Best TWAS P=1.25e-29 · Best GWAS P=7.92e-29 conditioned to 4.85e-12
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C2orf82 | 0.14 | 0.22 | lasso | 6 | 0.23 | 3.8e-27 | -5.7 | 5.7 | 9.3e-09 | 0.03 | 1.00 | 0.00 | FALSE |
2 | GTEx | Artery Aorta | B3GNT7 | 0.30 | 0.20 | lasso | 6 | 0.16 | 3.2e-09 | -4.9 | 5.1 | 2.8e-07 | 0.01 | 1.00 | 0.00 | TRUE |
3 | GTEx | Artery Coronary | RP11-690I21.1 | 0.24 | -0.01 | lasso | 8 | -0.01 | 6.8e-01 | -8.3 | 9.1 | 7.0e-20 | -0.57 | 0.07 | 0.15 | TRUE |
4 | GTEx | Artery Tibial | EIF4E2 | 0.09 | 0.06 | lasso | 1 | 0.05 | 1.7e-04 | 6.7 | -6.7 | 2.0e-11 | 0.03 | 0.79 | 0.01 | FALSE |
5 | GTEx | Brain Caudate basal ganglia | C2orf82 | 0.27 | 0.26 | lasso | 1 | 0.24 | 1.2e-07 | -5.7 | 5.7 | 1.6e-08 | 0.02 | 0.71 | 0.02 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | PTMA | 0.28 | 0.12 | enet | 19 | 0.06 | 1.5e-02 | -7.7 | 8.6 | 1.1e-17 | -0.51 | 0.04 | 0.59 | FALSE |
7 | GTEx | Brain Cerebellum | C2orf82 | 0.15 | 0.18 | lasso | 2 | 0.13 | 1.1e-04 | -5.7 | 5.6 | 2.7e-08 | 0.02 | 0.35 | 0.04 | FALSE |
8 | GTEx | Brain Cortex | C2orf82 | 0.17 | 0.18 | lasso | 1 | 0.08 | 2.8e-03 | -5.7 | 5.7 | 1.6e-08 | 0.02 | 0.32 | 0.04 | FALSE |
9 | GTEx | Brain Frontal Cortex BA9 | C2orf82 | 0.24 | 0.16 | lasso | 10 | 0.12 | 3.9e-04 | -5.7 | 6.0 | 1.6e-09 | 0.02 | 0.56 | 0.02 | FALSE |
10 | GTEx | Brain Nucleus accumbens basal ganglia | C2orf82 | 0.19 | 0.18 | lasso | 5 | 0.14 | 1.1e-04 | -5.7 | 5.2 | 2.3e-07 | 0.01 | 0.41 | 0.03 | FALSE |
11 | GTEx | Brain Putamen basal ganglia | C2orf82 | 0.28 | 0.22 | lasso | 3 | 0.18 | 5.3e-05 | -5.7 | 6.3 | 2.8e-10 | 0.01 | 0.18 | 0.07 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | RP11-690I21.1 | 0.14 | 0.10 | lasso | 3 | 0.10 | 5.4e-08 | -6.4 | 7.0 | 2.1e-12 | -0.04 | 0.99 | 0.00 | TRUE |
13 | GTEx | Esophagus Mucosa | RP11-690I21.1 | 0.11 | 0.03 | lasso | 6 | 0.00 | 1.9e-01 | -6.5 | 6.5 | 6.2e-11 | -0.04 | 0.24 | 0.06 | FALSE |
14 | GTEx | Heart Atrial Appendage | COPS7B | 0.22 | 0.01 | lasso | 6 | 0.01 | 1.3e-01 | -7.7 | -8.6 | 6.8e-18 | 0.76 | 0.04 | 0.42 | FALSE |
15 | GTEx | Liver | PDE6D | 0.21 | 0.10 | lasso | 4 | 0.09 | 1.8e-03 | -10.6 | -11.3 | 1.2e-29 | 0.82 | 0.02 | 0.89 | TRUE |
16 | GTEx | Prostate | PTMA | 0.62 | 0.08 | lasso | 12 | 0.14 | 3.0e-04 | -6.8 | -7.6 | 3.0e-14 | 0.52 | 0.02 | 0.62 | FALSE |
17 | GTEx | Prostate | RP11-690I21.1 | 0.26 | 0.05 | enet | 36 | 0.04 | 2.9e-02 | -6.5 | 5.4 | 8.0e-08 | -0.11 | 0.08 | 0.11 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | C2orf82 | 0.19 | 0.19 | lasso | 5 | 0.20 | 5.5e-11 | -5.7 | 5.4 | 6.5e-08 | 0.03 | 1.00 | 0.00 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | C2orf82 | 0.16 | 0.14 | lasso | 4 | 0.15 | 1.3e-12 | -5.7 | 5.4 | 6.2e-08 | 0.02 | 1.00 | 0.00 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | RP11-690I21.1 | 0.08 | 0.05 | lasso | 3 | 0.02 | 3.8e-03 | -6.4 | 6.8 | 1.4e-11 | -0.03 | 0.42 | 0.02 | FALSE |
21 | GTEx | Spleen | RP11-690I21.1 | 0.20 | 0.11 | enet | 10 | 0.14 | 1.8e-04 | -4.7 | 5.7 | 1.4e-08 | -0.02 | 0.23 | 0.05 | FALSE |
22 | GTEx | Testis | DIS3L2 | 0.22 | 0.00 | enet | 16 | 0.00 | 2.1e-01 | -2.9 | 6.0 | 2.4e-09 | -0.07 | 0.06 | 0.05 | FALSE |
23 | ROSMAP | Brain Pre-frontal Cortex | DIS3L2 | 0.04 | 0.00 | enet | 17 | 0.01 | 6.7e-03 | -10.8 | 6.8 | 8.6e-12 | -0.21 | 0.30 | 0.21 | TRUE |
24 | ROSMAP | Brain Pre-frontal Cortex | C2orf82 | 0.31 | 0.50 | enet | 24 | 0.50 | 1.3e-73 | -5.7 | 5.9 | 4.4e-09 | 0.03 | 1.00 | 0.00 | FALSE |
25 | YFS | Blood | EIF4E2 | 0.06 | 0.04 | enet | 27 | 0.04 | 2.8e-13 | 6.9 | 7.2 | 8.0e-13 | -0.02 | 1.00 | 0.00 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DIS3L2 | 0.05 | 0.02 | enet | 10 | 0.02 | 3.8e-05 | -5.0 | -10.5 | 6.9e-26 | 0.15 | 0.10 | 0.02 | TRUE |
27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EIF4E2 | 0.03 | 0.03 | enet | 8 | 0.04 | 4.4e-08 | 6.7 | -6.5 | 5.6e-11 | 0.03 | 0.02 | 0.98 | FALSE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TIGD1 | 0.05 | 0.04 | lasso | 3 | 0.04 | 8.1e-09 | 6.6 | -6.2 | 5.5e-10 | 0.17 | 0.35 | 0.65 | FALSE |
29 | The Cancer Genome Atlas | Glioblastoma Multiforme | C2orf82 | 0.20 | 0.24 | lasso | 8 | 0.20 | 9.1e-07 | -5.7 | 5.8 | 5.9e-09 | 0.03 | 0.04 | 0.96 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFHD1 | 0.11 | 0.01 | blup | 70 | 0.03 | 1.0e-02 | 3.7 | 6.9 | 6.5e-12 | -0.01 | 0.05 | 0.10 | FALSE |
31 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KCNJ13 | 0.07 | 0.06 | enet | 13 | 0.05 | 4.7e-04 | -6.2 | 5.6 | 2.0e-08 | 0.01 | 0.03 | 0.86 | FALSE |
32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf82 | 0.14 | 0.20 | enet | 6 | 0.19 | 3.1e-21 | -5.7 | 5.8 | 8.3e-09 | 0.02 | 0.12 | 0.88 | FALSE |
33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EIF4E2 | 0.03 | 0.01 | blup | 60 | 0.02 | 2.7e-03 | 6.6 | -6.7 | 2.3e-11 | 0.09 | 0.01 | 0.89 | FALSE |
34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIGYF2 | 0.02 | 0.01 | lasso | 3 | 0.01 | 5.3e-02 | -6.2 | -6.3 | 2.5e-10 | -0.02 | 0.04 | 0.82 | FALSE |
35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NGEF | 0.03 | 0.01 | blup | 130 | 0.01 | 2.0e-02 | -6.2 | 5.2 | 1.7e-07 | 0.01 | 0.02 | 0.90 | FALSE |
36 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNG | 0.04 | 0.00 | blup | 58 | 0.00 | 1.3e-01 | 4.3 | -8.3 | 1.1e-16 | 0.13 | 0.01 | 0.48 | TRUE |
37 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DIS3L2 | 0.06 | 0.02 | blup | 173 | 0.02 | 7.5e-04 | 2.3 | 5.8 | 8.5e-09 | -0.35 | 0.37 | 0.06 | TRUE |
38 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KCNJ13 | 0.07 | 0.07 | blup | 36 | 0.06 | 2.4e-03 | -6.2 | 6.8 | 1.4e-11 | 0.01 | 0.01 | 0.87 | FALSE |
39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GIGYF2 | 0.04 | 0.00 | blup | 103 | 0.02 | 2.1e-03 | -5.7 | -6.8 | 1.1e-11 | 0.01 | 0.06 | 0.72 | TRUE |
40 | The Cancer Genome Atlas | Stomach Adenocarcinoma | KCNJ13 | 0.09 | 0.06 | blup | 36 | 0.08 | 3.8e-06 | -6.2 | 6.4 | 1.3e-10 | 0.01 | 0.01 | 0.98 | FALSE |
41 | The Cancer Genome Atlas | Thyroid Carcinoma | EIF4E2 | 0.03 | 0.01 | blup | 63 | 0.02 | 4.7e-03 | 6.7 | -6.9 | 6.6e-12 | 0.09 | 0.02 | 0.80 | FALSE |
42 | The Cancer Genome Atlas | Thyroid Carcinoma | KCNJ13 | 0.03 | 0.00 | blup | 35 | 0.01 | 4.3e-02 | 3.7 | -6.4 | 1.3e-10 | -0.01 | 0.01 | 0.59 | FALSE |
43 | The Cancer Genome Atlas | Thyroid Carcinoma | NGEF | 0.04 | 0.03 | enet | 7 | 0.03 | 5.6e-04 | 3.7 | -5.2 | 1.7e-07 | 0.00 | 0.04 | 0.92 | FALSE |