1.1
Mood swings 0.3 0.5 0.8 0.5 -0.9
Loneliness, isolation 1.0 1.4 1.7 -1.0 1.3
Long-standing illness, disability or infirmity 0.5 0.8 1.6 -1.3 0.1
Ever had bowel cancer screening 1.5 1.7 2.3 1.5 -1.1
Diabetes diagnosed by doctor 1.5 2.5 3.8 1.1 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.3 -0.5 0.6
Friendships satisfaction 1.7 2.2 2.8 1.7 -1.2
Qualifications: nursing, teaching 0.0 0.1 0.1 0.3 -0.1
Commuting to job workplace: Walk 0.0 0.0 0.0 -0.1 0.2
Eye problems/disorders: Cataract 0.8 0.9 1.1 1.1 -0.9
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 3.9 2.0 -1.7
Medication for cholesterol 1.0 1.5 2.3 1.5 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.4 0.7 -0.4
Back pain experienced in last month 0.2 0.3 0.7 -0.0 -0.8
Mineral and other dietary supplements 0.3 0.4 0.5 -0.6 0.7
Breast cancer (self-reported) 2.6 3.1 3.6 1.9 -1.6
Asthma (self-reported) 3.7 7.3 10.0 -3.2 2.2
Osteoporosis (self-reported) 1.2 1.5 2.7 1.6 -0.5
Osteoarthritis (self-reported) 0.1 0.2 0.2 0.5 -0.3
Medication: Aspirin 0.0 0.0 0.0 0.1 -0.1
Medication: Gliclazide 1.0 1.2 1.3 -1.1 1.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 0.6 0.1
Smoking status: Current 0.2 0.3 0.4 -0.6 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.6 1.3 -0.2
Whole body water mass 0.6 3.4 5.9 1.0 -2.4
Leg predicted mass (right) 0.4 2.3 4.1 0.7 -2.0
Arm fat mass (left) 1.1 4.5 6.7 1.5 -2.6
Number of self-reported non-cancer illnesses 0.2 0.3 0.7 0.0 -0.8
Average weekly champagne plus white wine intake 0.6 0.9 1.7 0.1 -1.3
Miserableness 1.7 3.0 3.5 -1.9 1.6
Guilty feelings 0.5 0.7 0.9 0.9 -0.8
Wears glasses or contact lenses 1.2 1.4 1.6 1.2 -1.1
Ever taken oral contraceptive pill 0.0 0.0 0.1 0.2 -0.2
Hearing aid user 0.2 0.2 0.3 0.5 -0.3
Mother’s age at death 0.2 0.3 0.5 -0.7 0.2
Financial situation satisfaction 0.0 0.0 0.1 0.3 0.0
Tinnitus: Yes, now most or all of the time 0.8 1.0 1.5 -1.2 0.6
Commuting to job workplace: Public transport 0.1 0.1 0.1 0.4 0.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.4 -0.7 0.5
Medication: Blood pressure 1.0 1.9 2.5 -1.6 1.1
Pain type(s) experienced in last month: Hip pain 1.5 1.9 2.5 1.2 -1.6
Supplements: Fish oil (including cod liver oil) 1.9 2.5 2.7 1.5 -1.6
High cholesterol (Self-reported) 0.1 0.1 0.2 -0.3 -0.4
Medication: Bendroflumethiazide 0.5 0.7 1.0 -0.7 1.0
Medication: Paracetamol 1.0 1.5 1.7 1.1 -1.3
Medication: Lisinopril 0.2 0.3 0.4 -0.5 0.6
Medication: Atorvastatin 1.4 1.7 2.0 1.2 -1.4
Illnesses of father: High blood pressure 0.0 0.0 0.0 0.1 0.0
Alcohol drinker status: Never 0.4 0.5 0.5 -0.7 0.7
Ever smoked 0.0 0.1 0.1 0.3 0.2
Basal metabolic rate 0.8 4.2 6.8 1.3 -2.6
Leg fat percentage (left) 0.9 3.3 4.8 1.4 -2.2
Arm fat-free mass (left) 0.5 2.4 4.2 0.7 -2.0
Number of operations (self-reported) 3.0 4.5 4.8 2.1 -2.2
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.8 0.2
Irritability 1.3 2.1 3.1 1.1 -1.8
Risk taking 0.4 0.7 0.8 -0.9 0.7
Ever had prostate specific antigen (PSA) test 2.7 3.1 4.5 2.1 -1.3
Fractured/broken bones in last 5 years 0.2 0.3 0.5 0.7 -0.1
Age started oral contraceptive pill 0.4 0.5 0.8 0.5 -0.9
Diastolic blood pressure, automated reading 1.0 3.1 4.0 -2.0 1.5
Ever depressed for a whole week 0.2 0.2 0.4 0.7 -0.2
Unable to work because of sickness or disability 0.7 0.9 1.2 0.8 -1.1
Commuting to job workplace: Cycle 1.8 2.2 2.4 1.4 -1.6
Myopia 0.2 0.3 0.5 -0.4 0.7
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.0 1.4 -0.8
Cholesterol lowering medication 0.2 0.3 0.5 -0.2 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 0.7 0.9 -0.8
Pain experienced in last month 4.4 7.3 7.3 -2.7 2.7
Supplements: Calcium 0.2 0.2 0.2 0.4 -0.4
Basal cell carcinoma (self-reported) 1.5 1.8 1.9 1.4 -1.3
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.0 -1.7 0.9
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 1.8 -1.3 1.2
Heart disease (siblings) 0.0 0.1 0.1 -0.2 -0.3
Alcohol drinker status: Previous 0.0 0.0 0.1 0.1 -0.3
Pack years of smoking 0.9 1.3 2.2 0.6 -1.5
Impedance of whole body 0.1 0.5 1.1 1.0 0.1
Leg fat mass (left) 0.9 3.4 5.4 1.2 -2.3
Arm predicted mass (left) 0.5 2.6 4.4 0.9 -2.1