TWAS hub - LRRC10B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.657	0.068	1.9e-05	0.031	NA	0.086	NA	0.027	0.019	NA	0.00018	NA	0.02600
2	GTEx	Spleen	0.345	0.114	9.8e-03	0.053	NA	0.058	NA	0.059	0.018	NA	0.01400	NA	0.01300
3	TCGA	Testicular Germ Cell Tumors	0.245	0.120	1.5e-03	0.019	0.085	0.091	NA	0.097	0.069	0.00064	0.00042	NA	0.00027

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Headache pain in last month	4.5	7.7	18.2	4.3	2.2
LDL Cholesterol	3.9	6.2	17.2	1.1	-4.1
Emphysema/chronic bronchitis	3.1	3.5	10.6	3.3	0.1
Neuroticism	2.8	6.8	14.5	-3.8	2.4
Irritable Bowel Disease (IBD)	2.7	6.5	10.0	-3.1	3.2
Exposure to tobacco smoke at home	2.5	2.8	7.9	0.6	2.8
Family relationship satisfaction	2.4	2.9	5.9	-2.4	1.7
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	4.4	-2.0	-2.1
Crohns Disease (2017)	2.2	4.9	10.0	-3.2	2.2
Tense / ‘highly strung’	2.1	3.4	9.0	-3.0	1.1
Age started oral contraceptive pill	2.1	2.7	5.5	-2.3	-1.6
Neuroticism (2016)	2.0	2.9	8.5	-2.9	-0.4
Heart disease (mother)	2.0	2.4	5.2	-2.3	1.4
Neuroticism (Nagel 2018)	1.9	4.5	13.2	-3.6	0.6
Neuroticism score	1.9	4.0	8.6	-2.9	1.9
Happiness	1.9	2.3	5.4	-1.2	2.3
Risk taking	1.9	2.8	7.9	0.7	-2.8
Ulcerative Colitis (UC)	1.8	3.3	5.8	-2.0	2.4
Wheeze or whistling in the chest in last year	1.8	3.2	8.1	2.9	1.2
Smoking status: Previous	1.8	2.7	4.7	-1.9	-2.2
Diabetes (father)	1.7	2.1	6.1	0.6	-2.5
Fed-up feelings	1.7	3.1	6.0	-1.9	2.4
Medication: Atenolol	1.7	2.2	3.6	-1.9	1.7
Pulse rate	1.7	2.9	5.1	-2.3	1.9
Loud music exposure frequency	1.7	1.8	3.4	-1.8	1.5
Number of operations (self-reported)	1.7	2.6	4.7	-1.7	2.2
Bipolar Disorder (2018)	1.6	2.6	6.0	-1.3	2.5
Blood White Count	1.6	11.9	26.1	5.1	3.1
Hypothyroidism (self reported)	1.6	3.6	8.8	3.0	-1.4
Medication: Ramipril	1.6	2.0	3.7	-1.9	-1.5
Shortness of breath walking on level ground	1.6	1.9	3.0	1.7	1.6
Medication: Lisinopril	1.6	2.1	5.8	-2.4	-0.8
Blood Red Count	1.5	14.8	37.9	-6.2	2.5
Sensitivity / hurt feelings	1.5	2.5	6.0	-2.5	1.2
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.8	1.4	1.9
Systolic blood pressure, automated reading	1.5	4.3	9.6	-3.1	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.3	-1.7	1.8
Impedance of arm (left)	1.5	6.7	14.9	-3.9	-2.3
Pain experienced in last month	1.5	2.4	5.1	-2.2	-1.5
Systolic Blood Pressure	1.4	6.9	16.1	-4.0	-2.1
Cardiovascular Disease	1.4	4.7	13.0	-3.6	-1.1
Impedance of leg (right)	1.4	6.7	19.8	-4.5	-0.4
Impedance of leg (left)	1.4	6.9	20.6	-4.5	-0.4
Past tobacco smoking	1.4	2.6	5.5	1.6	2.3
Health satisfaction	1.4	1.8	2.9	1.7	1.6
Guilty feelings	1.4	2.0	6.0	-2.4	-0.4
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.0	1.5	1.7
Alcohol drinker status: Previous	1.4	1.6	3.9	-0.9	2.0
Impedance of whole body	1.4	7.0	19.2	-4.4	-1.4
Severe depression (siblings)	1.3	1.5	4.4	2.1	0.2
Impedance of arm (right)	1.3	6.1	12.5	-3.5	-2.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.9	2.2	1.3
Comparative body size at age 10	1.3	3.6	10.5	3.2	0.4
Myopia	1.3	1.8	5.5	-2.3	0.1
Alzheimer’s Disease (in mother)	1.2	1.4	4.1	-0.0	-2.0
Lung FVC	1.2	6.2	12.2	-2.5	3.5
Medication: Co-codamol	1.2	1.4	4.0	2.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.8	-2.2	-0.8
Vascular/heart problems diagnosed by doctor	1.2	3.3	7.3	2.7	1.6
Bipolar Disorder or Schizophrenia	1.1	2.7	5.6	-1.5	2.4
Worry (Nagel 2018)	1.1	2.4	6.9	-2.6	0.6
Blood Eosinophil Count	1.1	8.8	25.6	5.1	1.0
Number of treatments/medications taken	1.1	2.0	6.0	-2.4	0.1
Relative age of first facial hair	1.1	2.2	5.9	-0.8	-2.4
Leg fat-free mass (left)	1.1	5.6	16.3	4.0	-0.8
High blood pressure	1.1	3.1	7.4	-2.7	-1.3
Number of incorrect matches in round	1.1	1.8	5.0	-2.2	0.5
Father’s age at death	1.1	1.5	4.4	-0.4	2.1
Worrier / anxious feelings	1.1	2.1	6.2	-2.5	0.5
Medication: Cholesterol lowering	1.1	1.8	4.8	-2.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.5	1.2	1.6
Hypertension (Self-reported)	1.1	3.1	8.4	-2.9	-0.9
Leg fat-free mass (right)	1.1	5.7	16.5	4.1	-0.8
Irritability	1.1	1.9	3.3	-1.5	1.8
Commuting to job workplace: Cycle	1.1	1.3	2.7	-1.1	1.6
Depressed Affect (Nagel 2018)	1.0	2.2	6.3	-2.5	0.6
Hand grip strength (left)	1.0	2.6	7.9	-0.1	-2.8
Leg predicted mass (left)	1.0	5.3	15.2	3.9	-0.9
Had other major operations	1.0	1.3	3.7	-0.3	1.9
Financial difficulties in last 2 years	1.0	1.4	3.5	0.9	1.9
Alcohol intake versus 10 years previously	1.0	1.5	4.0	-2.0	0.6
Medication: Aspirin	1.0	1.3	2.1	-1.4	-1.4
Illnesses of father: None of the above (group 1)	1.0	1.2	3.7	-1.9	0.2
Leg predicted mass (right)	1.0	5.6	16.2	4.0	-0.7
Miserableness	1.0	1.8	4.7	-2.2	0.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.5	-1.9	-0.1
Unable to work because of sickness or disability	1.0	1.3	3.0	1.0	1.7
Schizophrenia vs Biploar Disorder	0.9	1.2	3.7	1.9	0.0
Major Depression (MDD)	0.9	1.2	3.5	-1.9	0.0
Fasting Glucose	0.9	1.1	3.3	0.3	-1.8
HbA1C	0.9	1.0	2.0	1.4	-1.0
Blood Platelet Count	0.9	10.7	29.5	-5.4	1.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.2	-1.2	1.5
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.0	2.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.0	1.7	-0.1
Worry too long after embarrassment	0.9	1.5	3.8	-2.0	0.8
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.4	-0.8	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.3	-0.3	-1.8
Pulse rate, automated reading	0.9	3.0	4.7	-2.2	2.1
Overall health rating	0.9	1.9	4.2	2.0	1.2
Whole body fat-free mass	0.9	5.3	15.8	4.0	-0.4
Average weekly red wine intake	0.9	1.4	2.6	1.2	-1.6
Mood swings	0.9	1.6	2.7	-1.4	1.7
Loneliness, isolation	0.9	1.2	3.6	-0.1	1.9
Medication: Aspirin	0.9	1.1	1.9	-1.4	-1.2
Whole body water mass	0.9	5.0	14.7	3.8	-0.3
Basal metabolic rate	0.9	5.2	15.4	3.9	-0.6
Fractured/broken bones in last 5 years	0.9	1.2	3.5	1.9	-0.1
BMI	0.8	4.8	14.3	3.8	0.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.0	-1.4	-0.9
Vitamin and mineral supplements	0.8	1.1	2.2	1.1	-1.5
Hand grip strength (right)	0.8	2.2	6.3	0.6	-2.5
Relative age voice broke	0.8	1.3	3.6	0.4	-1.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-1.4	0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	1.6	0.6
Body mass index (BMI)	0.8	3.3	9.9	3.1	-0.2
Hearing difficulty/problems with background noise	0.8	1.2	3.4	-1.8	0.5
Trunk fat-free mass	0.8	4.6	13.7	3.7	0.1
Time employed in main current job	0.8	0.9	2.3	-1.5	-0.6
Trunk predicted mass	0.8	4.6	13.7	3.7	-0.1
Breastfed as a baby	0.8	1.0	1.5	-1.2	-1.2
Medication: Paracetamol	0.8	1.4	3.9	0.5	2.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.5	1.9	-1.2
Medication: Blood pressure	0.8	1.4	4.0	-2.0	-0.2
Supplements: Vitamin C	0.8	1.0	2.0	-1.4	-1.0
Knee pain experienced in last month	0.8	1.2	3.5	1.9	-0.3
Wears glasses or contact lenses	0.8	0.9	2.5	-1.6	0.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.1	1.5	0.8
Reaction Time	0.7	1.4	3.9	-0.5	2.0
Average weekly spirits intake	0.7	0.8	2.5	0.0	-1.6
Multivitamins +/- minerals	0.7	0.9	2.5	-0.3	1.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	-1.2	0.9
Allergy	0.7	1.7	4.8	-2.2	-0.6
Weight	0.7	3.4	9.6	3.1	-0.8
Illnesses of mother	0.7	0.9	2.6	1.6	-0.2
Arm fat mass (right)	0.7	3.0	6.9	2.6	-1.4
Medication: Amlodipine	0.7	1.0	2.9	0.2	-1.7
Qualifications: College or University degree	0.7	2.1	6.0	2.4	0.6
Ever had bowel cancer screening	0.7	0.8	1.6	0.9	-1.2
Medication for cholesterol	0.7	1.0	3.0	1.7	-0.1
Osteoarthritis (self-reported)	0.7	1.0	2.8	1.7	-0.4
Diastolic blood pressure, automated reading	0.7	2.2	5.3	-1.1	-2.3
Supplements: Calcium	0.7	0.8	1.8	-1.3	-0.8
Arm predicted mass (left)	0.7	3.4	10.2	3.2	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.4	1.5	0.1
Crohns Disease (2012)	0.6	0.9	2.7	-1.6	0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	-1.1	0.9
Angina	0.6	0.8	1.4	-1.1	1.2
Townsend deprivation index at recruitment	0.6	0.9	1.8	-0.9	1.4
Nervous feelings	0.6	1.1	2.5	-1.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-1.3	0.6
Qualifications: None of the above	0.6	1.3	2.1	-1.3	-1.5
Asthma	0.6	1.1	3.3	1.8	-0.2
Glaucoma (self-reported)	0.6	0.7	2.1	1.5	-0.2
High blood pressure (siblings)	0.6	0.8	2.5	-1.6	-0.2
Arm fat-free mass (right)	0.6	3.1	9.2	3.0	0.4
Medication for pain relief, constipation, heartburn	0.6	1.0	3.0	-0.1	-1.7
Medication: Omeprazole	0.6	0.7	1.6	-1.3	0.7
Mean time to correctly identify matches	0.6	1.1	1.7	-1.3	1.2
Leg fat mass (right)	0.6	2.2	6.2	2.5	-0.6
Arm predicted mass (right)	0.6	3.0	8.7	3.0	0.6
Commuting to job workplace: Walk	0.6	0.7	2.1	-1.4	-0.0
Eye problems/disorders: Cataract	0.6	0.7	1.4	-1.2	0.8
Asthma (self-reported)	0.6	1.2	3.6	1.9	-0.3
Arm fat mass (left)	0.6	2.4	6.1	2.5	-1.1
Mother’s age at death	0.6	0.7	1.3	-0.9	-1.2
Commuting to job workplace: Public transport	0.6	0.7	2.1	1.5	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	1.1	-0.9
Medication: Atorvastatin	0.6	0.8	1.9	-1.4	-0.6
Illnesses of father: High blood pressure	0.6	0.7	1.6	0.8	-1.3
Arm fat-free mass (left)	0.6	3.3	9.9	3.1	-0.0
Average weekly beer plus cider intake	0.6	0.9	1.7	-1.0	-1.3
Ever depressed for a whole week	0.6	0.7	1.6	-1.2	0.8
Depression (Nagel 2018)	0.5	0.7	1.1	-1.0	1.1
Alzheimer’s Disease (including proxy)	0.5	0.8	2.0	0.6	-1.4
HDL Cholesterol	0.5	0.8	2.4	-0.4	-1.6
Triglycerides	0.5	0.8	2.0	-0.6	1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.4	1.2	0.7
Allergy or Eczema	0.5	1.2	3.3	0.6	1.8
Qualifications: CSEs or equivalent	0.5	0.7	2.1	0.1	1.5
Had menopause	0.5	0.6	1.4	-1.2	-0.5
Arm fat percentage (right)	0.5	2.0	3.0	1.7	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	0.6	1.5
Mouth/teeth dental problems: Dentures	0.5	0.9	2.4	1.5	-0.5
Peak expiratory flow (PEF)	0.5	1.2	3.5	-1.9	-0.5
Angina (self-reported)	0.5	0.7	1.0	-1.0	1.0
Whole body fat mass	0.5	2.2	4.9	2.2	-1.3
Chest pain or discomfort	0.5	0.8	1.4	1.0	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.0	0.7	1.0
Friendships satisfaction	0.5	0.6	1.6	-0.5	1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.2	-1.0	1.1
Breast cancer (self-reported)	0.5	0.6	1.1	-1.1	0.9
Medication: Gliclazide	0.5	0.6	1.8	-0.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.2	-1.1	1.5
Number of self-reported non-cancer illnesses	0.5	0.8	1.9	-1.4	-0.8
Medication: Blood pressure	0.5	0.9	2.7	-1.6	-0.1
Ever smoked	0.5	0.8	2.0	-0.7	-1.4
Leg fat mass (left)	0.5	2.1	5.8	2.4	-0.6
Lupus	0.4	0.6	1.9	1.4	-0.1
Respiratory disease	0.4	0.9	2.4	1.5	0.5
Chronotype (morning person)	0.4	0.9	2.5	-0.5	-1.6
Pack years adult smoking proportion	0.4	0.5	1.3	0.6	1.1
Serious illness, injury or assault to yourself	0.4	0.5	1.5	0.2	1.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.7	0.4	1.6
Medication: Levothyroxine sodium	0.4	0.6	1.7	1.3	-0.3
High blood pressure (mother)	0.4	0.5	1.6	0.1	1.3
Waist circumference	0.4	1.3	3.8	2.0	-0.4
Illnesses of siblings	0.4	0.6	1.7	1.3	0.3
Length of working week for main job	0.4	0.4	0.6	0.8	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.6	1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	0.2	1.2
Eye problems/disorders: None of the above	0.4	0.5	1.3	-0.5	-1.1
Suffer from ‘nerves’	0.4	0.6	1.4	-1.2	0.6
Age at last live birth	0.4	0.6	1.3	1.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.8	1.7	-0.0
Arm fat percentage (left)	0.4	1.7	3.2	1.8	-1.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	-1.1	0.5
Mineral and other dietary supplements	0.4	0.6	1.6	1.3	-0.3
Medication: Paracetamol	0.4	0.6	1.7	0.0	1.3
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.7	0.6
Breast Cancer	0.3	0.8	2.2	0.3	1.5
Rheumatoid Arthritis	0.3	0.5	1.0	1.0	-0.6
Ulcerative Colitis	0.3	0.4	1.2	-1.1	0.0
Heel T-Score	0.3	2.0	5.2	-2.3	-0.9
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-0.9	-0.9
Age when periods started (menarche)	0.3	0.6	1.9	-0.2	-1.4
Trunk fat mass	0.3	1.4	2.4	1.6	-1.3
Alcohol usually taken with meals	0.3	0.5	1.1	1.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	-0.4	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	0.8	0.8
Pain all over the body in last month	0.3	0.4	0.7	-0.6	-0.8
Hip circumference	0.3	1.2	3.5	1.9	-0.2
Falls in the last year	0.3	0.4	0.6	0.8	-0.8
Medication: Lansoprazole	0.3	0.4	1.2	-0.1	1.1
Body fat percentage	0.3	1.0	2.0	1.0	-1.4
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.5	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-1.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	-1.0	-0.2
Neck or shoulder pain in last month	0.3	0.5	1.4	0.1	1.2
Medication: Ibuprofen	0.3	0.3	0.7	-0.8	-0.5
Medication: Seretide 50 evohaler	0.3	0.4	0.8	0.6	-0.9
Alcohol intake frequency.	0.3	0.6	1.5	0.5	1.2
Leg pain on walking	0.3	0.4	1.0	0.6	1.0
Osteoporosis (self-reported)	0.3	0.4	0.9	0.9	-0.6
High cholesterol (Self-reported)	0.3	0.6	1.7	-1.3	0.0
Medication: Bendroflumethiazide	0.3	0.4	0.9	-0.6	1.0
Alcohol drinker status: Never	0.3	0.3	0.9	1.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.3	1.0
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.9	0.0
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.7	0.0
Trunk fat percentage	0.2	0.9	2.4	0.4	-1.6
Current tobacco smoking	0.2	0.4	0.9	0.9	0.5
Average weekly fortified wine intake	0.2	0.3	0.6	-0.8	-0.5
Maternal smoking around birth	0.2	0.3	0.7	-0.1	0.9
Supplements: Glucosamine	0.2	0.2	0.4	-0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.1	-1.0
Mouth/teeth dental problems	0.2	0.3	1.0	-1.0	-0.1
Diabetes (self-reported)	0.2	0.3	0.9	-1.0	-0.1
Fluid intelligence score	0.2	0.5	1.4	-0.3	-1.2
Number of live births	0.2	0.3	0.8	0.9	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.5	1.2
Prospective memory result	0.2	0.3	0.8	0.1	0.9
Lung cancer (father)	0.2	0.3	0.8	0.9	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.8	0.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.8	0.4
Pulse wave peak to peak time	0.2	0.3	0.6	0.8	-0.4
Number of full sisters	0.2	0.3	0.8	-0.9	0.2
Illnesses of father: Heart disease	0.2	0.3	0.8	0.3	-0.9
Smoking status: Current	0.2	0.3	0.9	0.9	-0.1
Financial situation satisfaction	0.2	0.2	0.6	-0.1	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.9	0.2
Heart disease (siblings)	0.2	0.2	0.5	-0.7	-0.2
Pack years of smoking	0.2	0.2	0.5	0.4	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	-0.8	-0.0
Schizophrenia (2018)	0.1	0.3	0.8	-0.9	0.0
Ovarian Cancer	0.1	0.2	0.3	0.5	0.6
Mean Putamen Volume	0.1	0.1	0.4	0.6	-0.0
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.6	-0.3
Schizophrenia (2014)	0.1	0.1	0.4	-0.6	0.0
Waist Hip Ratio (WHR)	0.1	0.6	1.3	-1.1	0.6
Smoking Status	0.1	0.3	0.8	-0.5	-0.9
Hair Pigment	0.1	2.7	5.0	-2.2	-1.8
Supplements: Zinc	0.1	0.1	0.2	-0.4	0.1
Diabetes (mother)	0.1	0.2	0.4	-0.6	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.1	-0.7
Stomach or abdominal pain in last month	0.1	0.2	0.5	-0.7	-0.0
Forced vital capacity (FVC)	0.1	0.6	1.0	-0.8	1.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.6	0.1
Medication: Simvastatin	0.1	0.1	0.3	-0.5	0.3
Noisy workplace	0.1	0.1	0.3	0.2	-0.5
Depression (self-reported)	0.1	0.1	0.2	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.3	-0.2	1.2
Standing height	0.1	0.8	2.2	0.3	-1.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	0.7	-0.2
Pulse wave reflection index	0.1	0.1	0.2	-0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.4	0.6	-0.3
Gout (self-reported)	0.1	0.1	0.2	0.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	-0.1	-0.7
Birth weight	0.1	0.3	0.6	0.5	-0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.6	0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-0.7	0.9
Leg fat percentage (right)	0.1	0.5	1.4	1.2	-0.4
Number of full brothers	0.1	0.1	0.2	0.4	-0.2
Migraine (self-reported)	0.1	0.1	0.2	0.5	0.1
Comparative height size at age 10	0.1	0.5	0.8	-0.9	-0.8
Had major operations	0.1	0.2	0.4	-0.7	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.5	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.7	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.8	-0.2
Back pain experienced in last month	0.1	0.2	0.4	-0.7	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.4	-0.0
Hearing aid user	0.1	0.1	0.4	0.6	-0.0
Leg fat percentage (left)	0.1	0.5	1.3	1.1	-0.3
Cholesterol lowering medication	0.1	0.2	0.4	-0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.3
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	0.0	-0.5
Prostate Cancer	0.0	0.0	0.1	-0.0	0.2
Age at First Birth	0.0	0.0	0.1	-0.0	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.2	0.4	-0.3	-0.6
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.1	0.4
Lung FEV1/FVC ratio	0.0	0.2	0.6	0.8	-0.1
Tanning	0.0	0.3	0.8	0.9	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.3	0.2
Medication: Metformin	0.0	0.0	0.0	-0.2	0.1
Taking other prescription medications	0.0	0.0	0.1	-0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.3	0.1
Sitting height	0.0	0.0	0.0	-0.1	-0.2
Heart attack	0.0	0.1	0.2	0.1	-0.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.2	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	-0.1	-0.2
Birth weight of first child	0.0	0.0	0.1	0.3	0.2
Number of children fathered	0.0	0.0	0.1	-0.1	-0.3
Age at first live birth	0.0	0.1	0.2	0.4	0.1
Medication: Allopurinol	0.0	0.1	0.1	0.2	0.4
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.2	0.3
Qualifications: nursing, teaching	0.0	0.0	0.0	0.2	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.0	-0.2

Hub : Genes

LRRC10B

Models

Trait associations