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chr16:88,013,385-90,172,696

Best TWAS P=1.5e-29 · Best GWAS P=1.3e-78 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
63	GTEx	Uterus	SNAI3-AS1	0.47	0.00	enet	13	0.04	5.3e-02	-2.85	11.3	1.5e-29	0.56	0.02	0.53	TRUE
4	GTEx	Adipose Subcutaneous	DEF8	0.11	0.02	enet	16	0.06	1.3e-05	-4.08	-8.7	3.9e-18	-0.03	0.28	0.16	TRUE
9	GTEx	Artery Aorta	GALNS	0.22	0.05	lasso	7	0.01	6.0e-02	4.72	-8.5	1.5e-17	-0.26	0.15	0.04	TRUE
78	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RNF166	0.11	0.06	blup	67	0.07	1.4e-06	-5.66	8.2	2.4e-16	0.16	0.43	0.39	TRUE
75	YFS	Blood	RNF166	0.25	0.07	bslmm	345	0.14	6.9e-45	3.34	6.3	3.9e-10	0.10	1.00	0.00	TRUE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SPG7	0.05	0.01	blup	59	0.03	3.7e-04	7.64	6.2	4.6e-10	0.09	0.00	0.98	TRUE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GALNS	0.08	0.02	blup	61	0.04	3.4e-05	4.32	-5.5	3.0e-08	-0.02	0.73	0.01	TRUE
39	GTEx	Muscle Skeletal	RP11-46C24.7	0.08	0.05	enet	12	0.05	1.4e-05	-2.11	5.5	5.0e-08	0.03	0.71	0.01	TRUE
103	The Cancer Genome Atlas	Soft Tissue Sarcoma	CTU2	0.09	0.02	lasso	4	0.03	9.4e-03	-4.49	5.4	5.9e-08	0.20	0.06	0.10	TRUE
21	GTEx	Colon Sigmoid	CDK10	0.37	0.12	lasso	8	0.22	2.2e-08	-7.13	5.3	1.3e-07	0.07	0.30	0.51	TRUE
74	YFS	Blood	MVD	0.02	0.00	bslmm	333	0.01	2.2e-03	-4.49	8.5	1.8e-17	0.23	0.06	0.02	FALSE
89	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDK10	0.15	0.03	blup	42	0.08	3.7e-09	-5.12	8.3	8.6e-17	0.06	0.08	0.85	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	CDK10	0.38	0.28	lasso	4	0.29	5.6e-11	-7.14	8.2	2.0e-16	0.10	0.20	0.80	FALSE
51	GTEx	Skin Sun Exposed Lower leg	CHMP1A	0.36	0.11	enet	29	0.19	1.5e-15	-6.35	-8.2	2.6e-16	-0.03	0.98	0.02	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDK10	0.06	0.00	blup	43	0.02	2.2e-03	3.74	8.2	3.2e-16	0.02	0.00	0.12	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	CHMP1A	0.25	0.01	enet	21	0.08	5.3e-05	-6.35	-7.9	2.0e-15	0.01	0.50	0.05	FALSE
25	GTEx	Esophagus Mucosa	CDK10	0.36	0.15	lasso	6	0.23	1.9e-15	-7.13	7.9	2.4e-15	0.09	0.20	0.80	FALSE
47	GTEx	Prostate	CDK10	0.41	0.16	lasso	6	0.24	1.0e-06	-7.13	7.9	2.5e-15	0.10	0.12	0.28	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	CDK10	0.06	0.04	blup	43	0.04	8.9e-05	-5.12	7.8	9.5e-15	0.03	0.03	0.94	FALSE
54	GTEx	Small Intestine Terminal Ileum	VPS9D1	0.34	0.04	enet	11	0.11	2.4e-03	-7.13	-7.7	1.3e-14	-0.09	0.13	0.18	FALSE
64	GTEx	Whole Blood	MC1R	0.08	0.00	enet	18	0.00	5.5e-01	-3.29	7.7	2.1e-14	0.05	0.05	0.04	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RNF166	0.11	0.05	blup	66	0.07	1.0e-08	-5.66	7.5	4.3e-14	0.19	0.78	0.16	FALSE
69	METSIM	Adipose	CTU2	0.05	0.00	blup	383	0.00	8.3e-02	5.30	7.5	4.5e-14	0.09	0.16	0.03	FALSE
73	YFS	Blood	DEF8	0.12	0.06	bslmm	285	0.10	9.6e-31	-3.82	-7.5	4.9e-14	-0.06	1.00	0.00	FALSE
61	GTEx	Thyroid	CHMP1A	0.27	0.00	enet	39	0.08	1.2e-06	5.02	-7.5	5.5e-14	-0.03	0.11	0.19	FALSE
96	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CBFA2T3	0.08	0.06	blup	61	0.08	4.2e-04	-4.63	7.5	8.0e-14	0.16	0.01	0.80	FALSE
98	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MC1R	0.18	-0.01	blup	50	0.04	9.9e-03	3.62	7.5	8.1e-14	0.06	0.01	0.12	FALSE
16	GTEx	Brain Putamen basal ganglia	CYBA	0.53	0.01	enet	54	0.08	5.9e-03	2.73	7.3	3.2e-13	0.20	0.04	0.06	FALSE
59	GTEx	Testis	CDK10	0.28	0.14	lasso	6	0.24	4.1e-11	-4.89	7.3	3.5e-13	0.06	0.53	0.46	FALSE
97	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDK10	0.20	0.02	enet	15	0.08	5.3e-04	-6.35	7.3	3.9e-13	0.08	0.00	0.92	FALSE
67	METSIM	Adipose	CDK10	0.23	0.14	lasso	12	0.21	7.9e-31	-7.13	7.2	4.3e-13	0.09	0.20	0.80	FALSE
38	GTEx	Muscle Skeletal	RP5-1142A6.5	0.09	0.02	enet	19	0.02	3.2e-03	-5.66	7.2	7.3e-13	0.25	0.19	0.13	FALSE
42	GTEx	Ovary	CDK10	0.45	0.11	lasso	8	0.25	6.8e-07	-7.13	7.1	1.3e-12	0.07	0.19	0.31	FALSE
37	GTEx	Muscle Skeletal	CDK10	0.17	0.12	lasso	6	0.10	9.2e-10	-7.13	7.0	1.7e-12	0.09	0.20	0.80	FALSE
3	GTEx	Adipose Subcutaneous	CHMP1A	0.29	0.07	enet	35	0.12	2.0e-10	-6.35	-7.0	1.8e-12	0.00	0.48	0.07	FALSE
17	GTEx	Breast Mammary Tissue	SNAI3-AS1	0.22	0.08	lasso	4	0.17	6.6e-09	-2.85	7.0	1.8e-12	0.23	0.58	0.02	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CBFA2T3	0.04	0.04	lasso	3	0.03	1.2e-04	-6.80	7.0	1.8e-12	0.15	0.00	0.99	FALSE
7	GTEx	Adipose Visceral Omentum	CDK10	0.43	0.19	lasso	6	0.32	3.6e-17	-7.13	7.0	2.6e-12	0.07	0.20	0.80	FALSE
45	GTEx	Pancreas	RP11-830F9.5	0.50	0.19	lasso	11	0.20	4.6e-09	-7.73	7.0	3.8e-12	0.12	0.97	0.00	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	ACSF3	0.18	0.01	enet	13	0.09	1.8e-09	-1.93	6.9	4.5e-12	0.08	0.40	0.38	FALSE
23	GTEx	Colon Transverse	CDK10	0.34	0.15	lasso	5	0.16	4.2e-08	-5.04	6.9	4.6e-12	0.06	0.81	0.12	FALSE
34	GTEx	Lung	CDK10	0.25	0.18	lasso	7	0.19	1.0e-14	-5.04	6.9	7.0e-12	0.06	1.00	0.00	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	CDK10	0.27	0.19	lasso	9	0.28	1.2e-15	-5.12	6.9	7.1e-12	0.07	0.57	0.43	FALSE
30	GTEx	Heart Atrial Appendage	CDK10	0.26	0.07	lasso	3	0.13	1.4e-06	2.62	6.8	8.8e-12	0.01	0.28	0.37	FALSE
70	METSIM	Adipose	RP11-368I7.4	0.04	0.03	enet	12	0.02	2.2e-04	-7.13	-6.8	9.4e-12	-0.05	0.23	0.66	FALSE
53	GTEx	Skin Sun Exposed Lower leg	VPS9D1-AS1	0.18	0.04	lasso	5	0.06	1.2e-05	-4.88	-6.8	1.0e-11	-0.07	0.43	0.53	FALSE
26	GTEx	Esophagus Muscularis	VPS9D1	0.18	0.02	lasso	3	0.03	4.0e-03	-4.83	-6.7	1.8e-11	-0.05	0.16	0.14	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPG7	0.07	0.03	enet	11	0.04	3.7e-05	2.96	6.7	1.9e-11	0.07	0.01	0.96	FALSE
66	METSIM	Adipose	ACSF3	0.05	0.02	blup	444	0.03	1.6e-05	3.84	6.7	2.1e-11	0.26	0.94	0.00	FALSE
58	GTEx	Stomach	CDK10	0.35	0.12	enet	12	0.22	6.4e-11	-7.14	6.7	2.7e-11	0.07	0.21	0.76	FALSE
36	GTEx	Muscle Skeletal	RNF166	0.15	0.13	lasso	6	0.12	1.5e-11	-5.66	6.6	3.2e-11	0.23	1.00	0.00	FALSE
41	GTEx	Nerve Tibial	CDK10	0.42	0.28	enet	16	0.35	1.2e-25	-5.12	6.5	6.5e-11	0.05	1.00	0.00	FALSE
11	GTEx	Artery Tibial	CHMP1A	0.21	0.06	enet	34	0.11	7.3e-09	-6.35	-6.5	6.6e-11	0.00	0.12	0.05	FALSE
6	GTEx	Adipose Subcutaneous	CDK10	0.37	0.20	enet	50	0.26	4.0e-21	-5.12	6.5	6.8e-11	0.05	0.98	0.02	FALSE
52	GTEx	Skin Sun Exposed Lower leg	CDK10	0.30	0.18	enet	18	0.29	3.0e-24	-7.13	6.5	6.8e-11	0.05	0.21	0.79	FALSE
43	GTEx	Pancreas	CBFA2T3	0.56	0.20	enet	36	0.26	2.9e-11	-7.73	6.4	1.2e-10	0.11	1.00	0.00	FALSE
29	GTEx	Esophagus Muscularis	RP11-46C24.7	0.28	0.12	enet	22	0.15	1.4e-09	-2.11	6.4	1.3e-10	0.07	1.00	0.00	FALSE
12	GTEx	Artery Tibial	CDK10	0.29	0.10	enet	15	0.22	2.4e-17	-7.14	6.4	1.8e-10	0.08	0.28	0.72	FALSE
46	GTEx	Pituitary	VPS9D1-AS1	0.21	-0.01	lasso	9	-0.01	5.7e-01	-7.13	-6.3	2.3e-10	-0.04	0.06	0.07	FALSE
57	GTEx	Stomach	GAS8	0.16	-0.01	enet	26	0.06	7.0e-04	-2.79	-6.3	2.9e-10	-0.04	0.02	0.62	FALSE
32	GTEx	Heart Left Ventricle	PIEZO1	0.16	0.00	enet	22	0.01	6.7e-02	8.65	-6.3	3.4e-10	-0.18	0.07	0.09	FALSE
99	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRAPPC2L	0.15	0.01	blup	43	0.09	1.7e-04	3.60	-6.3	3.4e-10	-0.13	0.18	0.20	FALSE
15	GTEx	Brain Hypothalamus	CTU2	0.34	0.01	lasso	7	0.02	1.3e-01	5.73	6.1	1.1e-09	0.07	0.03	0.35	FALSE
76	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHMP1A	0.10	0.07	lasso	2	0.09	6.7e-08	-6.35	-6.1	1.3e-09	-0.03	0.00	1.00	FALSE
28	GTEx	Esophagus Muscularis	CDK10	0.24	0.11	enet	19	0.14	4.3e-09	-7.13	6.0	1.5e-09	0.06	0.20	0.80	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	GALNS	0.24	0.21	blup	61	0.21	6.4e-20	4.72	-6.0	1.5e-09	-0.14	1.00	0.00	FALSE
8	GTEx	Adrenal Gland	CDK10	0.26	0.04	enet	11	0.16	2.7e-06	-7.14	6.0	1.7e-09	0.11	0.09	0.18	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHMP1A	0.07	0.03	blup	37	0.03	1.3e-04	-6.35	-6.0	1.9e-09	-0.02	0.00	0.99	FALSE
72	YFS	Blood	CBFA2T3	0.02	0.00	bslmm	429	0.01	1.1e-04	2.06	6.0	2.2e-09	0.36	0.06	0.19	FALSE
20	GTEx	Cells Transformed fibroblasts	ZNF276	0.13	0.01	enet	21	0.02	1.9e-02	-0.43	-6.0	2.5e-09	-0.04	0.05	0.36	FALSE
80	The Cancer Genome Atlas	Glioblastoma Multiforme	SNAI3	0.19	0.06	enet	7	0.12	1.6e-04	5.30	-5.9	4.5e-09	-0.24	0.04	0.11	FALSE
18	GTEx	Breast Mammary Tissue (Female)	SNAI3-AS1	0.18	0.04	lasso	3	0.08	1.8e-03	-2.85	5.8	5.7e-09	0.20	0.07	0.06	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	DEF8	0.19	0.16	lasso	13	0.16	2.5e-09	3.79	-5.8	5.7e-09	0.01	0.98	0.00	FALSE
14	GTEx	Brain Cerebellum	CDK10	0.44	0.12	enet	23	0.28	5.1e-09	-7.13	5.8	5.8e-09	0.06	0.24	0.72	FALSE
31	GTEx	Heart Atrial Appendage	SNAI3-AS1	0.25	0.04	lasso	8	0.10	3.1e-05	-2.85	5.8	6.7e-09	0.27	0.26	0.05	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	RNF166	0.07	0.06	lasso	2	0.05	1.2e-06	-5.66	5.8	7.8e-09	0.18	0.97	0.01	FALSE
62	GTEx	Thyroid	CDK10	0.36	0.16	lasso	9	0.21	9.7e-16	4.26	5.8	8.1e-09	0.04	1.00	0.00	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF276	0.04	0.02	blup	46	0.01	1.3e-02	4.50	-5.8	8.1e-09	0.09	0.03	0.46	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SPIRE2	0.10	0.05	lasso	4	0.04	1.5e-05	-4.79	5.7	9.7e-09	0.02	0.36	0.03	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPEP1	0.06	0.01	blup	44	0.02	1.6e-03	-4.08	-5.7	1.2e-08	0.06	0.16	0.20	FALSE
56	GTEx	Spleen	CDK10	0.36	0.22	enet	6	0.06	1.3e-02	-5.04	5.7	1.4e-08	0.03	0.24	0.05	FALSE
65	GTEx	Whole Blood	SNAI3-AS1	0.15	0.04	enet	21	0.10	6.7e-10	5.11	5.7	1.4e-08	0.29	0.88	0.06	FALSE
33	GTEx	Lung	SPATA33	0.15	0.11	enet	9	0.13	5.6e-10	-5.12	5.7	1.6e-08	0.03	1.00	0.00	FALSE
55	GTEx	Spleen	SPATA33	0.20	0.00	lasso	5	0.01	1.5e-01	-4.89	-5.6	1.8e-08	-0.05	0.10	0.05	FALSE
27	GTEx	Esophagus Muscularis	CHMP1A	0.15	0.01	enet	32	0.09	6.6e-06	0.72	-5.6	2.0e-08	-0.02	0.07	0.10	FALSE
87	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FANCA	0.22	0.20	lasso	8	0.26	7.9e-15	4.35	5.6	2.0e-08	-0.05	0.05	0.86	FALSE
22	GTEx	Colon Transverse	TRAPPC2L	0.27	0.08	lasso	9	0.13	1.3e-06	3.51	-5.6	2.4e-08	-0.09	0.78	0.10	FALSE
68	METSIM	Adipose	CHMP1A	0.27	0.05	lasso	9	0.07	1.3e-10	-6.35	-5.6	2.8e-08	-0.10	0.90	0.06	FALSE
60	GTEx	Thyroid	VPS9D1	0.16	0.08	lasso	4	0.09	3.7e-07	-6.35	-5.5	3.6e-08	-0.07	0.96	0.02	FALSE
93	The Cancer Genome Atlas	Lung Adenocarcinoma	CTU2	0.05	0.05	lasso	2	0.04	1.7e-05	-5.66	5.5	3.9e-08	0.19	0.58	0.04	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNF166	0.15	0.15	lasso	4	0.15	1.0e-15	-5.66	5.5	3.9e-08	0.16	1.00	0.00	FALSE
13	GTEx	Artery Tibial	FANCA	0.14	0.05	enet	17	0.05	8.2e-05	2.43	5.4	5.3e-08	0.04	0.37	0.03	FALSE
10	GTEx	Artery Aorta	CDK10	0.33	0.07	enet	27	0.18	2.7e-10	-7.14	5.4	7.9e-08	0.08	0.20	0.80	FALSE
35	GTEx	Lung	SNAI3-AS1	0.14	0.02	enet	18	0.05	6.4e-05	-1.53	5.3	8.6e-08	0.26	0.19	0.16	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CDK10	0.27	0.14	lasso	9	0.21	6.9e-25	-7.13	5.3	8.9e-08	0.07	0.20	0.80	FALSE
88	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPIRE2	0.19	0.07	enet	11	0.15	1.0e-08	4.47	5.3	9.0e-08	-0.05	0.53	0.12	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	RNF166	0.23	0.12	enet	20	0.18	2.3e-13	-4.49	5.3	9.2e-08	0.10	1.00	0.00	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK10	0.11	0.02	blup	42	0.06	3.0e-07	2.58	5.3	9.6e-08	0.11	0.20	0.18	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RNF166	0.14	0.07	blup	67	0.11	1.1e-12	-4.49	5.3	1.0e-07	0.14	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	DEF8	0.08	0.05	enet	6	0.05	3.2e-04	3.79	-5.3	1.1e-07	0.00	0.30	0.04	FALSE
19	GTEx	Cells Transformed fibroblasts	RNF166	0.24	0.19	lasso	4	0.20	9.5e-15	-5.66	5.3	1.2e-07	0.20	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	CDH15	0.18	0.02	blup	44	0.07	4.2e-05	6.04	-5.3	1.2e-07	-0.14	0.01	0.97	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	RNF166	0.21	0.18	enet	15	0.18	1.1e-17	-5.66	5.3	1.2e-07	0.16	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	SPATA33	0.17	0.12	lasso	6	0.12	5.6e-10	4.61	5.3	1.5e-07	0.01	1.00	0.00	FALSE
44	GTEx	Pancreas	TRAPPC2L	0.25	0.16	lasso	6	0.10	3.4e-05	3.51	-5.2	1.9e-07	-0.08	0.53	0.03	FALSE
71	NTR	Blood	RPL13	0.02	0.01	bslmm	365	0.01	5.9e-05	-4.56	-5.2	2.0e-07	-0.09	0.94	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SPG7	0.14	0.06	blup	445	0.10	3.2e-12	-4.04	5.2	2.4e-07	0.01	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CTU2	0.06	0.03	blup	67	0.03	1.3e-03	-5.66	5.2	2.4e-07	0.05	0.05	0.05	FALSE