Hub : Genes

ZFHX3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.4000	0.0590	5.9e-10	0.283	NA	0.259	NA	0.287	2.0e-21	NA	1.7e-19	NA	9.5e-22
2	GTEx	Testis	0.2760	0.0730	2.1e-04	0.104	NA	0.099	NA	0.107	2.4e-05	NA	3.8e-05	NA	1.8e-05
3	YFS	Blood	0.0323	0.0133	5.4e-03	0.007	0.009	0.014	0.009	0.005	1.6e-03	0.00051	1.4e-05	0.00045	7.3e-03
4	TCGA	Brain Lower Grade Glioma	0.0667	0.0273	4.5e-03	0.012	0.020	0.011	NA	0.014	1.5e-02	0.00220	1.6e-02	NA	8.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	4.8	0.5	0.6	-2.2	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	2.0	0.6	0.4	-1.4	0.4
Depressed Affect (Nagel 2018)	1.3	2.7	6.4	2.5	0.8	-1.2	1.5
Depression (Nagel 2018)	2.6	3.9	6.7	2.4	0.4	-2.6	1.7
Intelligence (Savage-Jansen 2018)	1.9	5.7	10.8	-2.2	-2.2	1.6	-3.3
Neuroticism (Nagel 2018)	1.0	2.4	7.9	2.8	-0.2	-1.1	0.6
Schizophrenia (2018)	0.0	0.0	0.1	0.4	0.0	0.0	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-1.0	0.1	-0.5	-0.5
Worry (Nagel 2018)	0.9	2.0	2.5	1.6	-0.7	-1.6	-1.6
Alzheimer’s Disease (in mother)	4.0	4.6	12.5	-0.9	-1.0	3.5	-2.0
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.1	0.4	0.5	0.8
Alzheimer’s Disease (including proxy)	1.5	2.2	8.2	-0.2	-0.6	2.9	-0.2
Crohns Disease (2017)	0.2	0.4	1.2	-0.6	1.1	0.0	-0.5
Irritable Bowel Disease (IBD)	0.3	0.6	2.1	0.1	1.5	-0.3	-0.5
Ulcerative Colitis (UC)	0.4	0.7	2.2	0.7	1.5	-0.3	-0.0
Major Depression (MDD)	1.1	1.4	2.6	1.3	1.1	-0.2	1.6
Reaction Time	0.4	0.8	1.1	-1.1	-1.1	-0.7	-0.7
Verbal and Numeric Reasoning (VNR)	3.1	7.4	12.3	-2.3	-2.7	2.2	-3.5
Breast Cancer	1.4	3.3	8.8	-2.0	-3.0	-0.6	-0.1
Ovarian Cancer	0.1	0.1	0.3	-0.6	0.2	-0.0	-0.5
Prostate Cancer	1.0	1.4	4.2	-2.0	0.2	-0.4	1.2
Age at First Birth	0.4	0.6	2.2	-1.5	0.3	0.1	-0.3
Bipolar Disorder (2011)	0.4	0.4	1.4	1.2	0.3	0.1	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	2.6	0.8	1.1	-0.9	1.6
Coronary Artery Disease (CAD)	1.3	1.6	3.1	0.6	1.6	-1.8	-0.7
Crohns Disease (2012)	0.5	0.8	1.6	-0.1	1.1	-1.3	0.7
Mean Putamen Volume	0.9	1.0	3.6	-1.9	-0.2	-0.4	0.5
Fasting Glucose	1.0	1.2	2.1	-1.2	-1.4	1.2	-0.3
HbA1C	3.0	3.3	7.7	-2.8	0.4	2.3	-0.7
HDL Cholesterol	0.6	1.0	1.4	-1.1	-1.2	-0.2	-1.1
LDL Cholesterol	0.7	1.1	3.1	0.8	1.7	-0.0	-0.9
Lupus	1.8	2.7	4.6	-2.1	-1.0	-1.0	2.1
Neuroticism (2016)	1.5	2.2	7.0	2.6	0.1	0.8	-1.0
Primary Biliary Cirrhosis	0.6	0.9	1.4	-1.1	0.6	-1.2	-0.6
Rheumatoid Arthritis	0.3	0.4	1.4	0.4	0.4	-0.1	-1.2
Schizophrenia (2014)	0.1	0.3	0.8	-0.5	0.9	-0.1	0.2
Triglycerides	1.6	2.6	5.8	2.4	1.2	-1.7	0.5
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.5	1.1	1.4	-0.8	1.9
Ulcerative Colitis	0.4	0.6	1.0	0.5	-0.2	-1.0	-1.0
Blood Eosinophil Count	0.4	3.1	7.6	1.3	-1.6	-2.8	-0.8
Blood Platelet Count	0.6	6.4	12.4	0.8	-1.9	-3.5	3.0
Blood Red Count	0.3	3.0	6.1	2.0	2.5	0.4	-1.4
Blood White Count	0.1	0.6	2.1	1.5	-0.5	-0.0	-0.0
Heel T-Score	0.6	5.0	8.5	-2.6	1.1	1.9	-2.9
BMI	0.4	2.6	7.2	1.1	0.9	-1.0	2.7
Height	0.3	6.3	18.1	2.4	4.3	-0.3	1.1
Waist Hip Ratio (WHR)	1.3	5.7	9.1	3.0	2.3	-1.9	-2.1
Systolic Blood Pressure	0.1	0.3	0.4	-0.2	0.6	-0.5	-0.6
Smoking Status	4.2	10.0	24.7	3.8	-5.0	-0.9	0.1
Allergy or Eczema	2.5	6.5	18.4	-4.3	1.5	1.6	1.7
Cardiovascular Disease	0.1	0.4	1.1	-1.0	0.7	0.3	-0.1
Hypothyroidism (self reported)	0.9	2.1	4.1	-0.8	-2.0	0.4	1.8
Respiratory disease	0.2	0.5	0.9	-0.9	0.6	0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.2	1.4	0.6	-0.9	-1.8
Lung FEV1/FVC ratio	2.3	11.4	28.0	-2.0	5.3	-0.6	3.6
Lung FVC	2.4	12.1	35.8	0.3	-6.0	3.5	-0.4
Neuroticism	1.2	2.8	9.8	3.1	0.0	-1.1	0.2
Chronotype (morning person)	0.4	1.0	3.8	-0.2	1.9	-0.2	-0.3
Hair Pigment	0.1	2.3	5.0	0.2	1.6	-2.2	1.2
Tanning	0.2	2.6	8.3	0.8	-2.9	1.0	-0.7
Hand grip strength (left)	0.4	1.2	1.8	1.4	1.4	-0.4	0.9
Number of treatments/medications taken	1.7	3.1	7.2	-1.1	0.8	-2.7	-1.9
Average weekly spirits intake	1.6	1.9	4.5	-0.4	-1.6	0.7	-2.1
Sensitivity / hurt feelings	1.8	3.0	9.1	3.0	-1.1	1.2	-0.7
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.6	1.5	0.2	-1.1	1.6
Hearing difficulty/problems: Yes	2.5	3.8	7.9	-0.4	2.8	-0.8	2.5
Relative age of first facial hair	1.7	3.4	10.0	-1.7	3.2	-0.6	0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.1	-1.1	1.5	-0.5	1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.1	1.3	-0.1	-0.9	1.4
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	-0.2	-0.8	-0.6	0.7
Systolic blood pressure, automated reading	0.1	0.4	1.5	-0.5	1.2	-0.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.6	0.3	-0.1	-0.2
Angina	0.5	0.7	2.0	-0.4	0.1	-1.4	-0.7
Medication for hormone replacement therapy	0.4	0.5	1.9	-0.2	-0.2	-0.1	1.4
Vitamin and mineral supplements	1.2	1.6	6.3	0.5	0.0	2.5	0.2
Supplements: Zinc	0.5	0.5	1.2	-0.0	-0.9	-0.4	-1.1
Medication: Co-codamol	0.6	0.7	1.7	1.3	0.1	-1.0	0.2
Medication: Metformin	1.5	2.2	4.2	1.1	2.1	-1.3	-1.2
Diabetes (father)	2.7	3.4	11.2	0.3	3.3	-1.0	1.1
Diabetes (mother)	1.5	1.9	4.6	-0.8	2.1	-0.6	1.3
Severe depression (siblings)	0.6	0.7	1.6	0.4	1.0	-0.2	1.2
Pack years adult smoking proportion	0.8	1.2	3.8	-0.4	-2.0	-0.8	0.2
Impedance of leg (right)	0.7	3.4	11.4	0.7	-1.1	0.7	-3.4
Leg fat-free mass (left)	1.5	8.2	13.5	2.6	3.1	-1.7	3.7
Trunk fat percentage	0.8	3.2	7.8	1.4	2.8	-0.9	1.5
Hand grip strength (right)	0.9	2.3	4.2	1.8	1.0	-0.8	2.1
Townsend deprivation index at recruitment	0.8	1.1	3.2	1.0	-0.5	-0.3	1.8
Current tobacco smoking	3.1	5.1	15.6	2.1	-4.0	0.1	-0.7
Average weekly fortified wine intake	0.4	0.4	1.5	0.1	1.2	0.4	-0.2
Maternal smoking around birth	0.6	0.9	1.4	-1.2	-0.9	-0.4	1.1
Fed-up feelings	1.0	1.8	5.9	2.4	-0.3	-0.9	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.1	7.5	2.0	-0.2	-2.7	1.0
Relative age voice broke	0.9	1.3	2.0	-1.0	1.4	-1.2	1.0
Taking other prescription medications	1.0	1.5	3.7	-1.9	-0.7	-1.1	-0.7
Age when periods started (menarche)	0.4	0.9	1.5	0.5	1.2	-0.8	-1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	0.1	-0.1	-0.4	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	8.0	0.3	-1.1	1.5	-2.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.8	-0.5	-2.2	-0.4	-0.7
Qualifications: CSEs or equivalent	1.0	1.3	3.6	0.7	1.0	-1.9	0.2
Serious illness, injury or assault to yourself	0.7	0.9	2.0	-1.0	-0.0	-1.4	-0.7
High blood pressure	0.1	0.3	0.7	-0.5	0.8	0.1	0.6
Hayfever, allergic rhinitis or eczema	1.7	3.8	12.2	-3.5	1.2	-0.1	1.1
Multivitamins +/- minerals	0.9	1.1	2.1	-0.8	-0.7	-1.5	-1.1
Stomach or abdominal pain in last month	2.6	3.3	9.0	-0.2	1.7	-3.0	1.1
Supplements: Glucosamine	1.0	1.3	4.2	0.3	0.8	-2.1	0.2
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	6.0	0.9	2.5	-1.0	0.7
Medication: Atenolol	1.5	1.8	3.4	-0.2	1.8	-1.5	-1.3
Medication: Levothyroxine sodium	1.0	1.6	3.9	-0.9	-2.0	-0.5	1.3
Sitting height	0.9	6.4	13.0	2.8	3.6	-1.8	1.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	1.0	0.0	0.1	1.1
High blood pressure (mother)	1.6	2.3	4.9	0.3	1.7	-2.2	1.1
Body mass index (BMI)	0.7	2.8	5.6	1.0	1.7	-1.2	2.4
Impedance of leg (left)	0.7	3.3	12.4	0.3	-0.6	0.5	-3.5
Leg predicted mass (left)	1.5	8.1	13.2	2.5	3.2	-1.8	3.6
Trunk fat mass	1.4	5.8	10.5	2.2	3.2	-1.8	2.1
Waist circumference	1.2	4.6	6.2	2.5	2.4	-2.1	1.3
Number of incorrect matches in round	0.4	0.7	2.4	-0.2	-0.6	1.6	0.3
Past tobacco smoking	3.6	6.5	17.1	-3.0	4.1	0.0	0.1
Alcohol usually taken with meals	0.5	0.9	1.4	-1.2	1.2	-0.2	-0.7
Nervous feelings	0.6	1.1	2.4	0.8	-1.6	0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.7	0.9	-0.2	-0.9	1.3
Hearing difficulty/problems with background noise	1.9	3.0	8.2	-0.1	1.7	-1.0	2.9
Hair/balding pattern: Pattern 2	0.7	0.9	2.6	-1.6	0.9	-0.4	0.4
Had menopause	1.4	1.7	3.9	-1.3	-0.9	2.0	0.6
Had other major operations	0.4	0.4	0.9	-0.2	-0.9	0.1	0.9
Forced vital capacity (FVC)	0.4	1.6	5.5	2.4	-0.8	-0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	3.7	0.4	-0.4	0.4	-1.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.5	-0.3	-0.8	-1.4	2.1
Qualifications: None of the above	0.4	0.9	2.9	1.7	-0.7	-0.4	0.1
Financial difficulties in last 2 years	1.6	2.2	8.0	-0.6	-2.8	0.2	-0.7
Mouth/teeth dental problems	0.7	1.1	3.8	-1.9	0.8	0.4	-0.2
Heart attack	0.3	0.4	1.0	-0.1	0.1	-1.0	0.8
Allergy	1.0	2.2	8.4	2.9	-0.5	-0.2	-0.5
Pain all over the body in last month	0.2	0.3	0.8	0.3	0.1	0.4	0.9
Diabetes (self-reported)	2.6	4.1	6.0	1.3	2.5	-1.9	-2.2
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	8.4	-2.9	0.7	-1.1	0.0
Medication: Ramipril	1.8	2.3	4.5	-0.3	2.0	-0.8	-2.1
Medication: Simvastatin	2.2	3.2	5.9	-2.2	1.4	-0.2	-2.4
Fluid intelligence score	2.7	5.6	13.4	-0.6	-2.5	1.5	-3.7
Illnesses of siblings	0.6	0.9	2.9	-0.4	-1.7	-0.8	-0.1
Neuroticism score	0.6	1.3	4.4	2.1	-0.4	-0.6	-0.4
Weight	1.4	6.9	10.5	2.4	3.2	-1.9	2.8
Impedance of arm (right)	0.3	1.2	3.6	-0.2	0.1	1.1	-1.9
Arm fat percentage (right)	0.6	2.5	3.6	1.1	1.9	-1.5	1.7
Trunk fat-free mass	1.4	7.8	10.7	3.3	2.6	-2.3	2.9
Hip circumference	0.8	3.5	4.7	2.0	2.0	-1.2	2.2
Time employed in main current job	0.6	0.7	0.9	-0.9	0.8	-0.7	-0.9
Alcohol intake versus 10 years previously	0.9	1.3	2.5	-1.5	0.5	1.6	0.3
Father’s age at death	0.2	0.3	0.7	-0.6	-0.1	0.1	0.9
Worrier / anxious feelings	1.4	2.6	4.8	1.4	-1.8	-0.3	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.8	1.2	0.6	-1.9	0.6
Falls in the last year	0.5	0.7	2.1	0.3	0.7	1.5	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.2	0.0	0.5	0.3
Number of live births	0.1	0.1	0.3	-0.5	-0.5	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.8	1.3	0.5	-0.1	0.5
Pulse rate	0.2	0.4	0.8	-0.1	-0.5	0.7	-0.9
Happiness	2.9	3.5	11.1	0.9	1.4	-0.4	3.3
Noisy workplace	2.1	2.6	5.3	1.4	0.6	-2.3	1.6
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.7	-1.8	-0.8	0.2	-2.6
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.0	-2.8	-1.0	0.3	-0.6
Mouth/teeth dental problems: Dentures	0.7	1.1	3.5	1.9	0.1	-0.7	-0.7
Asthma	0.1	0.2	0.8	-0.9	0.1	0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.7	-1.0	-0.9	-0.7	1.3
Medication: Cholesterol lowering	1.0	1.6	3.5	-1.2	0.3	-1.1	-1.9
Depression (self-reported)	0.4	0.5	0.7	0.6	-0.6	-0.8	-0.6
Medication: Lansoprazole	0.4	0.4	0.7	0.3	-0.9	0.8	-0.3
Prospective memory result	0.2	0.3	1.1	-0.2	0.0	0.1	1.0
Lung cancer (father)	1.3	1.5	2.4	0.6	-1.3	1.4	-1.5
Illnesses of mother	0.8	1.0	2.9	0.4	-1.7	1.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.8	1.7	-0.0	-0.8	0.4
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	-0.3	0.4	-0.1	1.1
Impedance of arm (left)	0.4	2.0	4.3	-0.4	-0.0	2.1	-1.9
Arm fat mass (right)	1.1	4.7	6.8	1.8	2.6	-1.8	2.3
Trunk predicted mass	1.4	7.9	11.0	3.3	2.5	-2.3	3.0
Standing height	0.8	7.6	13.8	3.4	3.7	-1.9	1.4
Length of working week for main job	1.3	1.4	3.6	0.2	-1.9	-0.8	-1.1
Exposure to tobacco smoke at home	0.6	0.7	1.3	-0.5	0.5	-0.9	-1.2
Breastfed as a baby	0.6	0.7	1.3	1.0	-0.3	1.2	-0.6
Tense / ‘highly strung’	0.2	0.3	1.0	0.3	-0.1	0.1	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.2	1.0	-1.1	-0.9	1.1
Hair/balding pattern: Pattern 4	0.7	1.6	3.2	-1.8	-1.0	1.0	1.2
Birth weight of first child	2.0	3.6	8.6	2.9	2.2	-0.1	-1.0
Peak expiratory flow (PEF)	0.9	2.1	5.3	-1.0	2.3	0.6	1.3
Pulse wave reflection index	1.3	1.6	5.1	0.1	0.0	-1.2	2.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	0.0	0.9	-0.2	1.3
Loud music exposure frequency	2.6	2.9	9.4	0.3	-1.3	-0.6	3.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.5	-0.7	-0.7	1.2	-2.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.7	1.2	-0.9	1.9	0.2
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.5	-0.9	0.0	0.9
Medication: Paracetamol	0.2	0.3	0.6	-0.4	-0.4	0.3	-0.8
Headache pain in last month	0.1	0.2	0.6	0.1	0.3	-0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.6	1.1	-0.6	0.9	1.3
Glaucoma (self-reported)	0.4	0.4	1.1	0.6	1.1	0.4	-0.4
Gout (self-reported)	0.7	1.0	2.0	-1.4	-0.5	1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.3	-0.9	-1.9	-0.2	2.1
Medication: Amlodipine	0.9	1.3	4.2	0.6	0.8	0.2	2.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	-1.0	0.7	0.3	1.6
Birth weight	2.3	4.9	17.4	4.2	0.2	0.4	-1.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.4	1.2	0.2	-0.8	0.1
High blood pressure (siblings)	1.2	1.7	3.3	-0.3	1.8	1.5	1.0
Forced vital capacity (FVC), Best measure	0.5	1.8	4.5	2.1	-1.3	-1.0	-0.4
Body fat percentage	0.7	2.7	5.5	1.5	2.3	-1.2	1.4
Leg fat percentage (right)	0.7	2.4	4.9	2.2	1.2	-1.3	1.3
Arm fat-free mass (right)	1.2	6.2	8.3	2.7	2.5	-1.7	2.9
Exposure to tobacco smoke outside home	0.5	0.6	1.5	0.4	1.0	1.2	0.0
Comparative body size at age 10	1.2	3.4	6.9	2.1	-1.4	0.6	-2.6
Number of full brothers	1.6	2.0	3.0	1.4	0.2	-1.7	1.7
Worry too long after embarrassment	0.3	0.6	1.1	0.6	-1.1	0.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.1	-0.1	-1.4	-0.7	1.2
Wheeze or whistling in the chest in last year	0.9	1.6	2.5	-1.5	-0.3	-1.2	1.6
Number of children fathered	0.8	0.9	1.7	1.2	0.5	0.1	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.0	-1.0	-0.4	0.1	-0.1
Age at first live birth	0.7	1.3	2.5	-0.3	1.6	-1.2	-1.1
Pulse wave peak to peak time	0.3	0.3	0.9	0.6	-0.0	-0.2	-1.0
Health satisfaction	2.3	3.0	5.9	0.1	2.4	-2.0	1.5
Shortness of breath walking on level ground	1.1	1.3	3.8	-0.9	0.4	0.6	2.0
Qualifications: College or University degree	1.3	4.2	9.7	-3.1	-1.9	1.0	-1.5
Eye problems/disorders: None of the above	1.0	1.1	2.5	-0.3	-1.4	1.6	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.7	1.1	-1.3	0.4	0.2
Emphysema/chronic bronchitis	1.2	1.3	4.6	0.1	-0.4	2.1	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.6	1.2	0.7	1.1	0.9	-0.1
Neck or shoulder pain in last month	1.0	1.4	2.0	1.1	1.1	-1.1	1.4
Medication: Blood pressure	0.2	0.4	1.1	-0.3	-0.0	-0.4	-1.1
Angina (self-reported)	0.7	0.9	2.9	-0.0	0.1	-1.7	-0.8
Migraine (self-reported)	0.4	0.5	0.8	-0.8	-0.9	0.7	-0.3
Medication: Ibuprofen	0.7	0.8	1.5	-0.8	-0.3	-1.1	1.2
Medication: Allopurinol	0.9	1.2	4.2	-2.1	-0.5	-0.3	0.6
Medication: Omeprazole	0.2	0.3	0.4	0.6	0.6	-0.4	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	0.9	0.8	0.3	-0.9	-0.3
Mean time to correctly identify matches	0.5	0.9	1.6	-1.1	-1.3	0.1	-0.7
Heart disease (mother)	0.9	1.1	2.1	-1.4	1.4	-0.0	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	0.5	0.9	0.3	0.9
Whole body fat mass	1.4	5.6	9.1	2.3	3.0	-2.0	2.0
Leg fat mass (right)	1.4	5.4	6.6	2.6	2.5	-2.0	2.1
Arm predicted mass (right)	1.2	6.0	7.6	2.5	2.5	-2.0	2.8
Pulse rate, automated reading	0.5	1.5	5.3	0.1	-2.3	0.3	-0.7
Alcohol intake frequency.	1.0	2.3	8.8	0.1	3.0	0.2	0.5
Comparative height size at age 10	0.3	1.8	4.2	2.1	1.1	-1.1	0.5
Number of full sisters	2.2	2.7	3.7	1.9	-1.8	1.9	0.7
Suffer from ‘nerves’	0.4	0.7	1.5	0.8	0.4	-1.2	-0.7
Overall health rating	1.0	2.1	5.1	1.0	2.3	-1.1	1.0
Chest pain or discomfort	0.8	1.2	2.5	-0.9	0.5	-1.1	1.6
Had major operations	1.1	1.3	2.9	-0.5	-0.5	-1.7	1.4
Age at last live birth	0.7	1.0	2.9	-0.4	1.0	-1.7	0.3
Family relationship satisfaction	1.4	1.7	3.7	1.5	0.0	0.9	1.9
Leg pain on walking	0.3	0.4	1.0	0.6	1.0	-0.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.3	1.1	2.1	-0.8	0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.4	0.4	-1.2	-0.2	1.9
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.0	0.8	1.4	0.5	-0.9
Medication: Aspirin	0.3	0.3	0.6	-0.5	-0.8	-0.2	0.6
Supplements: Vitamin C	0.3	0.3	0.8	-0.3	0.2	-0.6	0.9
Knee pain experienced in last month	1.0	1.6	3.5	-0.8	1.3	1.9	0.7
Hypertension (Self-reported)	0.2	0.6	1.8	-0.2	1.3	0.4	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-0.6	1.0	1.2	0.1
Illnesses of father: Heart disease	0.8	1.0	1.8	0.1	0.9	-1.3	-1.3
Illnesses of siblings: Diabetes	2.5	3.1	4.9	1.8	2.2	-1.3	-1.6
Smoking status: Previous	2.0	3.0	7.6	2.0	-2.8	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	4.0	2.0	1.4	-1.9	1.4
Whole body fat-free mass	1.5	8.3	11.0	2.9	3.0	-2.2	3.3
Leg fat-free mass (right)	1.5	8.1	13.4	2.2	3.3	-1.8	3.7
Arm fat percentage (left)	0.5	2.1	3.1	1.2	1.7	-1.0	1.8
Average weekly red wine intake	0.5	0.8	1.2	-1.0	-0.7	-1.1	-0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.2	0.7	0.1	-2.1	-0.1
Mood swings	1.4	2.5	5.0	2.2	1.8	-1.0	0.7
Loneliness, isolation	1.4	1.9	3.1	-0.9	0.8	-1.8	1.7
Long-standing illness, disability or infirmity	1.2	1.9	3.2	-1.8	1.1	-1.7	0.4
Ever had bowel cancer screening	2.1	2.4	3.6	-1.7	-0.9	1.9	1.5
Diabetes diagnosed by doctor	2.7	4.5	7.0	1.6	2.6	-2.1	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.6	0.5	-1.6	-1.0	-0.6
Friendships satisfaction	1.2	1.4	5.3	-0.3	0.6	-0.2	2.3
Qualifications: nursing, teaching	0.9	1.5	3.5	-1.9	0.5	-1.3	-0.7
Commuting to job workplace: Walk	0.6	0.7	2.0	0.6	0.1	1.4	0.6
Eye problems/disorders: Cataract	1.4	1.6	4.1	1.6	0.2	-2.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	-0.8	0.3	-0.1	0.9
Medication for cholesterol	0.5	0.7	2.6	1.6	-0.3	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	-1.5	0.7	0.2	0.5
Back pain experienced in last month	1.0	1.5	3.0	-0.0	1.7	-1.4	1.0
Mineral and other dietary supplements	0.9	1.2	2.9	1.7	-0.9	1.0	0.4
Breast cancer (self-reported)	0.7	0.8	2.7	0.2	-1.6	0.4	0.5
Asthma (self-reported)	0.1	0.3	1.0	-1.0	0.5	0.1	0.1
Osteoporosis (self-reported)	1.3	1.6	2.9	-0.5	-1.6	-0.7	1.7
Osteoarthritis (self-reported)	1.5	2.0	4.9	-2.2	1.5	-0.2	0.9
Medication: Aspirin	0.2	0.2	0.6	-0.2	-0.8	-0.4	-0.1
Medication: Gliclazide	2.2	2.5	4.3	1.7	1.4	-2.1	-1.0
Illnesses of father: None of the above (group 1)	0.5	0.7	1.9	0.3	-0.1	1.4	0.8
Smoking status: Current	3.2	5.2	15.4	2.1	-3.9	-0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	7.7	-0.3	-0.7	2.8	0.9
Whole body water mass	1.4	8.1	11.2	2.8	2.9	-2.2	3.4
Leg predicted mass (right)	1.6	8.6	15.0	2.1	3.4	-1.8	3.9
Arm fat mass (left)	1.3	5.2	7.8	1.9	2.8	-1.8	2.5
Number of self-reported non-cancer illnesses	0.5	0.9	2.3	-1.5	0.8	-0.9	-0.2
Average weekly champagne plus white wine intake	0.5	0.7	2.0	0.2	-0.5	-0.6	-1.4
Miserableness	0.9	1.5	2.9	1.7	-1.4	-0.9	-0.6
Guilty feelings	1.2	1.9	3.3	1.8	-1.5	-0.2	1.4
Wears glasses or contact lenses	1.4	1.6	2.5	-0.6	-1.6	1.2	-1.4
Ever taken oral contraceptive pill	1.1	1.2	2.3	-1.5	-1.4	0.0	0.7
Hearing aid user	0.4	0.4	0.9	0.9	0.3	-0.8	0.4
Mother’s age at death	0.7	0.9	1.8	0.0	1.4	1.1	0.7
Financial situation satisfaction	0.7	0.8	2.4	-0.0	0.8	-0.4	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.2	-1.1	0.1	0.8	1.1
Commuting to job workplace: Public transport	0.8	1.0	2.9	-1.7	0.1	1.0	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.0	0.6	0.3	-0.6
Medication: Blood pressure	0.8	1.5	3.8	-0.6	2.0	-1.1	0.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.5	-1.5	1.6	0.9	0.7
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.0	-1.7	1.2	-1.1	-0.8
High cholesterol (Self-reported)	1.9	3.4	8.0	-2.2	0.6	-0.5	-2.8
Medication: Bendroflumethiazide	0.4	0.5	1.2	0.5	0.4	0.7	-1.1
Medication: Paracetamol	0.2	0.3	1.2	-0.1	0.2	-0.1	-1.1
Medication: Lisinopril	0.6	0.8	2.6	-0.5	1.6	-0.4	-0.6
Medication: Atorvastatin	0.7	0.9	2.6	0.3	-0.7	-1.6	-0.6
Illnesses of father: High blood pressure	0.7	0.9	1.7	-0.7	0.1	-1.3	-1.1
Alcohol drinker status: Never	0.3	0.4	0.7	0.2	0.8	0.6	0.7
Ever smoked	4.4	7.7	20.0	3.2	-4.5	0.1	-0.5
Basal metabolic rate	1.5	8.3	10.2	2.9	3.1	-2.2	3.2
Leg fat percentage (left)	0.7	2.6	4.1	2.0	1.6	-1.5	1.2
Arm fat-free mass (left)	1.4	7.2	8.8	2.5	2.7	-2.4	3.0
Number of operations (self-reported)	1.7	2.5	8.4	-0.7	-0.6	-0.9	2.9
Average weekly beer plus cider intake	0.6	0.8	3.0	1.7	-0.2	0.3	0.4
Irritability	1.0	1.7	5.9	2.4	0.4	-0.7	0.6
Risk taking	2.6	3.8	8.4	1.6	-2.0	0.5	2.9
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.4	-1.5	-0.5	-1.2	0.6
Fractured/broken bones in last 5 years	1.2	1.5	4.7	-0.5	-1.0	0.1	2.2
Age started oral contraceptive pill	1.2	1.5	2.9	-1.7	1.0	1.4	0.5
Diastolic blood pressure, automated reading	0.4	1.3	3.6	0.2	-0.5	-1.1	1.9
Ever depressed for a whole week	0.6	0.8	2.7	0.3	-0.6	-0.0	1.6
Unable to work because of sickness or disability	0.6	0.8	2.5	0.4	-0.7	1.6	-0.0
Commuting to job workplace: Cycle	1.4	1.7	3.9	1.4	-0.9	2.0	-0.0
Myopia	0.4	0.6	1.6	-0.1	-0.7	1.3	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	0.9	-0.4	-0.1	-0.4
Cholesterol lowering medication	0.9	1.3	3.3	-1.3	0.1	-0.5	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.7	-0.4	0.4	-0.8
Pain experienced in last month	2.2	3.7	11.5	0.4	-1.4	1.1	-3.4
Supplements: Calcium	0.7	0.8	1.6	0.6	-1.3	-0.5	-0.9
Basal cell carcinoma (self-reported)	1.3	1.6	4.0	0.2	2.0	-1.5	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.1	0.1	-1.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.9	0.6	-1.4	0.4	0.7
Heart disease (siblings)	0.9	1.1	1.8	1.3	1.0	1.2	-0.5
Alcohol drinker status: Previous	0.9	1.0	3.3	1.8	-0.5	0.3	0.7
Pack years of smoking	0.9	1.3	4.3	-0.7	-2.1	-0.7	-0.2
Impedance of whole body	0.5	2.6	8.8	-0.2	0.1	1.2	-3.0
Leg fat mass (left)	1.4	5.4	7.1	2.5	2.7	-2.1	1.9
Arm predicted mass (left)	1.3	6.7	8.0	2.5	2.6	-2.4	2.8