Hub : Genes

MYO18A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1920	0.0720	7.3e-04	0.126	NA	0.048	NA	0.115	2.1e-07	NA	1.2e-03	NA	7.3e-07
2	GTEx	Cells Transformed fibroblasts	0.1380	0.0700	4.5e-03	0.012	NA	0.002	NA	0.012	4.3e-02	NA	2.3e-01	NA	4.1e-02
3	GTEx	Esophagus Mucosa	0.2170	0.0610	1.4e-04	0.138	NA	0.088	NA	0.132	1.6e-09	NA	1.7e-06	NA	4.2e-09
4	GTEx	Heart Atrial Appendage	0.1290	0.0600	6.3e-03	0.064	NA	0.017	NA	-0.003	8.2e-04	NA	5.7e-02	NA	4.7e-01
5	GTEx	Nerve Tibial	0.4359	0.0616	4.3e-12	0.332	NA	0.281	NA	0.312	3.4e-24	NA	3.9e-20	NA	1.4e-22
6	GTEx	Skin Not Sun Exposed Suprapubic	0.6650	0.0630	1.6e-09	0.262	NA	0.401	NA	0.395	1.2e-14	NA	1.9e-23	NA	5.1e-23
7	GTEx	Skin Sun Exposed Lower leg	0.5140	0.0540	0.0e+00	0.269	NA	0.370	NA	0.397	2.5e-22	NA	4.1e-32	NA	6.8e-35
8	GTEx	Testis	0.2640	0.0690	1.0e-07	0.146	NA	0.194	NA	0.192	5.2e-07	NA	5.3e-09	NA	6.3e-09
9	GTEx	Thyroid	0.3640	0.0770	3.0e-06	0.156	NA	0.132	NA	0.131	5.8e-12	NA	2.7e-10	NA	3.2e-10
10	NTR	Blood	0.0111	0.0060	9.4e-03	0.000	0.003	0.001	0.003	0.000	3.0e-01	0.028	1.8e-01	0.039	3.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	4.2	0.1	0.5	0.7	-2.1	0.2	0.1	-0.1	1.7	1.1	1.5
Bipolar Disorder or Schizophrenia	0.6	1.4	5.4	2.3	2.1	0.1	-0.8	-0.5	-0.4	-0.8	1.5	0.2	0.7
Depressed Affect (Nagel 2018)	0.4	0.7	2.6	-1.1	-0.7	-0.1	-1.6	-0.0	-0.6	-0.2	1.3	0.5	0.9
Depression (Nagel 2018)	1.3	2.0	6.7	-0.7	0.3	-0.3	-2.5	-0.5	-0.8	-0.4	2.4	0.2	2.6
Intelligence (Savage-Jansen 2018)	0.9	2.9	12.4	-0.8	-1.2	-2.1	0.9	-1.0	-1.4	-1.3	-1.1	-1.8	-3.5
Neuroticism (Nagel 2018)	0.3	0.7	1.2	-1.1	-1.0	-0.9	-0.8	-0.8	-1.1	-1.0	0.2	-0.7	0.2
Schizophrenia (2018)	0.7	1.5	7.6	2.8	2.3	-0.4	0.6	-0.7	-0.4	-0.8	0.5	-0.6	-0.3
Schizophrenia vs Biploar Disorder	1.2	1.5	3.5	0.6	0.8	-1.1	1.8	-0.8	-0.9	-0.9	-1.4	-1.4	-1.9
Worry (Nagel 2018)	0.7	1.4	2.7	-0.1	0.6	-1.5	1.1	-1.5	-1.0	-1.6	-1.3	-1.6	-0.4
Alzheimer’s Disease (in mother)	0.5	0.6	2.4	0.4	-0.4	-0.0	-1.3	-0.7	-0.6	-0.7	1.6	0.3	0.1
Alzheimer’s Disease (in father)	4.1	4.4	6.8	2.1	2.0	2.4	-1.8	2.1	1.7	1.8	2.6	2.5	1.7
Alzheimer’s Disease (including proxy)	1.5	2.1	7.2	1.6	0.7	1.5	-1.8	0.7	0.6	0.6	2.7	1.7	1.1
Crohns Disease (2017)	0.5	1.1	4.6	-0.9	0.2	0.2	2.1	-0.0	-0.9	-0.6	-2.1	-0.4	-0.4
Irritable Bowel Disease (IBD)	1.1	2.6	11.0	-0.8	0.5	-0.8	3.3	-0.6	-1.1	-0.9	-2.8	-1.1	-1.4
Ulcerative Colitis (UC)	1.1	2.1	7.4	-0.4	0.0	-1.2	2.7	-0.6	-0.7	-0.6	-2.2	-1.3	-2.1
Major Depression (MDD)	1.2	1.5	7.3	-1.5	-0.1	0.2	-1.5	-0.1	-1.1	-0.7	1.1	0.4	2.7
Reaction Time	1.0	1.8	4.7	-2.2	-1.7	0.5	1.7	0.8	0.6	0.9	-1.9	0.5	-1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	7.6	-0.3	-1.8	-0.6	-0.5	0.1	0.0	0.0	0.1	-0.7	-2.8
Breast Cancer	0.7	1.6	2.4	-1.4	-0.0	1.3	1.2	1.6	1.5	1.5	-1.2	1.3	-0.8
Ovarian Cancer	3.5	4.6	11.9	3.5	2.9	2.2	2.0	2.0	2.1	1.8	-0.4	1.3	1.9
Prostate Cancer	1.5	2.0	6.0	2.0	1.2	-0.5	2.1	-0.4	0.5	0.1	-2.5	-0.6	-1.8
Age at First Birth	1.0	1.5	5.8	0.5	0.1	-0.7	2.1	-0.5	-0.7	-0.6	-1.4	-0.8	-2.4
Bipolar Disorder (2011)	2.0	2.0	8.5	0.0	1.5	1.6	-0.9	1.2	0.6	0.0	1.2	1.4	2.9
Body Mass Index (BMI) (2010)	0.3	0.5	1.4	0.2	0.4	-0.7	0.8	-0.5	-0.7	-0.7	-0.4	-1.2	0.6
Coronary Artery Disease (CAD)	0.8	1.0	3.1	-0.1	-0.1	-0.6	1.5	-0.5	0.4	0.0	-1.8	-1.0	-1.6
Crohns Disease (2012)	0.6	1.0	1.9	-1.3	-1.0	1.4	0.9	1.1	0.7	0.9	-1.0	1.0	-0.3
Mean Putamen Volume	0.9	1.0	2.5	1.0	1.6	-0.6	1.5	-0.1	1.0	0.1	-1.2	-0.6	1.1
Fasting Glucose	0.3	0.3	1.1	0.1	0.7	1.0	-0.4	0.9	1.0	0.2	-0.1	0.1	-0.0
HbA1C	0.7	0.8	4.8	0.3	2.2	0.6	-0.7	0.6	0.4	0.4	0.2	0.9	0.9
HDL Cholesterol	0.2	0.3	1.0	0.4	0.4	0.4	0.7	0.1	1.0	0.6	-0.4	-0.0	-0.5
LDL Cholesterol	1.6	2.6	7.3	-0.8	2.2	1.0	-0.7	1.3	1.2	1.4	1.5	2.1	2.7
Lupus	0.7	1.1	4.1	0.4	-0.2	-0.0	-2.0	0.0	-0.8	-0.6	1.7	-0.7	1.5
Neuroticism (2016)	1.4	2.0	5.4	-2.3	-1.0	-1.0	0.0	-1.2	-1.9	-1.6	-0.9	-1.9	0.3
Primary Biliary Cirrhosis	0.4	0.6	2.2	1.5	0.8	1.0	-0.5	0.7	0.5	0.5	0.3	0.9	0.3
Rheumatoid Arthritis	0.5	0.6	3.0	0.2	-0.3	0.3	-1.7	0.4	0.5	0.6	1.4	0.5	0.5
Schizophrenia (2014)	1.0	2.1	7.4	2.7	2.5	-1.1	1.1	-1.3	-0.9	-1.3	0.0	-0.8	-0.6
Triglycerides	0.3	0.6	2.2	-0.2	0.3	-0.1	-0.7	-0.2	-0.5	-0.6	1.5	-0.1	1.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	0.5	0.0	-1.1	0.5	-0.6	-1.5	0.0	-0.7	-0.7	-0.8
Ulcerative Colitis	1.0	1.5	5.5	-0.5	0.7	0.4	2.3	0.8	1.2	1.1	-1.6	1.0	-1.2
Blood Eosinophil Count	0.7	5.2	11.2	-1.6	-3.2	2.3	-3.4	2.5	2.3	2.2	1.5	1.8	1.0
Blood Platelet Count	13.0	150.9	729.0	-3.1	1.7	-4.0	18.4	-2.0	0.9	-1.0	-19.4	-5.5	-27.0
Blood Red Count	1.2	11.4	56.4	0.4	7.5	-4.0	1.5	-2.5	-3.0	-2.9	-2.0	-2.2	2.7
Blood White Count	0.9	6.5	20.3	-1.2	-2.2	4.5	-1.9	2.4	3.1	2.9	1.0	3.2	0.3
Heel T-Score	0.8	6.3	33.4	1.4	-0.3	0.9	5.8	-1.6	-0.4	-1.4	-4.2	-2.2	-0.3
BMI	0.8	4.6	12.6	-1.3	2.1	-3.5	1.5	-2.0	-1.4	-1.9	-3.0	-2.3	0.6
Height	0.2	2.9	12.1	0.1	-1.9	2.0	1.5	0.0	1.3	0.5	-3.5	-1.7	-1.5
Waist Hip Ratio (WHR)	0.4	1.9	5.4	-1.4	0.8	-0.3	2.0	-0.2	0.9	0.6	-2.3	-0.4	-2.3
Systolic Blood Pressure	0.1	0.4	2.1	-0.2	1.4	-0.5	0.3	-0.1	-0.5	-0.3	-0.6	0.3	-0.7
Smoking Status	1.2	2.8	9.3	0.7	2.6	-1.5	-0.4	-2.0	-1.0	-1.5	1.2	0.0	3.1
Allergy or Eczema	0.7	1.9	6.2	-1.6	-2.5	-0.2	0.1	0.1	-1.3	-0.9	-0.9	-1.4	-2.2
Cardiovascular Disease	0.4	1.5	5.6	-0.8	2.4	-1.9	1.5	-0.5	0.3	-0.0	-1.4	-0.7	0.1
Hypothyroidism (self reported)	1.3	3.1	16.4	-1.8	-2.1	-0.8	-4.0	0.2	-0.4	-0.2	2.2	-0.4	0.7
Respiratory disease	1.0	2.3	10.4	-0.1	-2.2	0.8	-3.2	0.3	-0.1	0.2	2.6	0.1	0.3
Type 2 Diabetes (T2D) (2018)	0.8	1.4	6.8	0.8	0.8	-0.5	1.4	-0.2	-0.9	-1.0	-1.2	-0.9	-2.6
Lung FEV1/FVC ratio	1.5	7.7	29.7	-0.4	0.9	-4.8	1.9	-0.7	-1.2	-0.7	-3.8	-1.6	-5.5
Lung FVC	0.4	2.3	9.6	1.9	0.9	0.1	0.7	-1.0	-1.3	-1.2	2.0	0.1	3.1
Neuroticism	0.3	0.7	1.4	-0.8	-0.6	-0.8	-0.2	-1.0	-1.2	-1.2	-0.4	-0.9	0.4
Chronotype (morning person)	0.4	1.0	5.2	0.4	1.7	0.6	0.5	0.6	0.4	0.4	-0.2	0.3	2.3
Hair Pigment	0.0	1.0	4.9	-1.1	-0.8	0.8	0.6	-0.3	-0.7	-1.0	0.6	-0.2	2.2
Tanning	0.3	3.8	14.6	0.7	0.8	0.4	-3.5	0.1	0.5	0.3	3.8	1.4	2.7
Hand grip strength (left)	0.1	0.3	1.0	0.6	0.9	0.3	1.0	0.2	0.5	-0.1	0.1	-0.4	0.8
Number of treatments/medications taken	0.2	0.3	1.4	0.0	1.1	-0.5	-0.1	0.2	0.0	0.1	-0.1	-0.1	1.2
Average weekly spirits intake	1.0	1.3	2.7	0.8	-0.2	1.7	0.6	1.4	1.5	1.6	-0.0	1.5	0.4
Sensitivity / hurt feelings	0.8	1.4	3.0	-0.4	-1.4	-0.8	0.2	-1.3	-1.5	-1.7	-0.4	-1.7	0.9
Frequency of depressed mood in last 2 weeks	1.6	2.2	7.2	-0.9	0.4	0.1	-2.7	0.1	-0.4	0.1	2.5	0.6	2.6
Hearing difficulty/problems: Yes	0.5	0.7	3.1	-0.1	-1.8	-0.3	-1.0	0.1	-0.4	-0.2	0.6	0.1	-1.6
Relative age of first facial hair	0.5	1.0	2.1	1.3	1.0	0.7	1.4	0.9	0.9	1.0	-1.0	0.6	0.5
Other serious medical condition/disability diagnosed by doctor	3.3	4.3	8.2	1.2	1.9	-2.2	-2.0	-2.1	-2.5	-2.4	1.8	-0.9	2.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	3.8	0.1	-1.9	0.2	0.1	0.1	0.2	0.3	0.2	-0.3	-0.7
Ever had hysterectomy (womb removed)	2.7	3.0	7.3	-1.6	-0.8	-2.6	0.0	-2.7	-2.1	-2.5	0.3	-1.4	0.1
Systolic blood pressure, automated reading	0.3	0.9	4.4	0.4	2.1	-1.0	0.7	-0.7	-0.5	-0.7	-0.9	-0.6	-0.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.8	-1.3	-1.2	-1.0	0.4	-1.0	-1.2	-0.9	-0.1	-0.7	-0.1
Angina	0.6	0.8	5.1	-2.3	0.2	-0.8	-0.6	-0.0	-0.1	-0.1	-0.5	0.1	1.2
Medication for hormone replacement therapy	0.3	0.4	0.8	0.4	0.3	-0.5	0.0	-0.7	-0.9	-0.8	0.9	-0.3	0.4
Vitamin and mineral supplements	2.1	2.9	6.5	-2.0	-1.0	-1.8	-1.4	-2.2	-2.6	-2.1	0.5	-1.6	0.0
Supplements: Zinc	0.9	1.0	1.7	1.3	1.1	-1.1	1.3	-0.5	-0.5	-0.8	-1.1	-1.2	0.2
Medication: Co-codamol	1.2	1.3	3.7	0.5	1.4	-1.1	-0.7	-1.3	-1.0	-0.9	1.0	-1.1	1.9
Medication: Metformin	1.1	1.6	6.2	0.2	-0.1	-1.1	2.0	-0.7	-0.4	-0.5	-1.6	-1.2	-2.5
Diabetes (father)	1.4	1.8	3.3	0.3	0.3	-1.7	1.6	-1.5	-0.9	-1.0	-1.8	-1.3	-1.6
Diabetes (mother)	0.7	0.9	2.8	0.9	1.5	-0.2	0.9	0.2	0.4	0.4	-1.3	-0.1	-1.7
Severe depression (siblings)	1.1	1.2	8.9	0.7	3.0	-0.4	-0.2	-0.4	-0.0	-0.2	0.3	0.2	1.6
Pack years adult smoking proportion	1.9	3.0	13.2	0.1	0.5	-0.2	-2.6	-0.2	-0.1	-0.1	3.0	1.0	3.6
Impedance of leg (right)	0.1	0.6	2.7	0.2	0.5	-0.1	-1.4	0.0	-0.1	0.5	1.6	0.5	-0.0
Leg fat-free mass (left)	0.2	0.9	6.1	-0.5	-0.3	-0.0	1.1	-0.2	0.1	-0.3	-2.5	-1.1	-0.2
Trunk fat percentage	0.9	3.6	16.8	-1.6	0.2	-1.8	2.6	-0.7	-0.2	-0.3	-4.1	-1.5	-2.2
Hand grip strength (right)	0.2	0.6	2.9	0.6	1.0	-0.0	1.7	-0.3	0.0	-0.5	-0.1	-0.5	0.8
Townsend deprivation index at recruitment	1.9	2.6	9.3	-0.4	0.8	-1.0	-2.4	-1.4	-1.3	-1.1	2.2	-0.6	3.0
Current tobacco smoking	1.0	1.7	4.9	1.6	1.7	-0.7	-0.9	-1.0	-0.3	-0.5	1.7	1.1	2.2
Average weekly fortified wine intake	0.5	0.6	1.6	-0.9	-1.0	0.7	0.7	0.4	1.3	0.9	-0.5	0.4	-0.0
Maternal smoking around birth	1.0	1.5	5.0	0.0	-0.1	1.3	-1.6	1.0	0.5	0.2	1.8	1.2	2.2
Fed-up feelings	0.5	0.9	3.0	-0.7	-0.9	0.6	-1.7	0.6	-0.1	0.4	1.2	0.7	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	8.9	0.0	0.3	-0.5	-2.5	-0.6	-0.6	-0.5	1.7	-0.4	3.0
Relative age voice broke	0.2	0.4	1.4	0.6	-0.0	0.8	0.4	0.8	-0.2	0.2	0.3	0.5	1.2
Taking other prescription medications	0.4	0.6	2.5	-0.3	-0.7	-1.6	-0.8	-0.8	-0.6	-0.6	0.4	-0.9	0.3
Age when periods started (menarche)	0.8	2.0	5.6	-0.6	0.1	1.9	-0.8	1.8	1.6	1.7	0.7	2.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.7	0.4	-0.8	-0.3	-1.2	-0.4	-0.1	-0.4	1.9	0.2	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	0.1	-0.1	0.7	1.2	-0.5	-0.4	-0.5	-0.9	-0.9	1.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.2	0.5	1.5	0.9	1.8	1.1	0.5	0.9	-0.8	0.4	0.2
Qualifications: CSEs or equivalent	0.2	0.3	1.3	-1.1	0.0	-0.1	-0.4	-0.3	-0.1	-0.4	-0.4	0.7	0.3
Serious illness, injury or assault to yourself	3.0	3.7	8.7	-0.8	0.1	-2.8	0.2	-3.0	-2.4	-2.8	-0.5	-2.0	1.2
High blood pressure	0.5	1.4	3.5	-0.7	1.3	-1.1	1.9	-0.0	0.9	0.9	-1.6	-0.5	-1.6
Hayfever, allergic rhinitis or eczema	0.9	1.9	7.9	-0.9	-2.0	-0.5	0.7	0.0	-1.1	-0.9	-1.2	-1.3	-2.8
Multivitamins +/- minerals	1.5	1.9	5.1	1.1	-0.5	1.6	0.1	2.3	2.0	2.0	0.0	1.2	-0.8
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.1	0.9	-0.3	-0.4	0.3	0.2	0.3	-0.0	0.5	0.8
Supplements: Glucosamine	1.7	2.2	8.6	1.5	1.8	0.1	2.9	0.2	1.1	0.7	-2.1	0.1	-1.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	-0.1	-0.9	0.9	-1.5	1.2	0.8	0.8	0.8	1.4	0.6
Medication: Atenolol	1.6	2.0	5.5	-0.5	2.0	-1.4	2.1	-0.9	-0.4	-0.6	-2.3	-1.5	0.3
Medication: Levothyroxine sodium	1.3	2.2	7.1	-2.2	-2.1	-0.8	-2.7	-0.6	-0.5	-0.4	1.8	-0.6	0.9
Sitting height	0.2	1.1	6.4	0.4	-2.5	0.3	-1.1	-0.5	-0.7	-0.6	-0.1	-1.4	-0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-0.1	0.6	1.2	-0.2	1.4	1.0	1.1	-0.1	0.7	0.2
High blood pressure (mother)	0.4	0.6	2.1	-0.9	0.6	-1.0	0.1	-0.4	-0.4	-0.4	-1.2	-1.4	0.0
Body mass index (BMI)	0.6	2.6	9.2	-1.2	1.0	-2.3	1.9	-1.1	-0.8	-1.1	-3.0	-1.6	-0.2
Impedance of leg (left)	0.0	0.1	0.4	0.3	0.4	-0.2	-0.2	-0.4	-0.2	0.2	0.6	0.2	-0.5
Leg predicted mass (left)	0.2	0.9	6.2	-0.4	-0.2	-0.1	1.1	-0.3	0.0	-0.4	-2.5	-1.2	-0.2
Trunk fat mass	1.0	4.3	19.6	-1.2	0.4	-2.0	2.8	-1.1	-0.5	-0.8	-4.4	-2.0	-2.0
Waist circumference	1.6	6.0	20.0	-1.7	1.2	-2.8	3.3	-1.9	-1.2	-1.5	-4.5	-2.5	-1.9
Number of incorrect matches in round	1.2	2.0	9.0	0.2	2.1	1.4	0.4	0.5	1.3	0.5	-0.5	1.4	3.0
Past tobacco smoking	1.1	2.0	5.5	-0.3	-2.3	1.8	-1.4	2.0	0.9	1.4	1.0	1.1	-0.3
Alcohol usually taken with meals	0.4	0.6	1.7	-1.3	0.1	0.9	0.3	0.7	1.3	1.2	0.0	-0.1	0.2
Nervous feelings	0.9	1.8	4.5	0.6	1.7	-1.2	2.1	-1.1	-1.0	-0.9	-1.8	-1.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	-1.1	0.1	1.1	-1.3	1.2	1.0	1.2	0.9	1.1	1.0
Hearing difficulty/problems with background noise	1.2	1.9	4.1	-0.2	-0.1	-2.0	1.3	-1.8	-1.6	-1.8	-0.8	-1.8	-0.8
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	1.1	-0.1	0.8	-0.3	0.7	1.0	0.7	0.5	1.2	-0.2
Had menopause	0.5	0.6	2.2	-0.7	-0.6	-0.8	0.8	-0.1	0.3	0.4	-1.5	-0.9	-0.8
Had other major operations	0.4	0.5	1.9	0.5	0.2	-0.5	-0.6	-0.4	-0.4	-0.3	1.0	-0.7	1.4
Forced vital capacity (FVC)	0.2	0.9	3.0	1.5	-0.8	1.7	0.1	0.1	0.6	0.4	0.5	0.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.5	0.0	-0.3	-0.6	1.8	-1.6	-1.7	-1.8	-1.3	-2.1	0.8
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.9	-0.3	1.5	-2.0	-1.0	-1.6	-1.6	-1.4	0.4	-1.4	1.0
Qualifications: None of the above	0.1	0.2	0.6	-0.8	-0.5	0.1	0.4	-0.2	0.3	0.3	-0.1	0.0	0.6
Financial difficulties in last 2 years	0.5	0.7	1.2	0.3	0.0	0.9	-1.1	0.8	0.9	0.8	1.1	0.9	0.7
Mouth/teeth dental problems	1.4	2.2	11.3	-0.6	-1.9	0.8	1.0	0.9	0.8	0.9	-1.7	-0.0	-3.4
Heart attack	1.2	1.5	3.2	-0.7	1.4	0.5	-1.8	1.3	1.2	0.8	1.1	1.6	1.3
Allergy	0.6	1.5	5.1	0.9	1.8	0.6	0.4	0.4	1.2	1.1	0.1	1.5	2.3
Pain all over the body in last month	2.3	2.4	4.4	-1.0	-0.2	-2.0	-1.8	-2.1	-1.8	-1.8	1.1	-1.2	1.7
Diabetes (self-reported)	1.8	2.7	8.4	-0.4	-0.2	-2.0	1.3	-1.4	-1.8	-1.5	-1.5	-1.8	-2.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	5.0	-0.6	-2.2	-0.1	0.3	0.0	-0.8	-0.6	-0.0	-0.4	-1.9
Medication: Ramipril	0.5	0.7	2.5	0.0	1.6	-0.9	0.4	-0.8	-1.0	-1.0	0.6	-0.1	-0.1
Medication: Simvastatin	0.6	0.9	6.2	0.1	2.5	-0.5	-0.1	-0.0	0.1	0.1	0.5	0.4	1.5
Fluid intelligence score	0.4	0.9	3.1	-0.1	-1.0	-1.4	-0.1	-0.6	-0.7	-0.6	-0.0	-1.2	-1.8
Illnesses of siblings	3.8	5.4	16.5	0.9	-1.4	4.1	-0.6	2.7	2.9	2.5	1.1	3.2	0.5
Neuroticism score	0.3	0.6	1.5	-0.7	-0.2	-0.4	-0.5	-0.7	-1.2	-1.1	-0.1	-0.8	0.9
Weight	0.7	3.2	14.8	-0.6	0.7	-1.6	2.4	-1.2	-0.5	-1.1	-3.9	-2.1	-0.7
Impedance of arm (right)	1.0	4.7	13.6	-2.2	-3.4	2.0	0.8	1.6	1.4	2.1	-1.4	1.3	-3.7
Arm fat percentage (right)	1.1	4.5	19.7	-2.4	0.0	-1.9	2.9	-0.7	-0.6	-0.6	-4.4	-1.4	-2.1
Trunk fat-free mass	0.3	2.0	4.9	1.0	1.2	-0.9	1.3	-1.4	-0.8	-1.5	-2.1	-2.2	0.8
Hip circumference	1.0	4.4	16.4	-0.9	0.9	-2.2	2.7	-1.8	-1.1	-1.7	-4.1	-2.4	-1.0
Time employed in main current job	2.5	2.9	6.5	1.3	0.6	2.5	-0.2	2.5	2.4	2.3	0.5	1.7	0.1
Alcohol intake versus 10 years previously	0.7	1.0	4.8	-2.2	-0.3	0.2	-0.4	0.2	-0.3	-0.1	0.7	1.0	1.9
Father’s age at death	0.6	0.9	3.5	-0.7	-1.9	0.8	0.4	0.6	0.6	0.8	-0.6	0.4	-1.4
Worrier / anxious feelings	1.8	3.5	5.9	0.2	1.7	-2.3	1.1	-2.4	-2.2	-2.4	-1.2	-2.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	-0.4	0.5	-1.5	-0.5	-1.1	-1.1	-0.9	-0.2	-1.2	1.0
Falls in the last year	1.0	1.3	4.0	0.4	1.2	-1.1	-0.3	-1.5	-1.4	-1.4	0.5	-0.1	2.0
Hair/balding pattern: Pattern 3	0.6	0.9	3.5	0.0	0.4	-1.3	0.2	-1.1	-0.7	-1.2	-0.3	-1.9	0.2
Number of live births	0.7	1.0	2.7	0.2	0.0	-1.2	-0.6	-1.4	-1.4	-1.6	0.5	-1.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.7	0.7	-1.3	0.4	0.6	0.1	0.0	-0.0	-0.9	-0.3	-0.3
Pulse rate	1.9	3.2	7.1	1.1	-0.2	-2.5	-1.0	-2.5	-2.4	-2.7	0.6	-1.9	-0.5
Happiness	1.5	1.8	3.1	0.8	0.7	-1.5	-1.0	-1.7	-1.4	-1.5	1.6	-1.1	1.8
Noisy workplace	0.5	0.6	3.9	1.0	0.4	0.4	0.7	-0.2	0.1	-0.0	-0.0	0.2	2.0
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.7	0.3	1.2	-1.3	1.8	-1.0	-1.5	-1.3	-1.9	-1.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.8	-1.0	-0.4	-0.7	1.3	-0.5	-1.1	-0.9	-1.9	-0.5	-1.5
Mouth/teeth dental problems: Dentures	1.0	1.7	3.9	-0.9	-0.9	-1.7	-1.3	-2.0	-1.3	-1.3	1.3	-1.3	0.5
Asthma	2.1	4.2	19.7	-1.2	-2.5	0.7	-4.4	0.1	-0.3	-0.1	3.5	-0.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	5.1	6.4	13.5	0.1	-1.0	3.5	0.5	3.6	3.6	3.7	-0.5	3.4	0.3
Medication: Cholesterol lowering	1.7	2.6	5.5	0.2	2.3	0.9	-2.0	1.4	1.8	1.4	1.7	1.7	1.7
Depression (self-reported)	2.2	2.6	6.4	0.3	-0.2	-2.5	-0.0	-2.3	-2.2	-2.5	0.2	-1.8	-0.3
Medication: Lansoprazole	0.7	0.7	4.0	2.0	0.3	-0.4	0.3	-0.4	0.3	-0.0	-0.3	-0.3	-1.6
Prospective memory result	1.1	1.3	9.1	0.0	1.1	-0.4	-0.7	-1.1	-0.3	-0.8	0.5	-0.2	3.0
Lung cancer (father)	0.2	0.3	0.6	0.6	0.0	-0.5	-0.8	-0.8	-0.0	-0.4	0.6	-0.4	0.1
Illnesses of mother	0.8	1.0	3.7	-0.2	-1.1	1.9	0.5	1.0	0.9	0.9	0.1	1.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.5	1.2	-1.1	0.5	0.8	0.4	0.1	-0.1	-0.9	-0.5	-0.9
Pulse wave Arterial Stiffness index	2.0	2.4	6.3	0.2	-0.9	-1.7	-0.8	-1.7	-2.3	-2.5	1.0	-2.0	-0.1
Impedance of arm (left)	0.8	3.9	9.6	-1.9	-3.1	2.1	0.5	1.7	1.6	2.3	-1.1	1.4	-2.8
Arm fat mass (right)	1.0	3.9	19.2	-1.6	0.4	-1.8	2.8	-0.7	-0.5	-0.7	-4.4	-1.6	-1.5
Trunk predicted mass	0.3	1.9	4.7	1.1	1.2	-0.9	1.3	-1.4	-0.8	-1.4	-2.1	-2.2	0.8
Standing height	0.2	1.8	6.7	1.0	-1.0	1.2	1.7	-0.3	0.5	0.0	-2.6	-1.6	-1.4
Length of working week for main job	0.3	0.3	0.9	0.5	0.7	0.6	0.1	0.3	0.2	0.1	-0.1	0.7	-1.0
Exposure to tobacco smoke at home	1.3	1.5	4.7	-0.3	-0.4	1.6	-1.1	1.4	1.1	1.5	0.6	2.2	0.6
Breastfed as a baby	1.0	1.3	3.3	0.0	-0.3	-1.7	0.1	-1.4	-1.8	-1.6	0.3	-1.5	0.0
Tense / ‘highly strung’	0.4	0.6	1.7	1.3	1.3	-0.8	-0.4	-0.8	-0.3	-0.6	0.3	-0.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.9	0.2	1.3	-2.0	-1.0	-1.6	-1.6	-1.4	0.9	-0.4	1.2
Hair/balding pattern: Pattern 4	0.5	1.3	3.1	-0.2	0.8	1.4	0.7	1.3	1.1	1.4	-1.2	0.6	1.8
Birth weight of first child	0.8	1.4	3.7	1.8	-0.3	0.4	1.9	-0.1	0.9	0.1	-1.8	-1.0	-1.3
Peak expiratory flow (PEF)	1.5	3.4	12.9	-1.3	-0.4	-1.7	2.7	-0.7	-1.1	-1.2	-3.6	-1.8	-1.5
Pulse wave reflection index	0.4	0.5	1.2	0.6	0.9	0.5	-0.5	0.7	0.2	0.3	1.1	0.9	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.3	-0.5	-0.5	0.7	-1.5	0.5	-0.1	0.1	1.0	0.7	-0.0
Loud music exposure frequency	0.5	0.5	2.0	0.2	0.4	-0.5	1.4	-0.6	-0.2	-0.4	-1.1	-0.6	-0.9
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	7.5	1.5	1.4	-2.7	1.3	-2.6	-2.3	-2.5	-1.2	-2.1	-0.7
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	13.1	1.6	3.6	0.1	0.4	-0.3	-0.3	-0.6	0.3	0.4	3.0
Blood clot in the leg (DVT)	0.6	0.8	4.8	0.5	-0.4	-0.3	-0.7	0.4	1.2	0.5	0.5	-0.4	-2.2
Medication: Paracetamol	0.8	1.3	3.5	-0.1	-0.4	1.0	1.0	1.0	1.7	1.5	-1.9	0.7	0.3
Headache pain in last month	0.7	1.1	3.3	-0.6	-1.8	1.4	-0.8	1.2	0.9	1.0	0.4	0.8	1.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.2	0.2	-2.1	-0.5	0.1	-1.5	-1.4	-1.3	-0.3	-1.5	-0.7
Glaucoma (self-reported)	0.5	0.6	2.3	0.5	0.9	0.2	1.1	0.3	0.3	0.4	-1.5	-0.2	-0.9
Gout (self-reported)	3.7	5.1	11.0	-0.5	0.1	-2.5	1.6	-2.2	-3.0	-2.4	-2.5	-2.2	-3.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	9.2	-1.7	-1.8	-0.9	-3.0	-0.2	-0.5	-0.4	1.3	-0.5	-0.0
Medication: Amlodipine	0.6	0.9	5.7	-2.4	-0.6	-0.8	-0.1	-0.3	-0.7	-0.5	-0.1	-0.8	0.7
Medication: Ventolin 100micrograms inhaler	3.0	3.9	9.4	-1.3	-1.7	-2.2	0.4	-2.6	-2.3	-2.4	-0.7	-3.1	-1.2
Birth weight	0.4	0.9	2.3	1.4	-0.2	-0.3	1.5	-0.5	-0.3	-0.8	-1.1	-1.5	0.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	-0.2	0.7	-1.2	-1.0	-0.7	-0.3	-0.4	1.3	-0.5	0.4
High blood pressure (siblings)	3.2	4.6	12.7	-1.2	0.3	-3.6	0.3	-2.4	-3.1	-2.4	-0.8	-3.0	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.9	3.5	1.4	-1.1	1.9	0.1	0.5	0.7	0.3	0.5	0.3	0.9
Body fat percentage	1.0	4.0	16.4	-1.6	0.7	-2.3	2.5	-1.1	-0.7	-0.8	-4.0	-1.7	-1.9
Leg fat percentage (right)	0.8	2.7	8.1	-0.8	2.2	-2.8	1.3	-1.2	-1.0	-1.1	-2.5	-1.5	-0.3
Arm fat-free mass (right)	0.3	1.8	3.8	1.1	1.5	-1.2	0.6	-1.3	-0.7	-1.5	-1.4	-2.0	1.3
Exposure to tobacco smoke outside home	0.2	0.2	0.7	-0.8	-0.3	-0.2	0.4	-0.3	-0.8	-0.4	-0.4	0.5	-0.5
Comparative body size at age 10	1.2	3.3	7.0	-0.1	-2.3	2.2	0.8	2.7	2.6	2.5	-0.5	1.3	-0.9
Number of full brothers	0.3	0.4	1.0	0.7	0.0	-0.4	-0.5	-0.8	-1.0	-0.9	0.9	0.0	0.5
Worry too long after embarrassment	1.4	2.4	6.9	-0.6	-1.6	-0.8	0.0	-1.6	-2.6	-2.4	-0.7	-2.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.5	-0.7	-0.0	-0.8	-1.1	-1.1	-1.1	-1.0	1.1	-0.6	1.6
Wheeze or whistling in the chest in last year	0.9	1.6	5.8	-0.4	0.5	-0.3	-2.1	0.1	0.1	-0.5	2.1	0.3	2.4
Number of children fathered	2.8	3.1	5.6	0.2	-1.5	1.7	-2.4	1.9	1.6	1.6	2.3	2.1	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.9	1.0	0.7	1.1	-0.2	1.4	1.1	1.2	0.8	1.3	0.5
Age at first live birth	0.3	0.5	1.9	0.1	0.8	0.8	0.7	1.4	0.4	0.6	-0.1	0.8	-0.6
Pulse wave peak to peak time	2.1	2.5	6.8	-0.3	0.5	1.8	0.8	1.7	2.5	2.6	-1.1	2.0	-0.1
Health satisfaction	1.6	2.1	6.0	2.0	2.4	-1.6	-0.8	-1.4	-1.1	-1.0	0.9	-1.5	0.9
Shortness of breath walking on level ground	0.6	0.7	5.2	-0.4	1.1	-0.4	0.3	-0.4	-0.2	-0.3	-0.1	0.2	2.3
Qualifications: College or University degree	0.2	0.6	1.6	1.2	0.7	0.1	1.3	0.1	0.1	0.2	-0.7	-1.0	-1.1
Eye problems/disorders: None of the above	0.9	1.1	3.2	-0.2	-1.2	0.8	-1.8	0.9	0.8	0.8	1.5	1.0	0.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	7.3	-0.0	0.8	-0.2	-0.8	-0.4	-0.3	-0.5	0.8	0.1	2.7
Emphysema/chronic bronchitis	1.8	2.0	3.8	1.9	1.2	-1.2	1.5	-1.4	-1.1	-1.3	-1.6	-1.6	-1.0
Medication for pain relief, constipation, heartburn	1.7	2.9	6.7	1.2	1.1	-1.8	-0.1	-2.4	-2.6	-2.4	0.7	-1.6	-1.3
Neck or shoulder pain in last month	0.7	0.9	2.3	1.5	1.5	-1.3	-0.0	-0.8	-0.5	-0.8	0.4	-1.1	0.6
Medication: Blood pressure	0.3	0.6	2.6	-0.6	1.6	-0.2	0.8	0.8	0.6	0.9	-0.6	0.5	0.1
Angina (self-reported)	0.6	0.8	5.3	-2.3	0.1	-0.7	-0.8	-0.0	-0.1	-0.1	-0.3	0.1	1.3
Migraine (self-reported)	0.8	1.0	4.7	-1.6	-2.2	0.9	0.3	0.6	0.4	0.7	-0.8	0.3	-0.7
Medication: Ibuprofen	3.7	4.4	9.3	-1.1	-1.2	3.0	-0.1	3.0	2.7	2.8	-0.3	2.8	0.7
Medication: Allopurinol	2.1	2.8	6.7	-0.3	0.3	-2.2	0.6	-1.9	-2.2	-1.8	-1.4	-1.6	-2.6
Medication: Omeprazole	0.2	0.2	1.1	-1.1	-1.1	-0.3	-0.0	-0.1	-0.1	-0.3	-0.0	-0.1	0.2
Medication: Seretide 50 evohaler	0.8	1.0	2.0	-1.2	-1.4	-0.4	-1.3	-0.7	-0.9	-0.6	1.4	-0.8	0.4
Mean time to correctly identify matches	1.9	3.7	10.8	-2.2	-1.6	0.2	3.1	0.9	1.2	1.2	-3.3	0.0	-2.3
Heart disease (mother)	0.4	0.4	3.3	-0.4	0.5	-0.3	-0.7	0.4	0.2	0.1	0.2	0.0	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.0	0.1	0.9	0.2	-0.5	0.2	0.4	0.4	0.4	0.8	-1.0
Whole body fat mass	1.1	4.5	18.3	-1.3	0.9	-2.4	2.7	-1.4	-0.8	-1.2	-4.3	-2.1	-1.6
Leg fat mass (right)	1.0	4.0	12.1	-1.0	1.7	-2.9	2.1	-1.6	-1.3	-1.5	-3.5	-2.2	-0.7
Arm predicted mass (right)	0.3	1.8	3.3	1.4	1.7	-1.1	0.5	-1.3	-0.7	-1.4	-1.2	-1.8	1.6
Pulse rate, automated reading	4.2	13.5	28.5	0.5	-0.9	-5.1	0.5	-5.3	-5.3	-5.3	-0.6	-4.6	-1.3
Alcohol intake frequency.	0.9	2.2	8.6	-1.0	0.3	0.4	-2.5	-0.1	-0.4	-0.2	2.1	0.9	2.9
Comparative height size at age 10	0.5	2.8	8.9	0.7	-0.9	-0.4	2.5	-1.4	0.5	-0.3	-3.0	-2.2	-1.9
Number of full sisters	2.2	2.7	10.9	1.1	-0.9	0.9	-3.1	0.8	0.4	0.7	3.3	1.5	-0.2
Suffer from ‘nerves’	0.2	0.4	0.9	0.2	-0.5	0.7	0.6	0.7	0.8	0.6	-1.0	-0.1	-0.0
Overall health rating	0.8	1.6	3.6	0.5	1.7	-1.9	-0.5	-1.6	-1.4	-1.3	0.5	-1.0	1.2
Chest pain or discomfort	1.1	1.6	3.7	-0.4	0.5	-1.9	-1.7	-1.3	-1.4	-1.1	1.0	-1.3	1.3
Had major operations	3.3	3.9	7.2	0.7	0.8	2.6	-1.2	2.7	2.4	2.4	1.7	2.5	1.0
Age at last live birth	0.5	0.7	1.4	0.5	1.2	-0.9	-0.1	-0.9	-1.0	-1.0	0.5	-0.7	0.7
Family relationship satisfaction	0.8	1.0	4.1	1.8	2.0	-0.1	1.1	0.1	0.5	0.3	-0.5	0.4	0.7
Leg pain on walking	2.0	2.5	7.2	2.4	2.7	-1.7	1.1	-1.8	-1.0	-1.5	-0.8	-0.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.1	1.7	1.8	-1.2	-0.9	-1.2	-1.7	-1.5	1.1	-0.4	1.0
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.6	1.1	0.1	1.2	-0.5	1.3	1.3	1.3	0.8	1.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-0.7	0.8	0.1	0.9	-0.1	-0.1	-0.1	-0.6	-0.1	0.6
Medication: Aspirin	1.2	1.6	4.5	-2.1	-0.9	-1.5	1.8	-0.4	-0.4	-0.8	-1.6	-1.4	-0.3
Supplements: Vitamin C	1.6	1.9	9.4	1.3	0.9	-0.4	3.1	0.1	0.6	-0.1	-2.5	-0.4	-0.7
Knee pain experienced in last month	0.5	0.8	3.6	1.9	1.3	-0.6	-0.8	-0.1	-0.2	-0.1	0.3	-0.1	-1.2
Hypertension (Self-reported)	0.4	1.2	2.5	-0.6	1.6	-1.0	1.5	0.0	1.0	0.9	-1.2	-0.3	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	2.0	0.6	-0.3	0.1	0.7	0.2	0.5	0.3	-0.4	0.0	-1.4
Illnesses of father: Heart disease	0.1	0.2	1.1	-0.0	0.5	-0.4	0.2	0.2	-0.1	-0.1	0.2	0.3	-1.1
Illnesses of siblings: Diabetes	0.4	0.4	1.0	-0.5	-0.3	-1.0	0.7	-0.9	-0.4	-0.5	-0.7	-0.6	-0.8
Smoking status: Previous	0.7	1.0	3.8	0.3	2.0	-1.0	1.2	-1.0	-0.3	-0.8	-1.0	-0.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.0	0.9	0.2	0.1	1.0	-0.6	0.1	-0.4	-1.4	-1.2	-0.2
Whole body fat-free mass	0.3	1.6	5.5	0.5	0.7	-0.8	1.3	-1.1	-0.5	-1.2	-2.3	-2.0	0.5
Leg fat-free mass (right)	0.2	1.2	7.5	-0.1	-0.4	0.1	1.6	-0.3	0.1	-0.4	-2.7	-1.2	-0.4
Arm fat percentage (left)	0.9	3.7	17.2	-2.0	0.2	-1.8	2.6	-0.5	-0.4	-0.4	-4.2	-1.3	-1.7
Average weekly red wine intake	0.2	0.3	1.1	0.1	0.2	0.5	0.0	0.3	1.1	0.6	-0.6	0.3	-0.3
Handedness (chirality/laterality): Left-handed	1.4	1.6	10.4	-0.2	-0.1	0.4	1.5	0.2	0.4	0.3	-1.7	0.0	-3.2
Mood swings	0.6	1.1	2.9	-0.6	-0.2	0.9	-1.3	1.2	0.4	0.8	0.9	1.7	1.5
Loneliness, isolation	1.2	1.6	5.8	-0.1	0.3	1.0	-2.4	1.0	0.3	0.7	1.9	1.5	1.4
Long-standing illness, disability or infirmity	1.4	2.1	8.4	1.7	2.0	-0.4	-1.4	-0.3	-0.2	-0.2	1.7	0.2	2.9
Ever had bowel cancer screening	0.9	1.0	2.3	-0.4	0.1	0.5	0.9	1.1	1.3	1.5	-1.3	0.7	-1.3
Diabetes diagnosed by doctor	1.4	2.3	10.5	0.2	0.0	-1.5	1.6	-0.9	-1.3	-1.1	-1.4	-1.5	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.1	1.1	2.0	-0.6	0.9	-0.9	-0.8	-1.3	0.1	-0.1	0.7
Friendships satisfaction	0.9	1.1	4.1	0.9	0.3	0.3	-1.9	0.4	-0.0	0.1	2.0	0.6	1.5
Qualifications: nursing, teaching	1.0	1.5	3.4	0.3	-0.8	-1.4	1.1	-1.0	-1.7	-1.5	-0.7	-1.8	-1.3
Commuting to job workplace: Walk	0.5	0.6	1.3	0.6	0.3	-0.9	-0.7	-0.9	-1.2	-1.0	0.1	-0.3	-0.5
Eye problems/disorders: Cataract	1.4	1.6	7.0	0.2	0.9	0.2	2.6	0.6	0.8	0.5	-2.0	0.4	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.5	1.3	1.6	-0.9	-0.0	-0.7	-1.2	-1.0	1.1	-0.3	1.1
Medication for cholesterol	0.5	0.7	2.3	-0.6	-1.3	1.5	-0.4	0.9	0.3	0.3	-0.1	1.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	0.6	-0.3	0.2	-0.4	0.6	0.0	0.1	0.4	0.2	-0.4
Back pain experienced in last month	0.3	0.4	2.1	-0.5	-1.5	-0.7	-0.2	0.2	0.8	0.4	-0.6	-0.2	-0.5
Mineral and other dietary supplements	1.1	1.5	4.5	-2.1	-1.1	-0.6	-1.7	-1.0	-1.8	-1.2	0.8	-0.5	0.1
Breast cancer (self-reported)	0.8	0.9	3.1	-0.9	0.8	-0.9	0.2	-1.3	-0.5	-0.6	0.2	-1.2	1.8
Asthma (self-reported)	2.1	4.2	18.7	-1.0	-2.6	0.6	-4.3	-0.0	-0.5	-0.2	3.6	-0.4	1.1
Osteoporosis (self-reported)	0.8	1.0	2.4	-1.5	-1.1	-1.5	0.0	-1.3	-0.7	-0.7	-0.3	-1.2	-0.1
Osteoarthritis (self-reported)	1.8	2.3	7.6	2.3	2.8	-0.9	-0.2	-1.5	-1.2	-1.4	0.3	-1.2	1.5
Medication: Aspirin	1.3	1.7	4.7	-2.2	-0.9	-1.6	1.5	-0.7	-0.7	-1.0	-1.3	-1.6	-0.3
Medication: Gliclazide	1.9	2.1	6.2	0.3	1.6	-1.1	2.3	-0.7	-0.5	-0.8	-1.9	-1.0	-2.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	0.9	0.1	0.5	-0.0	-0.3	0.0	-0.2	0.5	0.6	0.4
Smoking status: Current	1.1	1.7	4.7	1.7	1.8	-0.6	-0.7	-0.9	-0.1	-0.4	1.7	1.1	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.8	1.3	-0.0	-0.5	0.6	-0.1	-0.2	-0.6	-0.2	-0.8	-0.6
Whole body water mass	0.3	1.5	4.9	0.7	0.9	-0.7	1.2	-1.0	-0.5	-1.1	-2.2	-1.9	0.6
Leg predicted mass (right)	0.2	1.1	7.1	-0.1	-0.3	0.2	1.5	-0.2	0.2	-0.4	-2.7	-1.2	-0.4
Arm fat mass (left)	0.9	3.7	18.5	-1.2	0.7	-1.9	2.7	-0.8	-0.5	-0.8	-4.3	-1.7	-1.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.4	-0.3	0.4	-1.0	-1.2	0.1	-0.1	-0.0	0.5	-0.0	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	1.3	-0.2	1.1	-0.3	0.7	0.0	0.0	0.0	-0.2	-0.4	1.0
Miserableness	1.2	2.1	4.2	0.8	0.8	-1.4	-1.8	-1.5	-2.0	-1.5	1.4	-1.1	1.5
Guilty feelings	0.7	1.0	3.6	-1.9	-0.8	-0.0	-1.4	-0.2	-1.2	-0.7	0.7	-0.3	1.1
Wears glasses or contact lenses	1.0	1.2	2.8	1.6	0.3	0.4	1.6	0.6	0.5	0.4	-1.7	-0.4	-1.7
Ever taken oral contraceptive pill	0.9	1.1	2.1	-0.4	0.9	1.3	-1.1	1.1	0.8	0.9	0.7	1.5	1.1
Hearing aid user	0.6	0.7	2.7	-1.5	-0.9	0.7	-0.2	0.3	0.3	0.3	-0.1	0.9	-1.6
Mother’s age at death	1.4	1.8	9.1	0.0	-0.1	-0.4	2.6	0.2	0.7	0.7	-3.0	-0.5	-0.8
Financial situation satisfaction	0.3	0.4	1.4	0.2	-0.1	0.8	0.0	0.7	1.2	0.8	-0.5	0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.2	-0.5	-1.8	0.2	-1.6	0.2	0.3	0.2	1.5	-0.1	1.1
Commuting to job workplace: Public transport	0.4	0.5	2.3	-1.5	-0.1	-0.1	0.5	-0.2	-1.0	-0.7	-0.9	-0.4	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	1.1	1.1	-0.1	1.4	-0.3	-0.8	-0.7	-1.0	-0.8	-0.3
Medication: Blood pressure	0.9	1.7	3.6	0.2	1.7	-1.5	1.9	-1.1	-0.4	-0.2	-1.9	-1.5	-1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.7	-0.5	-0.6	-1.6	-1.6	-1.0	-0.9	-1.0	1.0	-0.9	0.7
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.8	1.3	-0.3	1.1	0.9	1.6	2.2	1.9	-0.6	0.6	-0.7
High cholesterol (Self-reported)	1.2	2.0	5.1	0.4	2.0	0.5	-1.1	1.3	1.3	1.2	1.9	1.1	2.3
Medication: Bendroflumethiazide	0.9	1.4	4.0	0.6	1.2	0.7	2.0	0.9	1.1	1.3	-1.2	0.7	-1.2
Medication: Paracetamol	0.6	0.9	2.1	-0.9	-0.6	1.1	0.6	1.0	1.4	1.1	-1.3	0.7	0.4
Medication: Lisinopril	0.7	0.9	3.3	0.8	0.4	-0.0	1.8	0.7	0.2	0.5	-1.4	-0.0	-1.5
Medication: Atorvastatin	1.0	1.2	3.6	0.7	0.7	1.4	-0.5	1.9	1.4	1.3	0.7	1.0	-0.1
Illnesses of father: High blood pressure	1.2	1.5	3.0	1.7	1.6	0.5	-0.8	1.1	1.7	1.6	0.8	1.0	0.6
Alcohol drinker status: Never	0.4	0.4	1.1	-0.6	-0.3	0.3	-1.0	0.1	-0.9	-0.4	0.9	-0.1	1.1
Ever smoked	0.3	0.6	2.1	-0.0	1.5	-0.7	1.2	-0.7	0.2	-0.1	-1.0	-0.1	0.2
Basal metabolic rate	0.3	1.7	7.2	0.3	0.8	-0.8	1.6	-1.0	-0.5	-1.1	-2.7	-1.9	0.3
Leg fat percentage (left)	1.0	3.7	10.4	-0.7	2.0	-2.9	2.1	-1.5	-1.1	-1.3	-3.2	-1.8	-0.6
Arm fat-free mass (left)	0.4	2.1	4.4	1.1	1.5	-1.4	1.1	-1.5	-1.0	-1.7	-1.9	-2.1	0.9
Number of operations (self-reported)	0.9	1.3	3.0	0.5	0.2	1.0	-0.6	1.4	1.2	1.4	1.7	1.6	1.0
Average weekly beer plus cider intake	0.5	0.7	2.0	-1.1	-1.4	0.8	-1.0	0.8	-0.3	-0.0	0.8	1.0	-0.5
Irritability	0.3	0.5	1.2	-0.7	-0.2	0.5	0.1	1.1	0.6	1.0	-0.9	0.8	0.5
Risk taking	1.1	1.7	5.9	0.7	-0.3	-0.3	-2.4	-0.5	-0.5	-0.7	2.4	0.2	1.8
Ever had prostate specific antigen (PSA) test	2.8	3.3	7.0	1.0	-0.3	2.1	-0.5	2.6	2.5	2.5	0.2	2.0	-1.7
Fractured/broken bones in last 5 years	0.6	0.7	2.9	-1.0	-0.6	-0.0	-1.7	0.6	0.5	0.5	0.6	1.3	-0.1
Age started oral contraceptive pill	1.9	2.3	6.2	0.4	0.9	-2.2	1.8	-1.9	-1.3	-1.5	-0.8	-2.5	0.0
Diastolic blood pressure, automated reading	1.0	3.0	6.0	0.5	-0.2	-2.5	-0.0	-2.0	-2.2	-2.1	-1.1	-2.3	-1.9
Ever depressed for a whole week	0.8	1.0	2.5	-0.6	1.1	-0.7	-1.6	-0.8	-1.2	-0.7	1.3	-0.5	1.0
Unable to work because of sickness or disability	2.9	3.7	10.2	1.0	1.4	-0.1	-3.1	-0.5	-1.5	-1.2	3.2	0.4	3.2
Commuting to job workplace: Cycle	0.6	0.7	1.3	-1.1	-0.2	-0.9	-0.1	-0.9	-1.1	-1.1	0.3	-0.9	0.9
Myopia	0.9	1.3	2.9	1.7	1.7	-0.9	-1.4	-0.9	-0.8	-0.6	1.1	-0.1	1.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.0	1.7	-1.1	1.1	-1.3	-0.0	-0.8	-0.8	1.3	0.2	0.8
Cholesterol lowering medication	0.4	0.5	2.4	-0.5	1.5	-1.4	-0.2	0.1	-0.2	-0.1	0.4	-0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.2	-0.8	-1.1	0.6	1.0	0.6	0.8	0.6	-1.0	0.4	-1.0
Pain experienced in last month	0.2	0.3	0.7	0.8	0.6	0.8	-0.5	0.1	-0.0	-0.0	0.8	0.1	0.8
Supplements: Calcium	1.6	1.8	5.3	2.3	1.6	0.5	-1.1	0.8	1.1	0.7	2.3	0.6	0.8
Basal cell carcinoma (self-reported)	1.1	1.3	3.0	-0.6	-0.1	-1.4	1.7	-1.5	-0.8	-0.8	-1.7	-0.9	-0.0
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.9	-0.9	1.2	0.8	-2.0	1.6	1.4	1.1	1.2	1.8	1.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	5.1	0.7	-0.3	-0.3	-0.9	0.4	1.4	0.6	0.6	-0.3	-2.3
Heart disease (siblings)	2.0	2.5	10.4	0.4	3.0	-1.7	-0.5	-0.8	-0.7	-0.5	0.6	-0.5	3.2
Alcohol drinker status: Previous	2.4	2.7	10.1	-0.8	-0.6	-1.3	-2.5	-1.6	-0.8	-1.2	3.2	-0.7	1.8
Pack years of smoking	1.6	2.3	12.0	0.2	0.6	-0.4	-2.0	-0.3	-0.2	-0.2	2.5	0.6	3.5
Impedance of whole body	0.3	1.7	4.2	-0.8	-1.9	1.4	-0.1	1.1	1.1	1.7	0.0	1.1	-2.1
Leg fat mass (left)	1.2	4.9	15.0	-1.1	1.4	-3.0	2.5	-1.8	-1.4	-1.7	-3.9	-2.4	-0.9
Arm predicted mass (left)	0.4	2.2	3.9	1.2	1.9	-1.3	1.1	-1.4	-0.8	-1.5	-1.9	-2.0	1.1