TWAS hub - CYBA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.5280	0.1070	3.4e-04	0.011	NA	0.081	NA	0.006	1.7e-01	NA	5.9e-03	NA	2.3e-01
2	GTEx	Pancreas	0.2850	0.0770	1.2e-04	0.318	NA	0.286	NA	0.313	5.1e-14	NA	1.5e-12	NA	8.7e-14
3	NTR	Blood	0.0485	0.0148	2.6e-06	0.043	0.024	0.048	0.040	0.048	1.0e-13	2.4e-08	4.3e-15	5.9e-13	4.1e-15
4	YFS	Blood	0.3423	0.0347	0.0e+00	0.108	0.193	0.203	0.198	0.172	1.5e-33	5.5e-61	2.2e-64	1.3e-62	9.6e-54
5	TCGA	Cervical Squamous Cell Carcinoma	0.0910	0.0430	2.9e-03	0.057	0.073	0.069	NA	0.071	9.0e-04	1.8e-04	2.6e-04	NA	2.3e-04
6	TCGA	Lung Adenocarcinoma	0.0572	0.0260	1.5e-03	-0.002	0.010	0.009	NA	-0.002	5.9e-01	1.9e-02	2.8e-02	NA	6.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hair Pigment	8.3	236.6	605.2	-24.6	-6.0	13.3	-7.8	-8.0	-21.8
Tanning	8.3	101.7	204.5	14.3	6.9	-10.6	2.6	7.7	13.4
Osteoporosis (self-reported)	3.7	4.5	9.1	0.8	1.4	-3.0	0.5	2.6	2.9
Number of incorrect matches in round	3.4	5.7	11.0	0.5	2.4	-3.3	-0.4	2.5	3.3
Deep venous thrombosis (DVT) (self-reported)	3.0	3.8	6.7	2.3	0.3	-2.6	-1.2	2.5	1.8
Neck or shoulder pain in last month	2.9	4.1	8.9	-0.9	0.9	-3.0	-2.6	1.8	1.9
Handedness (chirality/laterality): Left-handed	2.9	3.5	7.8	1.4	2.8	-0.5	2.5	0.9	2.0
Average weekly beer plus cider intake	2.9	4.2	11.9	-0.8	3.4	-0.4	3.2	-1.3	-0.9
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	10.4	-0.4	-3.2	0.9	-2.3	-0.5	-1.3
Medication: Lansoprazole	2.8	3.2	6.9	0.1	1.3	-1.8	-1.5	2.6	2.2
Financial situation satisfaction	2.8	3.5	6.4	0.3	-0.5	2.2	2.5	-1.8	-2.5
Blood clot in the leg (DVT)	2.7	3.5	6.3	2.1	0.3	-2.5	-1.1	2.5	1.7
Pulse rate, automated reading	2.6	8.4	18.4	-2.3	-2.1	2.9	2.5	-4.3	-2.7
Osteoarthritis (self-reported)	2.6	3.3	6.1	0.9	2.1	-1.5	-0.7	2.5	2.4
Unable to work because of sickness or disability	2.5	3.3	7.6	0.3	0.5	-2.8	-2.5	1.7	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	5.2	2.3	1.4	-1.6	0.6	1.5	2.2
Ever taken oral contraceptive pill	2.3	2.6	5.9	-1.7	2.0	1.1	-1.0	-2.4	-1.0
Commuting to job workplace: Public transport	2.3	2.7	5.8	-1.8	-1.5	1.2	-0.7	-2.4	-1.7
Relative age voice broke	2.1	3.3	8.7	-1.5	-3.0	0.8	-0.5	-0.7	-2.7
Emphysema/chronic bronchitis	2.1	2.3	5.7	0.5	0.5	-2.4	-0.9	2.1	1.6
Leg pain on walking	2.1	2.6	7.3	0.4	0.1	-0.9	-1.6	2.2	2.7
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.1	2.3	1.5	-0.8	-0.4	2.1	1.7
HbA1C	2.0	2.3	5.6	0.3	2.3	-2.4	-0.7	1.1	0.9
Pulse rate	2.0	3.4	8.1	-0.7	-2.0	1.3	1.3	-2.8	-2.0
Medication: Bendroflumethiazide	2.0	3.0	6.4	-2.4	1.1	1.2	1.8	-2.5	-0.2
Medication: Atorvastatin	2.0	2.4	4.4	1.7	1.0	-1.6	1.0	2.1	1.7
Neuroticism (2016)	1.9	2.7	12.4	-3.5	-0.5	-1.0	-0.6	-1.0	-1.2
Knee pain experienced in last month	1.9	3.0	6.1	0.9	1.1	-2.5	-2.4	1.4	1.5
Leg fat-free mass (right)	1.9	10.2	34.0	5.8	-0.7	-1.7	-1.7	3.1	3.3
Leg predicted mass (right)	1.9	10.2	34.3	5.9	-0.8	-1.8	-1.7	3.1	3.3
Hearing aid user	1.9	2.2	9.5	-3.1	-0.7	1.0	0.2	-1.2	-0.6
Pain experienced in last month	1.9	3.2	8.6	0.8	-2.9	2.2	1.6	-0.9	-1.4
Ovarian Cancer	1.8	2.4	6.1	-2.5	2.2	1.3	-0.7	-1.1	-0.7
Impedance of leg (right)	1.8	8.7	25.5	-5.0	0.7	2.4	1.1	-4.2	-1.3
Supplements: Fish oil (including cod liver oil)	1.8	2.3	8.3	-0.5	1.1	-2.0	-0.2	2.9	0.3
High cholesterol (Self-reported)	1.8	3.2	8.5	0.3	2.9	-1.4	0.1	1.8	2.3
Leg fat-free mass (left)	1.7	9.1	29.3	5.4	-0.7	-1.5	-1.6	2.9	3.4
Maternal smoking around birth	1.7	2.4	5.9	0.4	1.6	-2.4	-0.1	1.7	1.7
Taking other prescription medications	1.7	2.7	5.2	0.5	1.3	-1.8	-1.3	2.3	2.0
Suffer from ‘nerves’	1.7	2.7	7.2	-1.9	-0.5	0.9	-1.0	-2.7	-1.7
Supplements: Vitamin C	1.7	2.1	4.4	1.2	1.8	-1.4	-0.7	1.0	2.1
Mean Putamen Volume	1.6	1.8	4.2	-2.1	-1.0	-1.0	-1.5	0.7	1.4
Medication: Levothyroxine sodium	1.6	2.8	7.3	1.8	-0.3	-2.4	-2.7	0.5	0.1
Leg predicted mass (left)	1.6	8.7	28.6	5.3	-0.7	-1.5	-1.6	2.8	3.3
Number of full brothers	1.6	2.0	5.3	0.5	1.9	-0.2	1.7	0.4	2.3
Number of children fathered	1.6	1.8	5.8	1.3	1.4	-0.0	0.6	1.0	2.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	10.0	3.2	0.4	-1.9	-1.2	2.3	0.7
Impedance of leg (left)	1.5	7.3	22.8	-4.8	0.8	1.9	0.7	-3.8	-1.3
Alcohol usually taken with meals	1.5	2.5	9.6	0.2	-3.1	1.4	-0.2	-0.5	-1.7
Diabetes (self-reported)	1.5	2.3	8.8	0.8	-3.0	-1.0	-1.7	0.9	0.2
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.0	0.1	-0.7	-1.8	-1.0	1.6	2.0
Pack years of smoking	1.5	2.2	5.8	1.4	1.8	-0.6	0.9	1.2	2.4
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.2	0.1	1.6	1.0	1.3	0.8	1.8
Birth weight of first child	1.4	2.5	4.2	0.0	-1.7	1.1	-1.9	-2.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.6	-1.8	-0.1	1.9	0.0	-1.2	-0.9
Medication: Blood pressure	1.4	2.6	4.5	-2.0	-1.6	0.3	0.9	-1.9	-2.1
Pack years adult smoking proportion	1.3	1.9	4.4	1.2	1.6	-0.9	0.7	1.4	2.1
Qualifications: CSEs or equivalent	1.3	1.7	4.7	0.3	-0.0	-2.2	-1.2	1.9	0.0
Stomach or abdominal pain in last month	1.3	1.7	3.6	-1.9	1.0	-1.1	-1.9	0.0	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.8	-0.2	-1.3	1.6	-0.4	-1.7	-1.1
Medication: Cholesterol lowering	1.3	2.0	4.3	0.9	1.6	-1.2	0.3	1.7	2.1
Angina (self-reported)	1.3	1.7	4.6	0.1	0.5	-1.1	0.1	2.1	1.9
Overall health rating	1.3	2.7	7.1	-1.7	0.7	-1.9	-2.7	1.0	0.9
Whole body fat-free mass	1.3	7.3	24.4	4.9	-0.4	-1.4	-2.0	2.2	2.9
Whole body water mass	1.3	7.2	24.2	4.9	-0.3	-1.5	-1.9	2.2	2.9
Miserableness	1.3	2.2	4.9	-1.6	-1.4	0.4	0.7	-1.7	-2.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.0	-0.4	1.3	-1.3	-0.2	1.5	2.0
Worry (Nagel 2018)	1.2	2.6	9.0	-3.0	-0.4	-0.2	-0.9	-1.4	-1.8
Primary Biliary Cirrhosis	1.2	1.8	8.1	2.9	0.2	-0.8	-0.4	1.0	0.8
Respiratory disease	1.2	2.7	8.7	-3.0	-0.5	1.7	0.0	-1.6	-1.3
Relative age of first facial hair	1.2	2.6	8.2	-1.3	-1.7	0.6	-2.9	1.1	-1.0
Angina	1.2	1.6	5.3	0.3	0.2	-1.0	-0.0	2.3	1.8
Serious illness, injury or assault to yourself	1.2	1.4	5.4	-0.8	-2.3	-0.6	-1.1	-0.5	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.9	10.0	3.2	0.7	-2.1	-0.6	1.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.2	-1.5	-0.6	-0.5	0.0	-1.1	-2.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	5.1	2.3	-0.2	-2.2	-2.1	0.1	-0.4
Number of full sisters	1.2	1.5	4.0	0.7	2.0	-0.7	-0.2	0.4	1.9
Average weekly red wine intake	1.2	1.7	4.5	0.2	-1.8	0.6	-0.4	-1.4	-2.1
Illnesses of father: None of the above (group 1)	1.2	1.5	3.7	0.2	1.8	-1.5	-0.2	0.1	1.9
Basal metabolic rate	1.2	6.9	22.3	4.7	-0.3	-1.4	-1.9	2.1	3.0
Height	1.1	22.1	51.3	7.2	-1.3	-2.7	-5.5	2.7	5.9
Diabetes (father)	1.1	1.3	3.1	1.8	0.7	-1.0	-0.7	1.3	1.0
Diabetes (mother)	1.1	1.4	4.1	-2.0	-1.7	1.1	0.2	0.0	0.2
Sitting height	1.1	8.1	23.9	4.9	-0.3	-1.9	-2.5	2.2	3.1
Heart attack	1.1	1.4	2.7	0.3	1.1	-0.6	1.5	1.3	1.6
Weight	1.1	5.6	13.9	3.7	0.2	-1.3	-0.9	2.3	3.4
Trunk predicted mass	1.1	6.0	19.3	4.4	-0.2	-1.2	-2.2	1.7	2.7
Medication: Ibuprofen	1.1	1.3	3.2	-1.8	-0.4	0.1	0.6	-1.4	-1.4
Medication: Seretide 50 evohaler	1.1	1.3	3.0	1.2	1.3	0.0	0.6	1.7	1.1
Family relationship satisfaction	1.1	1.4	4.6	-1.6	-2.1	0.7	0.8	0.2	0.0
Illnesses of siblings: Diabetes	1.1	1.4	3.2	-1.4	-0.3	-1.4	-1.8	0.8	0.7
Diabetes diagnosed by doctor	1.1	1.8	8.4	-0.0	-2.9	-0.7	-1.4	0.3	0.3
Medication for cholesterol	1.1	1.6	5.2	2.3	0.2	0.4	0.6	1.6	1.2
Arm fat-free mass (left)	1.1	5.4	18.8	4.3	0.4	-1.4	-1.5	1.5	2.6
Arm predicted mass (left)	1.1	5.6	18.9	4.3	0.5	-1.4	-1.5	1.6	2.7
LDL Cholesterol	1.0	1.5	2.9	1.7	1.7	0.6	0.7	1.1	1.1
Blood Red Count	1.0	10.0	53.1	7.3	0.9	-1.0	2.0	-0.2	-0.7
Type 2 Diabetes (T2D) (2018)	1.0	1.8	8.1	0.5	-2.8	-0.5	-1.5	0.0	-0.4
Neuroticism	1.0	2.5	11.4	-3.4	-0.8	-0.6	0.3	-1.2	-1.0
Hearing difficulty/problems: Yes	1.0	1.5	2.3	-1.5	1.0	0.9	-1.0	-1.4	-1.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.8	-1.6	-0.5	-0.4	-2.2	-0.1	-0.1
Neuroticism score	1.0	2.0	6.9	-2.6	-0.3	-0.4	-0.2	-1.8	-1.1
Trunk fat-free mass	1.0	6.0	18.9	4.3	-0.3	-1.3	-2.3	1.7	2.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	8.7	3.0	-0.7	-1.4	-1.8	2.0	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	7.6	2.3	-1.4	-0.6	-2.7	1.8	0.9
Glaucoma (self-reported)	1.0	1.2	4.2	-0.5	-2.0	-0.3	-1.2	-0.0	-1.3
Wheeze or whistling in the chest in last year	1.0	1.8	3.0	-1.3	0.9	1.7	1.3	-1.2	-1.3
Tinnitus: Yes, now most or all of the time	1.0	1.1	5.0	0.7	-0.7	-0.1	2.2	0.8	-0.3
Alcohol drinker status: Previous	1.0	1.1	4.7	-0.4	0.3	1.4	2.2	-0.1	-0.1
Schizophrenia (2018)	0.9	2.0	3.7	0.0	-1.1	1.4	-1.9	-1.5	-1.6
Alzheimer’s Disease (in mother)	0.9	1.0	3.1	1.8	-0.9	0.9	-0.1	1.0	0.8
Supplements: Glucosamine	0.9	1.2	2.6	-1.2	-1.1	-1.1	-0.7	1.6	0.1
Chronic bronchitis/emphysema (father)	0.9	1.0	4.2	0.4	0.2	1.0	2.1	0.3	-0.8
Trunk fat mass	0.9	3.8	11.5	2.5	0.3	-1.4	-0.2	1.7	3.4
Time employed in main current job	0.9	1.1	3.4	0.1	-0.7	-0.2	-0.5	1.5	1.8
Exposure to tobacco smoke outside home	0.9	1.1	2.7	0.7	1.6	-1.4	0.0	0.5	1.1
Heart disease (mother)	0.9	1.1	5.5	-2.3	0.4	-0.6	-0.3	-0.1	-0.6
Arm predicted mass (right)	0.9	4.6	17.6	4.2	-0.6	-0.8	-1.7	1.3	2.1
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.4	0.8	0.2	-0.6	-1.1	1.8	1.0
Long-standing illness, disability or infirmity	0.9	1.4	4.4	-0.2	-1.0	-0.9	-2.1	1.0	1.1
Number of self-reported non-cancer illnesses	0.9	1.6	4.3	-2.1	1.1	-1.2	-1.2	0.7	0.7
Guilty feelings	0.9	1.3	3.0	-1.4	0.6	0.4	1.4	-1.7	-0.7
Rheumatoid Arthritis	0.8	1.1	4.1	-2.0	1.1	0.0	-0.5	0.6	1.0
Triglycerides	0.8	1.3	2.9	0.7	1.5	-0.8	1.2	0.5	1.7
Blood White Count	0.8	5.6	25.2	5.0	-0.0	-1.1	1.1	1.5	1.9
Cardiovascular Disease	0.8	2.5	6.4	-1.9	0.9	1.9	0.8	-2.5	-0.3
Hypothyroidism (self reported)	0.8	1.9	4.2	2.0	0.0	-2.0	-1.7	0.0	-0.2
Chronotype (morning person)	0.8	1.9	9.7	-0.7	-0.4	0.6	3.1	0.3	0.9
Hand grip strength (left)	0.8	2.1	5.1	2.2	-1.6	-0.6	-2.3	0.4	-0.1
Average weekly spirits intake	0.8	1.0	2.9	-0.1	-0.7	-0.0	-1.2	-1.7	-1.1
Medication for hormone replacement therapy	0.8	0.9	2.2	-1.0	1.5	-0.9	-0.6	-1.1	-0.1
Hand grip strength (right)	0.8	2.1	5.6	2.0	-1.7	-0.1	-2.4	0.1	-0.2
Average weekly fortified wine intake	0.8	0.9	2.0	-0.3	-0.4	-1.1	-0.8	-1.2	-1.4
Age when periods started (menarche)	0.8	2.0	4.9	1.5	-0.6	-1.1	-0.3	2.2	1.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.4	0.5	1.8	0.4	-1.2	-0.5	-0.7
Illnesses of mother	0.8	1.0	4.4	2.1	-0.1	-0.7	-0.1	0.9	0.4
Arm fat mass (right)	0.8	3.3	7.1	2.7	0.9	-1.4	-0.1	1.8	2.6
Length of working week for main job	0.8	0.9	3.1	0.7	0.6	-0.7	0.6	0.6	1.8
Arm fat-free mass (right)	0.8	4.4	17.6	4.2	-0.6	-0.9	-1.4	1.1	2.1
Worry too long after embarrassment	0.8	1.4	3.9	-0.6	0.7	0.5	1.7	-2.0	-0.5
Health satisfaction	0.8	1.0	2.8	0.8	-0.4	-1.1	-0.8	0.9	1.7
Whole body fat mass	0.8	3.3	9.7	2.5	0.7	-0.9	-0.0	1.6	3.1
Mineral and other dietary supplements	0.8	1.1	3.7	1.0	-0.2	1.2	0.5	-1.9	-0.1
Medication: Gliclazide	0.8	0.9	4.2	0.7	-2.0	0.1	-0.8	0.6	-0.2
Arm fat mass (left)	0.8	3.5	8.6	2.9	0.7	-1.1	-0.1	1.9	2.6
Average weekly champagne plus white wine intake	0.8	1.1	2.1	1.4	-1.5	-0.7	-0.5	0.9	-0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.5	0.2	0.9	-0.2	1.6	0.9	1.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.7	-1.9	-0.2	-1.2	1.4	0.8	-0.7
Alzheimer’s Disease (including proxy)	0.7	1.1	2.5	1.6	-0.8	-0.2	-0.6	1.4	1.0
Breast Cancer	0.7	1.6	5.7	-0.4	-0.7	1.1	-1.4	-0.6	-2.4
Age at First Birth	0.7	1.0	2.8	-0.8	-0.9	1.7	0.4	-0.5	-1.1
Medication: Metformin	0.7	1.0	3.8	0.5	-1.9	-0.6	-1.2	-0.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	3.2	-0.5	-1.8	-0.9	-0.3	0.7	-0.5
High blood pressure	0.7	1.8	3.7	-1.7	-0.4	1.6	1.3	-1.9	-0.1
High blood pressure (mother)	0.7	0.9	2.4	-0.7	1.5	0.1	-0.7	-1.3	-0.6
Hair/balding pattern: Pattern 2	0.7	0.9	3.4	0.1	1.8	-0.8	-0.9	0.4	0.4
Financial difficulties in last 2 years	0.7	0.9	3.1	-1.1	0.9	-0.1	1.8	-0.5	-0.5
Arm fat percentage (right)	0.7	2.8	6.4	1.7	1.4	-1.2	0.8	1.9	2.5
Hip circumference	0.7	3.1	6.9	2.1	0.7	-1.6	-0.1	2.1	2.6
Worrier / anxious feelings	0.7	1.3	2.9	-1.5	-0.3	0.3	-0.2	-1.7	-1.6
Hair/balding pattern: Pattern 4	0.7	1.6	3.1	-1.4	0.8	-1.4	-0.1	1.4	1.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.2	-0.3	-1.0	-0.5	-0.7	-0.7	-2.1
Eye problems/disorders: None of the above	0.7	0.8	1.9	0.5	1.4	-0.9	0.9	0.9	0.3
Medication for pain relief, constipation, heartburn	0.7	1.1	3.2	-0.0	-0.8	1.8	0.8	-1.5	-0.5
Migraine (self-reported)	0.7	0.9	1.8	0.4	0.6	0.2	-1.3	-1.1	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.4	-0.3	-0.6	-0.1	-0.2	1.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.8	1.6	-1.7	1.2	-1.5	-0.4	0.2
Commuting to job workplace: Walk	0.7	0.7	2.5	0.1	-0.0	0.5	0.4	-1.3	-1.6
Back pain experienced in last month	0.7	1.0	3.1	-1.1	0.3	1.0	-1.8	-0.8	0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.1	-1.4	-0.0	-0.1	0.7	1.0	1.2
Diastolic blood pressure, automated reading	0.7	2.2	5.7	-1.9	-0.2	0.9	1.0	-2.4	-1.4
Commuting to job workplace: Cycle	0.7	0.8	3.0	-0.2	-1.7	0.4	0.9	-0.7	-0.6
Myopia	0.7	1.0	2.7	0.5	-1.6	1.2	0.1	-1.1	-0.9
Cholesterol lowering medication	0.7	1.1	2.5	-1.0	0.1	-1.0	-1.6	0.9	1.0
Bipolar Disorder (2018)	0.6	0.9	4.2	-0.6	-0.8	-2.0	-0.2	0.7	0.1
Neuroticism (Nagel 2018)	0.6	1.5	6.9	-2.6	-0.1	-0.0	0.8	-0.3	-1.2
Alzheimer’s Disease (in father)	0.6	0.7	3.1	-0.4	-1.8	0.7	0.1	0.7	0.2
Reaction Time	0.6	1.1	4.1	-2.0	0.3	0.3	-0.2	-1.2	0.9
Lung FEV1/FVC ratio	0.6	3.2	8.1	1.6	-1.2	-2.1	0.0	1.6	2.8
Trunk fat percentage	0.6	2.5	8.8	1.4	0.6	-1.2	0.5	1.4	3.0
Fed-up feelings	0.6	1.0	3.2	-0.3	0.5	-1.8	0.0	1.6	0.1
Body mass index (BMI)	0.6	2.7	5.8	2.4	1.0	-1.0	0.3	2.0	2.0
Forced vital capacity (FVC)	0.6	2.3	6.8	2.6	-0.4	-1.1	-1.8	1.2	0.8
Qualifications: None of the above	0.6	1.3	2.6	1.0	1.2	-1.6	-1.1	1.1	0.1
Mouth/teeth dental problems	0.6	0.9	4.1	0.1	-0.2	0.4	2.0	-0.3	-0.9
Alcohol intake versus 10 years previously	0.6	0.8	3.1	-0.0	0.9	-0.5	-1.8	-0.4	0.8
Father’s age at death	0.6	0.8	2.6	0.3	-0.8	1.6	-0.2	-1.1	-0.3
Noisy workplace	0.6	0.7	2.6	-0.4	-0.0	1.6	-0.1	-1.1	-0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	3.6	-0.3	-0.8	-1.0	-1.9	0.9	0.1
Prospective memory result	0.6	0.7	3.3	-0.4	0.6	-0.2	0.7	-0.3	1.8
Standing height	0.6	6.4	12.7	3.6	-1.7	-1.1	-3.1	1.1	3.3
Medication: Amlodipine	0.6	0.8	2.3	-1.3	-0.2	-1.5	-0.0	0.0	0.8
High blood pressure (siblings)	0.6	0.9	2.7	0.5	1.6	1.3	0.2	-0.5	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.3	5.4	2.1	-1.0	-0.4	-2.3	1.5	0.7
Comparative body size at age 10	0.6	1.6	3.3	1.6	0.9	-1.1	1.1	1.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	-0.1	-1.3	0.6	-0.1	0.9	1.4
Qualifications: College or University degree	0.6	2.0	7.7	-0.4	-0.9	2.8	-0.7	-1.5	-0.8
Leg fat mass (right)	0.6	2.2	7.0	2.1	0.9	-0.3	0.3	1.0	2.6
Chest pain or discomfort	0.6	0.8	1.3	-0.2	1.0	-1.1	0.7	1.1	1.0
Medication: Aspirin	0.6	0.7	2.2	1.5	-1.0	-0.5	-0.6	0.5	-0.6
Hypertension (Self-reported)	0.6	1.7	3.7	-1.9	-0.8	1.2	1.4	-1.6	-0.1
Arm fat percentage (left)	0.6	2.2	5.8	1.7	0.7	-0.7	0.9	1.7	2.4
Loneliness, isolation	0.6	0.8	2.1	-1.4	1.4	-0.1	0.8	-0.6	-0.1
Friendships satisfaction	0.6	0.8	2.5	0.8	-0.1	-0.2	-0.1	1.6	1.2
Smoking status: Current	0.6	1.0	1.6	-1.3	-0.2	-0.9	-1.2	-1.0	-1.0
Eye problems/disorders: Glaucoma	0.6	0.7	2.2	-0.7	-1.2	-0.4	-1.5	0.1	-0.4
Ever smoked	0.6	1.0	2.4	0.4	0.9	0.9	0.0	-1.3	-1.6
Risk taking	0.6	0.9	3.6	-0.8	0.4	0.9	-0.1	-1.9	-0.5
Ever depressed for a whole week	0.6	0.7	2.3	1.5	0.2	0.3	0.7	-0.8	-0.9
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.7	1.5	0.6	-1.2	-1.6	1.6	-0.2
Impedance of whole body	0.6	3.1	12.2	-3.5	-0.4	1.2	0.7	-2.1	-0.5
Leg fat mass (left)	0.6	2.4	7.6	2.2	1.0	-0.5	0.1	1.1	2.8
Bipolar Disorder or Schizophrenia	0.5	1.1	2.4	0.0	-1.3	-0.3	-1.6	-0.9	-1.2
Prostate Cancer	0.5	0.7	2.5	0.6	-0.7	1.6	0.8	-0.3	-0.3
Heel T-Score	0.5	3.6	14.5	3.8	-0.9	-1.4	-1.8	0.8	0.5
Supplements: Zinc	0.5	0.5	2.1	0.2	-1.4	0.8	-0.5	-0.1	-0.0
Current tobacco smoking	0.5	0.9	1.8	-1.4	0.1	-1.1	-1.3	-0.7	-0.5
Medication: Simvastatin	0.5	0.7	1.3	-0.6	0.9	-0.6	-0.9	0.8	1.1
Number of live births	0.5	0.7	2.4	0.0	-0.1	-1.6	0.0	1.3	0.4
Asthma	0.5	0.9	2.0	-1.2	0.7	1.1	1.4	-0.6	0.2
Depression (self-reported)	0.5	0.6	2.6	-1.6	0.2	-0.6	-0.2	-0.1	0.7
Exposure to tobacco smoke at home	0.5	0.6	2.0	0.7	-0.1	0.3	0.5	-0.7	1.4
Peak expiratory flow (PEF)	0.5	1.3	4.1	2.0	-1.1	0.4	-1.2	0.8	-0.0
Gout (self-reported)	0.5	0.6	2.4	0.4	-0.2	1.6	-0.3	-0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.5	-0.5	0.7	0.2	1.0	-0.9	-1.2
Body fat percentage	0.5	1.9	7.3	0.9	0.9	-0.8	0.7	1.1	2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.8	-0.2	-0.0	-0.4	0.3	1.1	1.4
Alcohol intake frequency.	0.5	1.1	3.9	0.9	0.1	0.3	0.2	2.0	1.4
Ever had bowel cancer screening	0.5	0.5	1.6	0.1	-0.0	1.3	-1.1	-0.3	0.4
Medication: Aspirin	0.5	0.7	2.9	1.7	-0.8	-0.3	-0.4	0.3	-0.3
Medication: Lisinopril	0.5	0.7	1.9	-1.4	0.5	-0.1	0.3	-0.8	-1.1
Alcohol drinker status: Never	0.5	0.6	1.7	0.7	-1.3	1.2	0.2	-0.2	0.0
Number of operations (self-reported)	0.5	0.8	2.2	0.7	1.5	-0.7	0.7	0.8	0.6
Fractured/broken bones in last 5 years	0.5	0.7	1.3	0.8	-0.8	0.9	-0.1	-0.6	-1.1
Blood Platelet Count	0.4	4.4	11.3	3.4	0.3	2.2	-0.8	-2.8	1.3
BMI	0.4	2.0	4.4	2.1	0.8	-1.1	1.0	1.5	1.7
Vitamin and mineral supplements	0.4	0.5	1.4	0.8	-0.2	0.5	-0.3	-0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-0.8	-0.2	-0.6	-0.9	0.7	1.1
Multivitamins +/- minerals	0.4	0.5	1.4	-1.0	-0.4	0.6	1.2	-0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.2	0.8	-1.5	0.0	-0.5	-0.0	-0.0
Waist circumference	0.4	1.6	3.9	1.8	0.3	-0.8	1.0	0.9	2.0
Nervous feelings	0.4	0.8	2.8	-1.7	0.0	-0.8	0.2	-1.1	0.2
Hearing difficulty/problems with background noise	0.4	0.7	1.6	0.9	1.3	-1.0	-0.2	0.6	-0.5
Had other major operations	0.4	0.4	1.3	0.2	1.1	-0.5	0.8	0.3	0.5
Medication: Ramipril	0.4	0.5	1.6	0.3	0.3	0.1	1.1	-0.2	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.3	1.5	0.4	0.1	-0.3	-0.9	-0.8
Lung cancer (father)	0.4	0.5	1.0	0.8	0.3	1.0	0.8	-0.5	-0.4
Breastfed as a baby	0.4	0.6	1.4	1.2	-1.1	0.5	0.5	-0.3	0.4
Tense / ‘highly strung’	0.4	0.7	1.3	-1.1	-0.6	0.1	-0.9	-1.1	-0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	-0.1	1.0	0.8	-1.2	-0.5	0.1
Medication: Paracetamol	0.4	0.7	2.1	-1.3	0.4	-0.3	-1.4	0.4	-0.0
Headache pain in last month	0.4	0.6	1.3	-0.9	-0.5	-0.8	-1.1	0.7	0.5
Age at first live birth	0.4	0.7	1.2	-0.4	-1.0	-0.0	-1.1	1.0	1.1
Medication: Allopurinol	0.4	0.5	1.1	1.1	0.1	0.9	-0.0	-0.0	-1.0
Mean time to correctly identify matches	0.4	0.7	2.2	-1.5	-0.0	0.8	-0.2	-0.8	0.8
Age at last live birth	0.4	0.5	1.5	-0.1	-1.2	-0.2	-0.5	1.0	0.7
Eye problems/disorders: Cataract	0.4	0.5	2.4	0.6	-0.3	1.6	-0.3	-0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	0.3	1.0	0.7	-0.1	-0.4	1.3
Mother’s age at death	0.4	0.5	1.2	0.5	-0.7	-0.3	-0.6	0.8	-1.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.7	0.1	-0.6	1.3	1.3	-0.2	-1.2
Schizophrenia vs Biploar Disorder	0.3	0.5	1.8	0.0	0.0	0.0	0.0	-0.9	-1.4
Ulcerative Colitis (UC)	0.3	0.6	3.0	-1.7	-0.7	0.2	-0.1	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.2	-0.2	-0.6	0.6	1.5	0.6	-1.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.8	0.0	0.0	0.0	0.0	-1.3	-0.1
Ulcerative Colitis	0.3	0.4	1.9	0.0	-1.4	0.3	-0.5	0.4	0.3
Blood Eosinophil Count	0.3	2.5	6.1	0.8	2.5	-0.2	-1.6	1.5	1.8
Smoking Status	0.3	0.8	3.0	-0.2	1.7	-0.7	-0.6	-0.5	-0.9
Allergy or Eczema	0.3	0.8	2.6	-0.2	0.7	1.1	-0.4	-0.7	-1.6
Sensitivity / hurt feelings	0.3	0.5	1.8	-1.2	-1.3	-0.3	0.0	0.0	-0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.2	0.9	-1.0	0.1	-0.2	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	-0.4	0.2	-0.6	-0.0	-0.8	-0.7
Medication: Co-codamol	0.3	0.3	0.8	-0.1	0.4	-0.3	-0.4	0.9	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.7	0.1	1.3	-0.7	-0.7	0.4	-1.2
Medication: Atenolol	0.3	0.4	1.6	-0.2	-0.2	0.2	-0.5	0.6	1.3
Past tobacco smoking	0.3	0.5	1.4	-0.6	-1.2	-0.6	0.2	0.1	1.0
Had menopause	0.3	0.3	1.0	0.2	1.0	0.1	0.6	0.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	-0.4	-0.1	-0.8	-0.8	-0.4	-0.6
Pain all over the body in last month	0.3	0.3	1.0	1.0	0.3	-0.5	0.1	0.7	0.3
Fluid intelligence score	0.3	0.6	1.6	-0.6	-0.9	-0.3	0.6	0.5	-1.3
Falls in the last year	0.3	0.4	1.6	-0.6	0.2	0.8	0.0	0.0	1.3
Impedance of arm (left)	0.3	1.4	4.5	-2.1	-1.4	1.0	0.7	-0.7	0.2
Pulse wave reflection index	0.3	0.4	1.0	1.0	0.2	0.3	-0.1	-0.6	-0.9
Medication: Blood pressure	0.3	0.5	1.4	0.1	-0.3	0.7	-0.3	0.8	1.2
Medication: Omeprazole	0.3	0.4	1.1	-0.3	1.0	-0.2	0.0	0.6	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	1.1	0.4	-0.0	-0.5	0.6	-0.4
Illnesses of father: Heart disease	0.3	0.4	1.1	0.2	-0.4	0.9	0.3	1.0	-0.2
Smoking status: Previous	0.3	0.5	2.0	0.6	1.4	0.6	0.3	0.5	-0.2
Mood swings	0.3	0.6	2.7	-0.7	-1.6	-0.3	0.5	0.0	-0.2
Qualifications: nursing, teaching	0.3	0.5	1.7	-1.3	-0.6	0.2	-0.8	0.2	0.0
Breast cancer (self-reported)	0.3	0.4	0.9	-0.0	-0.4	0.9	0.7	0.1	0.9
Asthma (self-reported)	0.3	0.7	1.7	-1.0	0.8	0.8	1.3	-0.4	0.1
Wears glasses or contact lenses	0.3	0.3	1.1	-0.2	0.3	0.6	0.5	-1.0	0.3
Leg fat percentage (left)	0.3	0.9	3.1	0.1	1.5	-0.1	0.6	-0.0	1.8
Irritability	0.3	0.5	1.8	-0.9	-0.3	0.4	-1.3	-0.4	-0.6
Supplements: Calcium	0.3	0.4	0.9	0.8	0.3	-0.0	0.3	-0.8	-0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	-0.7	-0.6	-0.7	-0.7	0.3	-0.1
Heart disease (siblings)	0.3	0.3	0.7	0.7	0.8	-0.3	-0.6	0.4	0.5
Depression (Nagel 2018)	0.2	0.3	0.9	-0.8	-0.2	-0.3	-0.2	0.9	0.2
Crohns Disease (2017)	0.2	0.5	1.1	0.5	-0.1	0.8	-0.7	-0.6	-1.0
Irritable Bowel Disease (IBD)	0.2	0.4	0.5	-0.7	-0.6	0.7	-0.6	-0.4	-0.7
Crohns Disease (2012)	0.2	0.3	1.0	0.0	0.0	0.0	0.0	-0.9	-1.0
Fasting Glucose	0.2	0.3	1.2	-1.1	-0.1	-0.6	0.2	0.1	0.3
HDL Cholesterol	0.2	0.4	1.0	0.4	0.7	0.4	0.3	1.0	-0.8
Lupus	0.2	0.3	1.1	-0.4	0.3	-1.1	0.5	0.4	-0.2
Schizophrenia (2014)	0.2	0.4	1.1	0.0	-0.5	0.3	-1.1	-0.1	-1.0
Systolic Blood Pressure	0.2	0.8	2.9	-1.7	-0.9	-0.6	0.4	-0.9	-0.2
Lung FVC	0.2	0.9	2.2	1.1	-0.8	-0.8	-1.0	1.5	-0.0
Number of treatments/medications taken	0.2	0.4	1.5	-1.2	-0.1	-0.9	-0.5	0.4	0.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-1.2	0.2	-0.4	-0.1	-0.1	0.2
Systolic blood pressure, automated reading	0.2	0.6	1.8	0.3	-0.1	-1.3	0.9	-0.2	0.8
Severe depression (siblings)	0.2	0.2	0.7	0.2	-0.5	-0.8	-0.2	0.2	0.5
Illnesses of siblings	0.2	0.3	1.2	-0.3	-1.1	-0.6	0.4	-0.2	-0.4
Impedance of arm (right)	0.2	0.9	4.5	-2.1	-0.5	0.2	0.2	-0.5	0.6
Happiness	0.2	0.3	1.6	-1.2	-0.1	0.2	0.3	-0.1	0.1
Loud music exposure frequency	0.2	0.2	0.4	-0.7	0.6	0.1	0.2	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.0	0.4	-0.6	0.6	-0.9	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.1	0.4	0.7	-0.3	-0.3	1.0
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	-0.2	0.8	-0.0	-0.5	-0.5	0.7
Leg fat percentage (right)	0.2	0.9	2.7	-0.3	1.3	0.2	0.9	-0.3	1.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.6	0.7	-0.5	-0.4	0.2	0.1
Had major operations	0.2	0.2	1.1	0.5	1.0	0.1	-0.0	-0.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.8	-0.5	-0.2	-0.5	0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.9	0.1	0.5	-0.7	0.9	0.2
Age started oral contraceptive pill	0.2	0.2	0.6	0.4	-0.8	0.1	0.6	0.4	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.1	-0.1	0.6	-0.0	-0.4	-0.4
Waist Hip Ratio (WHR)	0.1	0.6	2.0	1.0	0.4	0.3	0.6	-1.4	0.1
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.2	-0.7	0.2	-0.4	-0.2	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.4	-0.5	-0.0	-0.6	0.0	-0.6
Allergy	0.1	0.3	1.0	-0.3	-1.0	0.4	0.0	-0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.5	0.3	-0.7	0.4	-0.1	-0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.7	-0.5	-0.1	-0.1	-0.0	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.6	-0.5	-0.1	0.3	-0.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.5	0.2	-0.2	-0.5	0.6	0.2
Birth weight	0.1	0.1	0.2	0.4	-0.4	-0.0	-0.1	0.5	0.4
Pulse wave peak to peak time	0.1	0.1	0.3	-0.4	0.6	-0.0	-0.4	0.3	-0.0
Shortness of breath walking on level ground	0.1	0.1	0.6	-0.2	-0.4	-0.8	-0.1	0.2	0.1
Comparative height size at age 10	0.1	0.8	1.8	1.4	-0.6	-0.4	-0.8	-0.4	1.3
Medication: Paracetamol	0.1	0.2	0.4	-0.6	0.6	0.3	-0.1	0.2	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.5	0.0	0.6	0.3	0.3	-0.2	-0.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

CYBA

Models

Trait associations