[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr16:66,666,637-69,084,178

Best TWAS P=2.26e-10 · Best GWAS P=3.77e-11 conditioned to 0.0645

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Thyroid	HSD11B2	0.15	0.07	enet	23	0.09	1.9e-07	5.2	6.3	2.3e-10	0.89	0.14	0.86	TRUE
10	GTEx	Nerve Tibial	LCAT	0.08	0.06	lasso	4	0.04	8.4e-04	5.3	5.8	7.1e-09	0.35	0.74	0.15	TRUE
25	YFS	Blood	ATP6V0D1	0.14	0.18	lasso	15	0.20	1.8e-63	6.5	-6.3	2.5e-10	-0.93	0.02	0.98	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	CTCF	0.11	0.03	lasso	5	0.04	2.4e-02	5.3	6.3	2.8e-10	0.74	0.07	0.45	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TPPP3	0.03	0.02	blup	31	0.04	2.1e-05	6.1	-6.2	4.9e-10	-0.92	0.03	0.96	FALSE
27	YFS	Blood	ZDHHC1	0.05	0.05	enet	26	0.05	1.8e-16	6.4	6.2	5.6e-10	0.88	0.01	0.99	FALSE
7	GTEx	Esophagus Muscularis	RANBP10	0.13	0.05	lasso	4	0.02	2.3e-02	6.2	-6.2	6.3e-10	-0.90	0.11	0.83	FALSE
15	GTEx	Spleen	ATP6V0D1	0.36	0.03	enet	9	0.07	6.0e-03	4.1	-6.2	6.6e-10	-0.85	0.02	0.51	FALSE
26	YFS	Blood	DUS2L	0.19	0.23	enet	28	0.28	3.8e-91	5.1	6.2	7.1e-10	0.61	0.77	0.23	FALSE
4	GTEx	Artery Tibial	RANBP10	0.08	0.04	lasso	3	0.05	6.4e-05	6.1	-6.1	8.8e-10	-0.93	0.20	0.77	FALSE
21	GTEx	Whole Blood	DUS2	0.12	0.04	enet	10	0.05	4.0e-05	5.2	6.1	9.6e-10	0.76	0.69	0.30	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	ZDHHC1	0.07	0.06	enet	7	0.07	2.9e-07	6.2	6.1	9.8e-10	0.96	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	AGRP	0.04	0.02	blup	23	0.03	3.0e-03	6.2	6.0	1.5e-09	0.90	0.00	0.76	FALSE
9	GTEx	Nerve Tibial	RANBP10	0.15	0.14	lasso	7	0.13	1.8e-09	5.6	-6.0	1.7e-09	-0.88	0.48	0.52	FALSE
17	GTEx	Thyroid	ZDHHC1	0.07	0.03	lasso	6	0.02	1.6e-02	6.0	6.0	1.7e-09	0.95	0.11	0.69	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	CTRL	0.13	0.04	lasso	9	0.08	2.7e-05	5.2	6.0	2.2e-09	0.69	0.64	0.22	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC36	0.07	0.03	blup	39	0.03	2.5e-04	6.4	6.0	2.2e-09	0.88	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZDHHC1	0.02	0.01	lasso	1	0.01	2.4e-03	5.9	-5.9	2.7e-09	-0.94	0.04	0.52	FALSE
41	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRC36	0.13	0.12	lasso	14	0.11	1.4e-03	5.9	5.9	2.8e-09	0.93	0.01	0.66	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	LRRC36	0.04	0.04	lasso	3	0.04	1.5e-04	5.9	5.9	2.8e-09	0.94	0.05	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP6V0D1	0.10	0.12	lasso	8	0.11	2.4e-13	5.2	-5.9	3.0e-09	-0.85	0.16	0.84	FALSE
22	METSIM	Adipose	LRRC36	0.10	0.07	lasso	24	0.10	1.6e-14	5.9	5.9	3.3e-09	0.93	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP6V0D1	0.04	0.02	blup	33	0.03	4.7e-04	5.2	-5.9	3.8e-09	-0.89	0.03	0.95	FALSE
20	GTEx	Whole Blood	ATP6V0D1	0.08	0.00	enet	13	0.00	3.6e-01	5.1	-5.9	4.3e-09	-0.86	0.02	0.90	FALSE
16	GTEx	Thyroid	RANBP10	0.08	0.03	lasso	4	0.03	2.2e-03	5.3	-5.8	6.3e-09	-0.89	0.19	0.34	FALSE
14	GTEx	Skin Sun Exposed Lower leg	LCAT	0.07	0.06	lasso	6	0.05	4.1e-05	5.2	5.8	6.5e-09	0.42	0.89	0.11	FALSE
5	GTEx	Artery Tibial	LCAT	0.04	0.06	enet	9	0.04	1.9e-04	5.3	5.8	7.7e-09	0.37	0.60	0.16	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	CENPT	0.02	0.01	blup	33	0.01	6.9e-02	5.2	5.7	9.6e-09	0.74	0.01	0.79	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TSNAXIP1	0.02	0.03	blup	225	0.01	6.2e-03	4.0	5.7	1.0e-08	0.58	0.29	0.38	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	RANBP10	0.04	0.03	blup	31	0.04	6.5e-05	5.1	-5.7	1.0e-08	-0.77	0.02	0.96	FALSE
23	NTR	Blood	ATP6V0D1	0.02	0.01	bslmm	220	0.01	1.6e-04	5.2	-5.7	1.3e-08	-0.75	0.08	0.85	FALSE
24	NTR	Blood	DUS2L	0.01	0.01	bslmm	263	0.01	3.6e-03	5.2	5.6	2.4e-08	0.49	0.10	0.84	FALSE
3	GTEx	Adipose Subcutaneous	RANBP10	0.05	0.01	lasso	6	0.01	3.5e-02	5.2	-5.5	2.9e-08	-0.83	0.23	0.63	FALSE
19	GTEx	Vagina	PRMT7	0.26	0.17	enet	14	0.23	5.6e-06	2.6	5.4	7.0e-08	0.29	0.20	0.39	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ATP6V0D1	0.04	0.06	lasso	4	0.05	1.4e-06	5.1	-5.4	7.1e-08	-0.76	0.24	0.75	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf86	0.05	0.05	lasso	1	0.04	2.9e-05	5.3	-5.3	9.2e-08	-0.81	0.00	0.99	FALSE
8	GTEx	Muscle Skeletal	C16orf86	0.05	0.04	lasso	2	0.03	4.0e-04	5.2	-5.3	1.0e-07	-0.82	0.14	0.43	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GFOD2	0.03	0.03	lasso	1	0.03	3.6e-04	5.3	-5.3	1.2e-07	-0.77	0.01	0.98	FALSE
11	GTEx	Pituitary	ZDHHC1	0.23	0.13	lasso	4	0.08	4.0e-03	5.2	5.2	1.8e-07	0.75	0.05	0.36	FALSE
13	GTEx	Skin Sun Exposed Lower leg	SLC12A4	0.04	0.03	lasso	3	0.03	3.1e-03	5.2	5.2	2.0e-07	0.32	0.62	0.12	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf86	0.04	0.04	lasso	2	0.03	3.8e-04	5.3	-5.2	2.3e-07	-0.81	0.00	0.98	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	CENPT	0.05	0.05	enet	8	0.04	3.0e-03	5.2	5.1	2.7e-07	0.73	0.01	0.90	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DUS2L	0.07	0.04	lasso	2	0.03	6.4e-04	5.3	5.1	2.7e-07	0.30	0.00	0.99	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TSNAXIP1	0.10	0.09	blup	32	0.08	3.9e-04	4.0	5.1	3.1e-07	0.56	0.08	0.49	FALSE