TWAS hub - PTMA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.279	0.095	1.5e-03	0.125	NA	0.056	NA	0.017	0.00043	NA	0.015	NA	0.1200
2	GTEx	Prostate	0.623	0.109	8.3e-05	0.082	NA	0.053	NA	0.135	0.00420	NA	0.019	NA	0.0003

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	13.6	261.5	309.8	17.6	-14.6
Comparative height size at age 10	11.9	65.6	73.4	8.6	-7.6
Standing height	10.1	99.9	118.8	10.9	-9.0
Forced expiratory volume in 1-second (FEV1), predicted	8.0	16.6	22.3	4.7	-3.3
Trunk predicted mass	5.5	31.2	41.3	6.4	-4.6
Hair/balding pattern: Pattern 2	5.4	6.9	13.4	0.6	-3.7
Trunk fat-free mass	5.4	30.8	41.1	6.4	-4.5
Arm predicted mass (right)	4.2	21.3	30.1	5.5	-3.5
Bipolar Disorder or Schizophrenia	3.9	9.4	11.2	3.4	-2.8
Schizophrenia (2018)	3.9	8.1	9.7	3.1	-2.5
Arm fat-free mass (right)	3.9	19.9	28.1	5.3	-3.4
Whole body water mass	3.9	22.0	30.1	5.5	-3.7
Financial situation satisfaction	3.9	4.8	7.9	-1.3	2.8
Tense / ‘highly strung’	3.8	6.3	6.6	2.5	-2.6
Family relationship satisfaction	3.8	4.7	7.3	-1.4	2.7
Whole body fat-free mass	3.8	21.7	30.5	5.5	-3.6
Medication: Co-codamol	3.7	4.3	6.3	-1.5	2.5
Arm fat-free mass (left)	3.7	18.6	26.5	5.1	-3.3
Hearing aid user	3.6	4.1	5.2	2.3	-1.7
Pain type(s) experienced in last month: Hip pain	3.5	4.4	4.7	2.2	-2.0
Arm predicted mass (left)	3.4	17.4	24.5	5.0	-3.2
Birth weight of first child	3.3	6.0	8.2	2.9	-1.9
Basal metabolic rate	3.3	18.1	26.2	5.1	-3.1
Pain experienced in last month	3.2	5.4	5.6	-2.3	2.4
Waist Hip Ratio (WHR)	3.1	13.8	18.0	3.1	-4.2
Sitting height	3.0	21.3	31.5	5.6	-3.4
Ever used hormone-replacement therapy (HRT)	2.9	3.7	6.1	-1.1	2.5
Chronic bronchitis/emphysema (mother)	2.8	3.2	4.6	2.1	1.3
Deep venous thrombosis (DVT) (self-reported)	2.8	3.5	7.0	-0.2	2.6
Leg pain on walking	2.6	3.2	6.3	2.5	-0.4
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	4.1	-1.5	-2.0
Fractured/broken bones in last 5 years	2.6	3.4	6.5	-0.6	2.5
Blood clot in the leg (DVT)	2.4	3.1	6.2	-0.3	2.5
Chronic bronchitis/emphysema (father)	2.3	2.7	3.5	-1.4	1.9
Osteoporosis (self-reported)	2.3	2.9	3.8	1.9	-1.4
Wears glasses or contact lenses	2.3	2.7	5.3	-2.3	0.2
Worry (Nagel 2018)	2.2	4.6	6.9	2.6	-1.5
Major Depression (MDD)	2.2	2.6	2.7	1.6	-1.6
Multivitamins +/- minerals	2.2	2.9	4.0	-1.3	-2.0
Severe depression (siblings)	2.1	2.4	4.6	2.1	-0.3
Leg fat-free mass (left)	2.0	10.5	16.3	4.0	-2.1
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.4	2.1	-0.4
Forced vital capacity (FVC), Best measure	2.0	7.5	10.8	3.3	-2.0
Osteoarthritis (self-reported)	2.0	2.6	4.3	1.0	-2.1
Medication: Gliclazide	2.0	2.2	3.3	-1.8	1.1
Supplements: Fish oil (including cod liver oil)	2.0	2.6	3.2	1.8	-1.4
Body Mass Index (BMI) (2010)	1.9	2.6	3.8	-1.2	2.0
Leg predicted mass (left)	1.9	10.2	16.1	4.0	-2.1
Nervous feelings	1.9	3.6	5.6	1.2	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	7.8	2.8	-2.1
Hair/balding pattern: Pattern 4	1.9	4.6	8.5	-0.9	2.9
Comparative body size at age 10	1.9	5.2	8.0	-1.6	2.8
Emphysema/chronic bronchitis	1.9	2.1	2.6	1.6	-1.3
Qualifications: nursing, teaching	1.9	2.9	3.3	1.6	-1.8
Depressed Affect (Nagel 2018)	1.8	3.7	6.5	-1.0	2.5
Heel T-Score	1.8	14.5	24.0	-4.9	2.2
Supplements: Glucosamine	1.8	2.4	4.6	0.4	-2.1
Worry too long after embarrassment	1.8	3.0	4.5	-2.1	1.2
Leg fat-free mass (right)	1.8	9.8	15.4	3.9	-2.0
Leg predicted mass (right)	1.8	9.7	14.7	3.8	-2.1
Townsend deprivation index at recruitment	1.7	2.3	4.0	0.9	-2.0
Average weekly fortified wine intake	1.7	2.0	2.8	-1.7	1.1
Forced vital capacity (FVC)	1.7	6.4	8.4	2.9	-2.1
Illnesses of siblings	1.7	2.3	3.4	1.8	-1.1
Weight	1.6	7.7	13.7	3.7	-1.3
High blood pressure (siblings)	1.6	2.2	2.5	-1.6	1.4
Health satisfaction	1.6	2.0	4.0	-0.0	2.0
Mean time to correctly identify matches	1.6	3.1	4.3	2.1	-1.4
Chest pain or discomfort	1.6	2.3	2.9	1.7	-1.3
BMI	1.5	8.9	13.2	-2.1	3.6
Frequency of depressed mood in last 2 weeks	1.5	2.2	4.0	2.0	0.5
Forced expiratory volume in 1-second (FEV1)	1.5	4.9	5.6	2.4	-2.0
Alcohol intake frequency.	1.5	3.5	5.6	2.4	-1.2
Smoking status: Previous	1.5	2.2	3.7	-1.9	0.8
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	3.6	1.9	-0.3
Fed-up feelings	1.4	2.6	4.0	-1.0	2.0
Age when periods started (menarche)	1.4	3.4	6.0	-2.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.2	2.0	0.5
Hair/balding pattern: Pattern 3	1.4	2.1	2.1	-1.5	1.4
Medication: Amlodipine	1.4	2.0	2.1	-1.4	1.5
Number of full sisters	1.4	1.7	2.6	1.6	-0.9
Mineral and other dietary supplements	1.4	1.9	2.2	-1.3	1.5
Medication: Lisinopril	1.4	1.8	2.2	-1.5	1.2
Schizophrenia (2014)	1.3	3.0	4.1	2.0	-1.4
Blood Eosinophil Count	1.3	9.9	16.0	4.0	-1.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.8	-0.5	1.7
High blood pressure (mother)	1.3	1.8	2.1	-1.4	1.3
Breastfed as a baby	1.3	1.6	3.2	0.2	-1.8
Heart disease (mother)	1.3	1.6	2.1	-1.4	1.1
Supplements: Calcium	1.3	1.4	1.6	-1.1	-1.3
Reaction Time	1.2	2.3	3.2	1.8	-1.2
Neck or shoulder pain in last month	1.2	1.7	2.0	1.2	-1.4
Miserableness	1.2	2.1	3.8	-0.7	1.9
Age started oral contraceptive pill	1.2	1.5	1.9	-1.4	1.1
Hearing difficulty/problems: Yes	1.1	1.8	3.5	1.9	-0.2
Body mass index (BMI)	1.1	4.8	8.1	-1.2	2.9
Medication: Ramipril	1.1	1.4	2.5	1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.5	-0.1	1.6
Bipolar Disorder (2018)	1.0	1.6	1.6	1.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.7	1.6	0.2
Past tobacco smoking	1.0	1.8	3.0	1.7	-0.8
Lung cancer (father)	1.0	1.2	1.3	-1.1	1.0
Shortness of breath walking on level ground	1.0	1.2	2.4	0.2	1.5
Migraine (self-reported)	1.0	1.2	1.8	-1.3	0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	0.6	-1.4
Ever taken oral contraceptive pill	1.0	1.1	2.2	-1.5	-0.3
Ever smoked	1.0	1.8	2.0	-1.4	1.2
Breast Cancer	0.9	2.1	2.7	-1.6	1.2
HbA1C	0.9	1.0	1.2	-0.9	1.1
Blood White Count	0.9	6.6	8.7	3.0	-2.1
Medication for hormone replacement therapy	0.9	1.0	2.0	1.4	-0.0
Hand grip strength (right)	0.9	2.5	2.7	1.6	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.0	-0.2	-2.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.4	0.9	1.2
Arm fat percentage (right)	0.9	3.4	4.9	-1.4	2.2
Alcohol intake versus 10 years previously	0.9	1.3	2.4	0.5	-1.6
Illnesses of mother	0.9	1.1	1.4	0.9	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	1.3	1.1	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.1	-0.3	1.4
Headache pain in last month	0.9	1.6	2.5	1.6	-0.8
Gout (self-reported)	0.9	1.3	2.4	-0.3	1.6
Pulse rate, automated reading	0.9	3.0	4.6	1.2	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.5	0.8	-1.2
Arm fat percentage (left)	0.9	3.7	5.2	-1.5	2.3
Friendships satisfaction	0.9	1.1	1.7	-1.3	0.7
Alzheimer’s Disease (including proxy)	0.8	1.2	2.1	-0.5	1.5
Coronary Artery Disease (CAD)	0.8	0.9	0.9	1.0	-1.0
Fasting Glucose	0.8	0.9	1.1	-0.9	-1.1
Rheumatoid Arthritis	0.8	1.1	2.0	0.3	-1.4
Lung FVC	0.8	4.1	4.5	-1.9	2.1
Impedance of leg (right)	0.8	3.7	5.9	1.2	-2.4
Qualifications: CSEs or equivalent	0.8	1.0	1.2	-1.1	0.9
Serious illness, injury or assault to yourself	0.8	0.9	1.0	0.9	1.0
Number of incorrect matches in round	0.8	1.3	2.4	0.3	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.6	-1.0	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.4	0.4	1.6
Number of children fathered	0.8	0.9	1.7	-0.4	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.0	0.1	-1.4
Had major operations	0.8	0.9	1.4	-0.7	1.2
Medication: Aspirin	0.8	1.1	2.0	-0.4	-1.4
Knee pain experienced in last month	0.8	1.2	2.0	1.4	-0.7
Illnesses of siblings: Diabetes	0.8	1.0	2.0	-0.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.3	-0.7	1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	1.1	1.0	-0.9
Number of operations (self-reported)	0.8	1.3	1.6	-1.3	0.9
Myopia	0.8	1.2	1.5	1.2	-1.0
Neuroticism (2016)	0.7	1.0	1.1	1.0	-1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.0	0.7	1.0
Smoking Status	0.7	1.6	2.7	-1.6	0.8
Relative age of first facial hair	0.7	1.5	1.8	1.3	-1.1
Medication: Metformin	0.7	1.0	1.2	-1.1	-0.9
Impedance of leg (left)	0.7	3.4	6.0	0.9	-2.5
Pain all over the body in last month	0.7	0.7	1.4	1.2	0.4
Medication: Simvastatin	0.7	1.1	2.1	-1.4	0.3
Worrier / anxious feelings	0.7	1.3	1.8	1.3	-0.9
Pulse rate	0.7	1.2	2.5	-1.6	0.1
Mouth/teeth dental problems: Dentures	0.7	1.1	1.4	1.2	0.9
Medication: Allopurinol	0.7	0.9	1.7	-0.3	1.3
Commuting to job workplace: Walk	0.7	0.7	0.8	-0.8	0.9
Medication: Bendroflumethiazide	0.7	1.1	1.8	0.5	1.4
Unable to work because of sickness or disability	0.7	0.9	1.7	1.3	-0.2
Depression (Nagel 2018)	0.6	0.9	1.4	0.7	1.2
HDL Cholesterol	0.6	0.9	1.7	1.3	-0.4
Blood Red Count	0.6	6.1	6.6	2.4	-2.6
Hand grip strength (left)	0.6	1.5	2.4	1.5	-0.8
Relative age voice broke	0.6	1.0	1.2	0.8	1.1
Birth weight	0.6	1.2	2.1	1.4	-0.6
Exposure to tobacco smoke outside home	0.6	0.9	1.1	1.1	-0.8
Eye problems/disorders: None of the above	0.6	0.7	1.1	-0.6	1.0
Mood swings	0.6	1.1	1.4	-0.9	1.2
Diabetes diagnosed by doctor	0.6	0.9	1.6	-1.2	-0.6
Average weekly champagne plus white wine intake	0.6	0.8	1.1	-0.8	1.0
Guilty feelings	0.6	0.9	1.3	-1.1	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.4	-1.1
Commuting to job workplace: Public transport	0.6	0.7	1.4	0.0	1.2
Alcohol drinker status: Never	0.6	0.7	1.4	1.2	-0.1
Heart disease (siblings)	0.6	0.7	0.9	-1.0	0.7
Alzheimer’s Disease (in mother)	0.5	0.5	0.7	-0.6	0.8
Prostate Cancer	0.5	0.7	1.1	-1.1	-0.6
Allergy or Eczema	0.5	1.3	2.1	0.7	-1.5
Respiratory disease	0.5	1.1	1.7	-0.7	-1.3
Hearing difficulty/problems with background noise	0.5	0.9	1.4	0.6	1.2
Had menopause	0.5	0.6	0.8	0.9	-0.7
Fluid intelligence score	0.5	1.0	1.1	-1.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	1.1	0.0
Prospective memory result	0.5	0.6	0.6	0.7	0.8
Number of full brothers	0.5	0.7	1.3	0.1	1.1
Pulse wave peak to peak time	0.5	0.6	1.2	1.1	-0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	1.0	0.4
Asthma (self-reported)	0.5	1.0	1.9	-0.4	-1.4
Medication: Aspirin	0.5	0.7	0.7	-0.9	-0.8
High cholesterol (Self-reported)	0.5	0.9	1.8	-1.3	-0.2
Ever depressed for a whole week	0.5	0.6	1.1	1.1	-0.1
Cholesterol lowering medication	0.5	0.8	1.3	-0.5	1.1
Alcohol drinker status: Previous	0.5	0.5	0.6	0.7	0.8
Schizophrenia vs Biploar Disorder	0.4	0.6	0.9	1.0	0.5
Ulcerative Colitis (UC)	0.4	0.8	1.5	-1.2	-0.2
LDL Cholesterol	0.4	0.6	1.1	-0.3	1.1
Primary Biliary Cirrhosis	0.4	0.5	1.0	0.1	-1.0
Ever had hysterectomy (womb removed)	0.4	0.5	0.6	-0.5	0.8
Angina	0.4	0.6	1.0	-0.4	1.0
Pack years adult smoking proportion	0.4	0.6	1.1	0.4	1.1
Taking other prescription medications	0.4	0.6	1.0	0.4	1.0
Waist circumference	0.4	1.5	3.0	1.7	-0.1
Had other major operations	0.4	0.5	1.0	1.0	-0.1
Diabetes (self-reported)	0.4	0.6	0.9	-0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.2	-1.0
Noisy workplace	0.4	0.5	0.9	0.1	1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.0	1.0	-0.8
Asthma	0.4	0.9	1.6	-0.4	-1.2
Medication: Cholesterol lowering	0.4	0.6	1.1	-1.1	0.2
Length of working week for main job	0.4	0.4	0.8	0.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	1.2	-0.3
Overall health rating	0.4	0.8	1.5	1.2	-0.4
Age at last live birth	0.4	0.5	1.0	0.3	-1.0
Loneliness, isolation	0.4	0.5	0.7	0.8	0.6
Eye problems/disorders: Cataract	0.4	0.4	0.6	-0.5	-0.8
Pack years of smoking	0.4	0.6	1.0	0.3	1.0
Impedance of whole body	0.4	1.9	3.7	0.4	-1.9
Neuroticism (Nagel 2018)	0.3	0.8	1.4	0.5	1.2
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.4	0.8
Crohns Disease (2017)	0.3	0.8	1.5	0.1	1.2
Irritable Bowel Disease (IBD)	0.3	0.7	0.8	-0.9	0.8
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	0.1
Mean Putamen Volume	0.3	0.4	0.6	-0.8	-0.4
Lupus	0.3	0.5	0.9	0.3	-0.9
Systolic Blood Pressure	0.3	1.5	2.9	-0.1	-1.7
Hair Pigment	0.3	8.0	9.7	2.5	-3.1
Vitamin and mineral supplements	0.3	0.3	0.5	0.7	0.5
Diabetes (father)	0.3	0.4	0.7	-0.9	-0.2
Current tobacco smoking	0.3	0.5	0.9	-0.3	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.2	-1.0
Trunk fat mass	0.3	1.4	2.8	1.7	-0.3
Medication: Lansoprazole	0.3	0.4	0.8	0.0	0.9
Loud music exposure frequency	0.3	0.4	0.7	-0.8	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.9	-0.2
Body fat percentage	0.3	1.1	2.0	-0.3	1.4
Qualifications: College or University degree	0.3	0.8	1.2	0.7	-1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.5	-0.5	0.7
Medication for pain relief, constipation, heartburn	0.3	0.6	0.8	0.6	0.9
Whole body fat mass	0.3	1.1	2.0	1.4	0.4
Breast cancer (self-reported)	0.3	0.3	0.3	0.5	-0.6
Medication: Paracetamol	0.3	0.4	0.6	0.8	-0.5
Leg fat percentage (left)	0.3	1.3	1.8	-0.8	1.4
Average weekly beer plus cider intake	0.3	0.4	0.8	0.9	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.7	-0.3
Commuting to job workplace: Cycle	0.3	0.4	0.4	-0.6	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	-1.1	0.4
Crohns Disease (2012)	0.2	0.3	0.5	0.4	0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.8	-0.2
Lung FEV1/FVC ratio	0.2	0.9	1.7	0.2	-1.3
Chronotype (morning person)	0.2	0.4	0.8	-0.9	-0.2
Average weekly spirits intake	0.2	0.3	0.5	0.0	-0.7
Sensitivity / hurt feelings	0.2	0.4	0.5	0.7	-0.5
Diabetes (mother)	0.2	0.2	0.4	0.6	0.2
Medication: Atenolol	0.2	0.2	0.4	-0.6	-0.2
Mouth/teeth dental problems	0.2	0.3	0.3	-0.6	-0.4
Impedance of arm (right)	0.2	0.8	1.5	-0.4	-1.2
Hip circumference	0.2	1.0	1.5	0.7	1.2
Time employed in main current job	0.2	0.2	0.2	-0.5	0.4
Father’s age at death	0.2	0.3	0.3	-0.5	-0.5
Falls in the last year	0.2	0.2	0.4	-0.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.3	-0.6
Depression (self-reported)	0.2	0.3	0.5	0.2	-0.7
Impedance of arm (left)	0.2	1.0	2.0	-0.1	-1.4
Exposure to tobacco smoke at home	0.2	0.3	0.3	-0.5	0.6
Peak expiratory flow (PEF)	0.2	0.4	0.6	0.8	-0.5
Medication: Paracetamol	0.2	0.3	0.6	0.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.8	-0.3	0.9
Leg fat percentage (right)	0.2	0.9	1.6	-0.4	1.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	0.7	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.7	0.1
Leg fat mass (right)	0.2	0.8	1.3	1.1	0.4
Suffer from ‘nerves’	0.2	0.3	0.5	0.1	0.7
Average weekly red wine intake	0.2	0.3	0.5	-0.7	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.7	0.3
Back pain experienced in last month	0.2	0.2	0.5	0.7	0.2
Smoking status: Current	0.2	0.3	0.5	-0.2	0.7
Arm fat mass (left)	0.2	0.6	0.9	0.6	0.9
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.7	-0.2
Illnesses of father: High blood pressure	0.2	0.2	0.3	-0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.5	0.8	0.5	-0.9
Ovarian Cancer	0.1	0.1	0.2	0.5	0.1
Age at First Birth	0.1	0.2	0.4	-0.3	0.6
Triglycerides	0.1	0.2	0.3	-0.0	0.6
Ulcerative Colitis	0.1	0.2	0.3	-0.3	0.5
Blood Platelet Count	0.1	1.3	2.1	1.4	-0.7
Tanning	0.1	1.0	2.0	0.0	1.4
Systolic blood pressure, automated reading	0.1	0.2	0.2	0.3	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.2	-0.3
Supplements: Zinc	0.1	0.1	0.1	-0.4	-0.4
Trunk fat percentage	0.1	0.6	1.1	-0.2	1.0
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.1	-0.4
Alcohol usually taken with meals	0.1	0.2	0.3	-0.5	-0.1
Qualifications: None of the above	0.1	0.1	0.2	0.4	-0.3
Heart attack	0.1	0.1	0.3	-0.1	-0.5
Allergy	0.1	0.3	0.5	0.1	0.7
Happiness	0.1	0.1	0.1	0.2	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.0	-0.4
Arm fat mass (right)	0.1	0.6	1.0	0.4	1.0
Pulse wave reflection index	0.1	0.1	0.1	-0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	-0.4	-0.3
Glaucoma (self-reported)	0.1	0.1	0.1	0.4	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	0.1
Angina (self-reported)	0.1	0.1	0.2	-0.2	0.4
Supplements: Vitamin C	0.1	0.1	0.2	0.2	0.5
Hypertension (Self-reported)	0.1	0.2	0.4	0.6	-0.1
Illnesses of father: Heart disease	0.1	0.1	0.1	0.4	0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.0	0.4
Ever had bowel cancer screening	0.1	0.1	0.1	0.3	-0.2
Medication for cholesterol	0.1	0.2	0.3	-0.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.3	0.4
Medication: Atorvastatin	0.1	0.1	0.2	0.2	0.5
Irritability	0.1	0.2	0.4	-0.6	0.0
Risk taking	0.1	0.2	0.2	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.1	-0.6
Leg fat mass (left)	0.1	0.6	0.9	0.9	0.5
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.3	-0.0
Cardiovascular Disease	0.0	0.2	0.3	-0.5	0.2
Hypothyroidism (self reported)	0.0	0.1	0.1	0.1	0.3
Neuroticism	0.0	0.0	0.0	0.0	0.2
Number of treatments/medications taken	0.0	0.0	0.0	-0.1	0.1
Maternal smoking around birth	0.0	0.0	0.0	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.3	0.1
High blood pressure	0.0	0.0	0.0	0.0	0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.1	-0.3
Financial difficulties in last 2 years	0.0	0.1	0.1	0.2	0.3
Neuroticism score	0.0	0.1	0.1	-0.2	0.3
Number of live births	0.0	0.0	0.1	0.1	-0.3
Age at first live birth	0.0	0.0	0.0	-0.0	-0.1
Medication: Blood pressure	0.0	0.0	0.0	0.1	0.2
Medication: Ibuprofen	0.0	0.0	0.1	0.2	0.3
Medication: Omeprazole	0.0	0.0	0.0	0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.2	-0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.1	0.1
Mother’s age at death	0.0	0.1	0.1	-0.3	-0.1
Medication: Blood pressure	0.0	0.1	0.2	-0.0	-0.4
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.0	-0.5
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	0.0	0.3

Hub : Genes

PTMA

Models

Trait associations