Hub : Genes

ZFHX3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.4000 0.0590 5.9e-10 0.283 NA 0.259 NA 0.287 2.0e-21 NA 1.7e-19 NA 9.5e-22
2 GTEx Testis 0.2760 0.0730 2.1e-04 0.104 NA 0.099 NA 0.107 2.4e-05 NA 3.8e-05 NA 1.8e-05
3 YFS Blood 0.0323 0.0133 5.4e-03 0.007 0.009 0.014 0.009 0.005 1.6e-03 0.00051 1.4e-05 0.00045 7.3e-03
4 TCGA Brain Lower Grade Glioma 0.0667 0.0273 4.5e-03 0.012 0.020 0.011 NA 0.014 1.5e-02 0.00220 1.6e-02 NA 8.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.9 1.4 4.8 0.5 0.6 -2.2 0.6
Bipolar Disorder or Schizophrenia 0.3 0.7 2.0 0.6 0.4 -1.4 0.4
Depressed Affect (Nagel 2018) 1.3 2.7 6.4 2.5 0.8 -1.2 1.5
Depression (Nagel 2018) 2.6 3.9 6.7 2.4 0.4 -2.6 1.7
Intelligence (Savage-Jansen 2018) 1.9 5.7 10.8 -2.2 -2.2 1.6 -3.3
Neuroticism (Nagel 2018) 1.0 2.4 7.9 2.8 -0.2 -1.1 0.6
Schizophrenia (2018) 0.0 0.0 0.1 0.4 0.0 0.0 0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 1.0 -1.0 0.1 -0.5 -0.5
Worry (Nagel 2018) 0.9 2.0 2.5 1.6 -0.7 -1.6 -1.6
Alzheimer’s Disease (in mother) 4.0 4.6 12.5 -0.9 -1.0 3.5 -2.0
Alzheimer’s Disease (in father) 0.3 0.3 0.6 -0.1 0.4 0.5 0.8
Alzheimer’s Disease (including proxy) 1.5 2.2 8.2 -0.2 -0.6 2.9 -0.2
Crohns Disease (2017) 0.2 0.4 1.2 -0.6 1.1 0.0 -0.5
Irritable Bowel Disease (IBD) 0.3 0.6 2.1 0.1 1.5 -0.3 -0.5
Ulcerative Colitis (UC) 0.4 0.7 2.2 0.7 1.5 -0.3 -0.0
Major Depression (MDD) 1.1 1.4 2.6 1.3 1.1 -0.2 1.6
Reaction Time 0.4 0.8 1.1 -1.1 -1.1 -0.7 -0.7
Verbal and Numeric Reasoning (VNR) 3.1 7.4 12.3 -2.3 -2.7 2.2 -3.5
Breast Cancer 1.4 3.3 8.8 -2.0 -3.0 -0.6 -0.1
Ovarian Cancer 0.1 0.1 0.3 -0.6 0.2 -0.0 -0.5
Prostate Cancer 1.0 1.4 4.2 -2.0 0.2 -0.4 1.2
Age at First Birth 0.4 0.6 2.2 -1.5 0.3 0.1 -0.3
Bipolar Disorder (2011) 0.4 0.4 1.4 1.2 0.3 0.1 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 2.6 0.8 1.1 -0.9 1.6
Coronary Artery Disease (CAD) 1.3 1.6 3.1 0.6 1.6 -1.8 -0.7
Crohns Disease (2012) 0.5 0.8 1.6 -0.1 1.1 -1.3 0.7
Mean Putamen Volume 0.9 1.0 3.6 -1.9 -0.2 -0.4 0.5
Fasting Glucose 1.0 1.2 2.1 -1.2 -1.4 1.2 -0.3
HbA1C 3.0 3.3 7.7 -2.8 0.4 2.3 -0.7
HDL Cholesterol 0.6 1.0 1.4 -1.1 -1.2 -0.2 -1.1
LDL Cholesterol 0.7 1.1 3.1 0.8 1.7 -0.0 -0.9
Lupus 1.8 2.7 4.6 -2.1 -1.0 -1.0 2.1
Neuroticism (2016) 1.5 2.2 7.0 2.6 0.1 0.8 -1.0
Primary Biliary Cirrhosis 0.6 0.9 1.4 -1.1 0.6 -1.2 -0.6
Rheumatoid Arthritis 0.3 0.4 1.4 0.4 0.4 -0.1 -1.2
Schizophrenia (2014) 0.1 0.3 0.8 -0.5 0.9 -0.1 0.2
Triglycerides 1.6 2.6 5.8 2.4 1.2 -1.7 0.5
Type 2 Diabetes (T2D) (2012) 1.6 1.8 3.5 1.1 1.4 -0.8 1.9
Ulcerative Colitis 0.4 0.6 1.0 0.5 -0.2 -1.0 -1.0
Blood Eosinophil Count 0.4 3.1 7.6 1.3 -1.6 -2.8 -0.8
Blood Platelet Count 0.6 6.4 12.4 0.8 -1.9 -3.5 3.0
Blood Red Count 0.3 3.0 6.1 2.0 2.5 0.4 -1.4
Blood White Count 0.1 0.6 2.1 1.5 -0.5 -0.0 -0.0
Heel T-Score 0.6 5.0 8.5 -2.6 1.1 1.9 -2.9
BMI 0.4 2.6 7.2 1.1 0.9 -1.0 2.7
Height 0.3 6.3 18.1 2.4 4.3 -0.3 1.1
Waist Hip Ratio (WHR) 1.3 5.7 9.1 3.0 2.3 -1.9 -2.1
Systolic Blood Pressure 0.1 0.3 0.4 -0.2 0.6 -0.5 -0.6
Smoking Status 4.2 10.0 24.7 3.8 -5.0 -0.9 0.1
Allergy or Eczema 2.5 6.5 18.4 -4.3 1.5 1.6 1.7
Cardiovascular Disease 0.1 0.4 1.1 -1.0 0.7 0.3 -0.1
Hypothyroidism (self reported) 0.9 2.1 4.1 -0.8 -2.0 0.4 1.8
Respiratory disease 0.2 0.5 0.9 -0.9 0.6 0.6 -0.7
Type 2 Diabetes (T2D) (2018) 0.8 1.6 3.2 1.4 0.6 -0.9 -1.8
Lung FEV1/FVC ratio 2.3 11.4 28.0 -2.0 5.3 -0.6 3.6
Lung FVC 2.4 12.1 35.8 0.3 -6.0 3.5 -0.4
Neuroticism 1.2 2.8 9.8 3.1 0.0 -1.1 0.2
Chronotype (morning person) 0.4 1.0 3.8 -0.2 1.9 -0.2 -0.3
Hair Pigment 0.1 2.3 5.0 0.2 1.6 -2.2 1.2
Tanning 0.2 2.6 8.3 0.8 -2.9 1.0 -0.7
Hand grip strength (left) 0.4 1.2 1.8 1.4 1.4 -0.4 0.9
Number of treatments/medications taken 1.7 3.1 7.2 -1.1 0.8 -2.7 -1.9
Average weekly spirits intake 1.6 1.9 4.5 -0.4 -1.6 0.7 -2.1
Sensitivity / hurt feelings 1.8 3.0 9.1 3.0 -1.1 1.2 -0.7
Frequency of depressed mood in last 2 weeks 1.1 1.5 2.6 1.5 0.2 -1.1 1.6
Hearing difficulty/problems: Yes 2.5 3.8 7.9 -0.4 2.8 -0.8 2.5
Relative age of first facial hair 1.7 3.4 10.0 -1.7 3.2 -0.6 0.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.1 -1.1 1.5 -0.5 1.1
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.1 1.3 -0.1 -0.9 1.4
Ever had hysterectomy (womb removed) 0.3 0.4 0.6 -0.2 -0.8 -0.6 0.7
Systolic blood pressure, automated reading 0.1 0.4 1.5 -0.5 1.2 -0.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 -0.6 0.3 -0.1 -0.2
Angina 0.5 0.7 2.0 -0.4 0.1 -1.4 -0.7
Medication for hormone replacement therapy 0.4 0.5 1.9 -0.2 -0.2 -0.1 1.4
Vitamin and mineral supplements 1.2 1.6 6.3 0.5 0.0 2.5 0.2
Supplements: Zinc 0.5 0.5 1.2 -0.0 -0.9 -0.4 -1.1
Medication: Co-codamol 0.6 0.7 1.7 1.3 0.1 -1.0 0.2
Medication: Metformin 1.5 2.2 4.2 1.1 2.1 -1.3 -1.2
Diabetes (father) 2.7 3.4 11.2 0.3 3.3 -1.0 1.1
Diabetes (mother) 1.5 1.9 4.6 -0.8 2.1 -0.6 1.3
Severe depression (siblings) 0.6 0.7 1.6 0.4 1.0 -0.2 1.2
Pack years adult smoking proportion 0.8 1.2 3.8 -0.4 -2.0 -0.8 0.2
Impedance of leg (right) 0.7 3.4 11.4 0.7 -1.1 0.7 -3.4
Leg fat-free mass (left) 1.5 8.2 13.5 2.6 3.1 -1.7 3.7
Trunk fat percentage 0.8 3.2 7.8 1.4 2.8 -0.9 1.5
Hand grip strength (right) 0.9 2.3 4.2 1.8 1.0 -0.8 2.1
Townsend deprivation index at recruitment 0.8 1.1 3.2 1.0 -0.5 -0.3 1.8
Current tobacco smoking 3.1 5.1 15.6 2.1 -4.0 0.1 -0.7
Average weekly fortified wine intake 0.4 0.4 1.5 0.1 1.2 0.4 -0.2
Maternal smoking around birth 0.6 0.9 1.4 -1.2 -0.9 -0.4 1.1
Fed-up feelings 1.0 1.8 5.9 2.4 -0.3 -0.9 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.1 7.5 2.0 -0.2 -2.7 1.0
Relative age voice broke 0.9 1.3 2.0 -1.0 1.4 -1.2 1.0
Taking other prescription medications 1.0 1.5 3.7 -1.9 -0.7 -1.1 -0.7
Age when periods started (menarche) 0.4 0.9 1.5 0.5 1.2 -0.8 -1.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.8 0.1 -0.1 -0.4 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 8.0 0.3 -1.1 1.5 -2.8
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 4.8 -0.5 -2.2 -0.4 -0.7
Qualifications: CSEs or equivalent 1.0 1.3 3.6 0.7 1.0 -1.9 0.2
Serious illness, injury or assault to yourself 0.7 0.9 2.0 -1.0 -0.0 -1.4 -0.7
High blood pressure 0.1 0.3 0.7 -0.5 0.8 0.1 0.6
Hayfever, allergic rhinitis or eczema 1.7 3.8 12.2 -3.5 1.2 -0.1 1.1
Multivitamins +/- minerals 0.9 1.1 2.1 -0.8 -0.7 -1.5 -1.1
Stomach or abdominal pain in last month 2.6 3.3 9.0 -0.2 1.7 -3.0 1.1
Supplements: Glucosamine 1.0 1.3 4.2 0.3 0.8 -2.1 0.2
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 6.0 0.9 2.5 -1.0 0.7
Medication: Atenolol 1.5 1.8 3.4 -0.2 1.8 -1.5 -1.3
Medication: Levothyroxine sodium 1.0 1.6 3.9 -0.9 -2.0 -0.5 1.3
Sitting height 0.9 6.4 13.0 2.8 3.6 -1.8 1.4
Chronic bronchitis/emphysema (father) 0.5 0.6 1.3 1.0 0.0 0.1 1.1
High blood pressure (mother) 1.6 2.3 4.9 0.3 1.7 -2.2 1.1
Body mass index (BMI) 0.7 2.8 5.6 1.0 1.7 -1.2 2.4
Impedance of leg (left) 0.7 3.3 12.4 0.3 -0.6 0.5 -3.5
Leg predicted mass (left) 1.5 8.1 13.2 2.5 3.2 -1.8 3.6
Trunk fat mass 1.4 5.8 10.5 2.2 3.2 -1.8 2.1
Waist circumference 1.2 4.6 6.2 2.5 2.4 -2.1 1.3
Number of incorrect matches in round 0.4 0.7 2.4 -0.2 -0.6 1.6 0.3
Past tobacco smoking 3.6 6.5 17.1 -3.0 4.1 0.0 0.1
Alcohol usually taken with meals 0.5 0.9 1.4 -1.2 1.2 -0.2 -0.7
Nervous feelings 0.6 1.1 2.4 0.8 -1.6 0.2 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.7 0.9 -0.2 -0.9 1.3
Hearing difficulty/problems with background noise 1.9 3.0 8.2 -0.1 1.7 -1.0 2.9
Hair/balding pattern: Pattern 2 0.7 0.9 2.6 -1.6 0.9 -0.4 0.4
Had menopause 1.4 1.7 3.9 -1.3 -0.9 2.0 0.6
Had other major operations 0.4 0.4 0.9 -0.2 -0.9 0.1 0.9
Forced vital capacity (FVC) 0.4 1.6 5.5 2.4 -0.8 -0.1 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 3.7 0.4 -0.4 0.4 -1.9
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.5 -0.3 -0.8 -1.4 2.1
Qualifications: None of the above 0.4 0.9 2.9 1.7 -0.7 -0.4 0.1
Financial difficulties in last 2 years 1.6 2.2 8.0 -0.6 -2.8 0.2 -0.7
Mouth/teeth dental problems 0.7 1.1 3.8 -1.9 0.8 0.4 -0.2
Heart attack 0.3 0.4 1.0 -0.1 0.1 -1.0 0.8
Allergy 1.0 2.2 8.4 2.9 -0.5 -0.2 -0.5
Pain all over the body in last month 0.2 0.3 0.8 0.3 0.1 0.4 0.9
Diabetes (self-reported) 2.6 4.1 6.0 1.3 2.5 -1.9 -2.2
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 8.4 -2.9 0.7 -1.1 0.0
Medication: Ramipril 1.8 2.3 4.5 -0.3 2.0 -0.8 -2.1
Medication: Simvastatin 2.2 3.2 5.9 -2.2 1.4 -0.2 -2.4
Fluid intelligence score 2.7 5.6 13.4 -0.6 -2.5 1.5 -3.7
Illnesses of siblings 0.6 0.9 2.9 -0.4 -1.7 -0.8 -0.1
Neuroticism score 0.6 1.3 4.4 2.1 -0.4 -0.6 -0.4
Weight 1.4 6.9 10.5 2.4 3.2 -1.9 2.8
Impedance of arm (right) 0.3 1.2 3.6 -0.2 0.1 1.1 -1.9
Arm fat percentage (right) 0.6 2.5 3.6 1.1 1.9 -1.5 1.7
Trunk fat-free mass 1.4 7.8 10.7 3.3 2.6 -2.3 2.9
Hip circumference 0.8 3.5 4.7 2.0 2.0 -1.2 2.2
Time employed in main current job 0.6 0.7 0.9 -0.9 0.8 -0.7 -0.9
Alcohol intake versus 10 years previously 0.9 1.3 2.5 -1.5 0.5 1.6 0.3
Father’s age at death 0.2 0.3 0.7 -0.6 -0.1 0.1 0.9
Worrier / anxious feelings 1.4 2.6 4.8 1.4 -1.8 -0.3 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.8 1.2 0.6 -1.9 0.6
Falls in the last year 0.5 0.7 2.1 0.3 0.7 1.5 0.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.2 0.0 0.5 0.3
Number of live births 0.1 0.1 0.3 -0.5 -0.5 0.1 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.8 1.3 0.5 -0.1 0.5
Pulse rate 0.2 0.4 0.8 -0.1 -0.5 0.7 -0.9
Happiness 2.9 3.5 11.1 0.9 1.4 -0.4 3.3
Noisy workplace 2.1 2.6 5.3 1.4 0.6 -2.3 1.6
Qualifications: A levels/AS levels or equivalent 1.2 2.7 6.7 -1.8 -0.8 0.2 -2.6
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 8.0 -2.8 -1.0 0.3 -0.6
Mouth/teeth dental problems: Dentures 0.7 1.1 3.5 1.9 0.1 -0.7 -0.7
Asthma 0.1 0.2 0.8 -0.9 0.1 0.2 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.7 -1.0 -0.9 -0.7 1.3
Medication: Cholesterol lowering 1.0 1.6 3.5 -1.2 0.3 -1.1 -1.9
Depression (self-reported) 0.4 0.5 0.7 0.6 -0.6 -0.8 -0.6
Medication: Lansoprazole 0.4 0.4 0.7 0.3 -0.9 0.8 -0.3
Prospective memory result 0.2 0.3 1.1 -0.2 0.0 0.1 1.0
Lung cancer (father) 1.3 1.5 2.4 0.6 -1.3 1.4 -1.5
Illnesses of mother 0.8 1.0 2.9 0.4 -1.7 1.0 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.8 1.7 -0.0 -0.8 0.4
Pulse wave Arterial Stiffness index 0.3 0.4 1.2 -0.3 0.4 -0.1 1.1
Impedance of arm (left) 0.4 2.0 4.3 -0.4 -0.0 2.1 -1.9
Arm fat mass (right) 1.1 4.7 6.8 1.8 2.6 -1.8 2.3
Trunk predicted mass 1.4 7.9 11.0 3.3 2.5 -2.3 3.0
Standing height 0.8 7.6 13.8 3.4 3.7 -1.9 1.4
Length of working week for main job 1.3 1.4 3.6 0.2 -1.9 -0.8 -1.1
Exposure to tobacco smoke at home 0.6 0.7 1.3 -0.5 0.5 -0.9 -1.2
Breastfed as a baby 0.6 0.7 1.3 1.0 -0.3 1.2 -0.6
Tense / ‘highly strung’ 0.2 0.3 1.0 0.3 -0.1 0.1 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.2 1.0 -1.1 -0.9 1.1
Hair/balding pattern: Pattern 4 0.7 1.6 3.2 -1.8 -1.0 1.0 1.2
Birth weight of first child 2.0 3.6 8.6 2.9 2.2 -0.1 -1.0
Peak expiratory flow (PEF) 0.9 2.1 5.3 -1.0 2.3 0.6 1.3
Pulse wave reflection index 1.3 1.6 5.1 0.1 0.0 -1.2 2.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.7 0.0 0.9 -0.2 1.3
Loud music exposure frequency 2.6 2.9 9.4 0.3 -1.3 -0.6 3.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.5 -0.7 -0.7 1.2 -2.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 3.7 1.2 -0.9 1.9 0.2
Blood clot in the leg (DVT) 0.4 0.5 0.9 0.5 -0.9 0.0 0.9
Medication: Paracetamol 0.2 0.3 0.6 -0.4 -0.4 0.3 -0.8
Headache pain in last month 0.1 0.2 0.6 0.1 0.3 -0.1 0.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.6 1.1 -0.6 0.9 1.3
Glaucoma (self-reported) 0.4 0.4 1.1 0.6 1.1 0.4 -0.4
Gout (self-reported) 0.7 1.0 2.0 -1.4 -0.5 1.3 -0.1
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 4.3 -0.9 -1.9 -0.2 2.1
Medication: Amlodipine 0.9 1.3 4.2 0.6 0.8 0.2 2.0
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.5 -1.0 0.7 0.3 1.6
Birth weight 2.3 4.9 17.4 4.2 0.2 0.4 -1.5
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.4 1.2 0.2 -0.8 0.1
High blood pressure (siblings) 1.2 1.7 3.3 -0.3 1.8 1.5 1.0
Forced vital capacity (FVC), Best measure 0.5 1.8 4.5 2.1 -1.3 -1.0 -0.4
Body fat percentage 0.7 2.7 5.5 1.5 2.3 -1.2 1.4
Leg fat percentage (right) 0.7 2.4 4.9 2.2 1.2 -1.3 1.3
Arm fat-free mass (right) 1.2 6.2 8.3 2.7 2.5 -1.7 2.9
Exposure to tobacco smoke outside home 0.5 0.6 1.5 0.4 1.0 1.2 0.0
Comparative body size at age 10 1.2 3.4 6.9 2.1 -1.4 0.6 -2.6
Number of full brothers 1.6 2.0 3.0 1.4 0.2 -1.7 1.7
Worry too long after embarrassment 0.3 0.6 1.1 0.6 -1.1 0.7 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.1 -0.1 -1.4 -0.7 1.2
Wheeze or whistling in the chest in last year 0.9 1.6 2.5 -1.5 -0.3 -1.2 1.6
Number of children fathered 0.8 0.9 1.7 1.2 0.5 0.1 1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.0 -1.0 -0.4 0.1 -0.1
Age at first live birth 0.7 1.3 2.5 -0.3 1.6 -1.2 -1.1
Pulse wave peak to peak time 0.3 0.3 0.9 0.6 -0.0 -0.2 -1.0
Health satisfaction 2.3 3.0 5.9 0.1 2.4 -2.0 1.5
Shortness of breath walking on level ground 1.1 1.3 3.8 -0.9 0.4 0.6 2.0
Qualifications: College or University degree 1.3 4.2 9.7 -3.1 -1.9 1.0 -1.5
Eye problems/disorders: None of the above 1.0 1.1 2.5 -0.3 -1.4 1.6 -0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.8 1.7 1.1 -1.3 0.4 0.2
Emphysema/chronic bronchitis 1.2 1.3 4.6 0.1 -0.4 2.1 -0.7
Medication for pain relief, constipation, heartburn 0.4 0.6 1.2 0.7 1.1 0.9 -0.1
Neck or shoulder pain in last month 1.0 1.4 2.0 1.1 1.1 -1.1 1.4
Medication: Blood pressure 0.2 0.4 1.1 -0.3 -0.0 -0.4 -1.1
Angina (self-reported) 0.7 0.9 2.9 -0.0 0.1 -1.7 -0.8
Migraine (self-reported) 0.4 0.5 0.8 -0.8 -0.9 0.7 -0.3
Medication: Ibuprofen 0.7 0.8 1.5 -0.8 -0.3 -1.1 1.2
Medication: Allopurinol 0.9 1.2 4.2 -2.1 -0.5 -0.3 0.6
Medication: Omeprazole 0.2 0.3 0.4 0.6 0.6 -0.4 -0.4
Medication: Seretide 50 evohaler 0.4 0.4 0.9 0.8 0.3 -0.9 -0.3
Mean time to correctly identify matches 0.5 0.9 1.6 -1.1 -1.3 0.1 -0.7
Heart disease (mother) 0.9 1.1 2.1 -1.4 1.4 -0.0 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.8 0.5 0.9 0.3 0.9
Whole body fat mass 1.4 5.6 9.1 2.3 3.0 -2.0 2.0
Leg fat mass (right) 1.4 5.4 6.6 2.6 2.5 -2.0 2.1
Arm predicted mass (right) 1.2 6.0 7.6 2.5 2.5 -2.0 2.8
Pulse rate, automated reading 0.5 1.5 5.3 0.1 -2.3 0.3 -0.7
Alcohol intake frequency. 1.0 2.3 8.8 0.1 3.0 0.2 0.5
Comparative height size at age 10 0.3 1.8 4.2 2.1 1.1 -1.1 0.5
Number of full sisters 2.2 2.7 3.7 1.9 -1.8 1.9 0.7
Suffer from ‘nerves’ 0.4 0.7 1.5 0.8 0.4 -1.2 -0.7
Overall health rating 1.0 2.1 5.1 1.0 2.3 -1.1 1.0
Chest pain or discomfort 0.8 1.2 2.5 -0.9 0.5 -1.1 1.6
Had major operations 1.1 1.3 2.9 -0.5 -0.5 -1.7 1.4
Age at last live birth 0.7 1.0 2.9 -0.4 1.0 -1.7 0.3
Family relationship satisfaction 1.4 1.7 3.7 1.5 0.0 0.9 1.9
Leg pain on walking 0.3 0.4 1.0 0.6 1.0 -0.1 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 4.3 1.1 2.1 -0.8 0.9
Commuting to job workplace: Car/motor vehicle 1.1 1.3 3.4 0.4 -1.2 -0.2 1.9
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.0 0.8 1.4 0.5 -0.9
Medication: Aspirin 0.3 0.3 0.6 -0.5 -0.8 -0.2 0.6
Supplements: Vitamin C 0.3 0.3 0.8 -0.3 0.2 -0.6 0.9
Knee pain experienced in last month 1.0 1.6 3.5 -0.8 1.3 1.9 0.7
Hypertension (Self-reported) 0.2 0.6 1.8 -0.2 1.3 0.4 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.5 -0.6 1.0 1.2 0.1
Illnesses of father: Heart disease 0.8 1.0 1.8 0.1 0.9 -1.3 -1.3
Illnesses of siblings: Diabetes 2.5 3.1 4.9 1.8 2.2 -1.3 -1.6
Smoking status: Previous 2.0 3.0 7.6 2.0 -2.8 0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 4.0 2.0 1.4 -1.9 1.4
Whole body fat-free mass 1.5 8.3 11.0 2.9 3.0 -2.2 3.3
Leg fat-free mass (right) 1.5 8.1 13.4 2.2 3.3 -1.8 3.7
Arm fat percentage (left) 0.5 2.1 3.1 1.2 1.7 -1.0 1.8
Average weekly red wine intake 0.5 0.8 1.2 -1.0 -0.7 -1.1 -0.6
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.2 0.7 0.1 -2.1 -0.1
Mood swings 1.4 2.5 5.0 2.2 1.8 -1.0 0.7
Loneliness, isolation 1.4 1.9 3.1 -0.9 0.8 -1.8 1.7
Long-standing illness, disability or infirmity 1.2 1.9 3.2 -1.8 1.1 -1.7 0.4
Ever had bowel cancer screening 2.1 2.4 3.6 -1.7 -0.9 1.9 1.5
Diabetes diagnosed by doctor 2.7 4.5 7.0 1.6 2.6 -2.1 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.6 0.5 -1.6 -1.0 -0.6
Friendships satisfaction 1.2 1.4 5.3 -0.3 0.6 -0.2 2.3
Qualifications: nursing, teaching 0.9 1.5 3.5 -1.9 0.5 -1.3 -0.7
Commuting to job workplace: Walk 0.6 0.7 2.0 0.6 0.1 1.4 0.6
Eye problems/disorders: Cataract 1.4 1.6 4.1 1.6 0.2 -2.0 0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.9 -0.8 0.3 -0.1 0.9
Medication for cholesterol 0.5 0.7 2.6 1.6 -0.3 0.2 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.2 -1.5 0.7 0.2 0.5
Back pain experienced in last month 1.0 1.5 3.0 -0.0 1.7 -1.4 1.0
Mineral and other dietary supplements 0.9 1.2 2.9 1.7 -0.9 1.0 0.4
Breast cancer (self-reported) 0.7 0.8 2.7 0.2 -1.6 0.4 0.5
Asthma (self-reported) 0.1 0.3 1.0 -1.0 0.5 0.1 0.1
Osteoporosis (self-reported) 1.3 1.6 2.9 -0.5 -1.6 -0.7 1.7
Osteoarthritis (self-reported) 1.5 2.0 4.9 -2.2 1.5 -0.2 0.9
Medication: Aspirin 0.2 0.2 0.6 -0.2 -0.8 -0.4 -0.1
Medication: Gliclazide 2.2 2.5 4.3 1.7 1.4 -2.1 -1.0
Illnesses of father: None of the above (group 1) 0.5 0.7 1.9 0.3 -0.1 1.4 0.8
Smoking status: Current 3.2 5.2 15.4 2.1 -3.9 -0.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 7.7 -0.3 -0.7 2.8 0.9
Whole body water mass 1.4 8.1 11.2 2.8 2.9 -2.2 3.4
Leg predicted mass (right) 1.6 8.6 15.0 2.1 3.4 -1.8 3.9
Arm fat mass (left) 1.3 5.2 7.8 1.9 2.8 -1.8 2.5
Number of self-reported non-cancer illnesses 0.5 0.9 2.3 -1.5 0.8 -0.9 -0.2
Average weekly champagne plus white wine intake 0.5 0.7 2.0 0.2 -0.5 -0.6 -1.4
Miserableness 0.9 1.5 2.9 1.7 -1.4 -0.9 -0.6
Guilty feelings 1.2 1.9 3.3 1.8 -1.5 -0.2 1.4
Wears glasses or contact lenses 1.4 1.6 2.5 -0.6 -1.6 1.2 -1.4
Ever taken oral contraceptive pill 1.1 1.2 2.3 -1.5 -1.4 0.0 0.7
Hearing aid user 0.4 0.4 0.9 0.9 0.3 -0.8 0.4
Mother’s age at death 0.7 0.9 1.8 0.0 1.4 1.1 0.7
Financial situation satisfaction 0.7 0.8 2.4 -0.0 0.8 -0.4 1.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.2 -1.1 0.1 0.8 1.1
Commuting to job workplace: Public transport 0.8 1.0 2.9 -1.7 0.1 1.0 -0.1
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 -0.0 0.6 0.3 -0.6
Medication: Blood pressure 0.8 1.5 3.8 -0.6 2.0 -1.1 0.7
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.5 -1.5 1.6 0.9 0.7
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.0 -1.7 1.2 -1.1 -0.8
High cholesterol (Self-reported) 1.9 3.4 8.0 -2.2 0.6 -0.5 -2.8
Medication: Bendroflumethiazide 0.4 0.5 1.2 0.5 0.4 0.7 -1.1
Medication: Paracetamol 0.2 0.3 1.2 -0.1 0.2 -0.1 -1.1
Medication: Lisinopril 0.6 0.8 2.6 -0.5 1.6 -0.4 -0.6
Medication: Atorvastatin 0.7 0.9 2.6 0.3 -0.7 -1.6 -0.6
Illnesses of father: High blood pressure 0.7 0.9 1.7 -0.7 0.1 -1.3 -1.1
Alcohol drinker status: Never 0.3 0.4 0.7 0.2 0.8 0.6 0.7
Ever smoked 4.4 7.7 20.0 3.2 -4.5 0.1 -0.5
Basal metabolic rate 1.5 8.3 10.2 2.9 3.1 -2.2 3.2
Leg fat percentage (left) 0.7 2.6 4.1 2.0 1.6 -1.5 1.2
Arm fat-free mass (left) 1.4 7.2 8.8 2.5 2.7 -2.4 3.0
Number of operations (self-reported) 1.7 2.5 8.4 -0.7 -0.6 -0.9 2.9
Average weekly beer plus cider intake 0.6 0.8 3.0 1.7 -0.2 0.3 0.4
Irritability 1.0 1.7 5.9 2.4 0.4 -0.7 0.6
Risk taking 2.6 3.8 8.4 1.6 -2.0 0.5 2.9
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.4 -1.5 -0.5 -1.2 0.6
Fractured/broken bones in last 5 years 1.2 1.5 4.7 -0.5 -1.0 0.1 2.2
Age started oral contraceptive pill 1.2 1.5 2.9 -1.7 1.0 1.4 0.5
Diastolic blood pressure, automated reading 0.4 1.3 3.6 0.2 -0.5 -1.1 1.9
Ever depressed for a whole week 0.6 0.8 2.7 0.3 -0.6 -0.0 1.6
Unable to work because of sickness or disability 0.6 0.8 2.5 0.4 -0.7 1.6 -0.0
Commuting to job workplace: Cycle 1.4 1.7 3.9 1.4 -0.9 2.0 -0.0
Myopia 0.4 0.6 1.6 -0.1 -0.7 1.3 0.4
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.8 0.9 -0.4 -0.1 -0.4
Cholesterol lowering medication 0.9 1.3 3.3 -1.3 0.1 -0.5 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.6 0.7 -0.4 0.4 -0.8
Pain experienced in last month 2.2 3.7 11.5 0.4 -1.4 1.1 -3.4
Supplements: Calcium 0.7 0.8 1.6 0.6 -1.3 -0.5 -0.9
Basal cell carcinoma (self-reported) 1.3 1.6 4.0 0.2 2.0 -1.5 -0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.1 0.1 0.1 -1.1 0.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.9 0.6 -1.4 0.4 0.7
Heart disease (siblings) 0.9 1.1 1.8 1.3 1.0 1.2 -0.5
Alcohol drinker status: Previous 0.9 1.0 3.3 1.8 -0.5 0.3 0.7
Pack years of smoking 0.9 1.3 4.3 -0.7 -2.1 -0.7 -0.2
Impedance of whole body 0.5 2.6 8.8 -0.2 0.1 1.2 -3.0
Leg fat mass (left) 1.4 5.4 7.1 2.5 2.7 -2.1 1.9
Arm predicted mass (left) 1.3 6.7 8.0 2.5 2.6 -2.4 2.8