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chr10:103,527,782-105,910,221

Best TWAS P=2.79e-19 · Best GWAS P=4.58e-17 conditioned to 0.17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	3.78	6.9	4.8e-12	-0.62	0.13	0.32	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARL3	0.03	0.03	lasso	6	0.03	1.8e-04	-5.76	7.2	8.5e-13	-0.92	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	TMEM180	0.24	0.16	enet	11	0.18	2.2e-14	-8.18	-7.2	8.0e-13	0.79	0.09	0.91	FALSE
4	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	-8.40	8.6	6.0e-18	-0.87	0.05	0.63	FALSE
5	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-8.20	-8.7	2.6e-18	0.82	0.06	0.92	FALSE
6	GTEx	Artery Aorta	TMEM180	0.25	0.23	enet	37	0.25	7.4e-14	-8.01	-5.8	7.5e-09	0.75	0.08	0.92	FALSE
7	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	-8.01	-7.8	9.1e-15	0.84	0.06	0.78	FALSE
8	GTEx	Artery Tibial	TMEM180	0.07	0.05	enet	14	0.03	3.8e-03	-8.20	-7.2	7.0e-13	0.85	0.06	0.93	FALSE
9	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	-8.18	-8.1	6.8e-16	0.93	0.03	0.96	FALSE
10	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	-8.35	-8.5	1.3e-17	0.90	0.04	0.96	FALSE
11	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	3.47	5.9	4.1e-09	-0.44	0.23	0.31	FALSE
12	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	-8.23	-8.2	2.7e-16	0.92	0.04	0.87	FALSE
13	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	6.41	6.7	1.7e-11	-0.33	0.14	0.06	FALSE
14	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	-8.23	-8.5	2.3e-17	0.94	0.04	0.96	FALSE
15	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	6.43	6.6	5.4e-11	-0.41	0.14	0.23	FALSE
16	GTEx	Breast Mammary Tissue (Male)	TMEM180	0.26	0.15	lasso	17	0.17	1.0e-04	-8.35	-7.0	2.4e-12	0.89	0.04	0.89	FALSE
17	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-6.66	7.2	5.0e-13	-0.56	0.03	0.25	FALSE
18	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-8.39	-9.0	2.8e-19	0.79	0.04	0.86	TRUE
19	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	3.20	5.4	5.9e-08	-0.14	0.08	0.08	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-7.55	7.1	1.7e-12	-0.60	0.14	0.76	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-8.02	7.9	3.0e-15	-0.75	0.10	0.58	FALSE
22	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-8.09	8.1	5.7e-16	-0.77	0.12	0.64	FALSE
23	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	-8.35	-8.4	3.4e-17	0.89	0.04	0.96	FALSE
24	GTEx	Colon Transverse	TMEM180	0.16	0.15	enet	11	0.13	1.2e-06	-8.20	-7.9	2.3e-15	0.88	0.06	0.94	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	TMEM180	0.22	0.23	enet	11	0.27	3.0e-10	-8.23	-7.7	1.7e-14	0.86	0.06	0.94	FALSE
26	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-4.96	-6.6	4.8e-11	0.70	0.07	0.91	FALSE
27	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-8.23	-8.1	3.9e-16	0.78	0.06	0.91	FALSE
28	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	-8.23	-7.9	2.2e-15	0.93	0.05	0.95	FALSE
29	GTEx	Heart Atrial Appendage	TMEM180	0.42	0.21	enet	35	0.27	2.1e-12	-8.35	-5.4	7.2e-08	0.67	0.05	0.95	FALSE
30	GTEx	Heart Left Ventricle	TMEM180	0.19	0.17	enet	14	0.17	3.7e-09	-8.35	-7.3	3.3e-13	0.90	0.04	0.96	FALSE
31	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-8.02	-7.6	3.8e-14	0.66	0.12	0.86	FALSE
32	GTEx	Liver	CALHM2	0.20	0.01	enet	34	0.08	2.9e-03	3.56	-5.4	7.1e-08	0.08	0.04	0.42	TRUE
33	GTEx	Lung	TMEM180	0.12	0.11	lasso	4	0.13	5.1e-10	-8.01	-6.8	7.2e-12	0.88	0.04	0.96	FALSE
34	GTEx	Nerve Tibial	TMEM180	0.32	0.30	enet	16	0.32	2.0e-23	-8.20	-7.9	2.7e-15	0.89	0.06	0.94	FALSE
35	GTEx	Nerve Tibial	RP11-18I14.10	0.05	0.01	enet	8	0.02	1.4e-02	4.33	-5.3	1.0e-07	0.68	0.04	0.76	FALSE
36	GTEx	Ovary	TMEM180	0.41	0.24	enet	18	0.23	2.4e-06	-8.18	-6.7	2.9e-11	0.74	0.06	0.91	FALSE
37	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	-8.39	-6.9	4.3e-12	0.82	0.02	0.68	FALSE
38	GTEx	Pituitary	TMEM180	0.36	0.23	enet	12	0.20	1.1e-05	-8.35	-7.2	5.4e-13	0.84	0.05	0.92	FALSE
39	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-8.02	8.1	4.1e-16	-0.77	0.15	0.84	FALSE
40	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-8.10	6.8	1.5e-11	-0.66	0.14	0.85	FALSE
41	GTEx	Spleen	TMEM180	0.16	0.21	lasso	3	0.05	2.6e-02	-8.23	-7.7	1.7e-14	0.90	0.04	0.82	FALSE
42	GTEx	Stomach	TMEM180	0.33	0.22	lasso	8	0.21	2.2e-10	-8.35	-7.7	9.6e-15	0.85	0.04	0.96	FALSE
43	GTEx	Stomach	CNNM2	0.11	0.02	enet	26	0.07	3.6e-04	-8.18	5.8	6.4e-09	-0.60	0.04	0.75	FALSE
44	GTEx	Testis	TMEM180	0.19	0.05	enet	24	0.12	7.9e-06	-8.20	-8.0	1.9e-15	0.72	0.05	0.94	FALSE
45	GTEx	Thyroid	TMEM180	0.31	0.38	enet	20	0.42	8.1e-35	-8.35	-6.8	1.2e-11	0.87	0.06	0.94	FALSE
46	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	-8.01	-6.5	5.7e-11	0.64	0.04	0.46	FALSE
47	METSIM	Adipose	ARL3	0.04	0.00	bslmm	364	0.01	1.4e-02	0.79	5.5	4.4e-08	-0.65	0.04	0.72	FALSE
48	METSIM	Adipose	TMEM180	0.28	0.25	enet	33	0.26	2.5e-39	-8.23	-7.5	4.5e-14	0.86	0.07	0.93	FALSE
49	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-8.23	8.6	5.5e-18	-0.84	0.07	0.93	FALSE
50	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	-8.23	6.9	5.7e-12	-0.80	0.04	0.95	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	TRIM8	0.09	0.03	enet	25	0.06	3.7e-08	4.53	6.1	1.0e-09	-0.75	0.24	0.76	FALSE
52	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-8.39	8.0	1.7e-15	-0.91	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-6.68	-6.7	1.6e-11	0.62	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	1.64	6.7	1.6e-11	-0.70	0.02	0.74	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	-8.15	8.3	1.3e-16	-0.89	0.02	0.79	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	-8.14	7.7	1.9e-14	-0.80	0.03	0.96	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACTR1A	0.04	0.01	blup	51	0.02	7.1e-04	-8.23	-5.3	9.5e-08	0.74	0.01	0.69	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	-8.21	-8.2	2.3e-16	0.92	0.06	0.93	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-8.02	5.3	1.1e-07	-0.38	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-8.09	-8.9	6.4e-19	0.91	0.04	0.68	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	-8.01	-8.1	6.8e-16	0.87	0.01	0.92	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-8.22	-8.3	7.6e-17	0.74	0.02	0.98	FALSE