[Hub]/) : Traits : Lung FVC : ← →

chr16:68,901,284-73,789,190

Best TWAS P=9.22e-18 · Best GWAS P=5.31e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	COG4	0.19	0.23	enet	28	0.27	4.3e-33	-5.7	6.1	1.3e-09	0.32	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IL34	0.02	0.02	blup	149	0.01	4.1e-02	4.0	5.4	7.8e-08	0.06	0.04	0.52	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NOB1	0.04	0.05	enet	12	0.04	7.2e-06	-6.1	6.3	3.8e-10	0.61	0.85	0.13	FALSE
4	GTEx	Adipose Subcutaneous	NFAT5	0.09	0.02	enet	19	0.05	8.2e-05	-2.1	-6.6	3.4e-11	-0.53	0.08	0.62	TRUE
5	GTEx	Adipose Subcutaneous	IL34	0.04	0.00	enet	3	0.00	2.5e-01	4.2	-5.3	1.0e-07	-0.11	0.02	0.82	FALSE
6	GTEx	Artery Tibial	SF3B3	0.07	0.10	enet	17	0.08	4.9e-07	-5.9	6.1	1.4e-09	0.18	0.02	0.98	TRUE
7	GTEx	Brain Cerebellum	NOB1	0.15	0.08	lasso	3	0.07	3.7e-03	-6.2	5.3	1.3e-07	0.61	0.05	0.53	FALSE
8	GTEx	Brain Cerebellum	CTD-2033A16.3	0.14	0.15	lasso	4	0.12	2.2e-04	-6.0	5.6	2.7e-08	0.61	0.14	0.20	FALSE
9	GTEx	Breast Mammary Tissue (Female)	PDXDC2P	0.44	0.14	enet	16	0.16	1.9e-05	-3.1	-5.4	8.4e-08	-0.08	0.40	0.03	FALSE
10	GTEx	Cells Transformed fibroblasts	COG4	0.23	0.18	lasso	5	0.20	1.3e-14	-5.9	6.0	1.9e-09	0.26	0.02	0.98	FALSE
11	GTEx	Esophagus Mucosa	COG4	0.14	0.06	lasso	4	0.08	7.8e-06	-5.7	6.2	4.4e-10	0.26	0.05	0.94	FALSE
12	GTEx	Esophagus Mucosa	IL34	0.04	0.06	lasso	2	0.06	9.3e-05	-5.9	-6.0	2.5e-09	-0.19	0.02	0.97	FALSE
13	GTEx	Esophagus Mucosa	SF3B3	0.22	0.10	lasso	4	0.12	3.9e-08	-5.9	6.0	1.8e-09	0.17	0.02	0.98	FALSE
14	GTEx	Esophagus Mucosa	PDXDC2P	0.39	0.22	lasso	6	0.23	1.6e-15	-6.4	-5.6	2.4e-08	-0.28	1.00	0.00	FALSE
15	GTEx	Muscle Skeletal	COG4	0.05	0.08	lasso	1	0.07	9.4e-08	-5.8	5.8	8.2e-09	0.19	0.03	0.97	FALSE
16	GTEx	Nerve Tibial	IL34	0.07	0.07	lasso	3	0.06	4.1e-05	-5.8	-5.8	5.3e-09	-0.18	0.02	0.98	FALSE
17	GTEx	Skin Sun Exposed Lower leg	SF3B3	0.15	0.08	lasso	10	0.10	6.2e-09	-5.6	5.9	2.9e-09	0.06	0.04	0.96	TRUE
18	GTEx	Skin Sun Exposed Lower leg	PDXDC2P	0.34	0.22	enet	19	0.27	2.3e-22	3.2	-5.3	9.5e-08	-0.14	1.00	0.00	FALSE
19	GTEx	Testis	COG4	0.14	0.09	enet	11	0.11	9.4e-06	-5.9	-5.6	2.1e-08	-0.11	0.02	0.97	FALSE
20	GTEx	Testis	ZFHX3	0.28	0.10	lasso	5	0.11	1.8e-05	-5.2	-6.0	2.2e-09	-0.03	0.01	0.99	TRUE
21	GTEx	Testis	PDXDC2P	0.62	0.50	enet	15	0.57	6.8e-30	-6.4	-6.2	4.2e-10	-0.29	1.00	0.00	FALSE
22	GTEx	Testis	WWP2	0.30	0.10	lasso	5	0.16	9.2e-08	-5.6	-8.1	7.4e-16	-0.54	0.65	0.04	FALSE
23	GTEx	Thyroid	NOB1	0.03	0.01	enet	6	0.02	7.7e-03	-8.1	8.6	9.2e-18	0.77	0.11	0.64	TRUE
24	GTEx	Thyroid	SF3B3	0.07	0.00	enet	12	0.01	5.7e-02	2.7	5.6	2.0e-08	0.08	0.04	0.67	FALSE
25	GTEx	Thyroid	CTD-2033A16.3	0.03	0.02	enet	7	0.02	6.7e-03	-5.3	7.9	2.9e-15	0.69	0.13	0.55	FALSE
26	GTEx	Whole Blood	COG4	0.04	0.04	lasso	5	0.02	3.2e-03	-5.9	-5.4	5.6e-08	-0.11	0.02	0.97	FALSE
27	GTEx	Whole Blood	PDXDC2P	0.16	0.05	lasso	3	0.07	9.0e-07	-6.6	-6.2	6.3e-10	-0.22	0.94	0.00	FALSE
28	METSIM	Adipose	NOB1	0.03	0.03	lasso	2	0.03	2.8e-05	-6.1	7.5	6.4e-14	0.76	0.09	0.90	FALSE
29	METSIM	Adipose	WWP2	0.08	0.04	enet	19	0.07	2.7e-10	6.9	7.9	2.2e-15	0.74	0.49	0.51	FALSE
30	NTR	Blood	KIAA0174	0.06	0.02	bslmm	408	0.01	1.5e-05	-4.2	5.4	6.8e-08	0.02	0.30	0.63	TRUE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	COG4	0.03	0.04	blup	30	0.05	8.9e-05	-5.5	5.9	3.6e-09	0.18	0.02	0.96	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	NFAT5	0.02	0.01	enet	5	0.01	6.6e-04	-4.2	-7.7	1.1e-14	-0.64	0.03	0.46	TRUE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	NQO1	0.02	0.01	blup	39	0.01	4.3e-03	-5.7	-5.7	1.6e-08	-0.45	0.06	0.16	FALSE
34	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	COG4	0.13	0.06	blup	31	0.10	1.7e-05	-5.2	5.8	7.1e-09	0.21	0.03	0.96	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PDXDC2	0.20	0.02	blup	26	0.07	1.8e-04	4.2	6.0	2.1e-09	0.46	0.02	0.80	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	NQO1	0.06	0.04	lasso	3	0.01	5.3e-02	-5.7	-5.5	3.2e-08	-0.42	0.04	0.07	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	COG4	0.10	0.07	enet	7	0.08	1.9e-09	-5.8	5.7	1.3e-08	0.24	0.02	0.98	TRUE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL34	0.05	0.01	blup	46	0.01	2.3e-02	-4.9	-5.8	7.3e-09	-0.08	0.00	0.81	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	COG4	0.15	0.10	lasso	5	0.11	1.4e-12	-5.9	5.3	9.3e-08	0.19	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	COG4	0.10	0.07	blup	31	0.08	3.8e-05	-5.7	5.1	3.1e-07	0.16	0.02	0.96	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	COG4	0.08	0.08	lasso	3	0.09	1.0e-10	-5.2	6.0	2.3e-09	0.25	0.03	0.97	TRUE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	CLEC18C	0.06	0.02	lasso	2	0.02	6.6e-04	-6.1	5.9	3.0e-09	0.32	0.33	0.20	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	COG4	0.03	0.00	blup	30	0.01	9.7e-03	-5.7	5.8	9.1e-09	0.23	0.01	0.84	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	COG4	0.04	0.03	blup	30	0.03	5.0e-04	-5.5	5.7	1.5e-08	0.17	0.02	0.97	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	COG4	0.04	0.04	enet	4	0.04	5.6e-04	-5.7	5.8	7.5e-09	0.19	0.02	0.84	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PDXDC2	0.09	0.01	blup	26	0.06	4.7e-05	4.2	5.6	1.8e-08	0.47	0.12	0.16	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NOB1	0.13	0.01	blup	35	0.03	1.8e-02	-1.4	-5.6	2.0e-08	-0.55	0.01	0.31	FALSE
48	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	COG4	0.11	0.04	lasso	3	0.06	2.3e-03	-5.9	6.0	2.0e-09	0.25	0.01	0.96	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PHLPP2	0.11	0.02	lasso	4	0.01	9.4e-02	5.1	5.1	2.8e-07	0.02	0.01	0.56	FALSE
50	The Cancer Genome Atlas	Rectum Adenocarcinoma	CLEC18A	0.15	0.03	blup	23	0.09	4.3e-03	4.1	5.3	1.3e-07	0.63	0.01	0.21	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	PDXDC2	0.05	0.01	blup	26	0.03	9.5e-03	4.1	6.3	3.8e-10	0.55	0.01	0.72	FALSE
52	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CLEC18A	0.17	0.09	enet	8	0.11	8.5e-04	4.1	5.6	1.8e-08	0.63	0.05	0.14	FALSE
53	The Cancer Genome Atlas	Skin Cutaneous Melanoma	COG4	0.26	-0.01	blup	30	0.02	1.1e-01	-5.5	5.4	8.0e-08	0.25	0.01	0.58	TRUE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	COG4	0.06	0.08	blup	30	0.08	1.5e-06	-5.8	5.8	7.7e-09	0.17	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLEC18A	0.20	0.09	lasso	5	0.08	8.8e-04	6.9	7.0	3.2e-12	0.70	0.07	0.09	FALSE
56	The Cancer Genome Atlas	Testicular Germ Cell Tumors	COG4	0.11	0.08	blup	30	0.08	9.2e-04	-5.6	5.7	1.4e-08	0.13	0.02	0.86	FALSE