[Hub]/) : Traits : Comparative height size at age 10 :

chr2:231,564,626-234,434,621

Best TWAS P=1.25e-29 · Best GWAS P=7.92e-29 conditioned to 4.85e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C2orf82 0.14 0.22 lasso 6 0.23 3.8e-27 -5.7 5.7 9.3e-09 0.03 1.00 0.00 FALSE
2 GTEx Artery Aorta B3GNT7 0.30 0.20 lasso 6 0.16 3.2e-09 -4.9 5.1 2.8e-07 0.01 1.00 0.00 TRUE
3 GTEx Artery Coronary RP11-690I21.1 0.24 -0.01 lasso 8 -0.01 6.8e-01 -8.3 9.1 7.0e-20 -0.57 0.07 0.15 TRUE
4 GTEx Artery Tibial EIF4E2 0.09 0.06 lasso 1 0.05 1.7e-04 6.7 -6.7 2.0e-11 0.03 0.79 0.01 FALSE
5 GTEx Brain Caudate basal ganglia C2orf82 0.27 0.26 lasso 1 0.24 1.2e-07 -5.7 5.7 1.6e-08 0.02 0.71 0.02 FALSE
6 GTEx Brain Cerebellar Hemisphere PTMA 0.28 0.12 enet 19 0.06 1.5e-02 -7.7 8.6 1.1e-17 -0.51 0.04 0.59 FALSE
7 GTEx Brain Cerebellum C2orf82 0.15 0.18 lasso 2 0.13 1.1e-04 -5.7 5.6 2.7e-08 0.02 0.35 0.04 FALSE
8 GTEx Brain Cortex C2orf82 0.17 0.18 lasso 1 0.08 2.8e-03 -5.7 5.7 1.6e-08 0.02 0.32 0.04 FALSE
9 GTEx Brain Frontal Cortex BA9 C2orf82 0.24 0.16 lasso 10 0.12 3.9e-04 -5.7 6.0 1.6e-09 0.02 0.56 0.02 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia C2orf82 0.19 0.18 lasso 5 0.14 1.1e-04 -5.7 5.2 2.3e-07 0.01 0.41 0.03 FALSE
11 GTEx Brain Putamen basal ganglia C2orf82 0.28 0.22 lasso 3 0.18 5.3e-05 -5.7 6.3 2.8e-10 0.01 0.18 0.07 FALSE
12 GTEx Cells Transformed fibroblasts RP11-690I21.1 0.14 0.10 lasso 3 0.10 5.4e-08 -6.4 7.0 2.1e-12 -0.04 0.99 0.00 TRUE
13 GTEx Esophagus Mucosa RP11-690I21.1 0.11 0.03 lasso 6 0.00 1.9e-01 -6.5 6.5 6.2e-11 -0.04 0.24 0.06 FALSE
14 GTEx Heart Atrial Appendage COPS7B 0.22 0.01 lasso 6 0.01 1.3e-01 -7.7 -8.6 6.8e-18 0.76 0.04 0.42 FALSE
15 GTEx Liver PDE6D 0.21 0.10 lasso 4 0.09 1.8e-03 -10.6 -11.3 1.2e-29 0.82 0.02 0.89 TRUE
16 GTEx Prostate PTMA 0.62 0.08 lasso 12 0.14 3.0e-04 -6.8 -7.6 3.0e-14 0.52 0.02 0.62 FALSE
17 GTEx Prostate RP11-690I21.1 0.26 0.05 enet 36 0.04 2.9e-02 -6.5 5.4 8.0e-08 -0.11 0.08 0.11 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic C2orf82 0.19 0.19 lasso 5 0.20 5.5e-11 -5.7 5.4 6.5e-08 0.03 1.00 0.00 FALSE
19 GTEx Skin Sun Exposed Lower leg C2orf82 0.16 0.14 lasso 4 0.15 1.3e-12 -5.7 5.4 6.2e-08 0.02 1.00 0.00 FALSE
20 GTEx Skin Sun Exposed Lower leg RP11-690I21.1 0.08 0.05 lasso 3 0.02 3.8e-03 -6.4 6.8 1.4e-11 -0.03 0.42 0.02 FALSE
21 GTEx Spleen RP11-690I21.1 0.20 0.11 enet 10 0.14 1.8e-04 -4.7 5.7 1.4e-08 -0.02 0.23 0.05 FALSE
22 GTEx Testis DIS3L2 0.22 0.00 enet 16 0.00 2.1e-01 -2.9 6.0 2.4e-09 -0.07 0.06 0.05 FALSE
23 ROSMAP Brain Pre-frontal Cortex DIS3L2 0.04 0.00 enet 17 0.01 6.7e-03 -10.8 6.8 8.6e-12 -0.21 0.30 0.21 TRUE
24 ROSMAP Brain Pre-frontal Cortex C2orf82 0.31 0.50 enet 24 0.50 1.3e-73 -5.7 5.9 4.4e-09 0.03 1.00 0.00 FALSE
25 YFS Blood EIF4E2 0.06 0.04 enet 27 0.04 2.8e-13 6.9 7.2 8.0e-13 -0.02 1.00 0.00 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma DIS3L2 0.05 0.02 enet 10 0.02 3.8e-05 -5.0 -10.5 6.9e-26 0.15 0.10 0.02 TRUE
27 The Cancer Genome Atlas Breast Invasive Carcinoma EIF4E2 0.03 0.03 enet 8 0.04 4.4e-08 6.7 -6.5 5.6e-11 0.03 0.02 0.98 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma TIGD1 0.05 0.04 lasso 3 0.04 8.1e-09 6.6 -6.2 5.5e-10 0.17 0.35 0.65 FALSE
29 The Cancer Genome Atlas Glioblastoma Multiforme C2orf82 0.20 0.24 lasso 8 0.20 9.1e-07 -5.7 5.8 5.9e-09 0.03 0.04 0.96 FALSE
30 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EFHD1 0.11 0.01 blup 70 0.03 1.0e-02 3.7 6.9 6.5e-12 -0.01 0.05 0.10 FALSE
31 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma KCNJ13 0.07 0.06 enet 13 0.05 4.7e-04 -6.2 5.6 2.0e-08 0.01 0.03 0.86 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma C2orf82 0.14 0.20 enet 6 0.19 3.1e-21 -5.7 5.8 8.3e-09 0.02 0.12 0.88 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma EIF4E2 0.03 0.01 blup 60 0.02 2.7e-03 6.6 -6.7 2.3e-11 0.09 0.01 0.89 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma GIGYF2 0.02 0.01 lasso 3 0.01 5.3e-02 -6.2 -6.3 2.5e-10 -0.02 0.04 0.82 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma NGEF 0.03 0.01 blup 130 0.01 2.0e-02 -6.2 5.2 1.7e-07 0.01 0.02 0.90 FALSE
36 The Cancer Genome Atlas Lung Adenocarcinoma CHRNG 0.04 0.00 blup 58 0.00 1.3e-01 4.3 -8.3 1.1e-16 0.13 0.01 0.48 TRUE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DIS3L2 0.06 0.02 blup 173 0.02 7.5e-04 2.3 5.8 8.5e-09 -0.35 0.37 0.06 TRUE
38 The Cancer Genome Atlas Pancreatic Adenocarcinoma KCNJ13 0.07 0.07 blup 36 0.06 2.4e-03 -6.2 6.8 1.4e-11 0.01 0.01 0.87 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma GIGYF2 0.04 0.00 blup 103 0.02 2.1e-03 -5.7 -6.8 1.1e-11 0.01 0.06 0.72 TRUE
40 The Cancer Genome Atlas Stomach Adenocarcinoma KCNJ13 0.09 0.06 blup 36 0.08 3.8e-06 -6.2 6.4 1.3e-10 0.01 0.01 0.98 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma EIF4E2 0.03 0.01 blup 63 0.02 4.7e-03 6.7 -6.9 6.6e-12 0.09 0.02 0.80 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma KCNJ13 0.03 0.00 blup 35 0.01 4.3e-02 3.7 -6.4 1.3e-10 -0.01 0.01 0.59 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma NGEF 0.04 0.03 enet 7 0.03 5.6e-04 3.7 -5.2 1.7e-07 0.00 0.04 0.92 FALSE