TWAS hub - MVD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0204	0.0092	0.0074	-0.001	0.006	-0.001	0.007	-0.001	0.7700	0.00240	0.7800	0.0022	0.9800
2	TCGA	Breast Invasive Carcinoma	0.0233	0.0125	0.0083	0.012	0.000	0.008	NA	0.008	0.0015	0.28000	0.0089	NA	0.0067
3	TCGA	Lung Squamous Cell Carcinoma	0.0570	0.0286	0.0027	0.021	0.026	0.014	NA	0.018	0.0016	0.00059	0.0090	NA	0.0038

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hair Pigment	11.6	330.2	640.1	-12.2	14.2	25.3
Tanning	9.3	114.1	243.4	4.1	-9.1	-15.6
Mood swings	6.5	11.8	32.8	-5.7	-0.4	-1.6
Leg pain on walking	4.7	5.9	9.2	-0.8	-2.8	-3.0
Pain experienced in last month	4.7	7.9	15.4	3.9	0.7	2.8
Depressed Affect (Nagel 2018)	4.5	9.4	25.8	-5.1	0.5	-1.5
Medication: Lansoprazole	4.5	5.1	9.0	-2.0	-1.6	-3.0
Wheeze or whistling in the chest in last year	4.5	8.0	17.9	-4.2	1.8	-1.7
Neuroticism	4.2	10.2	29.0	-5.4	0.3	-1.2
Fed-up feelings	4.0	7.2	17.0	-4.1	-0.2	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	5.3	8.6	-1.7	-2.0	-2.9
Angina (self-reported)	3.9	5.1	8.5	-1.3	-2.9	-2.3
Medication: Blood pressure	3.9	7.4	10.8	-1.8	2.8	3.3
Medication: Bendroflumethiazide	3.9	5.9	10.1	-3.2	2.2	1.6
Number of incorrect matches in round	3.8	6.3	10.3	0.7	-2.9	-3.2
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	11.0	-3.3	1.5	-1.0
Knee pain experienced in last month	3.7	5.7	12.0	-1.4	-1.8	-3.5
Angina	3.6	4.8	7.1	-1.2	-2.7	-2.4
Asthma (self-reported)	3.5	7.0	17.3	-4.2	0.9	-1.7
Irritability	3.5	6.0	16.6	-4.1	0.4	-1.1
Neuroticism score	3.4	7.2	20.4	-4.5	-0.1	-1.1
Asthma	3.4	6.7	16.6	-4.1	0.8	-1.6
Medication: Ibuprofen	3.3	4.0	9.4	-3.1	1.2	-1.0
Neuroticism (Nagel 2018)	3.2	7.5	20.9	-4.6	0.7	-1.1
Respiratory disease	3.2	7.2	17.2	-4.1	2.1	-0.3
Osteoarthritis (self-reported)	3.1	4.1	7.6	-1.4	-1.6	-2.8
Blood Red Count	2.9	28.1	72.4	8.5	2.3	2.6
Severe depression (siblings)	2.9	3.2	8.1	-2.9	-0.7	-1.0
Mouth/teeth dental problems: Bleeding gums	2.9	3.8	7.8	-2.8	-1.8	-0.4
Osteoporosis (self-reported)	2.9	3.6	7.4	2.7	-1.8	0.1
Tinnitus: Yes, now most or all of the time	2.9	3.4	7.2	-1.7	-0.1	2.7
Medication: Paracetamol	2.8	4.7	9.9	-1.8	1.0	-3.1
Miserableness	2.8	4.8	13.6	-3.7	0.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.3	11.0	-3.3	-0.8	-1.2
Health satisfaction	2.7	3.5	5.7	-2.4	-1.5	-1.7
Medication: Lisinopril	2.7	3.5	6.1	-2.5	1.5	1.4
Pain type(s) experienced in last month: Hip pain	2.6	3.3	5.6	-0.3	-2.0	-2.4
Neck or shoulder pain in last month	2.5	3.5	4.1	-2.0	-1.6	-2.0
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	5.0	0.1	-1.7	-2.2
Medication: Levothyroxine sodium	2.4	4.1	10.4	3.2	-1.2	0.6
Mouth/teeth dental problems	2.4	3.6	8.6	2.9	1.2	0.9
HDL Cholesterol	2.3	3.9	9.4	3.1	0.6	1.4
Financial situation satisfaction	2.3	2.8	5.9	-1.4	2.4	0.8
Chest pain or discomfort	2.2	3.2	5.8	-2.4	-0.3	-1.9
Handedness (chirality/laterality): Left-handed	2.2	2.7	7.8	0.3	-0.2	2.8
Mean Putamen Volume	2.1	2.4	3.6	-1.9	-0.5	-1.8
HbA1C	2.1	2.3	6.2	-2.5	-0.7	-0.5
Stomach or abdominal pain in last month	2.1	2.6	6.9	-0.6	-0.7	-2.6
Depression (self-reported)	2.1	2.5	3.6	-1.9	-1.3	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	15.5	3.9	-1.6	-1.4
Emphysema/chronic bronchitis	2.1	2.4	4.9	1.2	-2.2	-0.8
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	5.8	2.4	-1.2	0.5
Supplements: Calcium	2.1	2.3	6.2	2.5	-0.2	0.9
Ovarian Cancer	2.0	2.6	6.3	1.1	2.5	0.5
Lung FEV1/FVC ratio	2.0	9.9	15.6	0.4	-3.7	-3.9
Frequency of depressed mood in last 2 weeks	2.0	2.9	4.7	-2.2	-1.0	-1.7
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.0	1.5	-0.5	-2.0
Pack years adult smoking proportion	2.0	3.1	5.5	-0.2	-2.3	-2.0
Weight	2.0	10.0	23.0	0.7	-2.6	-4.8
Time employed in main current job	2.0	2.3	4.2	-0.6	-2.1	-1.5
Hypothyroidism/myxoedema (self-reported)	2.0	4.0	11.2	3.3	-0.8	-0.2
Average weekly beer plus cider intake	2.0	2.9	6.2	-1.6	2.5	-0.2
Height	1.9	37.5	62.6	5.8	-4.0	-7.9
Leg fat-free mass (left)	1.9	10.2	18.7	1.5	-3.1	-4.3
Average weekly fortified wine intake	1.9	2.2	3.2	-1.5	1.1	1.8
Taking other prescription medications	1.9	2.9	7.3	-0.2	-1.1	-2.7
Leg predicted mass (left)	1.9	10.0	18.1	1.6	-3.0	-4.3
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	12.8	3.6	-1.9	-1.7
Pulse wave reflection index	1.9	2.3	6.8	0.4	0.1	2.6
Leg fat-free mass (right)	1.9	10.3	17.1	2.1	-3.0	-4.1
Leg predicted mass (right)	1.9	10.2	17.1	2.1	-3.0	-4.1
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.3	1.4	-1.5	-1.8
Medication: Paracetamol	1.9	2.9	5.4	-1.8	0.6	-2.3
Alcohol drinker status: Never	1.9	2.2	5.3	-1.2	0.3	2.3
Pack years of smoking	1.9	2.7	4.9	-0.0	-2.2	-1.8
Breast Cancer	1.8	4.3	12.3	3.5	0.8	0.0
Lung FVC	1.8	9.0	20.4	4.5	-0.7	2.5
Heart attack	1.8	2.2	4.9	-2.2	-1.3	0.4
Prospective memory result	1.8	2.2	5.1	-1.2	-0.2	-2.3
Migraine (self-reported)	1.8	2.2	5.7	-0.4	2.4	0.8
Unable to work because of sickness or disability	1.8	2.4	5.5	0.6	-1.1	-2.4
Hypothyroidism (self reported)	1.7	4.0	11.4	3.4	-0.8	0.0
Trunk fat mass	1.7	7.2	16.4	0.5	-2.3	-4.0
Hair/balding pattern: Pattern 4	1.7	4.2	8.1	-1.3	-2.9	-1.6
Medication for pain relief, constipation, heartburn	1.7	2.9	4.7	2.2	0.2	2.0
Ever had bowel cancer screening	1.7	2.0	5.7	2.4	-0.5	0.2
Back pain experienced in last month	1.7	2.4	3.5	-1.8	-0.7	-1.9
Ever taken oral contraceptive pill	1.7	1.9	2.8	-1.7	1.6	-0.6
Basal metabolic rate	1.7	9.4	20.1	1.3	-2.5	-4.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.0	-2.2	-1.2	0.4
Worry (Nagel 2018)	1.6	3.4	9.3	-3.0	0.8	-0.4
Qualifications: CSEs or equivalent	1.6	2.1	2.8	-1.7	-1.4	-1.2
Worrier / anxious feelings	1.6	2.9	6.6	-2.6	1.5	-0.1
Standing height	1.6	16.4	28.8	3.7	-2.6	-5.4
Headache pain in last month	1.6	2.7	7.1	-2.7	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.7	-0.1	-1.9	-1.6
Whole body fat-free mass	1.6	9.0	18.5	1.6	-2.5	-4.3
Whole body water mass	1.6	9.2	18.9	1.5	-2.5	-4.3
Commuting to job workplace: Cycle	1.6	1.9	3.9	-1.3	0.3	2.0
Medication: Co-codamol	1.5	1.7	2.6	-1.6	-1.3	-0.9
Maternal smoking around birth	1.5	2.1	4.2	1.0	-2.0	-1.1
Medication: Atenolol	1.5	1.9	2.2	-1.5	-1.5	1.1
Trunk fat-free mass	1.5	8.3	17.8	1.4	-2.3	-4.2
Pulse rate	1.5	2.5	6.5	-0.5	2.6	0.8
Length of working week for main job	1.5	1.7	2.6	1.6	-0.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.3	1.4	-1.0	-1.5
Illnesses of siblings: Diabetes	1.5	1.8	2.6	-1.6	-0.7	-1.6
Diabetes diagnosed by doctor	1.5	2.5	4.0	-1.2	-1.4	-2.0
Age started oral contraceptive pill	1.5	1.8	3.3	1.4	0.6	1.8
Arm predicted mass (left)	1.5	7.7	17.0	1.2	-2.1	-4.1
Diabetes (mother)	1.4	1.8	4.7	-2.2	-0.8	-0.1
Waist circumference	1.4	5.3	12.1	-1.0	-1.6	-3.5
Falls in the last year	1.4	1.8	4.6	0.1	-1.0	-2.1
Trunk predicted mass	1.4	8.2	17.1	1.4	-2.3	-4.1
Breastfed as a baby	1.4	1.8	4.8	2.2	-0.6	0.5
Whole body fat mass	1.4	5.9	13.4	0.2	-2.1	-3.7
Arm predicted mass (right)	1.4	7.0	16.7	0.7	-1.9	-4.1
Long-standing illness, disability or infirmity	1.4	2.2	4.5	-1.4	-0.2	-2.1
Mineral and other dietary supplements	1.4	1.9	2.8	-1.5	0.9	1.7
Illnesses of father: None of the above (group 1)	1.4	1.8	5.0	-0.6	-2.2	-0.1
Arm fat-free mass (left)	1.4	7.2	15.4	1.2	-2.1	-3.9
Alcohol drinker status: Previous	1.4	1.5	4.4	-2.1	0.3	0.4
Leg fat mass (left)	1.4	5.3	12.2	-0.8	-1.7	-3.5
Diabetes (father)	1.3	1.6	3.9	-2.0	-0.7	-0.5
Supplements: Glucosamine	1.3	1.7	3.1	0.3	-1.8	-1.4
Financial difficulties in last 2 years	1.3	1.7	3.3	-1.8	1.3	-0.4
Happiness	1.3	1.5	2.8	-1.7	-0.2	-1.3
Loud music exposure frequency	1.3	1.4	3.4	-1.9	0.9	0.1
Medication: Ventolin 100micrograms inhaler	1.3	1.6	3.0	-1.7	1.1	0.9
Shortness of breath walking on level ground	1.3	1.6	3.8	-2.0	1.0	0.1
Leg fat mass (right)	1.3	5.1	11.4	-1.1	-1.6	-3.4
Overall health rating	1.3	2.7	5.2	-1.6	-0.5	-2.3
Cholesterol lowering medication	1.3	1.8	4.8	-0.3	-0.9	-2.2
Bipolar Disorder (2018)	1.2	2.0	4.3	-1.1	-0.6	-2.1
Ever had hysterectomy (womb removed)	1.2	1.3	3.3	-0.2	1.8	0.8
Trunk fat percentage	1.2	4.7	10.7	0.3	-1.8	-3.3
High blood pressure (mother)	1.2	1.6	3.7	-0.9	0.6	1.9
Diabetes (self-reported)	1.2	1.9	3.3	-0.5	-1.8	-1.5
Hip circumference	1.2	5.3	12.4	-0.3	-1.8	-3.5
Friendships satisfaction	1.2	1.5	2.1	-1.4	-1.5	-0.7
Arm fat mass (left)	1.2	5.0	10.3	0.5	-2.1	-3.2
Number of self-reported non-cancer illnesses	1.2	2.1	3.3	-1.7	-0.2	-1.8
High cholesterol (Self-reported)	1.2	2.1	3.6	-0.1	-1.7	-1.9
Medication: Atorvastatin	1.2	1.4	2.9	-1.7	-0.6	-1.0
Illnesses of father: High blood pressure	1.2	1.5	3.2	-1.1	1.8	0.4
Fractured/broken bones in last 5 years	1.2	1.5	2.6	1.6	1.1	0.8
Ulcerative Colitis (UC)	1.1	2.1	5.7	-2.4	0.4	-0.7
Fasting Glucose	1.1	1.4	4.0	-2.0	-0.3	0.0
Sensitivity / hurt feelings	1.1	1.8	5.0	-2.2	-0.3	-0.7
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.7	0.7	0.0	-1.9
Age when periods started (menarche)	1.1	2.7	4.5	1.9	-2.1	0.2
High blood pressure	1.1	3.0	5.1	-2.3	0.9	1.8
Arm fat mass (right)	1.1	4.5	9.4	0.4	-2.0	-3.1
Forced vital capacity (FVC), Best measure	1.1	3.9	10.2	3.2	-1.0	-0.6
Leg fat percentage (right)	1.1	3.8	5.8	-2.4	-0.6	-2.3
Arm fat-free mass (right)	1.1	5.9	14.6	0.7	-1.6	-3.8
Exposure to tobacco smoke outside home	1.1	1.5	2.3	-0.2	-1.5	-1.4
Eye problems/disorders: None of the above	1.1	1.2	3.1	-1.8	0.5	0.5
Pulse rate, automated reading	1.1	3.7	9.0	-0.6	3.0	1.3
Commuting to job workplace: Car/motor vehicle	1.1	1.3	1.6	1.3	-1.1	-1.0
Eye problems/disorders: Cataract	1.1	1.3	2.3	1.2	-0.6	-1.5
Hearing aid user	1.1	1.2	1.8	-1.4	1.1	0.7
Bipolar Disorder or Schizophrenia	1.0	2.3	3.7	-1.9	-0.0	-1.8
Depression (Nagel 2018)	1.0	1.5	2.0	-1.4	-1.1	-1.2
Reaction Time	1.0	1.9	5.2	-0.6	0.2	-2.3
Ulcerative Colitis	1.0	1.4	2.1	-1.3	0.6	-1.4
Systolic Blood Pressure	1.0	5.2	10.4	-3.2	0.7	2.2
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.2	-2.0	-0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.4	-0.2	-1.5	-2.1
Sitting height	1.0	7.0	11.6	2.1	-2.3	-3.4
Forced vital capacity (FVC)	1.0	4.0	11.4	3.4	-0.7	-0.3
Alcohol intake versus 10 years previously	1.0	1.4	4.3	-2.1	-0.2	-0.0
Medication: Cholesterol lowering	1.0	1.5	4.5	-0.2	-2.1	-0.2
Lung cancer (father)	1.0	1.2	2.3	1.5	-0.5	-1.0
Worry too long after embarrassment	1.0	1.7	4.1	-2.0	0.2	1.0
Number of children fathered	1.0	1.1	2.9	0.6	0.0	1.7
Comparative height size at age 10	1.0	5.5	12.3	1.6	-1.2	-3.5
Loneliness, isolation	1.0	1.4	2.4	-1.4	-1.5	-0.1
Diastolic blood pressure, automated reading	1.0	3.0	5.0	-0.6	2.2	1.9
Blood Platelet Count	0.9	10.6	17.0	-3.0	2.4	-4.1
Number of treatments/medications taken	0.9	1.6	2.4	-1.6	0.0	-1.5
Relative age voice broke	0.9	1.3	2.4	0.3	1.2	1.5
Had menopause	0.9	1.1	2.8	1.7	0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	2.4	-1.5	0.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.5	-0.0	0.9	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	1.6	-1.0	-1.2	-1.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.8	0.5	1.9	0.6
High blood pressure (siblings)	0.9	1.4	2.6	1.0	1.6	0.7
Body fat percentage	0.9	3.7	8.5	-0.3	-1.5	-2.9
Number of full brothers	0.9	1.1	2.0	1.4	-0.7	0.9
Medication: Blood pressure	0.9	1.6	3.0	-1.7	-1.3	-0.3
Hypertension (Self-reported)	0.9	2.6	4.5	-2.1	0.8	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.2	1.0	-0.7	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.2	2.3	-0.7	0.1
Guilty feelings	0.9	1.4	3.7	-1.9	-0.5	-0.5
Leg fat percentage (left)	0.9	3.1	5.2	-1.9	-0.6	-2.3
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.2	2.3	-0.2	-1.6
Irritable Bowel Disease (IBD)	0.8	1.9	3.7	-1.9	0.8	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.7	0.5	-0.0	2.4
Neuroticism (2016)	0.8	1.2	3.1	-1.8	0.0	-0.6
Schizophrenia (2014)	0.8	1.7	2.9	-1.5	-0.2	-1.7
Triglycerides	0.8	1.2	1.9	-1.4	-0.6	-1.2
Cardiovascular Disease	0.8	2.8	7.4	-2.7	0.9	0.3
Impedance of leg (right)	0.8	3.6	5.3	-2.3	2.2	0.7
Hearing difficulty/problems with background noise	0.8	1.2	2.2	-0.8	0.9	1.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	1.4	0.4	1.2
Peak expiratory flow (PEF)	0.8	1.9	3.1	1.8	-1.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.5	0.3	-1.6	-0.2
Medication: Seretide 50 evohaler	0.8	0.9	1.6	-1.2	0.2	-1.0
Number of full sisters	0.8	1.0	2.9	0.2	-1.7	0.4
Had major operations	0.8	1.0	1.4	1.0	-0.7	1.2
Family relationship satisfaction	0.8	1.0	1.9	-0.7	-1.4	-0.8
Qualifications: nursing, teaching	0.8	1.2	1.9	-0.4	1.3	1.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	0.5	-1.2	-0.9
Primary Biliary Cirrhosis	0.7	1.0	1.5	0.8	-1.2	-1.0
Rheumatoid Arthritis	0.7	1.0	2.4	-0.2	-0.8	-1.5
Hearing difficulty/problems: Yes	0.7	1.1	2.7	-0.4	1.6	0.7
Systolic blood pressure, automated reading	0.7	2.1	4.4	-1.4	0.2	2.1
Hand grip strength (right)	0.7	2.0	5.5	2.4	-0.6	-0.0
Body mass index (BMI)	0.7	3.0	6.0	-0.9	-1.5	-2.5
Past tobacco smoking	0.7	1.3	2.5	-1.1	-0.2	1.6
Arm fat percentage (right)	0.7	2.9	5.6	0.2	-1.8	-2.4
Father’s age at death	0.7	0.9	1.2	1.1	-0.7	-1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	-0.9	-0.6	-1.1
Supplements: Vitamin C	0.7	0.8	2.3	-0.1	-1.5	-0.2
Arm fat percentage (left)	0.7	2.8	5.4	-0.0	-1.7	-2.3
Eye problems/disorders: Glaucoma	0.7	0.8	2.0	0.6	-0.4	-1.4
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.6	1.1	0.6	1.9
Prostate Cancer	0.6	0.9	2.1	-0.6	-0.3	1.5
Age at First Birth	0.6	0.8	1.8	1.3	0.5	0.6
Lupus	0.6	0.9	1.6	-0.8	0.7	-1.3
Vitamin and mineral supplements	0.6	0.8	1.6	0.4	1.3	0.7
Allergy	0.6	1.3	1.4	1.2	-1.1	1.1
Medication: Ramipril	0.6	0.7	1.5	0.8	-1.2	-0.1
Noisy workplace	0.6	0.7	1.0	0.9	1.0	0.6
Qualifications: College or University degree	0.6	1.8	2.9	0.7	1.4	1.7
Heart disease (mother)	0.6	0.7	1.4	0.6	1.2	-0.6
Commuting to job workplace: Walk	0.6	0.7	1.6	0.0	1.3	-0.7
Schizophrenia (2018)	0.5	1.1	2.3	-1.5	0.6	-0.8
Blood Eosinophil Count	0.5	4.0	9.2	1.3	-1.1	-3.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.3	-1.1	0.4	-0.7
Impedance of leg (left)	0.5	2.6	5.1	-1.4	2.3	0.7
Medication: Simvastatin	0.5	0.8	1.6	-0.8	-1.3	-0.4
Fluid intelligence score	0.5	1.1	2.5	0.8	-0.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	-1.1	0.3	0.7
Blood clot in the leg (DVT)	0.5	0.6	1.1	1.0	-0.8	-0.1
Medication: Amlodipine	0.5	0.6	1.3	-1.1	-0.6	-0.5
Medication: Allopurinol	0.5	0.6	1.4	-0.7	1.2	-0.2
Alcohol intake frequency.	0.5	1.1	2.7	-1.6	-0.1	0.8
Suffer from ‘nerves’	0.5	0.8	1.9	-1.4	0.7	-0.2
Age at last live birth	0.5	0.8	1.8	-0.5	-1.3	0.5
Smoking status: Previous	0.5	0.7	1.6	0.6	0.6	-1.2
Average weekly red wine intake	0.5	0.8	1.6	0.3	0.8	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	1.2	0.2	0.2
Medication for cholesterol	0.5	0.7	1.6	0.5	-1.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	0.6	-1.1	-0.0
Mother’s age at death	0.5	0.6	1.4	0.5	0.0	-1.2
Commuting to job workplace: Public transport	0.5	0.6	0.9	0.5	1.0	0.7
Number of operations (self-reported)	0.5	0.7	1.9	1.4	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	0.1	-0.2	-1.4
Heart disease (siblings)	0.5	0.6	1.0	-1.0	0.2	0.8
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.1	-0.4	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	0.4	-0.7	-0.9
Crohns Disease (2017)	0.4	0.9	0.9	-0.9	1.0	-1.0
BMI	0.4	2.2	3.0	-1.3	-1.4	-1.7
Allergy or Eczema	0.4	1.0	2.8	-0.5	1.7	-0.0
Average weekly spirits intake	0.4	0.5	1.3	0.1	0.4	-1.1
Relative age of first facial hair	0.4	0.8	1.3	1.1	-0.3	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	-1.2	0.1	0.1
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.3	0.0	1.5	-0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	1.0	-0.7	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	-0.1	-0.2	-1.3
Qualifications: None of the above	0.4	0.8	1.7	-0.4	-0.8	-1.3
Exposure to tobacco smoke at home	0.4	0.4	0.7	-0.8	-0.2	-0.7
Pulse wave peak to peak time	0.4	0.4	0.9	0.6	0.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.9	-1.4	0.3	-0.2
Wears glasses or contact lenses	0.4	0.5	1.2	-1.1	-0.3	0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.6	-0.8	-0.4	0.8
Ever depressed for a whole week	0.4	0.5	1.4	-1.2	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	0.7	-1.0	-0.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-0.2	-0.4	0.9
LDL Cholesterol	0.3	0.4	0.9	0.9	-0.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	0.0	-0.2	-1.1
Heel T-Score	0.3	2.7	8.0	0.2	0.3	-2.8
Chronotype (morning person)	0.3	0.8	0.9	-0.7	-0.9	0.9
Hand grip strength (left)	0.3	0.9	2.0	1.4	-0.7	0.2
Supplements: Zinc	0.3	0.3	0.5	-0.4	-0.6	-0.7
Townsend deprivation index at recruitment	0.3	0.4	1.2	0.3	-0.1	-1.1
Alcohol usually taken with meals	0.3	0.5	1.0	0.8	0.2	1.0
Nervous feelings	0.3	0.6	1.4	-1.2	-0.3	-0.5
Illnesses of siblings	0.3	0.5	0.9	0.2	-0.7	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	-0.1	0.3	1.4
Illnesses of mother	0.3	0.3	0.6	0.6	-0.3	-0.8
Tense / ‘highly strung’	0.3	0.5	0.8	-0.5	-0.9	-0.6
Gout (self-reported)	0.3	0.4	0.7	-0.9	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	-1.1	-0.0	0.3
Comparative body size at age 10	0.3	0.8	1.3	0.5	-1.0	-1.1
Age at first live birth	0.3	0.6	1.7	0.2	-1.3	-0.0
Mean time to correctly identify matches	0.3	0.6	1.5	0.6	-0.0	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	0.4	-0.7	0.5
Medication: Aspirin	0.3	0.4	0.5	-0.6	-0.7	0.7
Ever smoked	0.3	0.6	0.9	0.9	0.1	-0.9
Blood White Count	0.2	1.3	2.4	1.6	-1.1	-0.6
Smoking Status	0.2	0.5	1.2	-0.5	-0.1	-1.1
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.1	0.6	-0.4
Current tobacco smoking	0.2	0.3	0.5	-0.5	-0.7	-0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.7	0.1	0.2
Had other major operations	0.2	0.2	0.5	0.7	-0.0	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	-0.4	-0.6	-0.9
Number of live births	0.2	0.3	0.6	0.4	0.5	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	-0.7	-0.9	-0.0
Birth weight of first child	0.2	0.3	0.9	0.1	0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	0.5	0.6	0.6
Glaucoma (self-reported)	0.2	0.3	0.5	0.7	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.8	0.3	0.2
Medication: Aspirin	0.2	0.2	0.3	-0.5	-0.4	0.5
Medication: Gliclazide	0.2	0.2	0.5	-0.1	-0.7	-0.3
Waist Hip Ratio (WHR)	0.1	0.3	0.9	-0.1	-0.1	-1.0
Medication: Metformin	0.1	0.1	0.1	-0.3	-0.3	0.3
Multivitamins +/- minerals	0.1	0.1	0.2	-0.2	-0.4	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.2	0.1	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	-0.3	-0.5
Impedance of arm (right)	0.1	0.5	1.2	1.1	-0.2	0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.3	-0.1	0.5
Impedance of arm (left)	0.1	0.5	1.3	1.1	0.0	0.4
Medication: Omeprazole	0.1	0.1	0.1	-0.2	0.3	-0.3
Illnesses of father: Heart disease	0.1	0.2	0.4	0.2	0.6	0.3
Breast cancer (self-reported)	0.1	0.1	0.2	0.3	-0.1	0.5
Smoking status: Current	0.1	0.2	0.3	-0.4	-0.5	-0.3
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.0	-0.7	-0.2
Risk taking	0.1	0.1	0.3	-0.1	-0.0	-0.5
Myopia	0.1	0.1	0.3	-0.5	-0.1	0.4
Impedance of whole body	0.1	0.5	1.0	-0.0	1.0	0.6
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Pain all over the body in last month	0.0	0.0	0.1	-0.1	-0.3	0.0
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.0	-0.3	-0.2
Birth weight	0.0	0.1	0.1	-0.3	-0.2	0.3
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	0.0	0.1	0.4

Hub : Genes

MVD

Models

Trait associations